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158. Monitoring the Official YouTube Channels of E-Cigarette Companies: A Thematic Analysis

Author

Donaldson, Scott I., Dormanesh, Allison, Perez, Cindy, Zaffer, Muhammad O., Majmundar, Anuja, Unger, Jennifer B., and Allem, Jon-Patrick

Abstract

Background: E-cigarette companies use YouTube to foster brand awareness, market their products, and interact with current and future tobacco users. However, research on the official YouTube channels of e-cigarette companies is limited. This study determined the themes of, and degree of user engagement with, videos posted to the official channels of e-cigarette companies on YouTube. Methods: Data were collected from the official YouTube channels of seven e-cigarette companies by scraping (i.e., electronically copying) the videos. The earliest video was posted on October 10, 2013, and the most recent video was posted on April 22, 2021 (n = 260). An inductive approach was used to identify themes in the data. User engagement with posts including number of likes, dislikes, and comments were also collected. Results: Prevalent themes included branding (n = 250 of 260 videos, 96%), youth use (n = 222, 85%), and tobacco use (n = 210, 81%), while less common themes included misleading health statements (n = 4, 2%), personal choice (n = 4, 2%), and antitobacco (n = 2, 1%). Videos that contained the themes testimonial, product design features, and instructional received the highest mean number of likes. Videos that contained the themes antitobacco, cessation, and testimonial received the highest mean number of dislikes. The 260 videos in this study were collectively viewed 6,619,700 times as of May 5, 2021. Conclusions: Videos from the official YouTube channels of seven e-cigarette companies often focused on branding and user experience but rarely mentioned cessation. While videos about cessation were rare, they received the second highest mean number of dislikes. Future research should assess the impact of exposure to e-cigarette-related content on YouTube and e-cigarette-related attitudes and behaviors.

Published
2023
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159. Half Title Page, Title Page, Copyright

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

160. Cover

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

161. Afterword

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

162. The Army Would Soon Grow Accustomed to It

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

163. Image Plates

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

164. Bibliographic Essay

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

165. Index

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

166. A Brief Moment in the Sun

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

167. A Nursery of Treason Remade?

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

168. Trying Times on the Hudson

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

169. The First African American Cadets at West Point

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

172. Making West Point All-American

Author

Donaldson, Le'Trice D., Nagel, Amanda M., Bratten, Jonathan D., McGovern, Rory, Machoian, Ronald G., Koebrich, Louisa, Campbell, Makonen, McCoy, Cameron D., and Domby, Adam H.

Published
2024

173. Fetal alcohol spectrum disorders prevention and clinical guidelines research - workshop report

Author

Tracey Pérez Koehlmoos, Elizabeth Lee, Ilse Rivera, Jennifer Wisdahl, Katie Erdman, and Tom Donaldson

Subjects
Fetal Alcohol Spectrum Disorders, FASD, Prenatal alcohol exposure, Military Health System, Medicine, Science
Abstract

Abstract It is estimated that up to 1 in 20 people in the United States may have a fetal alcohol spectrum disorder (FASD), or the array of physical, cognitive, emotional, and social disorders caused by exposure to alcohol during prenatal development (May et al., JAMA 319:474–82, 2018). While this condition is present in a broad range of individuals and families, it has not previously been examined in the military community, where cultural factors including an increased prevalence of alcohol misuse may pose a unique set of challenges (Health.mil, Alcohol misuse, 2024). The Uniformed Services University of the Health Sciences (USUHS), in conjunction with FASD United, hosted the second annual Workshop on Fetal Alcohol Spectrum Disorders Prevention and Clinical Guidelines Research on 20 September 2023 in Washington, DC. Organized as part of a four-year, federally-funded health services research initiative on FASD in the U.S. Department of Defense (DoD) Military Health System (MHS), the workshop provided a forum for exploring the initiative’s focus and progress; examining current knowledge and practice in the research and clinical spheres; and identifying potential strategies to further improve prevention, screening, diagnosis, interventions, and family support. Building off of the 2022 workshop that covered the state of the science surrounding prenatal alcohol exposure and FASD, the 2023 focused primarily on FASD and efforts aimed at identification and management (Koehlmoos et al., BMC Proc 17 Suppl 12:19, 2023). One hundred and thirty attendees from academia, healthcare, federal agencies, and patient advocacy organizations gathered to share research findings; learn from lived experiences; and discuss initiatives to advance research, screening, and services for at-risk pregnant women as well as families and caregivers supporting individuals with FASD.

Published
2024
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174. Predicting the magnitude and timing of peak electricity demand: A competition case study

Author

Daniel L. Donaldson, Jethro Browell, and Ciaran Gilbert

Subjects
artificial intelligence and data analytics, load forecasting, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Abstract As weather dependence of the electricity network grows, there is an increasing need to predict the time at which the network peak load will occur. Improving forecasts of peak hour can lead to more accurate scheduling of generation as well as the ability to use flexibility to improve system utilisation or defer capital investment. While there are extensive benchmark models for forecasting electricity demand, their efficacy at forecasting the time or shape of the peak remains to be seen. Global forecasting competitions provide a unique opportunity to compare multiple methodologies under common performance criteria and incentives. The methodology and results are detailed from the Big Data and Energy Analytics Laboratory Challenge 2022 used by the team ‘peaky‐finders’ and investigates the suitability of using hourly methods to forecast daily peak magnitude, time, and shape. The resulting approach provides a reproducible ensemble benchmark against which to evaluate more complex methods. Results indicate that simple regression techniques can perform well and outperform more complicated methods during seasons with low hourly variability, however ensemble methods show higher accuracy overall. The results also highlight the significant impact of extreme weather on forecast accuracy, demonstrating the importance of forecasting processes that are resilient to extreme weather.

Published
2024
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175. Search for leptoquark pair production decaying into $$te^- \bar{t}e^+$$ t e - t ¯ e + or $$t\mu ^- \bar{t}\mu ^+$$ t μ - t ¯ μ + in multi-lepton final states in pp collisions at $$\sqrt{s} = 13\,\textrm{TeV}$$ s = 13 TeV with the ATLAS detector

