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151. Community engagement among forest goers in a malaria prophylaxis trial: implementation challenges and implications

Author

Conradis-Jansen, Franca, primary, Tripura, Rupam, additional, Peto, Thomas J., additional, Callery, James J., additional, Adhikari, Bipin, additional, Ean, Mom, additional, Jongdeepaisal, Monnaphat, additional, Pell, Christopher, additional, Khonputsa, Panarasri, additional, Murgia, Riccardo, additional, Sovannaroth, Siv, additional, Müller, Olaf, additional, Cheah, Phaik Yeong, additional, Dondorp, Arjen M., additional, von Seidlein, Lorenz, additional, and Maude, Richard J., additional

Published
2023
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152. Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open- label, randomised, controlled adaptive platform trial

Author

Luvira, Viravarn, primary, Schilling, William HK, additional, Jittamala, Podjanee, additional, Watson, James A, additional, Boyd, Simon, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Almeida, Pedro J, additional, Ekkapongpisit, Maneerat, additional, Cruz, Cintia, additional, Callery, James J, additional, Singh, Shivani, additional, Tuntipaiboontana, Runch, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Keayarsa, Srisuda, additional, Madmanee, Wanassanan, additional, Aguiar, Renato S, additional, Santos, Franciele M, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Poovorawan, Kittiyod, additional, Imwong, Mallika, additional, Taylor, Walter RJ, additional, Chotivanich, Vasin, additional, Chotivanich, Kesinee, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2023
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153. Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial

Author

Taylor, Walter R, primary, Olupot-Olupot, Peter, additional, Onyamboko, Marie A, additional, Peerawaranun, Pimnara, additional, Weere, Winifred, additional, Namayanja, Cate, additional, Onyas, Peter, additional, Titin, Harriet, additional, Baseke, Joy, additional, Muhindo, Rita, additional, Kayembe, Daddy K, additional, Ndjowo, Pauline O, additional, Basara, Benjamin B, additional, Bongo, Georgette S, additional, Okalebo, Charles B, additional, Abongo, Grace, additional, Uyoga, Sophie, additional, Williams, Thomas N, additional, Taya, Chiraporn, additional, Dhorda, Mehul, additional, Tarning, Joel, additional, Dondorp, Arjen M, additional, Waithira, Naomi, additional, Fanello, Caterina, additional, Maitland, Kathryn, additional, Mukaka, Mavuto, additional, and Day, Nicholas J P, additional

Published
2023
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154. Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation : a WorldWide Antimalarial Resistance Network individual patient data meta-analysis

Author

Wynberg, Elke, Commons, Robert J., Humphreys, Georgina, Ashurst, Hazel, Burrow, Rebekah, Adjei, George O., Adjuik, Martin, Anstey, Nicholas M., Anvikar, Anup, Baird, Kevin J., Barber, Bridget E., Barennes, Hubert, Baudin, Elisabeth, Bell, David J., Bethell, Delia, Binh, Tran Quang, Borghini, Isabelle, Chu, Cindy S., Daher, Andre, D'Alessandro, Umberto, Das, Debashish, Davis, Timothy Me, de Vries, Peter J., Djimde, Abdoulaye A., Dondorp, Arjen M., Dorsey, Grant, Faucher, Jean-Francois F., Fogg, Carole, Gaye, Oumar, Grigg, Matthew, Hatz, Christoph, Kager, Piet A., Lacerda, Marcus, Laman, Moses, Mårtensson, Andreas, Menan, Herve Ignace Eby, Monteiro, Wuelton M., Moore, Brioni R., Nosten, Francois, Ogutu, Bernhards, Osorio, Lyda, Penali, Louis K., Pereira, Dhelio B., Rahim, Awab G., Ramharter, Michael, Sagara, Issaka, Schramm, Birgit, Seidlein, Lorenz, Siqueira, Andre M., Sirima, Sodiomon B., Starzengruber, Peter, Sutanto, Inge, Taylor, Walter R., Toure, Offianan A., Utzinger, Jurg, Valea, Innocent, Valentini, Giovanni, White, Nicholas J., William, Timothy, Woodrow, Charles J., Richmond, Caitlin L., Guerin, Philippe J., Price, Ric N., Stepniewska, Kasia, Wynberg, Elke, Commons, Robert J., Humphreys, Georgina, Ashurst, Hazel, Burrow, Rebekah, Adjei, George O., Adjuik, Martin, Anstey, Nicholas M., Anvikar, Anup, Baird, Kevin J., Barber, Bridget E., Barennes, Hubert, Baudin, Elisabeth, Bell, David J., Bethell, Delia, Binh, Tran Quang, Borghini, Isabelle, Chu, Cindy S., Daher, Andre, D'Alessandro, Umberto, Das, Debashish, Davis, Timothy Me, de Vries, Peter J., Djimde, Abdoulaye A., Dondorp, Arjen M., Dorsey, Grant, Faucher, Jean-Francois F., Fogg, Carole, Gaye, Oumar, Grigg, Matthew, Hatz, Christoph, Kager, Piet A., Lacerda, Marcus, Laman, Moses, Mårtensson, Andreas, Menan, Herve Ignace Eby, Monteiro, Wuelton M., Moore, Brioni R., Nosten, Francois, Ogutu, Bernhards, Osorio, Lyda, Penali, Louis K., Pereira, Dhelio B., Rahim, Awab G., Ramharter, Michael, Sagara, Issaka, Schramm, Birgit, Seidlein, Lorenz, Siqueira, Andre M., Sirima, Sodiomon B., Starzengruber, Peter, Sutanto, Inge, Taylor, Walter R., Toure, Offianan A., Utzinger, Jurg, Valea, Innocent, Valentini, Giovanni, White, Nicholas J., William, Timothy, Woodrow, Charles J., Richmond, Caitlin L., Guerin, Philippe J., Price, Ric N., and Stepniewska, Kasia

Abstract

Background: The World Health Organization (WHO) recommends that when peripheral malarial parasitaemia is quantified by thick film microscopy, an actual white blood cell (WBC) count from a concurrently collected blood sample is used in calculations. However, in resource-limited settings an assumed WBC count is often used instead. The aim of this study was to describe the variability in WBC count during acute uncomplicated malaria, and estimate the impact of using an assumed value of WBC on estimates of parasite density and clearance. Methods: Uncomplicated malaria drug efficacy studies that measured WBC count were selected from the WorldWide Antimalarial Resistance Network data repository for an individual patient data meta-analysis of WBC counts. Regression models with random intercepts for study-site were used to assess WBC count variability at presentation and during follow-up. Inflation factors for parasitaemia density, and clearance estimates were calculated for methods using assumed WBC counts (8000 cells/mu L and age-stratified values) using estimates derived from the measured WBC value as reference. Results: Eighty-four studies enrolling 27,656 patients with clinically uncomplicated malaria were included. Geometric mean WBC counts (x 1000 cells/mu L) in age groups < 1, 1-4, 5-14 and >= 15 years were 10.5, 8.3, 7.1, 5.7 and 7.5, 7.0, 6.5, 6.0 for individuals with falciparum (n = 24,978) and vivax (n = 2678) malaria, respectively. At presentation, higher WBC counts were seen among patients with higher parasitaemia, severe anaemia and, for individuals with vivax malaria, in regions with shorter regional relapse periodicity. Among falciparum malaria patients, using an assumed WBC count of 8000 cells/mu L resulted in parasite density underestimation by a median (IQR) of 26% (4-41%) in infants < 1 year old but an overestimation by 50% (16-91%) in adults aged = 15 years. Use of age-stratified assumed WBC values removed systematic bias but did not improve pr

