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”Because at the heart of the apparent conflict between public health concerns and capitalistic interests, market access for pharmaceuticals is largely driven by political considerations, the difference with usual consumer goods being that pharmaceuticals are saving lives or years of life in good health”. If pharmaceutical companies are to innovate, they must be incentivised with prices that reflect the value of their products, and the resources and risks involved in their production. To ensure appropriate access to new drugs and treatments for patients in need around the world, affordability is key. How do we tackle this dilemma? This question is critical for all stakeholders. The development of universal health coverage puts pressure on governments to directly or indirectly control reimbursement and prices of pharmaceuticals, whereas the flow of innovations addressing infectious, chronic, and life-threatening diseases is growing constantly. This book summarizes various global approaches to solving this dilemma and explores new trends. Thanks to the ‘toolbox'proposed by the authors, not only students but also executives from companies, payers, regulators and patients'organizations can benefit from the supporting concepts and methods that favour greater access to pharmaceuticals.

This book explores the potential role of prebiotics, probiotics, and synbiotics in managing various metabolic disorders, chronic diseases, and metabolic syndromes. The initial chapter provides an overview of metabolic disorders, including their classification, symptoms, and underlying causes. Additionally, the chapter discusses the intricate signaling pathways and mechanisms through which prebiotics, probiotics, and synbiotics interact with the human body in relation to type-2 diabetes, obesity, Phenylketonuria, and Hemochromatosis. Additionally, the book highlights the potential impact of probiotics and synbiotics on oxidative stress, inflammation, lipid metabolism, and blood pressure. Furthermore, this book focuses on the gut-brain axis and how synbiotics may influence neurotransmitter metabolism. With an emphasis on the gut-microbiota axis, this book presents a compelling narrative that explores the rationality behind synbiotic use and offers a glimpse into future perspectives for managing metabolic disorders effectively. This book is intended for researchers in the fields of nutraceuticals, nanomedicine, endocrinology, nutrition, gastroenterology, and metabolic medicine who are working in the field of probiotics, prebiotics, and symbiotics for the treatment of metabolic disorders.

This reference book discusses the role of synbiotics in a wide range of disease states, including cardiovascular, reproductive, metabolic, neurodegenerative, gastrointestinal, thrombotic, skin, and inflammatory disorders. It reviews the functions of probiotics in the diagnosis, prevention, or treatment of various disease states. The book further covers improving the targeting efficiency of synbiotics through advanced drug delivery systems such as nanoparticles, microparticles, liposomes, microemulsion, solid lipid nanoparticles, and nano lipid carriers. The chapter addresses the implications of oral and topical delivery of synbiotics in different diseases and presents the safety assessment of synbiotics and clinical trials associated with synbiotics containing drug delivery systems for the treatment of diseases. The book also explores the synergistic welfare of synbiotics nutraceuticals in various conditions such as chronic respiratory diseases, gut health, and neurological functions and examines the toxicological profile, and regulatory aspects of nutraceutical supplements. As such, this book is a valuable resource for academics, research and industry professionals working in Pharmaceutical Sciences, Food Biotechnology, Immunology, and Health Sciences.​

This book is a comprehensive guide on microbiome research, from the fundamentals of to the latest advancements in microbiome-based therapeutics. The initial chapters introduce the concept of the human microbiome delving into the intricate relationship between the human host and its microbiome. The chapter also examines the various tools and techniques used in microbiome research and the role of computational biology in analyzing vast amounts of microbiome data. The subsequent chapters review the role of the microbiome in various health conditions, including metabolic disorders, immunological disorders, gastrointestinal tract disorders, management of cancers, metabolic disorders, and mental health disorders. Towards the end, the book examines the regulatory considerations surrounding microbiome-based therapeutics, and ethical considerations surrounding microbiome-based therapeutics. This book is a comprehensive and cutting-edge guide for researchers, healthcare professionals, and students interested in the field of microbiome research and its potential for transforming healthcare.

This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.

