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156. Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels

Author

Sennblad, Bengt, Basu, Saonli, Mazur, Johanna, Suchon, Pierre, Martinez-Perez, Angel, van Hylckama Vlieg, Astrid, Truong, Vinh, Li, Yuhuang, Gådin, Jesper R., Tang, Weihong, Grossman, Vera, de Haan, Hugoline G., Handin, Niklas, Silveira, Angela, Souto, Juan Carlos, Franco-Cereceda, Anders, Morange, Pierre-Emmanuel, Gagnon, France, Soria, Jose Manuel, Eriksson, Per, Hamsten, Anders, Maegdefessel, Lars, Rosendaal, Frits R., Wild, Philipp, Folsom, Aaron R., Trégouët, David-Alexandre, and Sabater-Lleal, Maria

Published
2017
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159. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

Author

Huang, Jie, Sabater-Lleal, Maria, Asselbergs, Folkert W., Tregouet, David, Shin, So-Youn, Ding, Jingzhong, Baumert, Jens, Oudot-Mellakh, Tiphaine, Folkersen, Lasse, Johnson, Andrew D., Smith, Nicholas L., Williams, Scott M., Ikram, Mohammad A., Kleber, Marcus E., Becker, Diane M., Truong, Vinh, Mychaleckyj, Josyf C., Tang, Weihong, Yang, Qiong, Sennblad, Bengt, Moore, Jason H., Williams, Frances M.K., Dehghan, Abbas, Silbernagel, Günther, Schrijvers, Elisabeth M.C., Smith, Shelly, Karakas, Mahir, Tofler, Geoffrey H., Silveira, Angela, Navis, Gerjan J., Lohman, Kurt, Chen, Ming-Huei, Peters, Annette, Goel, Anuj, Hopewell, Jemma C., Chambers, John C., Saleheen, Danish, Lundmark, Per, Psaty, Bruce M., Strawbridge, Rona J., Boehm, Bernhard O., Carter, Angela M., Meisinger, Christa, Peden, John F., Bis, Joshua C., McKnight, Barbara, Öhrvik, John, Taylor, Kent, Franzosi, Maria Grazia, Seedorf, Udo, Collins, Rory, Franco-Cereceda, Anders, Syvänen, Ann-Christine, Goodall, Alison H., Yanek, Lisa R., Cushman, Mary, Müller-Nurasyid, Martina, Folsom, Aaron R., Basu, Saonli, Matijevic, Nena, van Gilst, Wiek H., Kooner, Jaspal S., Hofman, Albert, Danesh, John, Clarke, Robert, Meigs, James B., Kathiresan, Sekar, Reilly, Muredach P., Klopp, Norman, Harris, Tamara B., Winkelmann, Bernhard R., Grant, Peter J., Hillege, Hans L., Watkins, Hugh, Spector, Timothy D., Becker, Lewis C., Tracy, Russell P., März, Winfried, Uitterlinden, Andre G., Eriksson, Per, Cambien, Francois, Morange, Pierre-Emmanuel, Koenig, Wolfgang, Soranzo, Nicole, van der Harst, Pim, Liu, Yongmei, O'Donnell, Christopher J., and Hamsten, Anders

Published
2012
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162. Whole-exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors

Author

Pankratz, Nathan, primary, Wei, Peng, additional, Brody, Jennifer A, additional, Chen, Ming-Huei, additional, de Vries, Paul S, additional, Huffman, Jennifer E, additional, Stimson, Mary Rachel, additional, Auer, Paul L, additional, Boerwinkle, Eric, additional, Cushman, Mary, additional, de Maat, Moniek P M, additional, Folsom, Aaron R, additional, Franco, Oscar H, additional, Gibbs, Richard A, additional, Haagenson, Kelly K, additional, Hofman, Albert, additional, Johnsen, Jill M, additional, Kovar, Christie L, additional, Kraaij, Robert, additional, McKnight, Barbara, additional, Metcalf, Ginger A, additional, Muzny, Donna, additional, Psaty, Bruce M, additional, Tang, Weihong, additional, Uitterlinden, André G, additional, van Rooij, Jeroen G J, additional, Dehghan, Abbas, additional, O'Donnell, Christopher J, additional, Reiner, Alex P, additional, Morrison, Alanna C, additional, and Smith, Nicholas L, additional

