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152. Figure S2 from Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

Author

Iorgulescu, J. Bryan, primary, Gokhale, Prafulla C., primary, Speranza, Maria C., primary, Eschle, Benjamin K., primary, Poitras, Michael J., primary, Wilkens, Margaret K., primary, Soroko, Kara M., primary, Chhoeu, Chhayheng, primary, Knott, Aine, primary, Gao, Yan, primary, Lim-Fat, Mary Jane, primary, Baker, Gregory J., primary, Bonal, Dennis M., primary, Nguyen, Quang-Dé, primary, Grant, Gareth R. L., primary, Ligon, Keith L., primary, Sorger, Peter K., primary, Chiocca, E. Antonio, primary, Anderson, Ana C., primary, Kirschmeier, Paul T., primary, Sharpe, Arlene H., primary, Freeman, Gordon J., primary, and Reardon, David A., primary

Published
2023
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153. Supplementary Data from Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma

Author

Denize, Thomas, primary, Hou, Yue, primary, Pignon, Jean-Christophe, primary, Walton, Emily, primary, West, Destiny J., primary, Freeman, Gordon J., primary, Braun, David A., primary, Wu, Catherine J., primary, Gupta, Saurabh, primary, Motzer, Robert J., primary, Atkins, Michael B., primary, McDermott, David, primary, Choueiri, Toni K., primary, Shukla, Sachet A., primary, and Signoretti, Sabina, primary

Published
2023
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154. Supplementary Figure Legend from PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies

Author

Chen, Benjamin J., primary, Chapuy, Bjoern, primary, Ouyang, Jing, primary, Sun, Heather H., primary, Roemer, Margaretha G.M., primary, Xu, Mina L., primary, Yu, Hongbo, primary, Fletcher, Christopher D.M., primary, Freeman, Gordon J., primary, Shipp, Margaret A., primary, and Rodig, Scott J., primary

Published
2023
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155. Supplementary Figure 4 from PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

Author

Flaifel, Abdallah, primary, Xie, Wanling, primary, Braun, David A., primary, Ficial, Miriam, primary, Bakouny, Ziad, primary, Nassar, Amin H., primary, Jennings, Rebecca B., primary, Escudier, Bernard, primary, George, Daniel J., primary, Motzer, Robert J., primary, Morris, Michael J., primary, Powles, Thomas, primary, Wang, Evelyn, primary, Huang, Ying, primary, Freeman, Gordon J., primary, Choueiri, Toni K., primary, and Signoretti, Sabina, primary

Published
2023
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156. Table S1 from Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

Author

Iorgulescu, J. Bryan, primary, Gokhale, Prafulla C., primary, Speranza, Maria C., primary, Eschle, Benjamin K., primary, Poitras, Michael J., primary, Wilkens, Margaret K., primary, Soroko, Kara M., primary, Chhoeu, Chhayheng, primary, Knott, Aine, primary, Gao, Yan, primary, Lim-Fat, Mary Jane, primary, Baker, Gregory J., primary, Bonal, Dennis M., primary, Nguyen, Quang-Dé, primary, Grant, Gareth R. L., primary, Ligon, Keith L., primary, Sorger, Peter K., primary, Chiocca, E. Antonio, primary, Anderson, Ana C., primary, Kirschmeier, Paul T., primary, Sharpe, Arlene H., primary, Freeman, Gordon J., primary, and Reardon, David A., primary

Published
2023
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157. Figure S1 from Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

Author

Giraldo, Nicolas A., primary, Becht, Etienne, primary, Pagès, Franck, primary, Skliris, Georgios, primary, Verkarre, Virginie, primary, Vano, Yann, primary, Mejean, Arnaud, primary, Saint-Aubert, Nicolas, primary, Lacroix, Laetitia, primary, Natario, Ivo, primary, Lupo, Audrey, primary, Alifano, Marco, primary, Damotte, Diane, primary, Cazes, Aurelie, primary, Triebel, Frederic, primary, Freeman, Gordon J., primary, Dieu-Nosjean, Marie-Caroline, primary, Oudard, Stephane, primary, Fridman, Wolf H., primary, and Sautès-Fridman, Catherine, primary

Published
2023
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158. Supplementary Table from PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