Published
2023
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155. Exploring the feasibility of introducing triple artemisinin-based combination therapy in the malaria treatment policy in Vietnam

Author

Innovation and Sustainability, Dep of Sustainable Development, Innovation Studies, Cao, Van Anh Thi, Nguyen, Thieu Quang, Le Quyen, Duong, Boon, Wouter P C, Moors, Ellen H M, Dondorp, Arjen M, de Haan, Freek, Amaratunga, Chanaki, Innovation and Sustainability, Dep of Sustainable Development, Innovation Studies, Cao, Van Anh Thi, Nguyen, Thieu Quang, Le Quyen, Duong, Boon, Wouter P C, Moors, Ellen H M, Dondorp, Arjen M, de Haan, Freek, and Amaratunga, Chanaki

Published
2023

156. The impact of anti-malarial markets on artemisinin resistance: perspectives from Burkina Faso

Author

Innovation and Sustainability, Dep of Sustainable Development, Innovation Studies, Guissou, Rosemonde M., Amaratunga, Chanaki, de Haan, Freek, Tou, Fatoumata, Cheah, Phaik Yeong, Yerbanga, R. Serge, Moors, Ellen H.M., Dhorda, Mehul, Tindana, Paulina, Boon, Wouter P.C., Dondorp, Arjen M., Ouédraogo, Jean Bosco, Innovation and Sustainability, Dep of Sustainable Development, Innovation Studies, Guissou, Rosemonde M., Amaratunga, Chanaki, de Haan, Freek, Tou, Fatoumata, Cheah, Phaik Yeong, Yerbanga, R. Serge, Moors, Ellen H.M., Dhorda, Mehul, Tindana, Paulina, Boon, Wouter P.C., Dondorp, Arjen M., and Ouédraogo, Jean Bosco

Published
2023

157. Strategies for deploying triple artemisinin-based combination therapy in the Greater Mekong Subregion

Author

Innovation and Sustainability, Dep of Sustainable Development, Innovation Studies, de Haan, Freek, Amaratunga, Chanaki, Thi, Van Anh Cao, Orng, Long Heng, Vonglokham, Manithong, Quang, Thieu Nguyen, Lek, Dysoley, Boon, Wouter P. C., Dondorp, Arjen M., Moors, Ellen H. M., Innovation and Sustainability, Dep of Sustainable Development, Innovation Studies, de Haan, Freek, Amaratunga, Chanaki, Thi, Van Anh Cao, Orng, Long Heng, Vonglokham, Manithong, Quang, Thieu Nguyen, Lek, Dysoley, Boon, Wouter P. C., Dondorp, Arjen M., and Moors, Ellen H. M.

Published
2023

158. Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study

Author

MS Verloskunde, Cancer, Saito, Makoto, Phyo, Aung Pyae, Chu, Cindy, Proux, Stephane, Rijken, Marcus J, Beau, Candy, Win, Htun Htun, Archasuksan, Laypaw, Wiladphaingern, Jacher, Phu, Nguyen H, Hien, Tran T, Day, Nick P, Dondorp, Arjen M, White, Nicholas J, Nosten, François, McGready, Rose, MS Verloskunde, Cancer, Saito, Makoto, Phyo, Aung Pyae, Chu, Cindy, Proux, Stephane, Rijken, Marcus J, Beau, Candy, Win, Htun Htun, Archasuksan, Laypaw, Wiladphaingern, Jacher, Phu, Nguyen H, Hien, Tran T, Day, Nick P, Dondorp, Arjen M, White, Nicholas J, Nosten, François, and McGready, Rose

Published
2023

160. Numerical Distributions of Parasite Densities During Asymptomatic Malaria

Author

Imwong, Mallika, Stepniewska, Kasia, Tripura, Rupam, Peto, Thomas J., Lwin, Khin Maung, Vihokhern, Benchawan, Wongsaen, Klanarong, von Seidlein, Lorenz, Dhorda, Mehul, Snounou, Georges, Keereecharoen, Lilly, Singhasivanon, Pratap, Sirithiranont, Pasathorn, Chalk, Jem, Nguon, Chea, Day, Nicholas P. J., Nosten, Francois, Dondorp, Arjen, and White, Nicholas J.

