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151. Screening and topical decolonization of preoperative nasal Staphylococcus aureus carriers to reduce the incidence of postoperative infections after lung cancer surgery: a propensity matched study.

Author

Fourdrain, Alex, Bouabdallah, Ilies, Gust, Lucile, Cassir, Nadim, Brioude, Geoffrey, Falcoz, Pierre-Emmanuel, Alifano, Marco, Rochais, Jean-Philippe Le, D'Annoville, Thomas, Trousse, Delphine, Loundou, Anderson, Leone, Marc, Papazian, Laurent, Thomas, Pascal Alexandre, and D'Journo, Xavier Benoit

Published
2020
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152. Parsimonious Eurolung risk models to predict cardiopulmonary morbidity and mortality following anatomic lung resections: an updated analysis from the European Society of Thoracic Surgeons database.

Author

Brunelli, Alessandro, Cicconi, Silvia, Decaluwe, Herbert, Szanto, Zalan, and Falcoz, Pierre Emmanuel

Subjects
PARSIMONIOUS models, LUNGS, MORTALITY, SURGEONS, DISEASES
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES To develop a simplified version of the Eurolung risk model to predict cardiopulmonary morbidity and 30-day mortality after lung resection from the ESTS database. METHODS A total of 82 383 lung resections (63 681 lobectomies, 3617 bilobectomies, 7667 pneumonectomies and 7418 segmentectomies) recorded in the ESTS database (January 2007–December 2018) were analysed. Multiple imputations with chained equations were performed on the predictors included in the original Eurolung models. Stepwise selection was then applied for determining the best logistic model. To develop the parsimonious models, different models were tested eliminating variables one by one starting from the less significant. The models' prediction power was evaluated estimating area under curve (AUC) with the 10-fold cross-validation technique. RESULTS Cardiopulmonary morbidity model (Eurolung1): the best parsimonious Eurolung1 model contains 5 variables. The logit of the parsimonious Eurolung1 model was as follows: −2.852 + 0.021 × age + 0.472 × male −0.015 × ppoFEV1 + 0.662×thoracotomy + 0.324 × extended resection. Pooled AUC is 0.710 [95% confidence interval (CI) 0.677–0.743]. Mortality model (Eurolung2): the best parsimonious model contains 6 variables. The logit of the parsimonious Eurolung2 model was as follows: −6.350 + 0.047 × age + 0.889 × male −0.055 × BMI −0.010 × ppoFEV1 + 0.892 × thoracotomy + 0.983 × pneumonectomy. Pooled AUC is 0.737 (95% CI 0.702–0.770). An aggregate parsimonious Eurolung2 was also generated by repeating the logistic regression after categorization of the numeric variables. Patients were grouped into 7 risk classes showing incremental risk of mortality (P  < 0.0001). CONCLUSIONS We were able to develop simplified and updated versions of the Eurolung risk models retaining the predictive ability of the full original models. They represent a more user-friendly tool designed to inform the multidisciplinary discussion and shared decision-making process of lung resection candidates. [ABSTRACT FROM AUTHOR]

Published
2020
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153. Venous thromboembolism prophylaxis in thoracic surgery patients: an international survey.

Author

Shargall, Yaron, Brunelli, Alessandro, Murthy, Sudish, Schneider, Laura, Minervini, Fabrizio, Bertolaccini, Luca, Agzarian, John, Linkins, Lori-Ann, Kestenholz, Peter, Li, Hui, Rocco, Gaetano, Girard, Philippe, Venuta, Federico, Samama, Marc, Scarci, Marco, Anraku, Masaki, Falcoz, Pierre-Emmanuel, Kirk, Alan, Solli, Piergiorgio, and Hofstetter, Wayne

Subjects
THORACIC surgery, PATIENT surveys, DENTAL prophylaxis, PREVENTIVE medicine, THORACIC surgeons, CARDIOVASCULAR surgery
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Venous thromboembolic events (VTE) after thoracic surgery (TS) can be prevented with mechanical and chemical prophylaxis. Unlike other surgical specialties, TS lacks evidence-based guidelines. In the process of developing these guidelines, an understanding of the current prophylaxis methods practiced internationally is necessary and is described in this article. METHODS A 26-item survey was distributed to members of the European Society of Thoracic Surgeons (ESTS), American Association of Thoracic Surgery (AATS), Japanese Association for Chest Surgery (JACS) and Chinese Society for Thoracic and Cardiovascular Surgery (CSTCS) electronically or in person. Participants were asked to report their current prophylaxis selection, timing of initiation and duration of prophylaxis, perceived risk factors and the presence and adherence to institutional VTE guidelines for patients undergoing TS for malignancies. RESULTS In total, 1613 surgeons anonymously completed the survey with an overall 36% response rate. Respondents were senior surgeons working in large academic hospitals (≥70%, respectively). More than 83.5% of ESTS, AATS and JACS respondents report formal TS thromboprophylaxis protocols in their institutions, but 53% of CSTCS members report not having such a protocol. The regions varied in the approaches utilized for VTE prophylaxis, the timing of initiation perioperatively and the use and type of extended prophylaxis. Respondents reported that multiple risk factors and sources of information impact their VTE prophylaxis decision-making processes, and these factors vastly diverge regionally. CONCLUSIONS There is little agreement internationally on the optimal approach to thromboprophylaxis in the TS population, and guidelines will be helpful and vastly welcomed. [ABSTRACT FROM AUTHOR]

