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Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Erzincan University Journal of Science & Technology is the property of Erzincan Binali Yildirim Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Adipoz doku; İnterlökin-6, Tümör Nekröz Faktör-α, C-Reaktif Protein gibi inflamatuvar belirteçler ve adiponektin gibi adipokinleri salgılayan en önemli endokrin organlardan biridir. Tüm bu inflamatuvar faktörler inflamasyon, inflamatuvar yanıt ve Tip 2 diyabet ile ilişkilidir. Modern toplumlarda majör dejeneratif hastalıkların oluşumunda kronik inflamasyonun artan rolü, araştırmacıları beslenme ve diyet örüntüsünün inflamatuvar belirteçler üzerindeki etkisini araştırmaya yönlendirmiştir. Bu derleme yazıda diyetsel etmenlerin Tip 2 diyabet ve inflamasyon üzerindeki etkisi tartışılmıştır.

Amaç: Bu çalışmanın amacı, streptozotosin ile diyabet oluşturulmuş akut yüzme egzersizi yaptırılan sıçanlarda çinko uygulamasının kas dokusundaki lipid peroksidasyonu ve antioksidan kapasite üzerindeki etkisinin araştırılmasıdır.Gereç ve Yöntem: Spraque-Dawley cinsi 80 adet erişkin erkek ratlar kullanılan çalışmada. deney hayvanları eşit sayıda 8 gruba ayrıldı: Grup 1, genel kontrol. Grup 2, çinko uygulanan kontrol. Grup 3, çinko uygulanan diyabetli kontrol. Grup 4, yüzme kontrol. Grup 5, çinko uygulanan yüzme. Grup 6, çinko uygulanan diyabetli yüzme. Grup 7, diyabetli yüzme. Grup 8, diyabet grubu. Diyabet oluşturmak için hayvanlara 40 mg/kg dozunda intraperitoneal ip streptozotosin STZ enjekte edildi. Enjeksiyonlar 24 saat sonra aynı dozda tekrarlandı. Son enjeksiyonlardan 6 gün sonra kan glukozu 300 mg/dl ve üzerinde olan hayvanlar diyabetik olarak kabul edildi. Hayvanlara 4 hafta boyunca 6 mg/kg/gün ip çinko sülfat verildi. Dört hafta süren çalışmanın bitiminde deney hayvanlarından dekapitasyonla alınan kas doku örneklerinde MDA nmol/gram/ protein ve GSH mg/dl/gram protein düzeyleri tayin edildi. Bulgular: Kas dokusundaki en yüksek MDA değerleri grup 4 ve 7’de elde edildi. Grup 5 ve 6’nın kas MDA seviyeleri grup 4 ve 7’den düşük, diğer grupların tamamından yüksekti. Grup 5 ve 6 en yüksek kas GSH değerlerine sahipti. Grup 4’ün aynı parametresi grup 5 ve 6’dan düşük diğer grupların tamamından daha yüksekti. Kas dokusundaki en düşük GSH düzeyleri Grup 7 ve 8’de elde edildi.Sonuç: Çalışmanın sonuçları diyabetik sıçanlarda zorlu yüzme egzersizinin yol açtığı kas dokusundaki lipit peroksidasyonu üzerinde intraperitoneal çinko sülfat uygulamasının koruyucu rolü olduğunu göstermektedir