Author

ATLAS Collaboration, G. Aad, B. Abbott, D. C. Abbott, K. Abeling, S. H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, A. C. Abusleme Hoffman, B. S. Acharya, B. Achkar, C. Adam Bourdarios, L. Adamczyk, L. Adamek, S. V. Addepalli, J. Adelman, A. Adiguzel, S. Adorni, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, J. A. Aguilar-Saavedra, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, I. Aizenberg, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, S. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, A. Alfonsi, F. Alfonsi, M. Alhroob, B. Ali, S. Ali, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, E. Alunno Camelia, M. Alvarez Estevez, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, S. P. Amor Dos Santos, S. Amoroso, K. R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, D. J. A. Antrim, F. Anulli, M. Aoki, T. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella, C. Appelt, N. Aranzabal, V. Araujo Ferraz, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, A. J. Armbruster, O. Arnaez, H. Arnold, Z. P. Arrubarrena Tame, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, K. Assamagan, R. Astalos, R. J. Atkin, M. Atkinson, N. B. Atlay, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avner, G. Avolio, K. Axiotis, M. K. Ayoub, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, P. Bagnaia, M. Bahmani, A. J. Bailey, V. R. Bailey, J. T. Baines, C. Bakalis, O. K. Baker, P. J. Bakker, E. Bakos, D. Bakshi Gupta, S. Balaji, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, G. Barbour, K. N. Barends, T. Barillari, M-S. Barisits, T. Barklow, R. M. Barnett, P. Baron, D. A. Baron Moreno, A. Baroncelli, G. Barone, A. J. Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartos, A. Basalaev, A. Basan, M. Baselga, I. Bashta, A. Bassalat, M. J. Basso, C. R. Basson, R. L. Bates, S. Batlamous, J. R. Batley, B. Batool, M. Battaglia, D. Battulga, M. Bauce, P. Bauer, A. Bayirli, J. B. Beacham, T. Beau, P. H. Beauchemin, F. Becherer, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, C. Beirao Da Cruz E Silva, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, K. Belotskiy, N. L. Belyaev, D. Benchekroun, F. Bendebba, Y. Benhammou, D. P. Benjamin, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, S. Berlendis, G. Bernardi, C. Bernius, F. U. Bernlochner, T. Berry, P. Berta, A. Berthold, I. A. Bertram, S. Bethke, A. Betti, A. J. Bevan, M. Bhamjee, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, V. S. Bhopatkar, R. Bi, R. M. Bianchi, O. Biebel, R. Bielski, M. Biglietti, T. R. V. Billoud, M. Bindi, A. Bingul, C. Bini, S. Biondi, A. Biondini, C. J. Birch-sykes, G. A. Bird, M. Birman, T. Bisanz, E. Bisceglie, D. Biswas, A. Bitadze, K. Bjørke, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, J. Blumenthal, G. J. Bobbink, V. S. Bobrovnikov, M. Boehler, D. Bogavac, A. G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C. D. Booth, A. G. Borbély, H. M. Borecka-Bielska, L. S. Borgna, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J. D. Bossio Sola, K. Bouaouda, N. Bouchhar, J. Boudreau, E. V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I. R. Boyko, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J. E. Brau, K. Brendlinger, R. Brener, L. Brenner, R. Brenner, S. Bressler, B. Brickwedde, D. Britton, D. Britzger, I. Brock, G. Brooijmans, W. K. Brooks, E. Brost, T. L. Bruckler, P. A. Bruckman de Renstrom, B. Brüers, D. Bruncko, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, L. Bryngemark, T. Buanes, Q. Buat, P. Buchholz, A. G. Buckley, I. A. Budagov, M. K. Bugge, O. Bulekov, B. A. Bullard, S. Burdin, C. D. Burgard, A. M. Burger, B. Burghgrave, J. T. P. Burr, C. D. Burton, J. C. Burzynski, E. L. Busch, V. Büscher, P. J. Bussey, J. M. Butler, C. M. Buttar, J. M. Butterworth, W. Buttinger, C. J. Buxo Vazquez, A. R. Buzykaev, G. Cabras, S. Cabrera Urbán, D. Caforio, H. Cai, Y. Cai, V. M. M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L. P. Caloba, D. Calvet, S. Calvet, T. P. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M. T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A. Canesse, M. Cano Bret, J. Cantero, Y. Cao, F. Capocasa, M. Capua, A. Carbone, R. Cardarelli, J. C. J. Cardenas, F. Cardillo, T. Carli, G. Carlino, J. I. Carlotto, B. T. Carlson, E. M. Carlson, L. Carminati, M. Carnesale, S. Caron, E. Carquin, S. Carrá, G. Carratta, F. Carrio Argos, J. W. S. Carter, T. M. Carter, M. P. Casado, A. F. Casha, E. G. Castiglia, F. L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N. F. Castro, A. Catinaccio, J. R. Catmore, V. Cavaliere, N. Cavalli, V. Cavasinni, E. Celebi, F. Celli, M. S. Centonze, K. Cerny, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, A. Cervelli, S. A. Cetin, Z. Chadi, D. Chakraborty, M. Chala, J. Chan, W. Y. Chan, J. D. Chapman, B. Chargeishvili, D. G. Charlton, T. P. Charman, M. Chatterjee, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, S. Chen, S. J. Chen, X. Chen, Y. Chen, C. L. Cheng, H. C. Cheng, S. Cheong, A. Cheplakov, E. Cheremushkina, E. Cherepanova, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, N. Chiedde, G. Chiodini, A. S. Chisholm, A. Chitan, M. Chitishvili, Y. H. Chiu, M. V. Chizhov, K. Choi, A. R. Chomont, Y. Chou, E. Y. S. Chow, T. Chowdhury, L. D. Christopher, K. L. Chu, M. C. Chu, X. Chu, J. Chudoba, J. J. Chwastowski, D. Cieri, K. M. Ciesla, V. Cindro, A. Ciocio, F. Cirotto, Z. H. Citron, M. Citterio, D. A. Ciubotaru, B. M. Ciungu, A. Clark, P. J. Clark, J. M. Clavijo Columbie, S. E. Clawson, C. Clement, J. Clercx, Y. Coadou, M. Cobal, A. Coccaro, R. F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, H. Cohen, A. E. C. Coimbra, B. Cole, J. Collot, P. Conde