Anomaly Detection and Complex Event Processing over IoT Data Streams: With Application to eHealth and Patient Data Monitoring presents advanced processing techniques for IoT data streams and the anomaly detection algorithms over them. The book brings new advances and generalized techniques for processing IoT data streams, semantic data enrichment with contextual information at Edge, Fog and Cloud as well as complex event processing in IoT applications. The book comprises fundamental models, concepts and algorithms, architectures and technological solutions as well as their application to eHealth. Case studies, such as the bio-metric signals stream processing are presented –the massive amount of raw ECG signals from the sensors are processed dynamically across the data pipeline and classified with modern machine learning approaches including the Hierarchical Temporal Memory and Deep Learning algorithms. The book discusses adaptive solutions to IoT stream processing that can be extended to different use cases from different fields of eHealth, to enable a complex analysis of patient data in a historical, predictive and even prescriptive application scenarios. The book ends with a discussion on ethics, emerging research trends, issues and challenges of IoT data stream processing. - Provides the state-of-the-art in IoT Data Stream Processing, Semantic Data Enrichment, Reasoning and Knowledge - Covers extraction (Anomaly Detection) - Illustrates new, scalable and reliable processing techniques based on IoT stream technologies - Offers applications to new, real-time anomaly detection scenarios in the health domain

The book presents the proceedings of four conferences: The 24th International Conference on Image Processing, Computer Vision, & Pattern Recognition (IPCV'20), The 6th International Conference on Health Informatics and Medical Systems (HIMS'20), The 21st International Conference on Bioinformatics & Computational Biology (BIOCOMP'20), and The 6th International Conference on Biomedical Engineering and Sciences (BIOENG'20). The conferences took place in Las Vegas, NV, USA, July 27-30, 2020, and are part of the larger 2020 World Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE'20), which features 20 major tracks. Authors include academics, researchers, professionals, and students.Presents the proceedings of four conferences as part of the 2020 World Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE'20);Includes the tracks on Image Processing, Computer Vision, & Pattern Recognition, Health Informatics &Medical Systems, Bioinformatics, Computational Biology & Biomedical Engineering;Features papers from IPCV'20, HIMS'20, BIOCOMP'20, and BIOENG'20.

Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. - Provides essential information on the most recent drug delivery systems available - Explains current technology and its applications to drug delivery - Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers

W publikacji podjęto problematykę wykorzystywania informacji związanych ze zdrowiem w marketingu produktów żywnościowych, skupiając się przede wszystkim na oświadczeniach zdrowotnych i żywieniowych umieszczanych na etykietach. Wybór tematu wynikał z jednej strony z rosnącego znaczenia pozacenowych atrybutów produktów żywnościowych, do których zaliczają się dane o właściwościach odżywczych i zdrowotnych, a z drugiej – z luki badawczej w tym obszarze w polskiej literaturze przedmiotu. Monografia może być użyteczna zarówno dla uczonych zajmujących się marketingiem produktów żywnościowych lub naukami o żywności i żywieniu oraz studentów pokrewnych kierunków, jak i dla praktyków zarządzania marketingowego w przedsiębiorstwach przetwórstwa i dystrybucji produktów z segmentu tzw. „zdrowej żywności”.

The Renaissance Diet 2.0 is not a fad. Instead, this hands-on guide presents a sports nutrition approach to eating for fat loss, muscle gain, and enhanced sport performance by incorporating current, comprehensive evidence—setting it apart from all the misinformation on nutrition available today. Within this book, you will read which parts of a diet determine results. Delving into calorie intake, food quality, meal spacing and timing, and supplement use, you will understand how to rank-order each part based on its relative contribution to diet, ensuring that you remain focused and avoid getting needlessly caught up in minute details. Next you will further explore why and how calories matter; how much protein is enough; whether snacking is a good idea or if intermittent fasting is better. Each of these questions and more will be answered, giving you the foundational knowledge to understand diet structure. Finally, you will learn how to design your individual diet by using the given step-by-step guidelines on how to modify your diet as your body adapts. Additional information about hunger management, diet psychology, and long-term diet planning is provided—all to achieve the best results. Also included are special diet considerations for a vegan diet, training multiple times a day, competition day, endurance sports, and women at different life stages, as well as information on the most pervasive diet myths and why they are wrong. By using the knowledge and tools in this book, you are guaranteed to achieve any fat loss, muscle gain, or performance goal. Renaissance Periodization has helped hundreds of thousands of clients across the world reach their fitness goals. Whether you want to lose fat, gain muscle, or improve sports performance, the experts at RP can help get you there. Foreword by Rich Froning.

