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6,956 results on '"FINE, HOWARD"'

151. 'Intrigue and entertainment value has to be balanced against people's wellbeing'.

Author

Fine, Howard

Subjects
*COMPARATIVE psychology, *PSYCHOLOGICAL techniques, *HUMAN behavior, *VOCATIONAL guidance, *SOCIAL psychology
Abstract

Dr. Howard Fine, a Consultant Clinical Psychologist, discusses his work as a psychologist on various TV productions. He explains that media psychology is not typically taught in traditional psychology courses, but he stumbled upon it by chance. Dr. Fine describes the different stages of a TV project where psychologists may be involved, such as risk assessment during project development and psychological formulation during casting. He emphasizes the importance of balancing entertainment value with the wellbeing of contestants and educating the public about psychology. Dr. Fine also discusses the need for consent and the industry's increasing awareness of mental health and welfare. However, he acknowledges that some programs push participants to their limits and that more research is needed on the impact on contributors and the support required. Dr. Howard Fine, a media psychologist, discusses his work in the television industry and the importance of using media as a tool for education and change. He highlights some of his favorite projects, including "SAS Who Dares Wins" and "Banged Up," which provide unique insights into different experiences and challenges. Dr. Fine emphasizes the need for psychologists to be involved in media to disseminate accurate information and raise awareness about mental health and social issues. He also discusses the risks and responsibilities that come with working in the media industry and the importance of maintaining professional standards. [Extracted from the article]

Published
2024

152. Conflict Abroad Has Local Effect: AID: Firms react to the war raging between Israel, Hamas.

Author

Fine, Howard

Subjects
Israel-Hamas War, 2023- -- Military aspects, Venture capitalists (Persons) -- Military aspects, Armed Forces -- Reserves
Abstract

The Israel-Hamas war may be raging thousands of miles away, but the impact has already touched companies in Los Angeles County. Some local businesses have been indirectly affected by call-ups [...]

Published
2023

153. Renovaro Moves to End Controversy: BIOTECH: Purchases Dutch AI company GEDI Cube.

Author

Fine, Howard

Subjects
Biotechnology, Immunotherapy, Murder, Mediation
Abstract

Century City-based gene and immunotherapy company Renovaro Biosciences is trying to chart a new course to escape controversies surrounding its co-founder and inventor of its main drug platform. This co-founder, [...]

Published
2023

158. CRC Inks 4th Sequestration Deal: ENERGY: Company signs contract with Houston firm.

Author

Fine, Howard

Subjects
Carbon dioxide, Alternative energy sources, California Resources Corp. -- Contracts -- Joint ventures -- International economic relations, Company joint venture, Contract agreement
Abstract

Beach-based oil and gas giant Califorina Resources Corp. is moving quickly on its carbon storage and injection business, signing yet another carbon-sequestration agreement and applying for federal approval to store [...]

Published
2023

159. Molina Versus Medicare: HEALTH CARE: Firm faces $1.6 billion hit to its revenue.

Author

Fine, Howard

Subjects
Health maintenance organizations, Medicare, Health care industry, Molina Healthcare Inc., Health care industry
Abstract

While most companies have welcomed the end of Covid-era emergency measures, the end of one such measure has meant treacherous times for managed health care organizations such as Long Beach-based [...]

Published
2023

160. Report of the Jumpstarting Brain Tumor Drug Development Coalition and FDA clinical trials neuroimaging endpoint workshop (January 30, 2014, Bethesda MD).

Author

Wen, Patrick Y, Cloughesy, Timothy F, Ellingson, Benjamin M, Reardon, David A, Fine, Howard A, Abrey, Lauren, Ballman, Karla, Bendszuz, Martin, Buckner, Jan, Chang, Susan M, Prados, Michael D, Pope, Whitney B, Gregory Sorensen, Alma, van den Bent, Martin, and Yung, Wai-Kwan Alfred

Subjects
Humans, Glioma, Brain Neoplasms, Positron-Emission Tomography, Magnetic Resonance Imaging, Endpoint Determination, Drug Approval, Clinical Trials as Topic, Neuroimaging, Response Evaluation Criteria in Solid Tumors, RANO, brain tumor, endpoints, neuroimaging, workshop, Rare Diseases, Neurosciences, Cancer, Brain Cancer, Brain Disorders, Good Health and Well Being, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

On January 30, 2014, a workshop was held on neuroimaging endpoints in high-grade glioma. This workshop was sponsored by the Jumpstarting Brain Tumor Drug Development Coalition, consisting of the National Brain Tumor Society, the Society for Neuro-Oncology, Accelerate Brain Cancer Cure, and the Musella Foundation for Research and Information, and conducted in collaboration with the Food and Drug Administration. The workshop included neuro-oncologists, neuroradiologists, radiation oncologists, neurosurgeons, biostatisticians, patient advocates, and representatives from industry, clinical research organizations, and the National Cancer Institute. This report summarizes the presentations and discussions of that workshop and the proposals that emerged to improve the Response Assessment in Neuro-Oncology (RANO) criteria and standardize neuroimaging parameters.

