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151. Patient‐centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA‐EAACI approach

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the centre of the health system and is likely to optimise the practice of allergy. ARIA (Allergic Rhinitis and its Impact on Asthma) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomised controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, were embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023
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152. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air (R) longitudinal study

Author: Sousa-Pinto, Bernardo, Schunemann, Holger J., Sa-Sousa, Ana, Vieira, Rafael Jose, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mosges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, Sousa-Pinto, Bernardo, Schunemann, Holger J., Sa-Sousa, Ana, Vieira, Rafael Jose, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mosges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., and Bousquet, Jean
Abstract: Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air (R), these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air (R) longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air (R) data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age +/- SD = 39.1 +/- 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms. [GRAPHICS] .
Published: 2023

153. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach

Author: Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., Zuberbier, Torsten, Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., and Zuberbier, Torsten
Abstract: MASK‐air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK‐air® is a Good Practice of DG Santé on digitally‐enabled, patient‐centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co‐operation and Development). MASK‐air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK‐air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as‐needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom‐medication score (ARIA‐EAACI‐CSMS) has been validated for clinical practice and trials. The implications of the novel MASK‐air® results should lead to change management in rhinitis and asthma.
Published: 2023

154. Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies

Author: Simões Cunha, Mafalda, primary, Amaral, Rita, additional, Pereira, Ana Margarida, additional, Almeida, Rute, additional, Alves-Correia, Magna, additional, Loureiro, Cláudia Chaves, additional, Lopes, Cristina, additional, Carvalho, Joana, additional, Ribeiro, Carmelita, additional, Vidal, Carmen, additional, Antolín-Amérigo, Dario, additional, Pinto, Diana, additional, Ferreira-Magalhães, Manuel, additional, Vasconcelos, Maria João, additional, Lozoya, Carlos, additional, Santos, Natacha, additional, Cardia, Francisca, additional, Taborda-Barata, Luís, additional, Ferreira, Rosário, additional, Morais Silva, Pedro, additional, Ferreira, Tania Monteiro, additional, Câmara, Raquel, additional, Silva, Eurico, additional, Bordalo, Diana, additional, Guimarães, Cristina, additional, Calix, Maria José, additional, da Silva, Sofia, additional, Marques, Maria Luís, additional, Morete, Ana, additional, Nunes, Carlos, additional, Vieira, Cláudia, additional, Páscoa, Rosália, additional, Alves, Adelaide, additional, Marques, José Varanda, additional, Reis, Bruno, additional, Monteiro, Luís, additional, Monteiro, Rosário, additional, Cepa, Margarida, additional, Valentim, Bruno, additional, Coelho, Daniela Sousa, additional, Fernandes, Sara, additional, Meireles, Patrícia, additional, Aguiar, Margarida Abreu, additional, Mourão, Ana Rita, additional, Fonseca, Joao A, additional, and Jácome, Cristina, additional
Published: 2023
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155. Improvement of daily allergy control by sublingual immunotherapy: A MASK ‐air® study

Author: Bousquet, Jean, primary, Sousa‐Pinto, Bernardo, additional, Shamji, Mohamed H., additional, Anto, Josep M., additional, Klimek, Ludger, additional, Canonica, G. Walter, additional, Czarlewski, Wienczyslawa, additional, Devillier, Philippe, additional, Haahtela, Tari, additional, Laune, Daniel, additional, Mullol, Joaquim, additional, Brussino, Luisa, additional, Cecchi, Lorenzo, additional, Kvedariene, Violeta, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Samolinski, Boleslaw, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Valiulis, Arunas, additional, Ventura, Maria Teresa, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Valovirta, Erkka, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Pfaar, Oliver, additional
Published: 2023
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156. An experimental study of the polycrystalline plasticity of austenitic stainless steel

Author: Di Gioacchino, Fabio and Quinta da Fonseca, João
Published: 2015
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157. The Eastern Lower Tagus Valley Fault Zone in central Portugal: Active faulting in a low-deformation region within a major river environment