This new edition of a groundbreaking book, now in two volumes, enables the reader more readily to understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques.

There are many possible causes of pelvic pain in a non-pregnant female patient, and it has been estimated to be responsible for nearly 40% of all visits by female patients to a family doctor and 10% of all referrals to specialist gynecologists. However, the topic of how to investigate and diagnose has been surprisingly neglected in print. This important and much-needed text from internationally respected experts shows how important ultrasound can be as a tool for physicians caring for women's health.

Uma ferramenta indispensável ao estudo da Cirurgia Vascular, Cirurgia Endovascular e Angiologia. Estamos chegando na Quarta Edição da obra Cirurgia Vascular. É de se esperar que uma nova edição seja pensada, esmiuçada e encarada sempre como alguma coisa que se pretende melhor que a edição anterior.Ofoco é o ensino e a melhor maneira de torná-lo mais eficiente e proveitoso. A forma na qual este livro é estruturado visa a proporcionar uma leitura agradável, sem tornar penoso o processo de absorção do conhecimento. Comamudança célere por que passa o mundo em todos os seus aspectos, é imperativo uma adaptação para novas propostas didáticas. Esta nova proposta didática vemda vontade dos editores de procuraremmanter-se alinhados aos novos tempos que correm. Olivro não está organizado por patologia,mas por blocos anatômicos. Emcada bloco, o leitor poderá encontrar tudo o que se refere a esta fração anatômica, ou seja, anatomia, vias de acesso, exames de imagem e outros, além de todas as patologias vasculares que afetemeste segmento. Existemcapítulos que não podem ser enquadrados em blocos anatômicos, ou se referem a todos, e estes ficarão nas rubricas de Capítulos Básicos. Em nossa ótica, o livro-texto continua a representar um utensílio indispensável ao estudo, desde que ele é alicerce, o conhecimento já sedimentado, a partir do qual o leito vai acrescentando o novo, deumaformaorganizada. Os autores

This new edition of a groundbreaking book is now in two volumes, on'Fundamentals, Symptoms, and Conditions‘ on'Reconstructive and Fertility Preserving Surgery and Procedures. From a distinguished editorial team and internationally recognized contributors the text educates surgeons on the techniques and procedures now needed in gynecology, with a special focus on reconstructive vaginal, hysteroscopic, laparoscopic, and laparotomic surgery, including that designed to preserve or enhance fertility. The reader can now more readily understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques. The two volumes contain over 20 new chapters and in the integral ebook, over 140 instructional videos; each chapter has Key Points summarized.

This text provides an overview of venous diseases and focuses on clinical evaluation and management. It is intended to guide the treating physician by summarizing the evidence, giving technical tips, and outlining algorithms for common conditions. A unique feature of this book is clinical pearls given by experts in the field that are highlighted in each chapter. The first section of the book describes the essential anatomy and physiology/pathophysiology. It also includes evaluation of common presentations of venous diseases such as extremity edema and lower extremity ulceration with a summary for work up that includes conditions that can mimic venous diseases. The organization of the book follows the basic pathophysiology of venous disorders with chapters addressing special conditions of common interest such as pelvic congestion syndrome, thoracic outlet syndrome, and May-Thurner syndrome. There is emphasis on novel treatment modalities and emerging technologies through dedicated chapters to anticoagulant agents, emerging modalities to treat superficial venous reflux and venous stent technology. Finally, this book is a melting pot for physicians who have shown dedication and passion to the care of patients with venous disease regardless of specialty and location.The authors are an international panel of vascular experts who trained in vascular surgery, interventional radiology, interventional cardiology, hematology, pulmonology and critical care medicine. Therefore, the book will be of great value to the physicians and trainees in those specialties and to any person interested in developing in depth knowledge of the management of venous diseases.

