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153. Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry

Author

Cremon, Cesare, Carabotti, Marilia, Cuomo, Rosario, Pace, Fabio, Andreozzi, Paolo, Barbaro, Maria Raffaella, Annibale, Bruno, Barbara, Giovanni, Andrealli, Alida, Andriulli, Angelo, Ardizzone, Sandro, Astegiano, Marco, Bachetti, Francesco, Bartolozzi, Simona, Bargiggia, Stefano, Bassotti, Gabrio, Bianco, Maria Antonia, Binda, Gian Andrea, Biscaglia, Giuseppe, Bosani, Matteo, Bottiglieri, Maria Erminia, Cargiolli, Martina, Ciacci, Carolina, Colecchia, Antonio, Dell’Era, Alessandra, De Matthaeis, Marina, Dinelli, Marco, Festa, Virginia, Festi, Davide, Galliani, Ermenegildo, Garribba, Alessandra, Germana’, Bastianello, Grassini, Mario, Guido, Ennio, Iafrate, Franco, Iovino, Paola, Iuliano, Donato, Laghi, Andrea, Latella, Giovanni, Lorusso, Michele, Manes, Giampiero, Marchi, Santino, Mauro, Biagio, Maurano, Attilio, Nascimbeni, Riccardo, Neri, Matteo, Occhipinti, Pietro, Parravicini, Marco, Pennazio, Marco, Peralta, Sergio, Portincasa, Piero, Radaelli, Franco, Rossi, Marco, Salerno, Raffale, Savarino, Vincenzo, Segato, Sergio, Severi, Carola, Scaccianoce, Giuseppe, Usai, Paolo, Valle, Valentina, Virgilio, Clara, and Viscido, Angelo

Abstract

Background Although diverticular disease is a common condition, its effective treatment is challenging in clinical practice.Objective The objective of this article is to assess pharmacological management in different clinical settings of diverticular disease and factors associated with treatment using the Italian registry Registro Malattia Diverticolare (REMAD).Methods At study enrolment, patients were categorised into subgroups: diverticulosis, symptomatic uncomplicated diverticular disease and previous diverticulitis. We registered demographic, clinical and lifestyle factors, quality of life and the use of treatments for diverticular disease in the last year. Logistic regression analysis assessed the association between clinical factors and treatment consumption.Results A total of 500 of the 1206 individuals included had had at least one treatment for diverticular disease in the last year: 23.6% (166/702) of patients with diverticulosis, 55.9% (165/295) of patients with symptomatic diverticular disease, and 80.9% (169/209) of patients with previous diverticulitis (p< 0.001). In multivariate analysis, the following factors were significantly associated with treatment use: female gender, family history of colonic diverticula, organic digestive comorbidity and impaired physical quality of life components.Conclusion Individuals with diverticular disease take medications based on the different clinical settings of disease. We identified different features associated with treatment use in the distinct clinical entities of diverticular disease. ClinicalTrial.gov Identifier:NCT03325829.

Published
2019
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154. DPR 137/12: Non abolisce gli ordini, ma diversifica le funzioni

Author

FESTI, DAVIDE, MALATESTA, MARIA, D. Festi, and M. Malatesta

Subjects
professioni, DPR 137/12, sistema sanitario
Abstract

L'articolo esamina i processi di riforma delle libere professioni italiane focalizzando l'attenzione sul DPR 137/12, comparando il campo giuridico con quello sanitario e analizzando il ruolo amrginale che la nuova legislazione affida all'università.

Published
2012

155. Treatment of nonalcoholic fatty liver with focus on emerging drugs

Author

MARCHESINI REGGIANI, GIULIO, MOSCATIELLO, SIMONA, AGOSTINI, FEDERICA, VILLANOVA, NICOLA, FESTI, DAVIDE, G. Marchesini Reggiani, S. Moscatiello, F. Agostini, N. Villanova, and D. Festi