Muiño, M. P. Connell, S. H. Connell, I. A. Connelly, E. I. Conroy, F. Conventi, H. G. Cooke, A. M. Cooper-Sarkar, F. Cormier, L. D. Corpe, M. Corradi, E. E. Corrigan, F. Corriveau, A. Cortes-Gonzalez, M. J. Costa, F. Costanza, D. Costanzo, B. M. Cote, G. Cowan, J. W. Cowley, K. Cranmer, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, M. Cristoforetti, V. Croft, G. Crosetti, A. Cueto, T. Cuhadar Donszelmann, H. Cui, Z. Cui, A. R. Cukierman, W. R. Cunningham, F. Curcio, P. Czodrowski, M. M. Czurylo, M. J. Da Cunha Sargedas De Sousa, J. V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, C. Dallapiccola, M. Dam, G. D’amen, V. D’Amico, J. Damp, J. R. Dandoy, M. F. Daneri, M. Danninger, V. Dao, G. Darbo, S. Darmora, S. J. Das, S. D’Auria, C. David, T. Davidek, D. R. Davis, B. Davis-Purcell, I. Dawson, K. De, R. De Asmundis, M. De Beurs, N. De Biase, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, A. De Salvo, U. De Sanctis, A. De Santo, J. B. De Vivie De Regie, D. V. Dedovich, J. Degens, A. M. Deiana, F. Del Corso, J. Del Peso, F. Del Rio, F. Deliot, C. M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell’Acqua, L. Dell’Asta, M. Delmastro, P. A. Delsart, S. Demers, M. Demichev, S. P. Denisov, L. D’Eramo, D. Derendarz, F. Derue, P. Dervan, K. Desch, K. Dette, C. Deutsch, P. O. Deviveiros, F. A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, A. Di Domenico, C. Di Donato, A. Di Girolamo, G. Di Gregorio, A. Di Luca, B. Di Micco, R. Di Nardo, C. Diaconu, F. A. Dias, T. Dias Do Vale, M. A. Diaz, F. G. Diaz Capriles, M. Didenko, E. B. Diehl, L. Diehl, S. Díez Cornell, C. Diez Pardos, C. Dimitriadi, A. Dimitrievska, W. Ding, J. Dingfelder, I-M. Dinu, S. J. Dittmeier, F. Dittus, F. Djama, T. Djobava, J. I. Djuvsland, C. Doglioni, J. Dolejsi, Z. Dolezal, M. Donadelli, B. Dong, J. Donini, A. D’Onofrio, M. D’Onofrio, J. Dopke, A. Doria, M. T. Dova, A. T. Doyle, M. A. Draguet, E. Drechsler, E. Dreyer, I. Drivas-koulouris, A. S. Drobac, M. Drozdova, D. Du, T. A. du Pree, F. Dubinin, M. Dubovsky, E. Duchovni, G. Duckeck, O. A. Ducu, D. Duda, A. Dudarev, M. D’uffizi, L. Duflot, M. Dührssen, C. Dülsen, A. E. Dumitriu, M. Dunford, S. Dungs, K. Dunne, A. Duperrin, H. Duran Yildiz, M. Düren, A. Durglishvili, B. L. Dwyer, G. I. Dyckes, M. Dyndal, S. Dysch, B. S. Dziedzic, Z. O. Earnshaw, B. Eckerova, M. G. Eggleston, E. Egidio Purcino De Souza, L. F. Ehrke, G. Eigen, K. Einsweiler, T. Ekelof, P. A. Ekman, Y. El Ghazali, H. El Jarrari, A. El Moussaouy, V. Ellajosyula, M. Ellert, F. Ellinghaus, A. A. Elliot, N. Ellis, J. Elmsheuser, M. Elsing, D. Emeliyanov, A. Emerman, Y. Enari, I. Ene, S. Epari, J. Erdmann, A. Ereditato, P. A. Erland, M. Errenst, M. Escalier, C. Escobar, E. Etzion, G. Evans, H. Evans, M. O. Evans, A. Ezhilov, S. Ezzarqtouni, F. Fabbri, L. Fabbri, G. Facini, V. Fadeyev, R. M. Fakhrutdinov, S. Falciano, P. J. Falke, S. Falke, J. Faltova, Y. Fan, Y. Fang, G. Fanourakis, M. Fanti, M. Faraj, Z. Farazpay, A. Farbin, A. Farilla, T. Farooque, S. M. Farrington, F. Fassi, D. Fassouliotis, M. Faucci Giannelli, W. J. Fawcett, L. Fayard, P. Federicova, O. L. Fedin, G. Fedotov, M. Feickert, L. Feligioni, A. Fell, D. E. Fellers, C. Feng, M. Feng, Z. Feng, M. J. Fenton, A. B. Fenyuk, L. Ferencz, S. W. Ferguson, J. Ferrando, A. Ferrari, P. Ferrari, R. Ferrari, D. Ferrere, C. Ferretti, F. Fiedler, A. Filipčič, E. K. Filmer, F. Filthaut, M. C. N. Fiolhais, L. Fiorini, F. Fischer, W. C. Fisher, T. Fitschen, I. Fleck, P. Fleischmann, T. Flick, L. Flores, M. Flores, L. R. Flores Castillo, F. M. Follega, N. Fomin, J. H. Foo, B. C. Forland, A. Formica, A. C. Forti, E. Fortin, A. W. Fortman, M. G. Foti, L. Fountas, D. Fournier, H. Fox, P. Francavilla, S. Francescato, S. Franchellucci, M. Franchini, S. Franchino, D. Francis, L. Franco, L. Franconi, M. Franklin, G. Frattari, A. C. Freegard, P. M. Freeman, W. S. Freund, N. Fritzsche, A. Froch, D. Froidevaux, J. A. Frost, Y. Fu, M. Fujimoto, E. Fullana Torregrosa, J. Fuster, A. Gabrielli, P. Gadow, G. Gagliardi, L. G. Gagnon, G. E. Gallardo, E. J. Gallas, B. J. Gallop, R. Gamboa Goni, K. K. Gan, S. Ganguly, J. Gao, Y. Gao, F. M. Garay Walls, B. Garcia, C. García, J. E. García Navarro, J. A. García Pascual, M. Garcia-Sciveres, R. W. Gardner, D. Garg, R. B. Garg, S. Gargiulo, C. A. Garner, V. Garonne, S. J. Gasiorowski, P. Gaspar, G. Gaudio, V. Gautam, P. Gauzzi, I. L. Gavrilenko, A. Gavrilyuk, C. Gay, G. Gaycken, E. N. Gazis, A. A. Geanta, C. M. Gee, J. Geisen, M. Geisen, C. Gemme, M. H. Genest, S. Gentile, S. George, W. F. George, T. Geralis, L. O. Gerlach, P. Gessinger-Befurt, M. Ghasemi Bostanabad, M. Ghneimat, K. Ghorbanian, A. Ghosal, A. Ghosh, B. Giacobbe, S. Giagu, N. Giangiacomi, P. Giannetti, A. Giannini, S. M. Gibson, M. Gignac, D. T. Gil, A. K. Gilbert, B. J. Gilbert, D. Gillberg, G. Gilles, N. E. K. Gillwald, L. Ginabat, D. M. Gingrich, M. P. Giordani, P. F. Giraud, G. Giugliarelli, D. Giugni, F. Giuli, I. Gkialas, L. K. Gladilin, C. Glasman, G. R. Gledhill, M. Glisic, I. Gnesi, Y. Go, M. Goblirsch-Kolb, B. Gocke, D. Godin, S. 