Search

Your search keyword '"Faye M."' showing total 3,838 results
Start Over Author "Faye M."
3,838 results on '"Faye M."'

151. Table S6 from PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Author

Sambandam, Vaishnavi, primary, Frederick, Mitchell J., primary, Shen, Li, primary, Tong, Pan, primary, Rao, Xiayu, primary, Peng, Shaohua, primary, Singh, Ratnakar, primary, Mazumdar, Tuhina, primary, Huang, Chenfei, primary, Li, Qiuli, primary, Pickering, Curtis R., primary, Myers, Jeffery N., primary, Wang, Jing, primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

152. Supplementary Table from Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Author

Ferrarotto, Renata, primary, Amit, Moran, primary, Nagarajan, Priyadharsini, primary, Rubin, M. Laura, primary, Yuan, Ying, primary, Bell, Diana, primary, El-Naggar, Adel K., primary, Johnson, Jason M., primary, Morrison, William H., primary, Rosenthal, David I., primary, Glisson, Bonnie S., primary, Johnson, Faye M., primary, Lu, Charles, primary, Mott, Frank E., primary, Esmaeli, Bita, primary, Diaz, Eduardo M., primary, Gidley, Paul W., primary, Goepfert, Ryan P., primary, Lewis, Carol M., primary, Weber, Randal S., primary, Wargo, Jennifer A., primary, Basu, Sreyashi, primary, Duan, Fei, primary, Yadav, Shalini S., primary, Sharma, Padmanee, primary, Allison, James P., primary, Myers, Jeffrey N., primary, and Gross, Neil D., primary

Published
2023
Full Text
View/download PDF

153. Supplementary Figure S7 from Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Author

Tanaka, Noriaki, primary, Patel, Ameeta A., primary, Wang, Jiping, primary, Frederick, Mitchell J., primary, Kalu, Nene N., primary, Zhao, Mei, primary, Fitzgerald, Alison L., primary, Xie, Tong-xin, primary, Silver, Natalie L., primary, Caulin, Carlos, primary, Zhou, Ge, primary, Skinner, Heath D., primary, Johnson, Faye M., primary, Myers, Jeffrey N., primary, and Osman, Abdullah A., primary

Published
2023
Full Text
View/download PDF

154. Figure S2 from PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Author

Sambandam, Vaishnavi, primary, Frederick, Mitchell J., primary, Shen, Li, primary, Tong, Pan, primary, Rao, Xiayu, primary, Peng, Shaohua, primary, Singh, Ratnakar, primary, Mazumdar, Tuhina, primary, Huang, Chenfei, primary, Li, Qiuli, primary, Pickering, Curtis R., primary, Myers, Jeffery N., primary, Wang, Jing, primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

155. Supplementary Table 1-3 from CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Author

Gadhikar, Mayur A., primary, Zhang, Jiexin, primary, Shen, Li, primary, Rao, Xiayu, primary, Wang, Jing, primary, Zhao, Mei, primary, Kalu, Nene N., primary, Johnson, Faye M., primary, Byers, Lauren A., primary, Heymach, John, primary, Hittelman, Walter N., primary, Udayakumar, Durga, primary, Pandita, Raj K., primary, Pandita, Tej K., primary, Pickering, Curtis R., primary, Redwood, Abena B., primary, Piwnica-Worms, Helen, primary, Schlacher, Katharina, primary, Frederick, Mitchell J., primary, and Myers, Jeffrey N., primary

Published
2023
Full Text
View/download PDF

156. Supplemental Figure 1 from Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Author

Ferrarotto, Renata, primary, Goonatilake, Ruchitha, primary, Young Yoo, Suk, primary, Tong, Pan, primary, Giri, Uma, primary, Peng, Shaohua, primary, Minna, John, primary, Girard, Luc, primary, Wang, Yuehong, primary, Wang, Liguang, primary, Li, Lerong, primary, Diao, Lixia, primary, Peng, David H., primary, Gibbons, Don L., primary, Glisson, Bonnie S., primary, Heymach, John V., primary, Wang, Jing, primary, Byers, Lauren A., primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

157. Supplemental Figure 4 from Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Author

Ferrarotto, Renata, primary, Goonatilake, Ruchitha, primary, Young Yoo, Suk, primary, Tong, Pan, primary, Giri, Uma, primary, Peng, Shaohua, primary, Minna, John, primary, Girard, Luc, primary, Wang, Yuehong, primary, Wang, Liguang, primary, Li, Lerong, primary, Diao, Lixia, primary, Peng, David H., primary, Gibbons, Don L., primary, Glisson, Bonnie S., primary, Heymach, John V., primary, Wang, Jing, primary, Byers, Lauren A., primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