Author: Canora, Carolina, Vilanova, Susana P., Besana-Ostman, Glenda M., Carvalho, João, Heleno, Sandra, and Fonseca, Joao
Published: 2015
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158. Regional and seasonal characteristics of global horizontal irradiance forecasts obtained from the Japan Meteorological Agency mesoscale model

Author: Ohtake, Hideaki, da Silva Fonseca, Joao Gari, Jr., Takashima, Takumi, Oozeki, Takashi, Shimose, Ken-ichi, and Yamada, Yoshinori
Published: 2015
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159. Cooperative home energy management using batteries for a photovoltaic system considering the diversity of households

Author: Iwafune, Yumiko, Ikegami, Takashi, Fonseca, Joao Gari da Silva, Jr., Oozeki, Takashi, and Ogimoto, Kazuhiko
Published: 2015
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160. Anti-type II collagen antibodies detection and avidity in patients with oligoarticular and polyarticular forms of juvenile idiopathic arthritis

Author: Araujo, Galber R., Fonseca, João E., Fujimura, Patricia T., Cunha-Junior, Jair P., Silva, Carlos H.M., Mourão, Ana F., Canhão, Helena, Goulart, Luiz R., Gonçalves, João, and Ueira-Vieira, Carlos
Published: 2015
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161. Effect of Aging and Cardiovascular Risk Factors on Receptor Tie1 Expression in Human Erectile Tissue

Author: Fonseca, João, Tomada, Nuno, Magalhães, Alexandre, Rodrigues, Adriana R., Gouveia, Alexandra M., and Neves, Delminda
Published: 2015
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162. Global comment on the use of hydroxychloroquine during the periconception period and pregnancy in women with autoimmune diseases

Author: Schreiber, Karen, Giles, Ian, Costedoat-Chalumeau, Nathalie, Nelson-Piercy, Catherine, Dolhain, Radboud JEM, Mosca, Marta, Förger, Frauke, Fischer-Betz, Rebecca, Molto, Anna, Tincani, Angela, Pasquier, Elisabeth, Marin, Benoit, Elefant, Elisabeth, Salmon, Jane, Bermas, Bonnie L, Sammaritano, Lisa, Clowse, Megan E B, Chambers, Christina, Buyon, Jill, Inoue, Saori Abe, Agmon-Levin, Nancy, Aguilera, Silvia, Emadi, Samar Al, Andersen, Jeanette, Andrade, Danieli, Antovic, Aleksandra, Arnaud, Laurent, Christiansen, Alice Ashouri, Avcin, Tadej, Badreh-Wirström, Sara, Bertsias, George, Bini, Ilaria, Bobirca, Anca, Branch, Ware, Brucato, Antonio, Bultink, Irene, Capela, Susanna, Cecchi, Irene, Cervera, Ricard, Chighizola, Cecilia, Cobilinschi, Claudia, Cuadrado, Maria Jose, Dey, Dzifa, Etomi, Oseme, Espinosa, Gerard, Flint, Julia, Fonseca, João-Eurico, Fritsch-Stork, Ruth, Gerosa, Maria, Glintborg, Bente, Skorpen, Carina Gøtestam, Goulden, Bethan, Graversgaard, Christine, Gunnarsson, Iva, Gupta, Latika, Hetland, Merete, Hodson, Ken, Hunt, Beverley J, Isenberg, David, Jacobsen, Søren, Khamashta, Munther, Levy, Roger, Linde, Louise, Lykke, Jacob, Meissner, Yvette, Moore, Louise, Morand, Eric, Navarra, Sandra, Opris-Belinski, Daniela, Østensen, Monika, Ozawa, Hiroki, Perez-Garcia, Luis Fernando, Petri, Michelle, Pons-Estel, Guillermo J, Radin, Massimo, Raio, Luigi, Rottenstreich, Amihai, Ruiz-Irastorza, Guillermo, Tunjić, Slađana Rumpl, Rygg, Marite, Sciascia, Savino, Strangfeld, Anja, Svenungsson, Elisabet, Tektonidou, Maria, Troldborg, Anne, Vinet, Evelyne, Vojinovic, Jelena, Voss, Anne, Wallenius, Marianne, and Andreoli, Laura
Published: 2023
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163. Consistent trajectories of rhinitis control and treatment in 16,177 weeks