Published
2020
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156. How to set up a database?—a five-step process

Author

Brembilla, Alice, primary, Martin, Bérenger, additional, Parmentier, Anne-Laure, additional, Desmarets, Maxime, additional, Falcoz, Pierre-Emmanuel, additional, Puyraveau, Marc, additional, and Mauny, Frédéric, additional

Published
2018
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158. Anti-tumour effect of low molecular weight heparin in localised lung cancer: a phase III clinical trial

Author

Meyer, Guy, primary, Besse, Benjamin, additional, Doubre, Hélène, additional, Charles-Nelson, Anaïs, additional, Aquilanti, Sandro, additional, Izadifar, Armine, additional, Azarian, Reza, additional, Monnet, Isabelle, additional, Lamour, Corinne, additional, Descourt, Renaud, additional, Oliviero, Gérard, additional, Taillade, Laurent, additional, Chouaid, Christos, additional, Giraud, Frederique, additional, Falcoz, Pierre-Emmanuel, additional, Revel, Marie-Pierre, additional, Westeel, Virginie, additional, Dixmier, Adrien, additional, Tredaniel, Jean, additional, Dehette, Stéphanie, additional, Decroisette, Chantal, additional, Prevost, Alain, additional, Pichon, Eric, additional, Fabre, Elizabeth, additional, Soria, Jean-Charles, additional, Friard, Sylvie, additional, Stern, Jean-Baptiste, additional, Jabot, Laurence, additional, Dennewald, Georges, additional, Pavy, Gérard, additional, Petitpretz, Patrick, additional, Tourani, Jean-Marc, additional, Alifano, Marco, additional, Chatellier, Gilles, additional, and Girard, Philippe, additional

Published
2018
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159. The Society for Translational Medicine: indications and methods of percutaneous transthoracic needle biopsy for diagnosis of lung cancer

Author

Zhou, Qinghua, primary, Dong, Jingsi, additional, He, Jie, additional, Liu, Deruo, additional, Tian, David H., additional, Gao, Shugeng, additional, Li, Shanqing, additional, Liu, Lunxu, additional, He, Jianxing, additional, Huang, Yunchao, additional, Xu, Shidong, additional, Mao, Weimin, additional, Tan, Qunyou, additional, Chen, Chun, additional, Li, Xiaofei, additional, Zhang, Zhu, additional, Jiang, Gening, additional, Xu, Lin, additional, Zhang, Lanjun, additional, Fu, Jianhua, additional, Li, Hui, additional, Wang, Qun, additional, Tan, Lijie, additional, Li, Danqing, additional, Zhou, Qinghua, additional, Fu, Xiangning, additional, Jiang, Zhongmin, additional, Chen, Haiquan, additional, Fang, Wentao, additional, Zhang, Xun, additional, Li, Yin, additional, Tong, Ti, additional, Yu, Zhentao, additional, Liu, Yongyu, additional, Zhi, Xiuyi, additional, Yan, Tiansheng, additional, Zhang, Xingyi, additional, Casal, Roberto F., additional, Pompeo, Eugenio, additional, Carretta, Angelo, additional, Riquet, Marc, additional, Rena, Ottavio, additional, Falcoz, Pierre-Emmanuel, additional, Saji, Hisashi, additional, Khan, Ali Zamir, additional, Danguilan, Jose Luis, additional, Gonzalez-Rivas, Diego, additional, Guibert, Nicolas, additional, Zhu, Chengchu, additional, and Shen, Jianfei, additional

Published
2018
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161. SNAI 2andTWIST 1in lymph node progression in early stages of NSCLC patients

Author

Emprou, Camille, primary, Le Van Quyen, Pauline, additional, Jégu, Jérémie, additional, Prim, Nathalie, additional, Weingertner, Noëlle, additional, Guérin, Eric, additional, Pencreach, Erwan, additional, Legrain, Michèle, additional, Voegeli, Anne‐Claire, additional, Leduc, Charlotte, additional, Mennecier, Bertrand, additional, Falcoz, Pierre‐Emmanuel, additional, Olland, Anne, additional, Santelmo, Nicolas, additional, Quoix, Elisabeth, additional, Massard, Gilbert, additional, Guenot, Dominique, additional, Chenard, Marie‐Pierre, additional, and Beau‐Faller, Michèle, additional