Amaç: Son dönem çalışmaları C peptitin diyabetik nefropatide yararlı etkileri olduğunu öne sürmektedir. Bu çalışmada tip 2 diyabetes mellitus (T2DM) hastalarında gözlenen mikroalbuminüri ile serum C peptit düzeylerinin ilişkili olup olmadığını analiz etmeyi amaçladık.Gereç ve Yöntem: Bu amaçla 184 tip 2 diyabet hastası ve 46 sağlıklı kontrol çalışmaya alındı. Hastaların klinik özellikleri ve rutin biyokimyasal tetkiklerine ek olarak serum C peptit seviyeleri kaydedildi. Serum C peptit normal aralığı 1.1-4.4 olarak kabul edildi. Hastalardan 24 saatlik idrar toplanarak araştırıldı ve 30-300 mg aralığı mikroalbuminuri olarak kaydedildi. Değişkenler arasındaki ilişkiyi ortaya koymak amacıyla Pearson korelasyon analizi kullanıldı.Bulgular: Tip 2 diyabet hastaları sağlıklı control grubu ile karşılaştırıldığında C peptit düzeyleri arasında anlamlı farklılık saptanmadı. Pearson korelasyon analizinde C peptit düzeyleri, insulin ve mikroalbuminuri arasında pozitif korelasyon olduğu görüldü. Bununla birlikte C –peptit ve diğer değişkenler arasında anlamlı bir ilişki bulunmadı.Sonuç: Bu çalışmada serum C peptit düzeyleri ile mikroalbuminüri varlığının ilişkili olduğunu gösterdik. Bulgular C peptitin T2DM hastalarında renal komplikasyonları ile ilişkili olduğunu ortaya koymaktadır

Objective: Diabetes Mellitus Type 2 (DM2) is characterized by varying degrees of insulin resistance, impaired insulin secretion, and increased glucose production. Some people with DM2 have more complications such as nephropathy, retinopathy, and neuropathy. The earliest stage of renal impairment occurs with prolonged microalbuminuria. This study aimed to determine the incidence of the most common microvascular complications in DM2 patients. Methods: We retrospectively evaluated the data of 126 patients who had undergone treatment in 2014. It includes anamnesis, laboratory, and physical examination data from the patient histories. All patients with early stage DM2 were separated into two groups based on the presence of albuminuria: Group I - macroalbuminuria and Group II - microalbuminuria (<300 mg). Analysis and statistical processing of the collected data were performed to evaluate microvascular complications and determine the incidence of albuminuria in the studied population. Results: The prevalence of macroalbuminuria was 60.3% (76 patients). In both groups, as in the total sample, the frequency of women was higher (57.9%). The prevalence of macroalbuminuria was strongly influenced by age (=65 years) of the patients (72.4%, average age = 69.8±11.1 years). Microalbuminuria has been proven to be an extremely significant marker for development of microvascular complications in DM2 (retinopathy 39.5%, neuropathy 52.6%, and nephropathy 54%). Conclusion: Early diagnosis of microvascular complications and an adequate therapeutic approach is needed to prevent disability. Therefore, it is important to introduce the screening for the presence of microalbuminuria in practice, which will identify patients at increased risk of developing microvascular complications. [ABSTRACT FROM AUTHOR]

Objective: Rising prevalence of non-alcoholic fatty liver disease (NAFLD), its high incidence in diabetic patients, and global diabetes prevalence, underline the need to identify comorbidities in these patients impacting their quality of life and mortality. NAFL-Dis associated with increased risk, prevalence, and complications of cardiovascular diseases in diabetic and non-diabetics alike. The study aimed to establish a relationship between non-invasively assessed cardiovascular morbidity and NAFLD fibrosis score (NFS) in type 2 diabetes mellitus with NAFLD. Material and Methods: After ethical approval, the study was conducted (n=100) on patients <60 years of age, having type 2 diabetes mellitus, and no existing cardiovascular disease. All patients underwent anthropological and routine investigations, two-dimen-sion (2D) echocardiography, and ultrasonographic confirmation of fatty liver disease. NAFLD was ascertained based on patient history and investigations. Findings of cardiovascular evaluation on 2D-echocardiography were assessed with reference to the NFS. Results: Median age of participants was 53.5 years. Body mass index (p<0.001), right carotid intima-media thickness (p=0.0124), and left ventricular dysfunction (p=0.0024) showed a significant association with NAFLD. The presence of both left ventricular diastolic dysfunction and significant variation of carotid intima-media thickness among mild, moderate, and severe NFS groups (p=0.0049) was observed. Patients with moderate-severe NFS had 6.38 times more risk of developing cardiovascular morbidities. Conclusion: In patients with type 2 diabetes and NAFLD, the NFS helps to identify those at high risk of cardiovascular disease, and patients needing further investi-gation. It provides clues on how non-invasive cardiovascular markers can be used in detecting cardiovascular morbidities. [ABSTRACT FROM AUTHOR]