Author: Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Subjects: rhinitis, real-world data, patient-reported outcomes, Immunology, Immunology and Allergy, mobile health
Abstract: Funding Information: MASK‐air® has been supported by EU grants (POLLAR, EIT Health; Structural and Development Funds, Twinning, EIP on AHA and H2020) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis and Uriach. Publisher Copyright: © 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms. publishersversion published
Published: 2023

164. Comment on Omira, Baptista and Matias (2015), “Probabilistic Tsunami Hazard in the Northeast Atlantic from Near- and Far-Field Tectonic Sources”

Author: Fonseca, Joao F. B. D.
Published: 2017
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165. Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum

Author: Freitas, Margarida, Rodrigues, Adriana R., Tomada, Nuno, Fonseca, João, Magalhães, Alexandre, Gouveia, Alexandra M., and Neves, Delminda
Published: 2015
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166. Pulmonary aspiration thrombectomy with Lightning Flash catheter in a young patient with fibrosing mediastinitis

Author: Peclat, Lucas, Fonseca, João Marcos Fonseca e, Barreto, Fernando Tebet Ramos, Peclat, Rafael, Peclat, Ana Paula Rolim Maia, and Peclat, Julio
Published: 2025
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167. Training Clinical Decision-Making through Simulation

Author: Flores, Cecilia Dias, Bez, Marta Rosecler, Respício, Ana, Fonseca, João Marcelo, van der Aalst, Wil, editor, Mylopoulos, John, editor, Rosemann, Michael, editor, Shaw, Michael J., editor, Szyperski, Clemens, editor, Hernández, Jorge E., editor, Zarate, Pascale, editor, Dargam, Fátima, editor, Delibašić, Boris, editor, Liu, Shaofeng, editor, and Ribeiro, Rita, editor
Published: 2012
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168. Influence Diagram for Selection of Pedagogical Strategies in a Multi-Agent System Learning

Author: Bez, Marta R., Flores, Cecília D., Fonseca, João M. L., Maroni, Vinicius, Barros, Paulo R., Vicari, Rosa M., Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Nierstrasz, Oscar, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Sudan, Madhu, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Vardi, Moshe Y., Editorial Board Member, Weikum, Gerhard, Editorial Board Member, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Pavón, Juan, editor, Duque-Méndez, Néstor D., editor, and Fuentes-Fernández, Rubén, editor
Published: 2012
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169. The ARIA-MASK-air® approach

Author: Bousquet, Jean, Anto, Josep M., Sousa-Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves-Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev-Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro-Martins, Pedro, Charpin, Denis, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu-Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romantowski, Jan, Sá-Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., Zuberbier, Torsten, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Comprehensive Health Research Centre (CHRC) - pólo NMS
Subjects: Pulmonary and Respiratory Medicine, rhinitis, mHealth, digital, Immunology, Immunology and Allergy, asthma, MASK-air
Abstract: Funding Information: The authors thank Ms Véronique Pretschner for submitting the paper. MASK‐air has been supported by Charité Universitätsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis, Stallergènes‐Greer and Uriach. None for the study. ® Publisher Copyright: © 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. MASK-air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma. publishersversion published
Published: 2023

170. Measuring adherence to inhaled control medication in patients with asthma : Comparison among an asthma app, patient self-report and physician assessment

