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151. Deep Co-Image-Label Hashing for Multi-Label Image Retrieval

Author

Shen, X, Dong, G, Zheng, Y, Lan, L, Tsang, I, Sun, QS, Shen, X, Dong, G, Zheng, Y, Lan, L, Tsang, I, and Sun, QS

Abstract

Deep supervised hashing has greatly improved retrieval performance with the powerful learning capability of deep neural network. In multi-label image retrieval, existing deep hashing simply indicates whether two images are similar by constructing a similarity matrix. However, it ignores the dependency among multiple labels that has been shown important in multi-label application. To fulfill this gap, this paper proposes Deep Co-Image-Label Hashing (DCILH) to discover label dependency. Specifically, DCILH regards image and label as two views, and maps the two views into a common deep Hamming space. DCILH proposes to learn prototype for each label, and preserve similarity among images, labels, and prototypes. To exploit label dependency, DCILH further employs the label-correlation aware loss on the predicted labels, such that predicted output on positive label is enforced to be larger than that on negative label. Extensive experiments on several multi-label benchmarks demonstrate the proposed DCILH outperforms state-of-the-art deep supervised hashing on large-scale multi-label image retrieval.

Published
2022

152. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy

Author

Fenstermacher, M. E., Abbate, J., Abe, S., Abrams, T., Adams, M., Adamson, B., Aiba, N., Akiyama, T., Aleynikov, P., Allen, E., Allen, S., Anand, H., Anderson, J., Andrew, Y., Andrews, T., Appelt, D., Arbon, R., Ashikawa, N., Ashourvan, A., Aslin, M., Asnis, Y., Austin, M., Ayala, D., Bak, J., Bandyopadhyay, I., Banerjee, S., Barada, K., Bardoczi, L., Barr, J., Bass, E., Battaglia, D., Battey, A., Baumgartner, W., Baylor, L., Beckers, J., Beidler, M., Belli, E., Berkery, J., Bernard, T., Bertelli, N., Beurskens, M., Bielajew, R., Bilgili, S., Biswas, B., Blondel, S., Boedo, J., Bogatu, I., Boivin, R., Bolzonella, T., Bongard, M., Bonnin, X., Bonoli, P., Bonotto, M., Bortolon, A., Bose, S., Bosviel, N., Bouwmans, S., Boyer, M., Boyes, W., Bradley, L., Brambila, R., Brennan, D., Bringuier, S., Brodsky, L., Brookman, M., Brooks, J., Brower, D., Brown, G., Brown, W., Burke, M., Burrell, K., Butler, K., Buttery, R., Bykov, I., Byrne, P., Cacheris, A., Callahan, K., Callen, J., Campbell, G., Candy, J., Canik, J., Cano-Megias, P., Cao, N., Carayannopoulos, L., Carlstrom, T., Carrig, W., Carter, T., Cary, W., Casali, L., Cengher, M., Cespedes Paz, G., Chaban, R., Chan, V., Chapman, B., Char, I., Chattopadhyay, A., Chen, R., Chen, J., Chen, X., Chen, M., Chen, Z., Choi, M., Choi, W., Choi, G., Chousal, L., Chrobak, C., Chrystal, C., Chung, Y., Churchill, R., Cianciosa, M., Clark, J., Clement, M., Coda, S., Cole, A., Collins, C., Conlin, W., Cooper, A., Cordell, J., Coriton, B., Cote, T., Cothran, J., Creely, A., Crocker, N., Crowe, C., Crowley, B., Crowley, T., Cruz-Zabala, D., Cummings, D., Curie, M., Curreli, D., Dal Molin, A., Dannels, B., Dautt-Silva, A., Davda, K., De Tommasi, G., De Vries, P., Degrandchamp, G., Degrassie, J., Demers, D., Denk, S., Depasquale, S., Deshazer, E., Diallo, A., Diem, S., Dimits, A., Ding, R., Ding, S., Ding, W., Do, T., Doane, J., Dong, G., Donovan, D., Drake, J., Drews, W., Drobny, J., Du, X., Du, H., Duarte, V., Dudt, D., Dunn, C., Duran, J., Dvorak, A., Effenberg, F., Eidietis, N., Elder, D., Eldon, D., Ellis, R., Elwasif, W., Ennis, D., Erickson, K., Ernst, D., Fasciana, M., Fedorov, D., Feibush, E., Ferraro, N., Ferreira, J., Ferron, J., Fimognari, P., Finkenthal, D., Fitzpatrick, R., Fox, P., Fox, W., Frassinetti, L., Frerichs, H., Frye, H., Fu, Y., Gage, K., Galdon Quiroga, J., Gallo, A., Gao, Q., Garcia, A., Garcia Munoz, M., Garnier, D., Garofalo, A., Gattuso, A., Geng, D., Gentle, K., Ghosh, D., Giacomelli, L., Gibson, S., Gilson, E., Giroud, C., Glass, F., Glasser, A., Glibert, D., Gohil, P., Gomez, R., Gomez, S., Gong, X., Gonzales, E., Goodman, A., Gorelov, Y., Graber, V., Granetz, R., Gray, T., Green, D., Greenfield, C., Greenwald, M., Grierson, B., Groebner, R., Grosnickle, W., Groth, M., Grunloh, H., Gu, S., Guo, W., Guo, H., Gupta, P., Guterl, J., Guttenfelder, W., Guzman, T., Haar, S., Hager, R., Hahn, S., Halfmoon, M., Hall, T., Hallatschek, K., Halpern, F., Hammett, G., Han, H., Hansen, E., Hansen, C., Hansink, M., Hanson, J., Hanson, M., Hao, G., Harris, A., Harvey, R., Haskey, S., Hassan, E., Hassanein, A., Hatch, D., Hawryluk, R., Hayashi, W., Heidbrink, W., Herfindal, J., Hicok, J., Hill, D., Hinson, E., Holcomb, C., Holland, L., Holland, C., Hollmann, E., Hollocombe, J., Holm, A., Holmes, I., Holtrop, K., Honda, M., Hong, R., Hood, R., Horton, A., Horvath, L., Hosokawa, M., Houshmandyar, S., Howard, N., Howell, E., Hoyt, D., Hu, W., Hu, Y., Hu, Q., Huang, J., Huang, Y., Hughes, J., Human, T., Humphreys, D., Huynh, P., Hyatt, A., Ibanez, C., Ibarra, L., Icasas, R., Ida, K., Igochine, V., In, Y., Inoue, S., Isayama, A., Izacard, O., Izzo, V., Jackson, A., Jacobsen, G., Jaervinen, A., Jalalvand, A., Janhunen, J., Jardin, S., Jarleblad, H., Jeon, Y., Ji, H., Jian, X., Joffrin, E., Johansen, A., Johnson, C., Johnson, T., Jones, C., Joseph, I., Jubas, D., Junge, B., Kalb, W., Kalling, R., Kamath, C., Kang, J., Kaplan, D., Kaptanoglu, A., Kasdorf, S., Kates-Harbeck, J., Kazantzidis, P., Kellman, A., Kellman, D., Kessel, C., Khumthong, K., Kim, E., Kim, H., Kim, J., Kim, S., Kim, K., Kim, C., Kimura, W., King, M., King, J., Kinsey, J., Kirk, A., Kiyan, B., Kleiner, A., Klevarova, V., Knapp, R., Knolker, M., Ko, W., Kobayashi, T., Koch, E., Kochan, M., Koel, B., Koepke, M., Kohn, A., Kolasinski, R., Kolemen, E., Kostadinova, E., Kostuk, M., Kramer, G., Kriete, D., Kripner, L., Kubota, S., Kulchar, J., Kwon, K., La Haye, R., Laggner, F., Lan, H., Lantsov, R., Lao, L., Lasa Esquisabel, A., Lasnier, C., Lau, C., Leard, B., Lee, J., Lee, R., Lee, M., Lee, Y., Lee, C., Lee, S., Lehnen, M., Leonard, A., Leppink, E., Lesher, M., Lestz, J., Leuer, J., Leuthold, N., Li, X., Li, K., Li, E., Li, G., Li, L., Li, Z., Li, J., Li, Y., Lin, Z., Lin, D., Liu, X., Liu, J., Liu, Y., Liu, T., Liu, C., Liu, Z., Liu, D., Liu, A., Loarte-Prieto, A., Lodestro, L., Logan, N., Lohr, J., Lombardo, B., Lore, J., Luan, Q., Luce, T., Luda Di Cortemiglia, T., Luhmann, N., Lunsford, R., Luo, Z., Lvovskiy, A., Lyons, B., Ma, X., Madruga, M., Madsen, B., Maggi, C., Maheshwari, K., Mail, A., Mailloux, J., Maingi, R., Major, M., Makowski, M., Manchanda, R., Marini, C., Marinoni, A., Maris, A., Markovic, T., Marrelli, L., Martin, E., Mateja, J., Matsunaga, G., Maurizio, R., Mauzey, P., Mauzey, D., McArdle, G., McClenaghan, J., McCollam, K., McDevitt, C., McKay, K., McKee, G., McLean, A., Mehta, V., Meier, E., Menard, J., Meneghini, O., Merlo, G., Messer, S., Meyer, W., Michael, C., Michoski, C., Milne, P., Minet, G., Misleh, A., Mitrishkin, Y., Moeller, C., Montes, K., Morales, M., Mordijck, S., Moreau, D., Morosohk, S., Morris, P., Morton, L., Moser, A., Moyer, R., Moynihan, C., Mrazkova, T., Mueller, D., Munaretto, S., Munoz Burgos, J., Murphy, C., Murphy, K., Muscatello, C., Myers, C., Nagy, A., Nandipati, G., Navarro, M., Nave, F., Navratil, G., Nazikian, R., Neff, A., Neilson, G., Neiser, T., Neiswanger, W., Nelson, D., Nelson, A., Nespoli, F., Nguyen, R., Nguyen, L., Nguyen, X., Nichols, J., Nocente, M., Nogami, S., Noraky, S., Norausky, N., Nornberg, M., Nygren, R., Odstrcil, T., Ogas, D., Ogorman, T., Ohdachi, S., Ohtani, Y., Okabayashi, M., Okamoto, M., Olavson, L., Olofsson, E., Omullane, M., Oneill, R., Orlov, D., Orvis, W., Osborne, T., Pace, D., Paganini Canal, G., Pajares Martinez, A., Palacios, L., Pan, C., Pan, Q., Pandit, R., Pandya, M., Pankin, A., Park, Y., Park, J., Parker, S., Parks, P., Parsons, M., Patel, B., Pawley, C., Paz-Soldan, C., Peebles, W., Pelton, S., Perillo, R., Petty, C., Peysson, Y., Pierce, D., Pigarov, A., Pigatto, L., Piglowski, D., Pinches, S., Pinsker, R., Piovesan, P., Piper, N., Pironti, A., Pitts, R., Pizzo, J., Plank, U., Podesta, M., Poli, E., Poli, F., Ponce, D., Popovic, Z., Porkolab, M., Porter, G., Powers, C., Powers, S., Prater, R., Pratt, Q., Pusztai, I., Qian, J., Qin, X., Ra, O., Rafiq, T., Raines, T., Raman, R., Rauch, J., Raymond, A., Rea, C., Reich, M., Reiman, A., Reinhold, S., Reinke, M., Reksoatmodjo, R., Ren, Q., Ren, Y., Ren, J., Rensink, M., Renteria, J., Rhodes, T., Rice, J., Roberts, R., Robinson, J., Rodriguez Fernandez, P., Rognlien, T., Rosenthal, A., Rosiello, S., Rost, J., Roveto, J., Rowan, W., Rozenblat, R., Ruane, J., Rudakov, D., Ruiz Ruiz, J., Rupani, R., Saarelma, S., Sabbagh, S., Sachdev, J., Saenz, J., Saib, S., Salewski, M., Salmi, A., Sammuli, B., Samuell, C., Sandorfi, A., Sang, C., Sarff, J., Sauter, O., Schaubel, K., Schmitz, L., Schmitz, O., Schneider, J., Schroeder, P., Schultz, K., Schuster, E., Schwartz, J., Sciortino, F., Scotti, F., Scoville, J., Seltzman, A., Seol, S., Sfiligoi, I., Shafer, M., Sharapov, S., Shen, H., Sheng, Z., Shepard, T., Shi, S., Shibata, Y., Shin, G., Shiraki, D., Shousha, R., Si, H., Simmerling, P., Sinclair, G., Sinha, J., Sinha, P., Sips, G., Sizyuk, T., Skinner, C., Sladkomedova, A., Slendebroek, T., Slief, J., Smirnov, R., Smith, J., Smith, S., Smith, D., Snipes, J., Snoep, G., Snyder, A., Snyder, P., Solano, E., Solomon, W., Song, J., Sontag, A., Soukhanovskii, V., Spendlove, J., Spong, D., Squire, J., Srinivasan, C., Stacey, W., Staebler, G., Stagner, L., Stange, T., Stangeby, P., Stefan, R., Stemprok, R., Stephan, D., Stillerman, J., Stoltzfus-Dueck, T., Stonecipher, W., Storment, S., Strait, E., Su, D., Sugiyama, L., Sun, Y., Sun, P., Sun, Z., Sun, A., Sundstrom, D., Sung, C., Sungcoco, J., Suttrop, W., Suzuki, Y., Suzuki, T., Svyatkovskiy, A., Swee, C., Sweeney, R., Sweetnam, C., Szepesi, G., Takechi, M., Tala, T., Tanaka, K., Tang, X., Tang, S., Tao, Y., Tao, R., Taussig, D., Taylor, T., Teixeira, K., Teo, K., Theodorsen, A., Thomas, D., Thome, K., Thorman, A., Thornton, A., Ti, A., Tillack, M., Timchenko, N., Tinguely, R., Tompkins, R., Tooker, J., Torrezan De Sousa, A., Trevisan, G., Tripathi, S., Trujillo Ochoa, A., Truong, D., Tsui, C., Turco, F., Turnbull, A., Umansky, M., Unterberg, E., Vaezi, P., Vail, P., Valdez, J., Valkis, W., Van Compernolle, B., Van Galen, J., Van Kampen, R., Van