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Hemostasis Management of the Pediatric Surgical Patient provides knowledge on the emerging area of pediatric hemostasis and its management. It discusses aspects of perioperative blood management in the pediatric population, including how to accurately estimate and monitor bleeding and determine optimal treatment regimens for bleeding in pediatric surgical patients. It also provides information on the implementation of intraoperative blood conservation strategies, goal-directed transfusion therapy, and postoperative estimation of bleeding and thrombotic risks. This book is a valuable resource to pediatric practitioners and researchers who need comprehensive information on pediatric hematology, from basic physiology to pre-, intra- and postoperative care of pediatric patients. The coagulation system of children evolves with age as evidenced by marked physiological differences in the concentration of hemostatic proteins between children of different age groups and adults. Consequently, there are distinct differences in hemostatic management between adult and pediatric patients. - Covers essential concepts in hemostasis, indicating instances where pediatric and adult data conflict, along with foundational information on disorders of hemostasis in children and blood bank management for pediatric patients - Concisely covers specifics of perioperative hemostatic management in neonates and children, including bedside monitoring of coagulation and goal-directed treatment of coagulopathy - Discusses hemostatic management in the entire perioperative period, from preoperative assessment until discharge from the hospital

The World Health Organization defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”, and its constitution also asserts that health for all people is “dependent on the fullest co-operation of individuals and States”. The ongoing pandemic has highlighted the power of both healthy and unhealthy information, so while healthcare and public health services have depended upon timely and accurate data and continually updated knowledge, social media has shown how unhealthy misinformation can be spread and amplified, reinforcing existing prejudices, conspiracy theories and political biases. This book presents the proceedings of MedInfo 2021, the 18th World Congress of Medical and Health Informatics, held as a virtual event from 2-4 October 2021, with pre-recorded presentations for all accepted submissions. The theme of the conference was One World, One Health – Global Partnership for Digital Innovation and submissions were requested under 5 themes: information and knowledge management; quality, safety and outcomes; health data science; human, organizational and social aspects; and global health informatics. The Programme Committee received 352 submissions from 41 countries across all IMIA regions, and 147 full papers, 60 student papers and 79 posters were accepted for presentation after review and are included in these proceedings. Providing an overview of current work in the field over a wide range of disciplines, the book will be of interest to all those whose work involves some aspect of medical or health informatics.

This book provides an inclusive and comprehensive discussion of the transmission, science, biology, genome sequencing, diagnostics, and therapeutics of COVID-19. It also discusses public and government health measures and the roles of media as well as the impact of society on the ongoing efforts to combat the global pandemic. It addresses almost every topic that has been studied so far in the research on SARS-CoV-2 to gain insights into the fundamentals of the disease and mitigation strategies. This volume is a useful resource for virologists, epidemiologists, biologists, medical professionals, public health and government professionals, and all global citizens who have endured and battled against the pandemic.

This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource forpracticing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.

Explore this concise and clinically focused approach to the field of blood banking and transfusion therapy The Fifth Edition of Transfusion Medicine delivers a succinct, thorough, clinically focused, practical and authoritative treatment of a full range of topics in transfusion therapy. This ranges from issues with the blood supply, recruitment of both whole blood and apheresis donors, blood collection and storage, blood testing, blood safety, and transmissible diseases. This edition has been fully updated and revised to include exciting cellular therapies for cancer, transplantation of both hematopoietic cells and solid organs, infectious diseases and regenerative medicine. The Fifth Edition includes new authors with highly relevant content that provides a solid grounding for readers in the field. The book: Is an approachable comprehensive guide to the field of blood banking and transfusion medicine Provides complete and timely perspective on crucial topics, including the HLA system in transfusion medicine and transplantation and quality programs in blood banking and transfusion medicine Is extensively referenced, making it simple for readers to conduct further research on the topics of interest to them Includes new chapters on pediatric transfusion medicine and pathogen reduction Has an expended chapter on patient blood management Provides extensive discussions of the clinical use of blood transfusion in a wide variety of clinical situations including recent development In the management of acute traumatic blood loss Provides updated information about blood groups and molecular testing making inroads into clinical practice along with discussions of laboratory detection of blood groups and provision of red cells Perfect for all those working in the field of blood banking, transfusion medicine and hematology or oncology and fellows in pathology, hematology, surgery and anesthesiology. Transfusion Medicine is a good introduction for technologists specializing in blood banking and non-medical personnel working in areas related to hematology and transfusion medicine. Transfusion Medicine will also earn a place in the libraries of practicing pathologists with responsibility for blood banks.

