599 results on '"Fernández-Barral, A."'
Search Results
152. Monitoring of the radio galaxy M 87 during a low-emission state from 2012 to 2015 with MAGIC
- Author
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Acciari, V A, Ansoldi, Antonelli, S, L A, Arbet , Engels, Arcaro, A, Baack, C, Babić, D, Banerjee, A, Bangale, B, Barres , de , Almeida, P, Barrio, U, J A, Becerra , González, Bednarek, J, Bellizzi, W, Bernardini, L, Berti, E, Besenrieder, A, Bhattacharyya, J, Bigongiari, W, Biland, C, Blanch, A, Bonnoli, O, Bošnjak, G, Busetto, Ž, Carosi, G, Ceribella, R, Chai, G, Chilingaryan, Y, Cikota, A, Colak, S, S M, Colin, Colombo, U, Contreras, E, J L, Cortina, Covino, J, D’Elia, S, Da , Vela, V, Dazzi, P, De , Angelis, F, Lotto, A, Delfino, B, Delgado, M, Depaoli, J, Di , Pierro, D, Venere, F, Do , Souto , Espiñeira, L, Dominis , Prester, E, Donini, D, Dorner, A, Doro, D, Elsaesser, M, Fallah , Ramazani, D, Fattorini, V, Fernández-Barral, A, Ferrara, A, Fidalgo, G, Foffano, D, Fonseca, L, M V, Font, Fruck, L, Fukami, C, García , López, S, R J, Garczarczyk, Gasparyan, M, Gaug, S, Giglietto, M, Giordano, N, Godinović, F, Green, N, Guberman, D, Hadasch, D, Hahn, D, Herrera, A, Hoang, J, Hrupec, J, Hütten, D, Inada, M, Inoue, T, Ishio, S, Iwamura, K, Jouvin, Y, Kerszberg, L, Kubo, D, Kushida, H, Lamastra, J, Lelas, A, D, Leone, F., Lindfors, E., Lombardi, Longo, S, López, F, López-Coto, M, López-Oramas, R, Loporchio, A, Machado , Oliveira , Fraga, S, Maggio, B, Majumdar, C, Makariev, P, Mallamaci, M, Maneva, M, Manganaro, G, Mannheim, M, Maraschi, K, Mariotti, L, Martínez, M, Masuda, M, Mazin, S, Mićanović, D, Miceli, S, Minev, D, Miranda, M, J M, Mirzoyan, Molina, R, Moralejo, E, Morcuende, A, Moreno, D, Moretti, V, Munar-Adrover, E, Neustroev, P, Nigro, V, Nilsson, C, Ninci, K, Nishijima, D, Noda, K, Nogués, K, Nöthe, L, Nozaki, M, Paiano, S, Palacio, S, Palatiello, J, Paneque, M, Paoletti, D, Paredes, R, Peñil, Peresano, P, Persic, M, Prada , Moroni, M, P G, Prandini, Puljak, E, Rhode, I, Ribó, W, Rico, M, Righi, J, Rugliancich, C, Saha, A, Sahakyan, L, Saito, N, Sakurai, T, Satalecka, S, Schmidt, K, Schweizer, K, Sitarek, T, Šnidarić, J, Sobczynska, I, Somero, D, Stamerra, A, Strom, A, Strzys, D, Suda, M, Surić, Y, Takahashi, T, Tavecchio, M, Temnikov, F, Terzić, P, Teshima, T, Torres-Albà, M, Tosti, N, Tsujimoto, L, Vagelli, S, van , Scherpenberg, V, Vanzo, J, Acosta, G, M Vazquez, Vigorito, C F, Vitale, Vovk, V, Will, I, Zarić, M, Asano, D, Collaborators: K, Hada, Harris, K, D E, Giroletti, Jermak, M, H E, Madrid, J P, Massaro, Richter, F, Spanier, S, Steele, F, I A, Walker, R, C, European Space Agency, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), National Aeronautics and Space Administration (US), Agencia Estatal de Investigación (España), European Commission, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Arcaro, C., Baack, D., Babic, A., Banerjee, B., Bangale, P., Barres de Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., da Vela, P., Dazzi, F., de Angelis, A., de Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Tsujimoto, S., Vagelli, V., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., Asano, K., Hada, K., Harris, D. E., Giroletti, M., Jermak, H. E., Madrid, J. P., Massaro, F., Richter, S., Spanier, F., Steele, I. A., Walker, R. C., 30588766 - Arcaro, Cornelia, 25433822 - Richter, Stephan, and 25161814 - Spanier, Felix Alexander
- Subjects
galaxies [Gamma rays] ,Photon ,Radio galaxy ,VHE [gamma ray] ,radiation mechanisms non-thermal ,galaxies active ,galaxies individual M 87 ,galaxies jets ,gamma rays galaxies ,magnetic field ,Astrophysics ,jet [Galaxies] ,01 natural sciences ,Power law ,law.invention ,galaxies: individual: M 87 ,law ,flux [gamma ray] ,radiation mechanisms: non-thermal ,galaxies: active ,galaxies: jets ,gamma rays: galaxies ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics ,QC ,QB ,High Energy Astrophysical Phenomena (astro-ph.HE) ,astro-ph.HE ,Physics ,galaxie [Gamma rays] ,photon ,Synchrotron ,Magnetic field ,Wavelength ,Galaxies: active ,Galaxies: individual: M 87 ,Galaxies: jets ,Gamma rays: galaxies ,Radiation mechanisms: non-thermal ,Spectral energy distribution ,Astrophysics and Astronomy ,active [Galaxies] ,Astrophysics::High Energy Astrophysical Phenomena ,radio wave [galaxy] ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,GLAST ,GeneralLiterature_MISCELLANEOUS ,Telescope ,emission [gamma ray] ,synchrotron ,0103 physical sciences ,Astrophysics::Galaxy Astrophysics ,non-thermal [Radiation mechanisms] ,hybrid ,010308 nuclear & particles physics ,ComputingMilieux_PERSONALCOMPUTING ,individual: M 87 [galaxies] ,Astronomy and Astrophysics ,MAGIC ,monitoring ,Space and Planetary Science ,ddc:520 ,spectral ,jets [Galaxies] ,individual: M 87 [Galaxies] ,non-thermal [adiation mechanisms] - Abstract
MAGIC Collaboration: et al., M 87 is one of the closest (z = 0.004 36) extragalactic sources emitting at very high energies (VHE, E > 100 GeV). The aim of this work is to locate the region of the VHE gamma-ray emission and to describe the observed broad-band spectral energy distribution (SED) during the low VHE gamma-ray state. The data from M 87 collected between 2012 and 2015 as part of a MAGIC monitoring programme are analysed and combined with multiwavelength data from Fermi-LAT, Chandra, HST, EVN, VLBA, and the Liverpool Telescope. The averaged VHE gamma-ray spectrum can be fitted from ∼100 GeV to ∼10 TeV with a simple power law with a photon index of (−2.41 ± 0.07), while the integral flux above 300 GeV is (1.44±0.13)×10−12cm−2s−1. During the campaign between 2012 and 2015, M 87 is generally found in a low-emission state at all observed wavelengths. The VHE gamma-ray flux from the present 2012–2015M 87 campaign is consistent with a constant flux with some hint of variability (∼3σ) on a daily time-scale in 2013. The low-state gamma-ray emission likely originates from the same region as the flare-state emission. Given the broad-band SED, both a leptonic synchrotron self-Compton and a hybrid photohadronic model reproduce the available data well, even if the latter is preferred. We note, however, that the energy stored in the magnetic field in the leptonic scenario is very low, suggesting a matter-dominated emission region., The financial support of the German BMBF and MPG, the Italian Istituto Nazionale di Fisica Nucleare (INFN) and Istituto Nazionale di Astrofisica (INAF), the Swiss National Fund (SNF), the ERDF under the Spanish Ministry of Economy and Competitiveness (MINECO) (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, and the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia ‘Severo Ochoa’ SEV-2016-0588 and SEV2015-0548, and Unidad de Excelencia ‘Maria de Maeztu’ MDM2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers grants SFB823/C4 and SFB876/C3, by the Polish National Research Centre grant UMO2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq, and FAPERJ. The Very Long Baseline Array is operated by the National Radio Astronomy Observatory, which is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. The work of FM is supported by the ‘Departments of Excellence 2018–2022’ Grant awarded by the Italian Ministry of Education, University and Research (MIUR) (L. 232/2016). His research has made also use of resources provided by the Compagnia di San Paolo for the grant awarded on the BLENV project (S1618 L1 MASF 01) and by the Ministry of Education, Universities and Research for the grant MASF FFABR 17 01. This investigation is supported by the National Aeronautics and Space Administration (NASA) grants GO4-15096X, AR6-17012X, and GO6-17081X. This work made use of the Swinburne University of Technology software correlator, developed as part of the Australian Major National Research Facilities Programme and operated under licence. Based in part on observations made with the NASA/European Space Agency (ESA) Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. These observations are associated with programmes GO 12293, 12671, 13061, and 13759.
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- 2020
153. MAGIC observations of the diffuse γ -ray emission in the vicinity of the Galactic center
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U. Barres de Almeida, L. Nogués, Damir Lelas, Dorota Sobczyńska, Daniel Kerszberg, Zeljka Bosnjak, Satoshi Masuda, L. Maraschi, Elina Lindfors, M. Peresano, B. Banerjee, D. Strom, A. Rugliancich, Marina Manganaro, D. Zarić, Daniel Mazin, D. Dominis Prester, Shunsuke Sakurai, Kyoshi Nishijima, D. Fidalgo, Marc Ribó, I. Snidaric, S. Paiano, Pratik Majumdar, M. V. Fonseca, Giacomo Bonnoli, Martin Will, Karl Mannheim, Ivica Puljak, Seiya Nozaki, Juan Abel Barrio, M. Nöthe, Narek Sahakyan, Toshiaki Inada, Hidetoshi Kubo, G. Busetto, Konstancja Satalecka, Michele Doro, E. Molina, Pablo Peñil, P. Munar-Adrover, E. Colombo, Saša Mićanović, John Hoang, V. Fallah Ramazani, Lab Saha, T. Schweizer, Luca Foffano, K. Noda, Daniel Morcuende, Jose Luis Contreras, M. Palatiello, V. Vitale, J. Becerra González, Juan Cortina, Stefano Covino, Francesco Dazzi, A. Fernández-Barral, Alice Donini, L. A. Antonelli, D. Ninci, Sanae Inoue, U. Colin, Manuela Mallamaci, D. Hadasch, Alessio Berti, Kai Phillip Schmidt, Sidika Merve Colak, David A. Green, Alexander Hahn, Wrijupan Bhattacharyya, Jordi Delgado, Tomoki Saito, Giovanni Ceribella, J. van Scherpenberg, A. Arbet Engels, Léa Jouvin, Sargis Gasparyan, Fabrizio Tavecchio, A. Somero, F. Di Pierro, Lluis Font, Stefano Ansoldi, Manuel Delfino, I. Vovk, B. Machado de Oliveira Fraga, Vitaly Neustroev, Davide Depaoli, Riccardo Paoletti, Wolfgang Rhode, M. Strzys, David Paneque, D. Miceli, Mosè Mariotti, Yuki Iwamura, A. López-Oramas, P. G. Prada Moroni, N. Giglietto, Valerio Vagelli, Chiara Righi, G. Ferrara, J. Palacio, D. Guberman, Ana Babić, Nikola Godinovic, Luca Tosti, Ferdinando Giordano, P. Temnikov, Alicia Fattorini, R. J. García López, J. M. Paredes, Antonio Stamerra, Junko Kushida, P. Da Vela, M. I. Martínez, Serena Loporchio, Satoshi Fukami, G. Maneva, Jürgen Besenrieder, Christian Fruck, Camilla Maggio, Daniela Dorner, D. Elsaesser, Gaia Vanzo, V. A. Acciari, Massimo Persic, F. Leone, V. D'Elia, Kari Nilsson, M. Gaug, Adrian Biland, Masahiro Teshima, Saverio Lombardi, J. Herrera, Julian Sitarek, Cosimo Nigro, Elisa Bernardini, J. Rico, Dario Hrupec, M. A. Lopez, Mitsunari Takahashi, A. Chilingaryan, Dominik Baack, E. Do Souto Espiñeira, Tomislav Terzić, A. De Angelis, Yusuke Suda, Carlo Vigorito, Moritz Hütten, Abelardo Moralejo, E. Moretti, M. Minev, B. De Lotto, Ciro Bigongiari, M. Garczarczyk, R. López-Coto, Kazuma Ishio, Elisa Prandini, Rodolfo Carosi, R. Mirzoyan, Yating Chai, Stefan Cikota, M. Vazquez Acosta, Victoria Moreno, Francesco Longo, Lorenzo Bellizzi, Martin Makariev, Oscar Blanch, T. Surić, Shimpei Tsujimoto, Wlodek Bednarek, N. Torres-Albà, Jose Miguel Miranda, Alessandra Lamastra, L. Di Venere, Federal Ministry of Education and Research (Germany), Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), Japan Society for the Promotion of Science, Ministry of Education, Youth and Science (Bulgaria), Academy of Finland, Universidad de Barcelona, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Ministério da Ciência e Tecnologia (Brasil), Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Tsujimoto, S., Vagelli, V., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., and Zaric, D.
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model [background] ,accelerator ,Point source ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma rays: general ,background: model ,general [Gamma rays] ,Cosmic ray ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,programming ,01 natural sciences ,Spectral line ,law.invention ,energy: threshold ,law ,gas ,TRACER ,0103 physical sciences ,ISM [Gamma rays] ,010306 general physics ,010303 astronomy & astrophysics ,Cosmic rays ,Zenith ,Astrophysics::Galaxy Astrophysics ,Physics ,Gamma rays: ISM ,Galaxy: center ,Galactic ridge ,Galactic Center ,Astronomy and Astrophysics ,Particle accelerator ,center [Galaxy] ,threshold [energy] ,MAGIC ,gamma ray ,Space and Planetary Science ,cosmic radiation: galaxy ,ddc:520 ,galaxy [cosmic radiation] ,Física nuclear ,gamma rays: general ,gamma rays: ISM ,cosmic rays ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
[Aims] In the presence of a sufficient amount of target material, γ-rays can be used as a tracer in the search for sources of Galactic cosmic rays (CRs). Here we present deep observations of the Galactic center (GC) region with the MAGIC telescopes and use them to infer the underlying CR distribution and to study the alleged PeV proton accelerator at the center of our Galaxy., [Methods] We used data from ≈100 h observations of the GC region conducted with the MAGIC telescopes over five years (from 2012 to 2017). Those were collected at high zenith angles (58−70 deg), leading to a larger energy threshold, but also an increased effective collection area compared to low zenith observations. Using recently developed software tools, we derived the instrument response and background models required for extracting the diffuse emission in the region. We used existing measurements of the gas distribution in the GC region to derive the underlying distribution of CRs. We present a discussion of the associated biases and limitations of such an approach., [Results] We obtain a significant detection for all four model components used to fit our data (Sgr A*, “Arc”, G0.9+0.1, and an extended component for the Galactic Ridge). We observe no significant difference between the γ-ray spectra of the immediate GC surroundings, which we model as a point source (Sgr A*) and the Galactic Ridge. The latter can be described as a power-law with index 2 and an exponential cut-off at around 20 TeV with the significance of the cut-off being only 2σ. The derived cosmic-ray profile hints to a peak at the GC position and with a measured profile index of 1.2 ± 0.3 is consistent with the 1/r radial distance scaling law, which supports the hypothesis of a CR accelerator at the GC. We argue that the measurements of this profile are presently limited by our knowledge of the gas distribution in the GC vicinity., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Center grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ.
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- 2020
154. Plocabulin displays strong cytotoxic activity in a personalized colon cancer patient-derived 3D organoid assay
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Bustamante-Madrid, Pilar, Costales-Carrera, Alba, Fernández-Barral, A., Guerra, L., Barbáchano, Antonio, and Muñoz Terol, Alberto
- Abstract
Trabajo presentado en el III CIBERONC Young Researchers Meeting, celebrado en modalidad virtual el 14 de diciembre de 2020.
- Published
- 2020
155. Study of the variable broadband emission of Markarian 501 during the most extreme Swift X-ray activity
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Francesco Longo, Yuki Iwamura, Susumu Inoue, L. Nogués, M. I. Martínez, G. Pedaletti, Thomas Bretz, J. Buss, A. Rugliancich, Marina Manganaro, D. Galindo, Merja Tornikoski, Sabrina Einecke, Martin Makariev, Oscar Blanch, C. Leto, Ciro Bigongiari, Adrian Biland, D. Zarić, Andrii Neronov, M. Garczarczyk, Sargis Gasparyan, Konstancja Satalecka, Michele Doro, Marc Ribó, M. Noethe, J. Becerra González, Kazuma Ishio, J. Rico, Christian Fruck, Kyoshi Nishijima, Abelardo Moralejo, E. Moretti, Wolfgang Rhode, Christoph Wendel, Dominik Baack, Satoshi Masuda, Hidetoshi Kubo, Nikola Godinovic, B. Machado de Oliveira Fraga, Alexander Hahn, Manuel Delfino, Daniela Dorner, P. Giammaria, A. Niedzwiecki, Alessio Berti, U. Barres de Almeida, F. Verrecchia, G. Busetto, Lena Linhoff, D. Fidalgo, Damir Lelas, G. Ferrara, Alicia Fattorini, D. Hildebrand, David Paneque, V. A. Acciari, Bernd Schleicher, Gaia Vanzo, M. Peresano, Rodolfo Carosi, M. Perri, Alessandra Lamastra, John Hoang, Marcel Strzys, M. Gaug, Chiara Righi, M. Armas Padilla, D. Ninci, Ana Babić, Michael Blank, Dorota Sobczyńska, D. Dominis Prester, A. De Angelis, Vitaly Neustroev, I. Snidaric, F. Schulz, E. von Willert, D. Guberman, A. Y. Lien, J. Herrera, Juan Abel Barrio, B. Banerjee, J. van Scherpenberg, V. D'Elia, Narek Sahakyan, P. Temnikov, Stefano Ansoldi, R. J. García López, G. Maneva, E. Do Souto Espiñera, B. De Lotto, Elisa Bernardini, Riccardo Paoletti, S. Paiano, Karl Mannheim, Pablo Peñil, A. Shukla, Ivica Puljak, Jose Luis Contreras, D. Neise, Andrea Tramacere, Manuela Mallamaci, A. López-Oramas, Jordi Delgado, V. Fallah Ramazani, Juan Cortina, J. Palacio, P. Colin, R. Walter, J. M. Paredes, F. Di Pierro, Antonio Stamerra, Pratik Majumdar, Camilla Maggio, M. V. Fonseca, Ievgen Vovk, Francesco Dazzi, A. Fernández-Barral, Cosimo Nigro, P. Munar-Adrover, Massimo Persic, Dario Hrupec, L. A. Antonelli, Martin Will, D. Kuveždić, T. Schweizer, F. Leone, Anne Lähteenmäki, Tarek M. Hassan, Fabrizio Tavecchio, Masahiro Teshima, A. Somero, Kari Nilsson, Ll. Font, M. Bulinski, Wlodek Bednarek, Vitalii Sliusar, P. G. Prada Moroni, Junko Kushida, P. Da Vela, E. Prandini, N. Torres-Albà, Joni Tammi, Sebastian Achim Mueller, J. R. Garcia, Giacomo Bonnoli, Manuel Doerr, Stefano Gallozzi, Jose Miguel Miranda, Wrijupan Bhattacharyya, Julian Sitarek, T. Surić, Shimpei Tsujimoto, K. Bruegge, D. Elsaesser, Tomislav Terzić, Jürgen Besenrieder, E. Molina, E. Colombo, Lab Saha, Luca Foffano, Mosè Mariotti, A. Paravac, Saverio Lombardi, M. Nievas Rosillo, M. Minev, M. Balbo, D. Hadasch, R. Mirzoyan, A. Arbet-Engels, K. Sedlaczek, L. Maraschi, Elina Lindfors, Daniel Mazin, Stefan Cikota, M. Vazquez Acosta, Victoria Moreno, Stefano Covino, Tomoki Saito, Giovanni Ceribella, Aaron Dominguez, K. Noda, Sidika Merve Colak, M. López, German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Ministério da Ciência, Tecnologia e Inovação (Brasil), National Aeronautics and Space Administration (US), Department of Energy (US), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), Centre National de la Recherche Scientifique (France), Institut National de Physique Nucléaire et de Physique des Particules (France), Agenzia Spaziale Italiana, High Energy Accelerator Research Organization (Japan), Japan Aerospace Exploration Agency, Knut and Alice Wallenberg Foundation, Swedish Research Council, Swedish National Space Board, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Blanch, O., Bonnoli, G., Busetto, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., DI Pierro, F., Do Souto Espinera, E., Dominguez, A., Dominis Prester, D., Doro, M., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giammaria, P., Godinovic, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuvecdic, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Oramas, A., MacHado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Suric, T., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., Zaric, D., Arbet-Engels, A., Baack, D., Balbo, M., Biland, A., Blank, M., Bretz, T., Bruegge, K., Bulinski, M., Buss, J., Doerr, M., Dorner, D., Einecke, S., Elsaesser, D., Hildebrand, D., Linhoff, L., Mannheim, K., Mueller, S., Neise, D., Neronov, A., Noethe, M., Paravac, A., Rhode, W., Schleicher, B., Schulz, F., Sedlaczek, K., Shukla, A., Sliusar, V., Von Willert, E., Walter, R., Wendel, C., Tramacere, A., Lien, A., Perri, M., Verrecchia, F., Armas Padilla, M., Leto, C., Lahteenmaki, A., Tornikoski, M., Tammi, J., Department of Electronics and Nanoengineering, Metsähovi Radio Observatory, Aalto-yliopisto, and Aalto University
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galaxies: active ,BL Lacertae objects: individual: Mrk 501 ,gamma rays: galaxies ,X-rays: galaxies ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Flux ,Context (language use) ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,01 natural sciences ,Power law ,Spectral line ,Galaxies: active ,Gamma rays: galaxies ,individual: Mrk 501 [BL Lacertae objects] ,0103 physical sciences ,MAGIC (telescope) ,Blazar ,010303 astronomy & astrophysics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,galaxie [Gamma rays] ,010308 nuclear & particles physics ,Gamma ray ,Astronomy and Astrophysics ,galaxies [X-rays] ,Crab Nebula ,Space and Planetary Science ,active [galaxies] ,galaxies [gamma rays] ,ddc:520 ,Física nuclear ,High Energy Astrophysical Phenomena ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
[Context] Markarian 501 (Mrk 501) is a very high-energy (VHE) gamma-ray blazar located at z = 0:034, which is regularly monitored by a wide range of multi-wavelength instruments, from radio to VHE gamma rays. During a period of almost two weeks in July 2014, the highest X-ray activity of Mrk 501 was observed in -14 years of operation of the Neil Gehrels Swift Gamma-ray Burst Observatory., [Aims] We characterize the broadband variability of Mrk 501 from radio to VHE gamma rays during the most extreme X-ray activity measured in the last 14 years, and evaluate whether it can be interpreted within theoretical scenarios widely used to explain the broadband emission from blazars., [Methods] The emission of Mrk 501 was measured at radio with Metsähovi, at optical–UV with KVA and Swift/UVOT, at X-ray with Swift/XRT and Swift/BAT, at gamma ray with Fermi-LAT, and at VHE gamma rays with the FACT and MAGIC telescopes. The multi-band variability and correlations were quantified, and the broadband spectral energy distributions (SEDs) were compared with predictions from theoretical models., [Results] The VHE emission of Mrk 501 was found to be elevated during the X-ray outburst, with a gamma-ray flux above 0.15 TeV varying from ∼0.5 to ∼2 times the Crab nebula flux. The X-ray and VHE emission both varied on timescales of 1 day and were found to be correlated. We measured a general increase in the fractional variability with energy, with the VHE variability being twice as large as the X-ray variability. The temporal evolution of the most prominent and variable segments of the SED, characterized on a day-by-day basis from 2014 July 16 to 2014 July 31, is described with a one-zone synchrotron self-Compton model with variations in the break energy of the electron energy distribution (EED), and with some adjustments in the magnetic field strength and spectral shape of the EED. These results suggest that the main flux variations during this extreme X-ray outburst are produced by the acceleration and the cooling of the high-energy electrons. A narrow feature at ∼3 TeV was observed in the VHE spectrum measured on 2014 July 19 (MJD 56857.98), which is the day with the highest X-ray flux (>0.3 keV) measured during the entire Swift mission. This feature is inconsistent with the classical analytic functions to describe the measured VHE spectra (power law, log-parabola, and log-parabola with exponential cutoff) at more than 3σ. A fit with a log-parabola plus a narrow component is preferred over the fit with a single log-parabola at more than 4σ, and a dedicated Monte Carlo simulation estimated the significance of this extra component to be larger than 3σ. Under the assumption that this VHE spectral feature is real, we show that it can be reproduced with three distinct theoretical scenarios: (a) a pileup in the EED due to stochastic acceleration; (b) a structured jet with two-SSC emitting regions, with one region dominated by an extremely narrow EED; and (c) an emission from an IC pair cascade induced by electrons accelerated in a magnetospheric vacuum gap, in addition to the SSC emission from a more conventional region along the jet of Mrk 501., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ. The Fermi-LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat à l’Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucléaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Instituto Nazionale di Astrofisica in Italy and the Centre National d’Études Spatiales in France. The important contributions from ETH Zurich grants ETH-10.08-2 and ETH-27.12-1 as well as the funding by the Swiss SNF and the German BMBF (Ver-bundforschung Astro-und Astroteilchenphysik) and HAP (Helmoltz Alliance for Astroparticle Physics) are gratefully acknowledged. Part of this work is supported by Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center SFB 876, project C3. We thank the Instituto de Astrofisica de Canarias for allowing us to operate the telescope at the Observatorio del Roque de los Muchachos in La Palma, the Max-Planck-Institut fur Physik for providing us with the mount of the former HEGRA CT3 telescope, and the MAGIC Collaboration for their support. JBG acknowledges the support of the Viera y Clavijo program funded by ACIISI and ULL. C. W. is grateful for the support by the project “Promotion inklusive” of the Universität zu Köln and the German Bundesmin-isterium für Arbeit und Soziales. This publication makes use of data obtained at Metsähovi Radio Observatory, operated by Aalto University, Finland.