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P. Rapheeha, V. Raskina, D. F. Rassloff, S. Rave, B. Ravina, I. Ravinovich, M. Raymond, A. L. Read, N. P. Readioff, D. M. Rebuzzi, G. Redlinger, K. Reeves, J. A. Reidelsturz, D. Reikher, A. Reiss, A. Rej, C. Rembser, A. Renardi, M. Renda, M. B. Rendel, F. Renner, A. G. Rennie, S. Resconi, M. Ressegotti, E. D. Resseguie, S. Rettie, J. G. Reyes Rivera, B. Reynolds, E. Reynolds, M. Rezaei Estabragh, O. L. Rezanova, P. Reznicek, E. Ricci, R. Richter, S. Richter, E. Richter-Was, M. Ridel, P. Rieck, P. Riedler, M. Rijssenbeek, A. Rimoldi, M. Rimoldi, L. Rinaldi, T. T. Rinn, M. P. Rinnagel, G. Ripellino, I. Riu, P. Rivadeneira, J. C. Rivera Vergara, F. Rizatdinova, E. Rizvi, C. Rizzi, B. A. Roberts, B. R. Roberts, S. H. Robertson, M. Robin, D. Robinson, C. M. Robles Gajardo, M. Robles Manzano, A. Robson, A. Rocchi, C. Roda, S. Rodriguez Bosca, Y. Rodriguez Garcia, A. Rodriguez Rodriguez, A. M. Rodríguez Vera, S. Roe, J. T. Roemer, A. R. Roepe-Gier, J. Roggel, O. Røhne, R. A. Rojas, B. Roland, C. P. A. Roland, J. Roloff, A. Romaniouk, E. Romano, M. Romano, A. C. Romero Hernandez, N. Rompotis, L. Roos, S. Rosati, B. J. Rosser, E. Rossi, L. P. Rossi, L. Rossini, R. Rosten, M. Rotaru, B. Rottler, D. Rousseau, D. Rousso, G. Rovelli, A. Roy, A. Rozanov, Y. Rozen, X. Ruan, A. Rubio Jimenez, A. J. Ruby, V. H. Ruelas Rivera, T. A. Ruggeri, F. Rühr, A. Ruiz-Martinez, A. Rummler, Z. Rurikova, N. A. Rusakovich, H. L. Russell, J. P. Rutherfoord, K. Rybacki, M. Rybar, E. B. Rye, A. Ryzhov, J. A. Sabater Iglesias, P. Sabatini, L. Sabetta, H.F-W. Sadrozinski, F. Safai Tehrani, B. Safarzadeh Samani, M. Safdari, S. Saha, M. Sahinsoy, M. Saimpert, M. Saito, T. Saito, D. Salamani, G. Salamanna, A. Salnikov, J. Salt, A. Salvador Salas, D. Salvatore, F. Salvatore, A. Salzburger, D. Sammel, D. Sampsonidis, D. Sampsonidou, J. Sánchez, A. Sanchez Pineda, V. Sanchez Sebastian, H. Sandaker, C. O. Sander, J. A. Sandesara, M. Sandhoff, C. Sandoval, D. P. C. Sankey, A. Sansoni, L. Santi, C. Santoni, H. Santos, S. N. Santpur, A. Santra, K. A. Saoucha, J. G. Saraiva, J. Sardain, O. Sasaki, K. Sato, C. Sauer, F. Sauerburger, E. Sauvan, P. Savard, R. Sawada, C. Sawyer, L. Sawyer, I. Sayago Galvan, C. Sbarra, A. Sbrizzi, T. Scanlon, J. Schaarschmidt, P. Schacht, D. Schaefer, U. Schäfer, A. C. Schaffer, D. Schaile, R. D. Schamberger, E. Schanet, C. Scharf, M. M. Schefer, V. A. Schegelsky, D. Scheirich, F. Schenck, M. Schernau, C. Scheulen, C. Schiavi, Z. M. Schillaci, E. J. Schioppa, M. Schioppa, B. Schlag, K. E. Schleicher, S. Schlenker, J. Schmeing, M. A. Schmidt, K. Schmieden, C. Schmitt, S. Schmitt, L. Schoeffel, A. Schoening, P. G. Scholer, E. Schopf, M. Schott, J. Schovancova, S. Schramm, F. Schroeder, H-C. Schultz-Coulon, M. Schumacher, B. A. Schumm, Ph. Schune, A. Schwartzman, T. A. Schwarz, Ph. Schwemling, R. Schwienhorst, A. Sciandra, G. Sciolla, F. Scuri, F. Scutti, C. D. Sebastiani, K. Sedlaczek, P. Seema, S. C. Seidel, A. Seiden, B. D. Seidlitz, T. Seiss, C. Seitz, J. M. Seixas, G. Sekhniaidze, S. J. Sekula, L. Selem, N. Semprini-Cesari, S. Sen, D. Sengupta, V. Senthilkumar, L. Serin, L. Serkin, M. Sessa, H. Severini, S. Sevova, F. Sforza, A. Sfyrla, E. Shabalina, R. Shaheen, J. D. Shahinian, D. Shaked Renous, L. Y. Shan, M. Shapiro, A. Sharma, A. S. Sharma, P. Sharma, S. Sharma, P. B. Shatalov, K. Shaw, S. M. Shaw, Q. Shen, P. Sherwood, L. Shi, C. O. Shimmin, Y. Shimogama, J. D. Shinner, I. P. J. Shipsey, S. Shirabe, M. Shiyakova, J. Shlomi, M. J. Shochet, J. Shojaii, D. R. Shope, S. Shrestha, E. M. Shrif, M. J. Shroff, P. Sicho, A. M. Sickles, E. Sideras Haddad, A. Sidoti, F. Siegert, Dj. Sijacki, R. Sikora, F. Sili, J. M. Silva, M. V. Silva Oliveira, S. B. Silverstein, S. Simion, R. Simoniello, E. L. Simpson, N. D. Simpson, S. Simsek, S. Sindhu, P. Sinervo, V. Sinetckii, S. Singh, S. Sinha, M. Sioli, I. Siral, S.Yu. Sivoklokov, J. Sjölin, A. Skaf, E. Skorda, P. Skubic, M. Slawinska, V. Smakhtin, B. H. Smart, J. Smiesko, S.Yu. Smirnov, Y. Smirnov, L. N. Smirnova, O. Smirnova, A. C. Smith, E. A. Smith, H. A. Smith, J. L. Smith, R. Smith, M. Smizanska, K. Smolek, A. Smykiewicz, A. A. Snesarev, H. L. Snoek, S. Snyder, R. Sobie, A. Soffer, C. A. Solans Sanchez, E.Yu. Soldatov, U. Soldevila, A. A. Solodkov, S. Solomon, A. Soloshenko, K. Solovieva, O. V. Solovyanov, V. Solovyev, P. Sommer, A. Sonay, W. Y. Song, A. Sopczak, A. L. Sopio, F. Sopkova, V. Sothilingam, S. Sottocornola, R. Soualah, Z. Soumaimi, D. South, S. Spagnolo, M. Spalla, F. Spanò, D. Sperlich, G. Spigo, M. Spina, S. Spinali, D. P. Spiteri, M. Spousta, E. J. Staats, A. Stabile, R. Stamen, M. Stamenkovic, A. Stampekis, M. Standke, E. Stanecka, M. V. Stange, B. Stanislaus, M. M. Stanitzki, M. Stankaityte, B. Stapf, E. A. Starchenko, G. H. Stark, J. Stark, D. M. Starko, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, G. Stavropoulos, J. Steentoft, P. Steinberg, A. L. Steinhebel, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T. J. Stevenson, G. A. Stewart, M. C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Strauss, T. Strebler, P. Strizenec, R. Ströhmer, D. M. Strom, L. R. Strom, R. Stroynowski, A. Strubig, S. A. Stucci, B. Stugu, J. Stupak, N. A. Styles, D. Su, S. Su, W. Su, X. Su, K. Sugizaki, V. V. Sulin, M. J. Sullivan, D. M. S. Sultan, L. Sultanaliyeva, S. Sultansoy, T. Sumida, S. Sun, O. Sunneborn Gudnadottir, M. R. Sutton, M. Svatos, M. Swiatlowski, T. Swirski, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, J. S. Tafoya Vargas, R. H. M. Taibah, R. Takashima, K. Takeda, E. P. Takeva, Y. Takubo, M. Talby, A. A. Talyshev, K. C. Tam, N. M. Tamir, A. Tanaka, J. Tanaka, R. Tanaka, M. Tanasini, J. Tang, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G. F. Tartarelli, P. Tas, M. Tasevsky, E. Tassi, A. C. Tate, G. Tateno, Y. Tayalati, G. N. Taylor, W. Taylor, H. Teagle, A. S. Tee, R. Teixeira De Lima, P. Teixeira-Dias, J. J. Teoh, K. Terashi, J. Terron, S. Terzo, M. Testa, R. J. Teuscher, A. Thaler, O. Theiner, N. Themistokleous, T. Theveneaux-Pelzer, O. Thielmann, D. W. Thomas, J. P. Thomas, E. A. Thompson, P. D. Thompson, E. Thomson, E. J. Thorpe, Y. Tian, V. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, E. X. L. Ting, P. Tipton, S. Tisserant, S. H. Tlou, A. Tnourji, K. Todome, S. Todorova-Nova, S. Todt, M. Togawa, J. Tojo, S. Tokár, K. Tokushuku, R. Tombs, M. Tomoto, L. Tompkins, K. W. Topolnicki, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, M. Toscani, C. Tosciri, M. Tost, D. R. Tovey, A. Traeet, I. S. Trandafir, T. Trefzger, A. Tricoli, I. M. Trigger, S. Trincaz-Duvoid, D. A. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, M. Tsai, A. Tsiamis, P. V. Tsiareshka, S. Tsigaridas, A. Tsirigotis, V. Tsiskaridze, E. G. Tskhadadze, M. Tsopoulou, Y. Tsujikawa, I. I. Tsukerman, V. Tsulaia, S. Tsuno, O. Tsur, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A. N. Tuna, S. Turchikhin, I. Turk Cakir, R. Turra, T. Turtuvshin, P. M. Tuts, S. Tzamarias, P. Tzanis, E. Tzovara, K. Uchida, F. Ukegawa, P. A. Ulloa Poblete, E. N. Umaka, G. Unal, M. Unal, A. Undrus, G. Unel, J. Urban, P. Urquijo, G. Usai, R. Ushioda, M. Usman, Z. Uysal, L. Vacavant, V. Vacek, B. Vachon, K. O. H. Vadla, T. Vafeiadis, A. Vaitkus, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, A. Vallier, J. A. Valls Ferrer, T. R. Van Daalen, P. Van Gemmeren, M. Van Rijnbach, S. Van Stroud, I. Van Vulpen, M. Vanadia, W. Vandelli, M. Vandenbroucke, E. R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E. W. Varnes, C. Varni, T. Varol, D. Varouchas, L. Varriale, K. E. Varvell, M. E. Vasile, L. Vaslin, G. A. Vasquez, F. Vazeille, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M. J. Veen, I. Veliscek, L. M. Veloce, F. Veloso, S. Veneziano, A. Ventura, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, J. C. Vermeulen, C. Vernieri, P. J. Verschuuren, M. Vessella, M. C. Vetterli, A. Vgenopoulos, N. Viaux Maira, T. Vickey, O. E. Vickey Boeriu, G. H. A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E. M. Villhauer, E. Vilucchi, M. G. Vincter, G. S. Virdee, A. Vishwakarma, C. Vittori, I. Vivarelli, V. Vladimirov, E. Voevodina, F. Vogel, P. Vokac, J. Von Ahnen, E. Von Toerne, B. Vormwald, V. Vorobel, K. Vorobev, M. Vos, J. H. Vossebeld, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, M. Vreeswijk, R. Vuillermet, O. Vujinovic, I. Vukotic, S. Wada, C. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, R. Wakasa, M. Wakida, V. M. Walbrecht, J. Walder, R. Walker, W. Walkowiak, A. M. Wang, A. Z. Wang, C. Wang, H. Wang, J. Wang, R.-J. Wang, R. Wang, S. M. Wang, S. Wang, T. Wang, W. T. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, R. J. Ward, N. Warrack, A. T. Watson, H. Watson, M. F. Watson, G. Watts, B. M. Waugh, A. F. Webb, C. Weber, H. A. Weber, M. S. Weber, S. M. Weber, C. Wei, Y. Wei, A. R. Weidberg, J. Weingarten, M. Weirich, C. Weiser, C. J. Wells, T. Wenaus, B. Wendland, T. Wengler, N. S. Wenke, N. Wermes, M. Wessels, K. Whalen, A. M. Wharton, A. S. White, A. White, M. J. White, D. Whiteson, L. Wickremasinghe, W. Wiedenmann, C. Wiel, M. Wielers, N. Wieseotte, C. Wiglesworth, L. A. M. Wiik-Fuchs, D. J. Wilbern, H. G. Wilkens, D. M. Williams, H. H. Williams, S. Williams, S. Willocq, P. J. Windischhofer, F. Winklmeier, B. T. Winter, J. K. Winter, M. Wittgen, M. Wobisch, R. Wölker, J. Wollrath, M. W. Wolter, H. Wolters, V. W. S. Wong, A. F. Wongel, S. D. Worm, B. K. Wosiek, K. W. Woźniak, K. Wraight, J. Wu, M. Wu, S. L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T. R. Wyatt, B. M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, X. Xiao, M. Xie, X. Xie, S. Xin, J. Xiong, I. Xiotidis, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, W. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, N. Yamaguchi, Y. Yamaguchi, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H. J. Yang, H. T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, Y. C. Yap, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. K. Yeo, M. R. Yexley, P. Yin, K. Yorita, S. Younas, C. J. S. Young, C. Young, M. Yuan, R. Yuan, L. Yue, X. Yue, M. Zaazoua, B. Zabinski, E. Zaid, T. Zakareishvili, N. Zakharchuk, S. Zambito, J. A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, S. V. Zeißner, C. Zeitnitz, J. C. Zeng, D. T. Zenger, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, B. Zhang, D. F. Zhang, G. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, P. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, C. Zhou, H. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, C. Zhu, H. L. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, N. I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T. G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A search for leptoquark pair production decaying into $$te^- \bar{t}e^+$$ t e - t ¯ e + or $$t\mu ^- \bar{t}\mu ^+$$ t μ - t ¯ μ + in final states with multiple leptons is presented. The search is based on a dataset of pp collisions at $$\sqrt{s}=13~\text {TeV} $$ s = 13 TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb $$^{-1}$$ - 1 . Four signal regions, with the requirement of at least three light leptons (electron or muon) and at least two jets out of which at least one jet is identified as coming from a b-hadron, are considered based on the number of leptons of a given flavour. The main background processes are estimated using dedicated control regions in a simultaneous fit with the signal regions to data. No excess above the Standard Model background prediction is observed and 95% confidence level limits on the production cross section times branching ratio are derived as a function of the leptoquark mass. Under the assumption of exclusive decays into $$te^{-}$$ t e - ( $$t\mu ^{-}$$ t μ - ), the corresponding lower limit on the scalar mixed-generation leptoquark mass $$m_{\textrm{LQ}_{\textrm{mix}}^{\textrm{d}}}$$ m LQ mix d is at 1.58 (1.59) TeV and on the vector leptoquark mass $$m_{{\tilde{U}}_1}$$ m U ~ 1 at 1.67 (1.67) TeV in the minimal coupling scenario and at 1.95 (1.95) TeV in the Yang–Mills scenario.

