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Intergender differences in auditory brain stem response (ABR) latencies have been attributed to intergender differences in head size. We examined ABR data obtained clinically and head dimensions measured from mastoid to mastoid and mastoid to vertex to derive horizontal and vertical vectors which might scale lengths of horizontally and vertically oriented pathways, respectively. Correlations with ABR latencies were all somewhat weak, and slopes of regressions were found to be too small to fully account for intergender latency differences. Head-size matched male and female samples also demonstrated significant differences in wave V latency, and, even in cases with relatively large heads, the use of a head-size correction could not be justified. The coupling between head dimensions and the I-V interpeak interval appears to be small enough to be ignored for clinical purposes. Nevertheless, to the extent to which relationships exist between head dimensions and ABR latency measures, this nonpathologic variable may be completely neutralized through the use of interpeak latency ratios (e.g., wave V latency divided by wave I latency).

Two-channel recordings of the brain stem auditory evoked potential (BAEP), for example, forehead to ipsilateral mastoid and forehead to contralateral mastoid, presumably provide "views" of the generators from different, nearly orthogonal, directions. The two channels thus are expected to register somewhat different waveforms, as revealed by past research. Still, the absolute latencies of the peaks are expected to be strongly correlated between channels. To test this notion, correlation analyses were made of the latencies of positive and negative peaks of normal-appearing BAEPs. The results demonstrated the expected high correlations for brain stem components but less tight coupling between peaks of waves of more peripheral origins. The possible influence of residual noise also was considered. Implications of the findings for clinical and multichannel recording applications are discussed.

Brain-stem auditory evoked potentials (BAEPs) were elicited by bone conducted stimuli in the very immature lamb following delivery, wherein liquid ventilation techniques were utilized to control cardiopulmonary and acid-base conditions, independent of umbilical-placenta support. Unlike previous studies of the in utero fetal lamb in which the BAEP could not be elicited by earphone delivered stimuli until 117 days gestation, our results demonstrate that the BAEP emerges at least as early as 106 days gestation in the lamb and consists of a full complement of readily discernible and reproducible wave forms. In addition, the results demonstrate substantial maturation of the BAEP from 106 to 122 days gestation during which time there is a significant decrease in absolute and interpeak latencies with an increase in developmental age. It is concluded that the ability to elicit the BAEP utilizing bone conduction at this early stage of gestation is related to improved stimuli delivery. Furthermore, this study demonstrates the feasibility and flexibility afforded by liquid ventilation and bone conduction BAEP techniques to study brain-stem function at particularly vulnerable stages of development.

The late auditory evoked potential (AEP) was studied in response to an alternatingly frequency-modulated complex tone. This 'pattern-reversal' AEP was found to be a heartier response than the more conventional tone-burst evoked potential, albeit longer in latency.

We evaluated a 25-year-old woman with multiple sclerosis who presented with the acute onset of a profound unilateral high-frequency, sensorineural hearing loss that resolved clinically within 10 days. Click-elicited brain stem-evoked responses were abnormal at the time of presentation and demonstrated only limited recovery over a follow-up period of 11 months. Magnetic resonance imaging disclosed a lesion in the eighth nerve root-entry zone and the cochlear nucleus. Our findings in this case support the hypothesis of eighth nerve root-entry zone involvement in sudden hearing loss in multiple sclerosis and reinforce the notion that click-elicited brain stem-evoked responses are useful primarily to evaluate the high-frequency regions of the auditory system.

This paper describes the design of software that will be used as part of an interactive video programme for the training of otolaryngologists. Although the construction of the programme is still in progress, some insight is given into the process by which the ideas were first developed and the production and evaluation of the prototype software. The procedure chosen was stapedectomy.

Observations from clinical and research applications of brain stem evoked response audiometry and electrocochleography have suggested that tone bursts of only a few milliseconds' duration can elicit frequency specific responses. Because such brief stimuli are not perceived as being total, the extent to which the auditory system can "tune" to such stimuli was questioned. In order to investigate this question, psychophysical tuning functions were determined for brief tone bursts (i.e., 1. to 2 msec. duration). The results suggest that in working near normal thresholds (and therefore at relatively low sound pressure levels), brief tone bursts do yield rather frequency specific information. However, the range of sound pressure levels of the stimulus for which the tuning is resonably sharp is limited. the tuning functions show signs of deterioration, particularly in the "tip region," with only modest increases in the sound pressure level above threshold (i.e., typically with 20 dB.). Differences also may be seen between tuning functions for these very brief tone bursts, which in turn are characterized by a so-called click pitch, and those of stimuli long enough to have tonal pitch (i.e., 20 msec.). Finally, tuning functions also were examined for click stimulation, which also revealed some degree of tuning at relatively low levels of stimulation.