Author

Flaifel, Abdallah, primary, Xie, Wanling, primary, Braun, David A., primary, Ficial, Miriam, primary, Bakouny, Ziad, primary, Nassar, Amin H., primary, Jennings, Rebecca B., primary, Escudier, Bernard, primary, George, Daniel J., primary, Motzer, Robert J., primary, Morris, Michael J., primary, Powles, Thomas, primary, Wang, Evelyn, primary, Huang, Ying, primary, Freeman, Gordon J., primary, Choueiri, Toni K., primary, and Signoretti, Sabina, primary

Published
2023
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160. Supplementary Figure 2 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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161. Supplementary Data from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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162. Supplementary Figure 1 from PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

Author

Flaifel, Abdallah, primary, Xie, Wanling, primary, Braun, David A., primary, Ficial, Miriam, primary, Bakouny, Ziad, primary, Nassar, Amin H., primary, Jennings, Rebecca B., primary, Escudier, Bernard, primary, George, Daniel J., primary, Motzer, Robert J., primary, Morris, Michael J., primary, Powles, Thomas, primary, Wang, Evelyn, primary, Huang, Ying, primary, Freeman, Gordon J., primary, Choueiri, Toni K., primary, and Signoretti, Sabina, primary

Published
2023
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163. Supplementary Figure 2 from PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

Author

Flaifel, Abdallah, primary, Xie, Wanling, primary, Braun, David A., primary, Ficial, Miriam, primary, Bakouny, Ziad, primary, Nassar, Amin H., primary, Jennings, Rebecca B., primary, Escudier, Bernard, primary, George, Daniel J., primary, Motzer, Robert J., primary, Morris, Michael J., primary, Powles, Thomas, primary, Wang, Evelyn, primary, Huang, Ying, primary, Freeman, Gordon J., primary, Choueiri, Toni K., primary, and Signoretti, Sabina, primary

Published
2023
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164. Supplementary Figures 1 - 2 from PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies

Author

Chen, Benjamin J., primary, Chapuy, Bjoern, primary, Ouyang, Jing, primary, Sun, Heather H., primary, Roemer, Margaretha G.M., primary, Xu, Mina L., primary, Yu, Hongbo, primary, Fletcher, Christopher D.M., primary, Freeman, Gordon J., primary, Shipp, Margaret A., primary, and Rodig, Scott J., primary

Published
2023
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165. Supplementary Figure S1 from PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer

Author

Kansy, Benjamin A., primary, Concha-Benavente, Fernando, primary, Srivastava, Raghvendra M., primary, Jie, Hyun-Bae, primary, Shayan, Gulidanna, primary, Lei, Yu, primary, Moskovitz, Jessica, primary, Moy, Jennifer, primary, Li, Jing, primary, Brandau, Sven, primary, Lang, Stephan, primary, Schmitt, Nicole C., primary, Freeman, Gordon J., primary, Gooding, William E., primary, Clump, David A., primary, and Ferris, Robert L., primary

Published
2023
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166. Supplementary Methods and Legends from Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

Author

Iorgulescu, J. Bryan, primary, Gokhale, Prafulla C., primary, Speranza, Maria C., primary, Eschle, Benjamin K., primary, Poitras, Michael J., primary, Wilkens, Margaret K., primary, Soroko, Kara M., primary, Chhoeu, Chhayheng, primary, Knott, Aine, primary, Gao, Yan, primary, Lim-Fat, Mary Jane, primary, Baker, Gregory J., primary, Bonal, Dennis M., primary, Nguyen, Quang-Dé, primary, Grant, Gareth R. L., primary, Ligon, Keith L., primary, Sorger, Peter K., primary, Chiocca, E. Antonio, primary, Anderson, Ana C., primary, Kirschmeier, Paul T., primary, Sharpe, Arlene H., primary, Freeman, Gordon J., primary, and Reardon, David A., primary

Published
2023
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167. Supplementary Figure 1 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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168. Supplementary Figure 3 from PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

Author

Flaifel, Abdallah, primary, Xie, Wanling, primary, Braun, David A., primary, Ficial, Miriam, primary, Bakouny, Ziad, primary, Nassar, Amin H., primary, Jennings, Rebecca B., primary, Escudier, Bernard, primary, George, Daniel J., primary, Motzer, Robert J., primary, Morris, Michael J., primary, Powles, Thomas, primary, Wang, Evelyn, primary, Huang, Ying, primary, Freeman, Gordon J., primary, Choueiri, Toni K., primary, and Signoretti, Sabina, primary