Published
2014

161. DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas.

Author

Joon Tae Kim, Se Jung Chris Chang, Haghdel, Arsalan, Ramakrishna, Rohan R., Pannullo, Susan C., Schwartz, Theodore H., Osborne, Joseph R., Magge, Rajiv S., Fine, Howard A., Cisse, Babacar, Stieg, Philip, Lin, Eaton, Roytman, Michelle, Palmer, Joshua D., Karakatsanis, Nicolas A., Pisapia, David, Liechty, Benjamin, Knisely, Jonathan P.S., and Ivanidze, Jana

Published
2024
Full Text
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162. Faricimab Treat-and-Extend for Diabetic Macular Edema

Author

Wong, Tien Y., primary, Haskova, Zdenka, additional, Asik, Kemal, additional, Baumal, Caroline R., additional, Csaky, Karl G., additional, Eter, Nicole, additional, Ives, Jane A., additional, Jaffe, Glenn J., additional, Korobelnik, Jean-François, additional, Lin, Hugh, additional, Murata, Toshinori, additional, Ruamviboonsuk, Paisan, additional, Schlottmann, Patricio G., additional, Seres, András I., additional, Silverman, David, additional, Sun, Xiaodong, additional, Tang, Yannan, additional, Wells, John A., additional, Yoon, Young Hee, additional, Wykoff, Charles C., additional, Aaberg, Thomas, additional, Abbey, Ashkan, additional, Abdulaeva, Elmira, additional, Abengoechea, Santiago, additional, Abraham, Prema, additional, Ach, Thomas, additional, Adams, Serrhel, additional, Adan Civera, Alfredo, additional, Adrean, Sean, additional, Agostini, Hansjurgen, additional, Alam, Suhail, additional, Alezzandrini, Arturo, additional, Alfaro, Virgil, additional, Aliseda, Daniel, additional, Almony, Arghavan, additional, Amat, Pedro, additional, Amini, Payam, additional, Antoszyk, Andrew, additional, Arias, Luis, additional, Asaria, Riaz, additional, Avila, Marcos, additional, Awh, Carl C., additional, Bafalluy, Joaquin, additional, Baker, Carl, additional, Bandello, Francesco, additional, Barakat, Mark, additional, Barraza, Karen, additional, Bator, Gyorgy, additional, Baumal, Caroline, additional, Belfort, Rubens, additional, Bergstrom, Chris, additional, Bertolucci, George, additional, Bochow, Thomas, additional, Bolz, Matthias, additional, Borcz, Emilia, additional, Bordon, Arnaldo, additional, Boyer, David, additional, Bratko, Galina, additional, Brent, Michael, additional, Brown, Jamin, additional, Brown, David M., additional, Budzinskaya, Maria, additional, Buffet, Sylvia, additional, Burgess, Stuart, additional, Burton, Ben, additional, Busquets, Miguel, additional, Cabrera, Francisco, additional, Cagini, Carlo, additional, Calzada, Jorge, additional, Campochiaro, Peter, additional, Carlson, John, additional, Castellarin, Alessandro, additional, Cava, Carlos, additional, Chaikitmongkol, Voraporn, additional, Chan, Clement, additional, Chang, Emmanuel, additional, Chang, Jonathan, additional, Chang, Andrew, additional, Charles, Steve, additional, Chaudhry, Nauman, additional, Chee, Caroline, additional, Chen, Judy, additional, Chen, Fred, additional, Chen, Shih-Jen, additional, Cheong-Leen, Richard, additional, Chiang, Allen, additional, Chittum, Mark, additional, Chow, David, additional, Connolly, Brian, additional, Cornut, Pierre Loic, additional, Csaky, Karl, additional, Danzig, Carl, additional, Das, Arup, additional, Daskalov, Vesselin, additional, Desco, Carmen, additional, Dessouki, Amr, additional, Dickinson, John, additional, Do, Brian, additional, Dollin, Michael, additional, Dugel, Pravin, additional, Dusova, Jaroslava, additional, Eichenbaum, David, additional, Eldem, Bora, additional, Engstrom, Robert, additional, Ernest, Jan, additional, Escobar, Joan Josep, additional, Esposti, Simona, additional, Falk, Naomi, additional, Farkas, Andrej, additional, Feiner, Leonard, additional, Feltgen, Nicolas, additional, Fernandez, Carlos, additional, Fernandez Vega, Alvaro, additional, Ferrone, Philip, additional, Figueira, Joao, additional, Figueroa, Marta, additional, Findl, Oliver, additional, Fine, Howard, additional, Fortun, Jorge, additional, Fox, Gregory