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151. Prognostic and Therapeutic Implications of Statin and Aspirin Therapy in Individuals With Nonobstructive Coronary Artery Disease

Author

Chow, Benjamin J.W., primary, Small, Gary, additional, Yam, Yeung, additional, Chen, Li, additional, McPherson, Ruth, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cheng, Victor Y., additional, Chinnaiyan, Kavitha, additional, Cury, Ricardo, additional, Delago, Augustin, additional, Dunning, Allison, additional, Feuchtner, Gundrun, additional, Hadamitzky, Martin, additional, Hausleiter, Jörg, additional, Karlsberg, Ronald P., additional, Kaufmann, Philipp A., additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, LaBounty, Troy, additional, Lin, Fay, additional, Maffei, Erica, additional, Raff, Gilbert L., additional, Shaw, Leslee J., additional, Villines, Todd C., additional, and Min, James K., additional

Published
2015
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152. A Clinical Model to Identify Patients With High-Risk Coronary Artery Disease

Author

Yang, Yelin, primary, Chen, Li, additional, Yam, Yeung, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cheng, Victor Y., additional, Chinnaiyan, Kavitha, additional, Cury, Ricardo, additional, Delago, Augustin, additional, Dunning, Allison, additional, Feuchtner, Gudrun, additional, Hadamitzky, Martin, additional, Hausleiter, Jörg, additional, Karlsberg, Ronald P., additional, Kaufmann, Philipp A., additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, LaBounty, Troy, additional, Lin, Fay, additional, Maffei, Erica, additional, Raff, Gilbert L., additional, Shaw, Leslee J., additional, Villines, Todd C., additional, Min, James K., additional, and Chow, Benjamin J.W., additional

Published
2015
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153. Coronary dominance and prognosis in patients undergoing coronary computed tomographic angiography: results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry

Author

Gebhard, Catherine, primary, Fuchs, Tobias A., additional, Stehli, Julia, additional, Gransar, Heidi, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha M., additional, Chow, Benjamin J. W., additional, Cury, Ricardo C., additional, Delago, Augustin, additional, Gomez, Millie J., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Hindoyan, Niree, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, Lin, Fay Y., additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Shaw, Leslee J., additional, Villines, Todd C., additional, Dunning, Allison M., additional, Min, James K., additional, and Kaufmann, Philipp A., additional

Published
2015
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154. Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM)

Author

Ahmadi, Amir, primary, Leipsic, Jonathon, additional, Feuchtner, Gudrun, additional, Gransar, Heidi, additional, Kalra, Dan, additional, Heo, Ran, additional, Achenbach, Stephan, additional, Andreini, Daniele, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew, additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin, additional, Cury, Ricardo C., additional, Delago, Augustin, additional, Gomez, Millie J., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Hindoyan, Niree, additional, Kaufmann, Philipp A., additional, Kim, Yong-Jin, additional, Lin, Fay, additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert L., additional, Shaw, Leslee J., additional, Villines, Todd C., additional, Dunning, Allison, additional, and Min, James K., additional

Published
2015
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156. STATINS AND EXERCISE TRAINING RESPONSE IN HEART FAILURE PATIENTS: INSIGHTS FROM THE HF-ACTION TRIAL

Author

Kelly, Jacob P., primary, Mentz, Robert, additional, Schulte, Phillip, additional, Dunning, Allison, additional, Fiuzat, Mona, additional, Keteyian, Steven, additional, Fleg, Jerome, additional, Leifer, Eric, additional, Pina, Ileana, additional, Cooper, Lawton, additional, Kitzman, Dalane, additional, Kraus, William, additional, Whellan, David, additional, and O’Connor, Christopher, additional

Published
2015
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157. ARE THERE SEX DIFFERENCES IN ADVERSE OUTCOMES ASSOCIATED WITH THE SEVERITY OF CORONARY DISEASE DIAGNOSED BY CARDIAC COMPUTED TOMOGRAPHY? AN ANALYSIS FROM THE CONFIRM REGISTRY

Author

Schulman-Marcus, Joshua, primary, O’Hartaigh, Briain, additional, Gransar, Heidi, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel, additional, Budoff, Matthew, additional, Cademartiri, Filippo, additional, Callister, Tracy, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Cury, Ricardo, additional, DeLago, Augustin, additional, Dunning, Allison, additional, Feuchtner, Gudrun, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kim, Yong-Jim, additional, Kaufmann, Philipp, additional, Leipsic, Jonathan, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Shaw, Leslee, additional, Villines, Todd, additional, and Min, James, additional

Published
2015
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158. DIURETIC RESPONSE IN ACUTE HEART FAILURE: AN ANALYSIS FROM ASCEND-HF

Author

Ter Maaten, Jozine, primary, Dunning, Allison, additional, Valente, Mattia A.E., additional, Damman, Kevin, additional, Ezekowitz, Justin, additional, Califf, Robert, additional, Starling, Randall, additional, O’Connor, Christopher, additional, Schulte, Phillip, additional, Testani, Jeffrey, additional, Hernandez, Adrian, additional, Tang, Wai Hong, additional, and Voors, Adriaan, additional

Published
2015
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159. Effects of cardiac medications for patients with obstructive coronary artery disease by coronary computed tomographic angiography: Results from the multicenter CONFIRM registry

Author

Schulman-Marcus, Joshua, primary, Hartaigh, Bríain ó, additional, Giambrone, Ashley E., additional, Gransar, Heidi, additional, Valenti, Valentina, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Cury, Ricardo, additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Kaufmann, Philipp A., additional, Leipsic, Jonathon, additional, Lin, Fay Y., additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Shaw, Leslee J., additional, Villines, Todd C., additional, Dunning, Allison, additional, and Min, James K., additional

Published
2015
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160. Age-related risk of major adverse cardiac event risk and coronary artery disease extent and severity by coronary CT angiography: results from 15 187 patients from the International Multisite CONFIRM Study.