Subjects
WEIGHT LOSS, cytoprotective agent, nonalcoholic fatty liver, angiotensin-receptor blockers, insulin sensitizer, Anti-oxidant, incretin
Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is becoming one of the most common causes of chronic liver disease worldwide. The economic and social cost of disease is very high and there is a need for effective treatments. Areas covered: The available and potential future treatments for NAFLD are reviewed. Expert opinion: Weight loss remains the cornerstone of treatment of hepatic steatosis, but difficult to pursue. A pragmatic approach relies on generic recommendations for weight loss and physical activity in the whole population and limiting interventions to subject at risk of disease progression, but the type of preferred treatment remains a matter of debate. The large number and mechanistic diversity of drugs that have so far been investigated bear testimony to the lack of a specific, effective agent. Insulin resistance remains the pivotal alteration responsible for liver disease and its progression and insulin sensitizers are regarded as the treatment of choice. Several ongoing studies are testing the effectiveness of new approaches on histological outcomes and new metabolic pathways are under scrutiny.

Published
2011

161. 142 Neuro-Immune Interactions in Patients With Diverticular Disease

Author

Cremon, Cesare, primary, Barbaro, M. Raffaella, additional, Scaioli, Eleonora, additional, Marasco, Giovanni, additional, Carapelle, Marianna, additional, Elena, Benatti, additional, Colecchia, Antonio, additional, Festi, Davide, additional, Stanghellini, Vincenzo, additional, and Barbara, Giovanni, additional

Published
2015
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162. Reply to Letter

Author

Cescon, Matteo, primary, Cucchetti, Alessandro, additional, Colecchia, Antonio, additional, Ercolani, Giorgio, additional, Festi, Davide, additional, and Pinna, Antonio Daniele, additional

Published
2015
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166. Treatment of acute hepatitis B with high dose lamivudine

Author

F. Lodato, A. Lisotti, M. Di Girolamo, F. Buonfiglioli, V. Feletti, A. Colecchia, C. Granci, FESTI, DAVIDE, AZZAROLI, FRANCESCO, CECINATO, PAOLO, MONTAGNANI, MARCO, RODA, ENRICO, MAZZELLA, GIUSEPPE, F. Lodato, A. Lisotti, M. Di Girolamo, F. Buonfiglioli, D. Festi, F. Azzaroli, V. Feletti, P. Cecinato, A. Colecchia, M. Montagnani, C. Granci, E. Roda, and G. Mazzella

Subjects
HEPATITIS B, ACUTE, TREATMENT, LAMIVUDINE
Published
2008

167. G-CSF administration is not related to Peg-IFN alfa-2b treatment duration nor response in liver transplanted patients with HCV recurrence

Author

F. Lodato, M. R. Tamè, M. Di Girolamo, GRAMENZI, ANNAGIULIA, S. Berardi, AZZAROLI, FRANCESCO, ANDREONE, PIETRO, PINNA, ANTONIO DANIELE, RODA, ENRICO, FESTI, DAVIDE, MAZZELLA, GIUSEPPE, F. Lodato, M.R. Tamè, M. Di Girolamo, F. Azzaroli, A. Gramenzi, S. Berardi, P. Andreone, A.D. Pinna, E. Roda, D. Festi, and G. Mazzella

Subjects
INTERFERON, G-CSF, TRANSPLANTATION, HEPATITIS C, RECURRENCE
Published
2008

168. Hypertransaminasemia and pregnancy outcome

Author

AZZAROLI, FRANCESCO, M. Di Girolamo, F. Lodato, CECINATO, PAOLO, V. Feletti, F. Alessandrelli, PELUSI, GIUSEPPE, A. Colecchia, FESTI, DAVIDE, RODA, ENRICO, MAZZELLA, GIUSEPPE, F. Azzaroli, M. Di Girolamo, F. Lodato, P. Cecinato, V. Feletti, F. Alessandrelli, G. Pelusi, A. Colecchia, D. Festi, E. Roda, and G. Mazzella

Subjects
OUTCOME, PREGNANCY, TRANSAMINASES
Published
2008

169. Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid

Author

Azzaroli, Francesco, Mennone, A., Feletti, Valentina, Simoni, Patrizia, Baglivo, E., Montagnani, Marco, Rizzo, Nicola, Pelusi, Giuseppe, DE ALOYSIO, Domenico, Lodato, Francesca, Festi, Davide, Colecchia, Antonio, Roda, Enrico, Boyer, J. L., Mazzella, Giuseppe, Azzaroli F., Mennone A., Feletti V., Simoni P., Baglivo E., Montagnani M., Rizzo N., Pelusi G., DE Aloysio D., Lodato F., Festi D., Colecchia A., Roda E., Boyer J.L., and Mazzella G.