M., additional, Foxman, Scott, additional, Framme, Carsten, additional, Fraser-Bell, Samantha, additional, Fu, Arthur, additional, Fukutomi, Akira, additional, Fung, Nicholas, additional, Furno Sola, Federico, additional, Gallego-Pinazo, Roberto, additional, Garcia, Renata, additional, Garcia-Layana, Alfredo, additional, Gawecki, Maciej, additional, George, Sheen, additional, Ghanchi, Faruque, additional, Ghorayeb, Ghassan, additional, Goldberg, Roger, additional, Goldstein, Michaella, additional, Gomes, Nuno, additional, Ulla, Francisco Gomez, additional, Gonzalez, Victor, additional, Greven, Craig, additional, Gupta, Sunil, additional, Guzman, Miguel, additional, Harris, Martin, additional, Hatz, Katja, additional, Hau, Vivienne, additional, Hau, Vincent, additional, Hayashi, Ken, additional, Heier, Jeffrey, additional, Herba, Ewa, additional, Hershberger, Vrinda, additional, Higgins, Patrick, additional, Hirakata, Akito, additional, Ho, Allen, additional, Holekamp, Nancy, additional, Honda, Shigeru, additional, Hsu, Jason, additional, Hu, Allen, additional, Hurcikova, Maria, additional, Ikeda, Yasuhiro, additional, Isernhagen, Ricky, additional, Ito, Yasuki, additional, Jackson, Tim, additional, Jacoby, Rachael, additional, Jafree, Afsar, additional, Javey, Golnaz, additional, Javid, Cameron, additional, Jhaveri, Chirag, additional, Johnson, Mark, additional, Kacerík, Marek, additional, Kaluzny, Jakub, additional, Kampik, Daniel, additional, Kang, Se Woong, additional, Kapoor, Kapil, additional, Karabas, Levent, additional, Kawasaki, Tsutomu, additional, Kerenyi, Agnes, additional, Khanani, Arshad, additional, Khurana, Rahul, additional, Kim, Brian, additional, Kimura, Kazuhiro, additional, Kishino, Genichiro, additional, Kitano, Shigehiko, additional, Klein-Mascia, Kendra, additional, Kokame, Gregg, additional, Korobelnik, Jean Francois, additional, Kulikov, Alexey, additional, Kuriyan, Ajay, additional, Kwong, Henry, additional, Kwun, Robert, additional, Lai, Timothy, additional, Lai, Chi-Chun, additional, Laird, Philip, additional, Lalonde, Laurent, additional, Lanzetta, Paolo, additional, Larsen, Michael, additional, Laugesen, Caroline, additional, Lavinsky, Daniel, additional, Lebreton, Olivier, additional, Lee, Seong, additional, Levy, Jaime, additional, Lipkova, Blandina, additional, Liu, Mimi, additional, Liu, Judy, additional, Lohmann, Chris P., additional, London, Nikolas, additional, Lorenz, Katrin, additional, Lotery, Andrew, additional, Lozano Rechy, David, additional, Lujan, Silvio, additional, Ma, Patrick, additional, Maeno, Takatoshi, additional, Mahmood, Sajjad, additional, Makkouk, Fuad, additional, Malik, Khurram, additional, Marcus, Dennis, additional, Margherio, Alan, additional, Mastropasqua, Leonardo, additional, Maturi, Raj, additional, McCabe, Frank, additional, McKibbin, Martin, additional, Mehta, Hemal, additional, Menon, Geeta, additional, Mentes, Jale, additional, Michalska-Malecka, Katarzyna, additional, Misheva, Aneta, additional, Mitamura, Yoshinori, additional, Mitchell, Paul, additional, Modi, Yasha, additional, Mohamed, Quresh, additional, Montero, Javier, additional, Moore, Jeffrey, additional, Morales Canton, Virgilio, additional, Morori-Katz, Haia, additional, Morugova, Tatiana, additional, Murakami, Tomoaki, additional, Muzyka-Wozniak, Maria, additional, Nardi, Marco, additional, Nemcansky, Jan, additional, Nester-Ostrowska, Kamila, additional, Neto, Julio, additional, Newell, Charles, additional, Nicolo, Massimo, additional, Nielsen, Jared, additional, Noda, Kousuke, additional, Obana, Akira, additional, Ogata, Nahoko, additional, Oh, Hideyasu, additional, Oh, Kean, additional, Ohr, Matthew, additional, Oleksy, Piotr, additional, Oliver, Scott, additional, Olivier, Sebastien, additional, Osher, James, additional, Ozcalışkan, Sehnaz, additional, Ozturk, Banu, additional, Papp, Andras, additional, Park, Kyu