Author

Nakazato, Ryo, Nakazato, Ryo, Arsanjani, Reza, Achenbach, Stephan, Gransar, Heidi, Cheng, Victor Y, Dunning, Allison, Lin, Fay Y, Al-Mallah, Mouaz, Budoff, Matthew J, Callister, Tracy Q, Chang, Hyuk-Jae, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Raff, Gilbert, Shaw, Leslee J, Villines, Todd, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Berman, Daniel S, Min, James K, Nakazato, Ryo, Nakazato, Ryo, Arsanjani, Reza, Achenbach, Stephan, Gransar, Heidi, Cheng, Victor Y, Dunning, Allison, Lin, Fay Y, Al-Mallah, Mouaz, Budoff, Matthew J, Callister, Tracy Q, Chang, Hyuk-Jae, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Raff, Gilbert, Shaw, Leslee J, Villines, Todd, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Berman, Daniel S, and Min, James K

Abstract

AimsPrior studies evaluating the prognostic utility of cardiac CT angiography (CCTA) have been largely constrained to an all-cause mortality endpoint, with other cardiac endpoints generally not reported. To this end, we sought to determine the relationship of extent and severity of coronary artery disease (CAD) by CCTA to risk of incident major adverse cardiac events (MACEs) (defined as death, myocardial infarction, and late revascularization).Methods and resultsWe identified subjects without prior known CAD who underwent CCTA and were followed for MACE. CAD by CCTA was defined as none (0% luminal stenosis), mild (1-49% luminal stenosis), moderate (50-69% luminal stenosis), or severe (≥70% luminal stenosis), and ≥50% luminal stenosis was considered as obstructive. CAD severity was judged on per-patient, per-vessel, and per-segment basis. Time to MACE was estimated using univariable and multivariable Cox proportional hazards models. Among 15 187 patients (57 ± 12 years, 55% male), 595 MACE events (3.9%) occurred at a 2.4 ± 1.2 year follow-up. In multivariable analyses, an increased risk of MACE was observed for both non-obstructive [hazard ratio (HR) 2.43, P < 0.001] and obstructive CAD (HR: 11.21, P < 0.001) when compared with patients with normal CCTA. Risk-adjusted MACE increased in a dose-response relationship based on the number of vessels with obstructive CAD ≥50%, with increasing hazards observed for non-obstructive (HR: 2.54, P < 0.001), obstructive one-vessel (HR: 9.15, P < 0.001), two-vessel (HR: 15.00, P < 0.001), or three-vessel or left main (HR: 24.53, P < 0.001) CAD. Among patients stratified by age <65 vs. ≥65 years, older individuals experienced higher risk-adjusted hazards for MACE for non-obstructive, one-, and two-vessel, with similar event rates for three-vessel or left main (P < 0.001 for all) compared with normal individuals age <65. Finally, there was a dose relationship of CAD findings by CCTA and MACE event rates wi

Published
2014

161. Incremental prognostic value of coronary computed tomographic angiography over coronary artery calcium score for risk prediction of major adverse cardiac events in asymptomatic diabetic individuals.

Author

Min, James K, Min, James K, Labounty, Troy M, Gomez, Millie J, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M, Chow, Benjamin, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jorg, Kaufmann, Philipp, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, Berman, Daniel S, Min, James K, Min, James K, Labounty, Troy M, Gomez, Millie J, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M, Chow, Benjamin, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jorg, Kaufmann, Philipp, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, and Berman, Daniel S

Abstract

BackgroundCoronary artery disease (CAD) diagnosis by coronary computed tomographic angiography (CCTA) is useful for identification of symptomatic diabetic individuals at heightened risk for death. Whether CCTA-detected CAD enables improved risk assessment of asymptomatic diabetic individuals beyond clinical risk factors and coronary artery calcium scoring (CACS) remains unexplored.MethodsFrom a prospective 12-center international registry of 27,125 individuals undergoing CCTA, we identified 400 asymptomatic diabetic individuals without known CAD. Coronary stenosis by CCTA was graded as 0%, 1-49%, 50-69%, and ≥70%. CAD was judged on a per-patient, per-vessel and per-segment basis as maximal stenosis severity, number of vessels with ≥50% stenosis, and coronary segments weighted for stenosis severity (segment stenosis score), respectively. We assessed major adverse cardiovascular events (MACE) - inclusive of mortality, nonfatal myocardial infarction (MI), and late target vessel revascularization ≥90 days (REV) - and evaluated the incremental utility of CCTA for risk prediction, discrimination and reclassification.ResultsMean age was 60.4 ± 9.9 years; 65.0% were male. At a mean follow-up 2.4 ± 1.1 years, 33 MACE occurred (13 deaths, 8 MI, 12 REV) [8.25%; annualized rate 3.4%]. By univariate analysis, per-patient maximal stenosis [hazards ratio (HR) 2.24 per stenosis grade, 95% confidence interval (CI) 1.61-3.10, p < 0.001], increasing numbers of obstructive vessels (HR 2.30 per vessel, 95% CI 1.75-3.03, p < 0.001) and segment stenosis score (HR 1.14 per segment, 95% CI 1.09-1.19, p < 0.001) were associated with increased MACE. After adjustment for CAD risk factors and CACS, maximal stenosis (HR 1.80 per grade, 95% CI 1.18-2.75, p = 0.006), number of obstructive vessels (HR 1.85 per vessel, 95% CI 1.29-2.65, p < 0.001) and segment stenosis score (HR 1.11 per segment, 95% CI 1.05-1.18, p < 0.001) were associated with increased risk of MACE. Beyond age, gend

Published
2014

162. Sex-based prognostic implications of nonobstructive coronary artery disease: results from the international multicenter CONFIRM study.

