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158. Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer.

Author

Thöm I, Andritzky B, Schuch G, Burkholder I, Edler L, Johansen JS, Bokemeyer C, Schumacher U, Laack E, Thöm, Ina, Andritzky, Birte, Schuch, Gunter, Burkholder, Iris, Edler, Lutz, Johansen, Julia S, Bokemeyer, Carsten, Schumacher, Udo, and Laack, Eckart

Subjects
GLYCOPROTEINS, LUNG cancer, METASTASIS, PROGNOSIS, PROTEINS, TUMOR markers
Abstract

Background: The glycoprotein YKL-40 is synthesized both by cancer cells and by tumor-associated macrophages and plays a functional role in tumor progression. Consequently, high serum YKL-40 levels have been associated with a poor prognosis in patients with several cancer types. However, the role of YKL-40 has not been established in nonsmall cell lung cancer (NSCLC). Methods: Pretreatment serum levels of YKL-40 were determined in 189 patients with NSCLC (143 men and 46 women; median age, 62 years;, age range, 41-76 years). Twelve percent of patients had stage IIIB disease, and 88% had stage IV disease. Ninety-eight patients received combined gemcitabine and vinorelbine, and 91 received combined gemcitabine, vinorelbine, and cisplatin as first-line chemotherapy. The median overall survival was 37 weeks. Results: Patients had a median serum YKL-40 level of 209 ng/mL (range, 19-2153 ng/mL). No correlation was observed between overall survival and the type of chemotherapy regimen used, tumor stage, sex, or histologic types. Patients with high serum YKL-40 levels (greater than the median level for all patients [209 ng/mL]) had a significantly shorter survival than patients with serum YKL-40 levels below the median (median survival, 32 weeks vs 41 weeks; P = .007). In multivariate analysis, the serum YKL-40 level, the presence of bone lesions, and the serum lactate dehydrogenase level were independent, statistically significant prognostic factors. Conclusions: The pretreatment serum YKL-40 level was identified as a new, independent prognostic biomarker in patients with metastatic NSCLC and may help to determine the individual prognosis of these patients. [ABSTRACT FROM AUTHOR]

Published
2010
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160. Oral Administration of Idarubicin as First Line Cytostatic Therapy in Patients with Metastasized Breast Cancer and Favourable Prognosis

Author

Possinger, K., primary, Wagner, H., additional, Worst, P., additional, Queißer, W., additional, Bremer, K., additional, Rieche, K., additional, Klee, M., additional, Westerhausen, M., additional, Donhuijsen-Ant, R., additional, Fritze, D., additional, Edler, L., additional, Stiegelbauer, G., additional, and Burk, K., additional

Published
1991
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161. Standard Operating Procedures for Clinical Trials of the CESAR Central European Society for Anticancer Drug Research - EWIV : Supplement Issue: Onkologie 2003, Vol. 26, Suppl. 6

Author

Gastl, G., Berdel, W.E, Edler, L., Jaehde, U., Port, R., Mross, K., Scheulen, M., Sindermann, H., Dittrich, C., Gastl, G., Berdel, W.E, Edler, L., Jaehde, U., Port, R., Mross, K., Scheulen, M., Sindermann, H., and Dittrich, C.

Subjects
Clinical trials, Antineoplastic agents--Development
Abstract

'October 2003.'

Published
2003

166. Diabetes mellitus und Mammakarzinom

Author

Unterburger, P., primary, Sinop, A., additional, Noder, W., additional, Berger, M.R., additional, Fink, M., additional, Edler, L., additional, Schmähl, D., additional, and Ehrhart, H., additional

Published
1990
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169. Chemotherapie gastrointestinaler Tumoren

Author

Queißer, W., primary, Klein, H.O., additional, Heim, M.E., additional, Herrmann, R., additional, Hossfeld, D.K., additional, Obrecht, J.P., additional, Preusser, P., additional, Schmoll, H. J., additional, Steinke, B., additional, Weh, H. J., additional, Wilke, H., additional, and Edler, L., additional

Published
1990
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172. DNA of adeno-associated virus (AAV) in testicular tissue and in abnormal semen samples.