Objectives: Obesity has become an important public health problem because of its increasing prevalence and relation with many diseases and mortality. Studies have shown its association with oxidative stress. In this study, the effect of obesity on total amount of thiol and some glutathione S-transferase (GST) isozymes were investigated which could serve as an important criteria in dose adjustment of some certain drugs in obese. Methods: The gastric tissues removed by gastrectomy operation from 29 morbid obese female patients were analysed for thiol levels and activities of total GST, GSTT1-1 and GSTM1-1. Patients were grouped according to age, presence of hypertension and/or diabetes, and family history. Results: The average total thiol was 131.22 (±7.74) nmol/mg protein with no significant differences in between the groups. GSTT1 specific activities were about 20% higher in four groups: with ages over 35 years old, with hypertension, without diabetes and finally without family history, with respect to other groups. The differences between total GST and GSTM1 activity levels of experimental groups were not significant. Conclusions: This is the first study to compare activities of GST isozymes and total thiol content in the stomach tissues of obese female patients accompanying some common metabolic disorders, age and family history. [ABSTRACT FROM AUTHOR]

Objectives: Since sexual psychophysiology can be affected by many variables, studies on the frequency of sexual dysfunction (SD) in diabetic patients produce quite different results. There is a need for regional studies conducted with methods to consolidate these different results. The purpose of this meta-analysis study is to reveal the combined prevalence of SD in women with diabetes and to examine the effects of possible diabetic and demographic variables on the prevalence of SD. Materials and Methods: For this meta-analysis study, the literature was searched with the "Google Scholar" database. Observational studies investigating SD in women with diabetes in Turkey between January 2000 and August 2020 were included in the meta-analysis. Results: The prevalence of SD in diabetic women was 58.95% according to the random-effects model. Arousal, desire, pain, satisfaction, lubrication and orgasm disorders were found as 57.75%, 56.63%, 45.63%, 40.22%, 38.61% and 49.25%, respectively. According to meta-regression results, the effects of HbA1c, diabetes duration, age, and body mass index on SD were not determined. Conclusion: SD is higher than the general population of women with diabetes in Turkey. Considering the possible problems encountered in diagnosis, these patients should be questioned for SD and the necessary patients should be directed to specialized clinics. [ABSTRACT FROM AUTHOR]