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- 2020
156. The Great Markarian 421 Flare of 2010 February: Multiwavelength Variability and Correlation Studies
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Abeysekara, A. U., Benbow, W., Bird, R., Brill, A., Brose, R., Buchovecky, M., Buckley, J. H., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Dumm, J., Falcone, A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Galante, N., Gent, A., Gillanders, G. H., Giuri, C., Gueta, O., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Moriarty, P., Mukherjee, R., Nelson, T., Nieto, D., Nievas-Rosillo, M., O’Brien, S., Ong, R. A., Otte, A. N., Park, N., Petrashyk, A., Pichel, A., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rovero, A. C., Rulten, C., Sadeh, I., Santander, M., Sembroski, G. H., Shahinyan, K., Stevenson, B., Sushch, I., Tyler, J., Vassiliev, V. V., Wakely, S. P., Weinstein, A., Wells, R. M., Wilcox, P., Wilhelm, A., Williams, D. A., Zitzer, B., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babić, A., Banerjee, B., Barres de Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D’Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Do Souto Espiñera, E., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Godinović, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nöthe, M., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Sun, S., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., Zarić, D., Aller, H. D., Aller, M. F., Carini, M. T., Horan, D., Jordan, B., Jorstad, S. G., Kurtanidze, O. M., Kurtanidze, S. O., Lähteenmäki, A., Larionov, V. M., Larionova, E. G., Madejski, G., Marscher, A. P., Max-Moerbeck, W., Moody, J. Ward, Morozova, D. A., Nikolashvili, M. G., Raiteri, C. M., Readhead, A. C. S., Richards, J. L., Sadun, A. C., Sakamoto, T., Sigua, L. A., Smith, P. S., Talvikki, H., Tammi, J., Tornikoski, M., Troitsky, I. S., Villata, M., (VERITAS Collaboration), (MAGIC Collaboration), (Multiwavelength Partners), Department of Energy (US), Smithsonian Institution, National Science Foundation (US), National Energy Research Scientific Computing Center (US), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, National Aeronautics and Space Administration (US), Shota Rustaveli National Science Foundation, Boston University, University of Utah, Harvard University, University of California Los Angeles, Columbia University, University of Potsdam, Washington University St. Louis, California Polytechnic State University, San Luis Obispo, Iowa State University, University of Minnesota Twin Cities, Pennsylvania State University, Purdue University, California State University, East Bay, Georgia Institute of Technology, National University of Ireland, Galway, German Electron Synchrotron, University of California Santa Cruz, University of Delaware, University of Iowa, DePauw University, McGill University, Complutense University, University College Dublin, University of Wisconsin-Madison, Universidad de Buenos Aires, Cork Institute of Technology, University of Alabama, University of Chicago, Instituto de Astrofísica de Canarias, University of Udine, INAF, Osservatorio Astronomico di Roma, Swiss Federal Institute of Technology Zurich, Dortmund University, Saha Institute of Nuclear Physics, Centro Brasileiro de Pesquisas Físicas, University of Łódź, University of Siena, National Institute for Nuclear Physics, Max Planck Institute for Physics, Institute for High Energy Physics, University of Padova, University of Pisa, University of Würzburg, University of Turku, Autonomous University of Barcelona, University of Barcelona, National Academy of Sciences of the Republic of Armenia, The University of Tokyo, Bulgarian Academy of Sciences, Fudan University, University of Michigan, Ann Arbor, Western Kentucky University, CNRS, Dublin Institute for Advanced Studies, Ilia State University, Department of Electronics and Nanoengineering, St. Petersburg State University, United States Department of Energy, Universidad de Chile, Brigham Young University, California Institute of Technology, University of Colorado Denver, Aoyama Gakuin University, University of Arizona, Metsähovi Radio Observatory, Aalto-yliopisto, Aalto University, Abeysekara, A. U., Benbow, W., Bird, R., Brill, A., Brose, R., Buchovecky, M., Buckley, J. H., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Dumm, J., Falcone, A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Galante, N., Gent, A., Gillanders, G. H., Giuri, C., Gueta, O., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Moriarty, P., Mukherjee, R., Nelson, T., Nieto, D., Nievas-Rosillo, M., O'Brien, S., Ong, R. A., Otte, A. N., Park, N., Petrashyk, A., Pichel, A., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rovero, A. C., Rulten, C., Sadeh, I., Santander, M., Sembroski, G. H., Shahinyan, K., Stevenson, B., Sushch, I., Tyler, J., Vassiliev, V. V., Wakely, S. P., Weinstein, A., Wells, R. M., Wilcox, P., Wilhelm, A., Williams, D. A., Zitzer, B., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Do Souto Espiñera, E., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Sun, S., Suric, T., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., Zaric, D., Aller, H. D., Aller, M. F., Carini, M. T., Horan, D., Jordan, B., Jorstad, S. G., Kurtanidze, O. M., Kurtanidze, S. O., Lahteenmaki, A., Larionov, V. M., Larionova, E. G., Madejski, G., Marscher, A. P., Max-Moerbeck, W., Moody, J. W., Morozova, D. A., Nikolashvili, M. G., Raiteri, C. M., Readhead, A. C. S., Richards, J. L., Sadun, A. C., Sakamoto, T., Sigua, L. A., Smith, P. S., Talvikki, H., Tammi, J., Tornikoski, M., Troitsky, I. S., and Villata, M.
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Multiple days ,Gamma-ray astronomY ,010504 meteorology & atmospheric sciences ,Astrophysics::High Energy Astrophysical Phenomena ,Flux ,Markarian galaxies ,Astrophysics ,Blazar ,01 natural sciences ,7. Clean energy ,BL Lacertae object ,High energy astrophysic ,law.invention ,law ,Observatory ,BL Lacertae objects ,Blazars ,High energy astrophysics ,Relativistic jets ,Gamma-ray astronomy ,Time domain astronomy ,Relativistic jet ,0103 physical sciences ,MAGIC (telescope) ,BL lacertae objects ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences ,Physics ,Astronomy and Astrophysics ,Light curve ,Space and Planetary Science ,Markarian galaxie ,Electrónica ,Electricidad ,Flare - Abstract
We report on variability and correlation studies using multiwavelength observations of the blazar Mrk 421 during the month of 2010 February, when an extraordinary flare reaching a level of ∼27 Crab Units above 1 TeV was measured in very high energy (VHE) γ-rays with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) observatory. This is the highest flux state for Mrk 421 ever observed in VHE γ-rays. Data are analyzed from a coordinated campaign across multiple instruments, including VHE γ-ray (VERITAS, Major Atmospheric Gamma-ray Imaging Cherenkov), high-energy γ-ray (Fermi-LAT), X-ray (Swift, Rossi X-ray Timing Experiment, MAXI), optical (including the GASP-WEBT collaboration and polarization data), and radio (Metsahovi, Owens Valley Radio Observatory, University of Michigan Radio Astronomy Observatory). Light curves are produced spanning multiple days before and after the peak of the VHE flare, including over several flare "decline" epochs. The main flare statistics allow 2 minute time bins to be constructed in both the VHE and optical bands enabling a cross-correlation analysis that shows evidence for an optical lag of ∼25-55 minutes, the first time-lagged correlation between these bands reported on such short timescales. Limits on the Doppler factor (δ ⪆ 33) and the size of the emission region (δR≲ 3.8 × 10cm) are obtained from the fast variability observed by VERITAS during the main flare. Analysis of 10 minute binned VHE and X-ray data over the decline epochs shows an extraordinary range of behavior in the flux-flux relationship, from linear to quadratic to lack of correlation to anticorrelation. Taken together, these detailed observations of an unprecedented flare seen in Mrk 421 are difficult to explain with the classic single-zone synchrotron self-Compton model., This research is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation, the Smithsonian Institution, and NSERC in Canada. This research used resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy’s Office of Science, and the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under contract No. DE-AC02- 05CH11231. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and the collaborating institutions in the construction and operation of the instrument. The MAGIC collaboration would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2- R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015- 71662-C2-2-P, FPA201790566REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, and the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV2015-0548 and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782, the University of Rijeka Project 13.12.1.3.02, the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382, and the Brazilian MCTIC, CNPq, and FAPERJ. This publication makes use of data obtained at Metsähovi Radio Observatory, operated by Aalto University, Finland, and the OVRO 40 m monitoring program, which is supported in part by NASA grants NNX08AW31G, NNX11A043G, and NNX14AQ89G and NSF grants AST-0808050 and AST1109911. The UMRAO data were obtained through NSF grant AST 0607523 and NASA Fermi GI award NNX09AU16G. The St. Petersburg University team acknowledges support from Russian RFBR foundation, grant 12-02-00452. The Abastumani Observatory team acknowledges financial support by the Shota Rustaveli National Science Foundation through project FR/577/6-320/13. The Steward Observatory data were obtained under Fermi Guest Investigator Program grant NNX09AU10G. The research at Boston University is supported by NASA grant 80NSSC17K0649 and NSF grant AST-1615796. Software. VEGAS (Cogan 2008), Event Display (Daniel 2008), MARS (Moralejo et al. 2009), Fermi Science Tools81, HEASoft (FTOOLS+XANADU; HEASARC 2014), REX,85 Xspec (Arnaud 1996), emcee (Foreman-Mackey et al. 2013).
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- 2020
157. Hypoxia negatively regulates antimetastatic PEDF in melanoma cells by a hypoxia inducible factor-independent, autophagy dependent mechanism.
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Asunción Fernández-Barral, José Luis Orgaz, Valentí Gomez, Luis del Peso, María José Calzada, and Benilde Jiménez
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Medicine ,Science - Abstract
Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor (SERPIN) superfamily, displays a potent antiangiogenic and antimetastatic activity in a broad range of tumor types. Melanocytes and low aggressive melanoma cells secrete high levels of PEDF, while its expression is lost in highly aggressive melanomas. PEDF efficiently abrogates a number of functional properties critical for the acquisition of metastatic ability by melanoma cells, such as neovascularization, proliferation, migration, invasiveness and extravasation. In this study, we identify hypoxia as a relevant negative regulator of PEDF in melanocytes and low aggressive melanoma cells. PEDF was regulated at the protein level. Importantly, although downregulation of PEDF was induced by inhibition of 2-oxoglutarate-dependent dioxygenases, it was independent of the hypoxia inducible factor (HIF), a key mediator of the adaptation to hypoxia. Decreased PEDF protein was not mediated by inhibition of translation through untranslated regions (UTRs) in melanoma cells. Degradation by metalloproteinases, implicated on PEDF degradation in retinal pigment epithelial cells, or by the proteasome, was also excluded as regulatory mechanism in melanoma cells. Instead, we found that degradation by autophagy was critical for PEDF downregulation under hypoxia in human melanoma cells. Our findings show that hypoxic conditions encountered during primary melanoma growth downregulate antiangiogenic and antimetastasic PEDF by a posttranslational mechanism involving degradation by autophagy and could therefore contribute to the acquisition of highly metastatic potential characteristic of aggressive melanoma cells.
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- 2012
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158. Comparative study of organoids from patient-derived normal and tumor colon and rectal tissue
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Fernández-Barral, Asunción, Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Domínguez, Orlando, Guerra-Pastrián, Laura, Peso, Luis del, Burgos, Aurora, Barbáchano, Antonio, Muñoz Terol, Alberto, Fernández-Barral, Asunción, Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Domínguez, Orlando, Guerra-Pastrián, Laura, Peso, Luis del, Burgos, Aurora, Barbáchano, Antonio, and Muñoz Terol, Alberto
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- 2020
159. Drug activity assays in CRC patient-derived organoids
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Fernández-Barral, Asunción and Fernández-Barral, Asunción
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- 2020
160. Targeting Colorectal Disease Through Patient-derived Colon Cancer Organoids
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Fernández-Barral, Asunción and Fernández-Barral, Asunción
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Hans Clevers’ group changed the rules of the game when they isolated and grew in vitro adult stem cells from normal and tumor intestinal tissue. These cells, embedded in an extracellular matrix that allows their growth in 3D, better reflect the genetic background, cellular heterogeneity, structure, and functionality of their tissue of origin. These structures derived from stem cells were called organoids and can be obtained from multiple organs of different species. Organoids constitute an alternative for animal models and 2D culture and are a promising tool for basic research, disease modelling, drug development, personalized treatments, and regenerative medicine. The Instituto de Investigaciones Biomedicas "Alberto Sols", CSIC-UAM has used 3D cell culture technology to create a unique living biobank of organoids from healthy and tumor colon tissue of over 90 colorectal cancer patients. Using this valuable material, we have studied the role of vitamin D in colon homeostasis and its protective action against colon cancer. Additionally, we have also developed a reproducible drug screening system in tumor colon organoids.
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- 2020
161. Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7−3946
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Csaba Balázs, M. Servillat, F. D'Ammando, D. Nosek, T. Yamamoto, A. Bilinsky, H.-S. Zechlin, Francesco Dazzi, A. Fernández-Barral, Satoshi Yoshiike, Catherine Boisson, Philippe Laporte, K. Nishijima, Yutaka Fujita, T. Armstrong, A. Shalchi, S. Kimura, D. Nakajima, Fuyuki Tokanai, Francesco Longo, S. Pavy, Philip Kaaret, W. van Driel, Gianpiero Tagliaferri, L. Nogués, F. Di Pierro, Wystan Benbow, T. Stolarczyk, Marco Padovani, T. Di Girolamo, Johan Bregeon, J. Rico, R. Wischnewski, A. Sillanpää, T. Grabarczyk, E. Pueschel, P. Blasi, S. D. Vergani, A. De Franco, C. Bonavolontà, J. Prast, J. Zorn, Elisabetta Bissaldi, Giuseppe Malaguti, A. Pe'Er, Stefano Covino, Akira Okumura, Takashi Saito, C. Aramo, Hermine Landt, R. Zanin, E. Fedorova, Shinji Hara, Yutaka Ohira, Petr Janecek, Petar Temnikov, T. B. Humensky, E. Fiandrini, C. Townsley, R. J. White, A. Fiasson, Koji Noda, Takanori Yoshikoshi, Y. Ikeno, Elena Amato, Yasuo Fukui, J. P. Lees, M. Nievas-Rosillo, Vito Conforti, Kazunori Kohri, I. Oya, M. Trifoglio, Gavin Rowell, Jacek Niemiec, Juan Abel Barrio, R. Walter, Stefan Wagner, Teresa Mineo, J. J. Watson, Reiko Orito, Masahiro Teshima, Jim Hinton, A. Pisarski, G. Rodriguez Fernandez, F. De Frondat, Robert Wagner, Pedro L. Luque-Escamilla, G. Morlino, Thomas Lohse, B. Rudak, Olaf Reimer, Josep Martí, Subir Sarkar, Martin White, Johann Cohen-Tanugi, Michiyuki Chikawa, Dusan Mandat, T. Montaruli, M. Mohammed, M. Iori, Oscar Blanch, Giovanni Bonanno, Benjamin Koch, M. A. Lopez, Julien Rousselle, M. Heller, Yusuke Konno, G. Maurin, J. Palacio, S. Gunji, C. Di Giulio, M. Zavrtanik, J.-P. Lenain, Adrian Biland, Michael Backes, Miroslav Filipovic, M. I. Martínez, M. Vazquez Acosta, Nicola Giglietto, J. M. Paredes, G. Fontaine, R. Moderski, A.A. Zdziarski, D. Tescaro, V. Vassiliev, C. van Eldik, H. Siejkowski, Stefan Kimeswenger, Shu Koyama, A. Bonardi, R. Gnatyk, S. Vorobiov, Oleh Petruk, M. Del Santo, Michał Szanecki, C. Delgado, Carole Mundell, Tomasz Szepieniec, Michael G. Burton, Bohdan Hnatyk, M. Capalbi, Kunihito Ioka, Jonathan Granot, Bohdan Novosyadlyj, Petr Schovanek, A. Weinstein, M. Stephan, Vikram V. Dwarkadas, L. Valore, Sabrina Einecke, P. Goldoni, J. Jacquemier, Hiroshi Muraishi, Andreas Quirrenbach, Takeshi Nakamori, Stefan Ohm, G. Busetto, Marcos Santander, A. Wierzcholska, Jaime Rosado, M. Yoshida, M. Huetten, S. Eschbach, Tatsuo Yoshida, Tomasz Bulik, Gino Tosti, Valentina Fioretti, Makoto Sawada, D. Zavrtanik, P. A. Caraveo, Mohamed Rameez, Sylvain Chaty, Nu. Komin, D. Dumas, Michael Zacharias, J. M. Huet, Reshmi Mukherjee, F. Lucarelli, L. Di Venere, Shuta J. Tanaka, F. de Palma, Shiu-Hang Lee, A. W. Chen, A. Giuliani, R. L. C. Starling, V. Beshley, Jonathan S. Lapington, Gilles Ferrand, Giovanni Covone, Rodrigo Nemmen, Tsuyoshi Inoue, R. C. Shellard, P. Cumani, G. Lamanna, Stefan Funk, Michele Doro, Koji Mori, G. Pühlhofer, Hidetoshi Sano, Susumu Inoue, Luis Ángel Tejedor, G. Kukec Mezek, Anderson Caproni, L. Freixas Coromina, M. de Naurois, D. Jankowsky, Yoshiyuki Inoue, Elina Lindfors, Saverio Lombardi, D. della Volpe, Giancarlo Cusumano, Andrea Orlati, S. Mangano, Samar Safi-Harb, Alexandre Marcowith, R. López-Coto, Martin Pohl, J. Lefaucheur, Vincenzo Rizi, Masayuki Tanaka, Shigehiro Nagataki, J. L. Rodriguez, Diego Falceta-Gonçalves, J. E. Ward, Petr Travnicek, I. Sadeh, Dominik Elsässer, P. Wilcox, Tsunefumi Mizuno, Kohta Murase, K. Lalik, M. Ostrowski, Vincenzo Testa, Tsuguya Naito, Matteo Cerruti, N. La Palombara, Yukikatsu Terada, Emmanuel Moulin, A. Balzer, M. Palatka, Samo Stanič, D. D'Urso, Łukasz Stawarz, D. Simone, Giuseppe Romeo, Francesco Giordano, Luca Zampieri, Michiko Ohishi, Giuseppe Leto, J.F. Glicenstein, G. De Cesare, Eleonora Torresi, R. A. Cameron, Katsuaki Asano, Ricardo Graciani, Gernot Maier, Paweł Wójcik, R. A. Ong, Jörg R. Hörandel, Carlo Vigorito, S. P. Wakely, Valerio Vagelli, Andrea Bulgarelli, J. Takeda, S. Brau-Nogué, Garret Cotter, Claudio Melioli, Hiroaki Yamamoto, M. Vrastil, Ryo Yamazaki, G. Maneva, N. Maxted, David A. Williams, K. Kosack, Konrad Bernlöhr, Markus Böttcher, Andreas Zech, Jürgen Knödlseder, Daniel Nieto, Paola Grandi, Maria Concetta Maccarone, Y. Inome, I. Telezhinsky, Fabio Acero, Michael C. B. Ashley, D. A. Sanchez, C. de Lisio, Francisco J. Franco, J. L. Dournaux, M. Kraus, G. Bonnoli, Xian Chen, Massimo Persic, Jonathan Blazek, Giacomo Principe, Louis Antonelli, H. Hakobyan, A. De Angelis, Marek Nikolajuk, F. Schüssler, T. Nagayoshi, P.-O. Petrucci, P. Sangiorgi, N. Sakaki, Anthony M. Brown, S. Tsujimoto, J. J. Rodríguez Vázquez, A. Morselli, B. De Lotto, Juan Carlos Helo, S. Nozaki, M. Takahashi, Lili Yang, H. Schoorlemmer, Catherine Braiding, Justin Vandenbroucke, J. A. Graham, P. Vallania, Stanislav Stefanik, M. Fesquet, Roberto Aloisio, Diego F. Torres, Ciro Bigongiari, C. Díaz, Shohei Yanagita, M. Garczarczyk, Abelardo Moralejo, Hideaki Katagiri, R. de los Reyes Lopez, A. Burtovoi, M. Hussein, Hiroyasu Tajima, M. Prouza, M. Renaud, C. Trichard, M. K. Daniel, Maria Chernyakova, Tarek M. Hassan, A. Ziegler, E. M. de Gouveia Dal Pino, Ll. Font, J. Kocot, Jiri Chudoba, J. P. Amans, Enrico Junior Schioppa, Alessandro Costa, Aya Bamba, A. Förster, F. Arqueros, Jan Ebr, M. Hayashida, A. J. Green, Marc Ribó, Olga Sergijenko, Hidetoshi Kubo, A. Porcelli, Tomohiro Inada, J. Biteau, J. Kushida, Jose Luis Contreras, S. Colafrancesco, Nestor Mirabal, V. Bugaev, R. J. García López, Vitalii Sliusar, I. Jung, Kathrin Egberts, G. Fasola, Maxim V. Barkov, Seiji Masuda, P. Romano, Enrico Cascone, V. I. Zhdanov, Elisa Prandini, Helene Sol, Rodolfo Carosi, S. Vercellone, Manuela Vecchi, German Martinez, A. Gadola, S. Griffiths, Satyendra Thoudam, Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPP), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CTA Consortium, High Energy Astrophys. & Astropart. Phys (API, FNWI), Acero F., Aloisio R., Amans J., Amato E., Antonelli L. A., Aramo C., Armstrong T., Arqueros F., Asano K., Ashley M., Backes M., Balazs C., Balzer A., Bamba A., Barkov M., Barrio J. A., Benbow W., Bernlöhr K., Beshley V., Bigongiari C., Biland A., Bilinsky A., Bissaldi E., Biteau J., Blanch O., Blasi P., Blazek J., Boisson C., Bonanno G., Bonardi A., Bonavolontà C., Bonnoli G., Braiding C., Brau-Nogué S., Bregeon J., Brown A. M., Bugaev V., Bulgarelli A., Bulik T., Burton M., Burtovoi A., Busetto G., Böttcher M., Cameron R., Capalbi M., Caproni A., Caraveo P., Carosi R., Cascone E., Cerruti M., Chaty S., Chen A., Chen X., Chernyakova M., Chikawa M., Chudoba J., Cohen-Tanugi J., Colafrancesco S., Conforti V., Contreras J. L., Costa A., Cotter G., Covino S., Covone G., Cumani P., Cusumano G., D’Ammando F., D’Urso D., Daniel M., Dazzi F., De Angelis A., De Cesare G., De Franco A., De Frondat F., de Gouveia Dal Pino E. M., De Lisio C., de los Reyes Lopez R., De Lotto B., de Naurois M., De Palma F., Del Santo M., Delgado C., della Volpe D., Di Girolamo T., Di Giulio C., Di Pierro F., Di Venere L., Doro M., Dournaux J., Dumas D., Dwarkadas V., Díaz C., Ebr J., Egberts K., Einecke S., Elsässer D., Eschbach S., Falceta-Goncalves D., Fasola G., Fedorova E., Fernández-Barral A., Ferrand G., Fesquet M., Fiandrini E., Fiasson A., Filipovíc M. D., Fioretti V., Font L., Fontaine G., Franco F. J., Coromina L. Freixa, Fujita Y., Fukui Y., Funk S., Förster A., Gadola A., López R. Garcia, Garczarczyk M., Giglietto N., Giordano F., Giuliani A., Glicenstein J., Gnatyk R., Goldoni P., Grabarczyk T., Graciani R., Graham J., Grandi P., Granot J., Green A. J., Griffiths S., Gunji S., Hakobyan H., Hara S., Hassan T., Hayashida M., Heller M., Helo J. C., Hinton J., Hnatyk B., Huet J., Huetten M., Humensky T. B., Hussein M., Hörandel J., Ikeno Y., Inada T., Inome Y., Inoue S., Inoue T., Inoue Y., Ioka K., Iori M., Jacquemier J., Janecek P., Jankowsky D., Jung I., Kaaret P., Katagiri H., Kimeswenger S., Kimura S., Knödlseder J., Koch B., Kocot J., Kohri K., Komin N., Konno Y., Kosack K., Koyama S., Kraus M., Kubo H., Mezek G. Kukec, Kushida J., Palombara N. La, Lalik K., Lamanna G., Landt H., Lapington J., Laporte P., Lee S., Lees J., Lefaucheur J., Lenain J.