Published
2016

161. Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

Author

Abdel Hamid, Muzamil Mahdi, Abdelraheem, Mohamed Hassan, Acheampong, Desmond Omane, Ahouidi, Ambroise, Ali, Mozam, Almagro-Garcia, Jacob, Amambua-Ngwa, Alfred, Amaratunga, Chanaki, Amenga-Etego, Lucas, Andagalu, Ben, Anderson, Tim, Andrianaranjaka, Voahangy, Aniebo, Ifeyinwa, Aninagyei, Enoch, Ansah, Felix, Ansah, Patrick, Apinjoh, Tobias, Arnaldo, Paulo, Ashley, Elizabeth, Auburn, Sarah, Awandare, Gordon, Ba, Hampate, Baraka, Vito, Barry, Alyssa, Bejon, Philip, Bertin, Gwladys, Boni, Maciej, Borrmann, Steffen, Bousema, Teun, Bouyou-Akotet, Marielle, Branch, Oralee, Bull, Peter, Cheah, Huch, Chindavongsa, Keobouphaphone, Chookajorn, Thanat, Chotivanich, Kesinee, Claessens, Antoine, Conway, David, Corredor, Vladimir, Courtier, Erin, Craig, Alister, d'Alessandro, Umberto, Dama, Souleymane, Day, Nicholas, Denis, Brigitte, Dhorda, Mehul, Diakite, Mahamadou, Djimde, Abdoulaye, Dolecek, Christiane, Dondorp, Arjen, Doumbia, Seydou, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego, Egwang, Thomas, Enosse, Sonia Maria Mauricio, Erko, Berhanu, Fairhurst, Rick, Faiz, Abdul, Fanello, Caterina, Fleharty, Mark, Forbes, Matthew, Fukuda, Mark, Gamboa, Dionicia, Ghansah, Anita, Golassa, Lemu, Goncalves, Sonia, Harrison, G, Healy, Sara Anne, Hendry, Jason, Hernandez-Koutoucheva, Anastasia, Hien, Tran Tinh, Hill, Catherine, Hombhanje, Francis, Hott, Amanda, Htut, Ye, Hussein, Mazza, Imwong, Mallika, Ishengoma, Deus, Jackson, Scott, Jacob, Chris, Jeans, Julia, Johnson, Kimberly, Kamaliddin, Claire, Kamau, Edwin, Keatley, Jon, Kochakarn, Theerarat, Konate, Drissa, Konaté, Abibatou, Kone, Aminatou, Kwiatkowski, Dominic, Kyaw, Myat, Kyle, Dennis, Lawniczak, Mara, Lee, Samuel, Lemnge, Martha, Lim, Pharath, Lon, Chanthap, Loua, Kovana, Mandara, Celine, Marfurt, Jutta, Marsh, Kevin, Maude, Richard James, Mayxay, Mayfong, Maïga-Ascofaré, Oumou, Miotto, Olivo, Mita, Toshihiro, Mobegi, Victor, Mohamed, Abdelrahim Osman, Mokuolu, Olugbenga, Montgomery, Jaqui, Morang'A, Collins Misita, Mueller, Ivo, Murie, Kathryn, Newton, Paul, Ngo Duc, Thang, Nguyen, Thuy, Nguyen, Thuy-Nhien, Nguyen Thi Kim, Tuyen, Nguyen Van, Hong, Noedl, Harald, Nosten, François, Noviyanti, Rintis, Ntui, Vincent Ntui-Njock, Nzila, Alexis, Ochola-Oyier, Lynette Isabella, Ocholla, Harold, Oduro, Abraham, Omedo, Irene, Onyamboko, Marie, Ouedraogo, Jean-Bosco, Oyebola, Kolapo, Oyibo, Wellington Aghoghovwia, Pearson, Richard, Peshu, Norbert, Phyo, Aung, Plowe, Christopher, Price, Ric, Pukrittayakamee, Sasithon, Quang, Huynh Hong, Randrianarivelojosia, Milijaona, Rayner, Julian, Ringwald, Pascal, Rosanas-Urgell, Anna, Rovira-Vallbona, Eduard, Ruano-Rubio, Valentin, Ruiz, Lastenia, Saunders, David, Shayo, Alex, Siba, Peter, Simpson, Victoria, Sissoko, Mahamadou, Smith, Christen, Su, Xin-Zhuan, Sutherland, Colin, Takala-Harrison, Shannon, Talman, Arthur, Tavul, Livingstone, Thanh, Ngo Viet, Thathy, Vandana, Thu, Aung Myint, Toure, Mahamoudou, Tshefu, Antoinette, Verra, Federica, Vinetz, Joseph, Wellems, Thomas, Wendler, Jason, White, Nicholas, Whitton, Georgia, Yavo, William, van der Pluijm, Rob, MalariaGEN, University of Khartoum, University of Cape Coast [Ghana], Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), The Wellcome Trust Sanger Institute [Cambridge], London School of Hygiene and Tropical Medicine [Fajara, Gambia], London School of Hygiene and Tropical Medicine (LSHTM), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), West African Centre for Cell Biology of Infectious Pathogens [Legon, Ghana] (WACCBIP), University of Ghana, Navrongo Health Research Centre [Navrongo, Ghana] (NHRC), Kenya Medical Research Institute (KEMRI), Texas Biomedical Research Institute [San Antonio, TX], Université d'Antananarivo, University of Buéa, Instituto Nacional de Saude [Maputo, Mozambique] (INS), Centre for Tropical Medicine and Global Health [Oxford, UK], Nuffield Department of Medicine [Oxford, UK] (Big Data Institute), University of Oxford-University of Oxford, Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Oxford-Mahidol University [Bangkok]-Wellcome Trust, Menzies School of Health Research [Australia], Charles Darwin University [Australia], Nuffield Department of Clinical Medicine [Oxford], University of Oxford, Institut de Recherche pour le Développement (IRD), Laboratory of Pathogen and Host Immunity [Montpellier] (LPHI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), and Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)

Subjects
data resource, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], plasmodium falciparum, genomics, malaria, Medicine (miscellaneous), genomic epidemiology, General Biochemistry, Genetics and Molecular Biology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Contains fulltext : 291985.pdf (Publisher’s version ) (Open Access) We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging crt mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the csp gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.

Published
2023
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163. MORU Tropical Health Network Annual Report 2021

Author

Day, Nicholas, Dondorp, Arjen M, Limmathurotsakul, Direk, Maude, Richard, Tarning, Joel, Cheah, Phaik Yeong, Pan-ngum, Wirichida, White, Nicholas J, Fegan, Greg, Burton, David, Nosten, François, Ashley, Elizabeth A, Turner, Paul, Smithuis, Frank, Newton, Paul N, Fanello, Caterina, Bleho, John, Day, Nicholas P J, Dondorp, Arjen M, Limmathurotsakul, Direk, Maude, Richard, Tarning, Joel, Cheah, Phaik Yeong, Pan-ngum, Wirichida, White, Nicholas J, Fegan, Greg, Burton, David, Nosten, François, Ashley, Elizabeth A., Turner, Paul, Smithuis, Frank, Newton, Paul N, Fanello, Caterina, and Bleho, John

Subjects
Annual report, Medical research, Tropical medicine, MORU
Abstract

2021 Annual Report for the MORU Tropical Health Network, Mahidol Oxford Tropical Medicine Research Unit

Published
2022
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165. The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos

Author

von Seidlein, Lorenz, Peerawaranun, Pimnara, Mukaka, Mavuto, Nosten, Francois H., Nguyen, Thuy-Nhien, Hien, Tran Tinh, Tripura, Rupam, Peto, Thomas J., Pongvongsa, Tiengkham, Phommasone, Koukeo, Mayxay, Mayfong, Imwong, Mallika, Watson, James, Pukrittayakamee, Sasithon, Day, Nicholas P. J., and Dondorp, Arjen M.

Published
2019
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169. Spatiotemporal epidemiology, environmental correlates, and demography of malaria in Tak Province, Thailand (2012–2015)

Author

Mercado, Chris Erwin G., Lawpoolsri, Saranath, Sudathip, Prayuth, Kaewkungwal, Jaranit, Khamsiriwatchara, Amnat, Pan-ngum, Wirichada, Yimsamran, Surapon, Lawawirojwong, Siam, Ho, Kevin, Ekapirat, Nattwut, Maude, Rapeephan R., Wiladphaingern, Jacher, Carrara, Verena I., Day, Nicholas P. J., Dondorp, Arjen M., and Maude, Richard J.