Published
2022
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163. Obesity, Galectin‐3, and Incident Heart Failure: The ARIC Study

Author

Florido, Roberta, primary, Kwak, Lucia, additional, Echouffo‐Tcheugui, Justin B., additional, Zhang, Sui, additional, Michos, Erin D., additional, Nambi, Vijay, additional, Goldberg, Ronald B., additional, Hoogeveen, Ron C., additional, Lazo, Mariana, additional, Gerstenblith, Gary, additional, Post, Wendy S., additional, Blumenthal, Roger S., additional, Coresh, Josef, additional, Folsom, Aaron R., additional, Selvin, Elizabeth, additional, Ballantyne, Christie, additional, and Ndumele, Chiadi E., additional

Published
2022
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164. HISTORY OF RISK FACTOR CONTROL AND INCIDENT HEART FAILURE: THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY (ARIC)

Author

Hamo, Carine, primary, Zhang, Sui, additional, Wang, Dan, additional, Florido, Roberta, additional, Echouffo-Tcheugui, Justin, additional, Blumenthal, Roger S., additional, Loehr, Laura, additional, Matsushita, Kunihiro, additional, Nambi, Vijay, additional, Ballantyne, Christie M., additional, Selvin, Elizabeth, additional, Folsom, Aaron R., additional, Heiss, Gerardo –, additional, Coresh, Josef, additional, and Ndumele, Chiadi E., additional

Published
2022
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169. The Association of Sport and Exercise Activities With Cardiovascular Disease Risk: The Atherosclerosis Risk in Communities (ARIC) Study.

Author

Porter, Anna K., Schilsky, Samantha, Evenson, Kelly R., Florido, Roberta, Palta, Priya, Holliday, Katelyn M., and Folsom, Aaron R.

Subjects
PHYSICAL activity, CARDIOVASCULAR diseases, EXERCISE, CORONARY disease, HEART failure
Abstract

Background: This study assessed the independent associations between participation in self-reported sport and exercise activities and incident cardiovascular disease (CVD). Methods: Data were from 13,204 participants in the Atherosclerosis Risk in Communities Study cohort (1987-2015). Baseline sport and exercise activities were assessed via the modified Baecke questionnaire. Incident CVD included coronary heart disease, heart failure, or stroke. Multivariable-adjusted Cox proportional hazard models assessed the association of participation in specific sport and exercise activities at enrollment with risk of CVD. Results: During amedian follow-up time of 25.2 years, 30% of the analytic sample (n = 3966) was diagnosed with incident CVD. In fully adjusted models, participation in racquet sports (hazard ratio [HR] 0.75; 95% confidence interval [CI], 0.61-0.93), aerobics (HR 0.75; 95% CI, 0.63-0.88), running (HR 0.68; 95% CI, 0.54-0.85), and walking (HR 0.89; 95% CI, 0.83-0.95) was significantly associated with a lower risk of CVD. There were no significant associations for bicycling, softball/baseball, gymnastics, swimming, basketball, calisthenics exercises, golfing with cart, golfing with walking, bowling, or weight training. Conclusions: Participation in specific sport and exercises may substantially reduce the risk for CVD. [ABSTRACT FROM AUTHOR]

Published
2019
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170. Television Watching as Sedentary Behavior and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study.

Author

Kubota, Yasuhiko, Alonso, Alvaro, Shah, Amil M., Chen, Lin Y., and Folsom, Aaron R.

