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2,015 results on '"Dwyer, T."'

172. Social gradient of birthweight in England assessed using the INTERGROWTH-21st gestational age-specific standard

Author

Hirst, JE, Knight, HE, Ohuma, EO, Dwyer, T, Hennig, BD, Papageorghiou, AT, Cheikh Ismail, L, Villar, J, and Kennedy, SH

Subjects
reproductive and urinary physiology
Abstract

OBJECTIVE: To determine the socioeconomic gradient of birthweights in England with reference to the prescriptive INTERGROWTH-21st Birthweight Standard. DESIGN: National cross-sectional study using data from Hospital Episode Statistics. SETTING: National Health Service in England. PARTICIPANTS: All singleton babies, live born between 34 weeks' gestation and 42 weeks' gestation, between 1 April 2011 and 31 March 2012. MAIN OUTCOME MEASURES: Birthweight distribution of babies with a birthweight of 90th centile, that is, small for gestational age (SGA) or large for gestational age (LGA) using Index of Multiple Deprivation quintiles as a proxy for socioeconomic status. RESULTS: Of 508 230 babies born alive between 1 April 2011 and 31 March 2012, 38 838 (7.6%) were SGA and 81 026 (15.9%) were LGA. Median birthweight was 3405 g, median z-score was 0.25 (SD 1.06). Birthweight z-score demonstrated a social gradient, from 0.26 (SD 1.1) in the most deprived areas to 0.53 (1.0) in the least deprived. Women in the most deprived areas were twice as likely to have SGA babies using the INTERGROWTH-21st chart (OR 1.94; 95% CI 1.87 to 2.01) compared with those in the least deprived areas. If all women had the same rate of SGA equivalent to those living in the least deprived areas, approximately 12 410 (30%) fewer babies would be born SGA in England each year. CONCLUSIONS: This study gives a measure of the social gradient in singleton SGA and LGA babies across England using an international standard of newborn size at birth.

Published
2019

174. Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood

Author

Urbina, EM, Khoury, PR, Bazzano, L, Burns, TL, Daniels, S, Dwyer, T, Hu, T, Jacobs, DR, Juonala, M, Prineas, R, Raitakari, O, Steinberger, J, Venn, A, Woo, JG, and Sinaiko, A

Subjects
Adult, Male, Adolescent, Blood Pressure, Blood Pressure Determination, United States, Article, Body Mass Index, Young Adult, Risk Factors, Hypertension, Disease Progression, Prevalence, Humans, Female, Self Report, Child, Life Style, Follow-Up Studies, Retrospective Studies
Abstract

Blood pressure (BP) tracking (maintaining a BP percentile) across life is not well defined but is important in predicting which children will become hypertensive adults. We computed BP tracking in subjects with BP measured in childhood and adulthood and performed logistic regression to determine the ability of childhood BP to predict adult hypertension (N=5035, 46.7 years, 74.2% white, 17.7% black; 39.6% male). Prevalence of hypertension was 29%. Correlations between systolic BP for child and adolescent were r=0.48; for adolescent and young adult were r=0.40, and for child and young adult were r=0.24 (all P

Published
2019
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180. SAT0580

Author

Meng, T, Venn, A, Eckstein, F, Wirth, W, Cicuttini, F, March, L, Dwyer, T, Cross, M, Laslett, L, Jones, G, Ding, C, and Antony, B

Published
2019
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181. Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96 706 UK Biobank participants

Author

Barker, J, Karl, S, Doherty, A, Foster, C, Rahimi, K, Ramakrishnan, R, Woodward, M, and Dwyer, T

Subjects
Physical activity, Accelerometry, Chronic Disease, SPS Exercise, Nutrition and Health Sciences
Abstract