Author: Cachim, Afonso, Pereira, Ana Margarida, Almeida, Rute, Amaral, Rita, Correia, Magna Alves, Marques, Pedro Vieira, Loureiro, Cláudia Chaves, Ribeiro, Carmelita, Cardia, Francisca, Gomes, Joana, Vidal, Carmen, Silva, Eurico, Rocha, Sara, Rocha, Diana, Marques, Maria Luís, Páscoa, Rosália, Morais, Daniela, Cruz, Ana Margarida, Santalha, Marta, Simões, José Augusto Rodrigues, Silva, Sofia da, Silva, Diana, Gerardo, Rita, Bom, Filipa Todo, Morete, Ana, Vieira, Inês, Vieira, Pedro, Monteiro, Rosário, Raimundo, Rosário, Monteiro, Luís, Neves, Ângela, Santos, Carlos, Penas, Ana Margarida, Regadas, Rita, Marques, José Varanda, Rosendo, Inês, Aguiar, Margarida Abreu, Fernandes, Sara, Cardoso, Carlos Seiça, Pimenta, F., Meireles, Patrícia, Gonçalves, Mariana, Fonseca, Joao A, Jácome, Cristina, and uBibliorum
Subjects: Pulmonary and Respiratory Medicine, mobile apps, self-management, Respiratory Medicine and Allergy, Clinical decision support systems, Immunology, Technology assessment, asthma, technology assessment, smartphone, Asthma, mHealth, Mobile apps, medication adherence, Self-management, Immunology and Allergy, eHealth, Patient participation, Smartphone, patient participation, Medication adherence, clinical decision support systems, Lungmedicin och allergi
Abstract: Background Previous studies have demonstrated the feasibility of using an asthma app to support medication management and adherence but failed to compare with other measures currently used in clinical practice. However, in a clinical setting, any additional adherence measurement must be evaluated in the context of both the patient and physician perspectives so that it can also help improve the process of shared decision making. Thus, we aimed to compare different measures of adherence to asthma control inhalers in clinical practice, namely through an app, patient self-report and physician assessment. Methods This study is a secondary analysis of three prospective multicentre observational studies with patients (≥13 years old) with persistent asthma recruited from 61 primary and secondary care centres in Portugal. Patients were invited to use the InspirerMundi app and register their inhaled medication. Adherence was measured by the app as the number of doses taken divided by the number of doses scheduled each day and two time points were considered for analysis: 1-week and 1-month. At baseline, patients and physicians independently assessed adherence to asthma control inhalers during the previous week using a Visual Analogue Scale (VAS 0–100). Results A total of 193 patients (72% female; median [P25–P75] age 28 [19–41] years old) were included in the analysis. Adherence measured by the app was lower (1 week: 31 [0–71]%; 1 month: 18 [0–48]%) than patient self-report (80 [60–95]) and physician assessment (82 [51–94]) (p 0.05). There was a moderate correlation between patient self-report and physician assessment (ρ = 0.596, p
Published: 2023

171. Improving Active Learning Performance through the Use of Data Augmentation

Author: Fonseca, Joao, primary and Bacao, Fernando, additional
Published: 2023
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172. A novel integrated framework for reproducible formability predictions using virtual materials testing

Author: Plowman, Adam, primary, Jedrasiak, Patryk, additional, Jailin, Thomas, additional, Crowther, Peter, additional, Mishra, Sumeet, additional, Shanthraj, Pratheek, additional, and Quinta da Fonseca, Joao, additional
Published: 2023
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173. On Acquiring Accurate Micro-Scale Indentation Displacement Fields Via an Optical Flow Algorithm

Author: Han, Giyeol, primary, Lee, Bohyeon, additional, Fonseca, Joao Henrique, additional, and Lee, Hyungyil, additional
Published: 2023
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174. MASK‐air ® real‐world data in respiratory allergy in old‐age adults

Author: Taborda‐Barata, Luis, primary, Ventura, Maria Teresa, additional, Blain, Hubert, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linneman, Désirée E., additional, Pham‐Thi, Nhân, additional, Samolinski, Boleslaw, additional, Fonseca, Joao A., additional, Bousquet, Jean, additional, and Sousa‐Pinto, Bernardo, additional
Published: 2023
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175. Accident-Induced Absence from Work and Wage Ladders

Author: Biro, Aniko, primary, Bisztray, Márta, additional, Galindo da Fonseca, Joao, additional, and Molnar, Timea Laura, additional
Published: 2023
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176. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach

Author: Bousquet, Jean, primary, Anto, Josep M., additional, Sousa‐Pinto, Bernardo, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Haahtela, Tari, additional, Klimek, Ludger, additional, Pfaar, Oliver, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Arnavielhe, Sylvie, additional, Basagaña, Xavier, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chaves‐Loureiro, Claudia, additional, Costa, Elisio, additional, Cruz, Alvaro A., additional, Gemicioglu, Bilun, additional, Fokkens, Wytske J., additional, Ivancevich, Juan Carlos, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Rouadi, Philip W., additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sofiev, Mikhail, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Vieira, Rafael José, additional, Zidarn, Mihaela, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bédard, Annabelle, additional, Benveniste, Samuel, additional, Bewick, Michael, additional, Bindslev‐Jensen, Carsten, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Bourret, Rodolphe, additional, Braido, Fulvio, additional, Carreiro‐Martins, Pedro, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Del Giacco, Stefano, additional, de Blay, Frédéric, additional, Devillier, Philippe, additional, De Vries, Govert, additional, Doulaptsi, Maria, additional, Doyen, Virginie, additional, Dray, Gérard, additional, Fontaine, Jean‐François, additional, Gomez, R. Maximiliano, additional, Hagemann, Jan, additional, Heffler, Enrico, additional, Hofmann, Maja, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, Kritikos, Vicky, additional, Kull, Inger, additional, Kulus, Marek, additional, Lourenço, Olga, additional, Mathieu‐Dupas, Eve, additional, Menditto, Enrica, additional, Mösges, Ralph, additional, Murray, Ruth, additional, Nadif, Rachel, additional, Neffen, Hugo, additional, Nicola, Stefania, additional, O’Hehir, Robyn, additional, Olze, Heidi, additional, Palamarchuk, Yuliia, additional, Pépin, Jean‐Louis, additional, Pétré, Benoit, additional, Picard, Robert, additional, Pitsios, Constantinos, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Raciborski, Filip, additional, Reitsma, Sietze, additional, Roche, Nicolas, additional, Rodriguez‐Gonzalez, Monica, additional, Romantowski, Jan, additional, Sá‐Sousa, Ana, additional, Serpa, Faradiba S., additional, Savouré, Marine, additional, Shamji, Mohamed H., additional, Sova, Milan, additional, Sperl, Annette, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Vandenplas, Olivier, additional, Van Eerd, Michiel, additional, Vasankari, Tuula, additional, Viart, Frédéric, additional, Waserman, Susan, additional, Fonseca, Joao A., additional, and Zuberbier, Torsten, additional
Published: 2023
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177. Cutoff Values of MASK-air Patient-Reported Outcome Measures

Author: Sousa-Pinto, Bernardo, primary, Sá-Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Pereira, Ana Margarida, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas-Linnemann, Desirée E., additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Ansotegui, Ignacio J., additional, Bosnic-Anticevich, Sinthia, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais-Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham-Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Taborda-Barata, Luis, additional, Toppila-Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
Published: 2022
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178. Changes in serum RANKL and OPG with sexual development and their associations with bone turnover and bone mineral density in a cohort of girls

Author: Lucas, Raquel, Ramos, Elisabete, Prata, Margarida, Rodrigues, Ana Maria, Costa, Lúcia, Severo, Milton, Canhão, Helena, Fonseca, João Eurico, and Barros, Henrique
Published: 2014
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179. Inhaler devices in asthma and COPD – An assessment of inhaler technique and patient preferences

Author: Chorão, Pedro, Pereira, Ana M., and Fonseca, João A.
Published: 2014
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180. Chapter 11 - Asthma in the digital world

Author: Bousquet, Jean, Sousa-Pinto, Bernardo, Puggioni, Francesca, Anto, Aram, Balli, Fabio, Casale, Thomas, Czarlewski, Wienczyslawa, Bedbrook, Anna, Brussino, Luisa, Gaga, Mina, Gemicioglu, Bilun, Klimek, Ludger, Kvedariene, Violeta, Louis, Renaud, Sastre, Joaquin, Scichilone, Nicola, Valiulis, Arunas, Zervas, Eleptherios, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M, Canonica, G Walter, and Fonseca, Joao A
Published: 2023
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181. Dark earths and the human built landscape in Amazonia: a widespread pattern of anthrosol formation

Author: Schmidt, Morgan J., Rapp Py-Daniel, Anne, de Paula Moraes, Claide, Valle, Raoni B.M., Caromano, Caroline F., Texeira, Wenceslau G., Barbosa, Carlos A., Fonseca, João A., Magalhães, Marcos P., Silva do Carmo Santos, Daniel, da Silva e Silva, Renan, Guapindaia, Vera L., Moraes, Bruno, Lima, Helena P., Neves, Eduardo G., and Heckenberger, Michael J.
Published: 2014
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182. An investigation of the environmental determinants of asthma hospitalizations: An applied spatial approach