-P., Leto G., Lindfors E., Lohse T., Lombardi S., Longo F., Lopez M., Lucarelli F., Luque-Escamilla P. L., López-Coto R., Maccarone M. C., Maier G., Malaguti G., Mandat D., Maneva G., Mangano S., Marcowith A., Martí J., Martínez M., Martínez G., Masuda S., Maurin G., Maxted N., Melioli C., Mineo T., Mirabal N., Mizuno T., Moderski R., Mohammed M., Montaruli T., Moralejo A., Mori K., Morlino G., Morselli A., Moulin E., Mukherjee R., Mundell C., Muraishi H., Murase K., Nagataki S., Nagayoshi T., Naito T., Nakajima D., Nakamori T., Nemmen R., Niemiec J., Nieto D., Nievas-Rosillo M., Nikołajuk M., Nishijima K., Noda K., Nogues L., Nosek D., Novosyadlyj B., Nozaki S., Ohira Y., Ohishi M., Ohm S., Okumura A., Ong R. A., Orito R., Orlati A., Ostrowski M., Oya I., Padovani M., Palacio J., Palatka M., Paredes J. M., Pavy S., Pe’Er A., Persic M., Petrucci P., Petruk O., Pisarski A., Pohl M., Porcelli A., Prandini E., Prast J., Principe G., Prouza M., Pueschel E., Pühlhofer G., Quirrenbach A., Rameez M., Reimer O., Renaud M., Ribó M., Rico J., Rizi V., Rodriguez J., Fernandez G. Rodriguez, Vázquez J. J. Rodríguez, Romano P., Romeo G., Rosado J., Rousselle J., Rowell G., Rudak B., Sadeh I., Safi-Harb S., Saito T., Sakaki N., Sanchez D., Sangiorgi P., Sano H., Santander M., Sarkar S., Sawada M., Schioppa E. J., Schoorlemmer H., Schovanek P., Schussler F., Sergijenko O., Servillat M., Shalchi A., Shellard R. C., Siejkowski H., Sillanpää A., Simone D., Sliusar V., Sol H., Stanič S., Starling R., Stawarz Ł., Stefanik S., Stephan M., Stolarczyk T., Szanecki M., Szepieniec T., Tagliaferri G., Tajima H., Takahashi M., Takeda J., Tanaka M., Tanaka S., Tejedor L. A., Telezhinsky I., Temnikov P., Terada Y., Tescaro D., Teshima M., Testa V., Thoudam S., Tokanai F., Torres D. F., Torresi E., Tosti G., Townsley C., Travnicek P., Trichard C., Trifoglio M., Tsujimoto S., Vagelli V., Vallania P., Valore L., van Driel W., van Eldik C., Vandenbroucke J., Vassiliev V., Vecchi M., Vercellone S., Vergani S., Vigorito C., Vorobiov S., Vrastil M., Acosta M. L. Vázquez, Wagner S. J., Wagner R., Wakely S. P., Walter R., Ward J. E., Watson J. J., Weinstein A., White M., White R., Wierzcholska A., Wilcox P., Williams D. A., Wischnewski R., Wojcik P., Yamamoto T., Yamamoto H., Yamazaki R., Yanagita S., Yang L., Yoshida T., Yoshida M., Yoshiike S., Yoshikoshi T., Zacharias M., Zampieri L., Zanin R., Zavrtanik M., Zavrtanik D., Zdziarski A., Zech A., Zechlin H., Zhdanov V., Ziegler A., Zorn J., Acero, F., Aloisio, R., Amans, J., Amato, E., Antonelli, L. A., Aramo, C., Armstrong, T., Arqueros, F., Asano, K., Ashley, M., Backes, M., Balazs, C., Balzer, A., Bamba, A., Barkov, M., Barrio, J. A., Benbow, W., Bernlöhr, K., Beshley, V., Bigongiari, C., Biland, A., Bilinsky, A., Bissaldi, E., Biteau, J., Blanch, O., Blasi, P., Blazek, J., Boisson, C., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Braiding, C., Brau Nogué, S., Bregeon, J., Brown, A. M., Bugaev, V., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Böttcher, M., Cameron, R., Capalbi, M., Caproni, A., Caraveo, P., Carosi, R., Cascone, E., Cerruti, M., Chaty, S., Chen, A., Chen, X., Chernyakova, M., Chikawa, M., Chudoba, J., Cohen Tanugi, J., Colafrancesco, S., Conforti, V., Contreras, J. L., Costa, A., Cotter, G., Covino, S., Covone, G., Cumani, P., Cusumano, G., D’Ammando, F., D’Urso, D., Daniel, M., Dazzi, F., De Angelis, A., De Cesare, G., De Franco, A., De Frondat, F., de Gouveia Dal Pino, E. M., De Lisio, C., de los Reyes Lopez, R., De Lotto, B., de Naurois, M., De Palma, F., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Doro, M., Dournaux, J., Dumas, D., Dwarkadas, V., Díaz, C., Ebr, J., Egberts, K., Einecke, S., Elsässer, D., Eschbach, S., Falceta Goncalves, D., Fasola, G., Fedorova, E., Fernández Barral, A., Ferrand, G., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovíc, M. D., Fioretti, V., Font, L., Fontaine, G., Franco, F. J., Coromina, L. Freixa, Fujita, Y., Fukui, Y., Funk, S., Förster, A., Gadola, A., López, R. Garcia, Garczarczyk, M., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Green, A. J., Griffiths, S., Gunji, S., Hakobyan, H., Hara, S., Hassan, T., Hayashida, M., Heller, M., Helo, J. C., Hinton, J., Hnatyk, B., Huet, J., Huetten, M., Humensky, T. B., Hussein, M., Hörandel, J., Ikeno, Y., Inada, T., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Ioka, K., Iori, M., Jacquemier, J., Janecek, P., Jankowsky, D., Jung, I., Kaaret, P., Katagiri, H., Kimeswenger, S., Kimura, S., Knödlseder, J., Koch, B., Kocot, J., Kohri, K., Komin, N., Konno, Y., Kosack, K., Koyama, S., Kraus, M., Kubo, H., Mezek, G. Kukec, Kushida, J., Palombara, N. La, Lalik, K., Lamanna, G., Landt, H., Lapington, J., Laporte, P., Lee, S., Lees, J., Lefaucheur, J., Lenain, J. P., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, Francesco, Lopez, M., Lucarelli, F., Luque Escamilla, P. L., López Coto, R., Maccarone, M. C., Maier, G., Malaguti, G., Mandat, D., Maneva, G., Mangano, S., Marcowith, A., Martí, J., Martínez, M., Martínez, G., Masuda, S., Maurin, G., Maxted, N., Melioli, C., Mineo, T., Mirabal, N., Mizuno, T., Moderski, R., Mohammed, M., Montaruli, T., Moralejo, A., Mori, K., Morlino, G., Morselli, A., Moulin, E., Mukherjee, R., Mundell, C., Muraishi, H., Murase, K., Nagataki, S., Nagayoshi, T., Naito, T., Nakajima, D., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas Rosillo, M., Nikołajuk, M., Nishijima, K., Noda, K., Nogues, L., Nosek, D., Novosyadlyj, B., Nozaki, S., Ohira, Y., Ohishi, M., Ohm, S., Okumura, A., Ong, R. A., Orito, R., Orlati, A., Ostrowski, M., Oya, I., Padovani, M., Palacio, J., Palatka, M., Paredes, J. M., Pavy, S., Pe’Er, A., Persic, M., Petrucci, P., Petruk, O., Pisarski, A., Pohl, M., Porcelli, A., Prandini, E., Prast, J., Principe, G., Prouza, M., Pueschel, E., Pühlhofer, G., Quirrenbach, A., Rameez, M., Reimer, O., Renaud, M., Ribó, M., Rico, J., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Rosado, J., Rousselle, J., Rowell, G., Rudak, B., Sadeh, I., Safi Harb, S., Saito, T., Sakaki, N., Sanchez, D., Sangiorgi, P., Sano, H., Santander, M., Sarkar, S., Sawada, M., Schioppa, E. J., Schoorlemmer, H., Schovanek, P., Schussler, F., Sergijenko, O., Servillat, M., Shalchi, A., Shellard, R. C., Siejkowski, H., Sillanpää, A., Simone, D., Sliusar, V., Sol, H., Stanič, S., Starling, R., Stawarz, Ł., Stefanik, S., Stephan, M., Stolarczyk, T., Szanecki, M., Szepieniec, T., Tagliaferri, G., Tajima, H., Takahashi, M., Takeda, J., Tanaka, M., Tanaka, S., Tejedor, L. A., Telezhinsky, I., Temnikov, P., Terada, Y., Tescaro, D., Teshima, M., Testa, V., Thoudam, S., Tokanai, F., Torres, D. F., Torresi, E., Tosti, G., Townsley, C., Travnicek, P., Trichard, C., Trifoglio, M., Tsujimoto, S., Vagelli, V., Vallania, P., Valore, L., van Driel, W., van Eldik, C., Vandenbroucke, J., Vassiliev, V., Vecchi, M., Vercellone, S., Vergani, S., Vigorito, C., Vorobiov, S., Vrastil, M., Acosta, M. L. Vázquez, Wagner, S. J., Wagner, R., Wakely, S. P., Walter, R., Ward, J. E., Watson, J. J., Weinstein, A., White, M., White, R., Wierzcholska, A., Wilcox, P., Williams, D. A., Wischnewski, R., Wojcik, P., Yamamoto, T., Yamamoto, H., Yamazaki, R., Yanagita, S., Yang, L., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Zacharias, M., Zampieri, L., Zanin, R., Zavrtanik, M., Zavrtanik, D., Zdziarski, A., Zech, A., Zechlin, H., Zhdanov, V., Ziegler, A., Zorn, J., Acero et al, F., PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Acero, F, Aloisio, R, Amans, J, De Lisio, C, Di Girolamo, T, Valore, L, Covone, G, and Al., Et
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electron ,Supernova Remnants ,PARTICLE-ACCELERATION ,Cherenkov Telescope Array ,Astronomy ,leptonic ,Telescope Array Experiment ,pi ,Astrophysics ,01 natural sciences ,Supernova Remnant ,LARGE-AREA TELESCOPE ,Spectral line ,spectrum ,ISM: individual objects ,HESS ,Supernova remnant ,010303 astronomy & astrophysics ,cosmic ray ,Physics ,cosmic rays gamma rays: ISM ISM: individual objects (RX J1713.7-3946, G347.3-0.5) ,spatial distribution ,Gamma Ray ,Cherenkov radiation ,MAGNETIC-FIELD ,Gamma ray ,COSMIC-RAYS ,ISM: individual objects (RX J1713.7–3946, G347.3–0.5) ,Supernova ,cosmic rays ,gamma rays: ISM ,ISM: individual objects (RX J1713.7-3946, G347.3-0.5) ,Astronomy and Astrophysics ,Space and Planetary Science ,gamma ray: emission ,G347.3–0.5 ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,DIFFUSIVE SHOCK ACCELERATION ,Electrónica ,Física nuclear ,Electricidad ,individual objects: RX J1713.7–3946 [ISM] ,Compton scattering ,Gamma Rays ,G347.3-0.5) ,NONTHERMAL ,accelerator ,X-RAYS ,Astrophysics::High Energy Astrophysical Phenomena ,INSTABILITY ,Cosmic ray ,hadronic ,GLAST ,ISM: individual objects (RX J1713.7-3946 ,ISM [gamma rays] ,gas ,0103 physical sciences ,supernova ,ddc:530 ,X-ray: emission ,GAMMA-RAY EMISSION ,AMPLIFICATION ,BROAD-BAND EMISSION ,MOLECULAR CLOUDS ,STREAMING ,Astrophysics::Galaxy Astrophysics ,Astroparticle physics ,010308 nuclear & particles physics ,p: relativistic ,Institut für Physik und Astronomie ,ASTROFÍSICA ,gamma ray: VHE ,ddc:520 ,time dependence ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,RAIOS CÓSMICOS - Abstract
著者人数: 382名 (JAXA職員: 井上, 芳幸 : 小山, 志勇 : Lee, Shiu-Hang), Accepted: 2017-04-12, 資料番号: SA1170071000
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- 2017
162. Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay
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Laura Guerra, Alba Costales-Carrera, Pilar Bustamante-Madrid, Ramón Cantero, Antonio Barbáchano, A. Fernández-Barral, Alberto Muñoz, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Costales-Carrera, Alba, Fernández-Barral, A., Barbáchano, Antonio, Muñoz Terol, Alberto, Costales-Carrera, Alba [0000-0002-9075-1646], Fernández-Barral, A. [0000-0002-1278-4645], Barbáchano, Antonio [0000-0002-1248-5143], and Muñoz Terol, Alberto [0000-0003-3890-4251]
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3D culture ,Male ,Colorectal cancer ,Drug assay ,Pharmaceutical Science ,Phases of clinical research ,colorectal cancer ,Antineoplastic Agents ,Irinotecan ,Plocabulin ,Article ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma Cell ,Patient-derived organoids ,Drug Discovery ,Organoid ,Humans ,Cytotoxic T cell ,Medicine ,drug assay ,Precision Medicine ,Cytotoxicity ,lcsh:QH301-705.5 ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Aged ,030304 developmental biology ,Aged, 80 and over ,0303 health sciences ,3D cultures ,Dose-Response Relationship, Drug ,business.industry ,Reproducibility of Results ,medicine.disease ,Organoids ,Clinical trial ,lcsh:Biology (General) ,Pyrones ,Polyketides ,030220 oncology & carcinogenesis ,Cancer research ,Drug Screening Assays, Antitumor ,Colorectal Neoplasms ,business ,plocabulin ,patient-derived organoids ,medicine.drug - Abstract
This article belongs to the Special Issue 3D Cell Culture Based on Marine Resources., Plocabulin is a novel microtubule-disrupting antitumor agent of marine origin that is currently undergoing phase II clinical trials. Plocabulin has potent antiproliferative and antiangiogenic actions in carcinoma cell lines and has antitumor activity in xenografted mice. Here, we used three-dimensional (3D) tumor organoids derived from three colorectal cancer (CRC) patients to study the effect of plocabulin in a personalized assay system that ensures dose dependence and high reproducibility. The cytotoxicity of plocabulin was an order of magnitude higher than that of the active irinotecan derivative SN38 (7-ethyl-10-hydroxy-camptothecin) in tumor organoids at different passages. Moreover, plocabulin maintained its strong cytotoxic activity in wash-out experiments, in which a short pulse treatment of tumor organoids was as efficient as continuous treatment. Our data show that plocabulin has a very potent cytotoxic action in CRC patient-derived tumor organoids, supporting ongoing clinical trials with plocabulin and the use of organoid assays to provide personalized validation of antitumor drugs., This study was supported by grants SAF2016-76377-R (AEI/FEDER, UE), SAF2017-90604-REDT (Nurcamein) and ISCIII-CIBERONC CB16/12/00273 (to A.M.) from the Spanish Ministry of Science, Innovation and Universities.
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- 2019
163. Vitamin D Effects on Cell Differentiation and Stemness in Cancer
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Fernández-Barral, Asunción, primary, Bustamante-Madrid, Pilar, additional, Ferrer-Mayorga, Gemma, additional, Barbáchano, Antonio, additional, Larriba, María Jesús, additional, and Muñoz, Alberto, additional
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- 2020
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164. Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue
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Costales-Carrera, Alba, primary, Fernández-Barral, Asunción, additional, Bustamante-Madrid, Pilar, additional, Domínguez, Orlando, additional, Guerra-Pastrián, Laura, additional, Cantero, Ramón, additional, del Peso, Luis, additional, Burgos, Aurora, additional, Barbáchano, Antonio, additional, and Muñoz, Alberto, additional
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- 2020
- Full Text
- View/download PDF
165. Detection of persistent VHE gamma-ray emission from PKS 1510–089 by the MAGIC telescopes during low states between 2012 and 2017
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M. I. Martínez, P. Bangale, Sabrina Einecke, Jae-Young Kim, M. Makariev, Aaron Dominguez, Alicia Fattorini, G. Pedaletti, Ivica Puljak, Stefano Covino, B. De Lotto, Pierre Colin, J. Kushida, Jose Luis Contreras, Walter Max-Moerbeck, J. Becerra González, A. Arbet Engels, A. De Angelis, Vitaly Neustroev, M. Peresano, Chiara Righi, Juan Abel Barrio, D. Elsaesser, J. Palacio, Satoshi Masuda, J. E. Ward, Juan Cortina, Takashi Saito, Wrijupan Bhattacharyya, P. Temnikov, Sidika Merve Colak, Wolfgang Rhode, Giovanni Ceribella, I. Agudo, José L. Gómez, V. A. Acciari, Antonio Stamerra, D. Hadasch, D. Fidalgo, Camilla Maggio, Abelardo Moralejo, A. López-Oramas, P. Munar-Adrover, E. Moretti, Daniela Dorner, Pablo Peñil, Alexander Hahn, Dominik Baack, Gaia Vanzo, G. Maneva, E. Do Souto Espiñera, Joni Tammi, Adrian Biland, Elina Lindfors, Jürgen Besenrieder, C. M. Raiteri, Louis Antonelli, Sol N. Molina, Daniel Mazin, Ievgen Vovk, A. Berti, Francesco Dazzi, A. Fernández-Barral, K. Nishijima, Manuel Delfino, M. Gaug, R. J. García López, Nikola Godinovic, D. Dominis Prester, J. Rico, V. Ramakrishnan, Francesco Longo, Pratik Majumdar, D. Zarić, M. V. Fonseca, J. Herrera, T. Schweizer, Antonio Fuentes, Sebastian Kiehlmann, Marc Ribó, Ana Babić, A. Somero, Koji Noda, L. Maraschi, E. Prandini, Elisa Bernardini, P. Giammaria, V. Fallah Ramazani, John Hoang, Massimo Persic, Stefano Ansoldi, S. Paiano, Efthalia Traianou, Riccardo Paoletti, Tomislav Terzić, Ciro Bigongiari, Clemens Thum, B. Banerjee, P. G. Prada Moroni, Hidetoshi Kubo, C. Arcaro, J. van Scherpenberg, Karl Mannheim, I. Snidaric, Oscar Blanch, D. Kuveždić, Razmik Mirzoyan, U. Barres de Almeida, F. Leone, Carolina Casadio, Kari Nilsson, Damir Lelas, Anne Lähteenmäki, Masahiro Teshima, Stefan Cikota, M. Strzys, M. Will, Markus Garczarczyk, Dorota Sobczyńska, D. Ninci, M. Vazquez Acosta, Angela Sandrinelli, Cosimo Nigro, M. Nievas Rosillo, G. Ferrara, M. Minev, Victoria Moreno, G. Bonnoli, Kazuma Ishio, Yuki Iwamura, Susumu Inoue, Tarek M. Hassan, W. Bednarek, Fabrizio Tavecchio, Dario Hrupec, Luca Foffano, Ll. Font, L. Nogués, M. A. Lopez, Rodolfo Carosi, Mosè Mariotti, J. M. Paredes, J. R. Garcia, V. D'Elia, Saverio Lombardi, A. Rugliancich, Marina Manganaro, Ioannis Myserlis, D. Galindo, Merja Tornikoski, E. Molina, E. Colombo, Konstancja Satalecka, Michele Doro, Lab Saha, A. Niedzwiecki, David Paneque, D. Guberman, Jordi Delgado, F. Di Pierro, Talvikki Hovatta, P. Da Vela, Julian Sitarek, C. Fruck, N. Torres-Albà, Stefano Gallozzi, Jose Miguel Miranda, Alessandra Lamastra, T. Surić, Shimpei Tsujimoto, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., DI Pierro, F., Do Souto Espiñera, E., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuveždić, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Oramas, A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Becerra González, J., Raiteri, C. M., Sandrinelli, A., Hovatta, T., Kiehlmann, S., Max-Moerbeck, W., Tornikoski, M., Lähteenmäki, A., Tammi, J., Ramakrishnan, V., Thum, C., Agudo, I., Molina, S. N., Gómez, J. L., Fuentes, A., Casadio, C., Traianou, E., Myserlis, I., Kim, J. -Y., Metsähovi Radio Observatory, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Universitat de Barcelona, Federal Ministry of Education and Research (Germany), Max Planck Society, Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, and Junta de Andalucía
- Subjects
galaxies [Gamma rays] ,Astrophysics ,01 natural sciences ,7. Clean energy ,jet [Galaxies] ,law.invention ,Raigs gamma ,law ,Jets (Astrofísica) ,Broadband ,010303 astronomy & astrophysics ,Physics ,galaxies: active ,galaxies: jets ,gamma rays: galaxies ,quasars: individual: PKS 1510-089 ,galaxie [Gamma rays] ,Gamma ray ,Galaxies: active ,3. Good health ,Magnetic field ,Gamma rays: galaxies ,Spectral energy distribution ,Física nuclear ,Galaxies: jets ,Quasars: individual: PKS 1510-089 ,Astronomy and Astrophysics ,Space and Planetary Science ,Flare ,Spectral shape analysis ,active [Galaxies] ,astro-ph.GA ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,0103 physical sciences ,individual: PKS 1510-089 [Quasars] ,Quasars ,Quàsars ,Astrophysics::Galaxy Astrophysics ,010308 nuclear & particles physics ,Gamma rays ,Quasar ,Plasma ,Astronomy and Astrophysic ,Astrophysics - Astrophysics of Galaxies ,Astrophysical jets ,Astrophysics of Galaxies (astro-ph.GA) ,Galàxies actives ,Active galaxies ,ddc:520 ,jets [Galaxies] - Abstract
PKS 1510-089 is a flat spectrum radio quasar strongly variable in the optical and GeV range. To date, very high-energy (VHE, > 100 GeV) emission has been observed from this source either during long high states of optical and GeV activity or during short flares. Aims. We search for low-state VHE gamma-ray emission from PKS 1510-089. We characterize and model the source in a broadband context, which would provide a baseline over which high states and flares could be better understood. Methods. PKS 1510-089 has been monitored by the MAGIC telescopes since 2012. We use daily binned Fermi-LAT flux measurements of PKS 1510-089 to characterize the GeV emission and select the observation periods of MAGIC during low state of activity. For the selected times we compute the average radio, IR, optical, UV, X-ray, and gamma-ray emission to construct a low-state spectral energy distribution of the source. The broadband emission is modeled within an external Compton scenario with a stationary emission region through which plasma and magnetic fields are flowing. We also perform the emission-model-independent calculations of the maximum absorption in the broad line region (BLR) using two different models. Results. The MAGIC telescopes collected 75 hr of data during times when the Fermi-LAT flux measured above 1 GeV was below 3? × 10 -8 ? cm -2 ? s -1 , which is the threshold adopted for the definition of a low gamma-ray activity state. The data show a strongly significant (9.5¿) VHE gamma-ray emission at the level of (4.27 ± 0.61 stat ) × 10 -12 ? cm -2 ? s -1 above 150 GeV, a factor of 80 lower than the highest flare observed so far from this object. Despite the lower flux, the spectral shape is consistent with earlier detections in the VHE band. The broadband emission is compatible with the external Compton scenario assuming a large emission region located beyond the BLR. For the first time the gamma-ray data allow us to place a limit on the location of the emission region during a low gamma-ray state of a FSRQ. For the used model of the BLR, the 95% confidence level on the location of the emission region allows us to place it at a distance > 74% of the outer radius of the BLR. © ESO 2018., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, CSD2009-00064), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Exce-lencia “Severo Ochoa” SEV-2012-0234 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq and FAPERJ. IA acknowledges support from a Ramón y Cajal grant of the Ministerio de Economía, Industria, y Competitividad (MINECO) of Spain. Acquisition and reduction of the POLAMI and MAPCAT data was supported in part by MINECO through grants AYA2010-14844, AYA2013-40825-P, and AYA2016-80889-P, and by the Regional Government of Andalucía through grant P09-FQM-4784.