Published
2019
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173. Glucose-6-Phosphate Dehydrogenase (G6PD) Measurement Using Biosensors by Community-Based Village Malaria Workers and Hospital Laboratory Staff in Cambodia: A Quantitative Study

Author

Adhikari, Bipin, primary, Tripura, Rupam, additional, Dysoley, Lek, additional, Peto, Thomas J., additional, Callery, James J., additional, Heng, Chhoeun, additional, Vanda, Thy, additional, Simvieng, Ou, additional, Cassidy-Seyoum, Sarah, additional, Thriemer, Kamala, additional, Dondorp, Arjen M., additional, Ley, Benedikt, additional, and Seidlein, Lorenz von, additional

Published
2023
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174. Author response: Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

Author

Schilling, William HK, primary, Jittamala, Podjanee, primary, Watson, James A, additional, Ekkapongpisit, Maneerat, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Luvira, Viravarn, additional, Pongwilai, Sasithorn, additional, Cruz, Cintia, additional, Callery, James J, additional, Boyd, Simon, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Piaraksa, Nattaporn, additional, Suwannasin, Kanokon, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Sookprome, Sakol, additional, Poovorawan, Kittiyod, additional, Thaipadungpanit, Janjira, additional, Blacksell, Stuart, additional, Imwong, Mallika, additional, Tarning, Joel, additional, Taylor, Walter RJ, additional, Chotivanich, Vasin, additional, Sangketchon, Chunlanee, additional, Ruksakul, Wiroj, additional, Chotivanich, Kesinee, additional, Teixeira, Mauro Martins, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2023
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175. Effectiveness of community engagement among forest goers in a malaria prophylaxis trial: Implementation challenges and implications

Author

Conradis-Jansen, Franca, primary, Tripura, Rupam, additional, Peto, Thomas J, additional, Callery, James J, additional, Adhikari, Bipin, additional, Eam, Mom, additional, Jongdeepaisal, Monnaphat, additional, Pell, Christopher, additional, Khonputsa, Panarasri, additional, Murgia, Riccardo, additional, Sovannaroth, Siv, additional, Müller, Olaf, additional, Cheah, Phaik Yeong, additional, Dondorp, Arjen M, additional, von Seidlein, Lorenz, additional, and Maude, Richard James, additional

Published
2023
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177. Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Author

Kucharski, Michal, primary, Wirjanata, Grennady, additional, Nayak, Sourav, additional, Boentoro, Josephine, additional, Dziekan, Jerzy Michal, additional, Assisi, Christina, additional, van der Pluijm, Rob W., additional, Miotto, Olivo, additional, Mok, Sachel, additional, Dondorp, Arjen M., additional, and Bozdech, Zbynek, additional

Published
2023
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178. Suitability of Low and Middle Income Country Data Derived Prognostics Models for Benchmarking Mortality in a Multinational Asia Critical Care Registry Network

Author

Gamage Dona, Dilanthi, primary, Aryal, Diptesh, additional, Ghose, Aniruddha, additional, Hashmi, Madiha, additional, Nath, Ranjan Kumar, additional, Mat-Nor, Mohd Basri, additional, Thwaites, Louise, additional, Tripathy, Swagata, additional, Kumar Tirupakuzhi Vijavaraghavan, Bharath, additional, Yen, Lam Minh, additional, Dondorp, Arjen M., additional, Haniffa, Rashan, additional, Nirantharakumar, Krishnarajah, additional, Parekh, Dhruv, additional, and Beane, Abigail, additional

Published
2023
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180. Increased intra- and extracellular granzyme expression in patients with tuberculosis

Author

Garcia-Laorden, M. Isabel, Blok, Dana C., Kager, Liesbeth M., Hoogendijk, Arie J., van Mierlo, Gerard J., Lede, Ivar O., Rahman, Wahid, Afroz, Rumana, Ghose, Aniruddha, Visser, Caroline E., Md Zahed, Abu Shahed, Husain, Md Anwar, Alam, Khan Mashrequl, Chandra Barua, Pravat, Hassan, Mahtabuddin, Hossain, Ahmed, Tayab, Md Abu, Day, Nick, Dondorp, Arjen M., de Vos, Alex F., and van der Poll, Tom

Published
2015
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181. A data platform to improve rabies prevention, Sri Lanka/Une plateforme de donnees pour ameliorer la prevention de la rage au Sri Lanka/Una plataforma de datos para mejorar la prevencion de la rabia, Sri Lanka

Author

De Silva, A.Pubudu, Harischandra, P.A. Lionel, Beane, Abi, Rathnayaka, Shriyananda, Pimburage, Ruwini, Wijesiriwardana, Wageesha, Gamage, Dilanthi, Jayasinghe, Desika, Sigera, Chathurani, Gunasekara, Amila, Cadre, Mizaya, Amunugama, Sarath, Athapattu, Priyantha L., Jayasinghe, K.Saroj A., Dondorp, Arjen M., and Haniffa, Rashan

Subjects
Rabies -- Prevention, Health care information services -- Forecasts and trends -- Management, Public health administration -- Analysis, Company business management, Market trend/market analysis, Health
Abstract