Zeeland, M., Verdoolaege, G., Vianello, N., Victor, B., Viezzer, E., Vincena, S., Wade, M., Waelbroeck, F., Wai, J., Wakatsuki, T., Walker, M., Wallace, G., Waltz, R., Wampler, W., Wang, L., Wang, H., Wang, Y., Wang, Z., Wang, G., Ward, S., Watkins, M., Watkins, J., Wehner, W., Wei, Y., Weiland, M., Weisberg, D., Welander, A., White, A., White, R., Wiesen, S., Wilcox, R., Wilks, T., Willensdorfer, M., Wilson, H., Wingen, A., Wolde, M., Wolff, M., Woller, K., Wolz, A., Wong, H., Woodruff, S., Wu, M., Wu, Y., Wukitch, S., Wurden, G., Xiao, W., Xie, R., Xing, Z., Xu, X., Xu, C., Xu, G., Yan, Z., Yang, X., Yang, S., Yokoyama, T., Yoneda, R., Yoshida, M., You, K., Younkin, T., Yu, J., Yu, M., Yu, G., Yuan, Q., Zaidenberg, L., Zakharov, L., Zamengo, A., Zamperini, S., Zarnstorff, M., Zeger, E., Zeller, K., Zeng, L., Zerbini, M., Zhang, L., Zhang, X., Zhang, R., Zhang, B., Zhang, J., Zhao, L., Zhao, B., Zheng, Y., Zheng, L., Zhu, B., Zhu, J., Zhu, Y., Zsutty, M., Zuin, M., Fenstermacher, M. E., Abbate, J., Abe, S., Abrams, T., Adams, M., Adamson, B., Aiba, N., Akiyama, T., Aleynikov, P., Allen, E., Allen, S., Anand, H., Anderson, J., Andrew, Y., Andrews, T., Appelt, D., Arbon, R., Ashikawa, N., Ashourvan, A., Aslin, M., Asnis, Y., Austin, M., Ayala, D., Bak, J., Bandyopadhyay, I., Banerjee, S., Barada, K., Bardoczi, L., Barr, J., Bass, E., Battaglia, D., Battey, A., Baumgartner, W., Baylor, L., Beckers, J., Beidler, M., Belli, E., Berkery, J., Bernard, T., Bertelli, N., Beurskens, M., Bielajew, R., Bilgili, S., Biswas, B., Blondel, S., Boedo, J., Bogatu, I., Boivin, R., Bolzonella, T., Bongard, M., Bonnin, X., Bonoli, P., Bonotto, M., Bortolon, A., Bose, S., Bosviel, N., Bouwmans, S., Boyer, M., Boyes, W., Bradley, L., Brambila, R., Brennan, D., Bringuier, S., Brodsky, L., Brookman, M., Brooks, J., Brower, D., Brown, G., Brown, W., Burke, M., Burrell, K., Butler, K., Buttery, R., Bykov, I., Byrne, P., Cacheris, A., Callahan, K., Callen, J., Campbell, G., Candy, J., Canik, J., Cano-Megias, P., Cao, N., Carayannopoulos, L., Carlstrom, T., Carrig, W., Carter, T., Cary, W., Casali, L., Cengher, M., Cespedes Paz, G., Chaban, R., Chan, V., Chapman, B., Char, I., Chattopadhyay, A., Chen, R., Chen, J., Chen, X., Chen, M., Chen, Z., Choi, M., Choi, W., Choi, G., Chousal, L., Chrobak, C., Chrystal, C., Chung, Y., Churchill, R., Cianciosa, M., Clark, J., Clement, M., Coda, S., Cole, A., Collins, C., Conlin, W., Cooper, A., Cordell, J., Coriton, B., Cote, T., Cothran, J., Creely, A., Crocker, N., Crowe, C., Crowley, B., Crowley, T., Cruz-Zabala, D., Cummings, D., Curie, M., Curreli, D., Dal Molin, A., Dannels, B., Dautt-Silva, A., Davda, K., De Tommasi, G., De Vries, P., Degrandchamp, G., Degrassie, J., Demers, D., Denk, S., Depasquale, S., Deshazer, E., Diallo, A., Diem, S., Dimits, A., Ding, R., Ding, S., Ding, W., Do, T., Doane, J., Dong, G., Donovan, D., Drake, J., Drews, W., Drobny, J., Du, X., Du, H., Duarte, V., Dudt, D., Dunn, C., Duran, J., Dvorak, A., Effenberg, F., Eidietis, N., Elder, D., Eldon, D., Ellis, R., Elwasif, W., Ennis, D., Erickson, K., Ernst, D., Fasciana, M., Fedorov, D., Feibush, E., Ferraro, N., Ferreira, J., Ferron, J., Fimognari, P., Finkenthal, D., Fitzpatrick, R., Fox, P., Fox, W., Frassinetti, L., Frerichs, H., Frye, H., Fu, Y., Gage, K., Galdon Quiroga, J., Gallo, A., Gao, Q., Garcia, A., Garcia Munoz, M., Garnier, D., Garofalo, A., Gattuso, A., Geng, D., Gentle, K., Ghosh, D., Giacomelli, L., Gibson, S., Gilson, E., Giroud, C., Glass, F., Glasser, A., Glibert, D., Gohil, P., Gomez, R., Gomez, S., Gong, X., Gonzales, E., Goodman, A., Gorelov, Y., Graber, V., Granetz, R., Gray, T., Green, D., Greenfield, C., Greenwald, M., Grierson, B., Groebner, R., Grosnickle, W., Groth, M., Grunloh, H., Gu, S., Guo, W., Guo, H., Gupta, P., Guterl, J., Guttenfelder, W., Guzman, T., Haar, S., Hager, R., Hahn, S., Halfmoon, M., Hall, T., Hallatschek, K., Halpern, F., Hammett, G., Han, H., Hansen, E., Hansen, C., Hansink, M., Hanson, J., Hanson, M., Hao, G., Harris, A., Harvey, R., Haskey, S., Hassan, E., Hassanein, A., Hatch, D., Hawryluk, R., Hayashi, W., Heidbrink, W., Herfindal, J., Hicok, J., Hill, D., Hinson, E., Holcomb, C., Holland, L., Holland, C., Hollmann, E., Hollocombe, J., Holm, A., Holmes, I., Holtrop, K., Honda, M., Hong, R., Hood, R., Horton, A., Horvath, L., Hosokawa, M., Houshmandyar, S., Howard, N., Howell, E., Hoyt, D., Hu, W., Hu, Y., Hu, Q., Huang, J., Huang, Y., Hughes, J., Human, T., Humphreys, D., Huynh, P., Hyatt, A., Ibanez, C., Ibarra, L., Icasas, R., Ida, K., Igochine, V., In, Y., Inoue, S., Isayama, A., Izacard, O., Izzo, V., Jackson, A., Jacobsen, G., Jaervinen, A., Jalalvand, A., Janhunen, J., Jardin, S., Jarleblad, H., Jeon, Y., Ji, H., Jian, X., Joffrin, E., Johansen, A., Johnson, C., Johnson, T., Jones, C., Joseph, I., Jubas, D., Junge, B., Kalb, W., Kalling, R., Kamath, C., Kang, J., Kaplan, D., Kaptanoglu, A., Kasdorf, S., Kates-Harbeck, J., Kazantzidis, P., Kellman, A., Kellman, D., Kessel, C., Khumthong, K., Kim, E., Kim, H., Kim, J., Kim, S., Kim, K., Kim, C., Kimura, W., King, M., King, J., Kinsey, J., Kirk, A., Kiyan, B., Kleiner, A., Klevarova, V., Knapp, R., Knolker, M., Ko, W., Kobayashi, T., Koch, E., Kochan, M., Koel, B., Koepke, M., Kohn, A., Kolasinski, R., Kolemen, E., Kostadinova, E., Kostuk, M., Kramer, G., Kriete, D., Kripner, L., Kubota, S., Kulchar, J., Kwon, K., La Haye, R., Laggner, F., Lan, H., Lantsov, R., Lao, L., Lasa Esquisabel, A., Lasnier, C., Lau, C., Leard, B., Lee, J., Lee, R., Lee, M., Lee, Y., Lee, C., Lee, S., Lehnen, M., Leonard, A., Leppink, E., Lesher, M., Lestz, J., Leuer, J., Leuthold, N., Li, X., Li, K., Li, E., Li, G., Li, L., Li, Z., Li, J., Li, Y., Lin, Z., Lin, D., Liu, X., Liu, J., Liu, Y., Liu, T., Liu, C., Liu, Z., Liu, D., Liu, A., Loarte-Prieto, A., Lodestro, L., Logan, N., Lohr, J., Lombardo, B., Lore, J., Luan, Q., Luce, T., Luda Di Cortemiglia, T., Luhmann, N., Lunsford, R., Luo, Z., Lvovskiy, A., Lyons, B., Ma, X., Madruga, M., Madsen, B., Maggi, C., Maheshwari, K., Mail, A., Mailloux, J., Maingi, R., Major, M., Makowski, M., Manchanda, R., Marini, C., Marinoni, A., Maris, A., Markovic, T., Marrelli, L., Martin, E., Mateja, J., Matsunaga, G., Maurizio, R., Mauzey, P., Mauzey, D., McArdle, G., McClenaghan, J., McCollam, K., McDevitt, C., McKay, K., McKee, G., McLean, A., Mehta, V., Meier, E., Menard, J., Meneghini, O., Merlo, G., Messer, S., Meyer, W., Michael, C., Michoski, C., Milne, P., Minet, G., Misleh, A., Mitrishkin, Y., Moeller, C., Montes, K., Morales, M., Mordijck, S., Moreau, D., Morosohk, S., Morris, P., Morton, L., Moser, A., Moyer, R., Moynihan, C., Mrazkova, T., Mueller, D., Munaretto, S., Munoz Burgos, J., Murphy, C., Murphy, K., Muscatello, C., Myers, C., Nagy, A., Nandipati, G., Navarro, M., Nave, F., Navratil, G., Nazikian, R., Neff, A., Neilson, G., Neiser, T., Neiswanger, W., Nelson, D., Nelson, A., Nespoli, F., Nguyen, R., Nguyen, L., Nguyen, X., Nichols, J., Nocente, M., Nogami, S., Noraky, S., Norausky, N., Nornberg, M., Nygren, R., Odstrcil, T., Ogas, D., Ogorman, T., Ohdachi, S., Ohtani, Y., Okabayashi, M., Okamoto, M., Olavson, L., Olofsson, E., Omullane, M., Oneill, R., Orlov, D., Orvis, W., Osborne, T., Pace, D., Paganini Canal, G., Pajares Martinez, A., Palacios, L., Pan, C., Pan, Q., Pandit, R., Pandya, M., Pankin, A., Park, Y., Park, J., Parker, S., Parks, P., Parsons, M., Patel, B., Pawley, C., Paz-Soldan, C., Peebles, W., Pelton, S., Perillo, R., Petty, C., Peysson, Y., Pierce, D., Pigarov, A., Pigatto, L., Piglowski, D., Pinches, S., Pinsker, R., Piovesan, P., Piper, N., Pironti, A., Pitts, R., Pizzo, J., Plank, U., Podesta, M., Poli, E., Poli, F., Ponce, D., Popovic, Z., Porkolab, M., Porter, G., Powers, C., Powers, S., Prater, R., Pratt, Q., Pusztai, I., Qian, J., Qin, X., Ra, O., Rafiq, T., Raines, T., Raman, R., Rauch, J., Raymond, A., Rea, C., Reich, M., Reiman, A., Reinhold, S., Reinke, M., Reksoatmodjo, R., Ren, Q., Ren, Y., Ren, J., Rensink, M., Renteria, J., Rhodes, T., Rice, J., Roberts, R., Robinson, J., Rodriguez Fernandez, P., Rognlien, T., Rosenthal, A., Rosiello, S., Rost, J., Roveto, J., Rowan, W., Rozenblat, R., Ruane, J., Rudakov, D., Ruiz Ruiz, J., Rupani, R., Saarelma, S., Sabbagh, S., Sachdev, J., Saenz, J., Saib, S., Salewski, M., Salmi, A., Sammuli, B., Samuell, C., Sandorfi, A., Sang, C., Sarff, J., Sauter, O., Schaubel, K., Schmitz, L., Schmitz, O., Schneider, J., Schroeder, P., Schultz, K., Schuster, E., Schwartz, J., Sciortino, F., Scotti, F., Scoville, J., Seltzman, A., Seol, S., Sfiligoi, I., Shafer, M., Sharapov, S., Shen, H., Sheng, Z., Shepard, T., Shi, S., Shibata, Y., Shin, G., Shiraki, D., Shousha, R., Si, H., Simmerling, P., Sinclair, G., Sinha, J., Sinha, P., Sips, G., Sizyuk, T., Skinner, C., Sladkomedova, A., Slendebroek, T., Slief, J., Smirnov, R., Smith, J., Smith, S., Smith, D., Snipes, J., Snoep, G., Snyder, A., Snyder, P., Solano, E., Solomon, W., Song, J., Sontag, A., Soukhanovskii, V., Spendlove, J., Spong, D., Squire, J., Srinivasan, C., Stacey, W., Staebler, G., Stagner, L., Stange, T., Stangeby, P., Stefan, R., Stemprok, R., Stephan, D., Stillerman, J., Stoltzfus-Dueck, T., Stonecipher, W., Storment, S., Strait, E., Su, D., Sugiyama, L., Sun, Y., Sun, P., Sun, Z., Sun, A., Sundstrom, D., Sung, C., Sungcoco, J., Suttrop, W., Suzuki, Y., Suzuki, T., Svyatkovskiy, A., Swee, C., Sweeney, R., Sweetnam, C., Szepesi, G., Takechi, M., Tala, T., Tanaka, K., Tang, X., Tang, S., Tao, Y., Tao, R., Taussig, D., Taylor, T., Teixeira, K., Teo, K., Theodorsen, A., Thomas, D., Thome, K., Thorman, A., Thornton, A., Ti, A., Tillack, M., Timchenko, N., Tinguely, R., Tompkins, R., Tooker, J., Torrezan De Sousa, A., Trevisan, G., Tripathi, S., Trujillo Ochoa, A., Truong, D., Tsui, C., Turco, F., Turnbull, A., Umansky, M., Unterberg, E., Vaezi, P., Vail, P., Valdez, J., Valkis, W., Van Compernolle, B., Van Galen, J., Van Kampen, R., Van Zeeland, M., Verdoolaege, G., Vianello, N., Victor, B., Viezzer, E., Vincena, S., Wade, M., Waelbroeck, F., Wai, J., Wakatsuki, T., Walker, M., Wallace, G., Waltz, R., Wampler, W., Wang, L., Wang, H., Wang, Y., Wang, Z., Wang, G., Ward, S., Watkins, M., Watkins, J., Wehner, W., Wei, Y., Weiland, M., Weisberg, D., Welander, A., White, A., White, R., Wiesen, S., Wilcox, R., Wilks, T., Willensdorfer, M., Wilson, H., Wingen, A., Wolde, M., Wolff, M., Woller, K., Wolz, A., Wong, H., Woodruff, S., Wu, M., Wu, Y., Wukitch, S., Wurden, G., Xiao, W., Xie, R., Xing, Z., Xu, X., Xu, C., Xu, G., Yan, Z., Yang, X., Yang, S., Yokoyama, T., Yoneda, R., Yoshida, M., You, K., Younkin, T., Yu, J., Yu, M., Yu, G., Yuan, Q., Zaidenberg, L., Zakharov, L., Zamengo, A., Zamperini, S., Zarnstorff, M., Zeger, E., Zeller, K., Zeng, L., Zerbini, M., Zhang, L., Zhang, X., Zhang, R., Zhang, B., Zhang, J., Zhao, L., Zhao, B., Zheng, Y., Zheng, L., Zhu, B., Zhu, J., Zhu, Y., Zsutty, M., and Zuin, M.