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- 2018
166. The Blazar TXS 0506+056 associated with a high-energy neutrino: insights into extragalactic jets and cosmic-ray acceleration
- Author
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M. Makariev, John Hoang, J. Besenrieder, J. Rico, W. Rhode, M. Vazquez Acosta, L. Nogués, J. Kushida, Simona Paiano, D. Hadasch, R. Ch. Berse, Jose Luis Contreras, Abelardo Moralejo, E. Moretti, K. Mielke, P. Da Vela, Ievgen Vovk, Francesco Dazzi, A. Fernández-Barral, M. I. Martínez, Juan Cortina, P. Bangale, A. Hahn, W. Bhattacharyya, K. Pfrang, F. Di Pierro, D. Fidalgo, M. Mariotti, K. Nishijima, G. Pedaletti, V. Moreno, G. Vanzo, S. Gallozzi, Sabrina Einecke, K. Mannheim, T. Saito, D. Dorner, C. Maggio, D. Dominis Prester, Stefano Covino, Matteo Cerruti, Marina Manganaro, Juan Abel Barrio, P. G. Prada Moroni, M. Strzys, S. Lombardi, P. Cumani, Konstancja Satalecka, Michele Doro, J. R. Garcia, P. Peñil, M. Minev, D. Lelas, F. Leone, B. De Lotto, Elisa Prandini, Rodolfo Carosi, Dario Hrupec, R. Paoletti, S. M. Colak, C. Arcaro, M. A. Lopez, M. Peresano, G. Ceribella, A. Niedzwiecki, M. V. Fonseca, Tarek M. Hassan, W. Bednarek, Ana Babić, David Paneque, Ciro Bigongiari, Petar Temnikov, Koji Noda, Elisa Bernardini, Stefano Ansoldi, Fabrizio Tavecchio, I. Šnidarić, Eduardo Colombo, Razmik Mirzoyan, Elina Lindfors, Ll. Font, Markus Gaug, D. Guberman, Daniel Mazin, A. Berti, J. Palacio, Christian Fruck, A. Fattorini, Tomislav Terzić, B. Banerjee, Dorota Sobczyńska, J. M. Paredes, Antonio Stamerra, Y. Iwamura, M. Hayashida, P. Giammaria, R. J. García López, Markus Garczarczyk, Francesco Longo, N. Godinović, Lab Saha, Pierre Colin, Kari Nilsson, G. Maneva, V. Fallah Ramazani, Marc Ribó, Massimo Persic, M. Will, Hidetoshi Kubo, Pratik Majumdar, D. Elsaesser, Jose Carlos Herrera, G. Ferrara, G. Bonnoli, Oscar Blanch, Jordi Delgado, M. Delfino, Julian Sitarek, Masahiro Teshima, T. Schweizer, D. Ninci, Chiara Righi, Satoshi Masuda, Arka Chatterjee, Yusuke Konno, I. Puljak, Laura Maraschi, C. Nigro, Darko Zarić, Luca Foffano, Aaron Dominguez, A. Lamastra, J. E. Ward, Shimpei Tsujimoto, A. Rugliancich, Vitaly Neustroev, Susumu Inoue, N. Torres-Albà, Valerio D'Elia, Dominik Baack, Adrian Biland, Jose Miguel Miranda, Tihomir Surić, Louis Antonelli, A. De Angelis, U. Barres de Almeida, M. Nievas Rosillo, K. Ishio, J. Becerra González, Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Berse, R. Ch., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D'Elia, V., Vela, P. Da, Dazzi, F., Angelis, A. De, Lotto, B. De, Delfino, M., Delgado, J., Pierro, F. Di, Domínguez, A., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Gallozzi, S., López, R. J. García, Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Konno, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nieva, Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Pfrang, K., Moroni, P. G. Prada, Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albá, N., Tsujimoto, S., Vanzo, G., Acosta, M. Vazquez, Vovk, I., Ward, J. E., Will, M., Zarić, D., Cerruti, Matteo, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), MAGIC, and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
- Subjects
neutrino: energy: high ,jets [galaxies] ,Electron ,Astrophysics ,individual (TXS 0506+056) [BL Lacertae objects] ,01 natural sciences ,neutrino ,Absorption (logic) ,MAGIC (telescope) ,010303 astronomy & astrophysics ,interaction [electron] ,cosmic ray ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,photon ,neutrinos ,520 Astronomie und zugeordnete Wissenschaften ,non-thermal [radiation mechanisms] ,Neutrino detector ,inverse [Compton scattering] ,electron: interaction ,galaxies [gamma rays] ,acceleration [cosmic radiation] ,Física nuclear ,Neutrino ,Astrophysics - High Energy Astrophysical Phenomena ,BL Lac object ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Cosmic ray ,VHE ,energy [p] ,blazar ,X-ray ,cosmic rays ,0103 physical sciences ,gamma rays: galaxies ,ddc:530 ,galaxie [gamma rays] ,energy: high [neutrino] ,cosmic radiation: acceleration ,Blazar ,plasma ,BL Lacertae objects: individual ,010308 nuclear & particles physics ,Astronomy and Astrophysics ,Astronomy and Astrophysic ,galaxies: jets ,radiation mechanisms: non-thermal ,530 Physik ,MAGIC ,BL Lacertae objects: individual (TXS 0506+056), cosmic rays, galaxies: jets, gamma rays: galaxies, neutrinos, radiation mechanisms: non-thermal, Astronomy and Astrophysics, Space and Planetary Science ,BL Lacertae objects: individual (TXS 0506+056) ,messenger ,electromagnetic ,Compton scattering: inverse ,p: energy ,jet [galaxies] ,gamma ray ,Space and Planetary Science ,ddc:520 ,High Energy Physics::Experiment ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,absorption - Abstract
A neutrino with energy of $\sim$290 TeV, IceCube-170922A, was detected in coincidence with the BL Lac object TXS~0506+056 during enhanced gamma-ray activity, with chance coincidence being rejected at $\sim 3\sigma$ level. We monitored the object in the very-high-energy (VHE) band with the MAGIC telescopes for $\sim$41 hours from 1.3 to 40.4 days after the neutrino detection. Day-timescale variability is clearly resolved. We interpret the quasi-simultaneous neutrino and broadband electromagnetic observations with a novel one-zone lepto-hadronic model, based on interactions of electrons and protons co-accelerated in the jet with external photons originating from a slow-moving plasma sheath surrounding the faster jet spine. We can reproduce the multiwavelength spectra of TXS 0506+056 with neutrino rate and energy compatible with IceCube-170922A, and with plausible values for the jet power of $\sim 10^{45} - 4 \times 10^{46} {\rm erg \ s^{-1}}$. The steep spectrum observed by MAGIC is concordant with internal $\gamma\gamma$ absorption above a few tens of GeV entailed by photohadronic production of a $\sim$290 TeV neutrino, corroborating a genuine connection between the multi-messenger signals. In contrast to previous predictions of predominantly hadronic emission from neutrino sources, the gamma-rays can be mostly ascribed to inverse Compton up-scattering of external photons by accelerated electrons. The X-ray and VHE bands provide crucial constraints on the emission from both accelerated electrons and protons. We infer that the maximum energy of protons in the jet co-moving frame can be in the range $\sim 10^{14}$ to $10^{18}$ eV., Comment: 11 pages, 3 figues, 3 tables, Accepted for publication in ApJL. Major changes in the revised Version: corrected author list
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- 2018
167. Multi-wavelength characterization of the blazar S5 0716+714 during an unprecedented outburst phase
- Author
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Mark Gurwell, Max Ludwig Ahnen, Elina Lindfors, D. Gasparrini, Antonio Stamerra, Daniel Mazin, J. Becerra González, Alessandro Carosi, B. De Lotto, Francesco Longo, A. Berti, Ievgen Vovk, G. A. Borman, Rodrigo Reeves, Abelardo Moralejo, M. Peresano, N. Torres-Albà, P. Giammaria, Helen Jermak, V. Fallah Ramazani, Juan Abel Barrio, G. Pedaletti, Adrian Biland, G. Bonnoli, M. Minev, I. Reichardt, T. Schweizer, D. Bastieri, I. Snidaric, Takashi Saito, I. Agudo, Stefano Gallozzi, Jose Miguel Miranda, Satoshi Masuda, R. J. García López, Alexander Hahn, Stefano Covino, Dario Hrupec, J. Kushida, J. Rico, J. Anton Zensus, Arka Chatterjee, Alan P. Marscher, Mosè Mariotti, M. A. Lopez, Dominik Baack, Yu. V. Troitskaya, Mitsunari Takahashi, A. C. S. Readhead, J. E. Ward, K. Mielke, D. Galindo, Aaron Dominguez, Jose Luis Contreras, Svetlana G. Jorstad, J. R. Garcia, D. Fidalgo, Massimo Persic, Pratik Majumdar, M. V. Fonseca, L. Maraschi, D. Kuveždić, K. Nishijima, D. Dominis Prester, J. M. Paredes, Sidika Merve Colak, E. N. Kopatskaya, D. J. Thompson, Juan Cortina, P. G. Prada Moroni, Giovanni Ceribella, Julian Sitarek, Stefano Ansoldi, Oscar Blanch, T. S. Grishina, Emmanouil Angelakis, Wrijupan Bhattacharyya, C. Fruck, Tomislav Terzić, Riccardo Paoletti, Chiara Righi, B. Lott, Jordi Delgado, A. Niedzwiecki, G. M. Madejski, D. Hadasch, F. Di Pierro, Saverio Lombardi, A. De Angelis, M. Strzys, Talvikki Hovatta, M. Vazquez Acosta, A. Treves, Vitaly Neustroev, L. V. Larionova, Ivan S. Troitsky, David Paneque, Yusuke Konno, L. Nogués, P. Temnikov, Andrea Rugliancich, Tarek M. Hassan, Krzysztof Nalewajko, W. Bednarek, Thomas P. Krichbaum, Sergey S. Savchenko, Victoria Moreno, Francesco Dazzi, A. Fernández-Barral, Ryosuke Itoh, P. Da Vela, Alexander Kraus, E. Moretti, Louis Antonelli, Fabrizio Tavecchio, Ll. Font, Bindu Rani, T. J. Pearson, Valeri M. Larionov, T. Nagayoshi, G. Maneva, D. Guberman, Manuel Delfino, Camilla Maggio, Daniela Dorner, Dariusz Gora, Gaia Vanzo, M. Gaug, S. Paiano, T. Surić, J. Herrera, Marina Manganaro, Shimpei Tsujimoto, Koji Noda, Ana Babić, Elisa Bernardini, Emilia Järvelä, Carolina Casadio, Anne Lähteenmäki, Masahiro Teshima, Karl Mannheim, Kari Nilsson, M. Will, Nikola Godinovic, Ioannis Myserlis, Merja Tornikoski, E. Colombo, Markus Garczarczyk, N. P. M. Kuin, L. O. Takalo, P. Cumani, Kazuma Ishio, Konstancja Satalecka, Michele Doro, Cosimo Nigro, M. Nievas Rosillo, Rodolfo Carosi, J. Palacio, V. Ramakrishnan, M. I. Martínez, P. Bangale, Sabrina Einecke, M. Makariev, E. Prandini, Iain A. Steele, Razmik Mirzoyan, U. Barres de Almeida, Damir Lelas, A. A. Vasilyev, Dorota Sobczyńska, Ivica Puljak, Pierre Colin, Sol N. Molina, D. A. Morozova, D. Ninci, A. Y. Lien, J. Hose, D. Elsaesser, Walter Max-Moerbeck, R. Ch. Berse, M. Hayashida, D. Zarić, Wolfgang Rhode, Marc Ribó, Hidetoshi Kubo, B. Banerjee, C. Arcaro, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), MAGIC, MWL, Fermi-LAT, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Ch Berse, R., Berti, A., Bhattacharyya, W., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Carosi, A., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Nagayoshi, T., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takahashi, M., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Treves, A., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Bastieri, D., Gasparrini, D., Lott, B., Rani, B., Thompson, D. J., Agudo, I., Angelakis, E., Borman, G. A., Casadio, C., Grishina, T. S., Gurwell, M., Hovatta, T., Itoh, R., Järvelä, E., Jermak, H., Jorstad, S., Kopatskaya, E. N., Kraus, A., Krichbaum, T. P., Kuin, N. P. M., Lähteenmäki, A., Larionov, V. M., Larionova, L. V., Lien, A. Y., Madejski, G., Marscher, A., Myserlis, I., Max-Moerbeck, W., Molina, S. N., Morozova, D. A., Nalewajko, K., Pearson, T. J., Ramakrishnan, V., Readhead, A. C. S., Reeves, R. A., Savchenko, S. S., Steele, I. A., Tornikoski, M., Troitskaya, Yu. V., Troitsky, I., Vasilyev, A. A., Anton Zensus, J., Japanese Government, Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, Istituto Nazionale di Astrofisica, Federal Ministry of Education and Research (Germany), Croatian Science Foundation, Polish Academy of Sciences, Centre National de la Recherche Scientifique (France), Ministério da Ciência e Tecnologia (Brasil), National Aeronautics and Space Administration (US), Academy of Finland, Smithsonian Institution, Academia Sinica (Taiwan), Russian Science Foundation, Junta de Andalucía, Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
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BL Lacertae objects: individual: S5 0716+714 ,galaxies: active ,galaxies: jets ,gamma rays: galaxies ,galaxies [Gamma rays] ,active [Galaxies] ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Galaxies: active ,Galaxies: jets ,Gamma rays: galaxies ,Astronomy and Astrophysics ,Space and Planetary Science ,7. Clean energy ,01 natural sciences ,jet [Galaxies] ,Radio spectrum ,0103 physical sciences ,Blazar ,010303 astronomy & astrophysics ,QC ,Astrophysics::Galaxy Astrophysics ,QB ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Superluminal motion ,galaxie [Gamma rays] ,010308 nuclear & particles physics ,Spectral density ,Astronomy and Astrophysic ,Light curve ,Redshift ,ddc:520 ,jets [Galaxies] ,Física nuclear ,individual: S5 0716+714 [BL Lacertae objects] ,gamma-rays: galaxies ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,BL Lac object ,Fermi Gamma-ray Space Telescope - Abstract
Context. The BL Lac object S5 0716+714, a highly variable blazar, underwent an impressive outburst in January 2015 (Phase A), followed by minor activity in February (Phase B). The MAGIC observations were triggered by the optical flux observed in Phase A, corresponding to the brightest ever reported state of the source in the R-band. Aims.The comprehensive dataset collected is investigated in order to shed light on the mechanism of the broadband emission. Methods. Multi-wavelength light curves have been studied together with the broadband spectral energy distributions (SEDs). The sample includes data from Effelsberg, OVRO, Metsähovi, VLBI, CARMA, IRAM, SMA, Swift-UVOT, KVA, Tuorla, Steward, RINGO3, KANATA, AZT-8+ST7, Perkins, LX-200, Swift-XRT, NuSTAR, Fermi-LAT and MAGIC. Results. The flaring state of Phase A was detected in all the energy bands, providing for the first time a multi-wavelength sample of simultaneous data from the radio band to the very-high-energy (VHE, E > 100 GeV). In the constructed SED, the Swift-XRT+NuSTAR data constrain the transition between the synchrotron and inverse Compton components very accurately, while the second peak is constrained from 0.1 GeV to 600 GeV by Fermi+MAGIC data. The broadband SED cannot be described with a one-zone synchrotron self-Compton model as it severely underestimates the optical flux in order to reproduce the X-ray to -ray data. Instead we use a two-zone model. The electric vector position angle (EVPA) shows an unprecedented fast rotation. An estimation of the redshift of the source by combined high-energy (HE, 0.1 GeV < E < 100 GeV) and VHE data provides a value of z = 0:31 ± 0:02 ± 0:05, confirming the literature value. Conclusions. The data show the VHE emission originating in the entrance and exit of a superluminal knot in and out of a recollimation shock in the inner jet. A shock-shock interaction in the jet seems responsible for the observed flares and EVPA swing. This scenario is also consistent with the SED modeling. © ESO 2018., We would like to thank the Instituto de Astrofisica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, CSD2009-00064), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia "Severo Ochoa" SEV-2012-0234 and SEV-2015-0548, and Unidad de Excelencia "Maria de Maeztu" MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ. The Fermi-LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat a l'Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucleaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d'Etudes Spatiales in France. This research was supported by an appointment to the NASA Postdoctoral Program at the Goddard Space Flight Center, administered by Universities Space Research Association through a contract with NASA. We thank the Swift team duty scientists and science planners., The Metsahovi team acknowledges the support from the Academy of Finland to our observing projects (numbers 212656, 210338, 121148, and others). The VLBA is an instrument of the Long Baseline Observatory. The Long Baseline Observatory is a facility of the National Science Foundation operated by Associated Universities, Inc. The Sub-millimeter Array is a joint project between the Smithsonian Astrophysical Observatory and the Academia Sinica Institute of Astronomy and Astrophysics and is funded by the Smithsonian Institution and the Academia Sinica. The OVRO 40-m monitoring program is supported in part by NASA grants NNX08AW31G, NNX11A043G and NNX14AQ89G, and NSF grants AST-0808050 and AST-1109911. The St. Petersburg University team acknowledges support from Russian Science Foundation grant 17-12-01029. The BU group acknowledges support by NASA under Fermi Guest Investigator grant NNX14AQ58G and by NSF under grant AST-1615796. Part of this work was done with funding by the UK Space Agency. The VLBA is an instrument of the National Radio Astronomy Observatory. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. The PRISM (Perkins Re-Imaging SysteM) camera at Lowell Observatory was developed by K. Janes et al. at BU and Lowell Observatory, with funding from the NSF, BU, and Lowell Observatory. This paper makes use of data obtained with the 100m Effelsberg radio-telescope, which is operated by the Max-Planck-Institut fur Radioastronomy (MPIfR) in Bonn (Germany). Part of this work is based on archival data, software or online services provided by the ASI Science Data Center (ASDC). PYRAF is a product of the Space Telescope Science Institute, which is operated by AURA for NASA. This paper is partly based on observations carried out with the IRAM 30 m. IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain). IA acknowledges support by a Ramon y Cajal grant of the Ministerio de Economia, Industria y Competitividad (MINECO) of Spain. The research at the IAA-CSIC was supported in part by the MINECO through grants AYA2016-80889-P, AYA2013-40825-P, and AYA2010-14844, and by the regional government of Andalucia through grant P09-FQM-4784. The Liverpool Telescope is operated by JMU with financial support from the UK-STFC.
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- 2018
168. Gamma-ray flaring activity of NGC 1275 in 2016-2017 measured by MAGIC
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Ansoldi, S., Antonelli, L. A., Bednarek, W., Niedzwiecki, A., Rosillo, M. Nievas, Nigro, Cosimo, Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Bernardini, E., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Pfrang, Konstantin Johannes, Moroni, P. G. Prada, Prandini, E., Berse, R. Ch, Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Berti, A., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takahashi, M., Tavecchio, F., Bhattacharyya, W., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Vanzo, G., Acosta, M. Vazquez, Vovk, I., Ward, J. E., Will, M., Bigongiari, C., Zarić, D., Glawion, D., Takalo, L. O., Jormanainen, J., Magic, Collaboration, Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Arcaro, C., Ceribella, G., Chatterjee, A., SIDIKA MERVE COLAK, Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D Elia, V., Baack, D., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Prester, D. Dominis, Dorner, D., Babić, A., Doro, M., Einecke, S., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Banerjee, B., Font, L., Fruck, C., Galindo, D., Gallozzi, S., López, R. J. García, Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Bangale, P., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hoang, J., Hose, J., Hrupec, D., Ishio, K., Almeida, U. Barres, Konno, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., Barrio, J. A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., González, J. Becerra, Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Nagayoshi, T., Neustroev, V., Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berse, R. Ch., Berti, A., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hoang, J., Hose, J., Hrupec, D., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Nagayoshi, T., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Pfrang, K., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Glawion, D., Takalo, L. O., and Jormanainen, J.
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Galaxies: active ,Galaxies: individual: NGC 1275 ,Galaxies: jets ,Gamma rays: galaxies ,Astronomy and Astrophysics ,Space and Planetary Science ,Radio galaxy ,Astrophysics::High Energy Astrophysical Phenomena ,galaxies: active ,jets [galaxies] ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,jet [Galaxies] ,law.invention ,law ,0103 physical sciences ,gamma rays: galaxies ,MAGIC (telescope) ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,galaxies: jets ,galaxies: individual: NGC 1275 ,galaxie [Gamma rays] ,010308 nuclear & particles physics ,Gamma ray ,Astronomy and Astrophysic ,Light curve ,Monitoring program ,Black hole ,Crab Nebula ,13. Climate action ,active [galaxies] ,galaxies [gamma rays] ,ddc:520 ,Física nuclear ,Astrophysics - High Energy Astrophysical Phenomena ,individual: NGC 1275 [galaxies] ,Flare - Abstract
We report on the detection of flaring activity from the Fanaroff-Riley I radio galaxy NGC 1275 in very-high-energy (VHE, E $>$ 100 GeV) gamma rays with the MAGIC telescopes. Observations were performed between 2016 September and 2017 February as part of a monitoring program. The brightest outburst with $\sim1.5$ times the Crab Nebula flux above 100 GeV (C.U.) was observed during the night between 2016 December 31 and 2017 January 1 (fifty times higher than the mean previously measured in two observational campaigns between 2009 and 2011). Significant variability of the day-by-day light curve was measured, the shortest flux-doubling time-scales was found to be of $(611\pm101)$ min. The combined spectrum of the MAGIC data during the strongest flare state and simultaneous data from the Fermi-LAT around 2017 January 1 follows a power-law with an exponential cutoff at the energy $(492\pm35)$ GeV. Simultaneous optical flux density measurements in the R-band obtained with the KVA telescope are also presented and the correlation between the optical and gamma-ray emission is investigated. Due to possible internal pair-production, the fast flux variability constrains the Doppler factor to values which are inconsistent with a large viewing angle as observed in the radio band. We investigate different scenarios for the explanation of fast gamma-ray variability, namely emission from: magnetospheric gaps, relativistic blobs propagating in the jet (mini-jets) or external cloud (or star) entering the jet. We find that the only plausible model to account for the luminosities here observed would be the production of gamma rays in a magnetospheric gap around the central black hole only in the eventuality of an enhancement of the magnetic field threading the hole from its equipartition value with the gas pressure in the accretion flow., accepted for publications in Astronomy and Astrophysics
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- 2018
169. Limits on the flux of tau neutrinos from 1 PeV to 3 EeV with the MAGIC telescopes
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Christian Fruck, L. Nogués, E. Moretti, Francesco Longo, Alba Fernández-Barral, Kazuma Ishio, Satoshi Masuda, Arka Chatterjee, D. Fidalgo, Yusuke Konno, M. Garczarczyk, L. Maraschi, Elina Lindfors, Ievgen Vovk, Ivica Puljak, Pierre Colin, J. R. Garcia, Daniel Mazin, A. Berti, M. I. Martínez, Rodolfo Carosi, Mosè Mariotti, Louis Antonelli, T. Schweizer, K. Mielke, Alessandro Carosi, B. De Lotto, Aaron Dominguez, Cosimo Nigro, M. Nievas Rosillo, T. Nagayoshi, Martin Makariev, N. Torres-Albà, M. Minev, Sabrina Einecke, Pratik Majumdar, M. V. Fonseca, Nikola Godinovic, J. E. Ward, J. Becerra González, Stefano Ansoldi, Riccardo Paoletti, Jose Miguel Miranda, Saverio Lombardi, Andrea Rugliancich, Abelardo Moralejo, Sidika Merve Colak, Stefano Covino, Tomislav Terzić, Oscar Blanch, P. G. Prada Moroni, G. Pedaletti, E. Colombo, Marcel Strzys, Masahiro Teshima, Wrijupan Bhattacharyya, J. Palacio, Julian Sitarek, J. Hose, K. Nishijima, Daniela Hadasch, R. Mirzoyan, Adrian Biland, Martin Will, J. M. Paredes, U. Barres de Almeida, I. Reichardt, L. O. Takalo, Antonio Stamerra, Tomoki Saito, Giovanni Ceribella, D. Elsaesser, R. Ch. Berse, Damir Lelas, M. Peresano, Marina Manganaro, D. Galindo, Shimpei Tsujimoto, Dominik Baack, Tihomir Surić, J. Rico, Dorota Sobczyńska, Wolfgang Rhode, S. Paiano, Chiara Righi, P. Cumani, Konstancja Satalecka, Michele Doro, Karl Mannheim, P. Temnikov, Dario Hrupec, Francesco Dazzi, M. Vazquez Acosta, Juan Abel Barrio, M. A. Lopez, Mitsunari Takahashi, Victoria Moreno, A. Niedzwiecki, R. J. García López, David Paneque, B. Banerjee, C. Arcaro, D. Guberman, E. Prandini, A. De Angelis, A. Treves, Vitaly Neustroev, Massimo Persic, D. Kuveždić, Jordi Delgado, G. Bonnoli, F. Di Pierro, Manuel Delfino, Camilla Maggio, Daniela Dorner, Dariusz Gora, Gaia Vanzo, M. Gaug, J. Herrera, G. Maneva, Koji Noda, Elisa Bernardini, P. Da Vela, Ana Babić, Kari Nilsson, J. Kushida, Jose Luis Contreras, Juan Cortina, Tarek M. Hassan, W. Bednarek, Fabrizio Tavecchio, Ll. Font, Max Ludwig Ahnen, P. Giammaria, I. Snidaric, M. Hayashida, D. Zarić, Marc Ribó, P. Bangale, Hidetoshi Kubo, D. Ninci, Alexander Hahn, D. Dominis Prester, V. Fallah Ramazani, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres de Almeida, U., Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Berse, R. Ch., Berti, A., Bhattacharyya, W., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Carosi, A., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Vela, P. Da, Dazzi, F., Angelis, A. De, Lotto, B. De, Delfino, M., Delgado, J., Pierro, F. Di, Domínguez, A., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Góra, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Nagayoshi, T., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takahashi, M., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Treves, A., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., and Zarić, D.
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Point source ,Astrophysics::High Energy Astrophysical Phenomena ,Tau neutrinos ,FOS: Physical sciences ,Astrophysics ,Cherenkov telescopes ,01 natural sciences ,law.invention ,law ,Tau neutrino ,0103 physical sciences ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,010303 astronomy & astrophysics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,Gamma-ray astronomy ,tau neutrinos ,Spectral index ,ta115 ,010308 nuclear & particles physics ,Horizon ,High Energy Physics::Phenomenology ,Astronomy and Astrophysics ,Cherenkov telescope ,ddc:540 ,High Energy Physics::Experiment ,Neutrino ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Lepton ,Flare - Abstract
Astroparticle physics 102, 77 - 88 (2018). doi:10.1016/j.astropartphys.2018.05.002, A search for tau neutrino induced showers with the MAGIC telescopes is presented. The MAGIC telescopes located at an altitude of 2200 m a.s.l. in the Canary Island of La Palma, can point towards the horizon or a few degrees below across an azimuthal range of about 80°. This provides a possibility to search for air showers induced by tau leptons arising from interactions of tau neutrinos in the Earth crust or the surrounding ocean. In this paper we show how such air showers can be discriminated from the background of very inclined hadronic showers by using Monte Carlo simulations. Taking into account the orography of the site, the point source acceptance and the event rates expected have been calculated for a sample of generic neutrino fluxes from photo-hadronic interactions in AGNs. The analysis of about 30 h of data taken towards the sea leads to a 90% C.L. point source limit for tau neutrinos in the energy range from 1.0 × 10$^{15}$ eV to 3.0 × 10$^{18}$ eV of about $E^{2}_{\nu_{\tau}} \times \phi (E_{\nu_{\tau}}) < 2.0 \times 10^{-4}$ GeV cm$^{-2} s^{-1}$ for an assumed power-law neutrino spectrum with spectral index $\gamma =−2$. However, with 300 h and in case of an optimistic neutrino flare model, limits of the level down to $E^{2}_{\nu_{\tau}} \times \phi (E_{\nu_{\tau}}) < 8.4 \times 10^{-6}$ GeV cm$^{-2} s^{-1}$ can be expected., Published by Elsevier Science, Amsterdam [u.a.]
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- 2018
170. The broad-band properties of the intermediate synchrotron peaked BL Lac S2 0109+22 from radio to VHE gamma rays
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F. Wierda, M. Peresano, Cosimo Nigro, Alexander Hahn, M. Nievas Rosillo, R. Reinthal, M. Hayashida, M. Minev, N. Mankuzhiyil, Julian Sitarek, Razmik Mirzoyan, U. Barres de Almeida, Nikola Godinovic, Damir Lelas, J. M. Paredes, Tomislav Terzić, Marc Ribó, Kazuma Ishio, Antonio Stamerra, Ievgen Vovk, Dorota Sobczyńska, M. Delfino, Wrijupan Bhattacharyya, Juan Abel Barrio, P. Bangale, Francesco Longo, D. Dominis Prester, Hidetoshi Kubo, B. De Lotto, J. E. Ward, Rodolfo Carosi, Camilla Maggio, Jenni Jormanainen, S. Paiano, M. Lopez, Karl Mannheim, P. G. Prada Moroni, Marcel Strzys, Ivica Puljak, John Hoang, Stefano Ciprini, Pierre Colin, Daniela Dorner, Gaia Vanzo, Dominik Baack, R. Desiante, Jordi Delgado, T. Schweizer, Fallah Ramazani, F. Di Pierro, M. Gaug, G. Ferrara, Anthony C. S. Readhead, D. Elsaesser, J. Becerra González, J. Herrera, G. Bonnoli, M. Vazquez Acosta, Talvikki Hovatta, Neustroev, L. Nogués, R. J. García López, Martin Makariev, Koji Noda, Elisa Bernardini, L. Maraschi, A. Niedzwiecki, Francesco Dazzi, A. Fernández-Barral, Elina Lindfors, K. Pfrang, Oscar Blanch, E. Moretti, Dario Hrupec, P. Da Vela, Pratik Majumdar, M. V. Fonseca, Darko Zarić, Aaron Dominguez, Daniel Mazin, A. Berti, Ciro Bigongiari, J. Palacio, Massimo Persic, F. Leone, Anne Lähteenmäki, Stefano Ansoldi, S Barcewicz, M. Garczarczyk, David Paneque, Masahiro Teshima, Martin Will, Riccardo Paoletti, Stefano Covino, Walter Max-Moerbeck, R. Ch. Berse, Sidika Merve Colak, Yuki Iwamura, Kyoshi Nishijima, D. Ninci, Abelardo Moralejo, J. R. Garcia, Susumu Inoue, D. Guberman, E. Prandini, Louis Antonelli, R. J. C. Vera, Alessandra Lamastra, M. I. Martínez, Tomoki Saito, Giovanni Ceribella, Marina Manganaro, Merja Tornikoski, Joni Tammi, Sabrina Einecke, P. Cumani, Chiara Righi, Konstancja Satalecka, Wolfgang Rhode, Michele Doro, P. Temnikov, K. Mielke, Iva Šnidarić, Sebastian Kiehlmann, B. Banerjee, Alicia Fattorini, C. Arcaro, Pablo Peñil, Shimpei Tsujimoto, Jürgen Besenrieder, Adrian Biland, Moreno, Tihomir Surić, J. Rico, Satoshi Masuda, Arka Chatterjee, P. Giammaria, D. Fidalgo, N. Torres-Albà, Tarek M. Hassan, G. Pedaletti, Yusuke Konno, W. Bednarek, Fabrizio Tavecchio, Ll. Font, A. De Angelis, Stefano Gallozzi, Jose Miguel Miranda, G. Maneva, Ana Babić, J. Kushida, Jose Luis Contreras, Juan Cortina, Kari Nilsson, E. Colombo, Lab Saha, Luca Foffano, L. O. Takalo, D. Hadasch, Mosè Mariotti, Saverio Lombardi, Andrea Rugliancich, D’Elia, Christian Fruck, Department of Electronics and Nanoengineering, Metsähovi Radio Observatory, Aalto-yliopisto, Aalto University, Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., de Almeida, U. Barre, Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Berse, R. Ch., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Gallozzi, S., García Łópez, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Konno, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Łópez, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Pfrang, K., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Ciprini, S., Desiante, R., Barcewicz, S., Hovatta, T., Jormanainen, J., Takalo, L., Reinthal, R., Mankuzhiyil, N., Wierda, F., Lähteenmäki, A., Tammi, J., Tornikoski, M., Vera, R. J. C., Kiehlmann, S., Max-Moerbeck, W., Readhead, A. C. S., Ciprini , S., and Desiante , R.
