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low tide sees the water peel back revealing the low slung curve of stones as if the sea gods had slung them there waiting for receding wash to show them [...]

Objective: The aim of this study was to compare the incidence of airway haemorrhage between participants who received manual cardiopulmonary resuscitation (CPR) and those who had received mechanical CPR using the LUCAS device.Methods: A retrospective cohort study was conducted by means of a medical chart review. All non-traumatic cardiac arrest patients that presented to the ED, from May 2014 to February 2018, were recruited. The groups were stratified according to those who had the majority of CPR performed using the LUCAS and those who had the majority of CPR performed manually. The primary outcome was the proportion of participants with airway haemorrhage, defined as blood observed in the endotracheal tube, pharynx, trachea or mouth, and documented in the doctor or nursing notes. Logistic regression analysis was performed to adjust for confounders.Results: 12 of 54 (22%) participants in the majority LUCAS CPR group had airway haemorrhage, compared with 20 of 215 (9%) participants in the majority manual CPR group, a difference of 13% (95% CI 3% to 26%, p=0.02). The unadjusted odds for developing airway haemorrhage in the majority LUCAS CPR group was 2.8 (95% CI 1.3 to 6.1). After adjusting for confounders, the odds for developing airway haemorrhage in the majority LUCAS CPR group was 2.5 (95% CI 1.1 to 5.7).Conclusions: The LUCAS mechanical CPR device is associated with a higher incidence of airway haemorrhage compared with manual CPR. Limitations in the study design mean this conclusion is not robust. [ABSTRACT FROM AUTHOR]

Background: A measles outbreak occurred in age-appropriately vaccinated children in a school in a town in the South East of Ireland in September-November 2013.Aims: The purpose of this study was to investigate the risk factors associated with catching measles during the outbreak.Methods: Ninety-five children (4-5 years) in three classes, in the first year of primary school, were included in the study. Immunisation records on the South East Child Health Information System for first Measles Mumps and Rubella (MMR) vaccine for the 95 children were reviewed. Data collected included age at MMR, date of administration of MMR, MMR brand and batch number, and the General Practice at which MMR was administered. The risk factors analysed included age at vaccination, time of vaccination, class and the GP practice where MMR was administered. Statistical analysis was performed using Epi info 7 and SPSS v24.Results: Thirteen children in the cohort developed measles during the outbreak. All children in the cohort were age-appropriately vaccinated, with one dose of MMR vaccine. Analysis demonstrated statistically significant differences in the relative risk of developing measles according to the class a child was in, and the General Practice at which they were vaccinated.Conclusions: The reason for intense measles activity in one class was not established. Although a concurrent investigation into cold chain and vaccine stock management did not identify a cause for the high relative risk of measles in children vaccinated, recommendations were made for improving cold chain and vaccine stock management in General Practices. [ABSTRACT FROM AUTHOR]

Fas (CD95) signalling is best known for its role in apoptosis, however, recent reports have shown it to be involved in other cellular responses as well, including inflammation. Fas and its adaptor protein FADD are known to negatively regulate LPS‐induced proinflammatory responses, but their role in LPS‐induced type I interferon production is unknown. Here, we demonstrate that Fas engagement on macrophages, using an agonistic Fas antibody CH11, augments LPS‐induced NF‐κB responses, causing increased production of TNFα, IL‐8, IL‐6 and IL‐12. Conversely, costimulation with both LPS and CH11 causes a significant reduction in the level of interferon‐beta (IFNβ) production. This differential effect involves the Fas adaptor FADD because while LPS‐induced IL‐6 production increased in FADD−/− murine embryonic fibroblasts, LPS‐induced IFNβ production was significantly reduced in these cells. Overexpression of a dominant negative form of FADD (FADD‐DD) inhibits LPS‐induced IFNβ luciferase but not LPS‐induced NF‐κB luciferase. In contrast, overexpression of full‐length FADD inhibited LPS‐induced NF‐κB luciferase activation but was seen to augment LPS‐induced IFNβ luciferase. Moreover, FADD‐DD inhibits TRIF‐, TRAM‐, IKKε‐, TBK‐1‐ and TRAF3‐induced IFNβ luciferase production, with coimmunoprecipitation experiments demonstrating an interaction between FADD and TRIF. These data identify FADD as a novel component of the noncanonical Toll‐like receptor 4/IFNβ signalling pathway and demonstrate that both Fas and its adaptor FADD can differentially regulate the production of LPS‐induced proinflammatory cytokines and type I interferons. We have identified that the death receptor Fas and its adaptor protein FADD are able to differentially regulate the MYD88‐dependent and ‐independent arms of the TLR4 signalling pathway. FADD is a negative regulator of the MyD88‐dependent arm (A) but is an essential component of the MyD88‐independent pathway (B), facilitating induction of LPS‐induced IFN‐beta through an interaction with TRIF. [ABSTRACT FROM AUTHOR]