Hyung, additional, Parke, D. Wilkin, additional, Parravano, Maria Cristina, additional, Patel, Sugat, additional, Patel, Sunil, additional, Pearce, Ian, additional, Pearlman, Joel, additional, Penha, Fernando, additional, Perente, Irfan, additional, Perkins, Stephen, additional, Pertile, Grazia, additional, Petkova, Iva, additional, Peto, Tunde, additional, Pieramici, Dante, additional, Pollreisz, Andreas, additional, Pongsachareonnont, Pear, additional, Pozdeyeva, Nadezhda, additional, Priglinger, Siegfried, additional, Qureshi, Jawad, additional, Raczynska, Dorota, additional, Rajagopalan, Rajesh, additional, Ramirez Estudillo, Juan, additional, Raskauskas, Paul, additional, Rathod, Rajiv, additional, Razavi, Hessam, additional, Regillo, Carl, additional, Ricci, Federico, additional, Rofagha, Soraya, additional, Romanczak, Dominika, additional, Romanowska-Dixon, Bożena, additional, Rosberger, Daniel, additional, Rosenblatt, Irit, additional, Rosenblatt, Brett, additional, Ross, Adam, additional, Ruiz Moreno, Jose Maria, additional, Salomão, Gustavo, additional, Sandhu, Sukhpal, additional, Sandner, Dirk, additional, Sararols, Laura, additional, Sawada, Osamu, additional, Schadlu, Ramin, additional, Schlottmann, Patricio, additional, Schuart, Claudia, additional, Seitz, Berthold, additional, Seres, András, additional, Sermet, Figen, additional, Shah, Sandeep, additional, Shah, Ankur, additional, Shah, Rohan, additional, Sharma, Sumit, additional, Sheidow, Thomas, additional, Sheth, Veeral, additional, Shimouchi, Akito, additional, Shimura, Masahiko, additional, Sikorski, Bartosz, additional, Silva, Rufino, additional, Singer, Michael, additional, Singerman, Lawrence, additional, Singh, Rishi, additional, Souied, Eric, additional, Spinak, David J., additional, Spital, Georg, additional, Steinle, Nathan, additional, Stern, Jeffrey, additional, Stoller, Glenn, additional, Stoltz, Robert, additional, Stone, Cameron, additional, Stone, Amy, additional, Suan, Eric, additional, Sugimoto, Masahiko, additional, Sugita, Iichiro, additional, Sun, Jennifer, additional, Suner, Ivan, additional, Szalczer, Lajos, additional, Szecsko, Timea, additional, Tabassian, Ali, additional, Tadayoni, Ramin, additional, Takagi, Hitoshi, additional, Takayama, Kei, additional, Taleb, Alexandre, additional, Talks, James, additional, Tan, Gavin, additional, Tanabe, Teruyo, additional, Taylor, Stanford, additional, Thach, Allen, additional, Thompson, John, additional, Tlucek, Paul, additional, Torti, Robert, additional, Tosheva Guneva, Daniela, additional, Toth-Molnar, Edit, additional, Uchiyama, Eduardo, additional, Vajas, Attila, additional, Varma, Deepali, additional, Varsanyi, Balazs, additional, Vassileva, Petja, additional, Vaz-Pereira, Sara, additional, Veith, Miroslav, additional, Vela, Jose Ignacio, additional, Viola, Francesco, additional, Virgili, Gianni, additional, Vogt, Gábor, additional, Vorum, Henrik, additional, Weber, Pamela, additional, Wecke, Thoalf, additional, Wee, Raymond, additional, Weger, Martin, additional, Weishaar, Paul, additional, Wickremasinghe, Sanjeewa, additional, Williams, Thomas Reginald, additional, Williams, Thomas, additional, Williams, Geoff, additional, Wolf, Armin, additional, Wolfe, Jeremy, additional, Wong, James, additional, Wong, David, additional, Wong, Ian, additional, Wong, Robert, additional, Wowra, Bogumil, additional, Wylęgała, Edward, additional, Yang, Chang-Hao, additional, Yasukawa, Tsutomu, additional, Yates, Paul, additional, Yilmaz, Gursel, additional, Yiu, Glenn, additional, Yoreh, Barak, additional, Yoshida, Shigeo, additional, Yu, Hyeong Gon, additional, Yu, Seung Young, additional, Yurieva, Tatiana, additional, Zacharias, Leandro, additional, Zaczek Zakrzewska, Karolina, additional, Zambrano, Alberto, additional, Zatorska, Barbara, additional, Zeolite, Carlos, additional, and Zheutlin, Jeffrey, additional