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galaxie [Gamma-rays] ,active [Galaxies] ,Astrophysics::High Energy Astrophysical Phenomena ,Population ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,jet [Galaxies] ,Luminosity ,0103 physical sciences ,BL Lacertae objects: individual: S2 0109+22 ,Galaxies: active ,Galaxies: jets ,Gamma-rays: galaxies ,Astronomy and Astrophysics ,Space and Planetary Science ,MAGIC (telescope) ,Blazar ,education ,010303 astronomy & astrophysics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,education.field_of_study ,ta115 ,010308 nuclear & particles physics ,galaxies: active ,galaxies: jets ,gamma-rays: galaxies ,Optical polarization ,individual: S2 0109+22 [BL Lacertae objects] ,Astronomy and Astrophysic ,Redshift ,13. Climate action ,ddc:520 ,Spectral energy distribution ,Física nuclear ,Astrophysics - High Energy Astrophysical Phenomena ,BL Lac object - Abstract
The MAGIC telescopes observed S2 0109+22 in 2015 July during its flaring activity in high energy gamma rays observed by Fermi-LAT. We analyse the MAGIC data to characterise the very high energy (VHE) gamma-ray emission of S2 0109+22, which belongs to the subclass of intermediate synchrotron peak (ISP) BL Lac objects. We study the multi-frequency emission in order to investigate the source classification. Finally, we compare the source long-term behaviour to other VHE gamma-ray emitting (TeV) blazars. We performed a temporal and spectral analysis of the data centred around the MAGIC interval of observation (MJD 57225-57231). Long-term radio and optical data have also been investigated using the discrete correlation function. The redshift of the source is estimated through optical host-galaxy imaging and also using the amount of VHE gamma-ray absorption. The quasi-simultaneous multi-frequency spectral energy distribution (SED) is modelled with the conventional one-zone synchrotron self-Compton (SSC) model. MAGIC observations resulted in the detection of the source at a significance level of $5.3\,\sigma$. The VHE gamma-ray emission of S2 0109+22 is variable on a daily time scale. VHE gamma-ray luminosity of the source is lower than the average of TeV BL Lacs. The optical polarization, and long-term optical/radio behaviour of the source are different from the general population of TeV blazars. All these findings agree with the classification of the source as an ISP BL Lac object. We estimate the source redshift as $z = 0.36 \pm 0.07$. The SSC parameters describing the SED are rather typical for blazars., Comment: 15 pages, 10 figures, Corresponding authors: Fallah Ramazani, V. (vafara@utu.fi), Hovatta, T. (talvikki.hovatta@utu.fi), Lindfors, E. (elilin@utu.fi) and Nilsson, K. (kani@utu.fi)
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- 2018
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171. Constraining very-high-energy and optical emission from FRB 121102 with the MAGIC telescopes
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D. Elsaesser, Satoshi Masuda, Alessandra Lamastra, A. Hahn, Stefano Covino, K. Nishijima, Francesco Longo, Kazumi Kashiyama, Arka Chatterjee, Marc Ribó, Pierre Colin, D. Hadasch, J. Becerra González, Oscar Blanch, Julian Sitarek, P. Bangale, Abelardo Moralejo, Hidetoshi Kubo, W. Bhattacharyya, W. Rhode, J. Kushida, Jose Luis Contreras, J. Rico, P. Giammaria, Laura Spitler, F. Leone, M. Minev, L. Maraschi, E. Colombo, Juan Cortina, I. Puljak, Masahiro Teshima, G. Ferrara, Jordi Delgado, M. Vazquez Acosta, M. López, G. Bonnoli, J. Palacio, T. Schweizer, E. Molina, Victoria Moreno, Chiara Righi, J. M. Paredes, Antonio Stamerra, M. Delfino, Francesco Dazzi, A. Fernández-Barral, Jason W. T. Hessels, N. Torres-Albà, B. Banerjee, C. Arcaro, J. R. Garcia, Darko Zarić, P. Da Vela, Iva Šnidarić, D. Baack, D. Ninci, Jürgen Besenrieder, Alicia Fattorini, D. Dominis Prester, F. Di Pierro, M. Peresano, M. Makariev, A. Arbet Engels, Vitaly Neustroev, Lab Saha, Luca Foffano, Pablo Peñil, R. J. García López, Stefano Gallozzi, Jose Miguel Miranda, A. Somero, V. D'Elia, Aaron Dominguez, A. Niedzwiecki, J. E. Ward, C. Fruck, Ciro Bigongiari, Kari Nilsson, P. Majumdar, C. Nigro, G. Ceribella, Elina Lindfors, Juan Abel Barrio, L. Nogués, D. Dorner, M. Nievas Rosillo, M. Mariotti, S. M. Colak, M. Garczarczyk, D. Guberman, Kohta Murase, A. Rugliancich, Marina Manganaro, V. Fallah Ramazani, C. Maggio, G. Maneva, Daniel Mazin, Tomislav Terzić, Dario Hrupec, R. Paoletti, A. Berti, M. Will, A. López-Oramas, D. Paneque, N. Godinović, B. De Lotto, K. Mannheim, Tarek M. Hassan, W. Bednarek, Andrew Seymour, G. Pedaletti, Shimpei Tsujimoto, P. Cumani, Konstancja Satalecka, Michele Doro, Fabrizio Tavecchio, M. I. Martínez, Massimo Persic, V. A. Acciari, Ll. Font, Razmik Mirzoyan, P G Prada Moroni, Adrian Biland, Louis Antonelli, D. Lelas, G. Vanzo, E. Moretti, Ana Babić, Sabrina Einecke, A. De Angelis, Tihomir Surić, S. Paiano, K. Ishio, Dorota Sobczyńska, Benito Marcote, Stefano Ansoldi, D. Fidalgo, Markus Gaug, M. V. Fonseca, Saverio Lombardi, John Hoang, Takashi Saito, U. Barres de Almeida, Elisa Prandini, Rodolfo Carosi, Susumu Inoue, Daniele Michilli, Y. Iwamura, M. Strzys, D. Kuveždić, I. Vovk, Valentí Bosch-Ramon, Jose Carlos Herrera, Petar Temnikov, Koji Noda, Elisa Bernardini, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., de Almeida, U. Barre, Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Gallozzi, S., López, R. J. García, Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuveždić, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Oramas, A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nieva, Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Moroni, P. G. Prada, Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Vanzo, G., Acosta, M. Vazquez, Vovk, I., Ward, J. E., Will, M., Zarić, D., Marcote, B., Spitler, L. G., Hessels, J. W. T., Kashiyama, K., Murase, K., Bosch-Ramon, V., Michilli, D., Seymour, A., Universitat de Barcelona, and ITA
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High energy ,Photon ,Radiation mechanisms: non-thermal ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,Radiació ,Raigs gamma ,radiation mechanisms: non-thermal ,methods: data analysis ,methods: observational ,gamma-rays: general ,Methods: observational ,Methods: data analysis ,0103 physical sciences ,Gamma ray astronomy ,Astronomia de raigs gamma ,observational [Methods] ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Millisecond ,general [Gamma-rays] ,ta115 ,Radiation ,non-thermal [Radiation mechanisms] ,010308 nuclear & particles physics ,Gamma rays ,Gamma ray ,Astronomy and Astrophysics ,Astronomy and Astrophysic ,Galaxy ,Redshift ,data analysi [Methods] ,Wavelength ,13. Climate action ,Space and Planetary Science ,Gamma-rays: general ,ddc:520 ,Física nuclear ,Optical emission spectroscopy ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Fast radio bursts (FRBs) are bright flashes observed typically at GHz frequencies with millisecond duration, whose origin is likely extragalactic. Their nature remains mysterious, motivating searches for counterparts at other wavelengths. FRB 121102 is so far the only source known to repeatedly emit FRBs and is associated with a host galaxy at redshift $z \simeq 0.193$. We conducted simultaneous observations of FRB 121102 with the Arecibo and MAGIC telescopes during several epochs in 2016--2017. This allowed searches for millisecond-timescale burst emission in very-high-energy (VHE) gamma rays as well as the optical band. While a total of five FRBs were detected during these observations, no VHE emission was detected, neither of a persistent nature nor burst-like associated with the FRBs. The average integral flux upper limits above 100 GeV at 95% confidence level are $6.6 \times 10^{-12}~\mathrm{photons\ cm^{-2}\ s^{-1}}$ (corresponding to luminosity $L_{\rm VHE} \lesssim 10^{45}~\mathrm{erg\ s^{-1}}$) over the entire observation period, and $1.2 \times 10^{-7}~ \mathrm{photons\ cm^{-2}\ s^{-1}}$ ($L_{\rm VHE} \lesssim 10^{49}~\mathrm{erg\ s^{-1}}$) over the total duration of the five FRBs. We constrain the optical U-band flux to be below 8.6 mJy at 5-$\sigma$ level for 1-ms intervals around the FRB arrival times. A bright burst with U-band flux $29~\mathrm{mJy}$ and duration $\sim 12$ ms was detected 4.3 s before the arrival of one FRB. However, the probability of spuriously detecting such a signal within the sampled time space is 1.5% (2.2 $\sigma$, post-trial), i.e. consistent with the expected background. We discuss the implications of the obtained upper limits for constraining FRB models., Comment: 9 pages, 3 figures. Accepted for publication in MNRAS the 2nd September 2018
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- 2018
172. Detection of the blazar S4 0954+65 at very-high-energy with the MAGIC telescopes during an exceptionally high optical state
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M. Hayashida, Satoshi Masuda, Arka Chatterjee, Juan Abel Barrio, D. Fidalgo, Yu. V. Troitskaya, Svetlana G. Jorstad, Emilia Järvelä, Marc Ribó, J. A. Acosta Pulido, Wrijupan Bhattacharyya, L. Maraschi, Kari Nilsson, P. Bangale, Hidetoshi Kubo, J. Hose, Stefano Ansoldi, Yusuke Konno, D. Elsaesser, Riccardo Paoletti, Tomislav Terzić, Francesco Longo, Elina Lindfors, P. G. Prada Moroni, Daniel Mazin, G. A. Borman, Alessandro Carosi, V. Fallah Ramazani, J. Palacio, D. Ninci, Kazuma Ishio, Pratik Majumdar, A. Berti, J. M. Paredes, Antonio Stamerra, N. Torres-Albà, J. Kushida, M. V. Fonseca, Jose Luis Contreras, M. Peresano, M. Makariev, G. Bonnoli, D. Kuveždić, Tarek M. Hassan, W. Bednarek, G. Pedaletti, Juan Cortina, Fabrizio Tavecchio, Martin Will, Chiara Righi, R. Ch. Berse, Ll. Font, Razmik Mirzoyan, Rodolfo Carosi, Dario Hrupec, Jose Miguel Miranda, J. Becerra González, M. A. Lopez, J. R. Garcia, Marina Manganaro, U. Barres de Almeida, P. Temnikov, E. Colombo, Oscar Blanch, T. S. Grishina, Mitsunari Takahashi, Stefano Covino, Louis Antonelli, Damir Lelas, Valeri M. Larionov, Aaron Dominguez, D. Galindo, Merja Tornikoski, Sergey S. Savchenko, Francesco Dazzi, Manuel Delfino, D. Dominis Prester, Wolfgang Rhode, Nikola Godinovic, Shimpei Tsujimoto, Tomoki Saito, Giovanni Ceribella, A. A. Vasilyev, Ana Babić, P. Cumani, L. O. Takalo, Konstancja Satalecka, L. Nogués, Michele Doro, Max Ludwig Ahnen, Dorota Sobczyńska, R. Ojha, K. Mielke, J. Finke, E. Moretti, Ievgen Vovk, P. Giammaria, Jordi Delgado, F. Di Pierro, Camilla Maggio, Daniela Dorner, Dariusz Gora, M. Gaug, G. Vanzo, C. Protasio, J. Herrera, D. Hadasch, Alba Fernández-Barral, Carolina Casadio, Anne Lähteenmäki, Mosè Mariotti, Masahiro Teshima, Alexander Hahn, E. Prandini, Cosimo Nigro, M. Nievas Rosillo, T. Nagayoshi, Kyoshi Nishijima, M. Minev, Iva Šnidarić, T. Schweizer, J. E. Ward, Sidika Merve Colak, E. N. Kopatskaya, A. Niedzwiecki, Koji Noda, Elisa Bernardini, Ivan S. Troitsky, David Paneque, D. Guberman, Saverio Lombardi, Andrea Rugliancich, V. Ramakrishnan, M. I. Martínez, Sabrina Einecke, Ivica Puljak, Pierre Colin, Markus Garczarczyk, M. I. Carnerero, Talvikki Hovatta, Sol N. Molina, P. Da Vela, Julian Sitarek, S. Paiano, Karl Mannheim, D. A. Morozova, A. De Angelis, A. Treves, Vitaly Neustroev, M. Vazquez Acosta, L. V. Larionova, G. Maneva, I. Agudo, Adrian Biland, Tihomir Surić, J. Rico, Dominik Baack, Alan P. Marscher, Christian Fruck, Victoria Moreno, Darko Zarić, B. De Lotto, Abelardo Moralejo, I. Reichardt, Mark Gurwell, B. Banerjee, Marcel Strzys, C. Arcaro, R. J. García López, Massimo Persic, Yasuyuki T. Tanaka, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Bednarek, W., Bernardini, E., Berse, R. Ch., Berti, A., Bhattacharyya, W., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Carosi, A., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Nagayoshi, T., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takahashi, M., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Treves, A., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Becerra González, J., Tanaka, Y., Ojha, R., Finke, J., Lähteenmäki, A., Järvelä, E., Tornikoski, M., Ramakrishnan, V., Hovatta, T., Jorstad, S. G., Marscher, A. P., Larionov, V. M., Borman, G. A., Grishina, T. S., Kopatskaya, E. N., Larionova, L. V., Morozova, D. A., Savchenko, S. S., Troitskaya, Yu. V., Troitsky, I. S., Vasilyev, A. A., Agudo, I., Molina, S. N., Casadio, C., Gurwell, M., Carnerero, M. I., Protasio, C., Acosta Pulido, J. A., Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, Federal Ministry of Education and Research (Germany), Junta de Andalucía, Max Planck Society, Universitat de Barcelona, Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
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individual: S4 0954+65 [BL Lacertae objects] ,Active galactic nucleus ,active [Galaxies] ,BL Lacertae objects: individual: S4 0954+65 ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,Galaxies: active ,Gamma rays: galaxies ,Astronomy and Astrophysics ,Space and Planetary Science ,0103 physical sciences ,Gamma ray astronomy ,Astronomia de raigs gamma ,gamma rays:galaxies ,galaxies:active ,BL Lacertae objects:individual:S40954+65 ,Blazar ,010303 astronomy & astrophysics ,Quasars ,Astrophysics::Galaxy Astrophysics ,Quàsars ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,gamma rays: galaxies ,galaxies: active ,galaxie [Gamma rays] ,010308 nuclear & particles physics ,Compton scattering ,Optical polarization ,Quasar ,Astronomy and Astrophysic ,Galaxies ,Redshift ,Galàxies ,galaxies [gamma rays] ,ddc:520 ,Spectral energy distribution ,Física nuclear ,Astrophysics - High Energy Astrophysical Phenomena ,Radio wave - Abstract
The very high energy (VHE ¿ 100 GeV) -ray MAGIC observations of the blazar S4 0954+65, were triggered by an exceptionally high flux state of emission in the optical. This blazar has a disputed redshift of z = 0.368 or z ¿ 0.45 and an uncertain classification among blazar subclasses. The exceptional source state described here makes for an excellent opportunity to understand physical processes in the jet of S4 0954+65 and thus contribute to its classification. Methods. We investigated the multiwavelength (MWL) light curve and spectral energy distribution (SED) of the S4 0954+65 blazar during an enhanced state in February 2015 and have put it in context with possible emission scenarios. We collected photometric data in radio, optical, X-ray, and ¿-ray. We studied both the optical polarization and the inner parsec-scale jet behavior with 43 GHz data. Results. Observations with the MAGIC telescopes led to the first detection of S4 0954+65 at VHE. Simultaneous data with Fermi-LAT at high energy ¿-ray(HE, 100 MeV < E < 100 GeV) also show a period of increased activity. Imaging at 43 GHz reveals the emergence of a new feature in the radio jet in coincidence with the VHE flare. Simultaneous monitoring of the optical polarization angle reveals a rotation of approximately 100. Conclusions. The high emission state during the flare allows us to compile the simultaneous broadband SED and to characterize it in the scope of blazar jet emission models. The broadband spectrum can be modeled with an emission mechanism commonly invoked for flat spectrum radio quasars (FSRQs), that is, inverse Compton scattering on an external soft photon field from the dust torus, also known as external Compton. The light curve and SED phenomenology is consistent with an interpretation of a blob propagating through a helical structured magnetic field and eventually crossing a standing shock in the jet, a scenario typically applied to FSRQs and low-frequency peaked BL Lac objects (LBL). © ESO 2018., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, CSD2009-00064), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2012-0234 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq, and FAPERJ. IA acknowledges support by a Ramón y Cajal grant of the Ministerio de Economía, Industria y Competitividad (MINECO) of Spain. The research at the IAA–CSIC was supported in part by the MINECO through grants AYA2016–80889–P, AYA2013–40825–P, and AYA2010–14844, and by the regional government of Andalucía through grant P09–FQM–4784.
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- 2018
173. El decúbito prono en una unidad de cuidados críticos: protocolo y plan de cuidados. Segunda parte
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Bénitez Canosa, María Cristina, Brea Fernández, Alejandro, Camino Castiñeiras, Miguel, Fernández Barral, Rosa, Fragua Mariño, María, Roca Vázquez, Josefa, and Villar Redondo, Rosario
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- 2005
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174. The endocrine vitamin D system in the gut
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Alba Costales-Carrera, Alberto Muñoz, A. Fernández-Barral, María Jesús Larriba, Gemma Ferrer-Mayorga, Antonio Barbáchano, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, and European Commission
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0301 basic medicine ,medicine.medical_specialty ,Intracrine ,Endocrine System ,Gut microbiota ,Inflammatory bowel diseases ,Gut flora ,Biochemistry ,Calcitriol receptor ,vitamin D deficiency ,Phosphates ,03 medical and health sciences ,Endocrinology ,Immune system ,Internal medicine ,medicine ,Vitamin D and neurology ,Animals ,Humans ,Vitamin D ,Autocrine signalling ,Gut homeostasis ,Molecular Biology ,biology ,Inflammatory Bowel Diseases ,medicine.disease ,biology.organism_classification ,Colorectal cancer ,Small intestine ,Gastrointestinal Microbiome ,Gastrointestinal Tract ,030104 developmental biology ,medicine.anatomical_structure ,Absorption, Physicochemical ,Gene Expression Regulation ,Receptors, Calcitriol ,Calcium ,Colorectal Neoplasms - Abstract
The active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) has important regulatory actions in the gut through endocrine and probably also intracrine, autocrine and paracrine mechanisms. By activating the vitamin D receptor (VDR), which is expressed at a high level in the small intestine and colon, 1,25(OH)2D3 regulates numerous genes that control gut physiology and homeostasis. 1,25(OH)2D3 is a major responsible for epithelial barrier function and calcium and phosphate absorption, and the host's defense against pathogens and the inflammatory response by several types of secretory and immune cells. Moreover, recent data suggest that 1,25(OH)2D3 has a regulatory effect on the gut microbiota and stromal fibroblasts. Many studies have linked vitamin D deficiency to inflammatory bowel diseases (ulcerative colitis and Crohn's disease) and to an increased risk of colorectal cancer, and the possible use of VDR agonists to prevent or treat these diseases is receiving increasing interest., The work in the authors' laboratory is supported by the Ministerio de Economía y Competitividad of Spain-Fondo Europeo de Desarrollo Regional (FEDER) (SAF2016-76377-R) and the Instituto de Salud Carlos III-FEDER (RD12/0036/0021, CB16/12/00273).
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- 2017
175. ʼLoss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanomaʼ
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Orgaz, J L, Ladhani, O, Hoek, K S, Fernández-Barral, A, Mihic, D, Aguilera, O, Seftor, E A, Bernad, A, Rodríguez-Peralto, J L, Hendrix, M JC, Volpert, O V, and Jiménez, B
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- 2009
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176. Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids
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Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Cantero, Ramón, Batlle, E., Barbáchano, Antonio, Muñoz Terol, Alberto, and Fernández-Barral, A.
- Abstract
Trabajo presentado en el II Encuentro de Jóvenes Investigadores de CIBERONC, celebrado en Madrid (España) el 27 de noviembre de 2019.
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- 2019
177. Urothelial organoids originate from mouse cells display differentiation capacity
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Catarina P. Santos, Eleonora Lapi, Antonio Barbáchano, Alberto Muñoz, A. Fernández-Barral, and Francisco X. Real
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Organoid ,Biology ,Cell biology - Abstract
Here we describe the establishment of mouse urothelial organoids from healthy urothelial tissue digests. NMU-o can grow within 7 days in medium enriched in growth factors, without FACS-sorting epithelial populations and can be passaged in culture for more than one year with stable morphology. In the absence of growth factors, NMU-o can differentiate within 14days exhibiting drastic morphological changes (increased diameter and lumen size, and decreased thickness layers) and expressing suprabasal urothelial markers (uroplakins and tigh junctions) both at the mRNA and protein levels. Transcriptomic tools (RNA-seq and single-cell RNA-seq) were preformed further supporting this differences between proliferative and differentiated organoids, allowing the discovery of novel genes involved in these processes.
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- 2019
178. Measurement of the Extragalactic Background Light using MAGIC and Fermi-LAT gamma-ray observations of blazars up to z = 1
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Acciari, V A, Ansoldi, S, Antonelli, L A, Arbet , Engels, A, Baack, D, Babić, A, Banerjee, B, Barresundefined, deundefined, Almeida, U, Barrio, J A, Becerraundefined, González, J, Bednarek, W, Bellizzi, L, Bernardini, E, Berti, A, Besenrieder, J, Bhattacharyya, W, Bigongiari, C, Biland, A, Blanch, O, Bonnoli, G, Busetto, G, Carosi, R, Ceribella, G, Chai, Y, Cikota, S, Colak, S M, Colin, U, Colombo, E, Contreras, J L, Cortina, J, Covino, S, D’Elia, V, Daundefined, Vela, P, Dazzi, F, Deundefined, Angelis, A, Lotto, B, Delfino, M, Delgado, J, Diundefined, Pierro, F, Doundefined, Soutoundefined, Espiñeira, E, Domínguez, A, Dominisundefined, Prester, D, Dorner, D, Doro, M, Elsaesser, D, Fallahundefined, Ramazani, V, Fattorini, A, Fernández-Barral, A, Ferrara, G, Fidalgo, D, Foffano, L, Fonseca, M V, Font, L, Fruck, C, Galindo, D, Gallozzi, S, Garcíaundefined, López, R J, Garczarczyk, M, Gasparyan, S, Gaug, M, Godinović, N, Green, D, Guberman, D, Hadasch, D, Hahn, A, Hassan, T, Herrera, J, Hoang, J, Hrupec, D, Inoue, S, Ishio, K, Iwamura, Y, Kubo, H, Kushida, J, Lamastra, A, Lelas, D, Leone, F, Lindfors, E, Lombardi, S, Longo, F, López, M, López-Coto, R, López-Oramas, A, Machadoundefined, Oliveiraundefined, Fraga, B, Maggio, C, Majumdar, P, Makariev, M, Mallamaci, M, Maneva, G, Manganaro, M, Mannheim, K, Maraschi, L, Mariotti, M, Martínez, M, Masuda, S, Mazin, D, Mićanović, S, Miceli, D, Minev, M, Miranda, J M, Mirzoyan, R, Molina, E, Moralejo, A, Morcuende, D, Moreno, V, Moretti, E, Munar-Adrover, P, Neustroev, V, Niedzwiecki, A, Nievasundefined, Rosillo, M, Nigro, C, Nilsson, K, Ninci, D, Nishijima, K, Noda, K, Nogués, L, Nöthe, M, Paiano, S, Palacio, J, Palatiello, M, Paneque, D, Paoletti, R, Paredes, J M, Peñil, P, Peresano, M, Persic, M, Pradaundefined, Moroni, P G, Prandini, E, Puljak, I, Rhode, W, Ribó, M, Rico, J, Righi, C, Rugliancich, A, Saha, L, Sahakyan, N, Saito, T, Satalecka, K, Schweizer, T, Sitarek, J, Šnidarić, I, Sobczynska, D, Somero, A, Stamerra, A, Strom, D, Strzys, M, Surić, T, Tavecchio, F, Temnikov, P, Terzić, T, Teshima, M, Torres-Albà, N, Tsujimoto, S, vanundefined, Scherpenberg, J, Vanzo, G, Vázquezundefined, Acosta, M, Vovk, I, Will, M, Zarić, D, Acciar, V. A., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Do Souto Espineira, E., Dominguez, A., Dominis Prester, D., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., MacHado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suric, T., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., and Zaric, D.