Author

Leipsic, Jonathon, Leipsic, Jonathon, Taylor, Carolyn M, Gransar, Heidi, Shaw, Leslee J, Ahmadi, Amir, Thompson, Angus, Humphries, Karin, Berman, Daniel S, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, Min, James K, Leipsic, Jonathon, Leipsic, Jonathon, Taylor, Carolyn M, Gransar, Heidi, Shaw, Leslee J, Ahmadi, Amir, Thompson, Angus, Humphries, Karin, Berman, Daniel S, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, and Min, James K

Abstract

PurposeTo determine the clinical outcomes of women and men with nonobstructive coronary artery disease ( CAD coronary artery disease ) with coronary computed tomographic (CT) angiography data in patients who were similar in terms of CAD coronary artery disease risk factors, angina typicality, and CAD coronary artery disease extent and distribution.Materials and methodsInstitutional review board approval was obtained for all participating sites, with either informed consent or waiver of informed consent. In a prospective international multicenter cohort study of 27 125 patients undergoing coronary CT angiography at 12 centers, 18 158 patients with no CAD coronary artery disease or nonobstructive (<50% stenosis) CAD coronary artery disease were examined. Men and women were propensity matched for age, CAD coronary artery disease risk factors, angina typicality, and CAD coronary artery disease extent and distribution, which resulted in a final cohort of 11 462 subjects. Nonobstructive CAD coronary artery disease presence and extent were related to incident major adverse cardiovascular events ( MACE major adverse cardiovascular events ), which were inclusive of death and myocardial infarction and were estimated by using multivariable Cox proportional hazards models.ResultsAt a mean follow-up ± standard deviation of 2.3 years ± 1.1, MACE major adverse cardiovascular events occurred in 164 patients (0.6% annual event rate). After matching, women and men experienced identical annualized rates of myocardial infarction (0.2% vs 0.2%, P = .72), death (0.5% vs 0.5%, P = .98), and MACE major adverse cardiovascular events (0.6% vs 0.6%, P = .94). In multivariable analysis, nonobstructive CAD coronary artery disease was associated with similarly increased MACE major adverse cardiovascular events for both women (hazard ratio: 1.96 [95% confidence interval { CI confidence interval }: 1.17, 3.28], P = .01) and men (hazard ratio: 1.77 [95% CI confidence interval : 1.07, 2.93], P =

Published
2014

163. Prognostic significance of calcified plaque among symptomatic patients with nonobstructive coronary artery disease.

Author

Shah, Sana, Shah, Sana, Bellam, Naveen, Leipsic, Jonathon, Berman, Daniel S, Quyyumi, Arshed, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Karlsberg, Ronald P, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, Min, James K, Shaw, Leslee J, CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) Investigators, Shah, Sana, Shah, Sana, Bellam, Naveen, Leipsic, Jonathon, Berman, Daniel S, Quyyumi, Arshed, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Karlsberg, Ronald P, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, Min, James K, Shaw, Leslee J, and CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) Investigators

Abstract

BackgroundCoronary artery calcium (CAC) is a well-established predictor of clinical outcomes for population screening. Limited evidence is available as to its predictive value in symptomatic patients without obstructive coronary artery disease (CAD). The aim of the current study was to assess the prognostic value of CAC scores among symptomatic patients with nonobstructive CAD.MethodsFrom the COronary Computed Tomographic Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 7,200 symptomatic patients with nonobstructive CAD (<50% coronary stenosis) on coronary-computed tomographic angiography were prospectively enrolled and followed for a median of 2.1 years. Patients were categorized as without (0% stenosis) or with (>0% but <50% coronary stenosis) a luminal stenosis. CAC scores were calculated using the Agatston method. Univariable and multivariable Cox proportional hazard models were employed to estimate all-cause mortality and/or myocardial infarction (MI). Four-year death and death or MI rates were 1.9% and 3.3%.ResultsOf the 4,380 patients with no luminal stenosis, 86% had CAC scores of <10 while those with a luminal stenosis had more prevalent and extensive CAC with 31.9% having a CAC score of ≥100. Among patients with no luminal stenosis, CAC was not predictive of all-cause mortality (P = .44). However, among patients with a luminal stenosis, 4-year mortality rates ranged from 0.8% to 9.8% for CAC scores of 0 to ≥400 (P < .0001). The mortality hazard was 6.0 (P = .004) and 13.3 (P < .0001) for patients with a CAC score of 100-399 and ≥400. In patients with a luminal stenosis, CAC remained independently predictive in all-cause mortality (P < .0001) and death or MI (P < .0001) in multivariable models containing CAD risk factors and presenting symptoms.ConclusionsCAC allows for the identification of those at an increased hazard for death or MI in symptomatic patients with nonobstructive disease.

Published
2014

165. Relationship of Hypertension to Coronary Atherosclerosis and Cardiac Events in Patients With Coronary Computed Tomographic Angiography.

Author

Budoff, Matthew J., Nakanishi, Rine, Chinnaiyan, Kavitha, Raff, Gilbert, Chow, Benjamin J. W., DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Cury, Ricardo, Feuchtner, Gudrun, Yong-Jin Kim, Leipsic, Jonathon, Kaufmann, Philipp A., Gransar, Heidi, Berman, Daniel S., Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Marques, Hugo, and Pontone, Gianluca

Abstract

Hypertension is an atherosclerosis factor and is associated with cardiovascular risk. We investigated the relationship between hypertension and the presence, extent, and severity of coronary atherosclerosis in coronary computed tomographic angiography and cardiac events risk. Of 17 181 patients enrolled in the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) who underwent ≥64-detector row coronary computed tomographic angiography, we identified 14 803 patients without known coronary artery disease. Of these, 1434 hypertensive patients were matched to 1434 patients without hypertension. Major adverse cardiac events risk of hypertension and non-hypertensive patients was evaluated with Cox proportional hazards models. The prognostic associations between hypertension and no-hypertension with increasing degree of coronary stenosis severity (nonobstructive or obstructive ≥50%) and extent of coronary artery disease (segment involvement score of 1-5, >5) was also assessed. Hypertension patients less commonly had no coronary atherosclerosis and more commonly had nonobstructive and 1-, 2-, and 3-vessel disease than the no-hypertension group. During a mean follow-up of 5.2±1.2 years, 180 patients experienced cardiac events, with 104 (2.0%) occurring in the hypertension group and 76 (1.5%) occurring in the no-hypertension group (hazard ratios, 1.4; 95% confidence intervals, 1.0-1.9). Compared with no-hypertension patients without coronary atherosclerosis, hypertension patients with no coronary atherosclerosis and obstructive coronary disease tended to have higher risk of cardiac events. Similar trends were observed with respect to extent of coronary artery disease. Compared with no-hypertension patients, hypertensive patients have increased presence, extent, and severity of coronary atherosclerosis and tend to have an increase in major adverse cardiac events. [ABSTRACT FROM AUTHOR]

Published
2017
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166. Predictive Value of Age- and Sex-Specific Nomograms of Global Plaque Burden on Coronary Computed Tomography Angiography for Major Cardiac Events.