Subjects
DISEASE prevalence, PHYSICAL activity, ATRIAL fibrillation, CARDIOVASCULAR diseases, PHYSICAL fitness
Abstract

Background: There is no research on the association of television (TV) watching with atrial fibrillation (AF). Methods: From 1987 to 1989, the authors obtained information on the frequency of TV watching in 14,458 participants, aged 45–64 years, without a history of AF. The authors used the Cox proportional hazards model to estimate hazard ratios and their 95% confidence intervals of AF according to the frequency of TV watching ("never or seldom," "sometimes," "often," or "very often"). Results: During the 294,553 person-years of follow-up, the authors identified 2,476 AF events. Adjustment for other potential confounding factors, including physical activity, did not change the associations, in which "very often" watching TV carried 1.28 (95% confidence interval, 1.09–1.50) times AF risk compared with "never or seldom" watching TV (P for trend =.002). Even among individuals who met a recommended level of physical activity, watching TV "very often" carried 1.36 (1.02–1.82) times AF risk, compared with watching TV "never or seldom." Conclusion: Greater frequency of TV watching was independently associated with increased risk of AF even after adjusting for physical activity. Moreover, a recommended level of physical activity did not eliminate the increased risk of frequent TV watching for AF. Avoiding frequent TV watching might be beneficial for AF prevention. [ABSTRACT FROM AUTHOR]

Published
2018
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174. Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe)

Author

Wassel, Christina L., Lange, Leslie A., Keating, Brendan J., Taylor, Kira C., Johnson, Andrew D., Palmer, Cameron, Ho, Lindsey A., Smith, Nicholas L., Lange, Ethan M., Li, Yun, Yang, Qiong, Delaney, Joseph A., Tang, Weihong, Tofler, Geoffrey, Redline, Susan, Taylor, Herman A., Jr, Wilson, James G., Tracy, Russell P., Jacobs, David R., Jr, Folsom, Aaron R., Green, David, O'Donnell, Christopher J., and Reiner, Alexander P.

Published
2011
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178. Heart Failure Risk Associated With Severity of Modifiable Heart Failure Risk Factors: The ARIC Study

Author

Hamo, Carine E., primary, Kwak, Lucia, additional, Wang, Dan, additional, Florido, Roberta, additional, Echouffo‐Tcheugui, Justin B., additional, Blumenthal, Roger S., additional, Loehr, Laura, additional, Matsushita, Kunihiro, additional, Nambi, Vijay, additional, Ballantyne, Christie M., additional, Selvin, Elizabeth, additional, Folsom, Aaron R., additional, Heiss, Gerardo, additional, Coresh, Josef, additional, and Ndumele, Chiadi E., additional

Published
2022
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182. Assessing Risk Prediction Models Using Individual Participant Data From Multiple Studies

Author

Pennells, Lisa, Kaptoge, Stephen, White, Ian R., Thompson, Simon G., Wood, Angela M., Tipping, Robert W., Folsom, Aaron R., Couper, David J., Ballantyne, Christie M., Coresh, Josef, Goya Wannamethee, S., Morris, Richard W., Kiechl, Stefan, Willeit, Johann, Willeit, Peter, Schett, Georg, Ebrahim, Shah, Lawlor, Debbie A., Yarnell, John W., Gallacher, John, Cushman, Mary, Psaty, Bruce M., Tracy, Russ, Tybjærg-Hansen, Anne, Price, Jackie F., Lee, Amanda J., McLachlan, Stela, Khaw, Kay-Tee, Wareham, Nicholas J., Brenner, Hermann, Schöttker, Ben, Müller, Heiko, Jansson, Jan-Håkan, Wennberg, Patrik, Salomaa, Veikko, Harald, Kennet, Jousilahti, Pekka, Vartiainen, Erkki, Woodward, Mark, DʼAgostino, Ralph B., Bladbjerg, Else-Marie, Jørgensen, Torben, Kiyohara, Yutaka, Arima, Hisatomi, Doi, Yasufumi, Ninomiya, Toshiharu, Dekker, Jacqueline M., Nijpels, Giel, Stehouwer, Coen D. A., Kauhanen, Jussi, Salonen, Jukka T., Meade, Tom W., Cooper, Jackie A., Cushman, Mary, Folsom, Aaron R., Psaty, Bruce M., Shea, Steven, Döring, Angela, Kuller, Lewis H., Grandits, Greg, Gillum, Richard F., Mussolino, Michael, Rimm, Eric B., Hankinson, Sue E., Manson, JoAnn E., Pai, Jennifer K., Kirkland, Susan, Shaffer, Jonathan A., Shimbo, Daichi, Bakker, Stephan J. L., Gansevoort, Ron T., Hillege, Hans L., Amouyel, Philippe, Arveiler, Dominique, Evans, Alun, Ferrières, Jean, Sattar, Naveed, Westendorp, Rudi G., Buckley, Brendan M., Cantin, Bernard, Lamarche, Benoît, Barrett-Connor, Elizabeth, Wingard, Deborah L., Bettencourt, Richele, Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Kavousi, Maryam, Witteman, Jacqueline C., Hofman, Albert, Franco, Oscar H., Howard, Barbara V., Zhang, Ying, Best, Lyle, Umans, Jason G., Onat, Altan, Sundström, Johan, Michael Gaziano, J., Stampfer, Meir, Ridker, Paul M., Michael Gaziano, J., Ridker, Paul M., Marmot, Michael, Clarke, Robert, Collins, Rory, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Kivimäki, Mika, Ridker, Paul M., Buring, Julie, Cook, Nancy, Ford, Ian, Shepherd, James, Cobbe, Stuart M., Robertson, Michele, Walker, Matthew, Watson, Sarah, Alexander, Myriam, Butterworth, Adam S., Angelantonio, Emanuele Di, Gao, Pei, Haycock, Philip, Kaptoge, Stephen, Pennells, Lisa, Thompson, Simon G., Walker, Matthew, Watson, Sarah, White, Ian R., Wood, Angela M., Wormser, David, and Danesh, John

