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546 results on '"Fabbri, L. M."'

153. Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease.

Author

Begh, B., Hall, I. P., Parker, S. G., Moffatt, M. F., Wardlaw, A., Connolly, M. J., Fabbri, L. M., Ruse, C., and Sayers, I.

Subjects
GENETIC polymorphisms, GENETICS of asthma, OBSTRUCTIVE lung diseases, INTERLEUKIN-13, NUCLEOTIDES, GENES, GENETICS
Abstract

To cite this article: Beghé B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri LM, Ruse C, Sayers I. Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 2010; 65: 474–481. Background: Asthma and chronic obstructive pulmonary disease (COPD) are chronic respiratory diseases involving an interaction between genetic and environmental factors. Interleukin-13 (IL13) has been suggested to have a role in both asthma and COPD. We investigated whether single nucleotide polymorphisms (SNPs) in the IL13 pathway may contribute to the susceptibility and severity of asthma and COPD in adults. Methods: Twelve SNPs in IL13 pathway genes – IL4, IL13, IL4RA, IL13RA1, IL13RA2 and STAT6– were genotyped in subjects with asthma ( n = 299) and in subjects with COPD or healthy smokers ( n = 992). Genetic association was evaluated using genotype and allele models for asthma severity, atopy phenotypes and COPD susceptibility. Linear regression was used to determine the effects of polymorphism on baseline lung function (FEV1, FEV1/FVC). Results: In asthmatics, three IL13 SNPs – rs1881457(–1512), rs1800925(–1111) and rs20541(R130Q) – were associated with atopy risk. One SNP in IL4RA1 [rs1805010(I75V)] was associated with asthma severity, and several IL13 SNPs showed borderline significance. IL13 SNPs rs1881457(–1512) and rs1800925(–1111) were associated with better FEV1 and FEV1/FVC in asthmatics. IL13 SNPs rs2066960(intron 1), rs20541(R130Q) and rs1295685(exon 4) were associated with COPD risk and lower baseline lung function in the recessive model. In females, but not in males, rs2250747 of the IL13RA1 gene was associated with COPD and lower FEV1. Conclusion: These data suggest that IL13 SNPs (promoter and coding region) and, to a lesser extent, IL4RA SNPs may contribute to atopy and asthma. We also provide tentative evidence that IL13 SNPs in the coding region may be of significance in COPD susceptibility. [ABSTRACT FROM AUTHOR]

Published
2010
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158. Mechanisms of occupational asthma.

Author

Maestrelli, P., Saetta, M., Mapp, C., and Fabbri, L. M.

Subjects
ASTHMA, OCCUPATIONAL diseases, OBSTRUCTIVE lung diseases, RESPIRATORY allergy, ASTHMATICS, IMMUNITY, INFLAMMATION
Abstract

This article studies mechanisms of occupational asthma. Occupational asthma shares many characteristics with IgE-mediated asthma: in both, the responsible agent is known, and the clinical presentation, the response to inhalation challenge in the laboratory and the response to anti-asthma drugs are all similar. An immunological mechanism does not necessarily imply an IgE-mediated immunity, but possibly also cell-mediated and mixed reactions. Complex cellular and molecular interactions may cause the characteristic airway inflammation observed in asthma.

Published
1997
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159. Ketotifen does not inhibit asthmatic reactions induced by toluene di-isocyanate in sensitized subjects.

Author

Tossin, L., Chiesura-Corona, P., Fabbri, L. M., De Marzo, N., Picotti, G., Crescioli, S., and Mapp, C. E.

Subjects
ASTHMA, KETOTIFEN, ANTIASTHMATIC agents, ANTIHISTAMINES, TOLUENE, ASTHMATICS
Abstract

In order to determine whether treatment with ketotifen inhibits asthmatic reactions induced by toluene di-isocyanate TDI), we studied six sensitized subjects with previously demonstrated dual or late asthmatic reaction after inhalation challenge with TDI. Ketotifen (1 mg b.i.d., orally) or placebo was administered for 7 days to the examined subjects, according to a double-blind, cross-over, placebo-controlled study design. When the subjects were treated with either ketotifen or placebo, FEV1 markedly decreased after exposure to TDI. These results suggest that the anti-asthmatic agent ketotifen is not effective in TDI-induced asthma and suggest that it should not be used in the prophylaxis of asthmatic reactions induced by TDI in sensitized subjects. [ABSTRACT FROM AUTHOR]

Published
1989
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167. Serum-mediated relaxant response to toluene diisocyanate (TDI) in isolated guinea-pig bronchi

Author

BOSCHETTO, P., JOVINE, L., CHITANO, P., MARZO, N. DE, *, M. PLEBANI, ‡, FAGGIAN, D., FABBRI, L. M., and MAPP, C. E.