Author

Erles, Kerstin, Rohde, Volker, Thaele, Michael, Roth, Susanne, Edler, Lutz, Schlehofer, Jörg R., Erles, K, Rohde, V, Thaele, M, Roth, S, Edler, L, and Schlehofer, J R

Abstract

Background: Human genital tissues, including spermatozoa, have been found to be frequently infected with the helper-virus dependent parvovirus, adeno-associated virus (AAV).Methods: To assess the role of AAV infection in disorders of the male reproductive system, semen samples from 95 men (including 73 men attending a fertility programme) and testicular samples from patients with azoospermia (n = 38) or prostate cancer (n = 8) were analysed using polymerase chain reaction for the presence of AAV DNA. Semen quality was assessed according to World Health Organization guidelines and the grade of atrophy of testicular biopsies was determined histomorphologically.Results: AAV DNA was detected in 38% (28/73) of ejaculates from men with abnormal semen analyses (oligoasthenozoospermia or asthenozoospermia) and in 4.6% of normal semen samples (1/22, P = 0.003). DNA from AAV helper-viruses (human papillomaviruses, cytomegalovirus) was detected at similar frequencies in normal and abnormal semen samples. In testes, AAV DNA was detected in 10 out of 38 biopsies from infertile men (26%), and in 2 out of 8 orchidectomy samples.Conclusion: The data show an increased incidence of AAV infection with abnormal semen analysis. Detection of AAV DNA in the testes might point to a role for AAV infection in male infertility, possibly by interfering with spermatozoa development. [ABSTRACT FROM AUTHOR]

Published
2001
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174. Analysis of the inhibition of N-nitroso-dimethylamine activation in the liver by N-nitro-dimethylamine using a new non-linear statistical method.

Author

Frei, E, Gilberg, F, Schröder, M, Breuer, A, Edler, L, and Wiessler, M

Abstract

N-nitro-dimethylamine (NTDMA) is carcinogenic to rats: it induces nasal cavity tumours. It can be demethylated to N-nitromethylamine and formaldehyde and reduced to N-nitroso-dimethylamine (NDMA): a potent liver carcinogen and also of the nasal cavity if activation in the liver is blocked. To explain the mechanism of NTDMA carcinogenicity we compared its demethylation with that of NDMA in liver microsomes from female and male rats, untreated, fasted or treated with ethanol to induce cytochrome P450 2E1 (CYP2E1). Kinetic parameters were analysed by non-linear statistical methods, which yielded unbiased parameters estimates for the calculated Km and Vmax values. Km for both compounds was very similar in females (24-47 μM) whereas Vmax for NTDMA was consistently higher than for NDMA as substrate: 1.07-4.70 nmol formaldehyde/mg microsomal protein x min and 0.52-2.76 nmol, respectively. In liver microsomes from induced male rats NTDMA was found to be a much more effective inhibitor of NDMA activation (KEI 39.6-73.6 μM) than NDMA of NTDMA demethylation (KEI 224-286 μM). Nasal microsomes can demethylate both NDMA and NTDMA but the kinetics are vastly different. NTDMA is demethylated at a linear rate and 10-fold more effectively than NDMA. The mechanism of carcinogenicity of ingested NTDMA, we propose, is a partial reduction to NDMA in the liver by residual NTDMA, which enables NDMA to reach the nasal mucosa where it is activated to DNA-aklylating species and the observed tumours are formed. [ABSTRACT FROM PUBLISHER]

Published
1999
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181. Combination chemotherapy (VAC/FMC) with immunostimulation in metastatic breast cancer: A randomized study comparing different times and routes of administration of corynebacterium parvum.

Author

Fritze, D., Massner, B., Becher, R., Kaufmann, M., Illiger, H., Hartlapp, J., Queißer, W., Abel, U., Edler, L., Mayr, A., Drings, P., Westerhausen, M., Jungi, W., and Senn, H.