This handbook offers comprehensive coverage of recent advancements in Big Data technologies and related paradigms. Chapters are authored by international leading experts in the field, and have been reviewed and revised for maximum reader value. The volume consists of twenty-five chapters organized into four main parts. Part one covers the fundamental concepts of Big Data technologies including data curation mechanisms, data models, storage models, programming models and programming platforms. It also dives into the details of implementing Big SQL query engines and big stream processing systems. Part Two focuses on the semantic aspects of Big Data management including data integration and exploratory ad hoc analysis in addition to structured querying and pattern matching techniques. Part Three presents a comprehensive overview of large scale graph processing. It covers the most recent research in large scale graph processing platforms, introducing several scalablegraph querying and mining mechanisms in domains such as social networks. Part Four details novel applications that have been made possible by the rapid emergence of Big Data technologies such as Internet-of-Things (IOT), Cognitive Computing and SCADA Systems. All parts of the book discuss open research problems, including potential opportunities, that have arisen from the rapid progress of Big Data technologies and the associated increasing requirements of application domains. Designed for researchers, IT professionals and graduate students, this book is a timely contribution to the growing Big Data field. Big Data has been recognized as one of leading emerging technologies that will have a major contribution and impact on the various fields of science and varies aspect of the human society over the coming decades. Therefore, the content in this book will be an essential tool to help readers understand the development and future of the field.

This classic resource by Drs. Mitchel P. Goldman, Robert A Weiss, and Jean-Jerome Guex provides highly practical, up-to-date guidance for the effective management of varicose veins and other vascular anomalies. It is an indispensable reference for a wide audience including dermatologists, invasive radiologists, family practitioners, vascular and cosmetic surgeons. Clearly written by global experts, Sclerotherapy, 6th Edition, helps those new to the field to gain a firm understanding of successful techniques, as well as showing seasoned practitioners how to improve and hone their skills with today's best and newest approaches. Case studies and detailed color illustrations offer step-by-step visual guidance. - Covers everything you need to know with a practical approach, from the pathogenesis of varicosities to diagnostic and treatment options, including evidence-based decision making. - Helps you optimize outcomes and improve your surgical, injection, and laser techniques with comprehensive, visual guidance, including coverage of common pitfalls and'tricks of the trade.'- Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Features hot topic coverage of endovenous glue and new endovenous ablation techniques, as well as updated techniques for optimal use of foam sclerotherapy and uses for solutions recently available on the market. - Discusses new concepts for treating areas other than the legs, including rejuvenation of the hands and chest.

This encyclopedia presents important research on dermatological advances. This six set volume includes discussions on the structure and composition of the dermis layer of the skin; the biosynthesis, functions and health benefits of melanin; the genetics, as well as the geographic variation and disorders, of skin pigmentation; the causes, diagnosis and treatment of alopecia, rosacea, candidiasis, cyanosis, psoriasis, and bullous pemphigoid; new research on skin aging; risk factors, protection practices and health effects of sun exposure; skin cancer prevention; the use of sunscreen; skin cancer prevention guidance for schools and youth; and the epidemiology, management and impact on muscle and joint functions of burns.

Dieses Buch ist das erste seiner Art über die weltweit bedeutsamen Rotaviren und die durch sie verursachten Krankheiten und die damit verbundenen Kosten und Belastungen für die Gesellschaft. In dem Buch wird beschrieben, mit welch immensem Aufwand Rotavirus-Schluckimpfstoffe entwickelt und weltweit getestet wurden. Es zeigt sich nunmehr, dass die Rotavirus-Impfung die weitaus wirksamste und sicherste prophylaktische Maßnahme vor Rotavirus-Erkrankungen darstellt. Es ist zu wünschen, dass dieses Buch mit dazu beiträgt, dass die zugelassenen Rotavirus-Impfstoffe auch in Zukunft möglichst vielen Säuglingen zugute kommen. Dieses Buch ist daher nicht nur praktisch tätigen Medizinern (v.a. Kinderärzte, Allgemeinärzte, Impfärzte) und fortgeschrittenen interessierten Medizinstudenten, sondern auch politisch diesbezüglich verantwortlichen Personen (Gesundheitsökonomen, Vertretern der Krankenkassen) sehr zu empfehlen.