Background Physical inactivity is associated with an increased risk of major chronic diseases, however uncertainty exists about which chronic diseases, themselves, might contribute to physical inactivity. The objective of this study was to compare the physical activity of those with chronic diseases to healthy individuals using an objective measure of physical activity. Methods We conducted a cross-sectional analysis of data from 96 706 participants aged 40 years or older from the UK Biobank prospective cohort study (2006 – 2010). Diagnoses were identified through ICD 9 and 10 coding within hospital admission records and cancer registry linked to UK Biobank participants. We extracted summary physical activity information from participants who wore a wrist-worn triaxial accelerometer for seven days. Statistical analyses included computation of adjusted geometric means and means using general linear models. Results Participants with chronic disease undertook 9% or 61 minutes (95% confidence interval [CI]: 57.8-64.8) less moderate activity and 11% or three minutes (95% CI: 2.7-3.3) less vigorous activity per week than individuals without chronic disease. Participants in every chronic disease subgroup took less physical activity than those without chronic disease. Sixty-seven diagnoses within these subgroups were associated with lower moderate activity. Conclusions The cross-sectional association of physical activity with chronic disease is broad. Given the substantial health benefits of being physically active, clinicians and policymakers should be aware that their patients with any chronic disease are at greater health risk from other diseases than anticipated because of their physical inactivity.

Published
2019
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182. MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

Author

Pellegrini, C. Botta, F. Massi, D. Martorelli, C. Facchetti, F. Gandini, S. Maisonneuve, P. Avril, M.-F. Demenais, F. Bressac-de Paillerets, B. Hoiom, V. Cust, A.E. Anton-Culver, H. Gruber, S.B. Gallagher, R.P. Marrett, L. Zanetti, R. Dwyer, T. Thomas, N.E. Begg, C.B. Berwick, M. Puig, S. Potrony, M. Nagore, E. Ghiorzo, P. Menin, C. Manganoni, A.M. Rodolfo, M. Brugnara, S. Passoni, E. Sekulovic, L.K. Baldini, F. Guida, G. Stratigos, A. Ozdemir, F. Ayala, F. Fernandez-de-Misa, R. Quaglino, P. Ribas, G. Romanini, A. Migliano, E. Stanganelli, I. Kanetsky, P.A. Pizzichetta, M.A. García-Borrón, J.C. Nan, H. Landi, M.T. Little, J. Newton-Bishop, J. Sera, F. Fargnoli, M.C. Raimondi, S. Alaibac, M. Ferrari, A. Valeri, B. Sicher, M. Mangiola, D. Nazzaro, G. Tosti, G. Mazzarol, G. Giudice, G. Ribero, S. Astrua, C. Mazzoni, L. Orlow, I. Mujumdar, U. Hummer, A. Busam, K. Roy, P. Canchola, R. Clas, B. Cotignola, J. Monroe, Y. Armstrong, B. Kricker, A. Litchfield, M. Tucker, P. Stephens, N. Switzer, T. Theis, B. From, L. Chowdhury, N. Vanasse, L. Purdue, M. Northrup, D. Rosso, S. Sacerdote, C. Leighton, N. Gildea, M. Bonner, J. Jeter, J. Klotz, J. Wilcox, H. Weiss, H. Millikan, R. Mattingly, D. Player, J. Tse, C.-K. Rebbeck, T. Walker, A. Panossian, S. Setlow, R. Mohrenweiser, H. Autier, P. Han, J. Caini, S. Hofman, A. Kayser, M. Liu, F. Nijsten, T. Uitterlinden, A.G. Kumar, R. Bishop, T. Elliott, F. Lazovich, D. Polsky, D. Hansson, J. Pastorino, L. Gruis, N.A. Bouwes Bavinck, J.N. Aguilera, P. Badenas, C. Carrera, C. Gimenez-Xavier, P. Malvehy, J. Puig-Butille, J.A. Tell-Marti, G. Blizzard, L. Cochrane, J. Branicki, W. Debniak, T. Morling, N. Johansen, P. Mayne, S. Bale, A. Cartmel, B. Ferrucci, L. Pfeiffer, R. Palmieri, G. Kypreou, K. Bowcock, A. Cornelius, L. Council, M.L. Motokawa, T. Anno, S. Helsing, P. Andresen, P.A. Guida, S. Wong, T.H. IMI Study Group GEM Study Group M-SKIP Study Group

Abstract

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. Findings: We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02–2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06–3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05–2·44; p=0·04) and Asp294His (2·15, 1·05–4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. Interpretation: Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. Funding: SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831. © 2019 Elsevier Ltd

Published
2019

183. Preface

Author

Chang, R, Dwyer, T, Fujishiro, I, Isenberg, P, Franconeri, S, Qu, H, Schreck, T, Weiskopf, D, and Weber, GH

Subjects
Computation Theory And Mathematics, Software Engineering, Artificial Intelligence And Image Processing
Published
2019
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191. Sylvester O’halloran surgical scientific meeting: Proceedings of meeting held march 11th & 12th, 1994 in the John Holland theatre, university of Limerick.