Abstract

From January 1978 to December 1980, 222 patients with metastatic breast cancer were included into a prospective multicenter trial. All patients were treated once a month with six cycles of VAC- (vincristine, adriamycin, cyclophosphamide) chemotherapy, followed by FMC (5-fluor-ouracil, methotrexate, cyclophosphamide) until progression was documented. By random assignment, the patients received immunostimulation with Corynebacterium parvum (CP) by one of four methods: subcutaneous (SC) on either day 1 or day 14, intravenous (IV) on either day 1 or day 14. The 214 evaluable patients were equally distributed to the four arms. The rates of complete or partial response to VAC/FMC plus CP did not differ significantly between the treatment groups. Of our patients, 22-33% were definite treatment failures. The Kaplan-Meier curves of duration of remission (medians 14 vs. 9 vs. 13 vs. 11 months) did not differ significantly. Only small differences in survival were noted among the four study groups (medians 15.4 vs. 17.5 vs. 17.2 vs. 13.0 months). However, complete and partial responders lived significantly longer (Log rank test P=0.008), when CP was given on day 14 by the SC rather than IV route (29+ vs. 14.3 months). Patients in the four study groups were treated with virtually identical doses of VAC/FMC chemotherapy. Patients receiving CP intravenously on day 14 experienced significantly lower mean leukocyte counts than patients in the other groups. Many patients suffered from high temperature (requiring treatment with antipyretics) and severe gastrointestinal toxicity, particularly when CP was given IV on day 1 together with the chemotherapy. Sixteen patients developed skin ulcers following repeated SC injections of CP. They showed a 4-month longer median survival than patients without these local reactions. Taken together, the results suggest that adding CP in the ways tested to monthly VAC/FMC chemotherapy is of no benefit to patients with metastatic breast cancer. [ABSTRACT FROM AUTHOR]

Published
1984
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182. A randomized study of combination chemotherapy (VAC-FMC) with or without immunostimulation by corynebacterium parvum in metastatic breast cancer.

Author

Fritze, D., Becher, R., Massner, B., Kaufmann, M., Bruntsch, U., Gallmeier, W., Mayr, A., Drings, P., Abel, U., Edler, L., Jungi, W., Queißer, W., and Senn, H.

Abstract

Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1982
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183. Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine.

Author

Kinscherf, R., Hack, V., Fischbach, T., Friedmann, B., Weiss, C., Edler, L., Bärtsch, P., and Dröge, W.

Abstract

Skeletal muscle catabolism, low plasma glutamine, and high venous glutamate levels are common among patients with cancer or human immunodeficiency virus infection. In addition, a high glycolytic activity is commonly found in muscle tissue of cachectic cancer patients, suggesting insufficient mitochondrial energy metabolism. We therefore investigated (a) whether an 'anaerobic physical exercise' program causes similar changes in plasma amino acid levels, and (b) whether low plasma glutamine or high glutamate levels are risk factors for loss of body cell mass (BCM) in healthy human subjects, i.e., in the absence of a tumor or virus infection. Longitudinal measurements from healthy subjects over longer periods suggest that the age-related loss of BCM occur mainly during episodes with high venous glutamate levels, indicative of decreased muscular transport activity for glutamate. A significant increase in venous glutamate levels from 25 to about 40 μM was seen after a program of 'anaerobic physical exercise.' This was associated with changes in T lymphocyte numbers. Under these conditions persons with low baseline levels of plasma glutamine, arginine, and cystine levels also showed a loss of BCM. This loss of BCM was correlated not only with the amino acid levels at baseline examination, but also with an increase in plasma glutamine, arginine, and cystine levels during the observation period, suggesting that a loss of BCM in healthy individuals terminates itself by adjusting these amino acids to higher levels that stabilize BCM. To test a possible regulatory role of cysteine in this context we determined the effect of N-acetyl-cysteine on BCM in a group of subjects with relatively low glutamine levels. The placebo group of this study showed a loss of BCM and an increase in body fat, suggesting that body protein had been converted into other forms of chemical energy. The decrease in mean BCM/body fat ratios was prevented by N-acetyl-cysteine, indicating that cysteine indeed plays a regulatory role in the physiological control of BCM. [ABSTRACT FROM AUTHOR]

Published
1996
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184. Treatment of autochthonous rat colonic adenocarcinomas with a thioether-lysophospholipid derivative in mono-and combinationchemotherapy.

Author

Heim, M., Swoboda, M., Pahlke, W., Edler, L., and Bicker, U.