A comprehensive compilation of new developments in data linkage methodology The increasing availability of large administrative databases has led to a dramatic rise in the use of data linkage, yet the standard texts on linkage are still those which describe the seminal work from the 1950-60s, with some updates. Linkage and analysis of data across sources remains problematic due to lack of discriminatory and accurate identifiers, missing data and regulatory issues. Recent developments in data linkage methodology have concentrated on bias and analysis of linked data, novel approaches to organising relationships between databases and privacy-preserving linkage. Methodological Developments in Data Linkage brings together a collection of contributions from members of the international data linkage community, covering cutting edge methodology in this field. It presents opportunities and challenges provided by linkage of large and often complex datasets, including analysis problems, legal and security aspects, models for data access and the development of novel research areas. New methods for handling uncertainty in analysis of linked data, solutions for anonymised linkage and alternative models for data collection are also discussed. Key Features: Presents cutting edge methods for a topic of increasing importance to a wide range of research areas, with applications to data linkage systems internationally Covers the essential issues associated with data linkage today Includes examples based on real data linkage systems, highlighting the opportunities, successes and challenges that the increasing availability of linkage data provides Novel approach incorporates technical aspects of both linkage, management and analysis of linked data This book will be of core interest to academics, government employees, data holders, data managers, analysts and statisticians who use administrative data. It will also appeal to researchers in a variety of areas, including epidemiology, biostatistics, social statistics, informatics, policy and public health.

Survey Methodology is becoming a more structured field of research, deserving of more and more academic attention. The SAGE Handbook of Survey Methodology explores both the increasingly scientific endeavour of surveys and their growing complexity, as different data collection modes and information sources are combined. The handbook takes a global approach, with a team of international experts looking at local and national specificities, as well as problems of cross-national, comparative survey research. The chapters are organized into seven major sections, each of which represents a stage in the survey life-cycle: Surveys and Societies Planning a Survey Measurement Sampling Data Collection Preparing Data for Use Assessing and Improving Data Quality The SAGE Handbook of Survey Methodology is a landmark and essential tool for any scholar within the social sciences.

This state-of-the-art volume provides insight into the recent developments in survey research. It covers topics like: survey modes and response effects, bio indicators and paradata, interviewer and survey error, mixed-mode panels, sensitive questions, conducting web surveys and access panels, coping with non-response, and handling missing data. The authors are leading scientists in the field, and discuss the latest methods and challenges with respect to these topics.Each of the book's eight parts starts with a brief chapter that provides an historical context along with an overview of today's most critical survey methods. Chapters in the sections focus on research applications in practice and discuss results from field studies. As such, the book will help researchers design surveys according to today's best practices. The book's website www.survey-methodology.de provides additional information, statistical analyses, tables and figures. An indispensable reference for practicing researchers and methodologists or any professional who uses surveys in their work, this book also serves as a supplement for graduate or upper level-undergraduate courses on survey methods taught in psychology, sociology, education, economics, and business. Although the book focuses on European findings, all of the research is discussed with reference to the entire survey-methodology area, including the US. As such, the insights in this book will apply to surveys conducted around the world.

This handbook covers Electronic Medical Record (EMR) systems, which enable the storage, management, and sharing of massive amounts of demographic, diagnosis, medication, and genomic information. It presents privacy-preserving methods for medical data, ranging from laboratory test results to doctors'comments. The reuse of EMR data can greatly benefit medical science and practice, but must be performed in a privacy-preserving way according to data sharing policies and regulations. Written by world-renowned leaders in this field, each chapter offers a survey of a research direction or a solution to problems in established and emerging research areas. The authors explore scenarios and techniques for facilitating the anonymization of different types of medical data, as well as various data mining tasks. Other chapters present methods for emerging data privacy applications and medical text de-identification, including detailed surveys of deployed systems. A part of the book is devoted to legislative and policy issues, reporting on the US and EU privacy legislation and the cost of privacy breaches in the healthcare domain. This reference is intended for professionals, researchers and advanced-level students interested in safeguarding medical data.

Advances in Dermatology Research presents original research results on the leading edge of dermatology. Each chapter has been carefully selected in an attempt to present substantial advances across a broad spectrum. Some topics discusses in this book include pemphigoid; cyanosis, and acne.