Author

Barry, M. C., Burke, P., Joyce, W. P., Sheehan, S., Broe, P., Bouchier-Hayes, D., Mccollum, P. T., Holdsworth, R. I., Stonebridge, P. A., Belch, J. J., O≿suilleabhain, C., Waldron, D., Hehir, D., O≿donnell, J. A., Brady, M. P., Kelly, J., O≿donnell, J., Morasch, M. D., Couse, N. F., Colgan, M. P., Moore, D. J., Shanik, G. D., Russell, J. D., O≿dwyer, T. P., Russell, J., Walsh, M., Lennon, G. M., Sweeney, P., Grainger, R., Mcdermott, T. E. D., Thornhill, J. A., Butler, M. R., Vashisht, R., Koppikar, M., Rogers, H. S., Stokes, M. A., Carroll, T., Regan, M. C., Fitzpatrick, J. M., Gorey, T. F., Mccarthy, J., Redmond, H. P., Duggan, S., Watson, R. W. G., O≿donnel, R., Clements, W. D. B., Mccaigue, M. D., Halliday, I. M., Rowlands, B. J., O≿hanlon, D., Kerin, M., Kent, P., Grimes, H., Maher, D., Given, H. F., Keogh, I., Given, H. F., McAnena, O., O≿hanlon, D. M., Chin, D., Mccarthy, P., Kennedy, S., Dolan, J., Mercer, P., Mcdermott, E. W., Duffy, M. J., O≿higgins, N. J., Delaney, C. P., Mcgeeney, K. F., Dolan, S., Campbell, C., Mccluggage, G., Halliday, M. I., Khan, F., Delaney, P., Barrett, N., Morrin, M., Ma, Q. Y., Anderson, N. H., Magee, G. D., Norwood, W., Meagher, P. J., Kelly, C. J., Deasy, J. M., Baldota, S., Jakoubek, F., Mcloughlin, H., Eustace, P. W., Waldron, R., Johnston, J. G., Shuaib, I., Strunz, B., Hall, T., Williams, N., Delaney, P. V., Donnelly, V. S., O≿herlihy, C., O≿connell, P. R., Walsh, M., Attwood, S. E. A., Evoy, D. A., Boyle, B., Brown, S., Stephens, R. B., Gillen, P., Attwood, S., Tanner, W. A., Keane, F. B. V., Morris, S., Reid, S., Neary, P., Horgan, P., Traynor, O., Hyland, J., Barrett, J., Collins, J. K., O≿sullivan, G., Boyle, T. J., Lyerly, J. K., Gallagher, H. J., Naama, H., Shou, J., Daly, J. M., Wang, J. H., Barclay, R. G., Creagh, T., Smalley, T., Waters, C., Mundy, A. R., Campbell, G. R., Stokes, K., Kelly, C., Abdih, H., Bouchier Hayes, D., Loughnane, F., Ahearne, M., Akram, M., Drumm, J., Collins, G. N., Mulvin, D., Malone, F., Kelly, D., Delaney, C., Mckeever, J., Mehigan, D., Keaveny, T. V., Hennessy, A., Grace, P., Mcgee, H., Boyle, C. A. O., Mohan, P., Cross, K. S., Feeley, T. M., O≿donoghue, J. M., Al-Ghazal, S. K., Mccann, J., Regan, M., Stokes, M., Graham, F., Young, L., Flanagan, F., Ennis, J., Fitzpatrick, J., Gorey, T., Walsh, S., Callahan, J., Macgowan, S. W., Malone, C., Young, L. S., Wood, A. E., Madhavan, P., O≿sullivan, R., Durkan, M., Nyhan, T., Lynch, G., Egan, J., Mcavinchey, D., and Bulle, B.