Abstract

DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limit

Published
2022

158. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy

Author

Fenstermacher, M. E., primary, Abbate, J., additional, Abe, S., additional, Abrams, T., additional, Adams, M., additional, Adamson, B., additional, Aiba, N., additional, Akiyama, T., additional, Aleynikov, P., additional, Allen, E., additional, Allen, S., additional, Anand, H., additional, Anderson, J., additional, Andrew, Y., additional, Andrews, T., additional, Appelt, D., additional, Arbon, R., additional, Ashikawa, N., additional, Ashourvan, A., additional, Aslin, M., additional, Asnis, Y., additional, Austin, M., additional, Ayala, D., additional, Bak, J., additional, Bandyopadhyay, I., additional, Banerjee, S., additional, Barada, K., additional, Bardoczi, L., additional, Barr, J., additional, Bass, E., additional, Battaglia, D., additional, Battey, A., additional, Baumgartner, W., additional, Baylor, L., additional, Beckers, J., additional, Beidler, M., additional, Belli, E., additional, Berkery, J., additional, Bernard, T., additional, Bertelli, N., additional, Beurskens, M., additional, Bielajew, R., additional, Bilgili, S., additional, Biswas, B., additional, Blondel, S., additional, Boedo, J., additional, Bogatu, I., additional, Boivin, R., additional, Bolzonella, T., additional, Bongard, M., additional, Bonnin, X., additional, Bonoli, P., additional, Bonotto, M., additional, Bortolon, A., additional, Bose, S., additional, Bosviel, N., additional, Bouwmans, S., additional, Boyer, M., additional, Boyes, W., additional, Bradley, L., additional, Brambila, R., additional, Brennan, D., additional, Bringuier, S., additional, Brodsky, L., additional, Brookman, M., additional, Brooks, J., additional, Brower, D., additional, Brown, G., additional, Brown, W., additional, Burke, M., additional, Burrell, K., additional, Butler, K., additional, Buttery, R., additional, Bykov, I., additional, Byrne, P., additional, Cacheris, A., additional, Callahan, K., additional, Callen, J., additional, Campbell, G., additional, Candy, J., additional, Canik, J., additional, Cano-Megias, P., additional, Cao, N., additional, Carayannopoulos, L., additional, Carlstrom, T., additional, Carrig, W., additional, Carter, T., additional, Cary, W., additional, Casali, L., additional, Cengher, M., additional, Cespedes Paz, G., additional, Chaban, R., additional, Chan, V., additional, Chapman, B., additional, Char, I., additional, Chattopadhyay, A., additional, Chen, R., additional, Chen, J., additional, Chen, X., additional, Chen, M., additional, Chen, Z., additional, Choi, M., additional, Choi, W., additional, Choi, G., additional, Chousal, L., additional, Chrobak, C., additional, Chrystal, C., additional, Chung, Y., additional, Churchill, R., additional, Cianciosa, M., additional, Clark, J., additional, Clement, M., additional, Coda, S., additional, Cole, A., additional, Collins, C., additional, Conlin, W., additional, Cooper, A., additional, Cordell, J., additional, Coriton, B., additional, Cote, T., additional, Cothran, J., additional, Creely, A., additional, Crocker, N., additional, Crowe, C., additional, Crowley, B., additional, Crowley, T., additional, Cruz-Zabala, D., additional, Cummings, D., additional, Curie, M., additional, Curreli, D., additional, Dal Molin, A., additional, Dannels, B., additional, Dautt-Silva, A., additional, Davda, K., additional, De Tommasi, G., additional, De Vries, P., additional, Degrandchamp, G., additional, Degrassie, J., additional, Demers, D., additional, Denk, S., additional, Depasquale, S., additional, Deshazer, E., additional, Diallo, A., additional, Diem, S., additional, Dimits, A., additional, Ding, R., additional, Ding, S., additional, Ding, W., additional, Do, T., additional, Doane, J., additional, Dong, G., additional, Donovan, D., additional, Drake, J., additional, Drews, W., additional, Drobny, J., additional, Du, X., additional, Du, H., additional, Duarte, V., additional, Dudt, D., additional, Dunn, C., additional, Duran, J., additional, Dvorak, A., additional, Effenberg, F., additional, Eidietis, N., additional, Elder, D., additional, Eldon, D., additional, Ellis, R., additional, Elwasif, W., additional, Ennis, D., additional, Erickson, K., additional, Ernst, D., additional, Fasciana, M., additional, Fedorov, D., additional, Feibush, E., additional, Ferraro, N., additional, Ferreira, J., additional, Ferron, J., additional, Fimognari, P., additional, Finkenthal, D., additional, Fitzpatrick, R., additional, Fox, P., additional, Fox, W., additional, Frassinetti, L., additional, Frerichs, H., additional, Frye, H., additional, Fu, Y., additional, Gage, K., additional, Galdon Quiroga, J., additional, Gallo, A., additional, Gao, Q., additional, Garcia, A., additional, Garcia Munoz, M., additional, Garnier, D., additional, Garofalo, A., additional, Gattuso, A., additional, Geng, D., additional, Gentle, K., additional, Ghosh, D., additional, Giacomelli, L., additional, Gibson, S., additional, Gilson, E., additional, Giroud, C., additional, Glass, F., additional, Glasser, A., additional, Glibert, D., additional, Gohil, P., additional, Gomez, R., additional, Gomez, S., additional, Gong, X., additional, Gonzales, E., additional, Goodman, A., additional, Gorelov, Y., additional, Graber, V., additional, Granetz, R., additional, Gray, T., additional, Green, D., additional, Greenfield, C., additional, Greenwald, M., additional, Grierson, B., additional, Groebner, R., additional, Grosnickle, W., additional, Groth, M., additional, Grunloh, H., additional, Gu, S., additional, Guo, W., additional, Guo, H., additional, Gupta, P., additional, Guterl, J., additional, Guttenfelder, W., additional, Guzman, T., additional, Haar, S., additional, Hager, R., additional, Hahn, S., additional, Halfmoon, M., additional, Hall, T., additional, Hallatschek, K., additional, Halpern, F., additional, Hammett, G., additional, Han, H., additional, Hansen, E., additional, Hansen, C., additional, Hansink, M., additional, Hanson, J., additional, Hanson, M., additional, Hao, G., additional, Harris, A., additional, Harvey, R., additional, Haskey, S., additional, Hassan, E., additional, Hassanein, A., additional, Hatch, D., additional, Hawryluk, R., additional, Hayashi, W., additional, Heidbrink, W., additional, Herfindal, J., additional, Hicok, J., additional, Hill, D., additional, Hinson, E., additional, Holcomb, C., additional, Holland, L., additional, Holland, C., additional, Hollmann, E., additional, Hollocombe, J., additional, Holm, A., additional, Holmes, I., additional, Holtrop, K., additional, Honda, M., additional, Hong, R., additional, Hood, R., additional, Horton, A., additional, Horvath, L., additional, Hosokawa, M., additional, Houshmandyar, S., additional, Howard, N., additional, Howell, E., additional, Hoyt, D., additional, Hu, W., additional, Hu, Y., additional, Hu, Q., additional, Huang, J., additional, Huang, Y., additional, Hughes, J., additional, Human, T., additional, Humphreys, D., additional, Huynh, P., additional, Hyatt, A., additional, Ibanez, C., additional, Ibarra, L., additional, Icasas, R., additional, Ida, K., additional, Igochine, V., additional, In, Y., additional, Inoue, S., additional, Isayama, A., additional, Izacard, O., additional, Izzo, V., additional, Jackson, A., additional, Jacobsen, G., additional, Jaervinen, A., additional, Jalalvand, A., additional, Janhunen, J., additional, Jardin, S., additional, Jarleblad, H., additional, Jeon, Y., additional, Ji, H., additional, Jian, X., additional, Joffrin, E., additional, Johansen, A., additional, Johnson, C., additional, Johnson, T., additional, Jones, C., additional, Joseph, I., additional, Jubas, D., additional, Junge, B., additional, Kalb, W., additional, Kalling, R., additional, Kamath, C., additional, Kang, J., additional, Kaplan, D., additional, Kaptanoglu, A., additional, Kasdorf, S., additional, Kates-Harbeck, J., additional, Kazantzidis, P., additional, Kellman, A., additional, Kellman, D., additional, Kessel, C., additional, Khumthong, K., additional, Kim, E., additional, Kim, H., additional, Kim, J., additional, Kim, S., additional, Kim, K., additional, Kim, C., additional, Kimura, W., additional, King, M., additional, King, J., additional, Kinsey, J., additional, Kirk, A., additional, Kiyan, B., additional, Kleiner, A., additional, Klevarova, V., additional, Knapp, R., additional, Knolker, M., additional, Ko, W., additional, Kobayashi, T., additional, Koch, E., additional, Kochan, M., additional, Koel, B., additional, Koepke, M., additional, Kohn, A., additional, Kolasinski, R., additional, Kolemen, E., additional, Kostadinova, E., additional, Kostuk, M., additional, Kramer, G., additional, Kriete, D., additional, Kripner, L., additional, Kubota, S., additional, Kulchar, J., additional, Kwon, K., additional, La Haye, R., additional, Laggner, F., additional, Lan, H., additional, Lantsov, R., additional, Lao, L., additional, Lasa Esquisabel, A., additional, Lasnier, C., additional, Lau, C., additional, Leard, B., additional, Lee, J., additional, Lee, R., additional, Lee, M., additional, Lee, Y., additional, Lee, C., additional, Lee, S., additional, Lehnen, M., additional, Leonard, A., additional, Leppink, E., additional, Lesher, M., additional, Lestz, J., additional, Leuer, J., additional, Leuthold, N., additional, Li, X., additional, Li, K., additional, Li, E., additional, Li, G., additional, Li, L., additional, Li, Z., additional, Li, J., additional, Li, Y., additional, Lin, Z., additional, Lin, D., additional, Liu, X., additional, Liu, J., additional, Liu, Y., additional, Liu, T., additional, Liu, C., additional, Liu, Z., additional, Liu, D., additional, Liu, A., additional, Loarte-Prieto, A., additional, Lodestro, L., additional, Logan, N., additional, Lohr, J., additional, Lombardo, B., additional, Lore, J., additional, Luan, Q., additional, Luce, T., additional, Luda Di Cortemiglia, T., additional, Luhmann, N., additional, Lunsford, R., additional, Luo, Z., additional, Lvovskiy, A., additional, Lyons, B., additional, Ma, X., additional, Madruga, M., additional, Madsen, B., additional, Maggi, C., additional, Maheshwari, K., additional, Mail, A., additional, Mailloux, J., additional, Maingi, R., additional, Major, M., additional, Makowski, M., additional, Manchanda, R., additional, Marini, C., additional, Marinoni, A., additional, Maris, A., additional, Markovic, T., additional, Marrelli, L., additional, Martin, E., additional, Mateja, J., additional, Matsunaga, G., additional, Maurizio, R., additional, Mauzey, P., additional, Mauzey, D., additional, Mcardle, G., additional, Mcclenaghan, J., additional, Mccollam, K., additional, Mcdevitt, C., additional, Mckay, K., additional, Mckee, G., additional, Mclean, A., additional, Mehta, V., additional, Meier, E., additional, Menard, J., additional, Meneghini, O., additional, Merlo, G., additional, Messer, S., additional, Meyer, W., additional, Michael, C., additional, Michoski, C., additional, Milne, P., additional, Minet, G., additional, Misleh, A., additional, Mitrishkin, Y., additional, Moeller, C., additional, Montes, K., additional, Morales, M., additional, Mordijck, S., additional, Moreau, D., additional, Morosohk, S., additional, Morris, P., additional, Morton, L., additional, Moser, A., additional, Moyer, R., additional, Moynihan, C., additional, Mrazkova, T., additional, Mueller, D., additional, Munaretto, S., additional, Munoz Burgos, J., additional, Murphy, C., additional, Murphy, K., additional, Muscatello, C., additional, Myers, C., additional, Nagy, A., additional, Nandipati, G., additional, Navarro, M., additional, Nave, F., additional, Navratil, G., additional, Nazikian, R., additional, Neff, A., additional, Neilson, G., additional, Neiser, T., additional, Neiswanger, W., additional, Nelson, D., additional, Nelson, A., additional, Nespoli, F., additional, Nguyen, R., additional, Nguyen, L., additional, Nguyen, X., additional, Nichols, J., additional, Nocente, M., additional, Nogami, S., additional, Noraky, S., additional, Norausky, N., additional, Nornberg, M., additional, Nygren, R., additional, Odstrcil, T., additional, Ogas, D., additional, Ogorman, T., additional, Ohdachi, S., additional, Ohtani, Y., additional, Okabayashi, M., additional, Okamoto, M., additional, Olavson, L., additional, Olofsson, E., additional, Omullane, M., additional, Oneill, R., additional, Orlov, D., additional, Orvis, W., additional, Osborne, T., additional, Pace, D., additional, Paganini Canal, G., additional, Pajares Martinez, A., additional, Palacios, L., additional, Pan, C., additional, Pan, Q., additional, Pandit, R., additional, Pandya, M., additional, Pankin, A., additional, Park, Y., additional, Park, J., additional, Parker, S., additional, Parks, P., additional, Parsons, M., additional, Patel, B., additional, Pawley, C., additional, Paz-Soldan, C., additional, Peebles, W., additional, Pelton, S., additional, Perillo, R., additional, Petty, C., additional, Peysson, Y., additional, Pierce, D., additional, Pigarov, A., additional, Pigatto, L., additional, Piglowski, D., additional, Pinches, S., additional, Pinsker, R., additional, Piovesan, P., additional, Piper, N., additional, Pironti, A., additional, Pitts, R., additional, Pizzo, J., additional, Plank, U., additional, Podesta, M., additional, Poli, E., additional, Poli, F., additional, Ponce, D., additional, Popovic, Z., additional, Porkolab, M., additional, Porter, G., additional, Powers, C., additional, Powers, S., additional, Prater, R., additional, Pratt, Q., additional, Pusztai, I., additional, Qian, J., additional, Qin, X., additional, Ra, O., additional, Rafiq, T., additional, Raines, T., additional, Raman, R., additional, Rauch, J., additional, Raymond, A., additional, Rea, C., additional, Reich, M., additional, Reiman, A., additional, Reinhold, S., additional, Reinke, M., additional, Reksoatmodjo, R., additional, Ren, Q., additional, Ren, Y., additional, Ren, J., additional, Rensink, M., additional, Renteria, J., additional, Rhodes, T., additional, Rice, J., additional, Roberts, R., additional, Robinson, J., additional, Rodriguez Fernandez, P., additional, Rognlien, T., additional, Rosenthal, A., additional, Rosiello, S., additional, Rost, J., additional, Roveto, J., additional, Rowan, W., additional, Rozenblat, R., additional, Ruane, J., additional, Rudakov, D., additional, Ruiz Ruiz, J., additional, Rupani, R., additional, Saarelma, S., additional, Sabbagh, S., additional, Sachdev, J., additional, Saenz, J., additional, Saib, S., additional, Salewski, M., additional, Salmi, A., additional, Sammuli, B., additional, Samuell, C., additional, Sandorfi, A., additional, Sang, C., additional, Sarff, J., additional, Sauter, O., additional, Schaubel, K., additional, Schmitz, L., additional, Schmitz, O., additional, Schneider, J., additional, Schroeder, P., additional, Schultz, K., additional, Schuster, E., additional, Schwartz, J., additional, Sciortino, F., additional, Scotti, F., additional, Scoville, J., additional, Seltzman, A., additional, Seol, S., additional, Sfiligoi, I., additional, Shafer, M., additional, Sharapov, S., additional, Shen, H., additional, Sheng, Z., additional, Shepard, T., additional, Shi, S., additional, Shibata, Y., additional, Shin, G., additional, Shiraki, D., additional, Shousha, R., additional, Si, H., additional, Simmerling, P., additional, Sinclair, G., additional, Sinha, J., additional, Sinha, P., additional, Sips, G., additional, Sizyuk, T., additional, Skinner, C., additional, Sladkomedova, A., additional, Slendebroek, T., additional, Slief, J., additional, Smirnov, R., additional, Smith, J., additional, Smith, S., additional, Smith, D., additional, Snipes, J., additional, Snoep, G., additional, Snyder, A., additional, Snyder, P., additional, Solano, E., additional, Solomon, W., additional, Song, J., additional, Sontag, A., additional, Soukhanovskii, V., additional, Spendlove, J., additional, Spong, D., additional, Squire, J., additional, Srinivasan, C., additional, Stacey, W., additional, Staebler, G., additional, Stagner, L., additional, Stange, T., additional, Stangeby, P., additional, Stefan, R., additional, Stemprok, R., additional, Stephan, D., additional, Stillerman, J., additional, Stoltzfus-Dueck, T., additional, Stonecipher, W., additional, Storment, S., additional, Strait, E., additional, Su, D., additional, Sugiyama, L., additional, Sun, Y., additional, Sun, P., additional, Sun, Z., additional, Sun, A., additional, Sundstrom, D., additional, Sung, C., additional, Sungcoco, J., additional, Suttrop, W., additional, Suzuki, Y., additional, Suzuki, T., additional, Svyatkovskiy, A., additional, Swee, C., additional, Sweeney, R., additional, Sweetnam, C., additional, Szepesi, G., additional, Takechi, M., additional, Tala, T., additional, Tanaka, K., additional, Tang, X., additional, Tang, S., additional, Tao, Y., additional, Tao, R., additional, Taussig, D., additional, Taylor, T., additional, Teixeira, K., additional, Teo, K., additional, Theodorsen, A., additional, Thomas, D., additional, Thome, K., additional, Thorman, A., additional, Thornton, A., additional, Ti, A., additional, Tillack, M., additional, Timchenko, N., additional, Tinguely, R., additional, Tompkins, R., additional, Tooker, J., additional, Torrezan De Sousa, A., additional, Trevisan, G., additional, Tripathi, S., additional, Trujillo Ochoa, A., additional, Truong, D., additional, Tsui, C., additional, Turco, F., additional, Turnbull, A., additional, Umansky, M., additional, Unterberg, E., additional, Vaezi, P., additional, Vail, P., additional, Valdez, J., additional, Valkis, W., additional, Van Compernolle, B., additional, Van Galen, J., additional, Van Kampen, R., additional, Van Zeeland, M., additional, Verdoolaege, G., additional, Vianello, N., additional, Victor, B., additional, Viezzer, E., additional, Vincena, S., additional, Wade, M., additional, Waelbroeck, F., additional, Wai, J., additional, Wakatsuki, T., additional, Walker, M., additional, Wallace, G., additional, Waltz, R., additional, Wampler, W., additional, Wang, L., additional, Wang, H., additional, Wang, Y., additional, Wang, Z., additional, Wang, G., additional, Ward, S., additional, Watkins, M., additional, Watkins, J., additional, Wehner, W., additional, Wei, Y., additional, Weiland, M., additional, Weisberg, D., additional, Welander, A., additional, White, A., additional, White, R., additional, Wiesen, S., additional, Wilcox, R., additional, Wilks, T., additional, Willensdorfer, M., additional, Wilson, H., additional, Wingen, A., additional, Wolde, M., additional, Wolff, M., additional, Woller, K., additional, Wolz, A., additional, Wong, H., additional, Woodruff, S., additional, Wu, M., additional, Wu, Y., additional, Wukitch, S., additional, Wurden, G., additional, Xiao, W., additional, Xie, R., additional, Xing, Z., additional, Xu, X., additional, Xu, C., additional, Xu, G., additional, Yan, Z., additional, Yang, X., additional, Yang, S., additional, Yokoyama, T., additional, Yoneda, R., additional, Yoshida, M., additional, You, K., additional, Younkin, T., additional, Yu, J., additional, Yu, M., additional, Yu, G., additional, Yuan, Q., additional, Zaidenberg, L., additional, Zakharov, L., additional, Zamengo, A., additional, Zamperini, S., additional, Zarnstorff, M., additional, Zeger, E., additional, Zeller, K., additional, Zeng, L., additional, Zerbini, M., additional, Zhang, L., additional, Zhang, X., additional, Zhang, R., additional, Zhang, B., additional, Zhang, J., additional, Zhao, L., additional, Zhao, B., additional, Zheng, Y., additional, Zheng, L., additional, Zhu, B., additional, Zhu, J., additional, Zhu, Y., additional, Zsutty, M., additional, and Zuin, M., additional