Author

Naoum, Christopher, Berman, Daniel S., Ahmadi, Amir, Blanke, Philipp, Gransar, Heidi, Narula, Jagat, Shaw, Leslee J., Kritharides, Leonard, Achenbach, Stephan, Al-Mallah, Mouaz H., Andreini, Daniele, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Hyuk-Jae Chang, Chinnaiyan, Kavitha, Chow, Benjamin, Cury, Ricardo C., DeLago, Augustin, and Dunning, Allison

Abstract

Background--Age-adjusted coronary artery disease (CAD) burden identified on coronary computed tomography angiography predicts major adverse cardiovascular event (MACE) risk; however, it seldom contributes to clinical decision making because of a lack of nomographic data. We aimed to develop clinically pragmatic age- and sex-specific nomograms of CAD burden using coronary computed tomography angiography and to validate their prognostic use. Methods and Results--Patients prospectively enrolled in phase I of the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes) were included (derivation cohort: n=21,132; 46% female) to develop CAD nomograms based on age-sex percentiles of segment involvement score (SIS) at each year of life (40-79 years). The relationship between SIS age-sex percentiles (SIS%) and MACE (all-cause death, myocardial infarction, unstable angina, and late revascularization) was tested in a nonoverlapping validation cohort (phase II, CONFIRM registry; n=3030, 44% female) by stratifying patients into 3 SIS% groups (≤50th, 51-75th, and >75th) and comparing annualized MACE rates and time to MACE using multivariable Cox proportional hazards models adjusting for Framingham risk and chest pain typicality. Age-sex percentiles were well fitted to second-order polynomial curves (men: R2=0.86±0.12; women: R2=0.86±0.14). Using the nomograms, there were 1576, 965, and 489 patients, respectively, in the ≤50th, 51-75th, and >75th SIS% groups. Annualized event rates were higher among patients with greater CAD burden (2.1% [95% confidence interval: 1.7%-2.7%], 3.9% [95% confidence interval: 3.0%-5.1%], and 7.2% [95% confidence interval: 5.4%-9.6%] in ≤50th, 51-75th, and >75th SIS% groups, respectively; P<0.001). Adjusted MACE risk was significantly increased among patients in SIS% groups above the median compared with patients below the median (hazard ratio [95% confidence interval]: 1.9 [1.3-2.8] for 51-75th SIS% group and 3.4 [2.3-5.0] for >75th SIS% group; P<0.01 for both). Conclusions--We have developed clinically pragmatic age- and sex-specific nomograms of CAD prevalence using coronary computed tomography angiography findings. Global plaque burden measured using SIS% is predictive of cardiac events independent of traditional risk assessment. [ABSTRACT FROM AUTHOR]

Published
2017
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167. Improved 5-year prediction of all-cause mortality by coronary CT angiography applying the CONFIRM score.

Author

Deseive, Simon, Shaw, Leslee J., Min, James K., Achenbach, Stephan, Andreini, Daniele, Al-Mallah, Mouaz H., Berman, Daniel S., Budoff, Matthew J., Callister, Tracy Q., Cademartiri, Filippo, Hyuk-Jae Chang, Chinnaiyan, Kavitha, Chow, Benjamin J. W., Cury, Ricardo C., DeLago, Augustin, Dunning, Allison M., Feuchtner, Gudrun, Kaufmann, Philipp A., Yong-Jin Kim, and Leipsic, Jonathon

Subjects
ADENOSINE triphosphate, BLOOD vessels, COMPUTED tomography, CONFIDENCE intervals, MORTALITY, POPULATION, PREDICTIVE validity, DESCRIPTIVE statistics, CORONARY angiography
Abstract

Aims To investigate the long-term performance of the CONFIRM score for prediction of all-cause mortality in a large patient cohort undergoing coronary computed tomography angiography (CCTA). Methods and results Patients with a 5-year follow-up from the international multicentre CONFIRM registry were included. The primary endpoint was all-cause mortality. The predictive value of the CONFIRM score over clinical risk scores (Morise, Framingham, and NCEP ATP III score) was studied in the entire patient population as well as in subgroups. Improvement in risk prediction and patient reclassification were assessed using categorical net reclassification index (NRI) and integrated discrimination improvement (IDI). During a median follow-up period of 5.3 years, 982 (6.5%) of 15 219 patients died. The CONFIRM score outperformed the prognostic value of the studied three clinical risk scores (c-indices: CONFIRM score 0.696, NCEP ATP III score 0.675, Framingham score 0.610, Morise score 0.606; c-index for improvement CONFIRM score vs. NCEP ATP III score 0.650, P < 0.0001). Application of the CONFIRM score allowed reclassification of 34% of patients when compared with the NCEP ATP III score, which was the best clinical risk score. Reclassification was significant as revealed by categorical NRI (0.06 with 95% CI 0.02 and 0.10, P = 0.005) and IDI (0.013 with 95% CI 0.01 and 0.015, P < 0.001). Subgroup analysis revealed a comparable performance in a variety of patient subgroups. Conclusions The CONFIRM score permits a significantly improved prediction of mortality over clinical risk scores for >5 years after CCTA. These findings are consistent in a large variety of patient subgroups. [ABSTRACT FROM AUTHOR]

Published
2017
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169. Abstract 17557: Prevalence, Characteristics, and Early Treatment Strategies of Patients with Chronic Total Occlusions Undergoing Coronary Computed Tomography Angiography