Published
2023
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163. NIMG-73. RADIOGRAPHIC CHANGES AFTER RADIATION THERAPY IN SUBTOTALLY RESECTED ATYPICAL MENINGIOMAS

Author

Yim, Eunji, primary, Pan, Peter, additional, Ivanidze, Jana, additional, Chiang, Gloria, additional, Pannullo, Susan, additional, Knisely, Jonathan, additional, Brandmaier, Andrew, additional, Fine, Howard, additional, Ramakrishna, Rohan, additional, Schwartz, Theodore, additional, Stieg, Philip, additional, Liechty, Benjamin, additional, Pisapia, David, additional, and Magge, Rajiv, additional

Published
2023
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164. Identification of Molecular Pathways Facilitating Glioma Cell Invasion In Situ

Author

Nevo, Ido, Woolard, Kevin, Cam, Maggie, Li, Aiguo, Webster, Joshua D, Kotliarov, Yuri, Kim, Hong Sug, Ahn, Susie, Walling, Jennifer, Kotliarova, Svetlana, Belova, Galina, Song, Hua, Bailey, Rolanda, Zhang, Wei, and Fine, Howard A

Subjects
Biochemistry and Cell Biology, Biological Sciences, Rare Diseases, Stem Cell Research - Nonembryonic - Human, Brain Cancer, Brain Disorders, Biotechnology, Cancer, Genetics, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Neurosciences, Adult, Animals, Brain Neoplasms, Cell Proliferation, Female, Gene Expression Regulation, Neoplastic, Glioma, Heterografts, Humans, Male, Mice, Mice, SCID, Neoplasm Invasiveness, Neoplasm Proteins, Neoplasm Transplantation, Tumor Microenvironment, General Science & Technology
Abstract

Gliomas are mostly incurable secondary to their diffuse infiltrative nature. Thus, specific therapeutic targeting of invasive glioma cells is an attractive concept. As cells exit the tumor mass and infiltrate brain parenchyma, they closely interact with a changing micro-environmental landscape that sustains tumor cell invasion. In this study, we used a unique microarray profiling approach on a human glioma stem cell (GSC) xenograft model to explore gene expression changes in situ in Invading Glioma Cells (IGCs) compared to tumor core, as well as changes in host cells residing within the infiltrated microenvironment relative to the unaffected cortex. IGCs were found to have reduced expression of genes within the extracellular matrix compartment, and genes involved in cell adhesion, cell polarity and epithelial to mesenchymal transition (EMT) processes. The infiltrated microenvironment showed activation of wound repair and tissue remodeling networks. We confirmed by protein analysis the downregulation of EMT and polarity related genes such as CD44 and PARD3 in IGCs, and EFNB3, a tissue-remodeling agent enriched at the infiltrated microenvironment. OLIG2, a proliferation regulator and glioma progenitor cell marker upregulated in IGCs was found to function in enhancing migration and stemness of GSCs. Overall, our results unveiled a more comprehensive picture of the complex and dynamic cell autonomous and tumor-host interactive pathways of glioma invasion than has been previously demonstrated. This suggests targeting of multiple pathways at the junction of invading tumor and microenvironment as a viable option for glioma therapy.