Published
2022
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160. Homeostatic Shrinkage of Dendritic Spines Requires Melatonin Type 3 Receptor Activation During Sleep

Author

Shiyin Li, Xin Li, Minmin Lu, Quanhui Chen, Di Yao, Xiaoqian Yu, Zhen Li, Woo‐ping Ge, Na Wang, Jiehua Jin, Yaling Wang, Yixiang Liao, Fenlan Luo, Jie Yan, Xuedan Chen, Chenggang Jiang, Faguo Yue, Dong Gao, Xiangdong Tang, Hong Guo, Yanjiang Wang, Xiaowei Chen, Jianxia Xia, Min Xu, Shuancheng Ren, Chao He, and Zhian Hu

Subjects
medial entorhinal cortex, melatonin, sleep, spatial memory, Science
Abstract

Abstract High‐frequency oscillatory activity in cognition‐related neural circuits during wakefulness consistently induces the growth of dendritic spines and axonal terminals. Although these structural changes are essential for cognitive functions, it is hypothesized that if these newly expanded structures fail to establish functional connections, they may become superfluous. Sleep is believed to facilitate the reduction of such redundant structures to maintain neural homeostasis. However, the mechanisms underlying this pruning process during sleep remain poorly understood. In this study, that melatonin type 3 receptors (MT3Rs) are selectively expressed in the stellate neurons of the medial entorhinal cortex (MEC) is demonstrated, an area where high melatonin levels are detected during sleep. Activation of MT3Rs during sleep initiates the shrinkage of dendritic spines in stellate neurons by downregulating neural network activity and dephosphorylating synaptic proteins in the MEC. This process is disrupted when MT3R expression is knocked down or when MT3Rs are blocked during sleep. Notably, interference with MT3Rs in the MEC during sleep impairs the acquisition of spatial memory but does not affect object memory acquisition following sleep. These findings reveal novel molecular mechanisms involving melatonin and MT3Rs in the regulation of dendritic spine shrinkage during sleep, which is crucial for the acquisition and consolidation of spatial memory.

Published
2024
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161. Erratum to 'Probing high-momentum component in nucleon momentum distribution by neutron-proton bremsstrahlung γ-rays in heavy ion reactions' [Phys. Lett. B 850 (2024) 138514]

Author

Yuhao Qin, Qinglin Niu, Dong Guo, Sheng Xiao, Baiting Tian, Yijie Wang, Zhi Qin, Xinyue Diao, Fenhai Guan, Dawei Si, Boyuan Zhang, Yaopeng Zhang, Xianglun Wei, Herun Yang, Peng Ma, Haichuan Zou, Tianli Qiu, Xinjie Huang, Rongjiang Hu, Limin Duan, Hooi Jin Ong, Yanyun Yang, Shiwei Xu, Kang Wang, Zhen Bai, Junbing Ma, Fangfang Duan, Guo Yang, Qiang Hu, Hongwei Wang, Baohua Sun, Sergei P. Maydanyuk, Chang Xu, and Zhigang Xiao

Subjects
Physics, QC1-999
Published
2024
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162. Design of a nanozyme-based magnetic nanoplatform to enhance photodynamic therapy and immunotherapy

Author

Chen Bai, Jiajing Liu, Luyao Bai, Dapeng Yao, Xiaofeng Li, Haoran Zhang, and Dong Guo

Subjects
Nanozyme, Photodynamic therapy, Tumor microenvironment, Immunotherapy, Dual-mode tomography, Therapeutics. Pharmacology, RM1-950
Abstract

The tumor microenvironment, particularly the hypoxic property and glutathione (GSH) overexpression, substantially inhibits the efficacy of cancer therapy. In this article, we present the design of a magnetic nanoplatform (MNPT) comprised of a photosensitizer (Ce6) and an iron oxide (Fe3O4)/manganese oxide (MnO2) composite nanozyme. Reactive oxygen species (ROS), such as singlet oxygen (1O2) radicals produced by light irradiation and hydroxyl radicals (·OH) produced by catalysis, are therapeutic species. These therapeutic substances stimulate cell apoptosis by increasing oxidative stress. This apoptosis then triggers the immunological response, which combines photodynamic therapy and T-cell-mediated immunotherapy to treat cancer. Furthermore, MNPT can be utilized as a contrast agent in magnetic resonance and fluorescence dual-modality imaging to give real-time tracking and feedback on treatment.

Published
2024
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163. Anisotropic optical and magneto-optical properties of antiferromagnetic Weyl semimetal Mn3Sn epitaxial thin films

Author

Dong Gao, Ting Yang, Fu Tang, Jiejun Su, Weihao Yang, Dengfu Deng, Yunfei Xie, Jun Qin, Xiao Liang, and Lei Bi

Subjects
Biotechnology, TP248.13-248.65, Physics, QC1-999
Abstract

Antiferromagnetic Weyl semimetal Mn3Sn exhibiting strong magneto-optical Kerr effect (MOKE) due to non-zero Berry curvature is attractive for spintronic and photonic device applications. Despite many reports on the anisotropic anomalous Hall effect (AHE), so far, there have been few studies on its anisotropic optical properties. In this work, we experimentally characterized the anisotropic optical and magneto-optical (MO) properties of Mn3Sn(20)/MgO(110) and Mn3Sn(0001)/Al2O3(0001) epitaxial films using ellipsometry in the wavelength range from 300 to 1690 nm. By measuring the Mueller matrix of magnetized Mn3Sn, the anisotropic permittivity tensor is determined using the 4 × 4 transfer matrix method. Temperature dependent MOKE measurement confirmed the origin of the anisotropic MO effect to the non-zero Berry curvature of the chiral magnetic phase. The measured permittivity also agrees well with first-principles calculations. The anisotropic optical and MO properties determined in this work can be useful for Mn3Sn based spintronic device characterization and photonic device development.

Published
2024
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164. Effectiveness of a protein-supplemented very-low-calorie diet program for weight loss: a randomized controlled trial in South Korea

Author

Eunbyul Cho, Sohye Kim, Hwa Jung Kim, Belong Cho, Jin Ho Park, Hyuktae Kwon, Ju Young Kim, Yumi Go, Dong Gyun Kang, Eunyoung Shin, Sumi Lee, Siye Gil, Hyerim Kim, Jihyun Ahn, Joo Young Kim, WonJoo Jung, and Eunyoung Go

Subjects
high-protein diet, very-low-calorie diet, meal replacement, obesity, waist circumference, Nutrition. Foods and food supply, TX341-641
Abstract

IntroductionWeight-loss strategies through meal replacements are effective and sustainable options. However, few studies have assessed their effects on weight loss including body composition through protein-supplemented meal replacements targeting the Asian population, including Koreans. This study aimed to assess the effectiveness and safety of a protein-supplemented very-low-calorie diet (PSVLCD) for weight reduction and changes in body composition in individuals with obesity over a 12-month long-term period.MethodsIn total, 106 participants with obesity were randomly assigned to a PSVLCD or control group (food-based calorie-restricted diet). Body weight, waist circumference, body composition, and blood marker levels were measured throughout the study. Statistical analyses were performed to compare outcomes between the groups.ResultsAmong the 106 participants, 84 completed the 12-month follow-up. Intention-to-treat analysis showed that the mean weight loss from baseline to 12 months was −6.86 kg (8.21% of baseline weight) in the PSVLCD group and − 4.66 kg (5.47% of initial body weight) in the control group; the difference was −2.20 kg with a marginally significant interval (95% confidence interval [CI], −4.90; 0.50). Waist circumference (−8.35 cm vs. -4.85 cm; mean difference, −3.49 cm; 95% CI, −6.48 to −0.50) and visceral fat area (−28.28 cm2 vs. −13.26 cm2; mean difference, −15.03cm2; 95% CI, −29.01 to −1.04) also significantly decreased in the PSVLCD group at 12 months.DiscussionThe PSVLCD group demonstrated a substantial initial reduction in waist circumference that was sustained over the study period, alongside a marginally significant decrease in weight. These findings suggest that a protein-supplemented very-low-calorie diet may be an effective strategy for long-term weight management and body composition improvement in individuals with obesity.Clinical trial registrationClinicalTrials.gov, identififer NCT04597788.

Published
2024
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165. Dynamic properties of CO2-cured foam concrete at different loading rates: Effect of the foam admixtures and addition of polypropylene fiber

Author

Yunlin Liu, Shangwei Huo, Jiali Fu, Tingbo Shi, and Dong Guo

Subjects
foam concrete, CO2-curing, polypropylene fiber, SHPB, dynamic impact, Technology
Abstract

This paper investigated the dynamic mechanical properties of CO2-cured foam concrete under varying conditions, focusing on the effects of foam admixture and fiber reinforcement. The study tends to enrich the knowledge regarding the performance of CO2-cured foam concrete under different loading rates, especially in relation to density and matrix strength. The foam admixture of the specimens ranges from 26% to 55%, achieving density from 600 kg/m3 to 1,000 kg/m3. The specimens were loaded at strain rates from 80 s-1 to 398 s-1. Experimental results revealed the dynamic elastic modulus, dynamic compressive strength, and Dynamic Increase Factor (DIF) showed a strong correlation with the foam admixture and density. In addition, the incorporation of polypropylene (PP) fibers effectively improved the mechanical behavior of the foam concrete, achieving up to a 17% increase in dynamic compressive strength. This comprehensive analysis highlights the critical role of foam admixture and fiber reinforcement in determining the dynamic properties of CO2-cured foam concrete and provides valuable insights for optimizing the dynamic performance of foam concrete in various construction applications.