Abstract

The present study was designed to evaluate whether pre-incubation with serum, obtained from both control and toluene diisocyanate (TDI)-immunized guinea-pigs, modified the contractile response to TDI in isolated guinea-pig bronchial rings. Guinea-pigs were anaesthetized and the main bronchi dissected in two rings. Bronchial rings were incubated with normal or immune serum (100 μ l ml−1for 2 h) and dose-response curves to TDI (0·03–1000 μ

Published
2001
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171. Fatal asthma

Author

Fabbri, L. M. and MARINA SAETTA

Subjects
Risk Factors, Status Asthmaticus, Humans, Bronchi, Asthma
Published
1989

175. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author

Bousquet, J., Farrell, J., Crooks, G., Hellings, P., Bel, E H., Bewick, M., Chavannes, N H., De Sousa, J Correia, Cruz, A A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, A., Aberer, W., Adachi, M., Agusti, A., Akdis, C A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I J., Anto, J M., Arnavielhe, S., Arshad, H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A K., Barbara, C., Bateman, E D., Beghé, B., Kheder, A Ben, Bennoor, K S., Benson, M., Bergmann, K C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L P., Bourret, R., Bousquet, P J., Braido, F., Briggs, A H., Brightling, C E., Brozek, J., Buhl, R., Burney, P G., Bush, A., Caballero-Fonseca, F., Caimmi, D., Calderon, M A., Calverley, P M., Camargos, P A M., Canonica, G W., Camuzat, T., Carlsen, K H., Carr, W., Carriazo, A., Casale, T., Cepeda Sarabia, A M., Chatzi, L., Chen, Y Z., Chiron, R., Chkhartishvili, E., Chuchalin, A G., Chung, K F., Ciprandi, G., Cirule, I., Cox, L., Costa, D J., Custovic, A., Dahl, R., Dahlen, S E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., De Manuel Keenoy, E., Demoly, P., Denburg, J A., Devillier, P., Didier, A., Dinh-Xuan, A T., Djukanovic, R., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S R., Dykewicz, M S., El-Gamal, Y., Emuzyte, R., Fabbri, L M., Fletcher, M., Fiocchi, A., Fink Wagner, A., Fonseca, J., Fokkens, W J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, J., Gemicio?Lu, B., Gereda, J E., González Diaz, S., Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M A., Heaney, L G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J O' B., Howarth, P., Humbert, M., Hyland, M E., Illario, M., Ivancevich, J C., Jardim, J R., Jares, E J., Jeandel, C., Jenkins, C., Johnston, S L., Jonquet, O., Julge, K., Jung, K S., Just, J., Kaidashev, I., Kaitov, M R., Kalayci, O., Kalyoncu, A F., Keil, T., Keith, P K., Klimek, L., Koffi N'Goran, B., Kolek, V., Koppelman, G H., Kowalski, M L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L T T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K., Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M J., Manning, P., Mara, S., Marshall, G D., Masjedi, M R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E O., Menzies-Gow, A., Merk, H., Michel, J P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G M Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Morgan, M., Mösges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T D., O'Hehir, R E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T A., Portejoie, F., Potter, P., Postma, D., Price, D., Rabe, K F., Raciborski, F., Radier Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez Mañas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G K., Schunemann, H J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F E R., Sisul, J C., Skrindo, I., Smit, H A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P J., Sunyer, J., Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A L., Valia, E., Valovirta, E., Van Ganse, E., Van Hage, M., Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, G., Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D Y., Wahn, U., Wickman, M., Williams, D M., Williams, S., Wright, J., Yawn, B P., Yiallouros, P K., Yusuf, O M., Zaidi, A., Zar, H J., Zernotti, M E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.

Subjects
3. Good health
Abstract

Clinical and translational allergy 6, 29 (2016). doi:10.1186/s13601-016-0116-9, Published by BioMed Central, London

176. Chronicity and progression of asthma

Author

Pauwels, R., Holgate, S. T., Buist, Barnes, N., Dahlen, Kian Fan Chung, Barnes, P., Frew, A. J., Pederson, Bousquet, Fabbri, L. M., Magnussen, H., Bai, and Szczeklik

181. Bronchial epithelium and asthma

Author

Allegra, L., Fabbri, L. M., Picotti, G., and Sabrina Mattoli

Subjects
Mucociliary Clearance, Humans, Bronchi, mechanisms, asthma, Asthma, Epithelium
Abstract

The bronchial epithelium has a number of mechanical functions, including mucociliary clearance and protection against noxious agents. It may also modulate the function of the underlying smooth muscle by metabolism and regulation of mediators and the production of relaxant or constrictor substances, and regulate the activation and differentiation of lymphocytes and mast cells by releasing chemotactic factors and cytokines. It is possible that epithelial structural and functional abnormalities may lead via several mechanisms to increased bronchial responsiveness in asthmatic subjects.