Information acquisition and management has always had a profound impact on societal and organizational progression. However, as computing dramatically advances the level of intelligence associated with management technologies, the breadth of their dispersal, and ultimately the impact of the information itself, the utilization and management of information science and technology also gains profound importance. This change-driven environment creates a critical need for a comprehensive, up-to-date reference encompassing the full range of concepts, issues, methods, technologies, and trends associated with the field. The Encyclopedia of Information Science and Technology, Third Edition is a 10-volume compilation of authoritative, research-based articles contributed by thousands of researchers and experts from all over the world. This discipline-defining encyclopedia will serve research needs in numerous fields that are affected by the rapid pace and substantial impact of technological change. With an emphasis on modern issues and the presentation of potential opportunities, prospective solutions, and future directions in the field, it is a relevant and essential addition to any academic library's reference collection.

Dem in der Frauenarztpraxis häufigen und unspezifischen Symptom Chronischer Unterbauchschmerz liegen oft mehrere Ursachen gleichzeitig zugrunde. Ein multimodaler Therapieansatz ist bei diesem komplexen Beschwerdebild, das häufig eine Herausforderung für den Diagnostiker und Therapeuten gleichermaßen darstellt, in den meisten Fällen sinnvoll.Dieses Buch, geschrieben von klinisch erfahrenen Herausgebern und Autoren, bietet eine hilfreiche Unterstützung bei der Gewichtung der einzelnen pathogenetischen Faktoren und der Differenzialdiagnostik.So finden sich unter anderem Kapitel zu- Endometriose- Reizdarmsyndrom- Uterus myomatosus - Urologischen Ursachen/muskulären BeckenbodenschmerzenDie Säulen der Therapie werden ausführlich erörtert- Diagnosespezifische medikamentöse und operative Maßnahmen- Symptomorientierte multimodale Therapie- Psychosomatische Behandlungsansätze- Selbsthilfe und komplementäre BehandlungsansätzeEin Überblick über die derzeitige Versorgungsrealität in Deutschland rundet das Werk ab.

Chronic Abdominal Pain is a comprehensive resource focused on the management of chronic abdominal pain. Chapters begin with an overview of pain generation, adaptive mechanisms and various diagnostic approaches. A complete range of novel, conservative, minimally invasive and surgical therapeutic options and their proper selection are then discussed along with evidence-based and practical clinical aspects of patient care. Authored by a team of world-renowned physicians and researchers, this definitive guide provides novel algorithms for contemporary treatment of chronic abdominal pain, giving pain medicine clinicians and practitioners the knowledge needed to assess and treat patients with abdominal pain.

This book, written by experts from across the world, provides comprehensive coverage of acne and rosacea, focusing in particular on pathogenesis and treatment but also considering clinical aspects, prognostic factors, and impacts on quality of life. Both standard knowledge and important, clinically relevant insights that have emerged over the past decade are presented with the goal of assisting the reader in understanding these diseases and improving treatment outcome. It is explained how high-level research has recently given rise to a variety of new concepts in etiology and treatment, and emerging trends are also discussed. The book is in a reader-friendly format that highlights core messages with a very practical and clinical focus. Pathogenesis and Treatment of Acne and Rosacea will be an indispensable reference for all physicians who care for patients with acne or rosacea and for scientists working in the field.

Published in association with the Society for Vascular Surgery, Rutherford's Vascular Surgery presents state-of-the-art updates on all aspects of vascular health care. Extensively revised by many new authors to meet the needs of surgeons, interventionalists, and vascular medicine specialists, this medical reference book incorporates medical, endovascular and surgical treatment, as well as diagnostic techniques, decision making and fundamental vascular biology.Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more.View clinical and physical findings and operative techniques more vividly with a full-color layout and images.Get answers you can depend on. Rutherford's delivers the world's most trusted information on all major areas of vascular health care, is written by international experts, and includes up-to-date bibliographies and annotated recommended references.Discover emerging techniques in rapidly advancing topics, with special emphasis on endovascular coverage, vascular imaging, angiography, CT and MRI.Explore brand new chapters on dialysis catheters, renovascular disease, and management of branches during endovascular aneurysm.Stay up-to-date with the latest coverage of endovascular procedures that reflects the changing practices and techniques in vascular surgery.Access videos at Expert Consult.