Author

Opolski, Maksymilian P, primary, Hartaigh, Bríain Ó, additional, Gransar, Heidi, additional, Schulman-Marcus, Joshua, additional, Truong, Quynh A, additional, Berman, Daniel S, additional, Budoff, Matthew J, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J, additional, Cury, Ricardo, additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Kaufmann, Philipp A, additional, Leipsic, Jonathon, additional, Lin, Fay Y, additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Shaw, Leslee J, additional, Villines, Todd C, additional, Dunning, Allison, additional, and Min, James K, additional

Published
2014
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170. Abstract 12044: Absence of Coronary Artery Disease by Coronary Computed Tomographic Angiography and the Warranty Period Associated With All-Cause Mortality: Findings From the CONFIRM Long-Term Follow-Up Registry

Author

Cho, Iksung, primary, ó Hartaigh, Bríain, additional, Gransar, Heidi, additional, Schulman-Marcus, Joshua, additional, Valenti, Valentina, additional, Berman, Daniel S, additional, Budoff, Matthew J, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Cury, Ricardo, additional, Delago, Augustin, additional, Gomez, Millie, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Hindoyan, Niree, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Kaufmann, Philipp A, additional, Leipsic, Jonathon, additional, Lin, Fay Y, additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Shaw, Leslee J, additional, Villines, Todd C, additional, Dunning, Allison, additional, and Min, James K, additional

Published
2014
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171. Abstract 18816: Relationship of Aortic Valve Surgery and Survival in Patients with Moderate or Severe Aortic Stenosis and Left Ventricular Dysfunction

Author

Samad, Zainab, primary, Vora, Amit N, additional, Dunning, Allison, additional, Sivak, Joseph A, additional, Shaw, Linda K, additional, Vavalle, John P, additional, Sherwood, Matthew W, additional, Hofmann, Paul, additional, Glower, Donald D, additional, Kisslo, Joseph A, additional, Harrison, J. Kevin, additional, and Velazquez, Eric J, additional

Published
2014
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173. Sex-based Prognostic Implications of Nonobstructive Coronary Artery Disease: Results from the International Multicenter CONFIRM Study

Author

Leipsic, Jonathon, primary, Taylor, Carolyn M., additional, Gransar, Heidi, additional, Shaw, Leslee J., additional, Ahmadi, Amir, additional, Thompson, Angus, additional, Humphries, Karin, additional, Berman, Daniel S., additional, Hausleiter, Jörg, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Fillippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chow, Benjamin J. W., additional, Cury, Ricardo C., additional, Delago, Augustin J., additional, Dunning, Allison L., additional, Feuchtner, Gudrun M., additional, Hadamitzky, Martin, additional, Kaufmann, Philipp A., additional, Lin, Fay Y., additional, Chinnaiyan, Kavitha M., additional, Maffei, Erica, additional, Raff, Gilbert L., additional, Villines, Todd C., additional, Gomez, Millie J., additional, and Min, James K., additional

Published
2014
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174. Incremental prognostic utility of coronary CT angiography for asymptomatic patients based upon extent and severity of coronary artery calcium: results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) Study

Author

Cho, Iksung, primary, Chang, Hyuk-Jae, additional, Ó Hartaigh, Bríain, additional, Shin, Sanghoon, additional, Sung, Ji Min, additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Heo, Ran, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Callister, Tracy Q., additional, Al-Mallah, Mouaz H., additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Dunning, Allison M., additional, DeLago, Augustin, additional, Villines, Todd C., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Leipsic, Jonathon, additional, Shaw, Leslee J., additional, Kaufmann, Philipp A., additional, Cury, Ricardo C., additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, and Min, James K., additional

Published
2014
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178. Response to Letter Regarding Article, “Noninvasive Fractional Flow Reserve Derived From Computed Tomography Angiography for Coronary Lesions of Intermediate Stenosis Severity: Results From the DeFACTO Study”

Author

Nakazato, Ryo, primary, Park, Hyung-Bok, additional, Berman, Daniel S., additional, Gransar, Heidi, additional, Koo, Bon-Kwon, additional, Erglis, Andrejs, additional, Lin, Fay Y., additional, Dunning, Allison M., additional, Budoff, Matthew J., additional, Malpeso, Jennifer, additional, Leipsic, Jonathon, additional, and Min, James K., additional

Published
2014
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179. Incremental prognostic value of coronary computed tomographic angiography over coronary artery calcium score for risk prediction of major adverse cardiac events in asymptomatic diabetic individuals

Author

Min, James K., primary, Labounty, Troy M., additional, Gomez, Millie J., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cheng, Victor, additional, Chinnaiyan, Kavitha M., additional, Chow, Benjamin, additional, Cury, Ricardo, additional, Delago, Augustin, additional, Dunning, Allison, additional, Feuchtner, Gudrun, additional, Hadamitzky, Martin, additional, Hausleiter, Jorg, additional, Kaufmann, Philipp, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, Lin, Fay Y., additional, Maffei, Erica, additional, Raff, Gilbert, additional, Shaw, Leslee J., additional, Villines, Todd C., additional, and Berman, Daniel S., additional

Published
2014
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181. Optimized prognostic score for coronary computed tomographic angiography results from the confirm registry (COronary CT Angiography EvaluatioNFor Clinical Outcomes: An InteRnational Multicenter Registry)

Author

Hadamitzky, Martin, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel, Budoff, Matthew, Cademartiri, Filippo, Callister, Tracy, Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha, Chow, Benjamin J W, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Gomez, Millie, Kaufmann, Philipp, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Min, James K, Raff, Gil, Shaw, Leslee J, Villines, Todd C, Hausleiter, Jörg, Hadamitzky, Martin, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel, Budoff, Matthew, Cademartiri, Filippo, Callister, Tracy, Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha, Chow, Benjamin J W, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Gomez, Millie, Kaufmann, Philipp, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Min, James K, Raff, Gil, Shaw, Leslee J, Villines, Todd C, and Hausleiter, Jörg