Published
2023
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170. Supplementary Figure 3 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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171. Supplementary methods from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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176. Supplementary method figure from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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178. Supplemental Figures from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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182. Supplementary figure legends from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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184. Data from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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197. Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

Author

Datta, Meenal, primary, Chatterjee, Sampurna, additional, Perez, Elizabeth M., additional, Gritsch, Simon, additional, Roberge, Sylvie, additional, Duquette, Mark, additional, Chen, Ivy X., additional, Naxerova, Kamila, additional, Kumar, Ashwin S., additional, Ghosh, Mitrajit, additional, Emblem, Kyrre E., additional, Ng, Mei R., additional, Ho, William W., additional, Kumar, Pragya, additional, Krishnan, Shanmugarajan, additional, Dong, Xinyue, additional, Speranza, Maria C., additional, Neagu, Martha R., additional, Iorgulescu, J. Bryan, additional, Huang, Raymond Y., additional, Youssef, Gilbert, additional, Reardon, David A., additional, Sharpe, Arlene H., additional, Freeman, Gordon J., additional, Suvà, Mario L., additional, Xu, Lei, additional, and Jain, Rakesh K., additional

Published
2023
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199. ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Author

Xiao, Xiangling, Shi, Jie, He, Chuan, Bu, Xia, Sun, Yishuang, Gao, Minling, Xiang, Bolin, Xiong, Wenjun, Dai, Panpan, Mao, Qi, Xing, Xixin, Yao, Yingmeng, Yu, Haisheng, Xu, Gaoshan, Li, Siqi, Ren, Yan, Chen, Baoxiang, Jiang, Congqing, Meng, Geng, Lee, Yu Ru, Wei, Wenyi, Freeman, Gordon J., Xie, Conghua, Zhang, Jinfang, Xiao, Xiangling, Shi, Jie, He, Chuan, Bu, Xia, Sun, Yishuang, Gao, Minling, Xiang, Bolin, Xiong, Wenjun, Dai, Panpan, Mao, Qi, Xing, Xixin, Yao, Yingmeng, Yu, Haisheng, Xu, Gaoshan, Li, Siqi, Ren, Yan, Chen, Baoxiang, Jiang, Congqing, Meng, Geng, Lee, Yu Ru, Wei, Wenyi, Freeman, Gordon J., Xie, Conghua, and Zhang, Jinfang

Abstract

The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases regulating PD-1 stability have been reported, deubiquitinases governing PD-1 homeostasis to modulate tumor immunotherapy remain unknown. Here, we identify the ubiquitin-specific protease 5 (USP5) as a bona fide deubiquitinase for PD-1. Mechanistically, USP5 interacts with PD-1, leading to deubiquitination and stabilization of PD-1. Moreover, extracellular signal-regulated kinase (ERK) phosphorylates PD-1 at Thr234 and promotes PD-1 interaction with USP5. Conditional knockout of Usp5 in T cells increases the production of effector cytokines and retards tumor growth in mice. USP5 inhibition in combination with Trametinib or anti-CTLA-4 has an additive effect on suppressing tumor growth in mice. Together, this study describes a molecular mechanism of ERK/USP5-mediated regulation of PD-1 and identifies potential combinatorial therapeutic strategies for enhancing anti-tumor efficacy., The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases regulating PD-1 stability have been reported, deubiquitinases governing PD-1 homeostasis to modulate tumor immunotherapy remain unknown. Here, we identify the ubiquitin-specific protease 5 (USP5) as a bona fide deubiquitinase for PD-1. Mechanistically, USP5 interacts with PD-1, leading to deubiquitination and stabilization of PD-1. Moreover, extracellular signal-regulated kinase (ERK) phosphorylates PD-1 at Thr234 and promotes PD-1 interaction with USP5. Conditional knockout of Usp5 in T cells increases the production of effector cytokines and retards tumor growth in mice. USP5 inhibition in combination with Trametinib or anti-CTLA-4 has an additive effect on suppressing tumor growth in mice. Together, this study describes a molecular mechanism of ERK/USP5-mediated regulation of PD-1 and identifies potential combinatorial therapeutic strategies for enhancing anti-tumor efficacy.

Published
2023

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