182. Expert Opinion - Therapeutic suggestions for reducing the risk of bronchospasm in asthmatics undergoing surgery, flexible bronchoscopy and/or intravascular administration of radiographic contrast media | Expert Opinion - Suggerimenti terapeutici per la riduzione del rischio di broncospasmo in pazienti asmatici da sottoporre ad interventi operatori, fibrobroncoscopia e/o a somministrazione di mezzi di contrasto

Author

Liccardi, G., Antonicelli, L., Canonica, G. W., Del Prato, B., Michele, F., Fabbri, L. M., Gani, F., Lombardi, C., Milanese, M., Paggiaro, P., Passalacqua, G., Salzillo, A., Scavalli, P., Nicola Scichilone, Sposato, B., Siracusa, A., and D Amato, G.

183. Macrolides for chronic asthma

Author

Richeldi, L., Ferrara, G., Fabbri, L. M., and Peter Gibson

Subjects
treatment, Asthma, airway inflammation

186. American thoracic society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias

Author

Travis, W. D., King Jr, T. E., Bateman, E. D., Lynch, D. A., Capron, F., Center, D., Colby, T. V., Cordier, J. -F, Dubois, R. M., Galvin, J., Grenier, P., Hansell, D. M., Hunninghake, G. W., Kitaichi, M., Müller, N. L., Myers, J. L., Nagai, S., Nicholson, A., Raghu, G., Wallaert, B., Brambilla, C. G., Brown, K. K., Cherniaev, A. L., Costabel, U., Coultas, D. B., Davis, G. S., Demedts, M. G., Douglas, W. W., Egan, J., Eklund, A. G., Fabbri, L. M., Henke, C. A., Hubbard, R. B., Inoue, Y., Izumi, T., Jansen, H. M., Johnston, I., Kim, D. S., Khalil, N., Lake, F. R., Lungarella, G., Lynch Iii, J. P., Mapel, D. W., Martinez, F., Matthay, R., Newman, L. S., Noble, P. W., Ohta, K., Olivieri, D., Ortiz, L. A., Poletti, V., Rodriguez-Roisin, R., Rom, W. N., Jay Ryu, Saldiva, P., Sansores, R. H., Schwarz, M. L., Selman, M., Smith, C. M., Tong, Z., Udwadia, Z., Valeyre, D., Wells, A., Wise, R. A., Xaubet, A., Alvarez Fernandez, E., Brambilla, E., Capelozzi, V., Cherniaev, A., Dalquen, P., Dekan, G., Hasleton, P. S., Hogg, J. C., Jambhekar, N. A., Katzenstein, A. -L, Koss, M. N., Matsubara, O., Müller, K. -M, Thunnissen, F. B. J. M., Waldron, J. A., Li, W. -H, Friedman, P. J., Remy-Jardin, M., and Mcloud, T. C.

187. Pathology of bronchial asthma and animal models of asthma

Author

MARINA SAETTA, Fabbri, L. M., Danieli, D., Picotti, G., and Allegra, L.

Subjects
Airway Obstruction, Disease Models, Animal, Dogs, Guinea Pigs, Respiratory System, hyperresponsiveness, asthma, Animals, Humans, Muscle, Smooth, Asthma, Rats
Abstract

We reviewed studies on pathology of status asthmaticus, asymptomatic asthma, and of animal models developed to study the pathogenesis of asthma. In status asthmaticus airway occlusion by mucous plugs, desquamed epithelium, goblet cell hyperplasia, submucosal glands hypertrophy, increased smooth muscle, basal membrane thickening, inflammatory infiltration of the bronchial mucosa are observed, together with focal areas of alveolar wall destruction in lung parenchyma. At variance with active asthma, in which almost invariably inflammatory cells infiltrate the mucosa, only scarce airway inflammation is reported in asthmatics between attacks. The majority of the animal models developed so far have been addressed to investigate the mechanism of the transient hyperreactivity that is associated with exacerbations of asthma, while little information is available on the structure-function relationship on long-lasting hyperresponsiveness.

