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593 results on '"Ferdeghini M"'

158. Oxidative and genotoxic damage after radio‐iodine therapy of Graves' hyperthyroidism

Author

Ballardin, M., primary, Barsacchi, R., additional, Bodei, L., additional, Caraccio, N., additional, Cristofani, R., additional, Di martino, F., additional, Ferdeghini, M., additional, Kusmic, C., additional, Madeddu, G., additional, Monzani, F., additional, Rossi, A. M., additional, Sbrana, I., additional, Spanu, A., additional, Traino, C., additional, and Barale, R., additional

Published
2004
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161. Prospective multicenter study on the clinical utility of CA 72.4 in post-menopausal patients with pelvic mass

Author

Maggino, T, Gadducci, A, Daddario, V, Pecorelli, S, Lissoni, A, Stella, M, Romagnolo, C, Ferdeghini, M, Zucca, S, Trio, D, Trovo, S, Trovo, S., LISSONI, ANDREA ALBERTO, Maggino, T, Gadducci, A, Daddario, V, Pecorelli, S, Lissoni, A, Stella, M, Romagnolo, C, Ferdeghini, M, Zucca, S, Trio, D, Trovo, S, Trovo, S., and LISSONI, ANDREA ALBERTO

Abstract

The study objective was to evaluate the sensitivity and specificity as well as the positive predictive value and negative predictive value of CA 72.4 and CA 125 determination, separately and in combination, for diagnosing ovarian tumors in post-menopausal women with pelvic mass. The 299 patients recruited in this study underwent gynecological examination, plasma determination of CA 72.4 and CA 125, and laparotomy with histological definition of pelvic mass. CA 72.4 assay values were under 3.9 U/ml in 194 cases (70.8%); values ranged from 3.9 to 4.5 U/ml in 7 cases (2.5%) and were greater than 4.5 U/ml in 73 cases (26.6%). CA 72.4 assay was positive (>4.5 U/ml) in 56 cases (57.1%) of malignant ovarian pathology, in 4 cases (25%) of malignant extra-ovarian pathology as well as in 9 cases (7.1%) of benign ovarian pathology and in 4 cases (11.8%) of benign extra-ovarian pathology. With a cut-off at 3.9 U/ml, CA 72.4 showed a specificity of 91.3% and a sensitivity of 62.2%, whereas with a cut-off at 4.5 U/ml specificity was 92.9% and sensitivity 57.1%. Results of CA 125 assay for diagnosing a pelvic neoplasia (ovarian or extra-ovarian), showed a specificity of 85.3% and sensitivity of 68.8%. The agreement of the two markers (CA 125 and CA 72.4) as negative or positive shows a specificity of 77% and a sensitivity of 84.7% for ovarian cancer and a specificity of 73.5% and sensitivity of 75% for the diagnosis of pelvic neoplasias.

Published
1995

195. Dual PET/CT with 18F-DOPA and 18F-FDG in metastatic medullary thyroid carcinoma and rapidly increasing calcitonin levels: Comparison with conventional imaging.

Author

Marzola, M.C., Pelizzo, M.R., Ferdeghini, M., Toniato, A., Massaro, A., Ambrosini, V., Fanti, S., Gross, M.D., Al-Nahhas, A., and Rubello, D.

Subjects
THYROID cancer patients, CALCITONIN, CANCER relapse, FOLLOW-up studies (Medicine), THYROIDECTOMY, CANCER tomography
Abstract

Abstract: Background: To evaluate the role of a multi-imaging PET with 18F-DOPA and 18F-FDG in comparison with conventional imaging (CI) in recurrent medullary thyroid carcinoma (MTC). Methods: 18 MTC patients who had thyroidectomy were included; they presented with elevated and rapidly increasing calcitonin levels during follow up. CI had revealed metastatic deposits in 9 patients. Patients were referred to us for a PET/CT with 18F-DOPA and 18F-FDG. Histologic/cytologic confirmation of recurrent MTC was obtained in at least one PET-positive lesion in all patients. Results: Foci of abnormal uptake were observed in 15 patients at 18F-DOPA and in 11 at 18F-FDG; 8 patients showed the same number of positive lesions with both tracers, 2 showed more lesions on 18F-FDG, 1 was positive at 18F-FDG alone and 5 at 18F-DOPA alone. In 3 patients with a DOPA-positive loco-regional relapse a re-operation with curative intent was offered. SUVmax values were higher for 18F-FDG compared to 18F-DOPA (mean 12.7±4.1 vs. 5.5±2.1, p <0.05). Calcitonin was higher in PET-positive patients compared to PET negative ones, while no significant differences were observed between 18F-DOPA and 18F-FDG positive patients. Conclusions: In MTC patients with rapidly increasing calcitonin levels during follow up, 18F-DOPA has a good sensitivity and a complementary role with 18F-FDG PET/CT in detecting metastatic deposits. In our experience, the sensitivity of a multi-imaging 18F-DOPA &18F-FDG PET/CT approach is greater than that obtained with CI. The higher SUVmax values found with 18F-FDG in some patients may reflect more aggressive tumors. [Copyright &y& Elsevier]

Published
2010
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199. The role of 18F-FDG PET/CT in detecting metastatic deposits of recurrent medullary thyroid carcinoma: A prospective study.

Author

Rubello, D., Rampin, L., Nanni, C., Banti, E., Ferdeghini, M., Fanti, S., Al-Nahhas, A., and Gross, M.D.

Subjects
BLOOD plasma, CANCER patients, MEDICAL imaging systems, CALCITONIN
Abstract

Abstract: Aim: To assess the diagnostic role of 18F-FDG PET/CT performed with a hybrid tomograph in the detection of tumoral deposits of recurrent medullary thyroid carcinoma (MTC). Methods: Nineteen MTC patients with elevated serum calcitonin levels (58–1350pg/ml) after first treatment were enrolled (11 F, 8 M, mean age 53.4years, 14sporadic MTC, 5 MEN-related MTC). All patients had previously undergone total thyroidectomy and lymphoadenectomy. When referred to us, they were studied with ultrasound (US), 18F-FDG PET/CT, 111In-pentetreotide scan, and contrast-enhanced whole-body CT (c.e. CT). In 4 patients with equivocal abdominal findings at 18F-FDG PET/CT and/or at c.e. CT, laparoscopy was also performed. Results: 18F-FGD PET/CT depicted metastases in 15 patients, 111In-pentetreotide in 8, c.e. CT in 11, US in 6. In 2 patients, liver micrometastases were detected at laparoscopy only. At a lesion-by-lesion analysis, 18F-FDG PET/CT visualized a total of 26 metastatic deposits, c.e. CT 18, 111In-pentetreotide 12, US 8. Final diagnosis was obtained by cytological or surgical findings. Four patients with evidence of limited metastatic spread to neck/upper mediastinum were re-operated, and in 2 of them serum calcitonin levels normalized. Conclusions: In our study, 18F-FDG PET/CT was the most sensitive imaging modality in detecting metastases in recurrent MTC patients with increased serum calcitonin levels. Moreover, 18F-FDG PET/CT was useful in some patients to plan a more accurate re-operation. From a diagnostic point of view, a multimodality imaging approach is recommended in recurrent MTC, especially based on the combination of c.e. CT and 18F-FDG PET/CT. [Copyright &y& Elsevier]

Published
2008
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