Over the years, medical informatics has matured into a true scientific discipline. Fundamental and applied aspects are now taught in various fields of health, including medicine, dentistry, pharmacy, nursing and public health. Medical informatics is also often included in the curricula of many other disciplines, including the life sciences, engineering and economics.Medical informatics is a complex and rapidly changing discipline. Relatively few books have been published on the subject, and they rapidly become obsolete. This book is the fruit of a collaborative effort between authors teaching medical informatics in France and others who are conducting research in this field. In addition, an international perspective was pursued, as reflected in the inclusion of various developments and actions in both the USA and Europe.This book is divided into 18 chapters, all of which include learning objectives, recommendations for further reading, exercises and bibliographic references.

The book provides the newest definitive text on the current techniques used in assessing vascular disorders. Readers will receive authoritative information and will be guided through the establishment and accreditation of a vascular laboratory and introduced to the physics of diagnostic testing. The chapters comprehensively explain the use of ultrasound in diagnosing cerebrovascular, renovascular, visceral ischemia and peripheral arterial disease, as well as venous disorders and deep abdominal vascular conditions. The book contains over 300 illustrations, many of them in color. The book will be invaluable to physicians who treat vascular disorders, surgeons, cardiologists, vascular radiologists and the vascular laboratory staff.

Les thérapeutiques endovasculaires veineuses ont toujours constitué « le parent pauvre » de la radiologie interventionnelle. Pourtant par leur fréquence, elles sont lourdes de conséquences autant pour le patient que pour la société : souffrances, invalidité, mortalité et coût socioéconomique. Le domaine est vaste, méconnu et multidisciplinaire ; c'est la raison pour laquelle l'auteur a fait appel aux différents référents de la thérapeutique concernée. Découpé en 31 chapitres, cet ouvrage vous permettra : - d'acquérir des données anatomiques et hémodynamiques très mal connues mais indispensables à une pratique raisonnée, efficace et sécurisée des traitements veineux ; - d'acquérir une culture étiologique et clinique des maladies veineuses pour mieux poser les diagnostics, les indications et accompagner les traitements ; - de découvrir des informations pratiques sur les traitements endovasculaires de manière à améliorer et fiabiliser ces techniques et réduire les complications ; - de dépasser les limites habituelles de certaines thérapeutiques par la promotion de techniques en cours d'expérimentation. Destiné aux radiologues, chirurgiens et médecins vasculaires, ce livre intéressera les étudiants des DIU de ces trois catégories et devrait s'imposer comme une référence indispensable.

Chronic venous insufficiency, manifesting as disabling open leg ulcers, lipodermatosclerosis and severe cutaneous hyperpigmentation is thought to affect five percent of the population over age 80 and a significant proportion, probably greater than one percent, of Western populations under age 65. To date little has been known about how to treat this condition cost-effectively beyond supportive and palliative care. Thus, the most important feature of Chronic Venous Insufficiency is that it describes the interventions which markedly ameliorate, and in some cases cure, the condition. The authoritative text has been skilfully illustrated to show how new methods of endovascular and endoscopic interventions can be integrated with radiologic techniques to correct totally the abnormalities which produce chronic venous insufficiency. Taken as a whole this volume will enable general surgeons, vascular surgeons, dermatologists and interventional radiologists to treat a condition that was, until recently, thought to be untreatable.

For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli­ cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro­ gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the'classic'and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu­ ously hallmark results in reproductive endocrinology worldwide.

Sleeping with a partner is often difficult: many people suffer from sleep disorders, and others have sleep preferences that can disturb their bedmate. This book is for every couple that has found it difficult to share a bed, argued about his snoring or her restless legs, or woken up to the alarm feeling tired and cranky. The authors first explain how sharing a bed affects sleep quality, well-being, and the happiness of the relationship. They then discuss factors that cause couples'sleep disturbances, from individual preferences to gender differences. They describe the connection between personality traits and sleep habits, and they reveal the ways in which age and aging affect our sleep. Most of all, they offer practical advice on how to sleep better with a partner, including getting-ready-for-bed rituals, the emotional and sexual aspects of sharing a bed, and guidelines for allowing children or pets into bed. The book also includes questions for assessing sleep needs and practical suggestions for ending arguments.