158. Data from CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Author

Gadhikar, Mayur A., primary, Zhang, Jiexin, primary, Shen, Li, primary, Rao, Xiayu, primary, Wang, Jing, primary, Zhao, Mei, primary, Kalu, Nene N., primary, Johnson, Faye M., primary, Byers, Lauren A., primary, Heymach, John, primary, Hittelman, Walter N., primary, Udayakumar, Durga, primary, Pandita, Raj K., primary, Pandita, Tej K., primary, Pickering, Curtis R., primary, Redwood, Abena B., primary, Piwnica-Worms, Helen, primary, Schlacher, Katharina, primary, Frederick, Mitchell J., primary, and Myers, Jeffrey N., primary

Published
2023
Full Text
View/download PDF

159. Supplemental Figure 3 from Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Author

Ferrarotto, Renata, primary, Goonatilake, Ruchitha, primary, Young Yoo, Suk, primary, Tong, Pan, primary, Giri, Uma, primary, Peng, Shaohua, primary, Minna, John, primary, Girard, Luc, primary, Wang, Yuehong, primary, Wang, Liguang, primary, Li, Lerong, primary, Diao, Lixia, primary, Peng, David H., primary, Gibbons, Don L., primary, Glisson, Bonnie S., primary, Heymach, John V., primary, Wang, Jing, primary, Byers, Lauren A., primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

160. Supplementary Figure S3 - S4 from Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Author

Tanaka, Noriaki, primary, Patel, Ameeta A., primary, Wang, Jiping, primary, Frederick, Mitchell J., primary, Kalu, Nene N., primary, Zhao, Mei, primary, Fitzgerald, Alison L., primary, Xie, Tong-xin, primary, Silver, Natalie L., primary, Caulin, Carlos, primary, Zhou, Ge, primary, Skinner, Heath D., primary, Johnson, Faye M., primary, Myers, Jeffrey N., primary, and Osman, Abdullah A., primary

Published
2023
Full Text
View/download PDF

161. Supplementary Materials and Methods from Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Author

Tanaka, Noriaki, primary, Patel, Ameeta A., primary, Wang, Jiping, primary, Frederick, Mitchell J., primary, Kalu, Nene N., primary, Zhao, Mei, primary, Fitzgerald, Alison L., primary, Xie, Tong-xin, primary, Silver, Natalie L., primary, Caulin, Carlos, primary, Zhou, Ge, primary, Skinner, Heath D., primary, Johnson, Faye M., primary, Myers, Jeffrey N., primary, and Osman, Abdullah A., primary

Published
2023
Full Text
View/download PDF

162. Supplementary Figures from Essential Role of DNA Methyltransferase 1–mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors

Author

Min, Hye-Young, primary, Lee, Su-Chan, primary, Woo, Jong Kyu, primary, Jung, Hyun Jin, primary, Park, Kwan Hee, primary, Jeong, Hae Min, primary, Hyun, Seung Yeob, primary, Cho, Jaebeom, primary, Lee, Wooin, primary, Park, Ji Eun, primary, Kwon, So Jung, primary, Lee, Hyo-Jong, primary, Ni, Xiao, primary, Shin, Young Kee, primary, Johnson, Faye M., primary, Duvic, Madeleine, primary, and Lee, Ho-Young, primary

Published
2023
Full Text
View/download PDF

163. Supplementary Figure from Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Author

Ferrarotto, Renata, primary, Amit, Moran, primary, Nagarajan, Priyadharsini, primary, Rubin, M. Laura, primary, Yuan, Ying, primary, Bell, Diana, primary, El-Naggar, Adel K., primary, Johnson, Jason M., primary, Morrison, William H., primary, Rosenthal, David I., primary, Glisson, Bonnie S., primary, Johnson, Faye M., primary, Lu, Charles, primary, Mott, Frank E., primary, Esmaeli, Bita, primary, Diaz, Eduardo M., primary, Gidley, Paul W., primary, Goepfert, Ryan P., primary, Lewis, Carol M., primary, Weber, Randal S., primary, Wargo, Jennifer A., primary, Basu, Sreyashi, primary, Duan, Fei, primary, Yadav, Shalini S., primary, Sharma, Padmanee, primary, Allison, James P., primary, Myers, Jeffrey N., primary, and Gross, Neil D., primary