Published
2024
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168. Defect engineering in lanthanide doped luminescent materials

Author

Zhou, J, Zheng, G, Liu, X, Dong, G, and Qiu, J

Subjects
0302 Inorganic Chemistry, 0306 Physical Chemistry (incl. Structural), 0399 Other Chemical Sciences, General Chemistry
Abstract

Lanthanides doped luminescent materials (LLMs) have recently gained considerable attention in the areas of bioimaging, sensing, display, and lasers, benefitting from the intriguing optical characters of lanthanides. In LLMs, defect creates intermediate energy levels within the bandgap, which tailors the excited-state dynamics of lanthanides in photophysics and manipulates the spectroscopic characteristics of the lanthanides with much enhanced precision, and thus defect engineering could be a powerful tool in designing LLMs. In this review, we first discuss the creation and characterization of defects in LLMs, which are especially facilitated by the rapid development in nanofabrication, the state-of-the-art instrumental techniques and computation methods. This advances have pushed the manipulation, understanding and utilization of defects in LLMs to a whole new-level and the tailoring of LLMs with desinged performance to meet the requirements of specific application has been dramatically improved in recent years. We then review the emerging applications of the defect-involved LLMs ranging from colour displays, energy utilization, radiation detection to biological applications. Finally, we envision future potential directions in the research of defect engineerin of LLMs and highlight the unsolved problems in this rapidly growing field.

Published
2021

175. Propionic acid induces apoptosis-like death in Escherichia coli O157

Author

Minji Kim and Dong G. Lee

Subjects
Apoptosis, General Medicine, Propionates, Escherichia coli O157, Reactive Oxygen Species, Applied Microbiology and Biotechnology
Abstract

Propionic acid (PPA), utilized in the manufacture of cellulose acetate propionate, is known to exhibit antimicrobial effects, but its mechanism in Escherichia coli O157 is still unknown. In general, antimicrobial activity is associated with reactive oxygen species (ROS), but ROS generation is not observed under PPA treatment. In addition to ROS, experiments were conducted to observe changes in trehalose and ion balance to discover factors that may affect the cell proliferation. Bacteria use trehalose, a sugar used for stabilization due to stress factors, which contradicts PPA concentration. Discrepancy in homeostasis follows as a result of ion imbalance. PPA causes interruption in bacterial internal stability in a dose-dependent manner. Membrane damage by ion imbalance occurs due to the binding ability of ionized PPA and divalent ions, which induce membrane depolarization, leading to a reduction in cell viability. Considering the lethal impact of membrane depolarization on cell death in bacteria, DNA fragmentation and phosphatidylserine exposure in apoptosis are confirmed. Due to severe damage in DNA, the activation of caspase-like protein is observed. Apoptosis-like death (ALD), a novel programmed cell death in bacteria, occurs eventually. In conclusion, ALD in E. coli O157 is induced via the contribution of homeostasis disruption in a ROS-independent manner.

Published
2021

178. Barrier Properties of Polyhydroxybutyrate/Ethyl Cellulose-blend-coated Paper through the Incorporation of Organo-modified Nanoclay as a Coating Component

Author

Yong Ju Lee, Dong Gun Lim, Ji Eun Cha, Do Young Lee, Tai-Ju Lee, and Hyoung Jin Kim

Subjects
polyhydroxybutyrate, ethyl cellulose, nanoclay, nano-organo bentonite, organo-modification, biodegradable polymers, barrier coating, Biotechnology, TP248.13-248.65
Abstract

A sodium bentonite product (nanoclay) was added to a polyhydroxybutyrate/ ethyl cellulose (PHB/EC) blend coating agent, and the impact of the nanoclay content on the properties of the coated paper was investigated. The organically treated nanoclay exhibited enhanced compatibility with the PHB/EC blend, ensuring uniform dispersion within the coating layer and improving the barrier properties of the coated paper. The mechanical properties of the PHB/EC blend-coated paper with nanoclay demonstrated ductile behavior, reducing the tensile strength and increasing the elongation. However, at higher nanoclay loadings, specifically up to 25%, aggregation among nanoclay particles occurred. This hindered the enhancement of barrier properties, thereby decreasing the degree of elongation. Incorporating nanoclay as a filler in the PHB/EC blend at suitable levels showed potential for further enhancing the barrier properties and ensuring economic feasibility in the production of packaging paper.

Published
2024

179. Quantum chemical calculation of coal spontaneous combustion mechanism promoted by transition metal ions

Author

Fusheng WANG, Wei SUN, Yu ZHANG, Chaoyang ZHANG, Dong GAO, and Jiankun ZHUO

Subjects
transition metal ions, coal spontaneous combustion, quantum chemistry, activation energy, free energy, Geology, QE1-996.5, Mining engineering. Metallurgy, TN1-997
Abstract

In order to study the effect of typical transition metal ions on coal spontaneous combustion under low temperature oxidation conditions, the transition metal ions of lignite (HM), gas coal (QM) and fertilizer coal (FM) were determined, and Fe (Ⅲ), Mn (Ⅲ) and Cu (Ⅱ), which are abundant in transition metal ions and have strong oxidation, were selected as the research objects. The charge distribution, frontier orbitals and Laplacian bond levels were analyzed by the quantum chemistry calculation method, and the existence of active sites was proved. Two reaction processes of Ar—CH2—CH3 to Ar—CO—CH3 with or without transition metal ions were investigated, and the thermodynamic parameters were obtained by model optimization, transition state calculation and IRC verification. The calculation results show that the activation energy barrier is 164.18 kJ/mol without transition metal ion and 158.72 kJ/mol with transition metal ion. The effect of transition metal ion on the total reaction rate is not significant. With the participation of Fe (Ⅲ), Mn (Ⅲ) and Cu (Ⅱ), the total heat releases of the reaction are 1535.52, 1834.97 and 365.93 kJ/mol, respectively, which are higher than the heat release from the oxidation of aliphatic hydrocarbons by oxygen molecules (319.93 kJ/mol). The free energy barriers of C—H in oxidized aliphatic hydrocarbons are 42.79, 4.30 and 117.29 kJ/mol, respectively, which are all lower than the activation energies of C—H oxidation by oxygen molecules (146.38 kJ/mol). The order of C—H oxidation capacity of transition metal ions from high to low is Mn (Ⅲ), Fe (Ⅲ) and Cu (Ⅱ). During the reaction process, the formation of ·OH and H+ is accompanied by further reaction with the coal structure to accelerate the spontaneous combustion process of coal. In order to verify the accuracy of the simulation results, the time and concentration of CO gas products in four different coal samples were measured by temperature programmed gas chromatography. It was found that the temperature points of CO gas products in four coal samples were similar. The coal samples with manganese ion added produced CO gas products at 90 ℃, while the other three coal samples produced CO gas products at 100 ℃. The concentration of CO gas products from large to small is Mn (Ⅲ), Fe (Ⅲ), Cu (Ⅱ) and raw coal sample, which is consistent with the calculated results. With the increase of temperature, the effect of Mn (Ⅲ) on increasing the rate of CO production gradually weakens, and the effect of iron and copper ions on catalytic coal spontaneous combustion is gradually significant. The experimental results have a certain correlation with the simulation results. Compared with oxygen molecules, transition metal ions in coal are more likely to oxidize C—H, which not only causes the free radical chain reaction to occur earlier, but also increases the heat release of the reaction and the production of ·OH and H+, thus promoting spontaneous combustion of coal. This has reference significance for the mechanism of spontaneous combustion of transition metal catalyzed coal.

Published
2024
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180. NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21

Author

Dong Guo, Shuo Zhou, Ruixue Liu, Weinan Yao, Shuguang Li, Xueyuan Zhang, Wenbin Shen, and Shuchai Zhu

Subjects
NEK2, Radioresistance, Autophagy, TRIM21, Esophageal squamous cell carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
Abstract

Abstract Background Radiotherapy (RT) has been identified as a vital treatment for esophageal squamous cell carcinoma (ESCC), while the development of radioresistance remains a major obstacle in ESCC management. The aim of this study was to investigate the effect of NIMA-related kinase 2 (NEK2) on radioresistance in ESCC cells and to reveal potential molecular mechanisms. Methods Human esophageal epithelial cells (HEEC) and human ESCC cell lines were obtained from the Research Center of the Fourth Hospital of Hebei Medical University (Shijiazhuang, China). Cell Counting Kit-8 (CCK-8) and flow cytometry assays were applied to assess the proliferation ability, cell cycle, apoptosis rates, and ROS production of ESCC cells. The colony-forming assay was used to estimate the effect of NEK2 on radiosensitivity. Autophagy was investigated by western blotting analysis, GFP-mRFP-LC3 fluorescence assay, and transmission electron microscopy (TEM). Results In the present study, our results showed that NEK2 was associated with radioresistance, cell cycle arrest, apoptosis, ROS production, and survival of ESCC. NEK2 knockdown could significantly inhibit growth while enhancing radiosensitivity and ROS production in ESCC cells. Interestingly, NEK2 knockdown inhibited ESCC cell autophagy and reduced autophagic flux, ultimately reversing NEK2-induced radioresistance. Mechanistically, NEK2 bound to and regulated the stability of tripartite motif-containing protein 21 (TRIM21). The accumulation of NEK2-induced light chain 3 beta 2 (LC3B II) can be reversed by the knockdown of TRIM21. Conclusion These results demonstrated that NEK2 activated autophagy through TRIM21, which may provide a promising therapeutic strategy for elucidating NEK2-mediated radioresistance in ESCC.

Published
2024
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181. Toughness behavior and deformation mechanisms in FCC-based Fe45Co30Cr10V10Ni5-xMnx high-entropy alloys: Insights from instrumented Charpy impact tests

Author

Yong Hee Jo, Yeon Taek Choi, Dong Geun Kim, Jeongho Han, and Sukjin Lee

Subjects
High-entropy alloy (HEA), Instrumented Charpy impact test, Transformation-induced plasticity (TRIP), Slip-line field, Initiation of crack propagation, Mining engineering. Metallurgy, TN1-997
Abstract

This study investigated toughness properties of FCC-based Fe45Co30Cr10V10Ni5-xMnx high entropy alloys (HEAs). Ductile-dimpled rupture mode in all alloys and test temperatures complicated precise explanations on Charpy impact energy, but the instrumented Charpy test provided a breakdown of total energy (ET) into initiation energy (EI) and propagation energy (EP), offering critical insights into Mn-content- and temperature-related energy variations. Pmax and TP, reflecting maximum flow stress and time, respectively, until initiation of crack propagation from the notch tip, involved a transition of deformation mechanisms from slip to TWIP, then to BCC-TRIP, thereby inducing increased strain hardening and delaying plastic instability at the notch tip. At 25 °C, an increase in Mn content prompted a transition in deformation behavior from slip to TWIP and subsequently to BCC-TRIP, correlating well with increased Pmax and TP and consequently ET due to enhanced strain hardenability. At −196 °C, predominant BCC-TRIP activity in all alloys led to increased formation of BCC martensite, intensifying strain hardening and requiring higher Pmax for crack initiation than at 25 °C. Due to minimal slip line field formation associated with reduced plastic deformation, however, cracks initiated directly from the notch-tip center, representing fast initiation of crack propagation and consequently reduction in EI and ET. Thus, utilizing parameters from instrumented Charpy tests, including Pmax, TP, EI, EP, and ET, provided insights into fracture phenomena and their interrelations in the present HEAs.

Published
2024
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182. Cross-Domain Unmanned Cluster Combat Supported by Satellite Internet

Author

Mo LI, Dong GUO, Donghong ZHOU, Guantao DONG, Dongyu LI, Hongbing CHU, and Zhigang SHANG

Subjects
satellite internet, cross-domain, unmanned cluster, Naval architecture. Shipbuilding. Marine engineering, VM1-989
Abstract

Cross-domain unmanned cluster is a disruptive new combat mode in the future, and its combat effectiveness is greatly affected by communication networking capabilities. In recent years, satellite Internet, with its technological advantages of wide coverage, low latency, high bandwidth, and low cost, has developed rapidly in the world, and it is the key to further developing the cross-domain unmanned cluster combat mode. In view of the development trend and practical needs of the future unmanned undersea system, the development and technical advantages of satellite Internet, as well as the concept of cross-domain unmanned cluster combat were introduced. The advantages of cross-domain unmanned cluster combat supported by satellite Internet were deeply analyzed. The air-sea cross-domain unmanned cluster combat network was proposed by combining satellite Internet technology and unmanned clusters in airspace, sea surface, and undersea combat domains. In addition, a comprehensive analysis of the technical architecture was given, providing a reference for future research on cross-domain unmanned cluster combat.

Published
2024
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183. Comparison of the efficacy of the convex side short fusion combined with concave side single growing rod technique and the traditional bilateral growing rod technique in the treatment of early onset scoliosis

Author

Weiwei Zhu, Xuejun Zhang, Jun Cao, Baihui Zhang, Wenhao Chen, Yunsong Bai, Dong Guo, and Ziming Yao

Subjects
Early Onset Scoliosis, Growing Rod Technique, Efficacy, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Objectives The application of a growing rod technique can retain the growth and development potential of the spine and thorax while controlling the progression of scoliosis deformity. Theoretically, convex side short fusion combined with a concave side single growing rod technique can significantly reduce the asymmetric growth of the spine in the vertex region in most patients. However, the final clinical outcome of various techniques is yet to be clearly determined and compared between studies. Therefore, we compared the efficacy of these two growing rod techniques in treating early onset scoliosis. Methods In a retrospective study of 152 EOS patients seen between 2013.1 and 2019.12, 36 cases of EOS patients were selected for inclusion. Among the 36 cases, 11 cases were treated with convex side short fusion combined with a concave side single growing rod technique, group (A) The remaining 25 cases were treated with traditional bilateral growing rod technique, group (B) Age, gender, etiology, follow-up time, Cobb angle of main curve, T1-S1 height, coronal trunk shift, sagittal vertical axis (SVA), Cobb angle of thoracic kyphosis at last follow-up, and Cobb angle at proximal junction kyphosis of the first and last post-operation follow-up were recorded. In addition, internal fixation related complications, infection, nervous system complications were recorded as well. Results There was no statistically significant difference between group A and group B in preoperative age, Cobb angle of main curve, coronal trunk shift, T1-S1 height, SVA, Cobb angle of thoracic kyphosis (p > 0.05). However, at the last follow-up (Group A, mean 4.4 ± 1.01 years; Group B, mean 3.6 ± 0.01 years) the Cobb angle of the main curve was less and T1-S1 height greater in group A compared with group B (p 0.05). There was no statistically significant difference in the coronal imbalance ratio, thoracic kyphosis abnormality ratio, or the occurrence PJK ratio between group A and group B at the last follow-up (p > 0.05), but the sagittal imbalance ratio and internal fixation abnormality ratio were higher in group A than in the group B (p

Published
2024
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184. Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers

Author

Min Pyeong Kim, Swatilekha Kayal, Chiwon Hwang, Jonghoon Bae, Hyunseok Kim, Dong Gyu Hwang, Min Ho Jeon, Jeong Kon Seo, Dowon Ahn, Wonjoo Lee, Sangwon Seo, Joong-Hyun Chun, Youngchang Yu, and Sung You Hong

Subjects
Science
Abstract

Abstract The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated. The oligosulfate sequences are determined by high resolution mass spectrometry of the hydrolyzed fragments, and polysulfate periodic copolymers are synthesized by using oligomeric bisfluorosulfates in a bi-directional fashion. The synthetic utility of this iterative ligation is demonstrated by preparing crosslinked network polymers as synthetic adhesive materials.