Published
1994
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192. Cotinine validation of self-reported smoking in commercially run community surveys

Author

Pierce, JP, Dwyer, T, DiGiusto, E, Carpenter, T, Hannam, C, Amin, A, Yong, C, Sarfaty, G, Shaw, J, Burke, N, and Committee, Quit For Life Steering

Subjects
Public Health, Health Sciences, Prevention, Tobacco Smoke and Health, Substance Misuse, Tobacco, Cancer, Respiratory, Adolescent, Adult, Aged, Australia, Cotinine, Data Collection, Female, Humans, Male, Middle Aged, Pyrrolidinones, Regression Analysis, Saliva, Sampling Studies, Smoking
Abstract

A validation study was carried out on self-reported smoking for 1177 people in Sydney and Melbourne in 1983. Because of its long half life and the fact that smoking is its only source in body fluids, saliva cotinine was chosen as the validation measure. Cotinine levels above 250 nmol/l were used to classify people as smokers. The sensitivity of self-reported smoking was 92.6% and the specificity was 93.4%. There was some evidence that people in the process of changing their smoking status might be slow in updating their self-classification. The smoking prevalence estimate based on cotinine levels was found to be 1.7% lower than that for self-reported smoking status. The small proportion of false negatives and false positives suggests that commercially collected data banks can be valid sources of prevalence data. Correlation between cotinine level and reported cigarette consumption was not affected by sample volume, and was similar to that achieved for carbon monoxide and thiocyanate at a low 0.34. Regression analysis using self-reported cigarette consumption filter/non-filter cigarettes, and time since last cigarette as predictors, explained 13.6% of the variance in cotinine level.

Published
1987

193. Evaluation of the Sydney "Quit. For Life" anti-smoking campaign. Part 1. Achievement of intermediate goals.

Author

Pierce, JP, Dwyer, T, Frape, G, Chapman, S, Chamberlain, A, and Burke, N

Subjects
Humans, Recurrence, Follow-Up Studies, Random Allocation, Health Education, Time Factors, Advertising, Television, Adolescent, Adult, Aged, Middle Aged, Australia, Female, Male, Evaluation Studies as Topic, Surveys and Questionnaires, Smoking Prevention, Tobacco Control, Smoking, Mass Media Campaign, General & Internal Medicine, Public Health and Health Services, Clinical Sciences, Psychology, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

The "Quit. For Life" campaign was a media-based programme that was aimed at reducing the prevalence of smoking in Sydney. The programme committee set four intermediate goals which it felt had to be met for such a change in prevalence to occur. From households selected at random in Sydney and Melbourne, 5713 people were interviewed to assess whether the campaign attained these goals. The television commercials that were designed for the campaign, their frequency and the timing of their screening produced a higher recall of the commercial's message and the use of campaign back-up services than were specified originally in the goals. During the campaign there was a progressive increase in the number of smokers in Sydney who reported that they were likely to quit; this was significantly different from Melbourne data by the end of the campaign and thus fulfilled another campaign goal. However, shortly after the campaign ended, the proportion of smokers who intended to quit smoking was the same in the two cities. A cohort study of 949 people from the baseline study showed that, during the 12-month period of follow-up, 66% of Sydney smokers tried to stop or to reduce their smoking. In the control city, Melbourne, 60% of smokers reported making such attempts. Of the original smokers, 23% in Sydney and 9% in Melbourne quit during the follow-up period--a statistically significant difference. As well, 10% of the original ex-smokers in Sydney and 11% in Melbourne relapsed, while 4% of nonsmokers in both cities began smoking by the end of the second survey.