Abstract

In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thiother-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no difference in the survival time of treated and untreated animals. The median large-bowel tumor weight was significantly lower in the TLP/5-FU and TLP/5-FU/BCNU combination therapy groups than in the control groups. Transient hepatotoxicity was observed in the high-dosage (50 mg/kg body weight twice weekly) TLP group. This study confirmed the relative resistance of AMMN-induced colorectal carcinomas to antineoplastic treatment. [ABSTRACT FROM AUTHOR]

Published
1984
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185. DNA analysis, chemoresistance testing and hormone receptor levels as prognostic factors in advanced ovarian carcinoma.

Author

Schneider, J., Edler, L., Kleine, W., and Volm, M.

Abstract

Fifty patients with advanced (stage III or IV) ovarian carcinoma were followed-up until the date of their death or their fifth year of survival. Prognostic factors, including those currently in use, as well as ploidy and proliferation, chemoresistance testing and hormone receptor levels of the tumours were analysed for predictive value and independence from each other. In the univariate analysis, only stage, residual tumour, second-look status, chemoresistance, ploidy and proliferation were significantly correlated with survival. After being tested in a multivariate Cox regression model, however, only the results of chemoresistance testing at initiation of therapy, and second-look status at a later point, retained prognostic significance. Within the group of patients with a positive second-look, i.e., with the worst prognosis, the chemoresistance test was still able to discriminate between two subgroups with significantly different survival. [ABSTRACT FROM AUTHOR]

Published
1990
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186. Dose-response analysis of the enhancement of liver tumour formation in CF-1 mice by dieldrin.

Author

Tennekes, H.A., Edler, L., and Kunz, H.W.

Abstract

The current study was undertaken to investigate the dose-response characteristics of dieldrin-mediated enhancement of liver tumour formation in CF-1 mice. The median time to tumour development was established in controls, and in dieldrin-treated animals at six levels of continuous exposure (0.1, 1, 2.5, 5, 10 and 20 p.p.m.). The results of the analysis, which was based on liver tumour data from two parallel chronic feeding studies involving 1800 mice, are at variance with those reported by Druckrey for various established chemical carcinogens. In a double-logarithmic system of coordinates there was no linear relationship between the median total dose or the median time to tumour formation and the daily dieldrin exposure level. These results suggest that the tumourigenicity of this compound in CF-1 mouse liver is determined not by the sum of all consecutive doses, but rather by the level of daily exposure, and, presumably, the duration of treatment. This concept is consistent with the observed dose-dependency and reversible nature of dieldrin-induced subcellular changes in mouse liver. These considerations, together with evidence that dieldrin and its mammalian metabolites possess neither genotoxic activity nor potential, are not inconsistent with the concept that this compound is devoid of initiating potential, and operates by enhancing the effect of a genetically linked oncogenic factor in CF-1 mouse liver. [ABSTRACT FROM PUBLISHER]

Published
1982

187. Oceanographic variability in the Skagerrak and Northern Kattegat, May–June, 1990.

Author

Danielssen, D. S., Edler, L., Fonselius, S., Hernroth, L., Ostrowski, M., Svendsen, E., and Talpsepp, L.

Subjects
FISHERIES, OCEAN circulation, COASTS, CHLOROPHYLL
Abstract

The Skagerrak Experiment (SKAGEX), was a large, international, ICES-supported joint venture, carried out in the Skagerrak–Kattegat area on four different surveys in the period 1990–1991. It involved some 20 institutes and, at times, up to 17 research vessels. The main aim of the Experiment was to identify and quantify the different water masses entering and leaving the Skagerrak area and their variation over time. It also aimed to investigate the mechanisms that drive the circulation and to study their effects on biological processes. The aim was to be attained mostly through extensive synoptic observations. This paper focuses on the variability in physical, chemical and biological parameters during the first part of SKAGEX, 24 May–20 June 1990. During the first half of the period of investigation, the main outflow from the Skagerrak, represented by the Norwegian Coastal Current, was barotropic with daily mean velocities varying from 10–40 cm s−1. During the second half a clear baroclinic current component developed, giving rise to near surface velocities of up to 100 cm s−1. A pronounced feature in the Skagerrak during the study was the counter-clockwise circulation of the Norwegian Coastal Current at times of strong northwesterly winds. During such conditions this surface water reached as far as the Danish coast south of 57°N and upwelling along the Norwegian coast was also found. During northerly winds upwelling also occurred along the Swedish coast. The nutrient-rich Jutland Coastal Water, originating from the German Bight, was never found to reach the inner part of the Skagerrak during this first part of SKAGEX. It was partly blocked or diluted by other water-masses. A large “ridge” of nutrient-rich Atlantic water was found in the central Skagerrak throughout the investigation. It is shown that this elongated “ridge” was associated with the deepest (>500 m) area of the Skagerrak. Within this area, high subsurface chlorophyll concentrations were always found and, due to the persistence of the supply of nutrients, it is concluded that this phenomenon could be one of the main reasons for the high productivity of the Skagerrak. [ABSTRACT FROM PUBLISHER]