Published
2023
Full Text
View/download PDF

164. Figure S5 from CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Author

Gadhikar, Mayur A., primary, Zhang, Jiexin, primary, Shen, Li, primary, Rao, Xiayu, primary, Wang, Jing, primary, Zhao, Mei, primary, Kalu, Nene N., primary, Johnson, Faye M., primary, Byers, Lauren A., primary, Heymach, John, primary, Hittelman, Walter N., primary, Udayakumar, Durga, primary, Pandita, Raj K., primary, Pandita, Tej K., primary, Pickering, Curtis R., primary, Redwood, Abena B., primary, Piwnica-Worms, Helen, primary, Schlacher, Katharina, primary, Frederick, Mitchell J., primary, and Myers, Jeffrey N., primary

Published
2023
Full Text
View/download PDF

165. Extended supplementary procedures from CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Author

Gadhikar, Mayur A., primary, Zhang, Jiexin, primary, Shen, Li, primary, Rao, Xiayu, primary, Wang, Jing, primary, Zhao, Mei, primary, Kalu, Nene N., primary, Johnson, Faye M., primary, Byers, Lauren A., primary, Heymach, John, primary, Hittelman, Walter N., primary, Udayakumar, Durga, primary, Pandita, Raj K., primary, Pandita, Tej K., primary, Pickering, Curtis R., primary, Redwood, Abena B., primary, Piwnica-Worms, Helen, primary, Schlacher, Katharina, primary, Frederick, Mitchell J., primary, and Myers, Jeffrey N., primary

Published
2023
Full Text
View/download PDF

166. Supplementary tables from Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Author

Shah, Pooja A., primary, Sambandam, Vaishnavi, primary, Fernandez, Anne M., primary, Zhao, Hongyun, primary, Mazumdar, Tuhina, primary, Shen, Li, primary, Wang, Qi, primary, Ahmed, Kazi M., primary, Ghosh, Soma, primary, Frederick, Mitchell J., primary, Wang, Jing, primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

167. Supplementary Tables 1-14 from Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

Author

Gay, Carl M., primary, Tong, Pan, primary, Cardnell, Robert J., primary, Sen, Triparna, primary, Su, Xiao, primary, Ma, Jun, primary, Bara, Rasha O., primary, Johnson, Faye M., primary, Wakefield, Chris, primary, Heymach, John V., primary, Wang, Jing, primary, and Byers, Lauren A., primary

Published
2023
Full Text
View/download PDF

168. Supplementary Figure from Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection

Author

Le, Xiuning, primary, Gleber-Netto, Frederico O., primary, Rubin, M. Laura, primary, Qing, Yun, primary, Du, Robyn, primary, Kies, Merrill, primary, Blumenschein, George, primary, Lu, Charles, primary, Johnson, Faye M., primary, Bell, Diana, primary, Lewis, Jeff, primary, Zhang, Jiexin, primary, Feng, Lei, primary, Wilson, Kaye, primary, Marcelo-Lewis, Kathrina, primary, Wang, Jing, primary, Ginsberg, Lawrence, primary, Gillison, Maura, primary, Lee, J. Jack, primary, Meric-Berstam, Funda, primary, Mills, Gordon B., primary, Myers, Jeffrey N., primary, and Pickering, Curtis R., primary

Published
2023
Full Text
View/download PDF

169. Supplementary Figures from Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Author

Shah, Pooja A., primary, Sambandam, Vaishnavi, primary, Fernandez, Anne M., primary, Zhao, Hongyun, primary, Mazumdar, Tuhina, primary, Shen, Li, primary, Wang, Qi, primary, Ahmed, Kazi M., primary, Ghosh, Soma, primary, Frederick, Mitchell J., primary, Wang, Jing, primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

172. Supplementary Data from Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection

Author

Le, Xiuning, primary, Gleber-Netto, Frederico O., primary, Rubin, M. Laura, primary, Qing, Yun, primary, Du, Robyn, primary, Kies, Merrill, primary, Blumenschein, George, primary, Lu, Charles, primary, Johnson, Faye M., primary, Bell, Diana, primary, Lewis, Jeff, primary, Zhang, Jiexin, primary, Feng, Lei, primary, Wilson, Kaye, primary, Marcelo-Lewis, Kathrina, primary, Wang, Jing, primary, Ginsberg, Lawrence, primary, Gillison, Maura, primary, Lee, J. Jack, primary, Meric-Berstam, Funda, primary, Mills, Gordon B., primary, Myers, Jeffrey N., primary, and Pickering, Curtis R., primary