Problem In Sri Lanka, rabies prevention initiatives are hindered by fragmented and delayed information-sharing that limits clinicians' ability to follow patients and impedes public health surveillance. Approach In a project led by the health ministry, we adapted existing technologies to create an electronic platform for rabies surveillance. Information is entered by trained clinical staff, and both aggregate and individual patient data are visualized in real time. An automated short message system (SMS) alerts patients for vaccination follow-up appointments and informs public health inspectors about incidents of animal bites. Local setting The platform was rolled out in June 2016 in four districts of Sri Lanka, linking six rabies clinics, three laboratories and the public health inspectorate. Relevant changes Over a 9-month period, 12 121 animal bites were reported to clinics and entered in the registry. Via secure portals, clinicians and public health teams accessed live information on treatment and outcomes of patients started on post- exposure prophylaxis (9507) or receiving deferred treatment (2614). Laboratories rapidly communicated the results of rabies virus tests on dead mammals (328/907 positive). In two pilot districts SMS reminders were sent to 1376 (71.2%) of 1933 patients whose contact details were available. Daily SMS reports alerted 17 public health inspectors to bite incidents in their area for investigation. Lessons learnt Existing technologies in low-resource countries can be harnessed to improve public health surveillance. Investment is needed in platform development and training and support for front-line staff. Greater public engagement is needed to improve completeness of surveillance and treatment. Probleme Au Sri Lanka, les initiatives de prevention de la rage sont entravees par une diffusion des informations fragmentaire et lente, ce qui limite la capacite des cliniciens a suivre les patients et empeche la mise en oeuvre d'une surveillance sanitaire. Approche Dans le cadre d'un projet supervise par le ministere de la Sante, nous avons adapte les technologies existantes afin de creer une plateforme electronique pour la surveillance de la rage. Les informations y sont saisies par du personnel clinique forme, et les donnees de chaque patient ainsi que les donnees globales y sont accessibles en temps reel. Un service automatise de minimessages (SMS) avertit les patients a l'approche de leurs rendez-vous de suivi et de vaccination de rappel et informe les inspecteurs de sante publique des nouveaux cas de morsures d'animaux. Environnement local La plateforme a ete mise en oeuvre en juin 2016 dans quatre districts du Sri Lanka. Elle relie six centres antirabiques, trois laboratoires et l'inspection de la sante publique. Changements significatifs En 9 mois, 12 121 cas de morsures d'animaux ont ete pris en charge par les centres antirabiques et saisis dans le registre. Les cliniciens et les equipes de sante publique ont pu acceder, via des portails securises, a des informations actualisees en direct sur les traitements et l'evolution des patients, suivis dans le cadre d'un traitement prophylactique post-exposition (9507) ou d'un traitement retarde (2614). Les laboratoires ont pu communiquer rapidement les resultats des tests de depistage de la rage realises sur des mammiferes morts (328 cas positifs sur 907). Dans deux districts pilotes correspondant a un total de 1 933 patients pris en charge, des rappels par SMS ont ete envoyes aux 1 376 patients (71,2%) dont les coordonnees de contact etaient connues. Des rapports SMS quotidiens ont permis d'avertir 17 inspecteurs de sante publique de nouveaux cas de morsures survenus dans leur secteur, pour enquete. Lecons tirees Il est possible d'exploiter les technologies existantes, dans les regions a faibles ressources, pour ameliorer la surveillance de la sante publique. Il est encore necessaire d'investir dans le developpement de cette plateforme et dans la formation et I'assistance du personnel de premiere ligne. Une plus grande sensibilisation du public est egalement necessaire pour ameliorer l'exhaustivite de la surveillance et des traitements. Situacion En Sri Lanka, las iniciativas de prevencion de la rabia se ven obstaculizadas por un intercambio de informacion fragmentado y retrasado que limita la capacidad de los medicos de hacer seguimientos a sus pacientes e impide el control de la atencion sanitaria. Enfoque En un proyecto dirigido por el ministerio de sanidad, se adaptaron las tecnologias existentes para crear una plataforma electronica para el control de la rabia. Personal clinico formado introduce la informacion, y los datos sobre pacientes se pueden consultar en tiempo real tanto de forma individual como global. Un sistema automatizado de mensajes cortos (SMS) alerta a los pacientes de citas para vacunas de seguimiento e informa a los Inspectores de salud publica sobre incidentes de mordeduras de animales. Marco regional La plataforma se implemento en junio de 2016 en cuatro distritos de Sri Lanka y vinculo seis clinicas de atencion contra la rabia, tres laboratorios y el cuerpo de inspectores de salud publica. Cambios importantes En un periodo de 9 meses, se informo a las clinicas de 12 121 mordeduras de animales, las cuales fueron inscritas en el registro. A traves de portales seguros, los medicos y los equipos de salud publica accedieron a informacion en directo sobre el tratamiento y los resultados de los pacientes que comenzaron con profilaxis posterior a la exposicion (9 507) o con tratamiento aplazado (2 614). Los laboratorios comunicaron con rapidez los resultados de las pruebas del virus de la rabia en animales muertos (328/907 positivos). En dos distritos piloto, se enviaron recordatorios SMS a 1 376 (71,2%) de los 1 933 pacientes de los que se disponian detalles de contacto. Informes con SMS diarios alertaron a 17 inspectores de salud publica sobre incidentes de mordeduras en su zona para que los investigaran. Lecciones aprendidas Las tecnologias existentes se pueden aprovechar en paises con pocos recursos para mejorar el control de la salud publica. Se necesita invertir en el desarrollo de plataformas y en la formacion y el apoyo del personal de primera linea. Es necesario un mayor compromiso publico para mejorar la finalizacion del control y el tratamiento., Introduction As in many other countries in Africa and Asia, (1) rabies remains a public health problem in Sri Lanka. In 2015, 607 of 1166 animal heads tested positive for [...]

Published
2017
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182. Supplementary materials for 'Mixed methods study protocol for combining stakeholder-led rapid evaluation with near real-time continuous registry data to facilitate evaluations of quality of care in intensive care units'

Author

Rashan, Aasiyah, Beane, Abi, Ghose, Aniruddha, Dondorp, Arjen M, Kwizera, Arthur, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Biccard, Bruce, Righy, Cassia, Thwaites, Louise, Pell, Christopher, Sendagire, Cornelius, Thomson, David, Aryal, Diptesh, Wagstaff, Duncan, Nadia, Farah, Putoto, Giovanni, Paneru, Hem Raj, Udayanga, Ishara, Amuasi, John, Salluh, Jorge, Gokhale, Krishna, Nirantharakumar, Krishnarajah, Pisani, Luigi, Hashmi, Madiha, Schultz, Marcus, Ghalib, Maryam Shamal, Mukaka, Mavuto, Mat-Nor, Mohammed Basri, Siaw-frimpong, Moses, Surenthirakumaran, Rajendra, haniffa, rashan, Kaddu, Ronnie P, Pinto Pereira, Snehal, Murthy, Srinivas, Harris, Steve, Moonesinghe, Suneetha Ramani, Vengadasalam, Sutharshan, Tripathy, Swagata, Gooden, Tiffany, Tolppa, Timo, Pari, Vrindha, Waweru-Siika, Wangari, and Minh, Yen Lam

Abstract

Supplemental materials for article titled 'Mixed methods study protocol for combining stakeholder-led rapid evaluation with near real-time continuous registry data to facilitate evaluations of quality of care in intensive care units'

Published
2023
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183. Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future

Author

Schultz, Marcus J., Dunser, Martin W., Dondorp, Arjen M., Adhikari, Neill K. J., Iyer, Shivakumar, Kwizera, Arthur, and Lubell, Yoel

Subjects
Drug resistance in microorganisms -- Care and treatment, Infection -- Care and treatment, Medical colleges, Epidemiology, Company business management, Health care industry
Abstract

Background Sepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome. Aim To describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics and research aspects of sepsis. We restricted this manuscript to the ICU setting even knowing that many sepsis patients in LMICs are treated outside an ICU. Findings Although many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can sometimes be more important than the response of the host. There are substantial and persisting differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs, but with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and the important differences in resources. Conclusions Addressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for severe sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both at a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement., Author(s): Marcus J. Schultz [sup.1] [sup.2], Martin W. Dunser [sup.3], Arjen M. Dondorp [sup.1] [sup.2], Neill K. J. Adhikari [sup.4], Shivakumar Iyer [sup.5], Arthur Kwizera [sup.6], Yoel Lubell [sup.2], Alfred [...]

Published
2017
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187. Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Author

Takala-Harrison, Shannon, Jacob, Christopher G., Arze, Cesar, Cummings, Michael P., Silva, Joana C., Dondorp, Arjen M., Fukuda, Mark M., Hien, Tran Tinh, Mayxay, Mayfong, Noedl, Harald, Nosten, Francois, Kyaw, Myat P., Nhien, Nguyen Thanh Thuy, Imwong, Mallika, Bethell, Delia, Se, Youry, Lon, Chanthap, Tyner, Stuart D., Saunders, David L., Ariey, Frederic, Mercereau-Puijalon, Odile, Menard, Didier, Newton, Paul N., Khanthavong, Maniphone, Hongvanthong, Bouasy, Starzengruber, Peter, Fuehrer, Hans-Peter, Swoboda, Paul, Khan, Wasif A., Phyo, Aung Pyae, Nyunt, Myaing M., Nyunt, Myat H., Brown, Tyler S., Adams, Matthew, Pepin, Christopher S., Bailey, Jason, Tan, John C., Ferdig, Michael T., Clark, Taane G., Miotto, Olivo, MacInnis, Bronwyn, Kwiatkowski, Dominic P., White, Nicholas J., Ringwald, Pascal, and Plowe, Christopher V.