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gamma-rays: galaxies ,Astrophysics::High Energy Astrophysical Phenomena ,galaxies: active ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,galaxies [infrared] ,01 natural sciences ,infrared: galaxies ,diffuse background [infrared] ,0103 physical sciences ,galaxies: active, gamma-rays: galaxies, infrared: diffuse background, infrared: galaxies ,galaxie [gamma-rays] ,Blazar ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Luminous infrared galaxy ,Physics ,infrared: diffuse background ,010308 nuclear & particles physics ,Gamma ray ,Astronomy and Astrophysics ,Galaxy ,Redshift ,Stars ,galaxies [gamma-rays] ,Extragalactic background light ,Space and Planetary Science ,active [galaxies] ,ddc:520 ,Astrophysics - High Energy Astrophysical Phenomena ,Fermi Gamma-ray Space Telescope - Abstract
We present a measurement of the extragalactic background light (EBL) based on a joint likelihood analysis of 32 gamma-ray spectra for 12 blazars in the redshift range z = 0.03 to 0.944, obtained by the MAGIC telescopes and Fermi-LAT. The EBL is the part of the diffuse extragalactic radiation spanning the ultraviolet, visible and infrared bands. Major contributors to the EBL are the light emitted by stars through the history of the universe, and the fraction of it which was absorbed by dust in galaxies and re-emitted at longer wavelengths. The EBL can be studied indirectly through its effect on very-high energy photons that are emitted by cosmic sources and absorbed via photon-photon interactions during their propagation across cosmological distances. We obtain estimates of the EBL density in good agreement with state-of-the-art models of the EBL production and evolution. The 1-sigma upper bounds, including systematic uncertainties, are between 13% and 23% above the nominal EBL density in the models. No anomaly in the expected transparency of the universe to gamma rays is observed in any range of optical depth.We also perform a wavelength-resolved EBL determination, which results in a hint of an excess of EBL in the 0.18 - 0.62 $\mu$m range relative to the studied models, yet compatible with them within systematics., Comment: Accepted by MNRAS
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- 2019
179. MAGIC and Fermi-LAT gamma-ray results on unassociated HAWC sources
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Ahnen, M L, Ansoldi, S, Antonelli, L A, Arcaro, C, Baack, D, Babić, A, Banerjee, B, Bangale, P, Barres , de , Almeida, U, Barrio, J A, Becerra , González, J, Bednarek, W, Bernardini, E, Berse, R Ch, Berti, A, Bhattacharyya, W, Biland, A, Blanch, O, Bonnoli, G, Carosi, R, Carosi, A, Ceribella, G, Chatterjee, A, Colak, S M, Colin, P, Colombo, E, Contreras, J L, Cortina, J, Covino, S, Cumani, P, Da , Vela, P, Dazzi, F, De , Angelis, A, Lotto, B, Delfino, M, Delgado, J, Di , Pierro, F, Domínguez, A, Dominis , Prester, D, Dorner, D, Doro, M, Einecke, S, Elsaesser, D, Fallah , Ramazani, V, Fernández-Barral, A, Fidalgo, D, Fonseca, M V, Font, L, Fruck, C, Galindo, D, García , López, R J, Garczarczyk, M, Gaug, M, Giammaria, P, Godinović, N, Gora, D, Guberman, D, Hadasch, D, Hahn, A, Hassan, T, Hayashida, M, Herrera, J, Hose, J, Hrupec, D, Ishio, K, Konno, Y, Kubo, H, Kushida, J, Kuveždić, D, Lelas, D, Lindfors, E, Lombardi, S, Longo, F, López, M, Maggio, C, Majumdar, P, Makariev, M, Maneva, G, Manganaro, M, Mannheim, K, Maraschi, L, Mariotti, M, Martínez, M, Masuda, S, Mazin, D, Mielke, K, Minev, M, Miranda, J M, Mirzoyan, R, Moralejo, A, Moreno, V, Moretti, E, Nagayoshi, T, Neustroev, V, Niedzwiecki, A, Nievas , Rosillo, M, Nigro, C, Nilsson, K, Ninci, D, Nishijima, K, Noda, K, Nogués, L, Paiano, S, Palacio, J, Paneque, D, Paoletti, R, Paredes, J M, Pedaletti, G, Peresano, M, Persic, M, Prada , Moroni, P G, Prandini, E, Puljak, I, Garcia, J R, Reichardt, I, Rhode, W, Ribó, M, Rico, J, Righi, C, Rugliancich, A, Saito, T, Satalecka, K, Schweizer, T, Sitarek, J, Šnidarić, I, Sobczynska, D, Stamerra, A, Strzys, M, Surić, T, Takahashi, M, Takalo, L, Tavecchio, F, Temnikov, P, Terzić, T, Teshima, M, Torres-Albà, N, Treves, A, Tsujimoto, S, Vanzo, G, Vazquez , Acosta, M, Vovk, I, Ward, J E, Will, M, Zarić, D, Albert, A, Alfaro, R, Alvarez, C, Arceo, R, Arteaga-Velázquez, J C, Avila , Rojas, D, Ayala , Solares, H A, Becerril, A, Belmont-Moreno, E, Benzvi, S Y, Bernal, A, Braun, J, Caballero-Mora, K S, Capistrán, T, Carramiñana, A, Casanova, S, Castillo, M, Cotti, U, Cotzomi, J, Coutiño , León, S, León, C, la , Fuente, E, Diaz , Hernandez, R, Dichiara, S, Dingus, B L, Duvernois, M A, Díaz-Vélez, J C, Ellsworth, R W, Engel, K, Enriquez-Rivera, O, Fiorino, D W, Fleischhack, H, Fraija, N, García-González, J A, Garfias, F, González-Muñoz, A, González, M M, Goodman, J A, Hampel-Arias, Z, Harding, J P, Hernandez, S, Hueyotl-Zahuantitla, F, Hui, C M, Hüntemeyer, P, Iriarte, A, Jardin-Blicq, A, Joshi, V, Kaufmann, S, Lara, A, Lauer, R J, Lee, W H, Lennarz, D, León , Vargas, H, Linnemann, J T, Longinotti, A L, Luis-Raya, G, Luna-García, R, López-Coto, R, Malone, K, Marinelli, S S, Martinez, O, Martinez-Castellanos, I, Martínez-Castro, J, Martínez-Huerta, H, Matthews, J A, Miranda-Romagnoli, P, Moreno, E, Mostafá, M, Nayerhoda, A, Nellen, L, Newbold, M, Nisa, M U, Noriega-Papaqui, R, Pelayo, R, Pretz, J, Pérez-Pérez, E G, Ren, Z, Rho, C D, Rivière, C, Rosa-González, D, Rosenberg, M, Ruiz-Velasco, E, Salesa , Greus, F, Sandoval, A, Schneider, M, Seglar , Arroyo, M, Sinnis, G, Smith, A J, Springer, R W, Surajbali, P, Taboada, I, Tibolla, O, Tollefson, K, Torres, I, Ukwatta, T N, Vianello, G, Villaseñor, L, Werner, F, Westerhoff, S, Wood, J, Yapici, T, Yodh, G, Zepeda, A, Zhou, H, Álvarez, J D, Ajello, M, Baldini, L, Barbiellini, G, Berenji, B, Bissaldi, E, Blandford, R D, Bonino, R, Bottacini, E, Brandt, T J, Bregeon, J, Bruel, P, Cameron, R A, Caputo, R, Caraveo, P A, Castro, D, Cavazzuti, E, Chiaro, G, Ciprini, S, Costantin, D, D’Ammando, F, Palma, F, Desai, A, Lalla, N, Mauro, M, Venere, L, Favuzzi, C, Fukazawa, Y, Funk, S, Fusco, P, Gargano, F, Gasparrini, D, Giglietto, N, Giordano, F, Giroletti, M, Glanzman, T, Green, D, Grenier, I A, Guiriec, S, Harding, A K, Hays, E, Hewitt, J W, Horan, D, Jóhannesson, G, Kuss, M, Larsson, S, Liodakis, I, Loparco, F, Lubrano, P, Magill, J D, Maldera, S, Manfreda, A, Mazziotta, M N, Mereu, I, Michelson, P F, Mizuno, T, Monzani, M E, Morselli, A, Moskalenko, I V, Negro, M, Nuss, E, Omodei, N, Orienti, M, Orlando, E, Ormes, J F, Palatiello, M, Paliya, V S, Pesce-Rollins, M, Petrosian, V, Piron, F, Porter, T A, Principe, G, Rainò, S, Rani, B, Razzano, M, Razzaque, S, Reimer, A, Reimer, O, Sgrò, C, Siskind, E J, Spandre, G, Spinelli, P, Tajima, H, Thayer, J B, Thompson, D J, Torres, D F, Torresi, E, Troja, E, Valverde, J, Wood, K, Yassine, M, Fermi-LAT , Collaboration, Null, Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), MAGIC, HAWC, Fermi-LAT, ITA, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babic, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Berse, R. C., Berti, A., Bhattacharyya, W., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Carosi, A., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, Delgado, J., Di Pierro, F., Dominguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fernandez-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Garcia Lopez, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinovic, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuvedic, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, Francesco, Lopez, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Nagayoshi, T., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Strzys, M., Suric, T., Takahashi, M., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, Torres-Alba, N., Treves, A., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zaric, D., Albert, A., Alfaro, R., Alvarez, C., Arceo, R., Arteaga-Velazquez, J. C., Avila Rojas, D., Ayala Solares, H. A., Becerril, A., Belmont-Moreno, E., Benzvi, S. Y., Bernal, A., Braun, J., Caballero-Mora, K. S., Capistran, T., Carraminana, A., Casanova, S., Castillo, M., Cotti, U., Cotzomi, J., Coutino De Leon, S., De Leon, C., De La Fuente, E., Diaz Hernandez, R., Dichiara, S., Dingus, B. L., Duvernois, M. A., Diaz-Velez, J. C., Ellsworth, R. W., Engel, K., Enriquez-Rivera, O., Fiorino, D., Fleischhack, H., Fraija, N., Garcia-Gonzalez, J. A., Garfias, F., Gonzalez-Munoz, A., Gonzalez, M. M., Goodman, J. A., Hampel-Arias, Z., Harding, J. P., Hernandez, S., Hueyotl-Zahuantitla, F., Hui, C. M., Huntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kaufmann, S., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., Leon Vargas, H., Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Luna-Garcia, R., Lopez-Coto, Malone, K., Marinelli, S. S., Martinez, O., Martinez-Castellanos, I., Martinez-Castro, J., Martinez-Huerta, H., Matthews, J. A., Miranda-Romagnoli, P., Moreno, E., Mostafa, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Pelayo, R., Pretz, J., Perez-Perez, E. G., Ren, Z., Rho, C. D., Riviere, C., Rosa-Gonzalez, D., Rosenberg, M., Ruiz-Velasco, E., Salesa Greus, F., Sandoval, A., Schneider, M., Seglar Arroyo, M., Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Taboada, I., Tibolla, O., Tollefson, K., Torres, I., Ukwatta, T. N., Vianello, G., Villasenor, L., Werner, F., Westerhoff, S., Wood, J., Yapici, T., Yodh, G., Zepeda, A., Zhou, H., Alvarez, J. D., Ajello, M., Baldini, L., Barbiellini, G., Berenji, B., Bissaldi, E., Blandford, R. D., Bonino, R., Bottacini, Brandt, T. J., Bregeon, J., Bruel, P., Cameron, R. A., Caputo, R., Caraveo, P. A., Castro, D., Cavazzuti, E., Chiaro, G., Ciprini, Costantin, D., D'Ammando, De Palma, F., Desai, A., Di Lalla, N., Di Mauro, M., Di Venere, L., Favuzzi, C., Fukazawa, Y., Funk, S., Fusco, Gargano, F., Gasparrini, Giglietto, N., Giordano, Giroletti, M., Glanzman, T., Green, D., Grenier, I. A., Guiriec, S., Harding, A. K., Hays, E., Hewitt, J. W., Horan, D., Johannesson, Kuss, M., Larsson, Liodakis, I., Loparco, F., Lubrano, P., Magill, J. D., Maldera, S., Manfreda, A., Mazziotta, M. N., Mereu, I., Michelson, P. F., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Negro, M., Nuss, E., Omodei, N., Orienti, M., Orlando, E., Ormes, J. F., Palatiello, M., Paliya, V. S., Pesce-Rollins, M., Petrosian, V., Piron, F., Porter, T. A., Principe, G., Raino, S., Rani, B., Razzano, M., Razzaque, S., Reimer, A., Reimer, Sgro, C., Siskind, E. J., Spandre, G., Spinelli, Tajima, H., Thayer, J. B., Thompson, D. J., Torres, D. F., Torresi, E., Troja, E., Valverde, J., Wood, K., Yassine, Manal, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Longo, Yassine, Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
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Astrophysics::High Energy Astrophysical Phenomena ,pulsars: general – gamma rays: general – astroparticle physics ,FOS: Physical sciences ,Astrophysics ,general [pulsars] ,01 natural sciences ,VHE ,GLAST ,Pulsar ,Observatory ,pulsars: general ,0103 physical sciences ,MAGIC (telescope) ,010303 astronomy & astrophysics ,pulsar ,Astroparticle physics ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,gamma rays: general ,astroparticle physics ,010308 nuclear & particles physics ,Gamma ray ,astroparticle physic ,Astronomy and Astrophysics ,MAGIC ,observatory ,gamma ray: emission ,Space and Planetary Science ,Pulsars: general ,Física nuclear ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,general [gamma rays] ,HAWC ,Fermi Gamma-ray Space Telescope - Abstract
The HAWC Collaboration released the 2HWC catalog of TeV sources, in which 19 show no association with any known high-energy (HE; E > 10 GeV) or very-high-energy (VHE; E > 300 GeV) sources. This catalog motivated follow-up studies by both the MAGIC and Fermi-LAT observatories with the aim of investigating gamma-ray emission over a broad energy band. In this paper, we report the results from the first joint work between HAWC, MAGIC and Fermi-LAT on three unassociated HAWC sources: 2HWC J2006+341, 2HWC J1907+084* and 2HWC J1852+013*. Although no significant detection was found in the HE and VHE regimes, this investigation shows that a minimum 1 degree extension (at 95% confidence level) and harder spectrum in the GeV than the one extrapolated from HAWC results are required in the case of 2HWC J1852+013*, while a simply minimum extension of 0.16 degrees (at 95% confidence level) can already explain the scenario proposed by HAWC for the remaining sources. Moreover, the hypothesis that these sources are pulsar wind nebulae is also investigated in detail., 12 pages, 3 figures. Accepted for publication in MNRAS
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- 2019
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180. Patient-derived organoids from normal and tumoral colorectal tissue
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Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Burgos, Aurora, Barbáchano, Antonio, Muñoz Terol, Alberto, and Fernández-Barral, A.
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digestive system diseases - Abstract
Resumen del póster presentado al 42nd Congress of the Spanish Society of Biochemistry and Molecular Biology (SEBBM), celebrado en Madrid del 16 al 19 de julio de 2019., Colon and rectum are part of the same organ but have different embryological, anatomical and physiological characteristics. Although cancers from these two regions are often referred to as “colorectal cancer or CRC”, colon and rectal tumors differ in risk factors and mutational landscapes, which are analysed from complex heterotypic tumor biopsies. Accordingly, patients with colon or rectal tumors are managed differently in the clinic. Organoid technology allows the isolation and culture of normal and tumor stem cells, giving rise to structures that resemble functions and architecture of origin tissue or tumor. To gain further insight the transcriptomic and functional differences between colon and rectal cancers, we have generated two living biobank of 3D organoid cultures derived from human epithelial stem cells: a) the colon biobank from matched normal and tumor surgical samples of colon cancer patients; and b) a rectum biobank from endoscopy samples of normal rectum and rectal tumors, and when possible also from normal colon tissue, of rectal cancer patients. Endoscopy biopsies were obtained at diagnosis and so, they had never been exposed to radio- or chemotherapy. The study of functional behaviour and gene expression profiles of organoid cultures from colon and rectum will allow us to understand the possible differences between these two tissues in normal and tumoral conditions.
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- 2019
181. Teraelectronvolt emission from the γ-ray burst GRB 190114C
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MAGIC Collaboration, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Baack, D., Babić, A., Banerjee, B., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, A., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Gallozzi, S., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinović, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mićanović, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nöthe, M., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Peñil, P., Peresano, M., Persic, M., Moroni, P. G. Prada, Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tosti, L., Tsujimoto, S., Vagelli, V., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zarić, D., Nava, L., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), MAGIC, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbetengels, A., Baack, D., Babic, A., Banerjee, B., Barres deAlmeida, U., Barrio, J. A., Becerragonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, A., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., Deangelis, A., Delotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do SoutoEspineira, E., Dominisprester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallahramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Gallozzi, S., Garcialopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado deOliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Pradamoroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Tsujimoto, S., Vagelli, V., van Scherpenberg, J., Vanzo, G., Vazquezacosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., and Nava, L.
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electron ,Shock wave ,radiation: electromagnetic ,Stellar mass ,imaging cherenkov telescopes ,Astrophysics::High Energy Astrophysical Phenomena ,gamma-ray burst ,Synchrotron radiation ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,gamma ray: burst ,gamma-ray bursts ,GRB190114C ,01 natural sciences ,7. Clean energy ,Electromagnetic radiation ,photon: velocity ,X-ray ,TeV GRB ,synchrotron ,0103 physical sciences ,black hole ,ddc:530 ,neutron star ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,plasma ,Physics ,radio wave ,Multidisciplinary ,TeV GRB, GRB190114C, MAGIC ,synchrotron radiation ,010308 nuclear & particles physics ,shock waves: relativistic ,MAGIC ,Afterglow ,GRB 190114C ,inverse Compton radiation ,Automatic Keywords ,Neutron star ,Gamma Ray Burst ,efficiency ,13. Climate action ,star: mass ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Gamma-ray burst ,Radio wave - Abstract
International audience; Long-duration γ-ray bursts (GRBs) are the most luminous sources of electromagnetic radiation known in the Universe. They arise from outflows of plasma with velocities near the speed of light that are ejected by newly formed neutron stars or black holes (of stellar mass) at cosmological distances 1$^{,}$2 . Prompt flashes of megaelectronvolt-energy γ-rays are followed by a longer-lasting afterglow emission in a wide range of energies (from radio waves to gigaelectronvolt γ-rays), which originates from synchrotron radiation generated by energetic electrons in the accompanying shock waves 3$^{,}$4 . Although emission of γ-rays at even higher (teraelectronvolt) energies by other radiation mechanisms has been theoretically predicted 5$^{–}$8 , it has not been previously detected 7$^{,}$8 . Here we report observations of teraelectronvolt emission from the γ-ray burst GRB 190114C. γ-rays were observed in the energy range 0.2–1 teraelectronvolt from about one minute after the burst (at more than 50 standard deviations in the first 20 minutes), revealing a distinct emission component of the afterglow with power comparable to that of the synchrotron component. The observed similarity in the radiated power and temporal behaviour of the teraelectronvolt and X-ray bands points to processes such as inverse Compton upscattering as the mechanism of the teraelectronvolt emission 9$^{–}$11 . By contrast, processes such as synchrotron emission by ultrahigh-energy protons 10$^{,}$12$^{,}$13 are not favoured because of their low radiative efficiency. These results are anticipated to be a step towards a deeper understanding of the physics of GRBs and relativistic shock waves.
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- 2019
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182. Statistics of VHE gamma-Rays in Temporal Association with Radio Giant Pulses from the Crab Pulsar
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J. Palacio, J. M. Paredes, Antonio Stamerra, L. Maraschi, Elina Lindfors, Daniel Mazin, Chiara Righi, Wlodek Bednarek, Alessandro Carosi, P. Temnikov, Pratik Majumdar, N. Torres-Albà, M. V. Fonseca, S. N. Shore, Martin Will, Jose Miguel Miranda, E. Colombo, E. Prandini, Aaron Dominguez, Kari Nilsson, L. O. Takalo, Francesco Longo, Juan Abel Barrio, Masahiro Teshima, Nikola Godinovic, U. Menzel, L. A. Antonelli, Mosè Mariotti, D. Hadasch, J. E. Ward, Alba Fernández-Barral, M. Engelkemeier, Stefano Covino, Martin Makariev, Alexander Hahn, P. Colin, Saverio Lombardi, Andrea Rugliancich, Sidika Merve Colak, Oscar Blanch, Arka Chatterjee, Adrian Biland, Christian Fruck, Tomoki Saito, M. Doert, T. Surić, Shimpei Tsujimoto, M. Garczarczyk, Ana Babić, D. Fidalgo, M. Peresano, Camilla Maggio, J. Rico, S. Schroeder, Ivica Puljak, Ievgen Vovk, M. Vazquez Acosta, D. Dominis Prester, Tarek M. Hassan, B. Biasuzzi, Victoria Moreno, Fabrizio Tavecchio, L. Nogués, E. Moretti, D. Kuveždić, Jose Luis Contreras, Abelardo Moralejo, F. Di Pierro, Yusuke Konno, Juan Cortina, T. Schweizer, J. R. Garcia, Giacomo Bonnoli, A. De Angelis, A. Treves, Vitaly Neustroev, V. Fallah Ramazani, Max Ludwig Ahnen, Wrijupan Bhattacharyya, T. Nagayoshi, Daniela Dorner, Dariusz Gora, Gaia Vanzo, G. Maneva, Junko Kushida, P. Da Vela, Kyoshi Nishijima, U. Barres de Almeida, M. Minev, I. Reichardt, P. Giammaria, A. Niedzwiecki, R. Smits, M. Gaug, Damir Lelas, D. Elsaesser, I. Snidaric, Dorota Sobczyńska, J. Herrera, B. De Lotto, Julian Sitarek, Koji Noda, J. Hose, Elisa Bernardini, Stefano Ansoldi, David Paneque, M. I. Martínez, Riccardo Paoletti, D. Guberman, Marina Manganaro, Sabrina Einecke, D. Galindo, P. Cumani, Konstancja Satalecka, Michele Doro, Dario Hrupec, M. A. Lopez, S. Paiano, Karl Mannheim, P. G. Prada Moroni, Tomislav Terzić, Francesco Dazzi, J. Becerra González, Alessio Berti, Natalia Lewandowska, L. Perri, D. Eisenacher Glawion, Cosimo Nigro, M. Nievas Rosillo, B. Banerjee, C. Arcaro, Lluis Font, Marcel Strzys, R. J. García López, G. Pedaletti, Massimo Persic, Wolfgang Rhode, D. Ninci, M. Hayashida, D. Zarić, Marc Ribó, P. Bangale, Hidetoshi Kubo, R. Mirzoyan, Kazuma Ishio, Rodolfo Carosi, German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Universidad de Barcelona, Croatian Science Foundation, University of Rijeka, Foundation for Polish Science, Ministério da Ciência, Tecnologia e Inovação (Brasil), Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Babic, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Berti, A., Bhattacharyya, W., Biasuzzi, B., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Carosi, A., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Di Pierro, F., Doert, M., Dominguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher Glawion, D., Elsaesser, D., Engelkemeier, M., Fallah Ramazani, V., Fernandez-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Garcia Lopez, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinovic, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuvez Dic, D., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Menzel, U., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Nagayoshi, T., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Shore, S. N., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Strzys, M., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Treves, A., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zaric, D., and Smits, R.
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Photon ,Radiation mechanisms: non-thermal ,Radio continuum: stars ,VHE [gamma ray] ,Astrophysics ,01 natural sciences ,Cherenkov ,individual ,010303 astronomy & astrophysics ,Pulsars: individual: Crab pulsar ,pulsar ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,photon ,Gamma ray ,Astrophysics::Instrumentation and Methods for Astrophysics ,imaging ,pulsed ,Gamma rays: stars ,pulsars: individual: Crab pulsar - gamma-rays: stars - radio continuum: stars - radiation mechanics: non-thermal ,detector [radio wave] ,statistics ,Crab pulsar ,Global Positioning System ,stars [Radio continuum] ,Física nuclear ,Astrophysics - High Energy Astrophysical Phenomena ,stars ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,pulsars ,gamma rays ,radio continuum ,radiation mechanisms ,non-thermal ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Radio telescope ,star [Gamma rays] ,Pulsar ,emission [gamma ray] ,0103 physical sciences ,010306 general physics ,enhancement ,Astrophysics::Galaxy Astrophysics ,Cherenkov radiation ,non-thermal [Radiation mechanisms] ,business.industry ,Crab Pulsar ,stars [Gamma rays] ,Astronomy and Astrophysics ,individual: Crab pulsar [Pulsars] ,MAGIC ,flux ,Stars ,Space and Planetary Science ,correlation ,ddc:520 ,business ,statistical - Abstract
[Aims] The aim of this study is to search for evidence of a common emission engine between radio giant pulses (GPs) and very-high-energy (VHE, E > 100 GeV) γ-rays from the Crab pulsar., [Methods] We performed 16 h of simultaneous observations of the Crab pulsar at 1.4 GHz with the Effelsberg radio telescope and the Westerbork Synthesis Radio Telescope (WSRT), and at energies above 60 GeV we used the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes. We searched for a statistical correlation between the radio and VHE γ-ray emission with search windows of different lengths and different time lags to the arrival times of a radio GP. A dedicated search for an enhancement in the number of VHE γ-rays correlated with the occurrence of radio GPs was carried out separately for the P1 and P2 phase ranges, respectively., [Results] In the radio data sample, 99444 radio GPs were detected. We find no significant correlation between the GPs and VHE photons in any of the search windows. Depending on phase cuts and the chosen search windows, we find upper limits at a 95% confidence level on an increase in VHE γ-ray events correlated with radio GPs between 7% and 61% of the average Crab pulsar VHE flux for the P1 and P2 phase ranges, respectively. This puts upper limits on the flux increase during a radio GP between 12% and 2900% of the pulsed VHE flux, depending on the search window duration and phase cuts. This is the most stringent upper limit on a correlation between γ-ray emission and radio GPs reported so far., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, CSD2009-00064), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2012-0234 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project 09/176 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ.
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183. New experimental murine models for colorectal cancer
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López-Briones, T., Ortega-Rodríguez, J., Cámara, Ana Belén, Fernández-Barral, A., Bustamante-Madrid, Pilar, Costales-Carrera, Alba, Zarich, Natasha, Oliva, José Luis, Barbáchano, Antonio, Muñoz Terol, Alberto, Anta, B., Rojas-Cabañeros, José M., and Lucas, M. P. de
- Abstract
Trabajo presentado en el XVIII Congreso de la Sociedad Española de Biología Celular (SEBC), celebrado en Badajoz (España) del 15 al 18 de octubre de 2019., Colorectal cancer (CRC) has the highest incidence rate in the Spanish population, and the third one worldwide. The most important challenge consists on the discovery of efficient disease treatments, due to high mortality rates in highly developed stages. Although the genetic mutations that lead to CRC are well established, directed therapies are not fully successful. For this reason, some researchers are seeking for new therapeutic targets that can address alternative approaches. In this way, our group has developed several animal models that can recapitulate CRC and offer different approaches to validate potential new targets. Our conditional inducible genetic murine models allow to study this disease at several stages (like tumor initiation or malignancy progression) and, more importantly, to evaluate the therapeutic potential of new strategies/therapies and targets on them. On the other hand, development of specific protocols with these experimental models also enable to study mutational changes and pathway deregulations associated with CRC, in order to better understand the biology of the disease. In this session we will highlight innovative proceedings that can be used with animal models to further combat CRC.
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- 2019
184. Deep observations of the globular cluster M15 with the MAGIC telescopes
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B. Machado de Oliveira Fraga, A. Lamastra, Jordi Delgado, P. Giammaria, Razmik Mirzoyan, D. Baack, D. Galindo, Massimo Persic, John Hoang, E. Moretti, J. Palacio, Pablo Peñil, Chiara Righi, A. Hahn, R. J. García López, Kari Nilsson, P. Majumdar, J. M. Paredes, Antonio Stamerra, J. Becerra González, Dorota Sobczyńska, Francesco Longo, Satoshi Masuda, D. Dominis Prester, Adrian Biland, S. Gasparyan, Y. Iwamura, M. Strzys, J. Kushida, S. M. Colak, Abelardo Moralejo, Jose Luis Contreras, Juan Cortina, A. Fernández-Barral, N. Godinović, Takashi Saito, Pierre Colin, Tihomir Surić, Francesco Leone, W. Rhode, M. V. Fonseca, I. Puljak, P G Prada Moroni, N. Sahakyan, W. Bhattacharyya, V. Fallah Ramazani, J. Rico, P. Munar-Adrover, Oscar Blanch, A. Somero, Saverio Lombardi, Louis Antonelli, U. Barres de Almeida, A. Niedzwiecki, D. Fidalgo, M. Will, David H. Green, Edgar Molina, V. D'Elia, E. Colombo, S. Gallozzi, A. De Angelis, G. Vanzo, Petar Temnikov, Koji Noda, Ana Babić, Stefan Cikota, A. Fattorini, D. Ninci, Shimpei Tsujimoto, M. I. Martínez, M. Vazquez Acosta, Stefano Ansoldi, Elisa Bernardini, Masahiro Teshima, M. Peresano, Giovanni Busetto, M. Mallamaci, F. Di Pierro, Lab Saha, B. De Lotto, D. Dorner, Markus Gaug, M. López, Elisa Prandini, A. Arbet Engels, D. Hadasch, Sabrina Einecke, Victoria Moreno, D. Kuveždić, Julian Sitarek, Rodolfo Carosi, D. Lelas, Vitaly Neustroev, Francesco Dazzi, Darko Zarić, Jürgen Besenrieder, K. Mannheim, Juan Abel Barrio, D. Elsaesser, I. Vovk, M. Makariev, Ciro Bigongiari, Aaron Dominguez, M. Nöthe, S. Paiano, B. Banerjee, K. Ishio, C. Nigro, G. Ceribella, G. Pedaletti, W. Bednarek, C. Maggio, G. Maneva, E. Do Souto Espiñera, Fabrizio Tavecchio, Ll. Font, Tomislav Terzić, Susumu Inoue, M. Nievas Rosillo, Dario Hrupec, R. Paoletti, A. López-Oramas, L. Foffano, L. Maraschi, M. Delfino, Marc Ribó, Jose Carlos Herrera, Elina Lindfors, Daniel Mazin, A. Berti, J. R. Garcia, Stefano Covino, M. Minev, Hidetoshi Kubo, G. Bonnoli, T. Schweizer, L. Nogués, M. Mariotti, M. Garczarczyk, V. A. Acciari, J. van Scherpenberg, K. Nishijima, P. Da Vela, Iva Šnidarić, A. Rugliancich, Marina Manganaro, G. Ferrara, D. Paneque, Konstancja Satalecka, Michele Doro, C. Fruck, D. Guberman, N. Torres-Albà, Jose Miguel Miranda, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Busetto, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Do Souto Espinera, E., Dominguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giammaria, P., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuvezdic, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Oramas, A., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Suric, T., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., and Zaric, D.