Published
2014

165. Micro-Environment Causes Reversible Changes in DNA Methylation and mRNA Expression Profiles in Patient-Derived Glioma Stem Cells

Author

Baysan, Mehmet, Woolard, Kevin, Bozdag, Serdar, Riddick, Gregory, Kotliarova, Svetlana, Cam, Margaret C, Belova, Galina I, Ahn, Susie, Zhang, Wei, Song, Hua, Walling, Jennifer, Stevenson, Holly, Meltzer, Paul, and Fine, Howard A

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Rare Diseases, Brain Cancer, Neurosciences, Biotechnology, Cancer, Clinical Research, Brain Disorders, Stem Cell Research, Human Genome, Animals, DNA Methylation, Female, Glioma, Humans, In Vitro Techniques, Mice, Mice, SCID, Neoplastic Stem Cells, Polymorphism, Single Nucleotide, Principal Component Analysis, Prospective Studies, Tumor Cells, Cultured, General Science & Technology
Abstract

In vitro and in vivo models are widely used in cancer research. Characterizing the similarities and differences between a patient's tumor and corresponding in vitro and in vivo models is important for understanding the potential clinical relevance of experimental data generated with these models. Towards this aim, we analyzed the genomic aberrations, DNA methylation and transcriptome profiles of five parental tumors and their matched in vitro isolated glioma stem cell (GSC) lines and xenografts generated from these same GSCs using high-resolution platforms. We observed that the methylation and transcriptome profiles of in vitro GSCs were significantly different from their corresponding xenografts, which were actually more similar to their original parental tumors. This points to the potentially critical role of the brain microenvironment in influencing methylation and transcriptional patterns of GSCs. Consistent with this possibility, ex vivo cultured GSCs isolated from xenografts showed a tendency to return to their initial in vitro states even after a short time in culture, supporting a rapid dynamic adaptation to the in vitro microenvironment. These results show that methylation and transcriptome profiles are highly dependent on the microenvironment and growth in orthotopic sites partially reverse the changes caused by in vitro culturing.

Published
2014

166. ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

Author

Chudnovsky, Yakov, Kim, Dohoon, Zheng, Siyuan, Whyte, Warren A, Bansal, Mukesh, Bray, Mark-Anthony, Gopal, Shuba, Theisen, Matthew A, Bilodeau, Steve, Thiru, Prathapan, Muffat, Julien, Yilmaz, Omer H, Mitalipova, Maya, Woolard, Kevin, Lee, Jeongwu, Nishimura, Riko, Sakata, Nobuo, Fine, Howard A, Carpenter, Anne E, Silver, Serena J, Verhaak, Roel GW, Califano, Andrea, Young, Richard A, Ligon, Keith L, Mellinghoff, Ingo K, Root, David E, Sabatini, David M, Hahn, William C, and Chheda, Milan G

Subjects
Brain Cancer, Neurosciences, Genetics, Cancer, Rare Diseases, Brain Disorders, Animals, Autoantigens, Carcinogenesis, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Glioblastoma, Homeodomain Proteins, Humans, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Mice, Inbred NOD, Protein Binding, Transcription Factors, Transcription, Genetic, Biochemistry and Cell Biology, Medical Physiology
Abstract

Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397 kDa transcription factor. ZFHX4 is required to maintain TIC-associated and normal human neural precursor cell phenotypes in vitro, suggesting that ZFHX4 regulates differentiation, and its suppression increases glioma-free survival in intracranial xenografts. ZFHX4 interacts with CHD4, a core member of the nucleosome remodeling and deacetylase (NuRD) complex. ZFHX4 and CHD4 bind to overlapping sets of genomic loci and control similar gene expression programs. Using expression data derived from GBM patients, we found that ZFHX4 significantly affects CHD4-mediated gene expression perturbations, which defines ZFHX4 as a master regulator of CHD4. These observations define ZFHX4 as a regulatory factor that links the chromatin-remodeling NuRD complex and the GBM TIC state.

Published
2014

172. CRC Goes Big on Carbon: ENERGY: Plans to spend $2.5B over next five years.

Author

Fine, Howard

Subjects
Natural gas -- Planning, Petroleum industry -- International economic relations, Carbon dioxide -- Planning, California Resources Corp. -- International economic relations, Company business planning
Abstract

Oil companies have extracted carbon-based liquids and gases from the earth for well more than a century. But now, some oil companies are spending billions to inject carbon back into [...]