Published
2018
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167. European guidelines on structure and qualification of general thoracic surgery

Author

Brunelli, Alessandro, Falcoz, Pierre Emmanuel, D'Amico, Thomas, Hansen, Henrik, Lim, Eric, Massard, Gilbert, Rice, Thomas W., Rocco, Gaetano, Thomas, Pascal, Van Raemdonck, Dirk, Congregado, Miguel, Decaluwe, Herbert, Grodzki, Tomasz, Lerut, Toni, Molnar, Thomas, Salati, Michele, Scarci, Marco, Van Schil, Paul, Varela, Gonzalo, Venuta, Federico, Melfi, Franca, Gebitekin, Cengiz, Kuzdzal, Jaroslaw, Leschber, Gunda, Opitz, Isabelle, Papagiannopoulos, Kostas, Patterson, Alec, Ruffini, Enrico, Klepetko, Walter, Toker, Alper, Brunelli, Alessandro, Falcoz, Pierre Emmanuel, D'Amico, Thomas, Hansen, Henrik, Lim, Eric, Massard, Gilbert, Rice, Thomas W., Rocco, Gaetano, Thomas, Pascal, Van Raemdonck, Dirk, Congregado, Miguel, Decaluwe, Herbert, Grodzki, Tomasz, Lerut, Toni, Molnar, Thomas, Salati, Michele, Scarci, Marco, Van Schil, Paul, Varela, Gonzalo, Venuta, Federico, Melfi, Franca, Gebitekin, Cengiz, Kuzdzal, Jaroslaw, Leschber, Gunda, Opitz, Isabelle, Papagiannopoulos, Kostas, Patterson, Alec, Ruffini, Enrico, Klepetko, Walter, and Toker, Alper

Abstract

OBJECTIVE To update the recommendations for the structural characteristics of general thoracic surgery (GTS) in Europe in order to provide a document that can be used as a guide for harmonizing the general thoracic surgical practice in Europe. METHODS A task force was created to set the structural, procedural and qualification characteristics of a European GTS unit. These criteria were endorsed by the Executive Committee of the European Society of Thoracic Surgeons and by the Thoracic Domain of the European Association for Cardio-Thoracic Surgery and were validated by the European Board of Thoracic Surgery at European Union of Medical Specialists. RESULTS Criteria regarding definition and scope of GTS, structure and qualification of GTS unit, training and education and recommendations for subjects of particular interest (lung transplant, oesophageal surgery, minimally invasive thoracic surgery, quality surveillance) were developed. CONCLUSIONS This document will hopefully represent the first step of a process of revision of the modern thoracic surgeons' curricula, which need to be qualitatively rethought in the setting of the qualification process. The structural criteria highlighted in the present document are meant to help and tackle the challenge of cultural and language barriers as well as of widely varying national training programmes

Published
2017

168. Bilobectomy for lung cancer: contemporary national early morbidity and ă mortality outcomes

Author

Thomas , Pascal A., Falcoz , Pierre-Emmanuel, Bernard , Alain, Le Pimpec-Barthes , Françoise, Jougon , Jacques, Brouchet , Laurent, Massard , Gilbert, Dahan , Marcel, Loundou , Anderson, Grp , EPITHOR, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), CHU Strasbourg, Service de chirurgie thoracique [AP-HP HEGP, Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Unité d'Aide Méthodologique, Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes ( URMITE ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR48, INSB-INSB-Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche en Communications et en Cybernétique de Nantes ( IRCCyN ), Mines Nantes ( Mines Nantes ) -École Centrale de Nantes ( ECN ) -Ecole Polytechnique de l'Université de Nantes ( Polytech Nantes ), Université de Nantes ( UN ) -Université de Nantes ( UN ) -PRES Université Nantes Angers Le Mans ( UNAM ) -Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ), Institut des Maladies Métaboliques et Cardiovasculaires ( I2MC ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier ( UPS ), and Assistance Publique - Hôpitaux de Marseille ( APHM ) -CHU Marseille

Subjects
[ SHS.PSY ] Humanities and Social Sciences/Psychology, [ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [ SHS.ECO ] Humanities and Social Sciences/Economies and finances, [SHS.PSY]Humanities and Social Sciences/Psychology, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Quality
Abstract