Join the generations of students who have embarked on successful careers with a firm foundation in the theory and practice of blood banking and transfusion practices. Denise Harmening's classic text teaches you not only how to perform must-know tests and tasks, but to understand the scientific principles behind them. You'll begin with a review of the basic concepts of red blood cell and platelet preservation, genetics, immunology, and molecular biology. Then you'll move to the hows and whys of clinical practice. And, you'll be prepared for new advances in the field.

Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors. - Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing - Includes new case studies that highlight clinical relevance and errors to avoid - Highlights the best titles published within a variety of medical specialties - Reviewed by medical librarians and content specialists, with key selections compiled in their annual list

Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. - Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. - Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. - Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. - Consolidates today's available information on this timely topic into a single, convenient resource.

This book presents detailed state of the art knowledge on the humoral primary immunodeficiencies (PIDs), i.e., disorders arising from impaired antibody production due to defects intrinsic to B cells or defective interaction between B and T cells. There is extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the B cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel humoral PID genes and related clinical applications, mucosal B cells, and the various clinical phenotypes of humoral PIDs. Aspects such as differential diagnosis, clinical management in children and adults, and the role of vaccines are also addressed. The authors are all recognized experts from Europe, Australia, and the United States. Humoral Primary Immunodeficiencies will be of high value for immunologists, pediatricians,rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD and PhD students.

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. This extensive title, which combines scientific principles with up-to-date clinical procedures, has been thoroughly updated for the fourteenth edition. You'll find in-depth material on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them.

Offering a concise overview of transfusion medicine, including best practices for specific clinical settings, this practical resource by Dr. Robert W. Maitta covers the key information you need to know. Holistic, multidisciplinary coverage and a succinct, easy-to-read format make it essential reading for transfusion specialists, as well as practitioners in other specialties whose patients undergo blood transfusions. - Covers the latest advancements in transfusion therapies, hematopoietic stem cells, infectious and non-infectious complications of transfusions, and future directions in transfusion medicine. - Discusses special populations, including organ transplant patients; pediatric, obstetric, and geriatric patients; and patients undergoing emergency care. - Consolidates fundamental clinical concepts and current practice of transfusion medicine into one convenient resource.

This definitive resource from the eminent Oxford Textbooks series, the Oxford Textbook of Anaesthesia addresses the fundamental principles, underpinning sciences and the full spectrum of clinical practice. It brings together the most pertinent research from on-going scientific endeavours with practical guidance and a passion to provide the very best clinical care to patients. This comprehensive work covers all aspects of anaesthesia; volume one addresses the fundamental principles and the basic sciences whose understanding is required for a logical, effective and evidence-based approach to practice. Volume two focuses on the clinical aspects of anaesthesia, including those aspects of intensive care and pain medicine that are required by all general anaesthetists as well as sections dedicated to procedures, surgical specialities, paediatrics, the conduct of anaesthesia outside the theatre, and concurrent disease. In 91 finely crafted and highly illustrated chapters, experts in anaesthesia review the supporting evidence and key techniques for the clinical management of specific conditions and patient groups. International contributors share their research and extensive experience to provide a wealth of practical advice for use in clinical situations in a global context. This essential reference tool supports all anaesthetists seeking an up-to-date and trustworthy account of all aspects of anaesthesia, ideal for reference, study and revision. It will be an indispensable guide to anaesthetists of all grades and subspecialty interest.