Published
2023

175. GoodRx Demotes Its Co-Founders: HEALTH CARE: Firm brings in interim CEO.

Author

Fine, Howard

Subjects
Internet service providers -- Officials and employees, Drugs -- Prescribing, Chief executive officers, Health care industry -- Officials and employees, Chairpersons, GoDaddy Inc. -- Officials and employees, Health care industry, Internet service provider
Abstract

Santa Monica-based prescription drug comparison price and discount platform GoodRx Holdings Inc. late last month abruptly ousted its co-founders as co-chief executives and brought in an internet tech veteran as [...]

Published
2023

177. Avita Medical Inks Rights Deal: Firm to market Chinese wound-care product

Author

Fine, Howard

Subjects
Wounds and injuries -- Care and treatment, Business, Business, regional
Abstract

Valencia-based Avita Medical Inc., has signed a deal with a unit of a Chinese company to commercialize its wound-treatment product in the United States. Financial terms of the deal with [...]

Published
2024

179. Tetra Tech Celebrates Pair of USAID Contracts The two deals are worth combined value of $58M.

Author

Fine, Howard

Subjects
Administrative agencies, Biological diversity conservation, Environmental monitoring, Economic development -- United States -- Cambodia, Engineering firms -- Contracts, Natural resources -- United States -- Cambodia, Tetra Tech Inc. -- Contracts, Contract agreement
Abstract

Pasadena-based infrastructure and engineering services firm Tetra Tech Inc. has nabbed a pair of contracts worth $58 million from the United States Agency for International Development. On Jan. 4, Tetra [...]

Published
2024

180. The Foothill Gold Line Extension is 81 % Complete The 9.1-mile project comes with a $1.6 billion price tag.

Author

Fine, Howard

Subjects
Construction industry, Engineering firms, Transportation authorities, Light rail transit, Railroads -- Design and construction, Kiewit Corp., Parsons Corp.
Abstract

Construction of the 9.1-mile, $1.6 billion Foothill Gold Line Extension light rail project in the eastern San Gabriel Valley is more than 80% complete, with all the bridge, grade-crossing and [...]

Published
2024

181. Antelope Valley to Add Ambulances: Medical center will lease two dedicated vehicles

Author

Fine, Howard

Subjects
Emergency vehicles, Medical centers, Automobiles -- Contracts, Automobile lease and rental industry, Business, Business, regional
Abstract

Antelope Valley Medical Center in Lancaster is creating its first ambulance fleet to help address a shortage of ambulances in the Antelope Valley region. Officials with the 420-bed medical center [...]

Published
2024

182. Tutor Perini Nabs $81M Contract From University: 400-bed residence hall for Mississippi State

Author

Fine, Howard

Subjects
Tutor Perini Corp. -- Contracts, Construction industry -- Contracts, Contract agreement, Business, Business, regional, Mississippi State University
Abstract

Can you spell Mississippi? Tutor Perini Corp. can. The Sylmar-based infrastructure and construction firm has the Magnolia State to thank for its first contract win announced in the new year. [...]

Published
2024

183. Arcutis Gets FDA Nod for Topical Foam: Company's Zoryve designed to treat seborrheic dermatitis

Author

Fine, Howard

Subjects
United States. Food and Drug Administration, Drug approval, Seborrhea, Business, Business, regional, Zoryve (Medication)
Abstract

Westlake Village-based immuno-dermatology company Arcutis Biotherapeutics Inc. has received approval from the Food and Drug Administration for a topical foam version of its main drug to treat seborrheic dermatitis in [...]

Published
2024

184. Pharmavite Buys Bonafide Health: Female health at center of deal valued at $425M

Author

Fine, Howard

Subjects
Women -- Health aspects, Dietary supplements industry -- Mergers, acquisitions and divestments, Company business management, Company acquisition/merger, Business, Business, regional
Abstract

Pharmavite, a West Hills vitamin and supplement company, has acquired Bonafide Health, a women's health products company based in Harrison, New York, for $425 million. Pharmavite, founded in 1971, is [...]

Published
2024

185. Ontario Enjoys Boost in International Travel Activity AIRPORTS: China Airlines behind jump in passengers.

Author

Fine, Howard

Subjects
Airline passengers -- Traffic, Airlines -- Foreign operations, Airports -- Traffic, Southwest Airlines Co. -- Foreign operations, China Airlines Company Ltd. -- Foreign operations
Abstract

Passenger traffic at the four airports serving Los Angeles Comity continued to rebound toward pre-pandemic levels in November, led in large part by major gains in international traffic. Roughly 7.56 [...]