Abstract

OBJECTIVE: to analyze the predictive value of coronary CT angiography and to model and validate an optimized score for prognosis of 2-year survival based on a patient population with suspected coronary artery disease (CAD). BACKGROUND: Coronary CT angiography (CCTA) carries important prognostic information in addition to the detection of obstructive coronary artery disease. But it is still unclear how the results of CCTA should be interpreted in the context of clinical risk predictors METHODS: The analysis is based on a test sample of 17,793 patients and a validation sample of 2,506 patients, all with suspected CAD, from the international CONFIRM registry. Based on CCTA data and clinical risk scores, an optimized score was modeled. The endpoint was all cause mortality. RESULTS: During a median follow-up of 2.3 years, 347 patients died. Best CCTA parameter for prediction of mortality was the number of proximal segments with mixed or calcified plaques (C-index 0.64, p<0.0001) and the number of proximal segments with a stenosis >50% (C-index 0.56, p=0.002). In an optimized score including both parameters, CCTA significantly improved overall risk prediction beyond NCEP ATP III score as best clinical score. According to this score, a proximal segment with either a mixed or calcified plaque or a stenosis >50% is equivalent to a 5 year increase in age or the risk of smoking. CONCLUSION: In CCTA, both plaque burden and stenosis, particularly in proximal segments, carry incremental prognostic value. A prognostic score based on this data can improve risk prediction beyond clinical risk scores.

Published
2013

182. Transcatheter Aortic Valve Replacement versus Medical Management among Patients with Aortic Stenosis and Left Ventricular Systolic Dysfunction

Author

Lowenstern, Angela, Vora, Amit N., Dunning, Allison, Schulte, Phillip J., Vemulapalli, Sreekanth, Hughes, G. Chad, Velazquez, Eric J., Harrison, J. Kevin, and Samad, Zainab

Abstract

ABSTRACTBackground: There is limited evidence regarding outcomes of patients with severe aortic stenosis (AS) and concomitant left ventricular systolic dysfunction (LVSD). We evaluated mortality in patients with severe AS and LVSD undergoing transcatheter aortic valve replacement (TAVR) compared with a matched medically managed cohort.Methods: We studied 206 patients who underwent TAVR at Duke University and had a transthoracic echocardiogram within 6 months prior to the procedure and a matched medically managed historical cohort (n = 206). All TAVR patients were matched 1:1 by AS resting mean gradient and/or peak velocity, age, left ventricular ejection fraction (LVEF) and EuroSCORE. We used Cox multivariable modeling to assess the relationship between TAVR and all-cause mortality. Two survival analyses were completed to evaluate mortality—first in patients with LVEF≤ 35% and then with LVEF≤ 35% versus 36–50%.Results: The median age of patients was 82 (IQR 76–86). Patients who underwent TAVR were more likely to be male, have a history of ischemic heart disease, renal insufficiency, heart failure and coronary artery bypass graft (CABG) (all p < 0.05). TAVR was associated with mortality reduction compared with medical management (HR 0.31, 95%CI 0.21–0.45, p < 0.0001), which persisted after multivariable adjustment (HR 0.26, 95%CI 0.18–0.39, p < 0.0001). After adjustment, TAVR provided a larger estimated decrease in mortality risk in patients with LVEF> 35% (HR 0.23, 95%CI 0.15–0.35), than in patients with LVEF≤ 35% (HR 0.60, 95%CI 0.23–1.52, p-interaction = 0.0605).Conclusion: Compared with medical management, TAVR is associated with longer survival in all patients, including those with LVSD. TAVR should be explored further as a therapeutic option in this patient population.

Published
2018
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183. Noninvasive Fractional Flow Reserve Derived From Computed Tomography Angiography for Coronary Lesions of Intermediate Stenosis Severity

Author

Nakazato, Ryo, primary, Park, Hyung-Bok, additional, Berman, Daniel S., additional, Gransar, Heidi, additional, Koo, Bon-Kwon, additional, Erglis, Andrejs, additional, Lin, Fay Y., additional, Dunning, Allison M., additional, Budoff, Matthew J., additional, Malpeso, Jennifer, additional, Leipsic, Jonathon, additional, and Min, James K., additional

Published
2013
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184. Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.

Author

Guo, Yan, Warren Andersen, Shaneda, Shu, Xiao-Ou, Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Garcia-Closas, Montserrat, Milne, Roger L., Schmidt, Marjanka K., Chang-Claude, Jenny, Dunning, Allison, Bojesen, Stig E., Ahsan, Habibul, Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, and Benitez, Javier

Subjects
BODY mass index, BREAST cancer risk factors, BREAST cancer diagnosis, PERIMENOPAUSE, MEDICAL genetics
Abstract

Background: Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.Methods: We applied Mendelian randomization to evaluate the association between BMI and risk of breast cancer occurrence using data from two large breast cancer consortia. We created a weighted BMI genetic score comprising 84 BMI-associated genetic variants to predicted BMI. We evaluated genetically predicted BMI in association with breast cancer risk using individual-level data from the Breast Cancer Association Consortium (BCAC) (cases  =  46,325, controls  =  42,482). We further evaluated the association between genetically predicted BMI and breast cancer risk using summary statistics from 16,003 cases and 41,335 controls from the Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Project. Because most studies measured BMI after cancer diagnosis, we could not conduct a parallel analysis to adequately evaluate the association of measured BMI with breast cancer risk prospectively.Results: In the BCAC data, genetically predicted BMI was found to be inversely associated with breast cancer risk (odds ratio [OR]  =  0.65 per 5 kg/m2 increase, 95% confidence interval [CI]: 0.56-0.75, p = 3.32 × 10-10). The associations were similar for both premenopausal (OR   =   0.44, 95% CI:0.31-0.62, p  =  9.91 × 10-8) and postmenopausal breast cancer (OR  =  0.57, 95% CI: 0.46-0.71, p  =  1.88 × 10-8). This association was replicated in the data from the DRIVE consortium (OR  =  0.72, 95% CI: 0.60-0.84, p   =   1.64 × 10-7). Single marker analyses identified 17 of the 84 BMI-associated single nucleotide polymorphisms (SNPs) in association with breast cancer risk at p < 0.05; for 16 of them, the allele associated with elevated BMI was associated with reduced breast cancer risk.Conclusions: BMI predicted by genome-wide association studies (GWAS)-identified variants is inversely associated with the risk of both pre- and postmenopausal breast cancer. The reduced risk of postmenopausal breast cancer associated with genetically predicted BMI observed in this study differs from the positive association reported from studies using measured adult BMI. Understanding the reasons for this discrepancy may reveal insights into the complex relationship of genetic determinants of body weight in the etiology of breast cancer. [ABSTRACT FROM AUTHOR]