Published
2015

188. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

Author

Mok, Sachel, Ashley, Elizabeth A., Ferreira, Pedro E., Zhu, Lei, Lin, Zhaoting, Yeo, Tomas, Chotivanich, Kesinee, Imwong, Mallika, Pukrittayakamee, Sasithon, Dhorda, Mehul, Nguon, Chea, Lim, Pharath, Amaratunga, Chanaki, Suon, Seila, Hien, Tran Tinh, Htut, Ye, Faiz, M. Abul, Onyamboko, Marie A., Mayxay, Mayfong, Newton, Paul N., Tripura, Rupam, Woodrow, Charles J., Miotto, Olivo, Kwiatkowski, Dominic P., Nosten, François, Day, Nichoals P. J., Preiser, Peter R., White, Nicholas J., Dondorp, Arjen M., Fairhurst, Rick M., and Bozdech, Zbynek

Published
2015

189. Oscillations in Cerebral Haemodynamics in Patients with Falciparum Malaria

Author

Kolyva, Christina, Kingston, Hugh, Tachtsidis, Ilias, Mohanty, Sanjib, Mishra, Saroj, Patnaik, Rajya, Maude, Richard J., Dondorp, Arjen M., Elwell, Clare E., Back, Nathan, Series Editor, Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Lambris, John D., Series Editor, Paoletti, Rodolfo, Series Editor, Welch, William J., editor, Palm, Fredrik, editor, Bruley, Duane F., editor, and Harrison, David K., editor

Published
2013
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190. The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

Author

Hossain, Mohammad S., Commons, Robert J., Douglas, Nicholas M., Thriemer, Kamala, Alemayehu, Bereket H., Amaratunga, Chanaki, Anvikar, Anupkumar R., Ashley, Elizabeth A., Asih, Puji B. S., Carrara, Verena I., Lon, Chanthap, D'Alessandro, Umberto, Davis, Timothy M. E., Dondorp, Arjen M., Edstein, Michael D., Fairhurst, Rick M., Ferreira, Marcelo U., Hwang, Jimee, Janssens, Bart, Karunajeewa, Harin, Kiechel, Jean R., Ladeia-Andrade, Simone, Laman, Moses, Mayxay, Mayfong, McGready, Rose, Moore, Brioni R., Mueller, Ivo, Newton, Paul N., Thuy-Nhien, Nguyen T., Noedl, Harald, Nosten, Francois, Phyo, Aung P., Poespoprodjo, Jeanne R., Saunders, David L., Smithuis, Frank, Spring, Michele D., Stepniewska, Kasia, Suon, Seila, Suputtamongkol, Yupin, Syafruddin, Din, Tran, Hien T., Valecha, Neena, Van Herp, Michel, Van Vugt, Michele, White, Nicholas J., Guerin, Philippe J., Simpson, Julie A., and Price, Ric N.

Subjects
Malaria -- Drug therapy -- Complications and side effects, Protozoan diseases -- Risk factors, Biological sciences
Abstract

Background There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk and the associated determinants using an individual patient data meta-analysis in order to identify populations in which a policy of universal radical cure, combining artemisinin-based combination therapy (ACT) with a hypnozoitocidal antimalarial drug, would be beneficial. Methods and findings A systematic review of Medline, Embase, Web of Science, and the Cochrane Database of Systematic Reviews identified efficacy studies of uncomplicated falciparum malaria treated with ACT that were undertaken in regions coendemic for P. vivax between 1 January 1960 and 5 January 2018. Data from eligible studies were pooled using standardised methodology. The risk of P. vivax parasitaemia at days 42 and 63 and associated risk factors were investigated by multivariable Cox regression analyses. Study quality was assessed using a tool developed by the Joanna Briggs Institute. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO: CRD42018097400). In total, 42 studies enrolling 15,341 patients were included in the analysis, including 30 randomised controlled trials and 12 cohort studies. Overall, 14,146 (92.2%) patients had P. falciparum monoinfection and 1,195 (7.8%) mixed infection with P. falciparum and P. vivax. The median age was 17.0 years (interquartile range [IQR] = 9.0-29.0 years; range = 0-80 years), with 1,584 (10.3%) patients younger than 5 years. 2,711 (17.7%) patients were treated with artemether-lumefantrine (AL, 13 studies), 651 (4.2%) with artesunate-amodiaquine (AA, 6 studies), 7,340 (47.8%) with artesunate-mefloquine (AM, 25 studies), and 4,639 (30.2%) with dihydroartemisinin-piperaquine (DP, 16 studies). 14,537 patients (94.8%) were enrolled from the Asia-Pacific region, 684 (4.5%) from the Americas, and 120 (0.8%) from Africa. At day 42, the cumulative risk of vivax parasitaemia following treatment of P. falciparum was 31.1% (95% CI 28.9-33.4) after AL, 14.1% (95% CI 10.8-18.3) after AA, 7.4% (95% CI 6.7-8.1) after AM, and 4.5% (95% CI 3.9-5.3) after DP. By day 63, the risks had risen to 39.9% (95% CI 36.6-43.3), 42.4% (95% CI 34.7-51.2), 22.8% (95% CI 21.2-24.4), and 12.8% (95% CI 11.4-14.5), respectively. In multivariable analyses, the highest rate of P. vivax parasitaemia over 42 days of follow-up was in patients residing in areas of short relapse periodicity (adjusted hazard ratio [AHR] = 6.2, 95% CI 2.0-19.5; p = 0.002); patients treated with AL (AHR = 6.2, 95% CI 4.6-8.5; p < 0.001), AA (AHR = 2.3, 95% CI 1.4-3.7; p = 0.001), or AM (AHR = 1.4, 95% CI 1.0-1.9; p = 0.028) compared with DP; and patients who did not clear their initial parasitaemia within 2 days (AHR = 1.8, 95% CI 1.4-2.3; p < 0.001). The analysis was limited by heterogeneity between study populations and lack of data from very low transmission settings. Study quality was high. Conclusions In this meta-analysis, we found a high risk of P. vivax parasitaemia after treatment of P. falciparum malaria that varied significantly between studies. These P. vivax infections are likely attributable to relapses that could be prevented with radical cure including a hypnozoitocidal agent; however, the benefits of such a novel strategy will vary considerably between geographical areas., Author(s): Mohammad S. Hossain 1,2,3,4, Robert J. Commons 1,2,5, Nicholas M. Douglas 2,3, Kamala Thriemer 2, Bereket H. Alemayehu 6, Chanaki Amaratunga 7, Anupkumar R. Anvikar 8, Elizabeth A. Ashley [...]