Published
2023
Full Text
View/download PDF

173. Supplementary Tables from Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8+ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results

Author

Ferrarotto, Renata, primary, Bell, Diana, primary, Rubin, Maria L., primary, Hutcheson, Katherine A., primary, Johnson, Jason M., primary, Goepfert, Ryan P., primary, Phan, Jack, primary, Elamin, Yasir Y., primary, Torman, Danice K., primary, Warneke, Carla L., primary, Hessel, Amy C., primary, Garden, Adam S., primary, Myers, Jeffrey N., primary, Johnson, Faye M., primary, Lee, J. Jack, primary, Sikora, Andrew G., primary, Gillison, Maura L., primary, Glisson, Bonnie S., primary, and Gross, Neil D., primary

Published
2023
Full Text
View/download PDF

174. Supplementary information from Essential Role of DNA Methyltransferase 1–mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors

Author

Min, Hye-Young, primary, Lee, Su-Chan, primary, Woo, Jong Kyu, primary, Jung, Hyun Jin, primary, Park, Kwan Hee, primary, Jeong, Hae Min, primary, Hyun, Seung Yeob, primary, Cho, Jaebeom, primary, Lee, Wooin, primary, Park, Ji Eun, primary, Kwon, So Jung, primary, Lee, Hyo-Jong, primary, Ni, Xiao, primary, Shin, Young Kee, primary, Johnson, Faye M., primary, Duvic, Madeleine, primary, and Lee, Ho-Young, primary

Published
2023
Full Text
View/download PDF

175. Supplementary Figure Legends from Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Author

Tanaka, Noriaki, primary, Patel, Ameeta A., primary, Wang, Jiping, primary, Frederick, Mitchell J., primary, Kalu, Nene N., primary, Zhao, Mei, primary, Fitzgerald, Alison L., primary, Xie, Tong-xin, primary, Silver, Natalie L., primary, Caulin, Carlos, primary, Zhou, Ge, primary, Skinner, Heath D., primary, Johnson, Faye M., primary, Myers, Jeffrey N., primary, and Osman, Abdullah A., primary

Published
2023
Full Text
View/download PDF

176. Supplementary Figures 1-5 from Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

Author

Gay, Carl M., primary, Tong, Pan, primary, Cardnell, Robert J., primary, Sen, Triparna, primary, Su, Xiao, primary, Ma, Jun, primary, Bara, Rasha O., primary, Johnson, Faye M., primary, Wakefield, Chris, primary, Heymach, John V., primary, Wang, Jing, primary, and Byers, Lauren A., primary

Published
2023
Full Text
View/download PDF

177. Supplemental Figure 2 from Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Author

Ferrarotto, Renata, primary, Goonatilake, Ruchitha, primary, Young Yoo, Suk, primary, Tong, Pan, primary, Giri, Uma, primary, Peng, Shaohua, primary, Minna, John, primary, Girard, Luc, primary, Wang, Yuehong, primary, Wang, Liguang, primary, Li, Lerong, primary, Diao, Lixia, primary, Peng, David H., primary, Gibbons, Don L., primary, Glisson, Bonnie S., primary, Heymach, John V., primary, Wang, Jing, primary, Byers, Lauren A., primary, and Johnson, Faye M., primary

Published
2023
Full Text
View/download PDF

178. Functional profiling of theToxoplasmagenome during acute mouse infection

Author

Giuliano, Christopher J., primary, Wei, Kenneth J., additional, Harling, Faye M., additional, Waldman, Benjamin S., additional, Farringer, Madeline A., additional, Boydston, Elizabeth A., additional, Lan, Tammy C. T., additional, Thomas, Raina W., additional, Herneisen, Alice L., additional, Sanderlin, Allen G., additional, Coppens, Isabelle, additional, Dvorin, Jeffrey D., additional, and Lourido, Sebastian, additional

Published
2023
Full Text
View/download PDF

180. ePOCT+ and the medAL-suite: Development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low- and middle-income countries.