Recent critiques of both the uses of and discourse surrounding big data have raised important questions as to the extent to which big data and big data techniques should be embraced. However, while the contextdependence of data has been recognized, there remains a tendency among social theorists and other commentators to treat certain aspects of the big data phenomenon, including not only the data but also the methods and tools used to move from data as database to data that can be interpreted and assigned meaning, in a homogenizing way. In this paper, we seek to challenge this tendency, and to explore the ways in which explicit consideration of the plurality of big data might inform particular instances of its exploitation. We compare one currently popular big data-inspired innovation — learning analytics — with three other big data contexts — the physical sciences, business intelligence and public health. Through these comparisons, we highlight some dangers of learning analytics implemented without substantial theoretical, ethical and design effort. In so doing, we also highlight just how plural data, analytical approaches and intentions are, and suggest that each new big data context needs to be recognized in its own singularity. [ABSTRACT FROM AUTHOR]

Learning analytic implementations are increasingly being included in learning management systems in higher education. We lay out some concerns with the way learning analytics – both data and algorithms – are often presented within an unproblematized Big Data discourse. We describe some potential problems with the often implicit assumptions about learning and learners – and indeed the tendency not to theorize learning explicitly – that underpin such implementations. Finally, we describe an attempt to devise our own analytics, grounded in a sociomaterial conception of learning. We use the data obtained to suggest that the relationships between learning and the digital traces left by participants in online learning are far from trivial, and that any analytics that relies on these as proxies for learning tends towards a behaviorist evaluation of learning processes. [ABSTRACT FROM PUBLISHER]

Purpose: Paediatric Epilepsy surgery in the UK has recently been centralised in order to improve expertise and quality of service available to children. Video EEG monitoring or telemetry is a highly specialised and a crucial component of the pre-surgical evaluation. Although many Epilepsy Monitoring Units work to certain standards, there is no national or international guideline for paediatric video telemetry.Methods: Due to lack of evidence we used a modified Delphi process utilizing the clinical and academic expertise of the clinical neurophysiology sub-specialty group of Children's Epilepsy Surgical Service (CESS) centres in England and Wales. This process consisted of the following stages I: Identification of the consensus working group, II: Identification of key areas for guidelines, III: Consensus practice points and IV: Final review. Statements that gained consensus (median score of either 4 or 5 using a five-point Likerttype scale) were included in the guideline.Results: Two rounds of feedback and amendments were undertaken. The consensus guidelines includes the following topics: referral pathways, neurophysiological equipment standards, standards of recording techniques, with specific emphasis on safety of video EEG monitoring both with and without drug withdrawal, a protocol for testing patient's behaviours, data storage and guidelines for writing factual reports and conclusions. All statements developed received a median score of 5 and were adopted by the group.Conclusion: Using a modified Delphi process we were able to develop universally-accepted video EEG guidelines for the UK CESS. Although these recommendations have been specifically developed for the pre-surgical evaluation of children with epilepsy, it is assumed that most components are transferable to any paediatric video EEG monitoring setting. [ABSTRACT FROM AUTHOR]