Published
2020
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191. An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples

Author

Adam, Ishag, Alam, Mohammad Shafiul, Alemu, Sisay, Amaratunga, Chanaki, Amato, Roberto, Andrianaranjaka, Voahangy, Anstey, Nicholas M, Aseffa, Abraham, Ashley, Elizabeth, Assefa, Ashenafi, Auburn, Sarah, Barber, Bridget E, Barry, Alyssa, Batista Pereira, Dhelio, Cao, Jun, Chau, Nguyen Hoang, Chotivanich, Kesinee, Chu, Cindy, Dondorp, Arjen M, Drury, Eleanor, Echeverry, Diego F, Erko, Berhanu, Espino, Fe, Fairhurst, Rick, Faiz, Abdul, Fernanda Villegas, María, Gao, Qi, Golassa, Lemu, Goncalves, Sonia, Grigg, Matthew J, Hamedi, Yaghoob, Hien, Tran Tinh, Htut, Ye, Johnson, Kimberly J, Karunaweera, Nadira, Khan, Wasif, Krudsood, Srivicha, Kwiatkowski, Dominic P, Lacerda, Marcus, Ley, Benedikt, Lim, Pharath, Liu, Yaobao, Llanos-Cuentas, Alejandro, Lon, Chanthap, Lopera-Mesa, Tatiana, Marfurt, Jutta, Michon, Pascal, Miotto, Olivo, Mohammed, Rezika, Mueller, Ivo, Namaik-Larp, Chayadol, Newton, Paul N, Nguyen, Thuy-Nhien, Nosten, Francois, Noviyanti, Rintis, Pava, Zuleima, Pearson, Richard D, Petros, Beyene, Phyo, Aung P, Price, Ric N, Pukrittayakamee, Sasithon, Rahim, Awab Ghulam, Randrianarivelojosia, Milijaona, Rayner, Julian C, Rumaseb, Angela, Siegel, Sasha V, Simpson, Victoria J, Thriemer, Kamala, Tobon-Castano, Alberto, Trimarsanto, Hidayat, Urbano Ferreira, Marcelo, Vélez, Ivan D, Wangchuk, Sonam, Wellems, Thomas E, White, Nicholas J, William, Timothy, Yasnot, Maria F, Yilma, Daniel, Alam, Mohammad Shafiul [0000-0001-8330-5499], Ashley, Elizabeth [0000-0002-7620-4822], Barber, Bridget E [0000-0003-1066-7960], Batista Pereira, Dhelio [0000-0002-7761-5498], Chu, Cindy [0000-0001-9465-8214], Dondorp, Arjen M [0000-0001-5190-2395], Echeverry, Diego F [0000-0003-0301-4478], Espino, Fe [0000-0003-1690-1711], Faiz, Abdul [0000-0002-3460-7535], Golassa, Lemu [0000-0002-1216-8711], Grigg, Matthew J [0000-0001-9914-8352], Karunaweera, Nadira [0000-0003-3985-1817], Kwiatkowski, Dominic P [0000-0002-5023-0176], Ley, Benedikt [0000-0002-5734-0845], Miotto, Olivo [0000-0001-8060-6771], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Pearson, Richard D [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Urbano Ferreira, Marcelo [0000-0002-5293-9090], Wellems, Thomas E [0000-0003-3899-8454], Yasnot, Maria F [0000-0001-8081-4212], Yilma, Daniel [0000-0001-6058-2696], and Apollo - University of Cambridge Repository

Subjects
parasitic diseases, Genomics, Genomic Epidemiology, Plasmodium vivax, Malaria, Data Resource
Abstract

This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr, dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination.

Published
2022

193. Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Author

Mansoor, Rashid, Commons, Robert J, Douglas, Nicholas M, Abuaku, Benjamin, Achan, Jane, Adam, Ishag, Adjei, George O, Adjuik, Martin, Alemayehu, Bereket H, Allan, Richard, Allen, Elizabeth N, Anvikar, Anupkumar R, Arinaitwe, Emmanuel, Ashley, Elizabeth A, Ashurst, Hazel, Asih, Puji BS, Bakyaita, Nathan, Barennes, Hubert, Barnes, Karen I, Basco, Leonardo, Bassat, Quique, Baudin, Elisabeth, Bell, David J, Bethell, Delia, Bjorkman, Anders, Boulton, Caroline, Bousema, Teun, Brasseur, Philippe, Bukirwa, Hasifa, Burrow, Rebekah, Carrara, Verena I, Cot, Michel, D'Alessandro, Umberto, Das, Debashish, Das, Sabyasachi, Davis, Timothy ME, Desai, Meghna, Djimde, Abdoulaye A, Dondorp, Arjen M, Dorsey, Grant, Drakeley, Chris J, Duparc, Stephan, Espie, Emmanuelle, Etard, Jean-Francois, Falade, Catherine, Faucher, Jean Francois, Filler, Scott, Fogg, Carole, Fukuda, Mark, Gaye, Oumar, Genton, Blaise, Rahim, Awab Ghulam, Gilayeneh, Julius, Gonzalez, Raquel, Grais, Rebecca F, Grandesso, Francesco, Greenwood, Brian, Grivoyannis, Anastasia, Hatz, Christoph, Hodel, Eva Maria, Humphreys, Georgina S, Hwang, Jimee, Ishengoma, Deus, Juma, Elizabeth, Kachur, S Patrick, Kager, Piet A, Kamugisha, Erasmus, Kamya, Moses R, Karema, Corine, Kayentao, Kassoum, Kazienga, Adama, Kiechel, Jean-Rene, Kofoed, Poul-Erik, Koram, Kwadwo, Kremsner, Peter G, Lalloo, David G, Laman, Moses, Lee, Sue J, Lell, Bertrand, Maiga, Amelia W, Martensson, Andreas, Mayxay, Mayfong, Mbacham, Wilfred, McGready, Rose, Menan, Herve, Menard, Didier, Mockenhaupt, Frank, Moore, Brioni R, Muller, Olaf, Nahum, Alain, Ndiaye, Jean-Louis, Newton, Paul N, Ngasala, Billy E, Nikiema, Frederic, Nji, Akindeh M, Noedl, Harald, Nosten, Francois, Ogutu, Bernhards R, Ojurongbe, Olusola, Osorio, Lyda, Ouedraogo, Jean-Bosco, Owusu-Agyei, Seth, Pareek, Anil, Penali, Louis K, Piola, Patrice, Plucinski, Mateusz, Premji, Zul, Ramharter, Michael, Richmond, Caitlin L, Rombo, Lars, Rosenthal, Philip J, Salman, Sam, Same-Ekobo, Albert, Sibley, Carol, Sirima, Sodiomon B, Smithuis, Frank M, Some, Fabrice A, Staedke, Sarah G, Starzengruber, Peter, Strub-Wourgaft, Nathalie, Sutanto, Inge, Swarthout, Todd D, Syafruddin, Din, Talisuna, Ambrose O, Taylor, Walter R, Temu, Emmanuel A, Thwing, Julie I, Tinto, Halidou, Tjitra, Emiliana, Toure, Offianan A, Tran, T Hien, Ursing, Johan, Valea, Innocent, Valentini, Giovanni, van Vugt, Michele, von Seidlein, Lorenz, Ward, Stephen A, Were, Vincent, White, Nicholas J, Woodrow, Charles J, Yavo, William, Yeka, Adoke, Zongo, Issaka, Simpson, Julie A, Guerin, Philippe J, Stepniewska, Kasia, Price, Ric N, Roper, Cally, Resistance, WorldWide Antimalarial, WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Group, WorldWide Antimalarial Resistance Network Falciparum Haematology Study, Mansoor, R, Ashley, EA, Ashurst, H, Burrow, R, Carrara, VI, Das, D, Dondorp, AM, Humphreys, GS, Lee, SJ, Mayxay, M, McGready, R, Newton, PN, Nosten, F, Richmond, CL, Sibley, C, Smithuis, FM, Taylor, WR, Tran, TH, von Seidlein, L, White, NJ, Woodrow, CJ, Guerin, PJ, Stepniewska, K, Price, RN, AII - Infectious diseases, Intensive Care Medicine, Infectious diseases, APH - Global Health, and APH - Quality of Care