Transfusion Medicine provides a concise, clinically focused and practical approach to the field of blood banking and transfusion therapy written by international expert, Jeffrey McCullough MD. Concise, approachable, yet comprehensive approach to the field of transfusion medicine and blood banking Offers extensive guidance on important topics such as; donor recruitment, blood collection and storage, donor testing and clinical uses of blood components, techniques of administration of blood components, complications of transfusion, transmissible diseases, the HLA system, and many more Provides new content on patient blood management systems, the changing indications for red cell transfusion, new transmissible disease agents, management of massive blood loss, pathogen reduced blood components, therapeutic apheresis including photopheresis, management of massive transfusion and new cellular therapies. Discusses global blood supply and US blood supply organizations and their consolidation and reorganization Reviews other topics of current interest, such as mitigation strategies for TRALI prevention, effects of storage of blood on adverse effects, management of massive blood loss and massive transfusion protocols pathogen inactivation, and granulocyte transfusion Extensively referenced for further study

Recognized as the definitive reference in laboratory medicine since 1908, Henry's Clinical Diagnosis continues to offer state-of-the-art guidance on the scientific foundation and clinical application of today's complete range of laboratory tests. Employing a multidisciplinary approach, it presents the newest information available in the field, including new developments in technologies and the automation platforms on which measurements are performed. Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Features a full-color layout, illustrations and visual aids, and an organization based on organ system. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features the latest knowledge on cutting-edge technologies of molecular diagnostics and proteomics. Includes a wealth of information on the exciting subject of omics; these extraordinarily complex measurements reflect important changes in the body and have the potential to predict the onset of diseases such as diabetes mellitus. Coverage of today's hottest topics includes advances in transfusion medicine and organ transplantation; molecular diagnostics in microbiology and infectious diseases; point-of-care testing; pharmacogenomics; and the microbiome. Toxicology and Therapeutic Drug Monitoring chapter discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users.

Clinical Diagnostic Tests is a convenient, quick-reference guide to common errors and pitfalls in test selection and result interpretation for practitioners and trainees in all areas of clinical medicine. Authored by recognized experts and educators in laboratory medicine, it provides timely, practical guidance about what to doóand what not to doófor practitioners ordering or interpreting clinical tests. Each topic features a concise overview and summary followed by a list of bulleted ìstandards of careî that will enable practitioners to quickly recognize and avert a potential problem. Organized for easy access to critical information, this pithy guide addresses all major issues practitioners are likely to encounter during their day-to-day clinical work. It is intended for practitioners in pathology, laboratory medicine, primary care as well as nurse practitioners and physician assistants. It is also a valuable resource for clinical trainees and students who need to learn effective, efficient use of the clinical lab in practice. Key Features: Provides practical guidance for avoiding common errors and pitfalls in lab test selection and interpretation Includes pithy overviews and recommendations for quick reference Written by expert authors and educators in laboratory medicine Presents bulleted ìstandards of careî Serves as a concise, to-the-point teaching guide About the Author: Michael Laposata, MD, PhD, is Chair of Pathology, Director of Division of Laboratory Medicine and Clinical Laboratories, University of Texas Medical Branch, Galveston

The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix

Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human - Organ Systems - Molecular Pathology/Basic Mechanisms of Diseases - Animal Models/Other Model Systems - Experimental Pathology - Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. - Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting - Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of'Normal'and'Disease'anatomy and histology images - Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions

Der „große Reinhardt“ ist seit Jahrzehnten das maßgebliche deutschsprachige Therapiebuch für die Kinder- und Jugendmedizin. Die vollständig überarbeitete und aktualisierte Neuauflage setzt wieder auf das bewährte Kochbuch-Konzept – mit erweitertem Herausgeberteam und der Expertise von zahlreichen neuen Autoren. Die Therapie steht mehr als je zuvor im Fokus des Werks, das sich ganz ohne Ballast, Symptom für Symptom, direkt auf die Therapieprinzipien, die Therapieziele und die einzelnen Therapieschritte konzentriert.Die Vorteile des Buchs sind geblieben:Tipps für die Praxis helfen, Fehlerquellen zu vermeiden und Pitfalls zu umgehen. Therapieanleitungen und Handlungsanweisungen werden genau erläutert und geben Sicherheit. Das Sachverzeichnis und ein zusätzliches Arzneimittelverzeichnis erleichtern die Handhabung im täglichen Gebrauch. Der klare Aufbau jedes Kapitels, aber auch Tabellen und Übersichten sorgen für einen schnellen Zugang zu wichtigen Informationen. Neu aufgenommen wurden u.a. Kapitel zur Organtransplantation, zu Biologika, zur Heimbeatmung und zu Therapiemaßnahmen bei chronisch kranken Kindern.Das große Therapie-Standardwerk der Pädiatrie bleibt mit seinem attraktiven Layout angenehm zu lesen und bietet schnelle Orientierung bei einer Fülle an Informationen. Ein verlässlicher Therapie-Begleiter bei der täglichen Arbeit auf Station oder in der Praxis.