Published
2024
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177. A review: Pancreatic enzymes in the treatment of chronic pancreatic insufficiency in companion animals

Author

Dominika Szkopek, Stefan G. Pierzynowski, Kateryna Pierzynowska, Kamil Zaworski, Agata Kondej, Piotr Wychowański, Paweł Konieczka, Blanka Seklecka, Janine Donaldson, Michał Jank, and Jarosław Woliński

Subjects
animal‐derived enzymes, exocrine pancreatic insufficiency, microbial‐derived enzymes, pancreatic replacement therapy, Veterinary medicine, SF600-1100
Abstract

Abstract The purpose of this review was to analyze the scientific literature on exocrine pancreatic insufficiency (EPI) in dogs and cats and our own research on porcine model to compare animal‐ and microbial‐derived enzymes in the treatment of animals with this disease. Clinical signs of EPI occur when more than 85% of the pancreatic parenchyma is non‐functional. EPI can be a consequence of various diseases. The insufficient activity or deficiency of pancreatic enzymes leads to impaired digestion and absorption, and consequently, to malnutrition. The primary treatment for enzyme insufficiency is pancreatic enzyme replacement therapy (PERT). PERT in animals with EPI is a lifetime therapy. Most commercially available products are of animal origin (processed pancreata obtained from a slaughter house) and contain lipases, alpha‐amylase, and proteases. Enzymes of microbial and plant origin seem to be a promising alternative to animal‐derived enzymes, but to date there are no registered preparations containing all enzymes simultaneously for use in clinical practice to treat EPI. Results from some previous studies have highlighted the “extra‐digestive” functions of pancreatic enzymes, as well as the actions of pancreatic‐like microbial enzymes. For example, trypsin activates protease‐activated receptor and provokes maturation of enterocytes and enterostatin inhibits fat absorption. It has been postulated that intrapancreatic amylase is the main component of the acini‐islet‐acinar axis—the reflex which down regulates insulin release, while gut and blood amylase exhibit anti‐incretin actions “per se.” Additionally, high but still physiological blood amylase activity coincide with physiological glucose homeostasis and a lack of obesity.

Published
2024
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178. No Room for Modesty in Heritage Significance: The Case of Dennesig in Stellenbosch, South Africa

Author

Donaldson, Ronnie

Subjects
authenticity, built heritage resources, modest heritage, heritage conservation areas, heritage significance, Geography. Anthropology. Recreation
Abstract

Significance and authenticity are two key concepts that run through the practice of urban heritage conservation. When combined, they form a powerful tool within a value-based system that ensures the preservation and continued use of historic places. Stellenbosch, being the second oldest town in South Africa, holds great importance as a historic town. However, several historic suburbs have experienced processes of redevelopment, studentification, and gentrification over the past decade, resulting in their deterioration. But what happens when the unique heritage character of a place is considered insignificant by developers, heritage practitioners, architects, and the local authority? This paper focuses on the Dennesig neighborhood in Stellenbosch, where the broader context of modest heritage significance has been neglected and erased from historical records due to poorly conceived planning, urban design, and mismanagement of heritage resources. The argument put forth in this paper is that in order to evaluate a specific case study site, one must consider the complexities of broader heritage and urban planning processes. This understanding is crucial to comprehend the factors that have shaped the current context and the eventual significance attributed to a particular place, setting, or townscape.

Published
2024
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179. SMARCB1 Gene Therapy Using a Novel Tumor-Targeted Nanomedicine Enhances Anti-Cancer Efficacy in a Mouse Model of Atypical Teratoid Rhabdoid Tumors

Author

Kim SS, Moghe M, Rait A, Donaldson K, Harford JB, and Chang EH

Subjects
lipid nanoparticle, nanodelivery, smarcb1, gene therapy, atypical teratoid rhabdoid tumor, Medicine (General), R5-920
Abstract

Sang-Soo Kim,1,2 Manish Moghe,1 Antonina Rait,1 Kathryn Donaldson,1 Joe B Harford,2 Esther H Chang1 1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA; 2SynerGene Therapeutics, Inc, Potomac, MD, USACorrespondence: Esther H Chang, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road N.W., Research Building E420, Washington, DC, 20057, USA, Email change@georgetown.eduPurpose: Atypical teratoid rhabdoid tumor (ATRT) is a deadly, fast-growing form of pediatric brain cancer with poor prognosis. Most ATRTs are associated with inactivation of SMARCB1, a subunit of the chromatin remodeling complex, which is involved in developmental processes. The recent identification of SMARCB1 as a tumor suppressor gene suggests that restoration of SMARCB1 could be an effective therapeutic approach.Methods: We tested SMARCB1 gene therapy in SMARCB1-deficient rhabdoid tumor cells using a novel tumor-targeted nanomedicine (termed scL-SMARCB1) to deliver wild-type SMARCB1. Our nanomedicine is a systemically administered immuno-lipid nanoparticle that can actively cross the blood-brain barrier via transferrin receptor-mediated transcytosis and selectively target tumor cells via transferrin receptor-mediated endocytosis. We studied the antitumor activity of the scL-SMARCB1 nanocomplex either as a single agent or in combination with traditional treatment modalities in preclinical models of SMARCB1-deficient ATRT.Results: Restoration of SMARCB1 expression by the scL-SMARCB1 nanocomplex blocked proliferation, and induced senescence and apoptosis in ATRT cells. Systemic administration of the scL-SMARCB1 nanocomplex demonstrated antitumor efficacy as monotherapy in mice bearing ATRT xenografts, where the expression of exogenous SMARCB1 modulates MYC-target genes. scL-SMARCB1 demonstrated even greater antitumor efficacy when combined with either cisplatin-based chemotherapy or radiation therapy, resulting in significantly improved survival of ATRT-bearing mice.Conclusion: Collectively, our data suggest that restoring SMARCB1 function via the scL-SMARCB1 nanocomplex may lead to therapeutic benefits in ATRT patients when combined with traditional chemoradiation therapies. Keywords: lipid nanoparticle, nanodelivery, SMARCB1, gene therapy, atypical teratoid rhabdoid tumor

Published
2024

182. Educational Improvement Opportunities outside of the Regular School Day Grant Program. Report to the Education Interim Committee

Author

Utah State Board of Education (USBE), Voorhies, Leah, Donaldson, Rebecca, Palmer, Robert, Sheikh, Kamille, and Berry, Emily

Abstract

This report is provided to the Education Interim Committee to report on the Educational Improvement Opportunities Outside of the Regular School Day Grant Program specified in Utah Code 53F-5-210. This program is also called the Program Quality Enhancement (PQE) grant program, as it seeks to improve the quality of existing programs operating outside of the regular school day. The requirement for this report is to review the PQE grant program outcomes, including the quality improvement efforts and the impact on the academic performance of participating students in funded programs during the 2019-20 school year. [For the July 2020 report, see ED622007.]

Published
2021

183. College after Prison: A Review of the Literature on Barriers and Supports to Postsecondary Education for Formerly Incarcerated College Students

Author

John Jay College Institute for Justice and Opportunity, City University of New York (CUNY), Office of Research, Evaluation, and Program Support (REPS), Donaldson, Vernisa M., and Viera, Christopher

Abstract

The white paper synthesizes existing literature around higher education for formerly incarcerated individuals and describes the need for more work in this area. More than 650,000 individuals are released from state and federal prisons and return to the community each year. However, most programming and research have been concentrated on correctional education. As a result, formerly incarcerated individuals are largely not recognized as a student group needing support, programming, and research in the higher education space. [Additional funding for this report from the Mayor's Office of Criminal Justice.]