High prevalence rates of aggression during adolescence and associated adjustment difficulties for perpetrators and victims highlight the need for effective violence prevention programs. School-based prevention programs are advantageous as they occur in a key setting for youths' social and emotional development. The current study compared the efficacy of a combined universal violence prevention approach that included individual-level skill-building (i.e., lessons from Second Step) and school environment (i.e., Olweus Bullying Prevention Program; OBPP) interventions to OBPP alone. Participants were 231 sixth, seventh, and eighth graders (ages 11-15; M = 12.6, SD = 1.0) in middle school (48 % male, 67 % African American). A total of 14 classrooms were randomly assigned to the combined intervention (seven) or OBPP only comparison (seven) condition, split evenly across grades. Intervention effects were moderated by disability status and gender. Among students without disabilities those who received the combined intervention reported greater increases in anger regulation coping skills than those in the comparison condition. In contrast, among youth with disabilities greater increases in teacher-rated social skills were found for students in the combined intervention than students in the comparison condition at posttest. Gender-moderated effects included greater decreases in teacher ratings of externalizing problems and bullying behaviors for boys in the combined intervention versus the comparison condition at posttest. Study results inform school-based violence prevention programs and are discussed along with implications. [ABSTRACT FROM AUTHOR]

The current study examined longitudinal relations between overt and relational victimization, sadness and anger dysregulation, and depressive and anxiety symptoms across 6 months among an ethnically diverse sample of sixth graders (N = 485; 48% male; 65% African American). No direct longitudinal relations were found between peer victimization and internalizing symptoms or between internalizing symptoms and peer victimization, and these findings were consistent across gender and disability status. The relation between overt victimization and subsequent increases in relational victimization was stronger for youth with versus without high incidence disabilities. Significant indirect effects were found for overt victimization on both depressive and anxiety symptoms via sadness dysregulation. The strength of the indirect effects did not differ by gender. Findings highlight the merits of school-based violence prevention programs that address emotional management and are embedded within multi-tiered school environment interventions. [ABSTRACT FROM AUTHOR]

Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization. Although activation of the immune system is implicated in disease progression, pathological pathways remain diverse and unclear. Here, we report an unexpected protective role of a pro-inflammatory cytokine, interleukin-33 (IL-33), in ocular angiogenesis. IL-33 and its receptor (ST2) are expressed constitutively in human and murine retina and choroid. When RPE was activated, IL-33 expression was markedly elevated in vitro. We found that IL-33 regulated tissue remodelling by attenuating wound-healing responses, including reduction in the migration of choroidal fibroblasts and retinal microvascular endothelial cells, and inhibition of collagen gel contraction. In vivo, local administration of recombinant IL-33 inhibited murine choroidal neovascularization (CNV) formation, a surrogate of human neovascular AMD, and this effect was ST2-dependent. Collectively, these data demonstrate IL-33 as a potential immunotherapy and distinguishes pathways for subverting AMD pathology. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Reclamation of mine waste rock piles typically consists of constructing a cover with amendments to improve conditions for vegetation. However, cover amendments have potential to mobilize metals in waste by introducing new chemicals and altering pH and redox conditions. This study evaluates metal phases in a 100-year-old waste rock pile with high metals content (3.5% lead by weight, 0.8% zinc, and 0.75% copper) and the potential for these metals to be mobilized by several cover materials and amendments (topsoil, spent brewery grain, biochar, compost, commercial soil media, and phosphate). Laboratory testing indicates that metals have weathered from their initial metal sulfide phases (galena, sphalerite, chalcopyrite), and are now also present as sulfates, phosphates, carbonates, and phases associated with manganese/iron oxides. Sequential extraction tests demonstrated that the largest extractable fraction of metals is associated with manganese/iron oxides (37% of lead by weight, 22% of copper, and 26% of zinc), suggesting an environmental risk should geochemically reducing conditions develop and mobilize metals in the pile after cover construction. Testing of specific cover materials demonstrated that metals mobilization also occurs from low pH (as with spent brewery grain), formation of stable aqueous metal–organic complexes (as with spent brewery grain and compost), and ligand exchange (as with phosphate amendment). Results of this study demonstrate the importance of identifying metal phases present in a waste rock pile prior to selecting cover amendments. • Metal phases were studied in historical waste rock for a polymetallic sulfide mine. • Cover amendments were tested to evaluate their potential to mobilize metals. • Metals release will occur should geochemically reducing conditions develop. • Organic amendments formed stable aqueous metal–organic complexes. • Metal phases in waste should be identified prior to selection of cover materials. [ABSTRACT FROM AUTHOR]