Published
1997
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188. Simple elementary method for the quantification of focal liver lesions induced by carcinogens.

Author

Enzmann, H., Edler, L., and Bannasch, P.

Abstract

Quantification of focally arranged preneoplastic cell populations in the liver is relevant for numerous experiments. An easy-to-process elementary method is presented for the estimation of the number of foci per cm and the size distribution of the foci on the basis of classifying areas of the profiles on the histological section. Using geometrically decreasing size classes, we have obtained the formula: where is the number of foci per unit of volume of the size class , is the number of profiles of the class K per surface unit and A and B are constants dependent on the selection of the boundaries of the size classes. The method presented provides results that are at least as accurate as the values for the numbers of foci per cm arrived at by other methods used so far, whereas the distribution of the focus volumes describes the real situation better. It is relatively easy to process the data collected from the section and this can also be done without specific programs developed for this purpose. The method is especially recommended for investigators who only occasionally deal with morphometric questions and are therefore not interested in more complicated methods. [ABSTRACT FROM PUBLISHER]

Published
1987

189. Ligand/Receptor Binding for 2,3,7,8-TCDD: Implications for Risk Assessment.

Author

PORTIER, C., TRITSCHER, A., KOHN, M., SEWALL, C., CLARK, G., EDLER, L., HOEL, D., and LUCIER, G.

Abstract

There is renewed controversy regarding safe exposure levels for dioxin. At the heart of this controversy is the hypothesis that toxic effects of dioxin are receptor-mediated and therefore a “threshold” should exist below which no toxic effects can occur. Our research focuses on the ability of dioxin to alter protein levels in rodent livers. Established effects of exposure to dioxin are the induction of cytochrome P450-1A1 and P450-1A2 and a reduction in the maximal binding of the epidermal growth factor receptor in rat livers. An initiation-promotion protocol was used to study the effects of dioxin in female Sprague-Dawley rats. Animals were administered a single initiating dose of diethylnitrosamine followed by 16 biweekly gavage doses of 2,3,7,8-TCDD. Steady-state pharmacodynamic models were fit to these data assuming a combination of Hill kinetics and Michaelis-Menten kinetics. Two classes of models were developed which postulate two different mechanisms for the constitutive expression and TCDD-induced alterations in the levels of these proteins. The results are consistent with models which follow proportionate response in the low-dose region (no threshold) and with models which allow for a low-dose threshold. In all cases studied, the best fitting model exhibited no “threshold” for the effects of TCDD on the modulation of these proteins. The finding is consistent with the knowledge that for some receptor-mediated responses, there is a proportional relationship between receptor occupancy and biological response, even at low ligand concentrations. The results presented here illustrate that a threshold for the biological effects of TCDD exposure cannot be assumed simply on the basis that dioxin response is receptor-mediated. [ABSTRACT FROM PUBLISHER]

Published
1993

190. Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG

Author

Schadendorf, D., Ugurel, S., Schuler-Thurner, B., Nestle, F.O., Enk, A., Bröcker, E.-B., Grabbe, S., Rittgen, W., Edler, L., Sucker, A., Zimpfer-Rechner, C., Berger, T., Kamarashev, J., Burg, G., Jonuleit, H., Tüttenberg, A., Becker, J.C., Keikavoussi, P., Kämpgen, E., and Schuler, G.

Abstract

Background:This randomized phase III trial was designed to demonstrate the superiority of autologous peptide-loaded dendritic cell (DC) vaccination over standard dacarbazine (DTIC) chemotherapy in stage IV melanoma patients.