Published
1986

194. Evaluation of the Sydney "Quit. For Life" anti-smoking campaign. Part 2. Changes in smoking prevalence.

Author

Dwyer, T, Pierce, JP, Hannam, CD, and Burke, N

Subjects
Saliva, Humans, Cotinine, Follow-Up Studies, Cross-Sectional Studies, Random Allocation, Interview, Psychological, Sex Factors, Time Factors, Advertising, Adolescent, Adult, Aged, Middle Aged, Australia, Female, Male, Evaluation Studies as Topic, Surveys and Questionnaires, Smoking Prevention, Smoking Prevalence, Mass Media Campaign, Tobacco Control, General & Internal Medicine, Public Health and Health Services, Clinical Sciences, Psychology, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

Between June and November 1983, the "Quit. For Life" media campaign was conducted in Sydney to reduce the prevalence of smoking. Surveys on a cross-sectional sample of the Sydney population were conducted before and after the campaign, and similar measures were undertaken in the rest of Australia for comparison. The sample sizes for both the Sydney and control areas comprised more than 4000 subjects. In addition, a cohort of 949 residents of Sydney and Melbourne were followed for changes in the prevalence of smoking during the year of the campaign. The cross-sectional survey results for 1984 and 1983 demonstrated decreases in the prevalence of smoking of approximately 1% for both men and women in Sydney compared with the rest of Australia. In the cohort study there was a 3.4% decrease in smoking prevalence in Sydney compared with a 0.8% increase in Melbourne. The pooled estimate of the difference in smoking prevalence attributable to the campaign was 2.8% (95% confidence interval, 0.5%-5.1%).

Published
1986

198. Child Health CheckPoint: cohort summary and methodology of a physical health and biospecimen module for the Longitudinal Study of Australian Children

Author

Clifford, Susan A., Davies, Sarah, Wake, Melissa, Azzopardi, P.S., Baur, L.A., Burgner, D.P., Carlin, J.B., Cheung, M., Dwyer, T., Edwards, B., Ellul, S., Gillespie, A.N., Gold, Lisa, Grobler, A.C., Kerr, J.A., Lycett, Kate, Lange, K., Mensah, F.K., Olds, T.S., Ranganathan, S., Rogers, H., Saffery, R., Sawyer, M., Simm, P.J., Stevens, L., Wong, T.Y., Zubrick, S.R., Clifford, Susan A., Davies, Sarah, Wake, Melissa, Azzopardi, P.S., Baur, L.A., Burgner, D.P., Carlin, J.B., Cheung, M., Dwyer, T., Edwards, B., Ellul, S., Gillespie, A.N., Gold, Lisa, Grobler, A.C., Kerr, J.A., Lycett, Kate, Lange, K., Mensah, F.K., Olds, T.S., Ranganathan, S., Rogers, H., Saffery, R., Sawyer, M., Simm, P.J., Stevens, L., Wong, T.Y., and Zubrick, S.R.