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Radiation mechanisms: non-thermal ,Astrophysics::High Energy Astrophysical Phenomena ,Population ,general [Pulsars] ,Globular clusters: general ,FOS: Physical sciences ,astro-ph.HE ,Astrophysics ,01 natural sciences ,7. Clean energy ,stars [gamma-rays] ,Pulsar ,Millisecond pulsar ,0103 physical sciences ,Gamma-rays: stars ,Globular clusters: individual: M15 ,Pulsars: general ,Astronomy and Astrophysics ,Space and Planetary Science ,Astrophysics::Solar and Stellar Astrophysics ,star [Gamma-rays] ,education ,010303 astronomy & astrophysics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,education.field_of_study ,individual: M15 [Globular clusters] ,non-thermal [Radiation mechanisms] ,010308 nuclear & particles physics ,Compton scattering ,Stars ,Crab Nebula ,Globular cluster ,ddc:520 ,High Energy Physics::Experiment ,Electrónica ,general [Globular clusters] ,radiation mechanisms: non-thermal ,pulsars: general ,globular clusters: general ,globular clusters: individual: M15 ,gamma-rays: stars ,Electricidad ,Astrophysics - High Energy Astrophysical Phenomena ,Lepton - Abstract
A population of globular clusters (GCs) has been recently established by the Fermi-LAT telescope as a new class of GeV $\gamma$-ray sources. Leptons accelerated to TeV energies, in the inner magnetospheres of MSPs or in their wind regions, should produce $\gamma$-rays through the inverse Compton scattering in the dense radiation field from the huge population of stars. We have conducted deep observations of the globular cluster M15 with the MAGIC telescopes and used 165 hrs in order to search for $\gamma$-ray emission. A strong upper limit on the TeV $\gamma$-ray flux $, Comment: 11 pages, 7 figures, accepted for publication in MNRAS
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185. A fast, very-high-energy gamma-ray flare from BL Lacertae during a period of multi-wavelength activity in June 2015
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MAGIC Collaboration, Acciari, V. A., Ansoldi, S., ANTONELLI, Lucio Angelo, Arbet Engels, A., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres de Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., BIGONGIARI, Ciro, Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., COVINO, Stefano, D'Elia, V., da Vela, P., Dazzi, F., de Angelis, A., de Lotto, B., Delfino, M., Delgado, J., di Pierro, F., Do Souto Espiñera, E., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., GALLOZZI, Stefano, García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuveždić, D., LAMASTRA, Alessandra, Lelas, D., LEONE, FRANCESCO, Lindfors, E., LOMBARDI, Saverio, Longo, F., López, M., López-Oramas, A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nöthe, M., PAIANO, Simona, Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., PERSIC, Massimo, Prada Moroni, P. G., PRANDINI, ELISA, Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, Chiara, Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., STAMERRA, Antonio, Strzys, M., Surić, T., TAVECCHIO, Fabrizio, Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., Zarić, D., D'AMMANDO, FILIPPO, Hada, K., Jorstad, S., Marscher, A. P., Mobeen, M. Z., Hovatta, T., Larionov, V. M., Borman, G. A., Grishina, T. S., Kopatskaya, E. N., Morozova, D. A., Nikiforova, A. A., Lähteenmäki, A., Tornikoski, M., Agudo, I., ITA, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Do Souto Espinera, E., Dominguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., Garcia Lopez, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinovic, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuvezdic, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Oramas, A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Suric, T., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., Zaric, D., D'Ammando, F., Hada, K., Jorstad, S., Marscher, A. P., Mobeen, M. Z., Hovatta, T., Larionov, V. M., Borman, G. A., Grishina, T. S., Kopatskaya, E. N., Morozova, D. A., Nikiforova, A. A., Lahteenmaki, A., Tornikoski, M., Agudo, I., Istituto Nazionale di Fisica Nucleare, Department of Atomic Energy (India), Japanese Government, Croatian Science Foundation, University of Rijeka, German Research Foundation, Polish Academy of Sciences, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministry of Science and Technology (South Korea), Junta de Andalucía, Russian Science Foundation, National Science Foundation (US), National Aeronautics and Space Administration (US), Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Federal Ministry of Education and Research (Germany), Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
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galaxies [Gamma rays] ,Photon ,model [emission] ,VHE [gamma ray] ,Inverse ,Astrophysics ,4/3 ,BL Lacertae objects: individual: BL Lacertae ,01 natural sciences ,7. Clean energy ,rotation ,law.invention ,star ,law ,jet ,Gamma rays: galaxies ,010303 astronomy & astrophysics ,Physics ,astro-ph.HE ,radio wave ,model [interaction] ,photon ,Gamma ray ,Optical polarization ,tension ,3. Good health ,optical [polarization] ,Spectral energy distribution ,high [energy] ,Física nuclear ,Astrophysics - High Energy Astrophysical Phenomena ,Flare ,Active galactic nucleus ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Cosmology and Extragalactic Astrophysics ,gamma rays: galaxies ,X-ray ,0103 physical sciences ,AGN ,individual: BL Lacertae [BL Lacertae objects] ,010308 nuclear & particles physics ,Astronomy and Astrophysics ,Light curve ,MAGIC ,flux ,Space and Planetary Science ,ddc:520 ,spectral - Abstract
The mechanisms producing fast variability of the γ-ray emission in active galactic nuclei (AGNs) are under debate. The MAGIC telescopes detected a fast, very-high-energy (VHE, E > 100 GeV) γ-ray flare from BL Lacertae on 2015 June 15. The flare had a maximum flux of (1.5 ± 0.3) × 10-10 photons cm-2 s-1 and halving time of 26 ± 8 min. The MAGIC observations were triggered by a high state in the optical and high-energy (HE, E > 100 MeV) γ-ray bands. In this paper we present the MAGIC VHE γ-ray data together with multi-wavelength data from radio, optical, X-rays, and HE γ rays from 2015 May 1 to July 31. Well-sampled multi-wavelength data allow us to study the variability in detail and compare it to the other epochs when fast, VHE γ-ray flares have been detected from this source. Interestingly, we find that the behaviour in radio, optical, X-rays, and HE γ-rays is very similar to two other observed VHE γ-ray flares. In particular, also during this flare there was an indication of rotation of the optical polarization angle and of activity at the 43 GHz core. These repeating patterns indicate a connection between the three events. We also test modelling of the spectral energy distribution based on constraints from the light curves and VLBA observations, with two different geometrical setups of two-zone inverse Compton models. In addition we model the γ-ray data with the star-jet interaction model. We find that all of the tested emission models are compatible with the fast VHE γ-ray flare, but all have some tension with the multi-wavelength observations. © ESO 2019., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA 2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA201569210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662C2-2-P, FPA201790566REDC), the Indian Department of Atomic Energy and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia >Severo Ochoa> SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia >Maria de Maeztu> MDM-20140369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ. The work of the author M. Vazquez Acosta is financed with grant RYC-2013-14660 of MINECO. F. D'Ammando is grateful for support from the National Research Council of Science and Technology, Korea (EU16-001). The Fermi-LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat a l'Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucleaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d'Etudes Spatiales in France. This work performed in part under DOE Contract DE-AC02-76SF00515. Based on observations made with the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias., Acquisition and reduction of the MAPCAT data was supported in part by MINECO through grants AYA201014844, AYA2013-40825-P, and AYA2016-80889-P, and by the Regional Government of Andalucia through grant P09-FQM-4784. The MAPCAT observations were carried out at the German-Spanish Calar Alto Observatory, which is jointly operated by the Max-Plank-Institut fur Astronomie and the Instituto de Astrofisica de Andalucia-CSIC. The St. Petersburg University team acknowledges support from Russian Science Foundation grant 17-12-01029. This publication makes use of data obtained at the Metsahovi Radio Observatory, operated by Aalto University, Finland. This study makes use of 43-GHz VLBA data from the VLBA-BU Blazar Monitoring Program (VLBA-BUBLAZAR; http://www.bu.edu/blazars/VLBAproject.html), funded by NASA through the Fermi Guest Investigator Program. The VLBA is an instrument of the National Radio Astronomy Observatory. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated by Associated Universities, Inc. The BU group acknowledges support from NASA Fermi GI program grant 80NSSC17K0694 and US National Science Foundation grant AST-1615796. The OVRO 40-m monitoring program is supported in part by NASA grants NNX08AW31G, NNX11A043G and NNX14AQ89G, and NSF grants AST-0808050 and AST-1109911.
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- 2019
186. Mobility of iron oxide nanoparticles in an extracellular matrix and their internalization in patient-derived colorectal cancer organoids for magnetic hyperthermia treatments
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Morales, I., Fernández-Barral, A., Costales-Carrera, Alba, Barbáchano, Antonio, Márquez M. A., Morales, M. P., Hernando, Antonio, Muñoz Terol, Alberto, and Presa, Patricia de la
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Trabajo presentado en "Spanish Conference on Biomedical Applications of Nanomaterials", celebrada en Madrid (España) del 6 al 7 de junio de 2019., In this study, we investigate the uptake of magnetic nanoparticles in colon cancer cells grown in 3D in order to optimize the magnetic hyperthermia performance. Most of the studies related to cellular uptake have been reported in 2D cells grown in monolayers on a Petri dish, and it is necessary to study a more realistic cell culture system that may resemble the in vivo conditions. For that purpose, human colon cancer cells were embedded in a matrix (Matrigel) that allows them grow in 3D. These structures are called organoids, and they are able to acquire the architecture and function of origin tissue. First of all, we studied the interaction of iron oxide nanoparticles with the extracellular medium. The permeability of Matrigel was investigated by putting nanoparticles on Matrigel’s surface and analysing their diffusion and the temporal evolution of the depth of the colloid by means of a phase-contrast microscope. Once the Matrigel barrier had been crossed, the internalization of nanoparticles with different coatings was investigated under a confocal microscope. The internalization is discussed as a function of sizes and aggregation degree.
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- 2019
187. Colon cancer stem cells: organoids and target of therapeutic intervention
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Barbáchano, Antonio, Fernández-Barral, A., Costales-Carrera, Alba, Bustamante-Madrid, Pilar, and Muñoz Terol, Alberto
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Trabajo presentado en el XVIII Congreso de la Sociedad Española de Biología Celular, celebrado en Badajoz (España) del 15 al 18 de octubre de 2019., In 2007, Hans Clevers' group identified a stem cell population in the gut that was able to renew the entire intestinal epithelium every few days. These cells expressed LgrS, a plasma membrane protein (Lgrs+ cells). Subsequent research led to demonstrate in mice that cancer stem cells (CSC) are the origin of cancer. Clevers's group also developed a new 3D culture technology to indefinitely grow this population of intestinal Lgrs+ stem cells and their progeny first from mouse intestine and later from human intestine. These cultures give rise to miniaturized complex structures that resemble the organ they derived from and were called organoids or mini-guts. An enormous work done in this field has allowed to obtain organoids from multiple organs (liver, pancreas, bladder, breast, lung, prostate...) of different species. Organoids reflect the genetic background, cellular heterogeneity and the structure and functionality of their tissue of origin, are genetically stable and can be obtained from a simple biopsy from patient-derived healthy and diseased tissues. Organoid models are now becoming a promising tool far medical research, disease modelling, drug development, personalized treatment and regenerative medicine, and constitute an alternative far animal models. Recent studies have demonstrated the presence of Lgrs+ stem cells populations in both tumors and organoids of human and mouse origin. They are considered as both the tumor initiating cells and the cell population responsable far tumor relapse after chemotherapeutic treatments. However, the existence of additional stem cell types in the gut r4 cells, Dlll+s cells) and the large plasticity of intestinal cells have obscured the possible therapeutic value of therapies directed against LGRs+ ese. We have established a living biobank of organoids from healthy and tumor colon tissue of 39 colon cancer patients. By means of global transcriptomic studies (RNA-sequencing and chromatin immunoprecipitation-sequencing), we have analyzed and compared the gene expression profiles of human colon normal and tumor organoids and their response to calcitriol, the active vitamin D metabolite, proposed to protect against colon cancer. Our data indicate that calcitriol contributes to maintain the stemness of normal colon stem cells while it induces cell differentiation in tumor colon organoids (Fernández-Barral et al., FEBS J., 2019). Thus, our results favor a protective effect of vitamin D acting over CSC.
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- 2019
188. Differential effects of vitamin D in colorectal patient-derived normal and tumor organoids
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Fernández-Barral, A., Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Muñoz Terol, Alberto, and Barbáchano, Antonio
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Trabajo presentado en el European Organoids Symposium, celebrado en Milán (Italia) del 23 al 24 de septiembre de 2019.
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- 2019
189. A Fast Very High Energy $\gamma$-ray Flare from BL Lacertae during a Period of Multiwavelength activity in June 2015
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Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Espiñera, E. Souto, Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., López, R. J. García, Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuveždić, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Oramas, A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nöthe, M., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., Zarić, D., D'Ammando, F., Hada, K., Jorstad, S., Marscher, A. P., Mobeen, M. Z., Larionov, V. M., Borman, G. A., Grishina, T. S., Kopatskaya, E. N., Morozova, D. A., Nikiforova, A. A., Lähteenmäki, A., Tornikoski, M., Agudo, I., and MAGIC Collaboration
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energy: high ,radio wave ,interaction: model ,photon ,tension ,4/3 ,MAGIC ,rotation ,emission: model ,X-ray ,flux ,gamma ray: VHE ,star ,jet ,spectral ,polarization: optical ,AGN - Abstract
Astronomy and astrophysics 623, A175 - (2019). doi:10.1051/0004-6361/201834010, The mechanisms producing fast variability of the γ-ray emission in active galactic nuclei (AGNs) are under debate. The MAGIC telescopes detected a fast, very-high-energy (VHE, E > 100 GeV) γ-ray flare from BL Lacertae on 2015 June 15. The flare had a maximum flux of (1.5 ± 0.3) × 10−10 photons cm−2 s−1 and halving time of 26 ± 8 min. The MAGIC observations were triggered by a high state in the optical and high-energy (HE, E > 100 MeV) γ-ray bands. In this paper we present the MAGIC VHE γ-ray data together with multi-wavelength data from radio, optical, X-rays, and HE γ rays from 2015 May 1 to July 31. Well-sampled multi-wavelength data allow us to study the variability in detail and compare it to the other epochs when fast, VHE γ-ray flares have been detected from this source. Interestingly, we find that the behaviour in radio, optical, X-rays, and HE γ-rays is very similar to two other observed VHE γ-ray flares. In particular, also during this flare there was an indication of rotation of the optical polarization angle and of activity at the 43 GHz core. These repeating patterns indicate a connection between the three events. We also test modelling of the spectral energy distribution based on constraints from the light curves and VLBA observations, with two different geometrical setups of two-zone inverse Compton models. In addition we model the γ-ray data with the star-jet interaction model. We find that all of the tested emission models are compatible with the fast VHE γ-ray flare, but all have some tension with the multi-wavelength observations.Key words: BL Lacertae objects: individual: BL Lacertae / gamma rays: galaxies⋆ MAGIC and multiwavelength data are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/623/A175⋆⋆ Corresponding authors: E. Lindfors, e-mail: elilin@utu.fi; M. Vazquez Acosta, e-mail: monicava@iac.es; S. Tsujimoto, e-mail: shimpei.tsujimoto@gmail.com, Published by EDP Sciences, Les Ulis
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- 2019
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190. Differential effects of vitamin D in colorectal patient-derived normal and tumor organoids
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Fernández-Barral, Asunción, Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Muñoz Terol, Alberto, Barbáchano, Antonio, Fernández-Barral, Asunción, Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Muñoz Terol, Alberto, and Barbáchano, Antonio
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- 2019
191. P-40 Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
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Viñal, D., Martinez-Recio, S., Ruiz, I., Jimenez-Bou, D., Peña, J., Martin-Montalvo, G., Rueda-Lara, A., Alameda, M., Prieto, I., Muñoz, A., Rodriguez-Cobos, J., Bustamante, P., Larriba, M., Ghanem, I., Fernandez-Barral, A., Feliu, J., Barbachano, A., Gonzalez-Sancho, J., Burgos, A., G-Pastrián, L., and Rodríguez-Salas, N.
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- 2022
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192. Constraining Lorentz invariance violation using the Crab Pulsar emission observed up to TeV energies by MAGIC
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Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Babić, A., Banerjee, B., Bangale, P., De Almeida, U. Barres, Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, A., Bhattacharyya, W., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Carosi, R., Carosi, A., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Oña Wilhelmi, E., Di Pierro, F., Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Engelkemeier, M., Ramazani, V. Fallah, Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Garrido, D., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Inada, T., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Minev, M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Moroni, P. G. Prada, Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Shore, S. N., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Torres, D. F., Torres-Albà, N., Treves, A., Vanzo, G., Acosta, M. Vazquez, Vovk, I., Ward, J. E., Will, M., Zarić, D., Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Babić, A., Banerjee, B., Bangale, P., De Almeida, U. Barre, Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, A., Bhattacharyya, W., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Carosi, R., Carosi, A., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Oña Wilhelmi, E., Di Pierro, F., Doert, M., Domínguez, A., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Engelkemeier, M., Ramazani, V. Fallah, Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Garrido, D., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Inada, T., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Minev, M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Moroni, P. G. Prada, Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Shore, S. N., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Torres, D. F., Torres-Albà, N., Treves, A., Vanzo, G., Acosta, M. Vazquez, Vovk, I., Ward, J. E., Will, M., and Zarić, D.
- Subjects
Particle physics ,Active galactic nucleus ,Astrophysics::High Energy Astrophysical Phenomena ,statistical [methods] ,cosmic rays ,gamma rays: general ,gravitation ,methods: data analysis ,methods: statistical ,pulsars: individual (Crab Pulsar) ,individual (Crab Pulsar) [pulsars] ,FOS: Physical sciences ,Lorentz covariance ,01 natural sciences ,symbols.namesake ,Pulsar ,0103 physical sciences ,010303 astronomy & astrophysics ,cosmic ray ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Planck energy ,Superluminal motion ,010308 nuclear & particles physics ,Crab Pulsar ,Order (ring theory) ,Astronomy and Astrophysics ,Astronomy and Astrophysic ,Space and Planetary Science ,data analysi [methods] ,symbols ,ddc:520 ,Electrónica ,Física nuclear ,Electricidad ,Astrophysics - High Energy Astrophysical Phenomena ,general [gamma rays] ,Energy (signal processing) - Abstract
The astrophysical journal / Supplement series 232(1), 9 (2017). doi:10.3847/1538-4365/aa8404, Spontaneous breaking of Lorentz symmetry at energies on the order of the Planck energy or lower is predicted by many quantum gravity theories, implying non-trivial dispersion relations for the photon in vacuum. Consequently, gamma-rays of different energies, emitted simultaneously from astrophysical sources, could accumulate measurable differences in their time of flight until they reach the Earth. Such tests have been carried out in the past using fast variations of gamma-ray flux from pulsars, and more recently from active galactic nuclei and gamma-ray bursts. We present new constraints studying the gamma-ray emission of the galactic Crab Pulsar, recently observed up to TeV energies by the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) collaboration. A profile likelihood analysis of pulsar events reconstructed for energies above 400 GeV finds no significant variation in arrival time as their energy increases. Ninety-five percent CL limits are obtained on the effective Lorentz invariance violating energy scale at the level of ${E}_{{\mathrm{QG}}_{1}}\gt 5.5\times {10}^{17}\,\mathrm{GeV}$ ($4.5\times {10}^{17}\,\mathrm{GeV}$) for a linear, and ${E}_{{\mathrm{QG}}_{2}}\gt 5.9\times {10}^{10}\,\mathrm{GeV}$ ($5.3\times {10}^{10}\,\mathrm{GeV}$) for a quadratic scenario, for the subluminal and the superluminal cases, respectively. A substantial part of this study is dedicated to calibration of the test statistic, with respect to bias and coverage properties. Moreover, the limits take into account systematic uncertainties, which are found to worsen the statistical limits by about 36%–42%. Our constraints would have been much more stringent if the intrinsic pulse shape of the pulsar between 200 GeV and 400 GeV was understood in sufficient detail and allowed inclusion of events well below 400 GeV., Published by Univ. of Chicago Press11033, Chicago, Ill. [u.a.]
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- 2017
193. Observation of the black widow B1957+20 millisecond pulsar binary system with the MAGIC telescopes
- Author
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M. I. Martínez, Sabrina Einecke, G. Pedaletti, S. R. Gozzini, Thomas Bretz, L. Nogués, E. Moretti, J. Becerra González, Giacomo Bonnoli, F. Di Pierro, M. Engelkemeier, E. Prandini, Francesco Longo, I. Snidaric, Stefano Covino, B. De Lotto, Alessio Berti, S. Bonnefoy, A. Sillanpää, Arka Chatterjee, M. Vazquez Acosta, Ana Babić, Wolfgang Rhode, Alexander Hahn, Nikola Godinovic, Gareth Hughes, B. Biasuzzi, U. Barres de Almeida, D. Elsaesser, Juan Abel Barrio, R. Mirzoyan, Damir Lelas, Victoria Moreno, Tomoki Saito, D. Tescaro, Dario Hrupec, L. Perri, A. De Angelis, A. Treves, Vitaly Neustroev, Stefano Ansoldi, P. Da Vela, M. A. Lopez, Kari Nilsson, D. Dominis Prester, Riccardo Paoletti, Daniela Dorner, S. Griffiths, Dorota Sobczyńska, Dariusz Gora, J. Palacio, M. Will, D. Eisenacher Glawion, Abelardo Moralejo, Gaia Vanzo, Marcel Strzys, X. Paredes-Fortuny, Mosè Mariotti, M. Nievas Rosillo, J. M. Paredes, Antonio Stamerra, Yusuke Konno, S. Schroeder, Ivica Puljak, Pierre Colin, M. Gaug, Tomislav Terzić, L. Maraschi, V. Fallah Ramazani, J. Kushida, Martin Makariev, Elina Lindfors, Jose Luis Contreras, Oscar Blanch, Saverio Lombardi, Christian Fruck, Daniel Mazin, B. Banerjee, C. Arcaro, G. Maneva, Juan Cortina, E. de Oña Wilhelmi, S. Paiano, Kazuma Ishio, Karl Mannheim, J. Herrera, M. Doert, E. Colombo, Adrian Biland, M. H. Wu, L. A. Antonelli, J. R. Garcia, Lucas Guillemot, L. O. Takalo, Koji Noda, Aaron Dominguez, F. Borracci, Elisa Bernardini, J. Rico, Pratik Majumdar, M. V. Fonseca, T. Surić, Masahiro Teshima, Tarek M. Hassan, R. J. García López, J. E. Ward, Fabrizio Tavecchio, Ismaël Cognard, Rodolfo Carosi, Ll. Font, Wlodek Bednarek, Alessandro Carosi, D. Kuveždić, N. Torres-Albà, Max Ludwig Ahnen, I. Reichardt, P. Temnikov, P. Giammaria, Massimo Persic, U. Menzel, Diego F. Torres, M. Garczarczyk, Ievgen Vovk, M. Peresano, T. Schweizer, D. Fidalgo, Juri Poutanen, Julian Sitarek, J. Hose, K. Nishijima, Daniela Hadasch, Francesco Dazzi, A. Fernández-Barral, A. Niedzwiecki, P. G. Prada Moroni, David Paneque, M. Hayashida, D. Guberman, D. Zarić, Marina Manganaro, Marc Ribó, D. Galindo, P. Bangale, Hidetoshi Kubo, P. Cumani, Konstancja Satalecka, Michele Doro, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Babić, A., Banerjee, B., Bangale, P., de Almeida, U. Barre, Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Berti, Alessio, Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carosi, R., Carosi, A., Chatterjee, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Wilhelmi, E. de Oña, Pierro, F. Di, Doert, M., Domínguez, A., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Engelkemeier, M., Ramazani, V. Fallah, Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Gozzini, S. R., Griffiths, S., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, Francesco, López, M., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nieva, Nilsson, K., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Poutanen, J., Moroni, P. G. Prada, Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Sillanpää, A., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Torres, D. F., Torres Albà, N., Treves, A., Vanzo, G., Acosta, M. Vazquez, Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zarić, D., Collaboration), (MAGIC, Cognard, I., Guillemot, L., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Instituto de Fisica Corpuscular (IFIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universitat de València (UV), Nuclear Physics Division, Bhabha Atomic Research Centre (BARC), Government of India, Department of Atomic Energy-Government of India, Department of Atomic Energy, Politecnico di Milano [Milan] (POLIMI), INAF - Osservatorio Astronomico di Brera (OAB), Istituto Nazionale di Astrofisica (INAF), Technische Universität Dortmund [Dortmund] (TU), Institut de Física d’Altes Energies [Barcelone] (IFAE), Universitat Autònoma de Barcelona (UAB), IEEC-CSIC, Institut de Física d'Altes Energies, Institut d'Estudis Espacials de Catalunya (IEEC-CSIC), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Università degli Studi di Udine - University of Udine [Italie], Universita degli Studi di Padova, Max-Planck-Institut für Physik (Werner-Heisenberg-Institut) (MPI-P), Institute for Physical Research (IPR), National Academy of Sciences of the Republic of Armenia [Yerevan] (NAS RA), Universitat de Barcelona (UB), INAF - Osservatorio Astronomico di Trieste (OAT), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dept. of Physics, Institut de Ciencies del Cosmos (ICCUB), Department of Environment and Energy [Sendai], Tohoku University [Sendai], Optoelectronic Research Centre, University of Southampton, Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Padova = University of Padua (Unipd), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
non-thermal ,pulsars: general ,binaries: close ,pulsars: individual: B1957+20 ,gamma-rays: general [radiation mechanisms] ,Radiation mechanisms: non-thermal ,VHE [gamma ray] ,Astrophysics ,spin ,01 natural sciences ,7. Clean energy ,star ,emission [pulsar] ,Millisecond pulsar ,Pulsars: general ,radiation mechanisms: non-thermal ,gamma rays: general ,Astrophysics::Solar and Stellar Astrophysics ,010303 astronomy & astrophysics ,ComputingMilieux_MISCELLANEOUS ,High Energy Astrophysical Phenomena (astro-ph.HE) ,acceleration [electron] ,Physics ,radio wave ,Superluminal motion ,efficiency [acceleration] ,non-thermal, binaries: close, pulsars: general, pulsars: individual: B1957+20, gamma-rays: general [radiation mechanisms] ,inverse [Compton scattering] ,frequency ,compact [binary] ,symbols ,Electrónica ,Física nuclear ,Electricidad ,Astrophysics - High Energy Astrophysical Phenomena ,upper limit ,Active galactic nucleus ,Pulsars: individual: B1957+20 ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Lorentz covariance ,GLAST ,Binary pulsar ,symbols.namesake ,Pulsar ,Binaries: close ,0103 physical sciences ,interaction [pulsar] ,plasma ,radiation mechanisms: non-thermal, binaries: close, pulsars: general, pulsars: individual: B1957+20, gamma-rays: general ,Astrophysics::Galaxy Astrophysics ,Gamma-rays: general ,Planck energy ,ta115 ,010308 nuclear & particles physics ,Crab Pulsar ,[SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR] ,binary [pulsar] ,Astronomy and Astrophysics ,injection [electron] ,MAGIC ,13. Climate action ,Space and Planetary Science ,ddc:520 ,mass - Abstract
B1957+20 is a millisecond pulsar located in a black-widow-type compact binary system with a low-mass stellar companion. The interaction of the pulsar wind with the companion star wind and/or the interstellar plasma is expected to create plausible conditions for acceleration of electrons to TeV energies and subsequent production of very high-energy γ-rays in the inverse Compton process. We performed extensive observations with the Major Atmospheric Gamma Imaging Cherenkov Telescopes (MAGIC) telescopes of B1957+20. We interpret results in the framework of a few different models, namely emission from the vicinity of the millisecond pulsar, the interaction of the pulsar and stellar companion wind region or bow shock nebula. No significant steady very high-energy γ-ray emission was found. We derived a 95 per cent confidence level upper limit of 3.0 × 10−12 cm−2 s−1 on the average γ-ray emission from the binary system above 200 GeV. The upper limits obtained with the MAGIC constrain, for the first time, different models of the high-energy emission in B1957+20. In particular, in the inner mixed wind nebula model with mono-energetic injection of electrons, the acceleration efficiency of electrons is constrained to be below ∼2–10 per cent of the pulsar spin-down power. For the pulsar emission, the obtained upper limits for each emission peak are well above the exponential cut-off fits to the Fermi-LAT data, extrapolated to energies above 50 GeV. The MAGIC upper limits can rule out a simple power-law tail extension through the sub-TeV energy range for the main peak seen at radio frequencies., Monthly Notices of the Royal Astronomical Society, 470 (4), ISSN:0035-8711, ISSN:1365-2966, ISSN:1365-8711
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- 2017
194. MAGIC observations of the microquasar V404 Cygni during the 2015 outburst
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M. I. Martínez, Sabrina Einecke, Daniela Dorner, Dariusz Gora, A. Sillanpää, R. J. García López, Kazuma Ishio, Gaia Vanzo, A. Loh, Francesco Dazzi, A. Fernández-Barral, A. Niedzwiecki, U. Barres de Almeida, F. Di Pierro, A. De Angelis, Massimo Persic, Damir Lelas, M. Gaug, A. Treves, Vitaly Neustroev, L. Maraschi, Elina Lindfors, B. De Lotto, D. Hadasch, Stefano Ansoldi, David Paneque, Riccardo Paoletti, Dorota Sobczyńska, Daniel Mazin, J. Becerra González, Marcel Strzys, D. Guberman, J. Herrera, M. Vazquez Acosta, Pratik Majumdar, J. Palacio, Marina Manganaro, M. V. Fonseca, Rodolfo Carosi, Jerome Rodriguez, D. Galindo, J. M. Paredes, Christian Fruck, Antonio Stamerra, Giacomo Bonnoli, Koji Noda, B. Biasuzzi, Elisa Bernardini, Stefano Covino, E. Prandini, E. Colombo, Victoria Moreno, P. Cumani, Konstancja Satalecka, Michele Doro, G. Maneva, Tomoki Saito, D. Tescaro, U. Menzel, D. Kuveždić, Alessio Berti, Mosè Mariotti, Adrian Biland, D. Ninci, P. G. Prada Moroni, P. Da Vela, J. Rico, M. Hayashida, S. Schroeder, Ivica Puljak, D. Elsaesser, Diego F. Torres, Juan Abel Barrio, Pierre Colin, Nikola Godinovic, M. Peresano, D. Zarić, M. Garczarczyk, Dario Hrupec, M. Doert, P. Temnikov, Marc Ribó, P. Bangale, M. A. Lopez, Hidetoshi Kubo, Saverio Lombardi, Tomislav Terzić, S. Bonnefoy, Abelardo Moralejo, L. Nogués, M. Engelkemeier, E. Moretti, L. Perri, R. Mirzoyan, Arka Chatterjee, E. de Oña Wilhelmi, S. Griffiths, Ievgen Vovk, D. Fidalgo, J. R. Garcia, Alexander Hahn, Masahiro Teshima, Aaron Dominguez, T. Schweizer, Kyoshi Nishijima, Yusuke Konno, Gareth Hughes, Francesco Longo, D. Eisenacher Glawion, D. Dominis Prester, M. Minev, X. Paredes-Fortuny, Camilla Maggio, M. Nievas Rosillo, I. Reichardt, J. E. Ward, Julian Sitarek, V. Fallah Ramazani, J. Hose, Martin Makariev, Oscar Blanch, Wlodek Bednarek, Alessandro Carosi, S. Paiano, Karl Mannheim, N. Torres-Albà, G. Pedaletti, Wolfgang Rhode, T. Surić, B. Banerjee, C. Arcaro, L. A. Antonelli, Tarek M. Hassan, Fabrizio Tavecchio, Ll. Font, Ana Babić, Max Ludwig Ahnen, J. Kushida, Jose Luis Contreras, P. Giammaria, Juan Cortina, I. Snidaric, L. Takalo, Kari Nilsson, M. Will, Institut de Física d’Altes Energies [Barcelone] (IFAE), Universitat Autònoma de Barcelona (UAB), Max-Planck-Institut für Physik (Werner-Heisenberg-Institut) (MPI-P), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, The German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, CSD2009-00064), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia \Severo Ochoa' SEV-2012-0234 and SEV-2015-0548, and Unidad de Excelencia \Mara de Maeztu'MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project 09/176 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, and by the Polish MNiSzW grant 2016/22/M/ST9/00382., Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Babić, A., Banerjee, B., Bangale, P., Barres de Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, Alessio, Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Carosi, R., Carosi, A., Chatterjee, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., de Oña Wilhelmi, E., Di Pierro, F., Doert, M., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher Glawion, D., Elsaesser, D., Engelkemeier, M., Fallah Ramazani, V., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Griffiths, S., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, Francesco, López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Minev, M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Sillanpää, A., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Torres, D. F., Torres Albà, N., Treves, A., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Collaboration), (The MAGIC, Loh, A., and Rodriguez, J.