Published
2006
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194. Fraud in Medical Research

Author

Ranstam, J., Buyse, M., George, S. L., Evans, S., Geller, N. L., Scherrer, B., Lesaffre, E., Murray, G., Edler, L., and Hutton, J. L.

Published
2000
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197. Strict supercritical generation-dependent Crump–Mode–Jagers branching processes

Author

Edler, L.

Abstract

The general age-dependent branching model of Crump, Mode and Jagers will be generalized towards generation-dependent varying lifespan and reproduction distributions. A system of integral and renewal equations is established for the generating functions and the first two moments of Zi(t) (the number of individuals alive at time t), if the population was initiated at time 0 by one ancestor of age 0 from generation i.Convergence in quadratic mean of Zi(t)/EZi(t) as ttends to infinity is obtained if the generation-dependent reproduction functions converge to a supercritical one. In particular, if this convergence is slow enough t?exp (at) is the asymptotic behavior of EZi(t) for ttending to infinity, where ? is a positive real number and a the Malthusian parameter of growth of the limiting reproduction function.

Published
1978
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198. Abstract

Author

Mache, Ch., Urban, Ch., Sauer, H., Brandesky, G., Meßner, H., Grienberger, H., Becker, H., Slave, I., Hauer, Ch., Pakisch, B., Oberbauer, R., Mokry, M., Ebner, F., Kleinert, R., Schiller, D., Kasparu, H., Schneider, G., Sega, W., Lutz, D., Mader, R. M., Steger, G. G., Sieder, A. E., Ovissi, L., Roth, E., Hamilton, G., Jakesz, R., Rainer, H., Schenk, T., Kornek, G., Schulz, F., Depisch, D., Rosen, H., Sebesta, Ch., Scheithauer, W., Locker, G. J., Czernin, J., Derfler, K., Gnant, M., Schiessel, R., Petru, E., Pickel, H., Heydarfadai, M., Lahousen, M., Haas, J., Sagaster, P., Flamm, J., Umek, H., Essl, R., Teich, G., Micksche, M., Ludwig, H., Ambros, P. F., Lestou, V., Strehl, S., Mann, G., Gadner, H., Eibl, B., Greiter, E., Grünewald, K., Gastl, G., Thaler, J., Aulitzky, W., Lion, T., Henn, T., Gaiger, A., Hofmann, J., Wolf, A., Spitaler, M., Ludescher, Christof, Grunicke, H., Mitterbauer, G., Stangl, E., Geissler, K., Jäger, U., Lechner, K., Mannhalter, C., Haas, Oskar A., Tirita, Anthi, Kahls, P., Haas, O., Hinterberger, W., Linkesch, W., Pober, Michael, Fae, Ingrid, Kyrle, Alexander, Neumeister, Andrea, Panzer, Simon, Kandioler, D., End, A., Grill, R., Karlic, H., Inhauser, T., Chott, A., Pirc-Danoewinata, H., Klepetko, W., Heinz, R., Hopfinger-Limberger, G., Koller, E., Schneider, B., Pittermann, E., Lorber, C., Eichinger, S., Neumann, E., Weidinger, J., Gisslinger, H., Bedford, P., Jones, D., Cawley, J., Catovsky, D., Bevan, P., Scherrer, R., Bettelheim, P., Knöbl, P., Kyrie, P. A., Lazcika, K., Schwarzinger, I., Sillaber, C., Watzke, H., Dávid, M., Losonczy, H., Matolcsy, A., Papp, M., Prischl, F. C., Schwarzmeier, J. D., Zoubek, Andreas, Harbott, Jochen, Ritterbach, Jutta, Ritter, Jörg, Sillaber, Ch., Agis, H., Spanblöchl, E., Sperr, W. R., Valent, P., Czerwenka, K., Virgolini, I., Li, S. R., Müller, M., Wrann, M., Gaggl, S., Fasching, B., Herold, M., Geissler, D., Nachbaur, D., Huber, Ch., Schwaighofer, H., Pichl, M., Niederwieser, D., Gilly, B., Weissel, H., Lorber, Ch., Schwarzmeier, J., Gasché, C., Reinisch, W., Hilgarth, M., Keil, F., Thomssen, C., Kolb, H. J., Holler, E., Wilmanns, W., Tilg, H., Gächter, A., Panzer-Grümayer, E. R., Majdic, O., Kersey, J. H., Petzer, A. L., Bilgeri, R., Zilian, U., Geisen, F. H., Haun, M., Konwalinka, G., Fuchs, D., Zangerle, R., Artner-Dworzak, E., Weiss, G., Fritsch, P., Tilz, G. P., Dierich, M. P., Wachter, H., Schüller, J., Czejka, M. J., Jäger, W., Meyer, B., Weiss, C., Schernthaner, G., Marosi, Ch., Onderka, E., Schlögl, B., Maca, T., Hanak, R., Mannhalter, Ch., Brenner, B., Mayer, R., Langmann, A., Langmann, G., Slave, J., Poier, E., Stücklschweiger, G., Hackl, A., Fritz, A., Pabinger, I., Willfort, A., Groiss, E., Bernhart, M., Waldner, R., Krieger, O., Nowotny, H., Strobl, H., Michlmayr, G., Mistrik, M., lstvan, L., Kapiotis, S., Laczika, K., Speiser, W., Granena, A., Hermans, J., Zwaan, F., Gratwohl, A., Labar, B., Mrsić, M., Nemet, D., Bogdanić, V., Radman, I., Zupančić-Šalek, Silva, Kovačević-Metelko, Jasna, Aurer, I., Forstinger, C., Scholten, C., Kier, P., Kalhs, P., Schwinger, W., Slavc, I., Lackner, H., Nussbaumer, W., Fritsch, E., Fink, M., Zechner, O., Kührer, I., Kletter, V., Frey, S., Leitgeb, C., Fritz, E., Silly, H., Brezinschek, R., Kuss, I., Stöger, H., Schmid, M., Samonigg, H., Wilders-Truschnig, M., Schmidt, F., Bauernhofer, T., Kasparek, A. K., Ploner, F., Stoeger, H., Moser, R., Leikauf, W., Klemm, F., Pfeffel, F., Niessner, H., Poschauko, H., Pojer, E., Locker, G. J., Braun, J., Gnant, M. F. X., Michl, I., Pirker, R., Liebhard, A., Zielinski, C., Dittrich, C., Bernát, S. I., Pongrácz, E., Kastner, J., Raderer, M., Jorbenyi, Z., Yilmaz, A., Suardet, L., Lahm, H., Odartchenko, N., Varga, Gy., Sréter, L. A., Oberberg, D., Berdel, W. E., Budiman, R., Brand, C., Berkessy, S., Radványi, G., Pauker, Zs., Nagy, Zs., Karádi, Å., Serti, S., Hainz, R., Kirchweger, P., Prager, C., Prada, J., Neifer, S., Bienzle, U., Kremsner, P., Kämmerer, B., Vetterlein, M., Pohl, W., Letnansky, K., Imre, S. 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Published
1992
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199. Tumor induction and prophylaxis following different forms of intestinal urinary diversion in a rat model

