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Legumes in the structure of fodder crop rotations can cause reducing the efficiency of nitrogen fertilizer application on sod-podzolic soil. A comparative assessment of the productivity of six-field fodder crop rotations with different field number of legume-cereal grasses was carried out on the background of mineral nitrogen application (Р60К60, Ж0Р60К60). The research was carried out in 2013-2017 in crop rotations with 16%, 33% and 50 % legume-cereal grasses saturation in the Mari El Republic. It was noted that one-year extension of period for using perennial legume-cereal grasses in the fodder crop rotations under study was followed by increase in dry matter collection by 1.1-2.1 t/ha, exchange energy - by 6.7-16.5 GJ/ha, and crude protein - by about 2.3-3.7 C/ha. Continuous application of mineral nitrogen led to increasing the productivity of fodder crop rotations with legume-cereal grasses by 9-21%. In crop rotations, target annual and winter crops ensured a significant increase in productivity, with the exception of annual grasses with perennial grasses undersowing in 2013. The greatest increase in productivity was noted in the first crop rotation, where a long-term agrocenosis had been used for 1 year only. The ammonium nitrate application resulted in increase in crude protein collection more than in other productivity indicators of fodder crop rotations target crops.

Associations between IL1B (rs1143634), IL1RN (VNTR, intron 2), IL4 (VNTR, intron 3), TNFA (rs1800629, rs361525), IL6 (rs1800795), and IL10 (rs1800896) genetic polymorphisms in women with recurrent miscarriage (RM) were analyzed. We studied DNA samples of 112 women with RM and 267 women with physiological pregnancy. The IL1RN, IL4 genotypes were identified by PCR techniques, the IL1B, IL6 gene polymorphisms were defined by means of RFLP approach. To detect TNFA and IL10 gene polymorphisms, TaqMan real-time PCR was used. The results have shown that polymorphic loci of IL1B, IL1RN, IL10, TNFA genes were not associated with RM, and early spontaneous abortion risk. The 2R allele of IL4 gene was found to be associated with higher RM risk (OR = 1.52; 95% CI = [1.08-2.14]; P-value (cor) = 0.05), and G allele of IL6 gene was associated with a risk for > 3 early spontaneous abortions (OR = 2.10; 95% CI = [1.24-3.56]; P-value (cor) = 0.05), in an additive inheritance model. Upon evaluation of the data obtained, one may conclude that the IL4 (VNTR intron 3) and IL6 (rs1800795) gene polymorphisms could influence the RM development. These results may be useful for assessment of molecular mechanisms underlying early spontaneous abortion.

In the period 2001...2012 in the experimental field of Mari Agricultural Research Institute the productivity of three fodder crop rotations, galega-bromopsis herbage was evaluated and their effect on soil fertility was determined. The main difference between rotations was in a different saturation with perennial legumes and grasses (I rotation -16,6%, II - 33,0, III - 50,0%) at the application of recommended for the central zone of the Republic of Mari El (N6oP6oK60) and increased (N90P90K90) doses of mineral fertilizers. The results showed that the fertilizer application in crop rotation for 12 years contributed to the increase in the percentage of humus content in soil by 0.4-0.6 %. Оп noncrop rotation area it is observed the largest increase in content of humus in soil; this area was constantly cultivated with herbage of galega-bromopsis grass mixture in the background of recommended and high doses of PK fertilizers. The same increase was in rotations I and III on the background of high doses of NPK. The relationship between the saturation of crop rotations with perennial grasses and a mass fraction of humus in soil were not detected. The acidity of the topsoil in two of the rotation fof odder crop rotation tended to increase by 0.1...0.3 units of pH, significant differences between variants were not detected. The content of phosphorus mobile forms in soil increased by 40-170 mg/kg (5.9 20.2 %) in two rotations and sowing of galega with bromopsis over the study years. A slight downward trend is marked in the potassium content in the soil up to 15 mg/kg (8 %). Increasing the proportion of legumes-cereal grasses to monoculture in the structure of the rotation from 16.6 to 50 % of feed units per unit area on average within 12 years increased to 3.6 %. Input of higher doses of mineral fertilizers over the recommended one leads to increase in productivity by 200.445 fodder units per ha (4.7.11.2%); less addition was obtained at existence of two or three fields of perennial grasses in crop rotation. Use of highest doses of PK-fertilizers in perennial sowing of galega-bromopsis grass mixture allowed highest addition of productivity - 613 fodder units per ha (14.1%).

The purpose of research is to establish K. Horney’s views on psychological problems, by means of theoretical analysis of literature. The term "psychological problem" is not mentioned by Karen Horney, however, she describes emotional, cognitive and behavioral problems of individual components of personality, which allows us to treat the problems as psychological. Emotional, cognitive and behavioral problems are interrelated components that allow us to speak about the specific structure of psychological problems. According to Karen Horney, problems appear due to socio-cultural conditions that create stressful situations for the person (or their environment), their processing depends on the personal characteristics, and in some cases leads to neurosis or psychological problems. Neurosis emerges in the setting of psychological problems and a failed attempt to adapt to them; neurosis can be regarded as a secondary problem on the background of the primary psychological problem. Karen Horney identifies personal problems, problems of work activity, relationship problems and problems associated with the aim. Social issues, particularly the problem of work activity or relationship problems, can occur secondary and result from personal problems. The results obtained show that, in spite of the fact that Karen Horney’s studies did not focus on psychological problems, by comparing problems with a neurosis, she refers to certain types of psychological problems, their causes, mechanisms of occurrence, structure, implications which allows one to highlight the psychological problems as a separate psychological category. The results are expanding the understanding of the matter and may be useful in practical psychology when dealing with clients.