Subjects
Bile Acids and Salts, Pregnancy Complications, ATP Binding Cassette Transporter, Subfamily B, Pregnancy, Placenta, Ursodeoxycholic Acid, Infant, Newborn, Humans, Bilirubin, Female
Abstract

The effects of ursodeoxycholic acid on human placental bile acids and bilirubin transporters in intrahepatic cholestasis of pregnancy are still undefined.To evaluate whether ursodeoxycholic acid affects MRP2, MRP3 and MRP4 expression in the placenta.Forty-three pregnant women were enrolled; fourteen subjects had physiological pregnancies. Intrahepatic cholestasis of pregnancy patients were divided into two groups: (i) 13 received ursodeoxycholic acid (20 mg/kg/day) and (ii) 16 untreated. Total bile acid and bilirubin in serum and cord blood were determined in each subject. Multidrug resistance proteins expression (immunoblot, quantitative real-time PCR) was evaluated in placentas collected at delivery. anova test was used for statistical analysis of data.Ursodeoxycholic acid administration significantly improved maternal serum bile acid and cord blood bilirubin and bile acid levels. MRP2 protein and RNA expression was significantly increased in placentas from treated patients compared to controls (P0.001 and P0.01, respectively). MRP3 protein expression was not significantly different between the groups while RNA expression was significantly decreased in treated patients (P0.01). MRP4 did not show significant differences between the groups.Ursodeoxycholic acid administration induces placental MRP2 expression, and reduces bilirubin and bile acid levels in cord blood.

Published
2007

170. Effects of UDCA on the foetus-maternal circulation of bilirubin in cholestasis of pregnancy

Author

AZZAROLI, FRANCESCO, RIZZO, NICOLA, DE ALOYSIO, DOMENICO, PELUSI, GIUSEPPE, MONTAGNANI, MARCO, FESTI, DAVIDE, COLECCHIA, ANTONIO, RODA, ALDO, RODA, ENRICO, MAZZELLA, GIUSEPPE, E. Baglivo, V. Feletti, M. Locatelli, F. Lodato, F. Azzaroli, E. Baglivo, V. Feletti, M. Locatelli, N. Rizzo, D. De Aloysio, G. Pelusi, M. Montagnani, F. Lodato, D. Festi, A. Colecchia, A. Roda, E. Roda, and G. Mazzella

Subjects
PREGNANCY, Hepatology, BILIRUBIN, FETUS, Gastroenterology, CIRCULATION, CHOLESTASIS, BILE ACIDS
Published
2007

171. Colecistosi e tumori della colecisti

Author

COLECCHIA, ANTONIO, VESTITO, AMANDA, FESTI, DAVIDE, A. Nikiforaki, C.SCHIAVONE,M.ROMANO, A.Colecchia, A.Vestito, A.Nikiforaki, and D.Festi

Abstract

Principali quadri ecografici della patologia colecistica

Published
2007

178. Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease.

Author

Barbara, Giovanni, Scaioli, Eleonora, Barbaro, Maria Raffaella, Biagi, Elena, Laghi, Luca, Cremon, Cesare, Marasco, Giovanni, Colecchia, Antonio, Picone, Gianfranco, Salfi, Nunzio, Capozzi, Francesco, Brigidi, Patrizia, and Festi, Davide

Subjects
INTESTINAL diseases, DIVERTICULOSIS, COLONOSCOPY, IMMUNOHISTOCHEMISTRY, DIAGNOSIS, DISEASE risk factors
Published
2017
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179. Regolazione dei trasportatori placentari degli acidi biliari MRP2, MRP3, MRP4 da parte dell’acido ursodesossicolico in corso di colestasi gravidica

Author

AZZAROLI, FRANCESCO, FELETTI, VALENTINA, SIMONI, PATRIZIA, RIZZO, NICOLA, SANTARSIERO, GIUSEPPE, FRANCHINA, MICHELE, LODATO, FRANCESCA, FESTI, DAVIDE, COLECCHIA, ANTONIO, RODA, ALDO, RODA, ENRICO, MAZZELLA, GIUSEPPE, M. Magliuolo, E. Baglivo, JL Boyer, F. Azzaroli, V. Feletti, P. Simoni, M. Magliuolo, E. Baglivo, N. Rizzo, G. Santarsiero, M. Franchina, F. Lodato, D. Festi, A. Colecchia, A. Roda, E. Roda, JL Boyer, and G. Mazzella