Published
2021

184. PANDORA project: photo-nuclear reactions below $A=60$

Author

Tamii, A., Pellegri, L., Söderström, P. -A., Allard, D., Goriely, S., Inakura, T., Khan, E., Kido, E., Kimura, M., Litvinova, E., Nagataki, S., von Neumann-Cosel, P., Pietralla, N., Shimizu, N., Tsoneva, N., Utsuno, Y., Adachi, S., Adsley, P., Bahini, A., Balabanski, D., Baret, B., Bekker, J. A. C., Binda, S. D., Boicu, E., Bracco, A., Brandherm, I., Brezeanu, M., Brummer, J. W., Camera, F., Crespi, F. C. L., Dalal, R., Donaldson, L. M., Fujikawa, Y., Furuno, T., Haoning, H., Honda, Y., Gavrilescu, A., Inoue, A., Isaak, J., Jivan, H., Jones, P. M., Jongile, S., Just, O., Kawabata, T., Khumalo, T., Kiener, J., Kleemann, J., Kobayashi, N., Koshio, Y., Kuşoğlu, A., Li, K. C. W., Malatji, K. L., Molaeng, R. E., Motoki, H., Murata, M., Netshiya, A. A., Neveling, R., Niina, R., Okamoto, S., Ota, S., Papst, O., Parizot, E., Petruse, T., Reen, M. S., Ring, P., Sakanashi, K., Sideras-Haddad, E., Siem, S., Spall, M., Suda, T., Sudo, T., Taniguchi, Y., Tatischeff, V., Utsunomiya, H., Wang, H., Werner, V., Wibowo, H., Wiedeking, M., Wieland, O., Xu, Y., and Yang, Z. H.

Subjects
Nuclear Experiment, Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

Photo-nuclear reactions of light nuclei below a mass of $A=60$ are studied experimentally and theoretically by the PANDORA (Photo-Absorption of Nuclei and Decay Observation for Reactions in Astrophysics) project. Two experimental methods, virtual-photon excitation by proton scattering and real-photo absorption by a high-brilliance gamma-ray beam produced by laser Compton scattering, will be applied to measure the photo-absorption cross sections and the decay branching ratio of each decay channel as a function of the photon energy. Several nuclear models, e.g. anti-symmetrized molecular dynamics, mean-field type models, a large-scale shell model, and ab initio models, will be employed to predict the photo-nuclear reactions. The uncertainty in the model predictions will be evaluated from the discrepancies between the model predictions and the experimental data. The data and the predictions will be implemented in a general reaction calculation code TALYS . The results will be applied to the simulation of the photo-disintegration process of ultra-high-energy cosmic rays in inter-galactic propagation.

Published
2022

185. Closed 3-forms in five dimensions and embedding problems

Author

Donaldson, Simon and Lehmann, Fabian

Subjects
Mathematics - Differential Geometry, 53C26 (Primary), 32V30 (Secondary)
Abstract

We consider the question if a five dimensional manifold can be embedded into a Calabi-Yau manifold of complex dimension three such that the real part of the holomorphic volume form induces a given closed 3-form on the 5-manifold. We define an open set of 3-forms in dimension five which we call strongly pseudoconvex, and show that for closed strongly pseudoconvex 3-forms the perturbative version of this embedding problem can be solved if a finite dimensional vector space of obstructions vanishes.

Published
2022

189. Correlates of prior HIV testing and schistosomiasis treatment: Baseline survey findings from the creating demand for fishermens schistosomiasis HIV services (FISH) cluster-randomized trial in Mangochi, Malawi.

Author

Kangogo, Geoffrey, Conserve, Donaldson, Kayuni, Sekeleghe, Kumwenda, Moses, Dovel, Kathryn, Chirombo, James, MacPherson, Peter, Corbett, Elizabeth, Butterworth, Anthony, and Choko, Augustine

Subjects
Humans, Praziquantel, Malawi, Schistosomiasis, HIV Infections, HIV Testing, Surveys and Questionnaires
Abstract

BACKGROUND: Fishing exposes fishermen to schistosomiasis-infested fresh water and concurrently through precarious livelihoods to risky sexual behaviour, rendering these two infections occupational hazards for fishermen. This study aimed to characterize the knowledge of the two conditions to obtain necessary data for a subsequent cluster randomized trial designed to investigate demand creation strategies for joint HIV-schistosomiasis service provision in fishing villages on the shores of southern Lake Malawi. METHODS: Enumeration of all resident fishermen in 45 clusters (fishing communities) was carried out between November 2019 and February 2020. In a baseline survey, fishermen reported their knowledge, attitudes and practices in the uptake of HIV and schistosomiasis services. Knowledge of HIV status and previous receipt of praziquantel were modelled using random effects binomial regression, accounting for clustering. Prevalence of willingness to attend a beach clinic was computed. RESULTS: A total of 6,297 fishermen were surveyed from the 45 clusters with harmonic mean number of fishermen per cluster of 112 (95% CI: 97; 134). The mean age was 31.7y (SD: 11.9) and nearly 40% (2,474/6,297) could not read or write. Overall, 1,334/6,293 (21.2%) had never tested for HIV, with 64.4% (3,191/4,956) having tested in the last 12 months, and 5.9% (373/6290) taking antiretroviral therapy (ART). In adjusted analyses, being able to read and write (adjusted risk ratio [aRR: 1.91, 95% CI: 1.59-2.29, p

Published
2023

190. Flavors increase adolescents’ willingness to try nicotine and cannabis vape products

Author

Chaffee, Benjamin W, Couch, Elizabeth T, Wilkinson, Monica L, Donaldson, Candice D, Cheng, Nancy F, Ameli, Niloufar, Zhang, Xueying, and Gansky, Stuart A

Subjects
Paediatrics, Biomedical and Clinical Sciences, Drug Abuse (NIDA only), Pediatric, Cannabinoid Research, Substance Misuse, Electronic Nicotine Delivery Systems, Tobacco, Good Health and Well Being, Humans, Adolescent, Child, Nicotine, Vaping, Cannabis, Flavoring Agents, Tobacco Products, Hallucinogens, Tobacco control, Electronic cigarettes, Adolescent health, Survey epidemiology, Medical and Health Sciences, Psychology and Cognitive Sciences, Substance Abuse, Biochemistry and cell biology, Pharmacology and pharmaceutical sciences, Epidemiology
Abstract

BackgroundCertain product characteristics, such as flavor, may increase adolescents' willingness to try vaped nicotine and cannabis (marijuana) products.MethodsA discrete choice experiment embedded within the 2021-2022 California Teens Nicotine and Tobacco Project Online Survey was administered to a non-probability sample of N = 2342 adolescents ages 12-17. Participants were sequentially presented four randomly-generated pairs of hypothetical vape products that varied in device type (disposable, refillable), content (nicotine, marijuana, "just vapor"), and flavor (seven options) and asked which of these (or neither) they would be more willing to try if a best friend offered. Conditional logistic regression quantified associations between product characteristics and participants' selections, including interactions by past 30-day use of e-cigarettes, marijuana, or both.ResultsCandy/dessert, fruit, and fruit-ice combination flavors were all associated with greater willingness to try a vape product (versus tobacco flavor) among participants not using e-cigarettes or marijuana, those using only e-cigarettes, and those co-using e-cigarettes and marijuana. Among participants only using marijuana, the most preferred flavors were no flavor, candy/dessert, and icy/frost/menthol. Among participants not using e-cigarettes or marijuana, model-predicted willingness to try a displayed vape product was greater when products were sweet or fruit flavored than tobacco or unflavored, regardless of whether displayed options contained nicotine (fruit/sweet: 21 %, tobacco/unflavored: 4 %), marijuana (fruit/sweet: 18 %, tobacco/unflavored: 6 %), or "just vapor" (fruit/sweet: 29 %, tobacco/unflavored: 16 %).ConclusionsIn this online non-probability sample, flavors in nicotine and cannabis vape products increased adolescents' willingness to try them. Comprehensive bans on flavored vapes would likely reduce adolescent use.