23rd European Conference on General Thoracic Surgery, Lisbon, PORTUGAL, ă MAY 31-JUN 03, 2015; International audience; To determine contemporary early outcomes associated with bilobectomy for ă lung cancer and to identify their predictors using a nationally ă representative general thoracic surgery database. ă A total of 1831 patients, who underwent elective bilobectomy for primary ă lung cancer between 1 January 2004 and 31 December 2013, were selected. ă Logistic regression analysis was performed on variables for major ă adverse events. ă There were 670 upper and 1161 lower bilobectomies. Video-assisted ă thoracic surgery was seldom performed (2%). Induction therapy and ă extended resection were performed in 293 (16%) and 279 patients ă (15.2%), respectively. Operative mortality was 4.8% (upper: ă 4.5%/lower: 5%; P = 0.62), and significantly higher following extended ă procedures when compared with standard bilobectomy (4.3 vs 7.5%; P = ă 0.013). Pulmonary complication rate was 21.1%. Bronchial fistula ă occurred in 46 patients (2.5%) and pleural space complications in 296 ă (16.2%). Their respective incidence rates were significantly higher ă following lower than upper bilobectomy (3.5 vs 0.7%; P < 0.001 and 17.8 ă vs 13.3%; P = 0.007). At multivariate analysis, extended procedures ă [odds ratio (OR), 2.3; 95% confidence interval (CI), 1.03-5.31; P = ă 0.04], ASA scores of 3 or greater (OR, 2.02; 95% CI, 1.33-3.07; P < ă 0.001) and World Health Organization performance status 2 or greater ă (OR, 1.47; 95% CI, 1.01-2.13; P = 0.04) were risk predictors of ă mortality. Female gender (OR, 0.39; 95% CI, 0.19-0.80; P = 0.01), ă highest body mass index (BMI) values (OR, 0.91; 95% CI, 0.86-0.96; P = ă 0.001) and recent years of surgery (OR, 0.91; 95% CI, 0.84-0.99; P = ă 0.02) were protective. Predictors of bronchial fistula were male gender, ă lowest BMI values, lower bilobectomy and longest operative times. Male ă gender, lowest BMI values and longest operative times were also ă predictors of pulmonary complications, together with highest ASA scores ă and lowest forced expiratory volume in 1 s values. ă Risks related to lower bilobectomy lie halfway between those reported ă for lobectomy and pneumonectomy. Additional surgical measures to prevent ă pleural space complications and bronchial fistula should be encouraged ă with this operation. In contrast, upper bilobectomy shares more or less ă the same hazards as lobectomy.

Published
2016

169. Video-assisted thoracoscopic surgery versus open lobectomy for primary non-small-cell lung cancer. A propensity-matched analysis of outcome from the European Society of Thoracic Surgeon database

Author

Falcoz, Pierre-Emmanuel, Puyraveau, Marc, Thomas, Pascal-Alexandre, Decaluwe, Herbert, Hã¼rtgen, Martin, Petersen, René Horsleben, Hansen, Henrik, Brunelli, Alessandro, Van Raemdonck, Dirk, Dahan, Marcel, Rocco, Gaetano, Varela, Gonzalo, Salaty, Michele, Ruffini, Enrico, Filosso, Pierluigi, Scarci, Marco, Bille, Andrea, D'Journo, Xavier Benoit, Szanto, Zalan, Venuta, Federico, Horsleben, Renã©, Schmidt, Thomas, Piwkowski, Cezary, Gossot, Dominique, Siebenga, Jan, CHU Strasbourg, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes ( URMITE ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR48, INSB-INSB-Centre National de la Recherche Scientifique ( CNRS ), CHU Marseille, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Databases, Factual, medicine.medical_treatment, Atelectasis, 030204 cardiovascular system & hematology, computer.software_genre, surgery, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Carcinoma, Non-Small-Cell Lung, middle aged, Thoracotomy, humans, Aged, 80 and over, medicine.diagnostic_test, Database, Thoracic Surgery, Video-Assisted, Incidence (epidemiology), adult, General Medicine, 3. Good health, [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, aged, female, Anesthesia, Video-assisted thoracoscopic surgery, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, lobectomy, carcinoma non-small-cell lung, databases factual, matched-pair analysis, lung neoplasms, lung cancer, video-assisted thoracoscopic surgery, aged 80 and over, incidence, length of stay, male, pneumonectomy, postoperative complications, propensity score, treatment outcome, thoracic surgery video-assisted, 03 medical and health sciences, McNemar's test, Thoracoscopy, medicine, Lung cancer, business.industry, medicine.disease, Surgery, 030228 respiratory system, Propensity score matching, business, computer
Abstract