Subjects
GRAVIDANZA, ACIDO URSODEOSSICOLICO, COLESTASI, MRP
Published
2005

180. Mathematical model predicting high hepatocyte proliferation index and risk of HCC in patients with HCV related cirrhosis: a proposal for clinical validation

Author

Azzaroli, Francesco, Colecchia, Antonio, Lodato, Francesca, Montagnani, Marco, BACCHI REGGIANI, MARIA LETIZIA, Festi, Davide, Feletti, Valentina, Prati, G. M., Accogli, E., Casanova, Silvia, Derenzini, Massimo, Roda, Enrico, Mazzella, Giuseppe, F. Azzaroli, A. Colecchia, F. Lodato, M. Montagnani, ML. Bacchi Reggiani, D. Festi, V. Feletti, GM. Prati, E. Accogli, S. Casanova, M. Derenzini, E. Roda, and G. Mazzella

Subjects
HEPATOCELLULAR CARCINOMA, PROLIFERATION, HCV, STATISTICAL MODEL, CIRRHOSIS
Published
2005

181. Genetic polymorphisms of PPAR-alpha: allele frequency in gallstone patients

Author

MONTAGNANI, MARCO, ALDINI, RITA, BACCHI REGGIANI, MARIA LETIZIA, FESTI, DAVIDE, AZZAROLI, FRANCESCO, COLECCHIA, ANTONIO, MAZZELLA, GIUSEPPE, MINNI, FRANCESCO, RODA, ENRICO, E. Ravaioli, R. Righetti, M. Montagnani, E. Ravaioli, R. Aldini, R. Righetti, M.L. Bacchi-Reggiani, D. Festi, F. Azzaroli, A. Colecchia, G. Mazzella, F. Minni, and E. Roda.

Subjects
GALLSTONES, PPAR-ALPHA, GENETIC, POLYMORPHISMS
Published
2005

182. Pharmacological modulation of MRP2 in primary biliary cirrhosis

Author

AZZAROLI, FRANCESCO, COLECCHIA, ANTONIO, GUARDIGLI, MASSIMO, RODA, ALDO, CASANOVA, SILVIA, FELETTI, VALENTINA, LODATO, FRANCESCA, MONTAGNANI, MARCO, FESTI, DAVIDE, RODA, ENRICO, MAZZELLA, GIUSEPPE, M. Marangi, F. Azzaroli, A. Colecchia, M. Guardigli, A. Roda, M. Marangi, S. Casanova, V. Feletti, F. Lodato, M. Montagnani, D. Festi, E. Roda, and G. Mazzella

Subjects
MRP2, PRIMARY BILIARY CIRRHOSIS, TREATMENT
Published
2005

183. Prevalence of different PPAR-alpha gene polymorphisms and haplotypes in gallstone patients. Dig Liv Dis 2005;Vol. 37 Suppl.1:S36

Author

MONTAGNANI, MARCO, ALDINI, RITA, BACCHI REGGIANI, MARIA LETIZIA, FESTI, DAVIDE, AZZAROLI, FRANCESCO, MAZZELLA, GIUSEPPE, MINNI, FRANCESCO, RODA, ENRICO, E. Ravaioli, A. Morganti, M. Montagnani, E. Ravaioli, R. Aldini, M.L. Bacchi-Reggiani, D. Festi, F. Azzaroli, G. Mazzella, A. Morganti, F. Minni, and E. Roda