Published
2014
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188. A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

Author

de Vries, Paul S., Chasman, Daniel I., Sabater-Lleal, Maria, Chen, Ming-Huei, Huffman, Jennifer E., Steri, Maristella, Tang, Weihong, Teumer, Alexander, Marioni, Riccardo E., Grossmann, Vera, Hottenga, Jouke J., Trompet, Stella, Müller-Nurasyid, Martina, Zhao, Jing Hua, Brody, Jennifer A., Kleber, Marcus E., Guo, Xiuqing, Wang, Jie Jin, Auer, Paul L., Attia, John R., Yanek, Lisa R., Ahluwalia, Tarunveer S., Lahti, Jari, Venturini, Cristina, Tanaka, Toshiko, Bielak, Lawrence F., Joshi, Peter K., Rocanin-Arjo, Ares, Kolcic, Ivana, Navarro, Pau, Rose, Lynda M., Oldmeadow, Christopher, Riess, Helene, Mazur, Johanna, Basu, Saonli, Goel, Anuj, Yang, Qiong, Ghanbari, Mohsen, Willemsen, Gonneke, Rumley, Ann, Fiorillo, Edoardo, de Craen, Anton J. M., Grotevendt, Anne, Scott, Robert, Taylor, Kent D., Delgado, Graciela E., Yao, Jie, Kifley, Annette, Kooperberg, Charles, Qayyum, Rehan, Lopez, Lorna M., Berentzen, Tina L., Räikkönen, Katri, Mangino, Massimo, Bandinelli, Stefania, Peyser, Patricia A., Wild, Sarah, Trégouët, David-Alexandre, Wright, Alan F., Marten, Jonathan, Zemunik, Tatijana, Morrison, Alanna C., Sennblad, Bengt, Tofler, Geoffrey, de Maat, Moniek P. M., de Geus, Eco J. C., Lowe, Gordon D., Zoledziewska, Magdalena, Sattar, Naveed, Binder, Harald, Völker, Uwe, Waldenberger, Melanie, Khaw, Kay-Tee, Mcknight, Barbara, Huang, Jie, Jenny, Nancy S., Holliday, Elizabeth G., Qi, Lihong, Mcevoy, Mark G., Becker, Diane M., Starr, John M., Sarin, Antti-Pekka, Hysi, Pirro G., Hernandez, Dena G., Jhun, Min A., Campbell, Harry, Hamsten, Anders, Rivadeneira, Fernando, Mcardle, Wendy L., Slagboom, P. Eline, Zeller, Tanja, Koenig, Wolfgang, Psaty, Bruce M., Haritunians, Talin, Liu, Jingmin, Palotie, Aarno, Uitterlinden, André G., Stott, David J., Hofman, Albert, Franco, Oscar H., Polasek, Ozren, Rudan, Igor, Morange, Pierre-Emmanuel, Wilson, James F., Kardia, Sharon L. R., Ferrucci, Luigi, Spector, Tim D., Eriksson, Johan G., Hansen, Torben, Deary, Ian J., Becker, Lewis C., Scott, Rodney J., Mitchell, Paul, März, Winfried, Wareham, Nick J., Peters, Annette, Greinacher, Andreas, Wild, Philipp S., Jukema, J. Wouter, Boomsma, Dorret I., Hayward, Caroline, Cucca, Francesco, Tracy, Russell, Watkins, Hugh, Reiner, Alex P., Folsom, Aaron R., Ridker, Paul M., OʼDonnell, Christopher J., Smith, Nicholas L., Strachan, David P., and Dehghan, Abbas