Patients with vascular disease offer great challenges to physicians of multiple backgrounds. The rapid improvement in multimodal imaging and the growth of endovascular strategies for treatment of peripheral vascular disease have resulted in an explosion in interest in these patients. But patients and physicians often misdiagnose vascular disease as normal signs of aging, resulting in presentation to specialists at the end stage of the disease process. This textbook, edited by two recognized experts in the field, is designed to offer unique and comprehensive information on the diagnostic approach to and state-of-the-art treatment of arterial and venous diseases. This multispecialty textbook will be a critical addition to the practicing clinician's library.

Rutherford's Vascular Surgery - the most acclaimed comprehensive reference in its field - presents definitive, state-of-the-art guidance on every aspect of vascular health care, equipping you to make the best clinical decisions and optimize outcomes. Extensively revised by many new, international authors - led by Drs. Jack Cronenwett and K. Wayne Johnston - and now published in association with the Society for Vascular Surgery, this 7th Edition provides the authoritative answers that surgeons, interventionalists, and vascular medicine specialists need to provide effective care for vascular surgery patients.Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located.Get answers you can depend on. Now published in association with the Society for Vascular Surgery, Rutherford's delivers the world's most trusted information on all major areas of vascular health care, written by international experts, with up-to-date bibliographies and annotated recommended references. Overcome any clinical challenge with in-depth sections on Fundamental Considerations, Patient Evaluation, Atherosclerotic Risk Factors, Perioperative Care, Bleeding and Clotting, Complications, Venous Disease, Lymphedema, Arteriovenous Anomalies, Hemodialysis Access, Miscellaneous Technique, Grafts and Devices, Cerebrovascular Disease, Lower Extremity Arterial Disease, Upper Extremity Arterial Disease, Arterial Aneurysms, Renal and Mesenteric Disease, and Trauma and Acute Limb Ischemia. Choose the best management option for each patient with discussions of operative, endovascular, and non-operative approaches for vascular conditions. Access the complete contents of Rutherford's Vascular Surgery online at www.expertconsult.com - with monthly updates from the Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery, plus videos of procedures, an image library, review questions, and more.Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more.View clinical and physical findings and operative techniques more vividly with a new full-color layout and more full-color images.

Dans les sociétés occidentales, les varices et les télangiectasies sont l'une des principales manifestations de la maladie veineuse chronique qui touche près d'un individu sur deux. Motif fréquent de consultation, cette maladie augmente avec l'âge et atteint l'homme presque autant que la femme. Sa forte prévalence, les souffrances qu'elle engendre et les complications qu'elle peut entraîner (invalidité, mortalité) imposent un diagnostic précis et une prise en charge efficace par le praticien. Afin d'aider le médecin dans son exercice quotidien, cette nouvelle édition, entièrement réactualisée et agrémentée d'illustrations en couleur, rappelle avec précision l'aspect, les symptômes et les complications liées aux varices et télangiectasies. Elle fait le point sur les examens cliniques et complémentaires, les techniques d'imagerie à disposition du praticien et consacre une large place à la prévention ainsi qu'à la thérapeutique médicamenteuse et chirurgicale. Fort d'une équipe plurisdisciplinaire référente dans le domaine, cet ouvrage est indispensable à tout praticien confronté au diagnostic et au traitement des maladies veineuses.La référence pour un diagnostic précis et une prise en charge efficace. - L'aspect, les symptômes et les complications liées aux varices et télangiectasies. - Le point sur les examens cliniques et complémentaires et les techniques d'imagerie disponibles pour le praticien. - La prévention, la thérapeutique médicamenteuse et chirurgicale.

Optimale Praxisrelevanz: Evidenz-basierte Empfehlungen zur empirischen Initialtherapie mit Antibiotika, gezielte Therapie nach erfolgter Erregerdiagnose, Berücksichtigung der aktuellen Resistenzsituation Optimale Effizienz: Unter Berücksichtigung u.a. von Wirkungsspektrum, Pharmakokinetik, Eradikatonsrate, Therapiedauer, Nebenwirkungen Optimale Patientenorientierung: Unter Berücksichtigung u.a. von Compliance, Begleiterkrankungen/Alter, Ausprägung der Erkrankung, lokalen/epidemiologischen Bedingungen Zusatzinfos: Zulassungen und Bewertung der Antibiotika, Klinik, Differentialdiagnosen, Diagnostik, Klassifikationen von Erkrankungen