Subjects
PPARA, POLYMORPHISM, GALLSTONE
Abstract

The nuclear receptor PPAR-alpha (Peroxisome proliferator-activated receptor-alpha) regulates the transcription of genes involved in fatty acid and bile acid metabolism and transport. PPAR-alpha is activated following binding with natural (fatty acids) or exogenous (fibrates) ligands. A common polymorphism in the PPAR-alpha gene (PPARA) is a functional missense mutation which causes a leucine to valine substitution (L162V). Another frequent polymorphism is a G to C transversion in intron 7. In order to test the etiopathogenic relevance of PPARA polymorphisms in gallstone disease, we investigated the prevalence of exon 5 and intron 7 variants, either isolated or in combination, in gallstone patients and in a control population. One hundred and twenty seven gallstone patients (56 males, 71 females) admitted to the hospital for either elective cholecystectomy or endoscopic treatment of choledocolithiasis, were screened for the presence of PPARA polymorphisms. Control population was composed of 110 age matched hospital workers and university students (53 males, 57 females). After DNA extraction from peripheral blood leukocytes, PCR amplification of exon 5 and intron 7 was performed. Denaturing-high performance liquid chromatography (D-HPLC) was then used to screen the PCR products for the presence of polymorphisms. Automated sequencing was employed to confirm and characterize the polymorphisms. Statistical analysis was performed by the chi-square test. The overall carrier frequency of exon 5 L162V polymorphism was 11% in the control population and 13.4% in the gallstone group (p=NS). The total carrier frequency for intron 7 polymorphism was 25% in the control population, while in male and female lithiasic patients it was 43% and 37%, respectively (p= 0.03). The haplotype characterized by exon 5 L162V, in the absence of intron 7 polymorphism, was not found in males with gallstones, while a 11% frequency was observed in male controls (p=0.02). These data demonstrate a significant higher prevalence of PPARA intron 7 polymorphism in gallstone patients, mainly due to its frequency in the male subgroup. Furthermore, the haplotype characterized by exon 5 L162V, in the absence of an associated intron 7 polymorphism, seems to confer protection from gallstones in males but not in females, supporting an hormone modulation on PPAR-alpha polymorphic variants.

Published
2005

185. Infezioni, infestazioni, patologia gastroenterologica emergente dall’immigrazione (capitolo 56)

Author

FESTI, DAVIDE, MONTAGNANI, MARCO, COORDINAMENTO DOCENTI UNIVERSITARI MALATTIE DELLAPPARATO DIGERENTE, D.Festi, and M.Montagnani

Subjects
INFEZIONI, INFESTAZIONI, DIARREA, PARASSITOSI
Abstract

Il capitolo approfondisce i seguenti argomenti: -impatto dei fenomeni migratori sulla diffusione delle infezioni ed infestazioni a carico dell'apparato digerente; -cause di infezioni ed infestazioni gastrointestinali; - principali sintomi clinici delle infezioni ed infestazioni gastrointestinali; -strumenti diagnostici utili per la diagnosi di infezione ed infestazione gastrointestinale -indirizzi terapeutici nei confronti delle principali infezioni ed infestazioni gastrointestinali. dei fenomeni migratori sulla diffusione delle infezioni ed infestazioni

Published
2004

186. Safety of interferon beta treatment for chronic HCV hepatitis

Author

FESTI, DAVIDE, MAZZELLA, GIUSEPPE, RODA, ENRICO, VESTITO, AMANDA, COLECCHIA, ANTONIO, SANDRI L, SACCO T, STANISCIA T, CAPODICASA S, FESTI D., SANDRI L, MAZZELLA G, RODA E, SACCO T, STANISCIA T, CAPODICASA S, VESTITO A, and COLECCHIA A.

Published
2004

188. Italian consensus conference for colonic diverticulosis and diverticular disease

Author

Cuomo, Rosario, primary, Barbara, Giovanni, additional, Pace, Fabio, additional, Annese, Vito, additional, Bassotti, Gabrio, additional, Binda, Gian Andrea, additional, Casetti, Tino, additional, Colecchia, Antonio, additional, Festi, Davide, additional, Fiocca, Roberto, additional, Laghi, Andrea, additional, Maconi, Giovanni, additional, Nascimbeni, Riccardo, additional, Scarpignato, Carmelo, additional, Villanacci, Vincenzo, additional, and Annibale, Bruno, additional

Published
2014
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189. Spleen stiffness measurement can predict clinical complications in compensated HCV-related cirrhosis: A prospective study