Published
2024
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185. Controlled condensation by liquid contact-induced adaptations of molecular conformations in self-assembled monolayers

Author

Guoying Bai, Haiyan Zhang, Dong Gao, Houguo Fei, Cunlan Guo, Mingxia Ren, and Yufeng Liu

Subjects
Science
Abstract

Abstract Surface condensation control strategies are crucial but commonly require relatively tedious, time-consuming, and expensive techniques for surface-chemical and topographical engineering. Here we report a strategy to alter surface condensation behavior without resorting to any molecule-type or topographical transmutations. After ultrafast contact of liquids with and removal from surfaces, the condensation rate and density of water droplets on the surfaces decrease, the extent of which is positively correlated with the polarity of the liquid and the duration of contact. The liquid contact-induced condensation rate/density decrease (LCICD) can be attributed to the decrease of nucleation site density resulted from the liquid contact-induced adaption of surface molecular conformation. Based on this, we find that LCICD is applicable to various surfaces, on condition that there are flexible segments capable of shielding at least part of nucleation sites through changing the conformation under liquid contact induction. Leveraging the LCICD effect, we achieve erasable information storage on diverse substrates. Furthermore, our strategy holds promise for controlling condensation of other substances since LCICD is not specific to the water condensation process.

Published
2024
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186. Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity

Author

Jihoon G. Yoon, Dong Geon Jang, Sung-Gyu Cho, Chaeyoung Lee, Shin Hye Noh, Soo Kyung Seo, Jung Woo Yu, Hyeon Woo Chung, KyeoRe Han, Soon Sung Kwon, Dai Hoon Han, Jaeseong Oh, In-Jin Jang, Sang-Hoon Kim, Young-Koo Jee, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Chul Hoon Kim, Jae Myun Lee, Sang-Heon Kim, and Min Goo Lee

Subjects
Medicine, Biochemistry, QD415-436
Abstract

Abstract Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that may increase the susceptibility of individuals to AT-DILI and to examine genetic interactions that may lead to isoniazid (INH)-induced hepatotoxicity. We performed a targeted sequencing analysis of 380 pharmacogenes in a discovery cohort of 112 patients (35 AT-DILI patients and 77 controls) receiving AT treatment for active tuberculosis. Pharmacogenome-wide association analysis was also conducted using 1048 population controls (Korea1K). NAT2 and ATP7B genotypes were analyzed in a replication cohort of 165 patients (37 AT-DILI patients and 128 controls) to validate the effects of both risk genotypes. NAT2 ultraslow acetylators (UAs) were found to have a greater risk of AT-DILI than other genotypes (odds ratio [OR] 5.6 [95% confidence interval; 2.5–13.2], P = 7.2 × 10−6). The presence of ATP7B gene 832R/R homozygosity (rs1061472) was found to co-occur with NAT2 UA in AT-DILI patients (P = 0.017) and to amplify the risk in NAT2 UA (OR 32.5 [4.5–1423], P = 7.5 × 10−6). In vitro experiments using human liver-derived cell lines (HepG2 and SNU387 cells) revealed toxic synergism between INH and Cu, which were strongly augmented in cells with defective NAT2 and ATP7B activity, leading to increased mitochondrial reactive oxygen species generation, mitochondrial dysfunction, DNA damage, and apoptosis. These findings link the co-occurrence of ATP7B and NAT2 genotypes to the risk of INH-induced hepatotoxicity, providing novel mechanistic insight into individual AT-DILI susceptibility. Yoon et al. showed that individuals who carry NAT2 UAs and ATP7B 832R/R genotypes are at increased risk of developing isoniazid hepatotoxicity, primarily due to the increased synergistic toxicity between isoniazid and copper, which exacerbates mitochondrial dysfunction-related apoptosis.

Published
2024
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187. Evaluating a combination treatment of NK cells and reovirus against bladder cancer cells using an in vitro assay to simulate intravesical therapy

Author

Yuree Lim, Jeehun Park, Joung Eun Lim, Minji Park, Seung Kwon Koh, Mijeong Lee, Sang-ki Kim, Seung-Hwan Lee, Ki-Hoon Song, Dong Guk Park, Hyun-Young Kim, Byong Chang Jeong, and Duck Cho

Subjects
Medicine, Science
Abstract

Abstract Intravesical treatment using either reovirus or natural killer (NK) cells serves as an efficient strategy for the treatment of bladder cancer cells (BCCs); however, corresponding monotherapies have often shown modest cytotoxicity. The potential of a locoregional combination using high-dose reovirus and NK cell therapy in an intravesical approach has not yet been studied. In this study, we evaluated the effectiveness of reoviruses and expanded NK cells (eNK) as potential strategies for the treatment of bladder cancer. The anti-tumor effects of mono-treatment with reovirus type 3 Dearing strain (RC402 and RP116) and in combination with interleukin (IL)-18/-21-pretreated eNK cells were investigated on BCC lines (5637, HT-1376, and 253J-BV) using intravesical therapy to simulate in vitro model. RP116 and IL-18/-21-pretreated eNK cells exhibited effective cytotoxicity against grade 1 carcinoma (5637 cells) when used alone, but not against HT-1376 (grade 2 carcinoma) and 253J-BV cells (derived from a metastatic site). Notably, combining RP116 with IL-18/-21-pretreated eNK cells displayed effective cytotoxicity against both HT-1376 and 253J-BV cells. Our findings underscore the potential of a combination therapy using reoviruses and NK cells as a promising strategy for treating bladder cancer.

Published
2024
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188. Asymmetric synthesis of P-stereogenic phosphindane oxides via kinetic resolution and their biological activity

Author

Long Yin, Jiajia Li, Changhui Wu, Haoran Zhang, Wenchao Zhao, Zhiyuan Fan, Mengxuan Liu, Siqi Zhang, Mengzhe Guo, Xiaowei Dou, and Dong Guo

Subjects
Science
Abstract

Abstract The importance of P-stereogenic heterocycles has been widely recognized with their extensive use as privileged chiral ligands and bioactive compounds. The catalytic asymmetric synthesis of P-stereogenic phosphindane derivatives, however, remains a challenging task. Herein, we report a catalytic kinetic resolution of phosphindole oxides via rhodium-catalyzed diastereo- and enantioselective conjugate addition to access enantiopure P-stereogenic phosphindane and phosphindole derivatives. This kinetic resolution method features high efficiency (s factor up to >1057), excellent stereoselectivities (all >20:1 dr, up to >99% ee), and a broad substrate scope. The obtained chiral phosphindane oxides exhibit promising therapeutic efficacy in autosomal dominant polycystic kidney disease (ADPKD), and compound 3az is found to significantly inhibit renal cyst growth both in vitro and in vivo, thus ushering in a promising scaffold for ADPKD drug discovery. This study will not only advance efforts towards the asymmetric synthesis of challenging P-stereogenic heterocycles, but also surely inspire further development of P-stereogenic entities for bioactive small-molecule discovery.

Published
2024
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189. Nationwide incidence of congenital and infantile cataract requiring surgery in Korea

Author

Dong Geun Kim, Da Yun Lee, Se Joon Woo, Kyu Hyung Park, and Sang Jun Park

Subjects
Medicine, Science
Abstract

Abstract Congenital and infantile (CI) cataract is one of the most important and preventable cause of blindness in children, but the incidence has not been studied in Korea. We collected data from the national claims database of the National Health Insurance Service of Korea from 2002 through 2019. We identified children who underwent cataract surgery within the age of 5 years, and cumulative incidence rates were calculated for each of the three age criteria. 989 patients out of 4,221,459 births underwent surgery with CI cataract during the period. The cumulative incidence rates per 10,000 births were 1.60 (0–1 years), 2.38 (0–3 years), and 2.95 (0–5 years), respectively. The incidence peaked in the 2007 birth cohort, which coincides with the start of the national screening program for infants/children. Primary intraocular lens implantation was performed in 439 patients (44%). Strabismus and glaucoma requiring surgery occurred in 291 patients (29.4%) and 32 patients (3.2%), respectively, within 8 years after cataract surgery. The incidence rates of CI cataract in Korea appear to be comparable to previous studies in other regions. The early screening program for infants may reduce delayed diagnosis and increase the proportion of patients undergoing surgery at a critical time for visual development.

Published
2024
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190. Deciphering the tumor immune microenvironment of imatinib-resistance in advanced gastrointestinal stromal tumors at single-cell resolution

Author

Xuechao Liu, Jing Yu, Yi Li, Hailei Shi, Xuelong Jiao, Xiaodong Liu, Dong Guo, Zequn Li, Yulong Tian, Fan Dai, Zhaojian Niu, and Yanbing Zhou

Subjects
Cytology, QH573-671
Abstract

Abstract The heterogeneous nature of tumors presents a considerable obstacle in addressing imatinib resistance in advanced cases of gastrointestinal stromal tumors (GIST). To address this issue, we conducted single-cell RNA-sequencing in primary tumors as well as peritoneal and liver metastases from patients diagnosed with locally advanced or advanced GIST. Single-cell transcriptomic signatures of tumor microenvironment (TME) were analyzed. Immunohistochemistry and multiplex immunofluorescence staining were used to further validate it. This analysis revealed unique tumor evolutionary patterns, transcriptome features, dynamic cell-state changes, and different metabolic reprogramming. The findings indicate that in imatinib-resistant TME, tumor cells with activated immune and cytokine-mediated immune responses interacted with a higher proportion of Treg cells via the TIGIT-NECTIN2 axis. Future immunotherapeutic strategies targeting Treg may provide new directions for the treatment of imatinib-resistant patients. In addition, IDO1+ dendritic cells (DC) were highly enriched in imatinib-resistant TME, interacting with various myeloid cells via the BTLA-TNFRSF14 axis, while the interaction was not significant in imatinib-sensitive TME. Our study highlights the transcriptional heterogeneity and distinct immunosuppressive microenvironment of advanced GIST, which provides novel therapeutic strategies and innovative immunotherapeutic agents for imatinib resistance.

Published
2024
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191. Malignancy risk stratification and subcategorization of K-TIRADS intermediate suspicion thyroid nodules: a retrospective multicenter study

Author

Boeun Lee, Dong Gyu Na, and Ji-hoon Kim

Subjects
thyroid nodule, thyroid neoplasms, ultrasonography, thyroid imaging reporting and data system, fine-needle aspiration, Medical technology, R855-855.5
Abstract

Purpose This study aimed to develop the ultrasonography (US) criteria for risk stratification of the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) 4 nodules, and to evaluate the diagnostic yield of a modified biopsy criterion in a multicenter cohort. Methods In total, 1,542 K-TIRADS 4 nodules (≥1 cm) were included in the study. US criteria for the subcategorization of K-TIRADS 4 nodules were developed based on high-risk US features. The diagnostic yields and false referral rates of biopsy criterion 1 (size cut-off of 1 cm), biopsy criterion 2 (size cut-off of 1.5 cm), and modified biopsy criterion 3 (size cut-off of 1 cm for K-TIRADS 4B and 1.5 cm for K-TIRADS 4A) were evaluated. Results The five high-risk US features (solid composition, marked hypoechogenicity, macrocalcification, punctate echogenic foci, and irregular margin) independently increased the malignancy risk of the K-TIRADS 4 nodules (P

Published
2024
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192. Impact of livestock industry on climate change: Case Study in South Korea — A review

Author

Sun Jin Hur, Jae Min Kim, Dong Gyun Yim, Yohan Yoon, Sang Suk Lee, and Cheorun Jo

Subjects
carbon footprint, climate change, environment, greenhouse gases, livestock industry, Zoology, QL1-991
Abstract

In recent years, there has been a growing argument attributing the primary cause of global climate change to livestock industry, which has led to the perception that the livestock industry is synonymous with greenhouse gas (GHG) emissions. However, a closer examination of the global GHG emission by sector reveals that the energy sector is responsible for the majority, accounting for 76.2% of the total, while agriculture contributes 11.9%. According to data from the Food and Agriculture Organization of the United Nations (FAO), the total GHG emissions associate with the livestock supply chain amount to 14.5%. Within this, emissions from direct sources, such as enteric fermentation and livestock manure treatment, which are not part of the front and rear industries, represent only 7%. Although it is true that the increase in meat consumption driven by global population growth and rising incomes, has contributed to higher methane (CH4) emissions resulting from enteric fermentation in ruminant animals, categorizing the livestock industry as the primary source of GHG emissions oversimplifies a complex issue and disregards objective data. Therefore, it may be a misleading to solely focus on the livestock sector without addressing the significant emissions from the energy sector, which is the largest contributor to GHG emissions. The top priority should be the objective and accurate measurement of GHG emissions, followed by the development and implementation of suitable reduction policies for each industrial sector with significant GHG emissions contributions.

Published
2024
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193. Effect of metastable retained austenite on dynamic mechanical properties of nanostructured bainitic steel under high-strain rate deformation

Author

Shichao Fan, Ziqing Xu, Hai Hao, Yu Bai, Xiaohu Deng, and Dong Guo

Subjects
Nanostructured bainite, Blocky retained austenite, High-strain rate deformation, Dynamic mechanical property, Austenitizing temperature, Mining engineering. Metallurgy, TN1-997
Abstract

In this study, modifying the austenitizing temperature offers a strategically viable way towards creating blocky retained austenite (BRA) with varying sizes and morphologies in nanostructured bainitic steel, in strikingly contrast to the conventional method of adjusting the austempering temperature. Dynamic tensile and compressive evaluation at different strain rates of 1 × 103 s−1 and 5 × 103 s−1 were carried out to gain insights into the effect of BRA stability on the dynamic mechanical properties and its intrinsic relationship with high strain rates. Additionally, the phase transformations and the triggered transformation-induced plasticity (TRIP) effects of BRA at different high strain rates were analyzed. The results reveal that during dynamic deformation, most of metastable BRA underwent a two-stage martensitic transformation of γ→εM and εM→α′M, while the filmy retained austenite exhibits minimal phase transformation. BRA dominates the TRIP effect under the extremely short deformation time and adiabatic heating conditioning. Consequently, samples containing more and larger-sized BRA demonstrated superior dynamic mechanical properties, including strength and fracture strain. As the strain rate increases, the TRIP effect induced by less stable BRA contributes to more pronounced enhancement of properties. Besides the deterioration effect originating from the early transformed brittle martensite also gradually intensifies with the strain rate, which is manifested by the appearance of quasi-cleavage facets at the fracture comparable to the BRA size. Nevertheless, during dynamic deformation, the metastable BRA induced TRIP effect significantly enhances the mechanical properties, outweighing its deteriorating effect. Moreover, less stable BRA should be favored at higher the strain rate.