Author

Kälble, T., Busse, K., Amelung, F., Waldherr, R., Berger, M. R., Edler, L., and Riedmiller, H.

Abstract

Eighty Wistar rats were randomized into two groups. In group 1 vesicosigmoidostomy with proximal colostomy was performed, in group 2, vesicosigmoidostomy. The total tumor incidence did not differ significantly (group 1 10/40, 25%; group 2 13/40, 32.5%). The tumor spectrum differed, with more adenocarcinomas in group 2 (11/40, 27.5% vs 4/40, 10%;P=0.047) and urothelial carcinomas only in group 1 (5/40, 2.5%). One hundred and ten other Wistar rats were randomized into three groups. Animals in group A received vesicoileosigmoidostomy, group B, two-step vesicosigmoidostomy with initial separation of urine and the urocolonic anastomosis, group C, vesicosigmoidostomy. Significantly fewer adenocarcinomas were observed in group A (2/40, 5%) than in group B (16/40, 40%,P<0.002) and group C (9/30, 30%;P<0.007). These results indicate a similar cancer risk in all continent forms of urinary diversion, at least via colon. Ileal interposition seems to be an effective carcinoma prophylaxis following ureterosigmoidostomy. The proliferative instability at the urointestinal anastomosis is crucial for the pathogenesis and prophylaxis of this form of carcinogenesis, whereas urine seems to play only a minor role.

Published
1995
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