Author

Colecchia, Antonio, primary, Colli, Agostino, additional, Casazza, Giovanni, additional, Mandolesi, Daniele, additional, Schiumerini, Ramona, additional, Reggiani, Letizia Bacchi, additional, Marasco, Giovanni, additional, Taddia, Martina, additional, Lisotti, Andrea, additional, Mazzella, Giuseppe, additional, Di Biase, Anna Rita, additional, Golfieri, Rita, additional, Pinzani, Massimo, additional, and Festi, Davide, additional

Published
2014
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190. Gut microbiota and metabolic syndrome

Author

Festi, Davide, primary, Schiumerini, Ramona, additional, Eusebi, Leonardo Henry, additional, Marasco, Giovanni, additional, Taddia, Martina, additional, and Colecchia, Antonio, additional

Published
2014
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191. Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation

Author

Masetti, R, Zama, D, Gasperini, P, Morello, W, Prete, A, Colecchia, A, Festi, D, Pession, A, Masetti, Riccardo, Zama, Daniele, Gasperini, Pietro, Morello, William, Prete, Arcangelo, Colecchia, Antonio, Festi, Davide, Pession, Andrea, Masetti, R, Zama, D, Gasperini, P, Morello, W, Prete, A, Colecchia, A, Festi, D, Pession, A, Masetti, Riccardo, Zama, Daniele, Gasperini, Pietro, Morello, William, Prete, Arcangelo, Colecchia, Antonio, Festi, Davide, and Pession, Andrea

Abstract

FNH is a non-malignant neoplasia of the liver rarely described in children. A significant percentage of the pediatric cases have been reported in patients with a history of malignant disease treated with chemo-radiation therapy and in children who were given HSCT. Little is known about the pathogenesis of FNH in transplanted children, but many risk factors linked to the HSCT procedure have been hypothesized. The detection of hepatic nodules, particularly in children who underwent HSCT for a previous malignancy, always raises a diagnostic dilemma. To help the physicians in the diagnostic management of this rare entity, we have retrospectively evaluated a series of transplanted children diagnosed with FNH in our Center over the last 15 yr. In this period, we found 10 new diagnoses of FNH. The diagnostic work-up included CEUS, abdominal CT, and MRI. A liver biopsy was performed in two patients. The median FUP time after diagnosing FNH was 3.8 yr, with an abdominal US and no malignant transformation were observed. Possible risk factors and indications for the management of FNH in transplanted children are reported and discussed in a comprehensive review of the literature. © 2013 John Wiley & Sons A/S.

Published
2013

192. Indocyanine green retention test as a noninvasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis

Author

Lisotti, Andrea, primary, Azzaroli, Francesco, additional, Buonfiglioli, Federica, additional, Montagnani, Marco, additional, Cecinato, Paolo, additional, Turco, Laura, additional, Calvanese, Claudio, additional, Simoni, Patrizia, additional, Guardigli, Massimo, additional, Arena, Rosario, additional, Cucchetti, Alessandro, additional, Colecchia, Antonio, additional, Festi, Davide, additional, Golfieri, Rita, additional, and Mazzella, Giuseppe, additional

Published
2013
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194. Reply

Author

Colecchia, Antonio, primary, Colli, Agostino, additional, and Festi, Davide, additional

Published
2012
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197. Indocyanine Green as a Predictor of Clinically Significant Portal Hypertension in a Prospective Cohort Study of Patients With Chronic Liver Disease

Author

Lisotti, Andrea, primary, Azzaroli, Francesco, additional, Turco, Laura, additional, Buonfiglioli, Federica, additional, Cecinato, Paolo, additional, Calvanese, Claudio, additional, Lodato, Francesca, additional, Montagnani, Marco, additional, Golfieri, Rita, additional, Colecchia, Antonio, additional, Festi, Davide, additional, and Mazzella, Giuseppe, additional

Published
2011
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198. Indocyanine Green Clearance as a Marker of Decompensation and Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis

Author

Turco, Laura, primary, Azzaroli, Francesco, additional, Buonfiglioli, Federica, additional, Lisotti, Andrea, additional, Cecinato, Paolo, additional, Calvanese, Claudio, additional, Lodato, Francesca, additional, Montagnani, Marco, additional, Golfieri, Rita, additional, Colecchia, Antonio, additional, Festi, Davide, additional, and Mazzella, Giuseppe, additional

Published
2011
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