Published
2024
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194. Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Author

Bailey M. H., Meyerson W. U., Dursi L. J., Wang L. -B., Dong G., Liang W. -W., Weerasinghe A., Li S., Li Y., Kelso S., Akbani R., Anur P., Buchanan A., Chiotti K., Covington K., Creason A., Ding L., Ellrott K., Fan Y., Foltz S., Getz G., Hale W., Haussler D., Hess J. M., Hutter C. M., Kandoth C., Kasaian K., Kasapi M., Larson D., Leshchiner I., Letaw J., Ma S., McLellan M. D., Men Y., Mills G. B., Niu B., Peto M., Radenbaugh A., Reynolds S. M., Saksena G., Sofia H., Stewart C., Struck A. J., Stuart J. M., Wang W., Weinstein J. N., Wheeler D. A., Wong C. K., Xi L., Ye K., Bieg M., Boutros P. C., Buchhalter I., Butler A. P., Chen K., Chong Z., Drechsel O., Jonathan Dursi L., Eils R., Espiritu S. M. G., Fulton R. S., Gao S., Gelpi J. L., Gerstein M. B., Gonzalez S., Gut I. G., Hach F., Heinold M. C., Hinton J., Hu T., Huang V., Huang Y., Hutter B., Jones D. R., Jung J., Jager N., Kim H. -L., Kleinheinz K., Kumar S., Kumar Y., Lalansingh C. M., Letunic I., Livitz D., Ma E. Z., Maruvka Y. E., Mashl R. J., Menzies A., Milovanovic A., Nielsen M. M., Ossowski S., Paramasivam N., Pedersen J. S., Perry M. D., Puiggros M., Raine K. M., Rheinbay E., Royo R., Sahinalp S. C., Sarrafi I., Schlesner M., Simpson J. T., Stebbings L., Stobbe M. D., Teague J. W., Tiao G., Torrents D., Wala J. A., Wang J., Waszak S. M., Weischenfeldt J., Wendl M. C., Werner J., Wu Z., Xue H., Yakneen S., Yamaguchi T. N., Yellapantula V. D., Yung C. K., Zhang J., Aaltonen L. A., Abascal F., Abeshouse A., Aburatani H., Adams D. J., Agrawal N., Ahn K. S., Ahn S. -M., Aikata H., Akdemir K. C., Al-Ahmadie H., Al-Sedairy S. T., Al-Shahrour F., Alawi M., Albert M., Aldape K., Alexandrov L. B., Ally A., Alsop K., Alvarez E. G., Amary F., Amin S. B., Aminou B., Ammerpohl O., Anderson M. J., Ang Y., Antonello D., Aparicio S., Appelbaum E. L., Arai Y., Aretz A., Arihiro K., Ariizumi S. -I., Armenia J., Arnould L., Asa S., Assenov Y., Atwal G., Aukema S., Auman J. T., Aure M. R., Awadalla P., Aymerich M., Bader G. D., Baez-Ortega A., Bailey P. J., Balasundaram M., Balu S., Bandopadhayay P., Banks R. E., Barbi S., Barbour A. P., Barenboim J., Barnholtz-Sloan J., Barr H., Barrera E., Bartlett J., Bartolome J., Bassi C., Bathe O. F., Baumhoer D., Bavi P., Baylin S. B., Bazant W., Beardsmore D., Beck T. A., Behjati S., Behren A., Bell C., Beltran S., Benz C., Berchuck A., Bergmann A. K., Bergstrom E. N., Berman B. P., Berney D. M., Bernhart S. H., Beroukhim R., Berrios M., Bersani S., Bertl J., Betancourt M., Bhandari V., Bhosle S. G., Biankin A. V., Bigner D., Binder H., Birney E., Birrer M., Biswas N. K., Bjerkehagen B., Bodenheimer T., Boice L., Bonizzato G., De Bono J. S., Boot A., Bootwalla M. S., Borg A., Borkhardt A., Boroevich K. A., Borozan I., Borst C., Bosenberg M., Bosio M., Boultwood J., Bourque G., Bova G. S., Bowen D. T., Bowlby R., Bowtell D. D. L., Boyault S., Boyce R., Boyd J., Brazma A., Brennan P., Brewer D. S., Brinkman A. B., Bristow R. G., Broaddus R. R., Brock J. E., Brock M., Broeks A., Brooks A. N., Brooks D., Brors B., Brunak S., Bruxner T. J. C., Bruzos A. L., Buchholz C., Bullman S., Burke H., Burkhardt B., Burns K. H., Busanovich J., Bustamante C. D., Butte A. J., Byrne N. J., Borresen-Dale A. -L., Caesar-Johnson S. J., Cafferkey A., Cahill D., Calabrese C., Caldas C., Calvo F., Camacho N., Campbell P. J., Campo E., Cantu C., Cao S., Carey T. E., Carlevaro-Fita J., Carlsen R., Cataldo I., Cazzola M., Cebon J., Cerfolio R., Chadwick D. E., Chakravarty D., Chalmers D., Chan C. W. Y., Chan K., Chan-Seng-Yue M., Chandan V. S., Chang D. K., Chanock S. J., Chantrill L. A., Chateigner A., Chatterjee N., Chayama K., Chen H. -W., Chen J., Chen Y., Chen Z., Cherniack A. D., Chien J., Chiew Y. -E., Chin S. -F., Cho J., Cho S., Choi J. K., Choi W., Chomienne C., Choo S. P., Chou A., Christ A. N., Christie E. L., Chuah E., Cibulskis C., Cibulskis K., Cingarlini S., Clapham P., Claviez A., Cleary S., Cloonan N., Cmero M., Collins C. C., Connor A. A., Cooke S. L., Cooper C. S., Cope L., Corbo V., Cordes M. G., Cordner S. M., Cortes-Ciriano I., Cowin P. A., Craft B., Craft D., Creighton C. J., Cun Y., Curley E., Cutcutache I., Czajka K., Czerniak B., Dagg R. A., Danilova L., Davi M. V., Davidson N. R., Davies H., Davis I. J., Davis-Dusenbery B. N., Dawson K. J., De La Vega F. M., De Paoli-Iseppi R., Defreitas T., Dei Tos A. P., Delaneau O., Demchok J. A., Demeulemeester J., Demidov G. M., Demircioglu D., Dennis N. M., Denroche R. E., Dentro S. C., Desai N., Deshpande V., Deshwar A. G., Desmedt C., Deu-Pons J., Dhalla N., Dhani N. C., Dhingra P., Dhir R., DiBiase A., Diamanti K., Ding S., Dinh H. Q., Dirix L., Doddapaneni H. V., Donmez N., Dow M. T., Drapkin R., Drews R. M., Serge S., Dudderidge T., Dueso-Barroso A., Dunford A. J., Dunn M., Duthie F. R., Dutton-Regester K., Eagles J., Easton D. F., Edmonds S., Edwards P. A., Edwards S. E., Eeles R. A., Ehinger A., Eils J., El-Naggar A., Eldridge M., Erkek S., Escaramis G., Estivill X., Etemadmoghadam D., Eyfjord J. E., Faltas B. M., Fan D., Faquin W. C., Farcas C., Fassan M., Fatima A., Favero F., Fayzullaev N., Felau I., Fereday S., Ferguson M. L., Ferretti V., Feuerbach L., Field M. A., Fink J. L., Finocchiaro G., Fisher C., Fittall M. W., Fitzgerald A., Fitzgerald R. C., Flanagan A. M., Fleshner N. E., Flicek P., Foekens J. A., Fong K. M., Fonseca N. A., Foster C. S., Fox N. S., Fraser M., Frazer S., Frenkel-Morgenstern M., Friedman W., Frigola J., Fronick C. C., Fujimoto A., Fujita M., Fukayama M., Fulton L. A., Furuta M., Futreal P. A., Fullgrabe A., Gabriel S. B., Gallinger S., Gambacorti Passerini C., Gao J., Garraway L., Garred O., Garrison E., Garsed D. W., Gehlenborg N., George J., Gerhard D. S., Gerhauser C., Gershenwald J. E., Gerstung M., Ghori M., Ghossein R., Giama N. H., Gibbs R. A., Gill A. J., Gill P., Giri D. D., Glodzik D., Gnanapragasam V. J., Goebler M. E., Goldman M. J., Gomez C., Gonzalez-Perez A., Gordenin D. A., Gossage J., Gotoh K., Govindan R., Grabau D., Graham J. S., Grant R. C., Green A. R., Green E., Greger L., Grehan N., Grimaldi S., Grimmond S. M., Grossman R. L., Grundhoff A., Gundem G., Guo Q., Gupta M., Gupta S., Gut M., Goke J., Ha G., Haake A., Haan D., Haas S., Haase K., Haber J. E., Habermann N., Haider S., Hama N., Hamdy F. C., Hamilton A., Hamilton M. P., Han L., Hanna G. B., Hansmann M., Haradhvala N. J., Harismendy O., Harliwong I., Harmanci A. O., Harrington E., Hasegawa T., Hawkins S., Hayami S., Hayashi S., Hayes D. N., Hayes S. J., Hayward N. K., Hazell S., He Y., Heath A. P., Heath S. C., Hedley D., Hegde A. M., Heiman D. I., Heins Z., Heisler L. E., Hellstrom-Lindberg E., Helmy M., Heo S. G., Hepperla A. J., Heredia-Genestar J. M., Herrmann C., Hersey P., Hilmarsdottir H., Hirano S., Hiraoka N., Hoadley K. A., Hobolth A., Hodzic E., Hoell J. I., Hoffmann S., Hofmann O., Holbrook A., Holik A. Z., Hollingsworth M. A., Holmes O., Holt R. A., Hong C., Hong E. P., Hong J. H., Hooijer G. K., Hornshoj H., Hosoda F., Hou Y., Hovestadt V., Howat W., Hoyle A. P., Hruban R. H., Hu J., Hua X., Huang K. -L., Huang M., Huang M. N., Huber W., Hudson T. J., Hummel M., Hung J. A., Huntsman D., Hupp T. R., Huse J., Huska M. R., Hubschmann D., Iacobuzio-Donahue C. A., Imbusch C. D., Imielinski M., Imoto S., Isaacs W. B., Isaev K., Ishikawa S., Iskar M., Islam S. M. A., Ittmann M., Ivkovic S., Izarzugaza J. M. G., Jacquemier J., Jakrot V., Jamieson N. B., Jang G. H., Jang S. J., Jayaseelan J. C., Jayasinghe R., Jefferys S. R., Jegalian K., Jennings J. L., Jeon S. -H., Jerman L., Ji Y., Jiao W., Johansson P. A., Johns A. L., Johns J., Johnson R., Johnson T. A., Jolly C., Joly Y., Jonasson J. G., Jones C. D., Jones D. T. W., Jones N., Jones S. J. M., Jonkers J., Ju Y. S., Juhl H., Juul M., Juul R. I., Juul S., Kabbe R., Kahles A., Kahraman A., Kaiser V. B., Kakavand H., Kalimuthu S., von Kalle C., Kang K. J., Karaszi K., Karlan B., Karlic R., Karsch D., Kassahn K. S., Katai H., Kato M., Katoh H., Kawakami Y., Kay J. D., Kazakoff S. H., Kazanov M. D., Keays M., Kebebew E., Kefford R. F., Kellis M., Kench J. G., Kennedy C. J., Kerssemakers J. N. A., Khoo D., Khoo V., Khuntikeo N., Khurana E., Kilpinen H., Kim H. K., Kim H. -Y., Kim H., Kim J., Kim J. K., Kim Y., King T. A., Klapper W., Klimczak L. J., Knappskog S., Kneba M., Knoppers B. M., Koh Y., Jan Komorowski, Komura D., Komura M., Kong G., Kool M., Korbel J. O., Korchina V., Korshunov A., Koscher M., Koster R., Kote-Jarai Z., Koures A., Kovacevic M., Kremeyer B., Kretzmer H., Kreuz M., Krishnamurthy S., Kube D., Kumar K., Kumar P., Kundra R., Kubler K., Kuppers R., Lagergren J., Lai P. H., Laird P. W., Lakhani S. R., Lalonde E., Lamaze F. C., Lambert A., Lander E., Landgraf P., Landoni L., Langerod A., Lanzos A., Larsimont D., Larsson E., Lathrop M., Lau L. M. S., Lawerenz C., Lawlor R. T., Lawrence M. S., Lazar A. J., Le X., Lee D., Lee E. A., Lee H. J., Lee J. J. -K., Lee J. -Y., Lee J., Lee M. T. M., Lee-Six H., Lehmann K. -V., Lehrach H., Lenze D., Leonard C. R., Leongamornlert D. A., Letourneau L., Levine D. A., Lewis L., Ley T., Li C., Li C. H., Li H. I., Li J., Li L., Li X., Liang H., Liang S. -B., Lichter P., Lin P., Lin Z., Linehan W. M., Lingjaerde O. C., Liu D., Liu E. M., Liu F. -F., Liu F., Liu J., Liu X., Livingstone J., Livni N., Lochovsky L., Loeffler M., Long G. V., Lopez-Guillermo A., Lou S., Louis D. N., Lovat L. B., Lu Y., Lu Y. -J., Luchini C., Lungu I., Luo X., Luxton H. J., Lynch A. G., Lype L., Lopez C., Lopez-Otin C., Ma Y., MacGrogan G., MacRae S., Macintyre G., Madsen T., Maejima K., Mafficini A., Maglinte D. T., Maitra A., Majumder P. P., Malcovati L., Malikic S., Malleo G., Mann G. J., Mantovani-Loffler L., Marchal K., Marchegiani G., Mardis E. R., Margolin A. A., Marin M. G., Markowetz F., Markowski J., Marks J., Marques-Bonet T., Marra M. A., Marsden L., Martens J. W. M., Martin S., Martin-Subero J. I., Martincorena I., Martinez-Fundichely A., Massie C. E., Matthew T. J., Matthews L., Mayer E., Mayes S., Mayo M., Mbabaali F., McCune K., McDermott U., McGillivray P. D., McPherson J. D., McPherson J. R., McPherson T. A., Meier S. R., Meng A., Meng S., Merrett N. D., Merson S., Meyerson M., Mieczkowski P. A., Mihaiescu G. L., Mijalkovic S., Mijalkovic-Lazic A. M., Mikkelsen T., Milella M., Mileshkin L., Miller C. A., Miller D. K., Miller J. K., Minner S., Miotto M., Arnau G. M., Mirabello L., Mitchell C., Mitchell T. J., Miyano S., Miyoshi N., Mizuno S., Molnar-Gabor F., Moore M. J., Moore R. A., Morganella S., Morris Q. D., Morrison C., Mose L. E., Moser C. D., Muinos F., Mularoni L., Mungall A. J., Mungall K., Musgrove E. A., Mustonen V., Mutch D., Muyas F., Muzny D. M., Munoz A., Myers J., Myklebost O., Moller P., Nagae G., Nagrial A. M., Nahal-Bose H. K., Nakagama H., Nakagawa H., Nakamura H., Nakamura T., Nakano K., Nandi T., Nangalia J., Nastic M., Navarro A., Navarro F. C. P., Neal D. E., Nettekoven G., Newell F., Newhouse S. J., Newton Y., Ng A. W. T., Ng A., Nicholson J., Nicol D., Nie Y., Nielsen G. P., Nik-Zainal S., Noble M. S., Nones K., Northcott P. A., Notta F., O'Connor B. D., O'Donnell P., O'Donovan M., O'Meara S., O'Neill B. P., O'Neill J. R., Ocana D., Ochoa A., Oesper L., Ogden C., Ohdan H., Ohi K., Ohno-Machado L., Oien K. A., Ojesina A. I., Ojima H., Okusaka T., Omberg L., Ong C. K., Ott G., Ouellette B. F. F., P'ng C., Paczkowska M., Paiella S., Pairojkul C., Pajic M., Pan-Hammarstrom Q., Papaemmanuil E., Papatheodorou I., Park J. W., Park J. -W., Park K., Park P. J., Parker J. S., Parsons S. L., Pass H., Pasternack D., Pastore A., Patch A. -M., Pauporte I., Pea A., Pearson J. V., Pedamallu C. S., Pederzoli P., Peifer M., Pennell N. A., Perou C. M., Petersen G. M., Petrelli N., Petryszak R., Pfister S. M., Phillips M., Pich O., Pickett H. A., Pihl T. D., Pillay N., Pinder S., Pinese M., Pinho A. V., Pitkanen E., Pivot X., Pineiro-Yanez E., Planko L., Plass C., Polak P., Pons T., Popescu I., Potapova O., Prasad A., Preston S. R., Prinz M., Pritchard A. L., Prokopec S. D., Provenzano E., Puente X. S., Puig S., Pulido-Tamayo S., Pupo G. M., Purdie C. A., Quinn M. C., Rabionet R., Rader J. S., Radlwimmer B., Radovic P., Raeder B., Ramakrishna M., Ramakrishnan K., Ramalingam S., Raphael B. J., Rathmell W. K., Rausch T., Reifenberger G., Reimand J., Reis-Filho J., Reuter V., Reyes-Salazar I., Reyna M. A., Riazalhosseini Y., Richardson A. L., Richter J., Ringel M., Ringner M., Rino Y., Rippe K., Roach J., Roberts L. R., Roberts N. D., Roberts S. A., Robertson A. G., Robertson A. J., Rodriguez J. B., Rodriguez-Martin B., Rodriguez-Gonzalez F. G., Roehrl M. H. A., Rohde M., Rokutan H., Romieu G., Rooman I., Roques T., Rosebrock D., Rosenberg M., Rosenstiel P. C., Rosenwald A., Rowe E. W., Rozen S. G., Rubanova Y., Rubin M. A., Rubio-Perez C., Rudneva V. A., Rusev B. C., Ruzzenente A., Ratsch G., Sabarinathan R., Sabelnykova V. Y., Sadeghi S., Saini N., Saito-Adachi M., Salcedo A., Salgado R., Salichos L., Sallari R., Saller C., Salvia R., Sam M., Samra J. S., Sanchez-Vega F., Sander C., Sanders G., Sarin R., Sasaki-Oku A., Sauer T., Sauter G., Saw R. P. M., Scardoni M., Scarlett C. J., Scarpa A., Scelo G., Schadendorf D., Schein J. E., Schilhabel M. B., Schlomm T., Schmidt H. K., Schramm S. -J., Schreiber S., Schultz N., Schumacher S. E., Schwarz R. F., Scolyer R. A., Scott D., Scully R., Seethala R., Segre A. V., Selander I., Semple C. A., Senbabaoglu Y., Sengupta S., Sereni E., Serra S., Sgroi D. C., Shackleton M., Shah N. C., Shahabi S., Shang C. A., Shang P., Shapira O., Shelton T., Shen C., Shen H., Shepherd R., Shi R., Shi Y., Shiah Y. -J., Shibata T., Shih J., Shimizu E., Shimizu K., Shin S. J., Shiraishi Y., Shmaya T., Shmulevich I., Shorser S. I., Short C., Shrestha R., Shringarpure S. S., Shriver C., Shuai S., Sidiropoulos N., Siebert R., Sieuwerts A. M., Sieverling L., Signoretti S., Sikora K. O., Simbolo M., Simon R., Simons J. V., Singer S., Sinnott-Armstrong N., Sipahimalani P., Skelly T. J., Smid M., Smith J., Smith-McCune K., Socci N. D., Sofia H. J., Soloway M. G., Song L., Sood A. K., Sothi S., Sotiriou C., Soulette C. M., Span P. N., Spellman P. T., Sperandio N., Spillane A. J., Spiro O., Spring J., Staaf J., Stadler P. F., Staib P., Stark S. G., Stefansson O. A., Stegle O., Stein L. D., Stenhouse A., Stilgenbauer S., Stratton M. R., Stretch J. R., Stunnenberg H. G., Su H., Su X., Sun R. X., Sungalee S., Susak H., Suzuki A., Sweep F., Szczepanowski M., Sultmann H., Yugawa T., Tam A., Tamborero D., Tan B. K. T., Tan D., Tan P., Tanaka H., Taniguchi H., Tanskanen T. J., Tarabichi M., Tarnuzzer R., Tarpey P., Taschuk M. L., Tatsuno K., Tavare S., Taylor D. F., Taylor-Weiner A., Teh B. T., Tembe V., Temes J., Thai K., Thayer S. P., Thiessen N., Thomas G., Thomas S., Thompson A., Thompson A. M., Thompson J. F., Thompson R. H., Thorne H., Thorne L. B., Thorogood A., Tijanic N., Timms L. E., Tirabosco R., Tojo M., Tommasi S., Toon C. W., Toprak U. H., Tortora G., Tost J., Totoki Y., Townend D., Traficante N., Treilleux I., Trotta J. -R., Trumper L. H. P., Tsao M., Tsunoda T., Tubio J. M. C., Tucker O., Turkington R., Turner D. J., Tutt A., Ueno M., Ueno N. T., Umbricht C., Umer H. M., Underwood T. J., Urban L., Urushidate T., Ushiku T., Uuskula-Reimand L., Valencia A., Van Den Berg D. J., Van Laere S., Van Loo P., Van Meir E. G., Van den Eynden G. G., Van der Kwast T., Vasudev N., Vazquez M., Vedururu R., Veluvolu U., Vembu S., Verbeke L. P. 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Y., Yang L., Yang S., Yang T. -P., Yang Y., Yao X., Yaspo M. -L., Yates L., Yau C., Ye C., Yoon C. J., Yoon S. -S., Yousif F., Yu J., Yu K., Yu W., Yu Y., Yuan K., Yuan Y., Yuen D., Zaikova O., Zamora J., Zapatka M., Zenklusen J. C., Zenz T., Zeps N., Zhang C. -Z., Zhang F., Zhang H., Zhang X., Zhang Y., Zhang Z., Zhao Z., Zheng L., Zheng X., Zhou W., Zhou Y., Bin Zhu, Zhu H., Zhu J., Zhu S., Zou L., Zou X., deFazio A., van As N., van Deurzen C. H. M., van de Vijver M. 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Veluvolu, U, Vembu, S, Verbeke, L, Vermeulen, P, Verrill, C, Viari, A, Vicente, D, Vicentini, C, Raghavan, K, Viksna, J, Vilain, R, Villasante, I, Vincent-Salomon, A, Visakorpi, T, Voet, D, Vyas, P, Vazquez-Garcia, I, Waddell, N, Wadelius, C, Wadi, L, Wagener, R, Wang, Q, Wang, Y, Wang, Z, Waring, P, Warnatz, H, Warrell, J, Warren, A, Wedge, D, Weichenhan, D, Weinberger, P, Weisenberger, D, Welch, I, Whalley, J, Whitaker, H, Wigle, D, Wilkerson, M, Williams, A, Wilmott, J, Wilson, G, Wilson, J, Wilson, R, Winterhoff, B, Wintersinger, J, Wiznerowicz, M, Wolf, S, Wong, B, Wong, T, Wong, W, Woo, Y, Wood, S, Wouters, B, Wright, A, Wright, D, Wright, M, Wu, C, Wu, D, Wu, G, Wu, J, Wu, K, Wu, Y, Xia, T, Xiang, Q, Xiao, X, Xing, R, Xiong, H, Xu, Q, Xu, Y, Yachida, S, Yamaguchi, R, Yamamoto, M, Yamamoto, S, Yamaue, H, Yang, F, Yang, H, Yang, J, Yang, L, Yang, S, Yang, T, Yang, Y, Yao, X, Yaspo, M, Yates, L, Yau, C, Ye, C, Yoon, C, Yoon, S, Yousif, F, Yu, J, Yu, K, Yu, W, Yu, Y, Yuan, K, Yuan, Y, Yuen, D, Zaikova, O, Zamora, J, Zapatka, M, Zenklusen, J, Zenz, T, Zeps, N, Zhang, C, Zhang, F, Zhang, H, Zhang, X, Zhang, Y, Zhang, Z, Zhao, Z, Zheng, L, Zheng, X, Zhou, W, Zhou, Y, Bin, Z, Zhu, H, Zhu, J, Zhu, S, Zou, L, Zou, X, Defazio, A, van As, N, van Deurzen, C, van de Vijver, M, van't Veer, L, von Mering, C, University of Zurich, Gerstein, Mark B, Ding, Li, and Faculty of Economic and Social Sciences and Solvay Business School