Author

Tan, R., Cobuccio, L., Beynon, F., Levine, G.A., Vaezipour, N., Luwanda, L.B., Mangu, C., Vonlanthen, A., Santis, O. De, Salim, N., Manji, K., Naburi, H., Chirande, L., Matata, L., Bulongeleje, M., Moshiro, R., Miheso, A., Arimi, P., Ndiaye, O., Faye, M., Thiongane, A., Awasthi, S., Sharma, K., Kumar, G., Maat, J.S. van de, Kulinkina, A., Rwandarwacu, V., Dusengumuremyi, T., Nkuranga, J.B., Rusingiza, E., Tuyisenge, L., Hartley, M.A., Faivre, V., Thabard, J., Keitel, K., D'Acremont, V., Tan, R., Cobuccio, L., Beynon, F., Levine, G.A., Vaezipour, N., Luwanda, L.B., Mangu, C., Vonlanthen, A., Santis, O. De, Salim, N., Manji, K., Naburi, H., Chirande, L., Matata, L., Bulongeleje, M., Moshiro, R., Miheso, A., Arimi, P., Ndiaye, O., Faye, M., Thiongane, A., Awasthi, S., Sharma, K., Kumar, G., Maat, J.S. van de, Kulinkina, A., Rwandarwacu, V., Dusengumuremyi, T., Nkuranga, J.B., Rusingiza, E., Tuyisenge, L., Hartley, M.A., Faivre, V., Thabard, J., Keitel, K., and D'Acremont, V.

Abstract

01 januari 2023, Item does not contain fulltext, Electronic clinical decision support algorithms (CDSAs) have been developed to address high childhood mortality and inappropriate antibiotic prescription by helping clinicians adhere to guidelines. Previously identified challenges of CDSAs include their limited scope, usability, and outdated clinical content. To address these challenges we developed ePOCT+, a CDSA for the care of pediatric outpatients in low- and middle-income settings, and the medical algorithm suite (medAL-suite), a software for the creation and execution of CDSAs. Following the principles of digital development, we aim to describe the process and lessons learnt from the development of ePOCT+ and the medAL-suite. In particular, this work outlines the systematic integrative development process in the design and implementation of these tools required to meet the needs of clinicians to improve uptake and quality of care. We considered the feasibility, acceptability and reliability of clinical signs and symptoms, as well as the diagnostic and prognostic performance of predictors. To assure clinical validity, and appropriateness for the country of implementation the algorithm underwent numerous reviews by clinical experts and health authorities from the implementing countries. The digitalization process involved the creation of medAL-creator, a digital platform which allows clinicians without IT programming skills to easily create the algorithms, and medAL-reader the mobile health (mHealth) application used by clinicians during the consultation. Extensive feasibility tests were done with feedback from end-users of multiple countries to improve the clinical algorithm and medAL-reader software. We hope that the development framework used for developing ePOCT+ will help support the development of other CDSAs, and that the open-source medAL-suite will enable others to easily and independently implement them. Further clinical validation studies are underway in Tanzania, Rwanda, Kenya, Senegal, and India.

Published
2023

181. REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors

Author

Massachusetts Institute of Technology. Department of Biology, Vassel, Faye M., Laverty, Daniel J., Bian, Ke, Piett, Cortt G., Hemann, Michael T., Walker, Graham C., Nagel, Zachary D., Massachusetts Institute of Technology. Department of Biology, Vassel, Faye M., Laverty, Daniel J., Bian, Ke, Piett, Cortt G., Hemann, Michael T., Walker, Graham C., and Nagel, Zachary D.

Abstract

Rev7 is a regulatory protein with roles in translesion synthesis (TLS), double strand break (DSB) repair, replication fork protection, and cell cycle regulation. Rev7 forms a homodimer in vitro using its HORMA (Hop, Rev7, Mad2) domain; however, the functional importance of Rev7 dimerization has been incompletely understood. We analyzed the functional properties of cells expressing either wild-type mouse Rev7 or Rev7K44A/R124A/A135D, a mutant that cannot dimerize. The expression of wild-type Rev7, but not the mutant, rescued the sensitivity of Rev7−/− cells to X-rays and several alkylating agents and reversed the olaparib resistance phenotype of Rev7−/− cells. Using a novel fluorescent host-cell reactivation assay, we found that Rev7K44A/R124A/A135D is unable to promote gap-filling TLS opposite an abasic site analog. The Rev7 dimerization interface is also required for shieldin function, as both Rev7−/− cells and Rev7−/− cells expressing Rev7K44A/R124A/A135D exhibit decreased proficiency in rejoining some types of double strand breaks, as well as increased homologous recombination. Interestingly, Rev7K44A/R124A/A135D retains some function in cell cycle regulation, as it maintains an interaction with Ras-related nuclear protein (Ran) and partially rescues the formation of micronuclei. The mutant Rev7 also rescues the G2/M accumulation observed in Rev7−/− cells but does not affect progression through mitosis following nocodazole release. We conclude that while Rev7 dimerization is required for its roles in TLS, DSB repair, and regulation of the anaphase promoting complex, dimerization is at least partially dispensable for promoting mitotic spindle assembly through its interaction with Ran.