188. Importance of airway inflammation for hyperresponsiveness induced by ozone

Author

Holtzman, M. J., Fabbri, L. M., Paul O'Byrne, Gold, B. D., Aizawa, H., Walters, E. H., Alpert, S. E., and Nadel, J. A.

Subjects
Aerosols, Mucous Membrane, Neutrophils, Airway Resistance, hyperresponsiveness, ozone-induced, Acetylcholine, airway, Trachea, Leukocyte Count, Dogs, Ozone, Animals, Tracheitis
Abstract

We studied whether ozone-induced airway hyperresponsiveness correlates with the development of airway inflammation in dogs. To assess airway responsiveness, we determined increases in pulmonary resistance produced by delivering acetylcholine aerosol to the airways. To assess airway inflammation, we biopsied the airway mucosa and counted the number of neutrophils present in the epithelium. Airway responsiveness and inflammation were assessed in anesthetized dogs before ozone exposure and then 1 h and 1 wk after ozone (2.1 ppm, 2 h). Airway responsiveness increased markedly at 1 h after ozone and returned to control levels 1 wk later in each of 6 dogs, but it did not change after ozone in another 4 dogs. Furthermore, dogs that became hyperresponsive also developed a marked and reversible increase in the number of neutrophils in the epithelium, whereas dogs that did not become hyperresponsive had no change in the number of neutrophils. For the group of dogs, the level of airway responsiveness before and after ozone exposure correlated closely with the number of epithelial neutrophils. The results suggest that ozone-induced airway hyperresponsiveness may depend on the development of an acute inflammatory response in the airways.

189. Chronic mucosal inflammation

Author

Frew, A. J., Buist, Fabbri, L. M., Laitinen, L. A., Magnussen, H., Barnes, P., Kian Fan Chung, Holgate, S. T., Allegra, Barnes, N., and Bousquet

190. Expert Opinion - Therapeutic suggestions for reducing the risk of bronchospasm in asthmatics undergoing surgery, flexible bronchoscopy and/or intravascular administration of radiographic contrast media,Expert Opinion - Suggerimenti terapeutici per la riduzione del rischio di broncospasmo in pazienti asmatici da sottoporre ad interventi operatori, fibrobroncoscopia e/o a somministrazione di mezzi di contrasto

Author

Liccardi, G., Antonicelli, L., Canonica, G. W., Del Prato, B., Michele, F., Fabbri, L. M., Gani, F., Lombardi, C., Milanese, M., Paggiaro, P., Passalacqua, G., Salzillo, A., Scavalli, P., Scichilone, N., Bruno Sposato, Siracusa, A., and D Amato, G.

192. Chronic inflammation in asthma

Author

Kian Fan Chung, Holgate, S. T., Magnussen, H., Frew, A. J., Buist, Bousquet, Rodriquez-Roisin, Fabbri, L. M., Allegra, Bai, Pauwels, R., Dahlen, and Szczeklik

194. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society

Author

Sterk, P. J., Fabbri, L. M., Quanjer, P. H., Cockcroft, D. W., Paul O'Byrne, Anderson, S. D., Juniper, E. F., and Malo, J. L.

Subjects
Adult, Europe, Male, Reference Values, lung function test, guidelines, Humans, Female, Lung Diseases, Obstructive, Asthma, Bronchial Provocation Tests, Societies, Medical, Respiratory Function Tests

196. Structural aspects of airway inflammation in COPD

Author

Saetta, M., Antonino Di Stefano, Maestrelli, P., Mapp, C. E., Ciaccia, A., and Fabbri, L. M.

Subjects
Chronic Disease, Leukocytes, Mononuclear, Humans, chronic bronchitis, Lung Diseases, Obstructive, Bronchitis, Cell Adhesion Molecules
Abstract

Descriptions of pathology of chronic bronchitis in the past have been mainly focused on mucous gland hypertrophy, since this was considered the morphologic basis of the disease, but more recent studies have suggested a pathogenetic role for airway inflammation in subjects with chronic bronchitis. In the present review, we briefly summarize the results of these latter studies, which describe the nature of airway inflammation and the state of activation of inflammatory cells in the bronchial mucosa of subjects with chronic bronchitis.

200. CFC Phase-Out and the Chiesi Solution.

Author

Huchon, G. and Fabbri, L. M.

Subjects
*PREFACES & forewords, *FORMOTEROL
Abstract

Discusses various reports published within the issue, including one by Bousquet et al. on the efficacy and safety of formoterol-hydrofluoroalkanes.

Published
2005
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