151. Superspreading events in the transmission dynamics of SARS-CoV-2: Opportunities for interventions and control
- Author
-
Antoine Allard, Hao Hu, Benjamin M. Althouse, Edward Allen Wenger, Laurent Hébert-Dufresne, Samuel V. Scarpino, and Joel C. Miller
- Subjects
RNA viruses ,0301 basic medicine ,Viral Diseases ,Pulmonology ,Coronaviruses ,Epidemiology ,Psychological intervention ,Disease ,Disease Outbreaks ,law.invention ,Medical Conditions ,0302 clinical medicine ,law ,Pandemic ,Medicine and Health Sciences ,Poisson Distribution ,030212 general & internal medicine ,Biology (General) ,Pathology and laboratory medicine ,Virus Testing ,Coinfection ,General Neuroscience ,Medical microbiology ,Viral Load ,Infectious Diseases ,Transmission (mechanics) ,Viruses ,SARS CoV 2 ,Pathogens ,General Agricultural and Biological Sciences ,SARS coronavirus ,Coronavirus disease 2019 (COVID-19) ,Essay ,QH301-705.5 ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Opportunistic Infections ,Biology ,Microbiology ,General Biochemistry, Genetics and Molecular Biology ,Respiratory Disorders ,03 medical and health sciences ,Diagnostic Medicine ,Virology ,Environmental health ,Humans ,Stochastic Processes ,Biology and life sciences ,General Immunology and Microbiology ,SARS-CoV-2 ,Organisms ,Viral pathogens ,COVID-19 ,Outbreak ,Covid 19 ,Microbial pathogens ,030104 developmental biology ,Medical Risk Factors ,Respiratory Infections ,Basic reproduction number ,Viral Transmission and Infection - Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus Disease 2019 (COVID-19) disease, has moved rapidly around the globe, infecting millions and killing hundreds of thousands. The basic reproduction number, which has been widely used—appropriately and less appropriately—to characterize the transmissibility of the virus, hides the fact that transmission is stochastic, often dominated by a small number of individuals, and heavily influenced by superspreading events (SSEs). The distinct transmission features of SARS-CoV-2, e.g., high stochasticity under low prevalence (as compared to other pathogens, such as influenza), and the central role played by SSEs on transmission dynamics cannot be overlooked. Many explosive SSEs have occurred in indoor settings, stoking the pandemic and shaping its spread, such as long-term care facilities, prisons, meat-packing plants, produce processing facilities, fish factories, cruise ships, family gatherings, parties, and nightclubs. These SSEs demonstrate the urgent need to understand routes of transmission, while posing an opportunity to effectively contain outbreaks with targeted interventions to eliminate SSEs. Here, we describe the different types of SSEs, how they influence transmission, empirical evidence for their role in the COVID-19 pandemic, and give recommendations for control of SARS-CoV-2., This Essay discusses how the transmission of COVID-19 is dominated by superspreading events, proposing that finding ways to cut the long tail of secondary infections is important for controlling onward transmission.
- Published
- 2020