22nd European Conference on General Thoracic Surgery, Copenhagen, DENMARK, JUN 15-18, 2014; International audience; Video-assisted thoracoscopic anatomical resections are increasingly used in Europe to manage primary lung cancer. The purpose of this study was to compare the outcome following thoracoscopic versus open lobectomy in case-matched groups of patients from the European Society of Thoracic Surgeon (ESTS) database. All patients having lobectomy as the primary procedure via thoracoscopy [video-assisted thoracoscopic surgery (VATS)-L)] or thoracotomy (TH-L) were identified in the ESTS database (January 2007 to December 2013). A propensity score was constructed using several patients' baseline characteristics. The matching using the propensity score was responsible for the minimization of selection bias. A propensity score-matched analysis was performed to compare the incidence of postoperative major complications (according to the ESTS database definitions) and mortality at hospital discharge between the matched groups. After exclusions, 28 771 patients were identified: 26 050 having thoracotomy and 2721 having thoracoscopy. Propensity score yielded two well-matched groups of 2721 patients. Numeric variables were compared by Student's t-tests and categorical variables were compared by McNemar's tests. Compared with TH-L, VATS-L was associated with a lower incidence of total complications [n = 792 (29.1%) vs 863 (31.7%), P = 0.0357], major cardiopulmonary complications [n = 316 (15.9%) vs 435 (19.6%), P = 0.0094], atelectasis requiring bronchoscopy [n = 65 (2.4%) vs 150 (5.5%), P < 0.0001], initial ventilation > 48 h [n = 18 (0.7%) vs 38 (1.4%), P = 0.0075] and wound infection [n = 6 (0.2%) vs 17 (0.6%), P = 0.0218]. There was no difference in the incidence of postoperative atrial fibrillation between the two groups (P = 0.14). Postoperative hospital stay was 2 days shorter in the VATS-L patients (mean: 7.8 vs 9.8 days; P = 0.0003). In terms of outcome at hospital discharge, there were 27 deaths in the VATS-L group (1%) versus 50 in the TH-L group (1.9%, P = 0.0201). Data from the ESTS database confirmed that lobectomy performed through VATS is associated with a lower incidence of complications compared with thoracotomy.

Published
2016

170. Low Accuracy of Computed Tomography and Positron Emission Tomography to Detect Lung and Lymph Node Metastases of Colorectal Cancer

Author

Guerrera, Francesco, primary, Renaud, Stéphane, additional, Schaeffer, Mickaël, additional, Nigra, Victor, additional, Solidoro, Paolo, additional, Santelmo, Nicola, additional, Filosso, Pier Luigi, additional, Falcoz, Pierre-Emmanuel, additional, Ruffini, Enrico, additional, Oliaro, Alberto, additional, and Massard, Gilbert, additional

Published
2017
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171. The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy

Author

Gao, Shugeng, primary, Zhang, Zhongheng, additional, Aragón, Javier, additional, Brunelli, Alessandro, additional, Cassivi, Stephen, additional, Chai, Ying, additional, Chen, Chang, additional, Chen, Chun, additional, Chen, Gang, additional, Chen, Haiquan, additional, Chen, Jin-Shing, additional, Cooke, David Tom, additional, Downs, John B., additional, Falcoz, Pierre-Emmanuel, additional, Fang, Wentao, additional, Filosso, Pier Luigi, additional, Fu, Xiangning, additional, Force, Seth D., additional, Garutti, Martínez I., additional, Gonzalez-Rivas, Diego, additional, Gossot, Dominique, additional, Hansen, Henrik Jessen, additional, He, Jianxing, additional, He, Jie, additional, Holbek, Bo Laksáfoss, additional, Hu, Jian, additional, Huang, Yunchao, additional, Ibrahim, Mohsen, additional, Imperatori, Andrea, additional, Ismail, Mahmoud, additional, Jiang, Gening, additional, Jiang, Hongjing, additional, Jiang, Zhongmin, additional, Kim, Hyun Koo, additional, Li, Danqing, additional, Li, Gaofeng, additional, Li, Hui, additional, Li, Qiang, additional, Li, Xiaofei, additional, Li, Yin, additional, Li, Zhijun, additional, Lim, Eric, additional, Liu, Chia-Chuan, additional, Liu, Deruo, additional, Liu, Lunxu, additional, Liu, Yongyi, additional, Lobdell, Kevin W., additional, Ma, Haitao, additional, Mao, Weimin, additional, Mao, Yousheng, additional, Mou, Juwei, additional, Ng, Calvin Sze Hang, additional, Novoa, Nuria M., additional, Petersen, René H., additional, Oizumi, Hiroyuki, additional, Papagiannopoulos, Kostas, additional, Pompili, Cecilia, additional, Qiao, Guibin, additional, Refai, Majed, additional, Rocco, Gaetano, additional, Ruffini, Erico, additional, Salati, Michele, additional, Seguin-Givelet, Agathe, additional, Sihoe, Alan Dart Loon, additional, Tan, Lijie, additional, Tan, Qunyou, additional, Tong, Tang, additional, Tsakiridis, Kosmas, additional, Venuta, Federico, additional, Veronesi, Giulia, additional, Villamizar, Nestor, additional, Wang, Haidong, additional, Wang, Qun, additional, Wang, Ruwen, additional, Wang, Shumin, additional, Wright, Gavin M., additional, Xie, Deyao, additional, Xue, Qi, additional, Xue, Tao, additional, Xu, Lin, additional, Xu, Shidong, additional, Xu, Songtao, additional, Yan, Tiansheng, additional, Yu, Fenglei, additional, Yu, Zhentao, additional, Zhang, Chunfang, additional, Zhang, Lanjun, additional, Zhang, Tao, additional, Zhang, Xun, additional, Zhao, Xiaojing, additional, Zhao, Xuewei, additional, Zhi, Xiuyi, additional, and Zhou, Qinghua, additional