Author: Ayres-Sampaio, Diogo, Teodoro, Ana C., Sillero, Neftalí, Santos, Cristina, Fonseca, João, and Freitas, Alberto
Published: 2014
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183. Pachydermoperiostosis in an African patient caused by a Chinese/Japanese SLCO2A1 mutation—Case report and review of literature

Author: Madruga Dias, João A.C., Rosa, Rita S., Perpétuo, Inês, Rodrigues, Ana M., Janeiro, André, Costa, Maria M., Gaião, Luís, Pereira da Silva, José A., Fonseca, João E., and Miltenberger-Miltenyi, Gabriel
Published: 2014
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184. Improvement of the Japan Meteorological Agency Meso-Scale Model for the Forecasting the Photovoltaic Power Production: Modification of the Cloud Scheme

Author: Shimose, Ken-ichi, Ohtake, Hideaki, Fonseca, Joao Gari da Silva, Jr., Takashima, Takumi, Oozeki, Takashi, and Yamada, Yoshinori
Published: 2014
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185. MASK‐air® direct patient data support the ARIA‐MeDALL hypothesis on allergic phenotypes.

Author: Bousquet, Jean, Sousa‐Pinto, Bernardo, Regateiro, Frederico S., Pereira, Ana Margarida, Brussino, Luisa, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Taborda‐Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Fonseca, Joao A., Zuberbier, Torsten, Anto, Josep M., Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, and Kupczyk, Maciej
Subjects: PHENOTYPES
Published: 2023
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186. Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

Author: Najm, Aurélie, Le Goff, Benoît, Orr, Carl, Thurlings, Rogier, Cañete, Juan D., Humby, Frances, Alivernini, Stefano, Manzo, Antonio, Just, Søren Andreas, Romão, Vasco C., Krenn, Veit, Müller-Ladner, Ulf, Addimanda, Olga, Tas, Sander W., Stoenoiu, Maria, Meric de Bellefon, Laurent, Durez, Patrick, Strand, Vibeke, Wechalekar, Mihir D., Fonseca, Joao E., Lauwerys, Bernard, Fearon, Ursula, Veale, Douglas J., and on behalf of EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group
Published: 2018
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187. Correction to: Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

Author: Najm, Aurélie, Le Goff, Benoît, Orr, Carl, Thurlings, Rogier, Cañete, Juan D., Humby, Frances, Alivernini, Stefano, Manzo, Antonio, Just, Søren Andreas, Romão, Vasco C., Krenn, Veit, Müller-Ladner, Ulf, Addimanda, Olga, Tas, Sander W., Stoenoiu, Maria, de Bellefon, Laurent Meric, Durez, Patrick, Strand, Vibeke, Wechalekar, Mihir D., Fonseca, Joao E., Lauwerys, Bernard, Fearon, Ursula, Veale, Douglas J., and on behalf of EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group
Published: 2018
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188. Measuring Microscale In-Plane Indentation Displacement Field for Material Characterization

Author: Han, Giyeol, Lee, Bohyeon, Fonseca, Joao Henrique, and Lee, Hyungyil
Abstract: A method measuring microscale in-plane indentation displacement field $\text{u}_{i}$ on the indented specimen surface is proposed by utilizing an optical flow (OF) algorithm. With images taken before and after indentation test, the calculated displacement field containing noise ( $\text{u}_{o}$ ) is computed using the OF algorithm. Due to the microvibration and the repositioning error after indentation test, the originally calculated $\text{u}_{o}$ contains the displacement error $\text{u}_{e}$ . Thus, $\text{u}_{e}$ is corrected using the origin-symmetric condition of indentation displacement field formed by the axisymmetric indenter. The effect of the grain size and the surface roughness of specimen on the $\text{u}_{i}$ field are also investigated. The corrected $\text{u}_{i}$ fields from the indentation tests for various materials (steel, copper, and aluminum) are verified by comparing to the indentation finite element analysis (FEA). After correcting the error $\text{u}_{e}$ , the average correlation coefficient $R^{2}$ between the displacement curve $\text{u}_{i}$ from the OF and the indentation FEA is 99% for all materials. Finally, it is concluded that the proposed method can measure the accurate in-plane indentation displacement field $\text{u}_{i}$ on a microscale.
Published: 2024
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189. Management of allergic rhinitis symptoms in the pharmacy Pocket guide 2022