Published
2016
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185. Abstract 18267: Coronary Risk Factors and Prevalence and Severity of Coronary Atherosclerosis in the Young

Author

Otaki, Yuka, primary, Gransar, Heidi, additional, Dey, Damini, additional, Lin, Fay, additional, Cheng, Victor, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Matthew, Budoff, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin, additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hauesleiter, Joerg, additional, Kaufmann, Philippo, additional, Maeffei, Erica, additional, Shaw, LesLee, additional, Berman, Daniel, additional, Feuchtner, Gurdun, additional, Dunning, Allison, additional, Villines, Todd, additional, and Min, James K, additional

Published
2012
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186. Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry

Author

Nakazato, Ryo, primary, Gransar, Heidi, additional, Berman, Daniel S., additional, Cheng, Victor Y., additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cury, Ricardo C., additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Shaw, Leslee J., additional, Villines, Todd C., additional, Dunning, Allison, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, and Min, James K., additional

Published
2012
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187. Coronary Computed Tomographic Angiography as a Gatekeeper to Invasive Diagnostic and Surgical Procedures

Author

Shaw, Leslee J., primary, Hausleiter, Jörg, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Fillippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Kim, Yong-Jin, additional, Cheng, Victor Y., additional, Chow, Benjamin J.W., additional, Cury, Ricardo C., additional, Delago, Augustin J., additional, Dunning, Allison L., additional, Feuchtner, Gudrun M., additional, Hadamitzky, Martin, additional, Karlsberg, Ronald P., additional, Kaufmann, Philipp A., additional, Leipsic, Jonathon, additional, Lin, Fay Y., additional, Chinnaiyan, Kavitha M., additional, Maffei, Erica, additional, Raff, Gilbert L., additional, Villines, Todd C., additional, LaBounty, Troy, additional, Gomez, Millie J., additional, and Min, James K., additional

Published
2012
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188. Disease-free survival as a surrogate for overall survival in upper tract urothelial carcinoma

Author

Fajkovic, Harun, primary, Cha, Eugene K., additional, Xylinas, Evanguelos, additional, Rink, Michael, additional, Pycha, Armin, additional, Seitz, Christian, additional, Bolenz, Christian, additional, Dunning, Allison, additional, Novara, Giacomo, additional, Trinh, Quoc-Dien, additional, Karakiewicz, Pierre I., additional, Margulis, Vitaly, additional, Raman, Jay D., additional, Walton, Thomas J., additional, Baba, Shiro, additional, Carballido, Joaquin, additional, Otto, Wolfgang, additional, Montorsi, Francesco, additional, Lotan, Yair, additional, Kassouf, Wassim, additional, Fritsche, Hans-Martin, additional, Bensalah, Karim, additional, Zigeuner, Richard, additional, Scherr, Douglas S., additional, Sonpavde, Guru, additional, Roupret, Morgan, additional, and Shariat, Shahrokh F., additional

Published
2012
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189. Coronary Computed Tomographic Angiography and Risk of All-Cause Mortality and Nonfatal Myocardial Infarction in Subjects Without Chest Pain Syndrome From the CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry)

Author

Cho, Iksung, primary, Chang, Hyuk-Jae, additional, Sung, Ji Min, additional, Pencina, Michael J., additional, Lin, Fay Y., additional, Dunning, Allison M., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Callister, Tracy Q., additional, Chow, Benjamin J.W., additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Maffei, Erica, additional, Cademartiri, Filippo, additional, Kaufmann, Philipp, additional, Shaw, Leslee J., additional, Raff, Gil L., additional, Chinnaiyan, Kavitha M., additional, Villines, Todd C., additional, Cheng, Victor, additional, Nasir, Khurram, additional, Gomez, Millie, additional, and Min, James K., additional

Published
2012
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192. 392 DISEASE-FREE SURVIVAL AS A SURROGATE FOR 5-YEAR OVERALL SURVIVAL IN UPPER TRACT UROTHELIAL CARCINOMA

Author

Cha, Eugene K., primary, Fajkovic, Harun, additional, Rink, Michael, additional, Pycha, Armin, additional, Dunning, Allison, additional, Novara, Giacomo, additional, Karakiewicz, Pierre I., additional, Margulis, Vitaly, additional, Raman, Jay D., additional, Lotan, Yair, additional, Kassouf, Wassim, additional, Fritsche, Hans-Martin, additional, Bensalah, Karim, additional, Weizer, Alon, additional, Kikuchi, Eiji, additional, Roscigno, Marco, additional, Remzi, Mesut, additional, Matsumoto, Kazumasa, additional, Zigeuner, Richard, additional, Scherr, Douglas S., additional, Mazumdar, Madhu, additional, Sonpavde, Guru, additional, and Shariat, Shahrokh F., additional

Published
2012
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193. DEGREE OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION BY CARDIAC COMPUTED TOMOGRAPHIC ANGIOGRAPHY IMPROVES RISK STRATIFICATION AND DISCRIMINATION OF PATIENTS AT RISK FOR INCIDENT MORTALITY: RESULTS FROM 7907 PATIENTS IN THE PROSPECTIVE MULTICENTER INTERNATIONAL CONFIRM STUDY