Published
2017
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173. Medicoeconomic analysis of lobectomy using thoracoscopy versus thoracotomy for lung cancer: a study protocol for a multicentre randomised controlled trial (Lungsco01)

Author

Pagès, Pierre-Benoit, primary, Abou Hanna, Halim, additional, Bertaux, Anne-Claire, additional, Serge Aho, Ludwig Serge, additional, Magdaleinat, Pierre, additional, Baste, Jean-Marc, additional, Filaire, Marc, additional, de Latour, Richard, additional, Assouad, Jalal, additional, Tronc, François, additional, Jayle, Christophe, additional, Mouroux, Jérome, additional, Thomas, Pascal-Alexandre, additional, Falcoz, Pierre-Emmanuel, additional, Marty-Ané, Charles-Henri, additional, and Bernard, Alain, additional

Published
2017
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174. Corrigendum to ‘European risk models for morbidity (EuroLung1) and mortality (EuroLung2) to predict outcome following anatomic lung resections: an analysis from the European Society of Thoracic Surgeons database’ [Eur J Cardiothorac Surg 2017;51:490-497]†

Author

Brunelli, Alessandro, primary, Salati, Michele, additional, Rocco, Gaetano, additional, Varela, Gonzalo, additional, Raemdonck, Dirk Van, additional, Decaluwe, Herbert, additional, and Falcoz, Pierre Emmanuel, additional

Published
2017
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179. Bronchial complications after lung transplantation are associated with primary lung graft dysfunction and surgical technique

Author

Olland, Anne, primary, Reeb, Jérémie, additional, Puyraveau, Marc, additional, Hirschi, Sandrine, additional, Seitlinger, Joseph, additional, Santelmo, Nicola, additional, Collange, Olivier, additional, Mertes, Paul-Michel, additional, Kessler, Romain, additional, Falcoz, Pierre-Emmanuel, additional, and Massard, Gilbert, additional

Published
2017
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180. Early and Late Atrial Arrhythmias After Lung Transplantation ― Incidence, Predictive Factors and Impact on Mortality ―

Author

Jesel, Laurence, primary, Barraud, Jérémie, additional, Lim, Han S., additional, Marzak, Halim, additional, Messas, Nathan, additional, Hirschi, Sandrine, additional, Santelmo, Nicola, additional, Olland, Anne, additional, Falcoz, Pierre Emmanuel, additional, Massard, Gilbert, additional, Kindo, Michel, additional, Ohlmann, Patrick, additional, Chauvin, Michel, additional, Morel, Olivier, additional, and Kessler, Romain, additional

Published
2017
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181. Air leak: the Achilles tendon of lung resection surgery.

Author

Silva, Joao Santos and Falcoz, Pierre-Emmanuel

Subjects
*LUNG surgery, *SURGICAL excision, *ACHILLES tendon, *VIDEO-assisted thoracic surgery, *DISEASE risk factors, *THORACIC surgery
Abstract

In conclusion, this article may provide valuable data to improve the everyday clinical practice of any thoracic surgery centre by providing a low-cost technique that may reduce the negative impact of prolonged air leaks in the postoperative period of lung resection surgery. Nonpneumonectomy lung resection surgery always has had air leaks as its most significant limitation. Keywords: Air leaks; Prevention; Lung resection surgery EN Air leaks Prevention Lung resection surgery 1 2 2 06/06/23 20230501 NES 230501 Hironori Ishibashi I et al. i [[1]] present a manuscript on a novel method to avoid cough and prolonged air leak in the postoperative period after lung resection surgery. [Extracted from the article]

Published
2023
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182. Epidermal growth factor receptor mutations are linked to skip N2 lymph node metastasis in resected non-small-cell lung cancer adenocarcinomas†

Author

Guerrera, Francesco, primary, Renaud, Stéphane, additional, Tabbó, Fabrizio, additional, Voegeli’, Anne-Claire, additional, Filosso, Pier Luigi, additional, Legrain, Michèle, additional, Boita, Monica, additional, Schaeffer, Mickaël, additional, Beau-Faller, Michèle, additional, Ruffini, Enrico, additional, Falcoz, Pierre-Emmanuel, additional, Inghirami, Giorgio, additional, Oliaro, Alberto, additional, and Massard, Gilbert, additional

Published
2016
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184. Prognostic value of neutrophil to lymphocyte ratio in lung metastasectomy for colorectal cancer.