Human subjects with and without profound bilateral vestibular loss were evaluated using repetitive rotational stimulation about an earth-vertical axis and signal averaging of vertex-recorded potentials. The stimulus events to which averaging was synchronized were acceleration/deceleration pulses produced by abrupt reversals in direction of angular velocity. In control subjects the long-latency rotational evoked potentials elicited via this paradigm were robust and reproducible. The responses of subjects with vestibular loss did not differ remarkably from those of the control subjects. We conclude that the long-latency rotational evoked potential elicited using a conventional rotary chair is not primarily of vestibular origin.

The late auditory-evoked potential (AEP) was studied in response to a frequency-modulated complex synthesized from discrete tones, somewhat analogous to visual stimulation using reversals of alternating light and dark stripes. The "pattern-reversal' AEP was found to be a heartier response than the familiar transient-evoked AEP (e.g. tone-burst-elicited potential), but the latencies of the component potentials were longer. The apparent enhancement of the AEP is postulated to be due to response summation across critical bands, akin perhaps to loudness growth as stimulus bandwidth increases.

Utilizing the differential recording technique, microphonic isopotential measurements were carried out before and after overstimulation. Recordings were made in the first and third turns of guinea pig cochleas. The exposure stimuli were pure tones of frequencies near the best frequency of the recording site. The results were suggestive of differences in the effects of overstimulation in different turns of the cochlea, at least as they are manifested electrophysiologically.

Summating potentials (SP) were recorded in the guinea pig cochlea, utilizing the differential-electrode technique. The effects of biasing the cochlear partition of the SP were observed under three different conditions: 1. electrical biasing--direct current polarization: 2. stimulus biasing--mechanical bias induced by low frequency sound stimulation, 3. COCB biasing--electrical stimulation of the crossed olivo-cochlear bundle. All three forms of biasing were found to have similar ellects on the SP which can be described in terms of the "absolute direction of change" in the potential. Under negative current (scala vestibuli negative; scala tympani positive), the negative phase of the stimulus bias (deflection of the cochlear partition towards scala vestibuli), or stimulation of the COCB, the SP is made more positive or less negative, as the case may be. In other words, the negative component of the differentially recorded SP is depressed, wheras the positive component is enhanced. The dominant influence os all three forms of biasing appears to be on mechanoelectric distortion arising in the hair-cell transduction process.

The high reliability with which the waves I through V can be identified in auditory brain stem potential (BAEP) recordings suggests the possibility of using the computer to identify the peaks. This paper examines the application of a smoothing algorithm in which detection of zero crossings in the derivative array of the averaged potentials is used to identify waves I--V in clinical BAEP recordings. A comparison of computer wave identification with human evaluation is presented. The results suggest that computer evaluation cannot entirely replace 'manual' evaluation of the waves, but can expedite analysis and alert the clinician to potentially abnormal responses.

A comparison was made of the whole-nerve action potential recorded from a wire electrode placed on the tympanic membrane (TM) (remote extracochlear recording) and than recorded from intracochlear electrodes in the first and third turn scala tympani of the guinea pig. Cochlear microphonics and summating potentials were also studied. The expected decreased sensitivity at the TM site was observed in all responses, although the microphonic (CM) was diminished more that the action potential (AP) as compared to the responses monitored via the ST1 electrode. Nevertheless, the TM-recorded cochlear potentials largely mimicked the ST1-recorded potentials in a qualitative manner, i.e., similar configurations of the CM pseudo-threshold functions. It was consistently observed that the N2 of the AP is proportionally larger (relative to N1) in the TM recording than in the ST1 recording. These phenomena were attributed to the complex spread of the bioelectrical potentials in the nonhomogeneous volume conductor formed by the tissues of the temporal bone. It was suggested that the observed change in the N1/N2 ratio at the different sites of recording is due to the different contributions of second-order neuronal discharges to the compound AP. In effect, the TM electrode "sees" proportionally more activity from second-order fibers than does the ST1 electrode, and the ST3 electrode, less.

The binaural masking level difference (MLD) was measured at multiple masking levels (i.e. 500 Hz narrow band noise presented at 50-100 dB overall SPL) in normal hearing subjects and clinical subjects with varying types and degrees of hearing loss. MLD versus noise level (MLD-NL) functions then were derived for each subject. Some growth in the MLD-NL was seen in nearly all cases of hearing loss up to 70 dB in the poorer ear. These findings suggest that the MLD-NL function may provide the basis for extending the diagnostic usefulness of the MLD test in cases of substantive hearing loss.

The cochlear microphonic response was measured with differential electrodes from the first and third cochlear turns of normal guinea pigs and those treated with the ototoxic drug kanamycin. Histological controls showed that the outer hair cells in treated animals were missing over the basal half of the damaged cochleas, while the inner hair cells were intact. Measurements are consistent with the hypothesis that the potentials produced by inner hair cells are proportional to the velocity of the basilar membrane, whereas potentials generated by outer hair cells (which dominate the response of normal cochleas) are proportional displacement of the basilar membrane.