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Flux ,Astrophysics ,7. Clean energy ,01 natural sciences ,law.invention ,general [, gamma-rays] ,law ,Astrophysics::Solar and Stellar Astrophysics ,MAGIC (telescope) ,010303 astronomy & astrophysics ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,radio wave ,Gamma-rays: general ,Stars: individual: V404 Cygni (V404 Cyg) ,X-rays: binaries ,Electrónica ,Física nuclear ,Electricidad ,Astrophysics - High Energy Astrophysical Phenomena ,burst ,Flare ,Radio wave ,exceptional ,Opacity ,gamma-rays: general ,stars: individual: V404 Cygni (V404 Cyg) ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Compact star ,GLAST ,VHE ,X-ray ,0103 physical sciences ,upper limit [flux] ,quasar ,ta115 ,010308 nuclear & particles physics ,Astronomy ,opacity ,Astronomy and Astrophysics ,Quasar ,acceleration ,MAGIC ,Crab Nebula ,13. Climate action ,Space and Planetary Science ,gamma ray ,[SDU]Sciences of the Universe [physics] ,ddc:520 ,binaries [X-rays] ,individual: V404 Cygni (V404 Cyg) [stars] - Abstract
The microquasar V404 Cygni underwent a series of outbursts in 2015, June 15-31, during which its flux in hard X-rays (20-40 keV) reached about 40 times the Crab Nebula flux. Because of the exceptional interest of the flaring activity from this source, observations at several wavelengths were conducted. The MAGIC telescopes, triggered by the INTEGRAL alerts, followed-up the flaring source for several nights during the period June 18-27, for more than 10 hours. One hour of observation was conducted simultaneously to a giant 22 GHz radio flare and a hint of signal at GeV energies seen by Fermi-LAT. The MAGIC observations did not show significant emission in any of the analysed time intervals. The derived flux upper limit, in the energy range 200--1250 GeV, is 4.8$\times 10^{-12}$ ph cm$^{-2}$ s$^{-1}$. We estimate the gamma-ray opacity during the flaring period, which along with our non-detection, points to an inefficient acceleration in the V404\,Cyg jets if VHE emitter is located further than $1\times 10^{10}$ cm from the compact object., Comment: 7 pages, accepted by MNRAS
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- 2017
195. A cut-off in the TeV gamma-ray spectrum of the SNR Cassiopeia A
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G. Pedaletti, E. Prandini, Stefano Ansoldi, Riccardo Paoletti, Wolfgang Rhode, A. De Angelis, A. Treves, Vitaly Neustroev, T. Surić, M. I. Martínez, Juan Abel Barrio, M. Engelkemeier, B. De Lotto, S. Bonnefoy, Sabrina Einecke, L. Maraschi, Kazuma Ishio, Elina Lindfors, G. Maneva, J. Kushida, Razmik Mirzoyan, U. Barres de Almeida, Damir Lelas, Rodolfo Carosi, Daniel Mazin, A. Berti, Wlodek Bednarek, Alessandro Carosi, Jose Luis Contreras, Adrian Biland, Chiara Righi, Dorota Sobczyńska, M. Colak, N. Torres-Albà, J. Palacio, M. Hayashida, J. Rico, Camilla Maggio, J. M. Paredes, Antonio Stamerra, B. Banerjee, Daniela Dorner, C. Arcaro, Dariusz Gora, Juan Cortina, Gaia Vanzo, D. Zarić, Arka Chatterjee, S. Schroeder, Marc Ribó, Stefano Covino, Ivica Puljak, Pierre Colin, M. Gaug, Pratik Majumdar, L. Nogués, D. Fidalgo, P. Bangale, M. V. Fonseca, Abelardo Moralejo, E. Moretti, Hidetoshi Kubo, Tomohiro Inada, L. A. Antonelli, J. Herrera, S. N. Shore, E. de Oña Wilhelmi, Martin Will, Petar Temnikov, Koji Noda, Tomoki Saito, D. Tescaro, Marcel Strzys, Elisa Bernardini, Masahiro Teshima, Yusuke Konno, P. G. Prada Moroni, Kyoshi Nishijima, Nikola Godinovic, D. Ninci, D. Kuveždić, Tomislav Terzić, Ievgen Vovk, M. Minev, Tarek M. Hassan, T. Schweizer, I. Reichardt, Fabrizio Tavecchio, A. Niedzwiecki, Ll. Font, I. Snidaric, U. Menzel, M. Peresano, David Paneque, Max Ludwig Ahnen, P. Giammaria, D. Guberman, Marina Manganaro, Ana Babić, D. Galindo, M. Garczarczyk, P. Cumani, Konstancja Satalecka, Michele Doro, Francesco Dazzi, Dario Hrupec, A. Fernández-Barral, M. A. Lopez, R. J. García López, Kari Nilsson, Massimo Persic, F. Di Pierro, D. Dominis Prester, V. Fallah Ramazani, P. Da Vela, Alexander Hahn, Julian Sitarek, J. Hose, M. Vazquez Acosta, B. Biasuzzi, Victoria Moreno, E. Colombo, L. O. Takalo, Aaron Dominguez, D. Hadasch, Francesco Longo, J. E. Ward, Mosè Mariotti, Saverio Lombardi, Martin Makariev, Oscar Blanch, M. Doert, J. R. Garcia, J. Becerra González, Christian Fruck, L. Perri, Giacomo Bonnoli, Wrijupan Bhattacharyya, D. Eisenacher Glawion, D. Elsaesser, M. Nievas Rosillo, S. Paiano, Karl Mannheim, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Arcaro, C., Babić, A., Banerjee, B., Bangale, P., Barres de Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, A., Bhattacharyya, W., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Carosi, R., Carosi, A., Chatterjee, A., Colak, M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., de Oña Wilhelmi, E., Di Pierro, F., Doert, M., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher Glawion, D., Elsaesser, D., Engelkemeier, M., Fallah Ramazani, V., Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Inada, T., Ishio, K., Konno, Y., Kubo, H., Kushida, J., Kuveždić, D., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Minev, M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Shore, S. N., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Torres-Albà, N., Treves, A., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., and Zarić, D.
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lepton ,Astrophysics ,power spectrum ,01 natural sciences ,Spectral line ,Astrophysics::Solar and Stellar Astrophysics ,MAGIC (telescope) ,010303 astronomy & astrophysics ,acceleration of particle ,cosmic ray ,energy spectrum [gamma ray] ,acceleration of particles ,ISM: supernova remnants ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,Spectral index ,education.field_of_study ,Gamma ray ,cosmic rays ,gamma rays: general ,high [energy] ,Spectral energy distribution ,Electrónica ,Física nuclear ,Electricidad ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics::High Energy Astrophysical Phenomena ,low [magnetic field] ,Population ,energy spectrum ,FOS: Physical sciences ,Cosmic ray ,Astrophysics::Cosmology and Extragalactic Astrophysics ,GLAST ,leptonic [model] ,emission [gamma ray] ,supernova ,0103 physical sciences ,education ,Astrophysics::Galaxy Astrophysics ,Computer Science::Information Theory ,ta115 ,010308 nuclear & particles physics ,Astronomy ,cosmic ray physics ,stars: supernovae: individual: Cassiopeia A ,supernova remnants ,Astronomy and Astrophysics ,acceleration ,MAGIC ,moment ,flux ,Cassiopeia A ,Space and Planetary Science ,ddc:520 ,galaxy [cosmic radiation] ,spectral ,High Energy Physics::Experiment ,supernova remnant [ISM] ,general [gamma rays] - Abstract
It is widely believed that the bulk of the Galactic cosmic rays are accelerated in supernova remnants (SNRs). However, no observational evidence of the presence of particles of PeV energies in SNRs has yet been found. The young historical SNR Cassiopeia A (Cas A) appears as one of the best candidates to study acceleration processes. Between December 2014 and October 2016 we observed Cas A with the MAGIC telescopes, accumulating 158 hours of good-quality data. We derived the spectrum of the source from 100 GeV to 10 TeV. We also analysed $\sim$8 years of $Fermi$-LAT to obtain the spectral shape between 60 MeV and 500 GeV. The spectra measured by the LAT and MAGIC telescopes are compatible within the errors and show a clear turn off (4.6 $\sigma$) at the highest energies, which can be described with an exponential cut-off at $E_c = 3.5\left(^{+1.6}_{-1.0}\right)_{\textit{stat}} \left(^{+0.8}_{-0.9}\right)_{\textit{sys}}$ TeV. The gamma-ray emission from 60 MeV to 10 TeV can be attributed to a population of high-energy protons with spectral index $\sim$2.2 and energy cut-off at $\sim$10 TeV. This result indicates that Cas A is not contributing to the high energy ($\sim$PeV) cosmic-ray sea in a significant manner at the present moment. A one-zone leptonic model fails to reproduce by itself the multi-wavelength spectral energy distribution. Besides, if a non-negligible fraction of the flux seen by MAGIC is produced by leptons, the radiation should be emitted in a region with a low magnetic field (B$\lessapprox$100$\mu$G) like in the reverse shock.), Comment: 8 pages, 3 figures, submitted to MNRAS. Corresponding authors: Daniel Guberman (dguberman@ifae.es), Emma de O\~na Wilhelmi (wilhelmi@ice.csic.es) and Daniel Galindo (dgalindo@am.ub.es)
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- 2017
196. Science with e-ASTROGAM
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De Angelis, A., Tatischeff, V., Grenier, I. A., Mcenery, J., Mallamaci, Manuela, Tavani, M., Oberlack, U., Hanlon, L., Walter, R., Argan, A., Von Ballmoos, P., Bulgarelli, A., Bykov, A., Hernanz, M., Kanbach, G., Kuvvetli, I., Pearce, MARK JOHN, Zdziarski, A., Conrad, J., Ghisellini, Giulia, Harding, ANTHONY FILMER, Isern, J., Leising, M., Longo, F., Madejski, G., Martinez, M., Mazziotta, M. N., Paredes, J. M., Pohl, M., Rando, R., Razzano, M., Aboudan, A., Ackermann, M., Addazi, A., Ajello, M., Albertus, C., Álvarez, J. M., Ambrosi, G., Antón, S., Antonelli, L. A., Babic, A., Baibussinov, B., Balbo, M., Baldini, L., Balman, S., Bambi, Cosimo, Barres de Almeida, U., Barrio, J. A., Bartels, R., Bastieri, D., Bednarek, W., Bernard, D., Bernardini, E., Bernasconi, T., Bertucci, B., Biland, A., Bissaldi, E., Boettcher, M., Bonvicini, V., Bosch-Ramon, V., Bottacini, E., Bozhilov, V., Bretz, T., Branchesi, M., Brdar, V., Bringmann, T., Brogna, A., Budtz Jørgensen, C., Busetto, G., Buson, S., Busso, M., Caccianiga, A., Camera, Stefania, Campana, R., Caraveo, P., Cardillo, M., Carlson, P., Celestin, S., Cermeño, M., Chen, A., Cheung, C. C., Churazov, E., Ciprini, S., Coc, A., Colafrancesco, S., Coleiro, A., Collmar, W., Coppi, P., Curado da Silva, R., Cutini, S., D'Ammando, F., De Lotto, B., DE MARTINO, Domitilla, De Rosa, A., Del Santo, M., Delgado, L., Diehl, R., Dietrich, S., Dolgov, A. D., Domínguez, A., Dominis Prester, D., Donnarumma, I., Dorner, D., Doro, M., Dutra, M., Elsaesser, D., Fabrizio, M., Fernández-Barral, A., Fioretti, V., Foffano, L., Formato, V., Fornengo, N., Foschini, L., Franceschini, A., Franckowiak, A., Funk, S., Fuschino, F., Gaggero, D., Galanti, Giulia, Gargano, F., Gasparrini, Dario, Gehrz, R., Giammaria, P., Giglietto, N., Giommi, P., Giordano, F., Giroletti, M., Ghirlanda, Giuseppe, Godinovic, N., Gouiffés, C., Grove, J. E., Hamadache, C., Hartmann, D. H., Hayashida, M., Hryczuk, A., Jean, P., Johnson, T., José, J., Kaufmann, STEFAN H. E., Khelifi, B., Kiener, J., Knödlseder, J., Kole, M., Kopp, J., Kozhuharov, V., Labanti, C., Lalkovski, S., Laurent, P., Limousin, O., Linares, M., Lindfors, E., Lindner, M., Liu, Jia, Lombardi, S., Loparco, F., López-Coto, R., LOPEZ MOYA, Marcos, Lott, B., Lubrano, P., Malyshev, D., Mankuzhiyil, N., Mannheim, K., Marchã, M. J., Marciano', Antonino, Marcote, B., Mariotti, M., Marisaldi, M., Mcbreen, S., Mereghetti, Sandro, Merle, A., Mignani, R., Minervini, G., Moiseev, A., Morselli, A., Moura, F., Nakazawa, K., Nava, L., Nieto, D., Orienti, M., Orio, Marina, Orlando, E., Orleanski, P., Paiano, S., Paoletti, R., Papitto, A., Pasquato, M., Patricelli, B., Pérez-García, M. Á., Persic, M., Piano, G., Pichel, A., Pimenta, M., Pittori, C., Porter, T., Poutanen, J., Prandini, E., Prantzos, N., Produit, N., Profumo, S., Queiroz, F. S., Rainó, S., Raklev, A., Breton, REGIS MICHEL FERNAND, Reichardt, I., Rephaeli, Y., Rico, J., Rodejohann, W., Rodriguez Fernandez, G., Roncadelli, M., Roso, L., Rovero, A., Ruffini, R., Sala, G., Sánchez-Conde, M. A., Santangelo, A., Saz Parkinson, P., Sbarrato, T., Shearer, A., Shellard, R., Short, K., Siegert, T., Siqueira, C., Spinelli, P., Stamerra, A., Starrfield, S., Strong, A., Strümke, I., Tavecchio, F., Taverna, R., Terzić, T., Thompson, D. J., Tibolla, O., Torres, D. F., Turolla, R., Ulyanov, A., Ursi, A., Vacchi, A., Van den Abeele, J., Vankova-Kirilovai, G., Venter, CHRISTINE MARY, Verrecchia, F., Vincent, P., Wang, Xumei, Weniger, C., Wu, X., Zaharijaš, G., Zampieri, L., Zane, S., Zimmer, S., Zoglauer, A., and Franceschini, Alberto
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Physics ,Calorimeter (particle physics) ,Astrophysics::High Energy Astrophysical Phenomena ,media_common.quotation_subject ,Detector ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astronomy ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Photon energy ,7. Clean energy ,01 natural sciences ,Universe ,Galaxy ,Supernova ,KM3NeT ,13. Climate action ,Space and Planetary Science ,Observatory ,0103 physical sciences ,010306 general physics ,010303 astronomy & astrophysics ,media_common - Abstract
e-ASTROGAM (enhanced ASTROGAM) is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV - the lower energy limit can be pushed to energies as low as 150 keV for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and LISA.
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- 2018
197. Urothelial organoids originate from Cd49fHigh stem cells and display Notch-dependent differentiation capacity
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Antonio Barbáchano, Diego Megías, Catarina P. Santos, Eleonora Lapi, Laura Alvaro-Espinosa, Alberto Muñoz, Francisco X. Real, and A. Fernández-Barral
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Transcriptome ,Cellular differentiation ,Organoid ,Uroplakins ,Wnt signaling pathway ,Notch signaling pathway ,Biology ,Stem cell ,Urothelium ,Cell biology - Abstract
SummaryThe urothelium is a specialized stratified epithelium with unique structural and functional features. Understanding the mechanisms involved in urothelial stem cell biology and differentiation has been limited by the lack of methods for unlimited propagation. Here, we establish normal mouse urothelial organoid (NMU-o) cultures that can be maintained uninterruptedly for >1 year. Organoid growth is dependent on EGF and Wnt activators. High CD49f/ITGA6 expression features a subpopulation of organoid-forming urothelial stem cells expressing basal markers. On induction of differentiation, multilayered organoids show reduced layer number, acquire barrier function, and activate the urothelial program, including expression of uroplakins and tight junction components. Combined pharmacological modulation of PPARγ and EGFR was most potent driving cell differentiation. Transcriptome analysis of organoids widely validates the system, highlights the transcriptional networks involved, and reveals NOTCH signaling as a novel pathway required for normal urothelial organoid differentiation.
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- 2018
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198. Human normal and tumor colorectal organoids: Gene expression studies
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Barbáchano, Antonio, Fernández-Barral, A., Costales-Carrera, Alba, and Muñoz Terol, Alberto
- Abstract
Trabajo presentado al XXXIX Congreso de la Sociedad Española de Ciencias Fisiológicas (SECF), celebrado en Cádiz del 18 al 21 de septiembre de 2018.
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- 2018
199. Detection of persistent VHE gamma-ray emission from PKS 1510-089 by the MAGIC telescopes during low states between 2012 and 2017
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Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Gallozzi, S., López, R. J. García, Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuveždić, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Oramas, A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Raiteri, C. M., Sandrinelli, A., Hovatta, T., and Kiehlmann, S.
- Abstract
Astronomy and astrophysics 619, A159 (2018). doi:10.1051/0004-6361/201833618, Context. PKS 1510–089 is a flat spectrum radio quasar strongly variable in the optical and GeV range. To date, very high-energy (VHE, > 100 GeV) emission has been observed from this source either during long high states of optical and GeV activity or during short flares.Aims. We search for low-state VHE gamma-ray emission from PKS 1510–089. We characterize and model the source in a broadband context, which would provide a baseline over which high states and flares could be better understood.Methods. PKS 1510–089 has been monitored by the MAGIC telescopes since 2012. We use daily binned Fermi-LAT flux measurements of PKS 1510–089 to characterize the GeV emission and select the observation periods of MAGIC during low state of activity. For the selected times we compute the average radio, IR, optical, UV, X-ray, and gamma-ray emission to construct a low-state spectral energy distribution of the source. The broadband emission is modeled within an external Compton scenario with a stationary emission region through which plasma and magnetic fields are flowing. We also perform the emission-model-independent calculations of the maximum absorption in the broad line region (BLR) using two different models.Results. The MAGIC telescopes collected 75 hr of data during times when the Fermi-LAT flux measured above 1 GeV was below 3 × 10$^{−8}$ cm$^{−2}$ s$^{−1}$, which is the threshold adopted for the definition of a low gamma-ray activity state. The data show a strongly significant (9.5σ) VHE gamma-ray emission at the level of (4.27 ± 0.61$_{stat}$) × 10$^{−12}$ cm$^{−2}$ s$^{−1}$ above 150 GeV, a factor of 80 lower than the highest flare observed so far from this object. Despite the lower flux, the spectral shape is consistent with earlier detections in the VHE band. The broadband emission is compatible with the external Compton scenario assuming a large emission region located beyond the BLR. For the first time the gamma-ray data allow us to place a limit on the location of the emission region during a low gamma-ray state of a FSRQ. For the used model of the BLR, the 95% confidence level on the location of the emission region allows us to place it at a distance > 74% of the outer radius of the BLR., Published by EDP Sciences, Les Ulis
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- 2018
- Full Text
- View/download PDF
200. The broad-band properties of the intermediate synchrotron peaked BL Lac S2 0109+22 from radio to VHE gamma rays
- Author
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Ansoldi, S., Antonelli, L. A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berse, R Ch, Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D’Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Gallozzi, S., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Konno, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Mielke, K., Minev, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Pfrang, K., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., Ciprini, S., Desiante, R., Barcewicz, S., Hovatta, T., Jormanainen, J., Takalo, L., Reinthal, R., Mankuzhiyil, N., Wierda, F., Lähteenmäki, A., Tammi, J., Tornikoski, M., Vera, R. J. C., Kiehlmann, S., Max-Moerbeck, W., and Readhead, A. C. S.
- Subjects
Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Cosmology and Extragalactic Astrophysics - Abstract
The MAGIC telescopes observed S2 0109+22 in 2015 July during its flaring activity in high energy gamma rays observed by Fermi-LAT. We analyse the MAGIC data to characterise the very high energy (VHE) gamma-ray emission of S2 0109+22, which belongs to the subclass of intermediate synchrotron peak (ISP) BL Lac objects. We study the multi-frequency emission in order to investigate the source classification. Finally, we compare the source long-term behaviour to other VHE gamma-ray emitting (TeV) blazars. We performed a temporal and spectral analysis of the data centred around the MAGIC interval of observation (MJD 57225-57231). Long-term radio and optical data have also been investigated using the discrete correlation function. The redshift of the source is estimated through optical host-galaxy imaging and also using the amount of VHE gamma-ray absorption. The quasi-simultaneous multi-frequency spectral energy distribution (SED) is modelled with the conventional one-zone synchrotron self-Compton (SSC) model. MAGIC observations resulted in the detection of the source at a significance level of $5.3\,\sigma$. The VHE gamma-ray emission of S2 0109+22 is variable on a daily time scale. VHE gamma-ray luminosity of the source is lower than the average of TeV BL Lacs. The optical polarization, and long-term optical/radio behaviour of the source are different from the general population of TeV blazars. All these findings agree with the classification of the source as an ISP BL Lac object. We estimate the source redshift as $z = 0.36 \pm 0.07$. The SSC parameters describing the SED are rather typical for blazars.
- Published
- 2018
- Full Text
- View/download PDF
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