Author: Lourenço, Olga, Cvetkovski, Biljana, Kritikos, Vicky, House, Rachel, Scheire, Sophie, Costa, Elísio, Fonseca, Joao A, Menditto, Enrica, Bedbrook, Anna, Bialek, Slawomir, Briedis, Vitalis, Boussery, Koen, Canonica, G. Walter, Haahtela, Tari, Kuna, Piotr, Mullol, Joaquim, Orlando, Valentina, Samolinski, Boleslaw, Wallace, Dana, Duggan, Catherine, Paulino, Ema, Pinto, Gonçalo S., Söderlund, Lars‐Åke, Bousquet, Jean, Bosnic‐Anticevich, Sinthia, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, Clinicum, University of Helsinki, uBibliorum, and Publica
Subjects: Pulmonary and Respiratory Medicine, allergic rhinitis, Allergy, IMPACT, pharmacist, Immunology, Biology and Life Sciences, QUALITY-OF-LIFE, 3121 General medicine, internal medicine and other clinical medicine, Medicine and Health Sciences, Immunology and Allergy, community pharmacy, ASTHMA, EPIDEMIOLOGY
Abstract: This research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors. Open access funding enabled and organized by Projekt DEAL, Background: Allergic rhinitis (AR) management requires a coordinated effort from healthcare providers and patients. Pharmacists are key members of these integrated care pathways resolving medication-related problems, optimizing regimens, improving adherence and recommending therapies while establishing liaisons between patients and physicians. Methods: Allergic Rhinitis and its Impact on Asthma (ARIA) first published a reference document on the pharmacist's role in allergic rhinitis management in 2004. Several guidelines were developed over the past 20 years improving the care of allergic rhinitis patients through an evidence-based, integrated care approach. Results: This ARIA/EAACI/FIP Position Paper is based on the latest ARIA in the Pharmacy guidelines and provides: (a) a structured approach to pharmacists identifying people with AR and/or allergic conjunctivitis as well as those at risk of poor disease control; (b) an evidence-based clinical decision support tool for optimising the management of allergic rhinitis in the community pharmacy; and (c) a framework of referral to the physician. Conclusion: This document is not intended to be a mandatory standard of care but is provided as a basis for pharmacists and their staff to develop relevant local standards of care for their patients, within their local practice environment. Pharmacy care varies between countries, and the guide should be adapted to the local situation.
Published: 2022

190. Understanding strain localisation behaviour in a near-α Ti-alloy during initial loading below the yield stress

Author: Dichtl Claudius, Lunt David, Thomas Rhys, Atkinson Michael, Thomas Matthew, Rugg Dave, Sandala Rebecca, Quinta da Fonseca Joao, and Preuss Michael
Subjects: Engineering (General). Civil engineering (General), TA1-2040
Abstract: Near-α Ti-alloys such as TIMETAL® 834 are known for their superior mechanical properties at high temperature, and as such are found in applications where high strength and improved fatigue performance at elevated temperatures (>450°C) are required. However, these alloys can be susceptible to cold-dwell fatigue; a failure mechanism that is not well understood. The present work investigates the strain localisation behaviour during cold creep and the implications it has in terms of dwell susceptibility for two different bi-modal microstructures. Slip traces and strain distributions have been analysed for different material conditions by employing High-Resolution Digital Image Correlation (HRDIC) in combination with orientation mapping. Using this approach, it was possible to distinguish deformation patterns in primary α grains and transformed-β colonies, loaded incrementally to stress levels of 70%, 80% and 90% of the yield stress. Different prior β-grain morphologies didn’t affect the average strains when stresses are low; but strain distributions have been affected by the β-grain morphology. Material with coarse transformation product accumulated larger amounts of plastic strain compared to material with fine transformation product, at the same relative stress levels. At low stress levels, slip bands have been detected both in primary α, as well in the transformed-β phase, cutting through the lamellae, for the material condition with a coarse transformation product; on the other hand, for the material conditions with a fine transformation product, slip bands are localised only in primary α grains at low stress levels. It was also found for both conditions that at low stress levels slip bands are found in grains that are well oriented for basal slip. Based on these observations it is discussed if b-ligaments are significant obstacles to dislocation movement. Finally, the requirement of crystal-plasticity modelling to take into account differences in crystallographic orientations and the elastic and plastic anisotropy of HCP-titanium will be discussed and considered.
Published: 2020
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191. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK‐air® longitudinal study