Author

Renaud, Stéphane, Seitlinger, Joseph, St-Pierre, David, Garfinkle, Richard, Lawati, Yaseen Al, Guerrera, Francesco, Ruffini, Enrico, Falcoz, Pierre-Emmanuel, Massard, Gilbert, Ferri, Lorenzo, and Spicer, Jonathan

Subjects
GENETIC mutation, COLORECTAL cancer, LYMPHOCYTE count, RECEIVER operating characteristic curves, LYMPHOCYTES, LUNGS
Abstract

View large Download slide View large Download slide OBJECTIVES Neutrophil to lymphocyte ratio (NLR) has been shown to be a promising biomarker in several cancers. Prognostic biomarkers are still needed to define good candidates for lung metastasectomy for colorectal cancer. We aimed to evaluate the role of NLR. METHODS Data from 574 patients who underwent lung metastasectomy for colorectal cancer in 3 departments of thoracic surgery from 2004 to 2014 were retrospectively reviewed. Overall survival (OS) and the time to pulmonary recurrence (TTPR) were the main end points. RESULTS Correlations between NLR and OS (R 2 = 0.53), and NLR and TTPR (R 2 = 0.389) were significant (P  < 0.0001 for both), with corresponding Pearson R of −0.728 (P  < 0.0001) and −0.624 (P  < 0.0001), respectively. A receiver operating characteristic curve analysis highlighted an NLR cut-off value of 4.05 as the best predictor of OS and TTPR. NLR ≤4.05 was observed in 238 patients (41.4%). In the univariable analysis, the median OS was 117 months for patients with NLR ≤4.05 and decreased to 40 months for patients with NLR >4.05 (P  < 0.0001). The median TTPR reached 52 months in case of NLR ≤4.05 and decreased to 12 months in patients with NLR >4.05. In the multivariable analysis, NLR ≤4.05 remained an independent favourable prognostic factor on both OS [hazard ratio [HR] 0.29, 95% confidence interval (CI) 0.167–0.503; P  < 0.0001] and TTPR (HR 0.346, 95% CI 0.221–0.54; P  < 0.0001). Significant correlations between NLR >4.05 and KRAS (Cramer's V  = 0.241, P  < 0.0001) and BRAF (Cramer's V  = 0.153, P  = 0.003) mutations were observed. CONCLUSIONS NLR is a simple and powerful predictor of outcomes in patients undergoing pulmonary metastasectomy for colorectal cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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185. Rôles de l’inflammation et de l’apoptose dans la perturbation du dialogue cœur-poumon : applications particulières à la mort cérébrale

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - Faculté de médecine et médecine dentaire, Rondelet, Benoit, Falcoz, Pierre-Emmanuel, Grégoire, Vincent, Mc Entee, Kathleen, Naeije, Robert, Poncelet, Alain, Pilette, Charles, De Backer, Daniel, Van Der Linden, Philippe, Van Raemdonck, Dirk, Belhaj, Asmae, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - Faculté de médecine et médecine dentaire, Rondelet, Benoit, Falcoz, Pierre-Emmanuel, Grégoire, Vincent, Mc Entee, Kathleen, Naeije, Robert, Poncelet, Alain, Pilette, Charles, De Backer, Daniel, Van Der Linden, Philippe, Van Raemdonck, Dirk, and Belhaj, Asmae

Abstract

Brain death is associated with heart dysfunction and acute lung injury. We investigated the involvement of inflammation and apoptosis in three animal models of right ventricle dysfunction associated with pulmonary hypertension. We developed a new brain-death model reproducing the conditions of a brain hemorrhage. In this model, we studied the pathobiological and pathophysiological mechanisms involved in these dysfunctions and using methylprednisolone pretreatment. Brain death is associated with right ventricular dysfunction and neurogenic pulmonary edema with a strong link between these dysfunctions and activation of inflammatory and apoptotic process. The functional entity “right ventricle - lung” seems particularly affected by brain death. Corticosteroids prevent these disturbances by a vasodilatory effect and partial control of inflammation and apoptosis., (MED - Sciences médicales) -- UCL, 2016

Published
2016

186. Rôles de l'inflammation et de l'apoptose dans la perturbation du dialogue coeur-poumon :applications particulières à la mort cérébrale.