Published
2016
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199. Association of Differential Leukocyte Count With Incident Abdominal Aortic Aneurysm Over 22.5 Years: The Atherosclerosis Risk in Communities Study

Author

Parikh, Romil R., Folsom, Aaron R., Poudel, Kripa, Lutsey, Pamela L., Demmer, Ryan T., Pankow, James S., Chen, Lin Y., and Tang, Weihong

Subjects
Male, Time Factors, Incidence, Middle Aged, Prognosis, Risk Assessment, Article, United States, Leukocyte Count, Predictive Value of Tests, Risk Factors, Leukocytes, Humans, Female, Prospective Studies, Aortic Aneurysm, Abdominal
Abstract

OBJECTIVE: Leukocytes contribute to the development of abdominal aortic aneurysm (AAA). We evaluated whether associations of differential leukocyte counts with AAA persist after accounting for traditional risk factors of AAA. APPROACH AND RESULTS: Among 11 217 adults from the Atherosclerosis Risk in Communities Study, we evaluated associations of differential leukocyte counts at baseline (1987–1989) with incident AAAs over a median follow-up of 22.5 years, using Cox proportional hazards regression. Each differential leukocyte count was categorized into 5 groups—below normal, tertiles within the normal range, and above normal, with the first tertile serving as the referent. We identified 377 incident AAAs through 2011, using hospital discharge diagnoses, linked Medicare records, or death certificates. At baseline, higher neutrophil, monocyte, and eosinophil counts were associated with higher risk of AAA, independent of smoking, other differential leukocyte counts, and other traditional risk factors. The association with incident AAA was the strongest for above normal neutrophil count, with an adjusted hazard ratio (95% CI) of 2.17 (1.29–3.64). Below normal neutrophil, lymphocyte, eosinophil and basophil counts were associated with higher risk of AAA with adjusted hazard ratio (95% CI) between 1.86 (1.04–3.35) and 1.62 (1.10–2.39). CONCLUSIONS: Higher neutrophil, monocyte, and eosinophil counts in midlife are associated with higher risk of AAA, even after accounting for traditional risk factors such as smoking, obesity, and atherosclerosis. This suggests the need to identify nontraditional risk factors and treatment strategies to mitigate the residual risk of AAA conferred by midlife inflammation. Whether immunosuppression is associated with higher risk of AAA needs further investigation.

Published
2021

200. The Atherosclerosis Risk in Communities (ARIC) study: JACC Focus Seminar 3/8

Author

Wright, Jacqueline D., Folsom, Aaron R., Coresh, Josef, Sharrett, A. Richey, Couper, David, Wagenknecht, Lynne E., Mosley, Thomas H., Ballantyne, Christie M., Boerwinkle, Eric A., Rosamond, Wayne D., and Heiss, Gerardo

Subjects
Residence Characteristics, Risk Factors, Incidence, Population Surveillance, Cardiology, Humans, Periodicals as Topic, Atherosclerosis, Article, United States
Abstract

ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, genomics, heart failure, and prevention, producing more than 2,300 publications. Results have had strong clinical impact and demonstrate the importance of population-based research in the spectrum of biomedical research to improve health.

Published
2021

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