Subjects
Infectious Medicine, Plasmodium falciparum, wh_120, Infektionsmedicin, Severe anaemia, Parasitemia, wa_530, Antimalarials, Non-artemisinin-based therapy, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, parasitic diseases, qv_256, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Malaria, Falciparum, Child, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Pooled analysis of individual patient data, Anemia, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Artemisinin-based therapy, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Malaria, wc_750, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Haemoglobin
Abstract

Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multivariable logistic regression quantified risk factors for moderately severe anaemia (haemoglobin < 7 g/dL) at day 0, day 3 and day 7 as well as a fractional fall ≥ 25% at day 3 and day 7. Results A total of 70,226 patients, recruited into 200 studies between 1991 and 2013, were included in the analysis: 50,859 (72.4%) enrolled in Africa, 18,451 (26.3%) in Asia and 916 (1.3%) in South America. The median haemoglobin concentration at presentation was 9.9 g/dL (range 5.0–19.7 g/dL) in Africa, 11.6 g/dL (range 5.0–20.0 g/dL) in Asia and 12.3 g/dL (range 6.9–17.9 g/dL) in South America. Moderately severe anaemia (Hb < 7g/dl) was present in 8.4% (4284/50,859) of patients from Africa, 3.3% (606/18,451) from Asia and 0.1% (1/916) from South America. The nadir haemoglobin occurred on day 2 post treatment with a mean fall from baseline of 0.57 g/dL in Africa and 1.13 g/dL in Asia. Independent risk factors for moderately severe anaemia on day 7, in both Africa and Asia, included moderately severe anaemia at baseline (adjusted odds ratio (AOR) = 16.10 and AOR = 23.00, respectively), young age (age < 1 compared to ≥ 12 years AOR = 12.81 and AOR = 6.79, respectively), high parasitaemia (AOR = 1.78 and AOR = 1.58, respectively) and delayed parasite clearance (AOR = 2.44 and AOR = 2.59, respectively). In Asia, patients treated with an artemisinin-based regimen were at significantly greater risk of moderately severe anaemia on day 7 compared to those treated with a non-artemisinin-based regimen (AOR = 2.06 [95%CI 1.39–3.05], p < 0.001). Conclusions In patients with uncomplicated P. falciparum malaria, the nadir haemoglobin occurs 2 days after starting treatment. Although artemisinin-based treatments increase the rate of parasite clearance, in Asia they are associated with a greater risk of anaemia during recovery.

Published
2022
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194. A framework for stakeholder engagement in the adoption of new antimalarial treatments in Africa: a case study of Nigeria

Author

Mokuolu, Olugbenga Ayodeji, primary, Bolarinwa, Oladimeji Akeem, additional, Opadiran, Oluwatumobi Racheal, additional, Ameen, Hafsat Abolore, additional, Dhorda, Mehul, additional, Cheah, Phaik Yeong, additional, Amaratunga, Chanaki, additional, Haan, Freek, additional, Tindana, Paulina, additional, and Dondorp, Arjen M., additional

Published
2022
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195. Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries

Author

Srisutham, Suttipat, primary, Madmanee, Wanassanan, additional, Kouhathong, Jindarat, additional, Sutawong, Kreepol, additional, Tripura, Rupam, additional, Peto, Thomas J., additional, van der Pluijm, Rob W., additional, Callery, James J., additional, Dysoley, Lek, additional, Mayxay, Mayfong, additional, Newton, Paul N., additional, Pongvongsa, Tiengkham, additional, Hongvanthong, Bouasy, additional, Day, Nicholas P. J., additional, White, Nicholas J., additional, Dondorp, Arjen M., additional, and Imwong, Mallika, additional

Published
2022
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196. Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial

Author

Wamae, Kevin, primary, Ndwiga, Leonard, additional, Kharabora, Oksana, additional, Kimenyi, Kelvin, additional, Osoti, Victor, additional, de Laurent, Zaydah, additional, Wambua, Juliana, additional, Musyoki, Jennifer, additional, Ngetsa, Caroline, additional, Kalume, Peter, additional, Mwambingu, Gabriel, additional, Hamaluba, Mainga, additional, van der Pluijm, Rob, additional, Dondorp, Arjen M., additional, Bailey, Jeffrey, additional, Juliano, Jonathan, additional, Bejon, Philip, additional, and Ochola-Oyier, Lynette, additional

Published
2022
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197. Malaria outbreak in Laos driven by a selective sweep for Plasmodium falciparum kelch13 R539T mutants: a genetic epidemiology analysis

Author

Wasakul, Varanya, primary, Disratthakit, Areeya, additional, Mayxay, Mayfong, additional, Chindavongsa, Keobouphaphone, additional, Sengsavath, Viengphone, additional, Thuy-Nhien, Nguyen, additional, Pearson, Richard D, additional, Phalivong, Sonexay, additional, Xayvanghang, Saiamphone, additional, Maude, Richard J, additional, Gonçalves, Sónia, additional, Day, Nicholas P, additional, Newton, Paul N, additional, Ashley, Elizabeth A, additional, Kwiatkowski, Dominic P, additional, Dondorp, Arjen M, additional, and Miotto, Olivo, additional

Published
2022
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199. Clinical antiviral efficacy of remdesivir and casirivimab/imdevimab against the SARS-CoV-2 Delta and Omicron variants

Author

Jittamala, Podjanee, primary, Schilling, William HK, additional, Watson, James A, additional, Luvira, Viravarn, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Almeida, Pedro J, additional, Ekkapongpisit, Maneerat, additional, Cruz, Cintia, additional, Callery, James J, additional, Boyd, Simon, additional, Anunsittichai, Orawan, additional, Hongsuwan, Maliwan, additional, Singhaboot, Yutatirat, additional, Pagornrat, Watcharee, additional, Tuntipaiboontana, Runch, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Keayarsa, Srisuda, additional, Madmanee, Wanassanan, additional, Aguiar, Renato S, additional, Santos, Franciele M, additional, Batty, Elizabeth M, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Sookprome, Sakol, additional, Poovorawan, Kittiyod, additional, Imwong, Mallika, additional, Taylor, Walter RJ, additional, Chotivanich, Vasin, additional, Sangketchon, Chunlanee, additional, Ruksakul, Wiroj, additional, Chotivanich, Kesinee, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas PJ, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2022
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