RETRACTED ARTICLEAim. The main purpose of the ecological and biological research (EBR) of the Caspian Sea is the information and technical support of decision-making to ensure the environmental management in the region taking into account the increase of anthropogenic impact and change in climatic conditions.Methods. As a basis, we have adopted the method of theoretical and mathematical generalization of a number of scientific papers and systematic analysis of the proposed solutions.Results. Analysis and mathematical processing of published literature sources has convincingly demonstrated the need for international cooperation to optimize the ecological and biological research. It has also confirmed the usefulness of the ecological and biological studies of the Caspian Sea in different directions, and the distribution of effort (cost) between them requires coordinated management.Conclusion. It is shown that the data obtained by EBI have both rapid and long-term value. In the future, it is rational to develop suitable approaches to unified structuring of the EBR data, including their spatial and timing. An important task is to create a single interstate information space on the results of EBR using information and communication technologies.

Aim. We present materials on the history of hydroacoustic research in the Caspian Sea and forecast of catches in case of abolition of the law prohibiting the fishing in the open sea.Methods. We have carried out three hydroacoustic surveys in accordance with existing procedures. Investigations have been conducted using fish-finding multifunctional sonar panorama video-plotter.Results. Hydroacoustic researches on the density of accumulations, spatial distribution and stocks of Caspian Sea migrating herring (Dolginskaya herring, Caspian and bigeye shads) were carried out in the period of April - May 2007, in the shallow part of the North Caspian Sea, and for this we have performed two hydroacoustic surveys. In the spring, in different areas of surveyed area size and weight characteristics of marine migratory herrings were fairly stable; the length of Dolginskiy herring caught in control fixed nets in different parts of the area surveyed ranged from 23.6 cm. to 30.0 cm, with an average of 26,7 cm; as for the weight, it fluctuated from 212.3g. to 393g, with an average of 275.0 g. These data indicate that the temperature factor is one of the most important abiotic factors that determine the density of accumulations, places and areas of migratory sea herring in the pre-spawning period.Conclusion. Using hydroacoustic sonar method in the Caspian Sea for more than 40 years has shown its representativeness and reliability in assessing marine fish stocks. The number of marine migratory herring in the North Caspian Sea is closely linked to the temperature of the water and with the increase in temperature we can observe increase in the number. The biomass of marine migratory herrings in the Northern Caspian Sea varies from 3 to 5 thousand tons, which is a significant reserve for the fishing industry of Kazakhstan and Russia. Under the current economic conditions the hydroacoustic sonar method is to become a major tool for assessment of fish stocks in the North Caspian.

Aim. To identify the reasons for the decline of fish stocks in the Caspian sea. Location. The Caspian sea. Methods. When adverse effects of multiple abiotic factors, the other part indicates the important role of fisheries. How fair this point of view will try to answer in this paper. Consider long-term changes in the average water temperature in the Northern Caspian sea. Results. Considered abiotic and biological factors ( prey base) productivity of the Northern Caspian sea could cause catastrophic ( tenfold) reduction of fish stocks. Evidence of this is shown in table. 2 which shows that external factors do not provide a clear correlation with the yield of fish, more important are the internal factors related to the impact of fishing. Main conclusions. You should pay very close attention to human factors and in particular on the volume of catch, location and time fishing and more time to assess how rational our modern craft.

There are resulted the ecological bases of a biodiversity saving of the sea-bottom organisms of the Northern Caspian.

There is shown that degradation of plankton is a result of influence of both biotic (mnemiopsis) and abiotic (concentration of mineral nitrogen) factors in the ecosystem of the Middle and South Caspian.

Hydrologo-hydrochemical regime of the Caspian sea, its biological productivity and trophic structure of ecosystem of basin essentially depends on natural-climatic factors forming liquid and biogen flow at water scoop of the basin.