Der Klassiker in Neuauflage! Die'Therapie der Krankheiten im Kindes- und Jugendalter'ist längst zum Standardwerk geworden. Hier finden Sie auf über 1000 Seiten ausführliche Therapiekonzepte und –strategien für Ihre kleinen Patienten. Die 7. Auflage wurde vollständig bearbeitet und erscheint in einem neuen Konzept. Das Wesentliche... - Die strikte Konzentration auf Therapieprinzipien, -ziele und -schritte erspart Ihnen langes Suchen und Blättern - Tipps für die Praxis helfen Ihnen Fehlerquellen zu vermeiden und Stolperfallen zu umgehen - Therapieanleitungen und Handlungsanweisungen geben Ihnen Sicherheit Übersichtlich... - Die durchgehend verbesserte Struktur erleichtert Ihnen die schnelle Orientierung - Hervorgehobene Kernaussagen führen Sie gleich zum Wesentlichen - Therapeutisches Vorgehen wird Schritt für Schritt erläutert Attraktiv... - Das neue, zweifarbige Layout macht das Lesen angenehmer - Zahlreiche Tabellen und Übersichten erleichtern den Zugang zu Informationen'Der Reinhardt'- mit dieser Therapie liegen Sie richtig!

Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field.

Over the past twenty years, the field of carbon structures has been invigorated by the discovery of fullerenes and carbon nanotubes. These nano-structured carbons have attracted a tremendous interest in the fundamental properties of discrete carbon molecules, leading to the discovery of novel complex crystalline and quasi-crystalline materials. As a consequence, a variety of applications have been developed, including technical and bio-medical materials and miniaturized tools.Diamond and Related Nanostructures focuses on the advances in the area of diamond-like carbon nanostructures (hyper-structures built from fullerenes and/or carbon nanotube junctions) and other related carbon nanostructures. Each chapter contributes to the topic from different fields, ranging from theory to synthesis and properties investigation of these new materials. This volume brings together the major findings in the field and provides a source of inspiration and understanding to advanced undergraduates, graduates, and researchers in the fields of Physics, Graph Theory, Crystallography, Computational and Synthetic Chemistry.

Das umfassende Standardwerk zur Transfusionsmedizin liegt nun komplett überarbeitet und aktualisiert in seiner 3. Auflage vor. Systematisch aufgebaut und klar strukturiert wird das Fachgebiet mit allen aktuellen Neuerungen dargestellt: - Grundlagen der Transfusionsmedizin - Therapie mit Blutkomponenten, Plasmaderivaten - Therapie mit Blut und Blutbestandteilen in speziellen klinischen Situationen - Blutsparende Maßnahmen - Unerwünschte Wirkungen von Blutübertragungen Zusätzlich im methodischen Anhang: Nachweise aller relevanten Antigene und deren Antikörper. Das einzige deutschsprachige Werk, welches das Fachgebiet Transfusionsmedizin abdeckt.

The Diagnostic Standards of Care series presents common errors associated with diagnoses in clinical pathology, using case examples to illustrate effective analysis based on current evidence and standards. In addition to being a practical diagnostic guide, each volume demonstrates the use of quality assurance and the role of the pathologist in ensuring quality and patient safety. Transfusion Medicine addresses common issues and errors seen in the blood transfusion process. The goal is to alert general practitioners and trainees to the latest scientific advances and spiraling regulations in blood transfusion as well as introduce them to the most common types of transfusion errors encountered in clinical settings. Transfusion Medicine features: Descriptions of potential errors in regulatory compliance, operational processes, and patient safety Descriptions of potential errors in clinical decision making in blood transfusion, including when to premedicate patients, warfarin reversal, and the diagnostic intricacies in TRALI and TTP Pocket-sized for portability