Published
2023

191. Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials.

Author

Mayer-Hamblett, Nicole, Ratjen, Felix, Russell, Renee, Donaldson, Scott, Riekert, Kristin, Sawicki, Gregory, Odem-Davis, Katherine, Young, Julia, Rosenbluth, Daniel, Taylor-Cousar, Jennifer, Goss, Christopher, Retsch-Bogart, George, Clancy, John, Genatossio, Alan, OSullivan, Brian, Berlinski, Ariel, Millard, Susan, Omlor, Gregory, Wyatt, Colby, Moffett, Kathryn, Nichols, David, and Gifford, Alex

Subjects
Humans, Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator, Deoxyribonuclease I, Lung, Saline Solution, Hypertonic
Abstract

BACKGROUND: Reducing treatment burden is a priority for people with cystic fibrosis, whose health has benefited from using new modulators that substantially increase CFTR protein function. The SIMPLIFY study aimed to assess the effects of discontinuing nebulised hypertonic saline or dornase alfa in individuals using the CFTR modulator elexacaftor plus tezacaftor plus ivacaftor (ETI). METHODS: The SIMPLIFY study included two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials at 80 participating clinics across the USA in the Cystic Fibrosis Therapeutics Development Network. We included individuals with cystic fibrosis aged 12-17 years with percent predicted FEV1 (ppFEV1) of 70% or more, or those aged 18 years or older with ppFEV1 of 60% or more, if they had been taking ETI and either (or both) mucoactive therapies (≥3% hypertonic saline or dornase alfa) for at least 90 days before screening. Participants on both hypertonic saline and dornase alfa were randomly assigned to one of the two trials, and those on a single therapy were assigned to the applicable trial. All participants were then randomly assigned 1:1 to continue or discontinue therapy for 6 weeks using permuted blocks of varying size, stratified by baseline ppFEV1 (week 0; ≥90% or

Published
2023

192. Enhancing Care Partnerships Using a Rheumatology Dashboard: Bringing Together What Matters Most to Both Patients and Clinicians

Author

Van Citters, Aricca D, Taxter, Alysha J, Mathew, Stephanie D, Lawson, Erica, Eseddi, Joad, Del Gaizo, Vincent, Ahmad, Jabeen, Bajaj, Puneet, Courtnay, Stacy, Davila, Lesley, Donaldson, Brittany, Kimura, Yukiko, Lee, Tzielan, Mecchella, John N, Nelson, Eugene C, Pompa, Scott, Tabussi, Doreen, and Johnson, Lisa C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Arthritis, Pediatric, Behavioral and Social Science, Health Services, Autoimmune Disease, Rheumatoid Arthritis, Inflammatory and immune system, Good Health and Well Being, Clinical sciences
Abstract

ObjectiveDashboards can support person-centered care by helping people partner with their clinicians to coproduce care based on preferences, shared decision-making, and evidence-based treatments. We engaged caregivers of children with juvenile idiopathic arthritis (JIA), adults with rheumatoid arthritis (RA), and clinicians in a pilot study to assess their experiences and the utility and impact of an electronic previsit questionnaire and point-of-care dashboard to support coproduction of rheumatology care.MethodsWe employed a mixed-methods design to assess users' perceptions of a customized electronic health record rheumatology module at four pediatric rheumatology practices and two adult rheumatology practices. We surveyed a convenience sample of caregivers of children with JIA (n = 113), adults with RA (n = 116), and clinicians (n = 12). We conducted semistructured interviews with 13 caregivers and patients and six care teams. Experiences were evaluated using descriptive statistics and thematic analyses.ResultsCaregivers of children with JIA and adults with RA reported the dashboards were useful during discussions (88%) and helped them talk about what mattered most (82%), make health care decisions (83%), and create a treatment plan (77%). Clinicians provided similar feedback. Two-thirds (67%) of caregivers and adults and 55% of clinicians would recommend the dashboard to peers. System usability scores (77.1 ± 15.6) were above average. Dashboards helped users make sense of health information, communicate more effectively, and make decisions. Improvements to the dashboards and workflows could enhance patient self-management and clinician efficiency.ConclusionVisual point-of-care dashboards can support caregivers, patients, and clinicians to coproduce rheumatology care. Findings demonstrate a need to spread and scale for broader benefit and impact.

Published
2023

193. Feasibility of the Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) System for Anesthesia Avoidance in Pediatric Patients: A Multicenter Trial.

Author

Gutkin, Paulina M, Skinner, Lawrie, Jiang, Alice, Donaldson, Sarah S, Loo, Billy W, Oh, Justin, Wang, Yi Peng, von Eyben, Rie, Snyder, John, Bredfeldt, Jeremy S, Breneman, John C, Constine, Louis S, Faught, Austin M, Haas-Kogan, Daphne, Holmes, Jordan A, Krasin, Matthew, Larkin, Charlene, Marcus, Karen J, Maxim, Peter G, McClelland, Shearwood, Murphy, Blair, Palmer, Joshua D, Perkins, Stephanie M, Shen, Colette J, Terezakis, Stephanie, Bush, Karl, and Hiniker, Susan M

Subjects
Pediatric, Clinical Research, Clinical Trials and Supportive Activities, Management of diseases and conditions, 7.1 Individual care needs, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeThe Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) system was the first published radiation therapy (RT)-compatible system to reduce the need for pediatric anesthesia through video-based distraction. We evaluated the feasibility of AVATAR implementation and effects on anesthesia use, quality of life, and anxiety in a multicenter pediatric trial.Methods and materialsPediatric patients 3 to 10 years of age preparing to undergo RT at 10 institutions were prospectively enrolled. Children able to undergo at least 1 fraction of RT using AVATAR without anesthesia were considered successful (S). Patients requiring anesthesia for their entire treatment course were nonsuccessful (NS). The PedsQL3.0 Cancer Module (PedsQL) survey assessed quality of life and was administered to the patient and guardian at RT simulation, midway through RT, and at final treatment. The modified Yale Preoperative Anxiety Scale (mYPAS) assessed anxiety and was performed at the same 3 time points. Success was evaluated using the χ2 test. PedsQL and mYPAS scores were assessed using mixed effects models with time points evaluated as fixed effects and a random intercept on the subject.ResultsEighty-one children were included; median age was 7 years. AVATAR was successful at all 10 institutions and with photon and proton RT. There were 63 (78%) S patients; anesthesia was avoided for a median of 20 fractions per patient. Success differed by age (P = .04) and private versus public insurance (P < .001). Both patient (P = .008) and parent (P = .006) PedsQL scores significantly improved over the course of RT for patients aged 5 to 7. Anxiety in the treatment room decreased for both S and NS patients over RT course (P < .001), by age (P < .001), and by S versus NS patients (P < .001).ConclusionsIn this 10-center prospective trial, anesthesia avoidance with AVATAR was 78% in children aged 3 to 10 years, higher than among age-matched historical controls (49%; P < .001). AVATAR implementation is feasible across multiple institutions and should be further studied and made available to patients who may benefit from video-based distraction.

Published
2023

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