Author

Arsanjani, Reza, primary, LaBounty, Troy, additional, Gransar, Heidi, additional, Cheng, Victor, additional, Dunning, Allison, additional, Lin, Fay, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew, additional, Cademartiri, Filippo, additional, Callister, Tracy, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin, additional, DeLago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Raff, Gilbert, additional, Shaw, Leslee, additional, Villines, Todd, additional, Berman, Daniel, additional, and Min, James, additional

Published
2012
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194. RELATIONSHIP BETWEEN LOW-AND HIGH-DENSITY LIPOPROTEINS AND CORONARY PLAQUE COMPOSITION: RESULTS FROM CONFIRM (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY)

Author

Nakazato, Ryo, primary, Berman, Daniel, additional, Achenbach, Stephan, additional, AI-Mallah, Mouaz, additional, Budoff, Matthew, additional, Cademartiri, Filippo, additional, Callister, Tracy, additional, Cheng, Victor, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin, additional, DeLago, Augustin, additional, Dunning, Allison, additional, feuchtner, gudrun, additional, Gomez, Millie, additional, Gransar, Heidi, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Lin, Fay, additional, Raff, Gilbert, additional, Shaw, Leslee, additional, Villines, Todd, additional, LaBounty, Troy, additional, and Min, James, additional

Published
2012
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195. DOES NONCALCIFIED PLAQUE IMPROVE THE DIAGNOSTIC AND PROGNOSTIC UTILITY OF CORONARY CT ANGIOGRAPHY? A STUDY OF PROPENSITY-MATCHED INDIVIDUALS WITH SIMILAR CORONARY CALCIUM SCORES FROM THE PROSPECTIVE MULTICENTER INTERNATIONAL CONFIRM REGISTRY

Author

Nakanishi, Rine, primary, Gransar, Heidi, additional, Berman, Daniel S., additional, Cheng, Victor, additional, Dey, Damini, additional, LaBounty, Troy, additional, Lin, Fay, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Raff, Gilbert, additional, Villines, Todd, additional, Shaw, Leslee J., additional, Dunning, Allison, additional, and Min, James K., additional

Published
2012
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196. DIFFERENTIAL IMPACT OF TRADITIONAL RISK FACTORS FOR PREDICTING THE PROBABILITY OF OBSTRUCTIVE CORONARY ARTERY DISEASE IN MEN AND WOMEN WITH CHEST PAIN: RESULTS FROM THE MULTINATIONAL CONFIRM REGISTRY

Author

Cheng, Victor Y., primary, Berman, Daniel, additional, Dunning, Allison, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew, additional, Cademartiri, Filippo, additional, Callister, Tracy, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin, additional, DeLago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, LaBounty, Troy, additional, Lin, Fay, additional, Raff, Gilbert, additional, Shaw, Leslee, additional, Villines, Todd, additional, and Min, James, additional

Published
2012
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197. ASYMPTOMATIC INDIVIDUALS WITH NON-CALCIFIED PLAQUE ALONE BY CORONARY CT ANGIOGRAPHY: ASSOCIATION TO CORONARY ARTERY DISEASE RISK FACTORS AND PROGNOSTIC IMPLICATIONS FOR PATIENTS IN THE PROSPECTIVE MULTICENTER INTERNATIONAL CONFIRM REGISTRY

Author

Achenbach, Stephan, primary, Dunning, Allison, additional, Berman, Daniel, additional, Budoff, Matthew, additional, Callister, Tracy, additional, Chang, Hyuk-Jae, additional, Cheng, Victor, additional, DeLago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Karlsberg, Ronald, additional, Kaufmann, Philipp, additional, Lin, Fay, additional, Al-Mallah, Mouaz, additional, Nasir, Khurram, additional, Shaw, Leslee, additional, Villines, Todd, additional, and Min, James, additional

Published
2012
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198. YOUNG PATIENTS WITH A FAMILY HISTORY OF CORONARY ARTERY DISEASE HAVE HIGHER PREVALENCE, INCREASED SEVERITY, AND WORSE PROGNOSIS OF CORONARY ATHEROSCLEROSIS: RESULTS FROM 6308 PATIENTS IN THE PROSPECTIVE MULTINATIONAL CONFIRM REGISTRY (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY)

Author

Otaki, Yuka, primary, LaBounty, Troy, additional, Dunning, Allison, additional, Gransar, Heidi, additional, Lin, Fay, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew, additional, Cademartiri, Filippo, additional, Cheng, Victor, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, DeLago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Raff, Gilbert, additional, Shaw, Leslee, additional, Villines, Todd, additional, Berman, Daniel, additional, and Min, James, additional

Published
2012
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199. EFFECT OF STATINS ON CORONARY ARTERY PLAQUE COMPOSITION: RESULTS FROM CONFIRM (CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY)

Author

Nakazato, Ryo, primary, Berman, Daniel, additional, Achenbach, Stephan, additional, AI-Mallah, Mouaz, additional, Budoff, Matthew, additional, Cademartiri, Filippo, additional, Callister, Tracy, additional, Cheng, Victor, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin, additional, DeLago, Augustin, additional, Dunning, Allison, additional, feuchtner, gudrun, additional, Gomez, Millie, additional, Gransar, Heidi, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Lin, Fay, additional, Raff, Gilbert, additional, Shaw, Leslee, additional, Villines, Todd, additional, LaBounty, Troy, additional, and Min, James, additional

Published
2012
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200. CARDIOLOGIST CONCORDANCE WITH THE AMERICAN COLLEGE OF CARDIOLOGY APPROPRIATE USE CRITERIA FOR CARDIAC TESTING IN CORONARY ARTERY DISEASE: RESULTS FROM A MULTIMODALITY CASE-BASED SURVEY

Author

Lin, Fay, primary, Rosenbaum, Lisa R., additional, Gebow, Dan, additional, Kim, Robert, additional, Wolk, Michael, additional, Patel, Manesh, additional, Dunning, Allison M., additional, LaBounty, Troy, additional, Gomez, Millie, additional, Shaw, Leslee, additional, Narula, Jagat, additional, Douglas, Pamela, additional, Raman, Subha, additional, Berman, Daniel, additional, and Min, James, additional

Published
2012
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