Author

Rondelet, Benoît, McEntee, Kathleen, Naeije, Robert, Grégoire, Vincent, De Backer, Daniel, Van Der Linden, Philippe, Poncelet, A., Pilette, C, Van Raemdonck, Dirk, Falcoz, Pierre-Emmanuel F P-E, Belhaj, Asmae, Rondelet, Benoît, McEntee, Kathleen, Naeije, Robert, Grégoire, Vincent, De Backer, Daniel, Van Der Linden, Philippe, Poncelet, A., Pilette, C, Van Raemdonck, Dirk, Falcoz, Pierre-Emmanuel F P-E, and Belhaj, Asmae

Abstract

La mort cérébrale est associée à une dysfonction cardiaque globale et à des lésions pulmonaires aiguës. Nous avons étudié l’implication de l’inflammation et de l’apoptose dans trois modèles de dysfonction cardiaque droite associée à de l’hypertension pulmonaire. Nous avons développé un nouveau modèle de mort cérébrale mimant une hémorragie cérébrale. Dans ce modèle, nous avons étudié les mécanismes pathobiologiques et pathophysiologiques impliqués dans ces dysfonctions et en utilisant le methylprednisolone en prétraitement. La mort cérébrale est associée à une dysfonction ventriculaire droite et à un œdème pulmonaire neurogénique avec un lien étroit entre ces dysfonctions et l’activation de processus inflammatoires et apoptotiques. L’entité fonctionnelle « ventricule droit-poumon » semble particulièrement touchée par la mort cérébrale. Les corticoïdes préviennent ces perturbations par un effet vasodilatateur et par un contrôle partiel des voies inflammatoires et apoptotiques., Doctorat en Sciences médicales (Médecine), info:eu-repo/semantics/nonPublished

Published
2016

187. KRAS exon 2 codon 13 mutation is associated with a better prognosis than codon 12 mutation following lung metastasectomy in colorectal cancer

Author

Renaud, Stéphane, primary, Guerrera, Francesco, additional, Seitlinger, Joseph, additional, Costardi, Lorena, additional, Schaeffer, Mickaël, additional, Romain, Benoit, additional, Mossetti, Claudio, additional, Claire-Voegeli, Anne, additional, Filosso, Pier Luigi, additional, Legrain, Michèle, additional, Ruffini, Enrico, additional, Falcoz, Pierre-Emmanuel, additional, Oliaro, Alberto, additional, and Massard, Gilbert, additional

Published
2016
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188. Microparticles: A new insight into lung primary graft dysfunction?

Author

Olland, Anne, primary, Reeb, Jérémie, additional, Leclerq, Alexandre, additional, Renaud-Picard, Benjamin, additional, Falcoz, Pierre-Emmanuel, additional, Kessler, Romain, additional, Schini-Kerth, Valérie, additional, Kessler, Laurence, additional, Toti, Florence, additional, and Massard, Gilbert, additional

Published
2016
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190. Perioperative bevacizumab improves survival following lung metastasectomy for colorectal cancer in patients harbouringv-Ki-ras2 Kirsten rat sarcoma viral oncogene homologueexon 2 codon 12 mutations†

Author

Renaud, Stéphane, primary, Schaeffer, Mickaël, additional, Falcoz, Pierre-Emmanuel, additional, Seitlinger, Joseph, additional, Romain, Benoit, additional, Voegeli, Anne-Claire, additional, Legrain, Michèle, additional, Reeb, Jérémie, additional, Santelmo, Nicola, additional, Rohr, Serge, additional, Brigand, Cécile, additional, Olland, Anne, additional, Guenot, Dominique, additional, and Massard, Gilbert, additional

Published
2016
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194. Epidermal growth factor receptor and v-Ki-ras2 Kirsten rat sarcoma viral oncogen homologue-specific amino acid substitutions are associated with different histopathological prognostic factors in resected non-small-cell lung cancer

Author

Seitlinger, Joseph, primary, Renaud, Stéphane, additional, Falcoz, Pierre-Emmanuel, additional, Schaeffer, Mickaël, additional, Olland, Anne, additional, Reeb, Jérémie, additional, Santelmo, Nicola, additional, Legrain, Michèle, additional, Voegeli, Anne-Claire, additional, Weingertner, Noëlle, additional, Chenard, Marie-Pierre, additional, Beau-Faller, Michèle, additional, and Massard, Gilbert, additional

Published
2016
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199. Reply to Riquetet al.

Author

Renaud, Stéphane, primary, Garelli, Elena, additional, Falcoz, Pierre-Emmanuel, additional, and Massard, Gilbert, additional

Published
2016
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