Author: Sousa‐Pinto, Bernardo, primary, Schünemann, Holger J., additional, Sá‐Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Agache, Ioana, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Eklund, Patrik, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Ispayeva, Zhanat, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Lipworth, Brian, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Todo‐Bom, Ana, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Vandenplas, Olivier, additional, Wallace, Dana, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
Published: 2022
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192. Applicability of the MASK-Air® App to Severe Asthma Treated with Biologic Molecules: A Pilot Study

Author: Benfante, Alida, primary, Sousa-Pinto, Bernardo, additional, Pillitteri, Gianluca, additional, Battaglia, Salvatore, additional, Fonseca, Joao, additional, Bousquet, Jean, additional, and Scichilone, Nicola, additional
Published: 2022
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193. Drilling a investigative well in the auxiliary rotary table in a dual activity rig

Author: De Lima, Flank Melo, primary, Percy, Joseir Gandra, additional, Cunha, Diogo, additional, Sortica, Emanuel Apoema, additional, Falcão, Flávia de Oliveira Lima, additional, Rodrigues, Bruno Fidalgo Telles, additional, França, Rafael Lopez, additional, Da Fonseca, Joao Paulo Teixeira, additional, Pereira, Marcos Vinicius, additional, and Mocelin, Sidarta, additional
Published: 2022
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194. EPI-ASTHMA study protocol: a population-based multicentre stepwise study on the prevalence and characterisation of patients with asthma according to disease severity in Portugal

Author: Jácome, Cristina, primary, Brito, Dinis, additional, João, Catarina, additional, Lopes, Filipa, additional, Santos, Janete, additional, Amorim, Liliana, additional, Barbosa, Maria João, additional, Pardal, Marisa, additional, Teixeira, Pedro, additional, Bernardo, Filipa, additional, Fonseca, Joao A, additional, and Correia-de-Sousa, Jaime, additional
Published: 2022
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195. Accuracy of the solar irradiance forecasts of the Japan Meteorological Agency mesoscale model for the Kanto region, Japan

Author: Ohtake, Hideaki, Shimose, Ken-ichi, Fonseca, Joao Gari da Silva, Jr., Takashima, Takumi, Oozeki, Takashi, and Yamada, Yoshinori
Published: 2013
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196. Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Author: Malinovschi, Andrei, Fonseca, João A., Jacinto, Tiago, Alving, Kjell, and Janson, Christer
Published: 2013
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197. The effect of γ′ size and alloy chemistry on dynamic strain ageing in advanced polycrystalline nickel base superalloys

Author: Grant, Benedict M.B., Francis, Elisabeth M., da Fonseca, João Quinta, Preuss, Michael, and Daymond, Mark R.
Published: 2013
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198. Mechanical behavior of high strength granite for new prestressed stone structures

Author: Pinto, Clemente and Fonseca, João
Published: 2013
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199. PlanPAS - Plans Parser for Automated Systems

Author: da Silva Fonseca, João Paulo, de Souza, Alexandre Rodrigues, Ferreira, Marco Vinícius Muniz, de Souza Tavares, José Jean-Paul Zanlucchi, and Carvalho, João Carlos Mendes
Published: 2013
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200. The North's Growing Role in South—South Cooperation: keeping the foothold

Author: ABDENUR, ADRIANA ERTHAL and DA FONSECA, JOÃO MOURA ESTEVÃO MARQUES
Published: 2013
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