Published
2023

182. Achieving Real-World Saturated Hydraulic Conductivity: Practical and Theoretical Findings from Using an Exponential One-Phase Decay Model

Author

Keïta, A. Zorom, M. Faye, M. D. Damba, D. D. Konaté, Y. Hayde, L. G. Lidon, B. and Keïta, A. Zorom, M. Faye, M. D. Damba, D. D. Konaté, Y. Hayde, L. G. Lidon, B.

Abstract

Obtaining accurate values of saturated hydraulic conductivity (Ksat) is very important for managing all natural or artificial processes involving water flow into soils. Double-ring infiltration (DRI) is one of the easiest-to-work-with techniques commonly used for Ksat determination. Unfortunately, when improperly used, it leads to important variations and inaccurate results. This study was designed to investigate the necessary conditions to reach the true-value or real-world saturated hydraulic conductivity (Ksat-real-world) in the field. For this purpose, the effects of two factors—namely, the measured infiltration data type (cumulative, instant rate, and average rate) and the related non-linear regression equation type—were analyzed. Measurements with DRI were performed with samples from 106 locations in three West African countries, namely, Burkina Faso, Mali, and Cote d’Ivoire. The soils were composed of loam, sandy loam, and sandy clay loam. The results show that when infiltration rates are used rather than cumulative infiltration non-linear regression curves, the variability between the measured Ksat and the real-world saturated hydraulic conductivity (Ksat-real-world) could reach from 2.2% to 58.8%. This variability was caused by the approximate amplification—according to the procedure used—of time-increment measurement errors. Extending the test duration to more than 4 h, especially when clay soils were involved, and using the exponential one-phase decay non-linear regression of the cumulative infiltration data based on a clear measurement protocol provided the Ksat values that were closest to Ksat-real-world.

Published
2023
Full Text
View/download PDF

186. Supplementary Fig. 2. from Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2

Author

Ethan Dmitrovsky, Sarah J. Freemantle, Duane A. Compton, Faye M. Johnson, Masanori Kawakami, Xi Liu, David Sekula, Lisa Maria Mustachio, Kristina Godek, Bernardo Orr, Shanhu Hu, and Alexey V. Danilov

Abstract

Movie video files of a) H1299 and b) HOP62 cells were treated with 25 or 50 nM dinaciclib and continuously imaged as described in the Methods.

Published
2023

187. Supplementary figure 3 from A Comprehensive Evaluation of Biomarkers Predictive of Response to PI3K Inhibitors and of Resistance Mechanisms in Head and Neck Squamous Cell Carcinoma

Author

Faye M. Johnson, Bonnie S. Glisson, Jeffrey N. Myers, John V. Heymach, Katherine Stemke-Hale, You-Hong Fan, Lixia Diao, Shaohua Peng, Gordon B. Mills, Patrick Kwok Shing Ng, Lauren A. Byers, and Tuhina Mazumdar

Abstract

Supplementary figure 3. Correlation of PI3K mutation, amplification, PI3K score, and mTOR score with sensitivity to GDC0941

Published
2023

189. Supplementary Table 4 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion

Author

Faye M. Johnson, John V. Heymach, John D. Minna, Luc Girard, Scott M. Lippman, Ignacio I. Wistuba, Banibrata Sen, Li Zhang, Shaohua Peng, and Pierre Saintigny

Abstract

PDF file, 77K, Multicovariate Cox model fitted to estimate the effect of age, gender, stage, institution and EphA4 on time to event endpoint, for overall survival.

Published
2023

190. Supplementary Tables legend from Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Author

Andres McAllister, Murali Ramachandra, Faye M. Johnson, Courtney Nicholas, Olivier Michielin, Vincent Zoete, Michel Aguet, Marc Lang, Peter Traxler, Silvano Brienza, Yogeshwar Bachhav, Stefania Rigotti, Samiulla Dhodheri, Sivapriya Marappan, Saumitra Sengupta, Girish Daginakatte, Shankar J. Shetty, Raghuveer Ramachandra, Antoine Attinger, Anne Vaslin Chessex, and Maximilien Murone

Abstract

Legend for Supplementary Tables:1,2,3,4

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results