Published
2019

199. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Author

Küpers, LK, Monnereau, C, Sharp, GC, Yousefi, P, Salas, LA, Ghantous, A, Page, CM, Reese, SE, Wilcox, AJ, Czamara, D, Starling, AP, Novoloaca, A, Lent, S, Roy, R, Hoyo, C, Breton, CV, Allard, C, Just, AC, Bakulski, KM, Holloway, JW, Everson, TM, Xu, C-J, Huang, R-C, van der Plaat, DA, Wielscher, M, Merid, SK, Ullemar, V, Rezwan, FI, Lahti, J, van Dongen, J, Langie, SAS, Richardson, TG, Magnus, MC, Nohr, EA, Xu, Z, Duijts, L, Zhao, S, Zhang, W, Plusquin, M, DeMeo, DL, Solomon, O, Heimovaara, JH, Jima, DD, Gao, L, Bustamante, M, Perron, P, Wright, RO, Hertz-Picciotto, I, Zhang, H, Karagas, MR, Gehring, U, Marsit, CJ, Beilin, LJ, Vonk, JM, Jarvelin, M-R, Bergström, A, Örtqvist, AK, Ewart, S, Villa, PM, Moore, SE, Willemsen, G, Standaert, ARL, Håberg, SE, Sørensen, TIA, Taylor, JA, Räikkönen, K, Yang, IV, Kechris, K, Nawrot, TS, Silver, MJ, Gong, YY, Richiardi, L, Kogevinas, M, Litonjua, AA, Eskenazi, B, Huen, K, Mbarek, H, Maguire, RL, Dwyer, T, Vrijheid, M, Bouchard, L, Baccarelli, AA, Croen, LA, Karmaus, W, Anderson, D, de Vries, M, Sebert, S, Kere, J, Karlsson, R, Arshad, SH, Hämäläinen, E, Routledge, MN, Boomsma, DI, Feinberg, AP, Newschaffer, CJ, Govarts, E, Moisse, M, Fallin, MD, Melén, E, Prentice, AM, Kajantie, E, Almqvist, C, Oken, E, Dabelea, D, Boezen, HM, Melton, PE, Wright, RJ, Koppelman, GH, Trevisi, L, Hivert, M-F, Sunyer, J, Munthe-Kaas, MC, Murphy, SK, Corpeleijn, E, Wiemels, J, Holland, N, Herceg, Z, Binder, EB, Davey Smith, G, Jaddoe, VWV, Lie, RT, Nystad, W, London, SJ, Lawlor, DA, Relton, CL, Snieder, H, Felix, JF, Küpers, LK, Monnereau, C, Sharp, GC, Yousefi, P, Salas, LA, Ghantous, A, Page, CM, Reese, SE, Wilcox, AJ, Czamara, D, Starling, AP, Novoloaca, A, Lent, S, Roy, R, Hoyo, C, Breton, CV, Allard, C, Just, AC, Bakulski, KM, Holloway, JW, Everson, TM, Xu, C-J, Huang, R-C, van der Plaat, DA, Wielscher, M, Merid, SK, Ullemar, V, Rezwan, FI, Lahti, J, van Dongen, J, Langie, SAS, Richardson, TG, Magnus, MC, Nohr, EA, Xu, Z, Duijts, L, Zhao, S, Zhang, W, Plusquin, M, DeMeo, DL, Solomon, O, Heimovaara, JH, Jima, DD, Gao, L, Bustamante, M, Perron, P, Wright, RO, Hertz-Picciotto, I, Zhang, H, Karagas, MR, Gehring, U, Marsit, CJ, Beilin, LJ, Vonk, JM, Jarvelin, M-R, Bergström, A, Örtqvist, AK, Ewart, S, Villa, PM, Moore, SE, Willemsen, G, Standaert, ARL, Håberg, SE, Sørensen, TIA, Taylor, JA, Räikkönen, K, Yang, IV, Kechris, K, Nawrot, TS, Silver, MJ, Gong, YY, Richiardi, L, Kogevinas, M, Litonjua, AA, Eskenazi, B, Huen, K, Mbarek, H, Maguire, RL, Dwyer, T, Vrijheid, M, Bouchard, L, Baccarelli, AA, Croen, LA, Karmaus, W, Anderson, D, de Vries, M, Sebert, S, Kere, J, Karlsson, R, Arshad, SH, Hämäläinen, E, Routledge, MN, Boomsma, DI, Feinberg, AP, Newschaffer, CJ, Govarts, E, Moisse, M, Fallin, MD, Melén, E, Prentice, AM, Kajantie, E, Almqvist, C, Oken, E, Dabelea, D, Boezen, HM, Melton, PE, Wright, RJ, Koppelman, GH, Trevisi, L, Hivert, M-F, Sunyer, J, Munthe-Kaas, MC, Murphy, SK, Corpeleijn, E, Wiemels, J, Holland, N, Herceg, Z, Binder, EB, Davey Smith, G, Jaddoe, VWV, Lie, RT, Nystad, W, London, SJ, Lawlor, DA, Relton, CL, Snieder, H, and Felix, JF

Abstract

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.

Published
2019

200. On the Inside: 40 Years of Prisoner (Cell Block H) at the St Kilda Film Festival, Melbourne

Author

O'Meara, R, Taylor, S, Dwyer, T, Batty, C, O'Meara, R, Taylor, S, Dwyer, T, and Batty, C

Abstract

On June 25 a capacity crowd met at the St Kilda Town Hall in Melbourne – the city that is the home of iconic Australian television series Prisoner (1979-1986) – to celebrate 40 years since the show made its debut on Australia’s Network 10. Prisoner’s extraordinary 692-episode run is made more remarkable by the fact that it was commissioned as a 16-part standalone series. It has since spawned international remakes and reimaginings, perhaps most notably Wentworth (2013-), now in its seventh season.

Published
2019

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