Published
2024

186. UCLA Cancer Center Wins Grants Funding will be used for cancer detection tech.

Author

Fine, Howard

Subjects
Cancer -- Diagnosis -- Usage -- Technology application, United States. National Cancer Institute -- Technology application, Company financing, Technology application
Abstract

The UCLA Health Jonsson Comprehensive Cancer Center received a couple of shots in the arm last month. First, it was announced that researchers at the center received two grants totaling [...]

Published
2024

187. ImmunityBio Gets $320M Investment The company raised a total of $850 million last year.

Author

Fine, Howard

Subjects
Immunotherapy, Drug approval, Investment companies -- Finance, Company financing
Abstract

Culver City-based immunotherapy company ImmunityBio Inc. has received as much as $320 million in financing from New York private equity firm Oberland Capital Management. The company received $210 million of [...]

Published
2024

191. Cadiz Sets Leadership Transition: Incoming CEO was chief of staff to Schwarzenegger.

Author

Fine, Howard

Subjects
Fruit industry -- Officials and employees, Chief executive officers -- Appointments, resignations and dismissals, Cadiz Inc. -- Officials and employees
Abstract

Downtown-based water infrastructure company Cadiz Inc. has announced a leadership transition effective Jan. 1. Stepping down as chief executive is water and land use attorney Scott Slater, who has led [...]

Published
2023

192. Tetra Tech Nabs Water Contract: Financial terms of the deal were not disclosed.

Author

Fine, Howard

Subjects
Water utilities -- Contracts, Building -- Contracts, Engineering firms -- Contracts, Sewage -- Purification, Tetra Tech Inc. -- Contracts, Contract agreement
Abstract

Pasadena-based infrastructure-services firm Tetra Tech Inc. has received a five-year contract from Ireland's main water utility to support the utility's forthcoming capital investment program. The contract was announced late last [...]

Published
2023

193. Tetra Tech Nabs Contract: INFRASTRUCTURE: Firm won 5-year contract in Ireland.

Author

Fine, Howard

Subjects
Water utilities -- Contracts, Infrastructure (Economics), Building -- Contracts, Contract agreement
Abstract

Pasadena-based infrastructure-services firm Terra Tech Inc. has received a five-year contract from Ireland's main water utility, Uisce Eirearm, to support the utility's forthcomhig capital investment program. The terms of the [...]

Published
2023

195. Amgen Creates New Therapy Line: It's utilizing Horizon's drug development programs

Author

Fine, Howard

Subjects
United States. Food and Drug Administration -- Officials and employees, Amgen Inc. -- Officials and employees, Johnson & Johnson -- Officials and employees, Biotechnology industry -- Officials and employees, Drug approval, Pharmaceutical industry -- Officials and employees, Business, Business, regional, Stelara (Medication)
Abstract

With its long-anticipated acquisition of Horizon Therapeutics wrapped up last month, Thousand Oaks pharma giant Amgen Inc. is incorporating Horizon's drug development programs into a new business line for rare [...]

Published
2023

196. AVMC Gets Peds Director: Medical center named Batish its pediatric medical director

Author

Fine, Howard

Subjects
Medical centers, College teachers -- Appointments, resignations and dismissals, Business, Business, regional
Abstract

Antelope Valley Medical Center in Lancaster has named Suraj Batish as its new pediatric medical director. Batish leads the Antelope Valley's only hospital-based pediatric unit. Batish replaces Lynne Ellison as [...]

Published
2023

197. Miller, Pediatrix Partner Up: They created a children's and women's neonatal network.

Author

Fine, Howard

Subjects
Health care industry -- Officials and employees, Infants (Newborn), Acetaminophen, Pediatrix Medical Group Inc. -- Officials and employees, Health care industry
Abstract

Memorial Care Miller Children's and Women's Hospital in Long Beach and physician services provider Pediatrix Medical Group have partnered to create a children's and women's neonatal network. The network partnership, [...]

Published
2023

200. Firm Repairs 10 Freeway: Freeway sustained fire damage

Author

Fine, Howard

Subjects
Fires, Business, Business, regional
Abstract

Two San Fernando Valley-area companies emerged last week with ties to the 10 Freeway segment south of downtown Los Angeles that was shut down after being damaged in a pallet [...]

Published
2023

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