The paper deals with the influence of diffractive optical elements on the optical aberrations. The correction of optical aberrations was investigated in the simple optical systems with one and two lenses (singlet and doublet). The advantages of diffractive optical elements are their ability to generate arbitrary complex wave fronts from a piece of optical material that is essentially flat. The optical systems consisting of the standard surfaces were designed and optimized by using the same starting points. Further, the diffractive and aspheric surfaces were introduced into the developed systems. The resulting hybrid systems were optimized. To compare the complicity of the development of narrow field systems and wide field optical systems, the optimization has been done separately for these two types of the instruments. The optical systems were designed by using special Optical Design Software. Тhe characteristics of designed diffractive surfaces were controlled in Software DIFSYS 2.30. Due to the application of diffractive optical elements the longitudinal chromatic aberration was 5 times reduced for the narrow field systems. The absolute value of Seidel coefficient related to the spherical aberration was reduced in the range of 0.03. Considering that diffractive optical elements have the known disadvantages, like possible parasitic diffraction orders and probable decrease of the transmission, we also developed and analyzed the optical systems with combined aspheric and diffractive surfaces. A combination of the aspheric and diffractive surfaces in the optical disk system of the disk reading lens, gave cutting down of the longitudinal color aberrations almost 15 times on-axis, comparing to the lens consisting of the aspherical and standard surfaces. All of the designed diffractive optical elements possess the parameters within the fabrication limits.

Long-term materials on primary production of phytoplancton of the Northern Caspian sea are considered. The reasons of the fishery production decrease and its trophic status are specified.

There’s made an attempt in the work to estimate the bentos population of the Northern Caspian Sea by mathematic modelling methods. At use of the given method probably considerably to improve the forecast of the general admissible fishes in this area.

In the article is in details considered the technology of investigation and an oil recovery in the eastern part of Northern Caspian Sea. It is shown that the most negative influence will test the benthos of the water area. Materials on structure, seasonal dynamics and biomass of groundorganisms of eastern part of the Northern Caspian Sea are resulted.

Materials on a condition of a phytoplankton, zooplankton and benthos on water areal of Northern average and southern Caspian Sea are resulted.

The article presents materials on the terms of the feeding area of sturgeon in the waters of all the Caspian States.

Materials increases in volume of cultivation proving expediency Stenodus object capable to utilize not used stocks of sea unvaluable fiches are resulted.

Present material justifying the need for a moratorium on hunting the Caspian seal.

The provides long-term data от the state of the medium shallow waters west of the North Caspian.

Data for the last three years on a phytoplankton of Northern Caspian sea is cited in work, the problem of quantity indicators of development of a phytoplankton, long-term dynamics is discussed.

The carrying capacity of the Caspian Sea is estimated in terms of bioresourses.

Calculation potential fishermading has been made and change of this indicator on the given site of Caspian sea is shown.

In the work there is presented mathematic model of counting the fish catching by measuring the seasonal primary production of phytoplankton of the Northern Caspian. The model has shown its representativeness and is offered to use to specialists.

Abstract Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers in solid tumours. This study aimed to interrogate a large real-world database of comprehensive genomic profiling data to describe the genomic landscape and prevalence of NTRK gene fusions. NTRK fusion-positive tumours were identified from the FoundationCORE® database of >295,000 cancer patients. We investigated the prevalence and concomitant genomic landscape of NTRK fusions, predicted patient ancestry and compared the FoundationCORE cohort with entrectinib clinical trial cohorts (ALKA-372-001 [EudraCT 2012-000148-88]; STARTRK-1 [NCT02097810]; STARTRK-2 [NCT02568267]). Overall NTRK fusion-positive tumour prevalence was 0.30% among 45 cancers with 88 unique fusion partner pairs, of which 66% were previously unreported. Across all cases, prevalence was 0.28% and 1.34% in patients aged ≥18 and

Aim: to propose diagnostic algorithm of IgG4-related disease (IgG4-RD). Materials and methods. One center retrospective research. 52 pts with IgG4-RD were included. The diagnosis was proved histologically and immunohistochemically. 48 out of 52 pts received treatment. Treatment included one of the following schemes (along with low oral glucocorticoids): rituximab monotherapy, cyclophosphamide monotherapy or their combination. Results. The mean age was 47.4±5.9 years, the mean age of the disease onset was 43.9±16.0 years. Median time before the diagnosis was 24 months. The most often sites of IgG4-RD were lacrimal (63.5%), salivary (46.2%) glands, lungs (48%), lymph nodes (34.6%) and retroperitoneum (17.3%). In clinical picture the leading complain was organ enlargement, but not its dysfunction. Pain was characteristic for retroperitoneum localization. In 56.8% of pts with IgG4-related syalo - and/or dacryoadenitis there was association with ear - nose - throat organs affection. In 4 pts (7.7%) IgG4-RD was combined with some malignant disease, including MALT-lymphoma of lacrimal glands. Irreversible organ damage as an IgG4-RD outcome had 15.4% of pts. The main laboratory markers of IgG4-RD were ESR elevation (38.5%), blood eosinophilia (9.6%), immunological disturbances (serum total IgG and IgG4 elevation, IgE elevation, antinuclear antibodies, rheumatoid factor detection, hypocomplementemia). Serum IgG4 level >1.35 g/l was elevated in 88% of pts and correlated with the number of affected organs (Spearman correlation coefficient 0.39, Student’s test, р=0.0056). Monoclonal serum secretion and B-cell clonality in the tissue was detected in 4 (23.5%) out of 17 pts, but not all of them had both signs. Conclusion. Based on the analysis of clinical and laboratory characteristics of IgG4-RD a diagnostic algorithm was proposed that enhances the detection and examination of the patients with suspected IgG4-RD.