Subjects
Science, MEDLINE, Medizin, General Physics and Astronomy, Pain, 610 Medicine & health, 1600 General Chemistry, Computational biology, Biology, 10 kHz spinal cord stimulation, Genome, responders, MC3 Working Group, General Biochemistry, Genetics and Molecular Biology, whole exome sequencing, Machine Learning, 1300 General Biochemistry, Genetics and Molecular Biology, PCAWG novel somatic mutation calling methods working group, medicine, cancer, Genome mutation, Exome, Exome sequencing, Whole genome sequencing, whole genome sequencing, Multidisciplinary, Published Erratum, Cancer, PCAWG Consortium, General Chemistry, medicine.disease, 3100 General Physics and Astronomy, oncology, 10032 Clinic for Oncology and Hematology, Prediction
Abstract

Weitere Nicht-UDE-Autoren sind nicht genannt. Originalpublikation: 10.1038/s41467-020-18151-y. CA extern The original version of this Article omitted from the author list the 9th author Yize Li, who is from the ‘The McDonnell Genome Institute at Washington University, St. Louis, MO 63108, USA and Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA’. This has been corrected in both the PDF and HTML versions of the Article. © 2020, The Author(s).

Published
2020

196. On the monotonicity of (LDL) logic programs with set

Author

Dong, G., Goos, G., editor, Hartmanis, J., editor, Barstow, D., editor, Brauer, W., editor, Brinch Hansen, P., editor, Gries, D., editor, Luckham, D., editor, Moler, C., editor, Pnueli, A., editor, Seegmüller, G., editor, Stoer, J., editor, Wirth, N., editor, Thalheim, Bernhard, editor, Demetrovics, János, editor, and Gerhardt, H. -D., editor

Published
1991
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197. Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar

Author

Isch, C., Majneri, P., Landrein, N., Pivovarova, Y., Lesigang, J., Lauruol, F., Robinson, D.R., Dong, G., Bonhivers, M., Microbiologie cellulaire et moléculaire et pathogénicité (MCMP), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), and Medizinische Universität Wien = Medical University of Vienna

Subjects
Organelles, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Protein Conformation, QH301-705.5, Trypanosoma brucei brucei, Protozoan Proteins, Sequence Homology, RC581-607, Crystallography, X-Ray, Flagella, Two-Hybrid System Techniques, Protein Interaction Domains and Motifs, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Amino Acid Sequence, Immunologic diseases. Allergy, Biology (General), Cytoskeleton, Cytokinesis, Research Article
Abstract

The flagellar pocket (FP) is the only endo- and exocytic organelle in most trypanosomes and, as such, is essential throughout the life cycle of the parasite. The neck of the FP is maintained enclosed around the flagellum via the flagellar pocket collar (FPC). The FPC is a macromolecular cytoskeletal structure and is essential for the formation of the FP and cytokinesis. FPC biogenesis and structure are poorly understood, mainly due to the lack of information on FPC composition. To date, only two FPC proteins, BILBO1 and FPC4, have been characterized. BILBO1 forms a molecular skeleton upon which other FPC proteins can, theoretically, dock onto. We previously identified FPC4 as the first BILBO1 interacting partner and demonstrated that its C-terminal domain interacts with the BILBO1 N-terminal domain (NTD). Here, we report by yeast two-hybrid, bioinformatics, functional and structural studies the characterization of a new FPC component and BILBO1 partner protein, BILBO2 (Tb927.6.3240). Further, we demonstrate that BILBO1 and BILBO2 share a homologous NTD and that both domains interact with FPC4. We have determined a 1.9 Å resolution crystal structure of the BILBO2 NTD in complex with the FPC4 BILBO1-binding domain. Together with mutational analyses, our studies reveal key residues for the function of the BILBO2 NTD and its interaction with FPC4 and evidenced a tripartite interaction between BILBO1, BILBO2, and FPC4. Our work sheds light on the first atomic structure of an FPC protein complex and represents a significant step in deciphering the FPC function in Trypanosoma brucei and other pathogenic kinetoplastids., Author summary Trypanosomes belong to a group of zoonotic, protist, parasites that are found in Africa, Asia, South America, and Europe and are responsible for severe human and animal diseases. They all have a common structure called the flagellar pocket (FP). In most trypanosomes, all macromolecular exchanges between the trypanosome and the environment occur via the FP. The FP is thus essential for cell viability and evading the host immune response. We have been studying the flagellar pocket collar (FPC), an enigmatic macromolecular structure at the neck of the FP, and demonstrated its essentiality for the biogenesis of the FP. We demonstrated that BILBO1 is an essential protein of the FPC that interacts with other proteins including a microtubule-binding protein FPC4. Here we identify another bona fide FPC protein, BILBO2, so named because of close similarity with BILBO1 in protein localization and functional domains. We demonstrate that BILBO1 and BILBO2 share a common N-terminal domain involved in the interaction with FPC4, and illustrate a tripartite interaction between BILBO1, BILBO2, and FPC4. Our study also provides the first atomic view of two FPC components. These data represent an additional step in deciphering the FPC structure and function in T. brucei.

Published
2021

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