Objective: Elevated depressive symptoms and disorders affect one in five patients with diabetes. Current guidelines recommend screening depression in the diabetic population. Turkey has the highest (13.7%) prevalence of diabetes in Europe. However, there are limited data about the prevalence of depressive disorders among diabetic patients in Turkey. We aim to investigate the prevalence of a comorbid depressive disorder in Type 2 diabetic patients who were referred to the Endocrinology outpatient unit of a tertiary hospital. Material and Methods: All the Type 2 diabetic patients admitted to our endocrinology department were consecutively included in the study. Their sociodemographics, concomitant diseases and medications, macro and microvascular complications, lifestyle and personal habits, and treatment regimens were obtained by a specifically designed questionnaire. Laboratory data were obtained from the hospital records. The Patient Health Questionnaire-9 (PHQ-9), a depression screening tool, was used as a screening method for depression. Patients with a score of 10 or above determined high risk for depressive disorder according to PHQ-9. The scores were re-evaluated by a psychiatrist to minimize the false negative and positive results. Result: A total of 460 patients with Type 2 diabetic were enrolled in this crosssectional study. 18.9% (n=87) of the participants were found to have depressive disorders according to the psychiatric evaluation done after the PHQ-9 questionnaire. Patients with depressive disorders were predominantly female (69.0% vs. 55.5%; p=0.022), younger (57.2±10.5 vs. 60.0±9.5; p=0.014), had higher HbA1c (8.51±2.51 vs. 7.98±2.05; p=0.042), total cholesterol (205.6±44.2 vs. 194.2±46.0; p=0.045), LDL-cholesterol (123.1±37.8 vs. 113.1±35.4; p=0.026) and non-HDL-cholesterol (158.5±41.61 vs. 146.6±42.7; p=0.024). These patients had frequent neuropathy (37.3% vs. 19.0%, p=0.001), they were less likely to perform exercise (31.8% vs. 53.1%; p<0.001) while smoke in excess (31.4% vs. 14.3%; p<0.001). The analysis showed that female gender (OR=4.4; 95% CI=1.6-12.8; p=0.005) and smoking (OR=7.6; 95% CI=2.8-20.5, p<0.001) are independent determinants of a depressive disorder. Conclusion: Approximately one-fifth of diabetic patients had a depressive disorder, and their metabolic parameters were worse than those without a depressive disorder. Therefore, to assess a diabetic patient from all aspects, screening for depressive disorder should be made an indispensable part of the evaluation process. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Surgery & Medicine (JOSAM) is the property of Journal of Surgery & Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Firat Universitesi Saglik Bilimleri Veteriner Dergisi is the property of Firat Universitesiu, Saglik Bilimleri Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Diabetes mellitus (DM) is a metabolic disease that occurs with complete or partial absence of insulin. Sepsis is the complex inflammatory response of the host against an infection or trauma. The clinical course of sepsis is more severe in patients with diabetes than in normal individuals. Pomegranate peel extract has high antioxidant capacity, anti-cancer, antimicrobial, anti-inflammatory and anti-diabetic activity. The aim of this study is to investigate the anti-oxidant and anti-cytokine properties of pomegranate peel extract in sepsis induced lung damage under diabetic conditions. Method: The pomegranate peel was decorticated and dried. Extraction processes were applied. Ethanol was used as extraction solvent. After extraction, solvent was evaporated and the pomegranate peel extract was obtained. In our study, 30 rats were used. Our Groups are; Group 1: Control, Group 2: Sepsis, Group 3: DM + S (Diabetes + Sepsis), Group 4: DM + S + NKE250 (Diabetes + Sepsis + Pomegranate peel extract 250 mg / kg), Group 5: DM + S + NKE500 (Diabetes + Sepsis + Pomegranate peel extract 500 mg / kg). Diabetes was induced with a single dose of 55-mg/kg streptozocin. After 72 hours, fasting blood glucose levels were measured. Rats with fasting blood glucose higher than 250 mg/dl were considered as diabetes. The pomegranate peel extract was administered orally at doses of 250 mg/kg and 500 mg/kg for 10 days after diabetes detection. Lipopolysaccharide was intraperitoneal administered at the dose of 5 mg/kg at the end of the 10th day. Lung tissue was dissected out after 12 hours. SOD activity, GSH and MDA levels and TNF-α and IL-1β mRNA expression levels were measured in lung tissue. Results: It was seen that SOD activity and GSH levels decreased in the sepsis group when compared with the control group. It was found that SOD activity and GSH level in diabetes + sepsis group decreased when compared to both control and sepsis groups. TNF-α and IL-1β mRNA expression and MDA level increased in the sepsis group when compared to the Control group. It was found that TNF-α and IL-1β mRNA expression and MDA level in diabetes + sepsis group increased when compared to both control and sepsis groups. When compared with the diabetes + sepsis group, it was observed that the SOD activity, GSH level increased and TNF-α, IL-1β mRNA expression and MDA levels decreased depending on the dose in groups that administered pomegranate peel. Conclusion: Pomegranate peel extract shows anti-oxidant and anti-inflammatory activity by regulating the balance between antioxidants and oxidants and reducing the amount of cytokines. For these reasons, the use of pomegranate peel extract will yield beneficial results on lung damage in case that diabetes and sepsis diseases coexist, which the antioxidant/oxidant balance is disturbed and cytokine storm is intense. [ABSTRACT FROM AUTHOR]

Copyright of Harran University Journal of the Faculty of Veterinary Medicine / Harran Üniversitesi Veteriner Fakültesi Dergisi is the property of Harran University, Faculty of Veterinary Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The aim of this study is to research the neurocognitive, neuroprotective and analgesic effects of the memantine in diabetic rats after anaesthesia. Postoperative cognitive dysfunction is a frequent complication after anaesthesia. Although the reason of this hasn’t been explained completely, there are numerous risk factors such as the increase of cognitive dysfunction during postoperative period. Being in older age, coexisting diseases, etc. are among these risk factors. Propofol, one of the anaesthetic agents, is an agent causing the postoperative cognitive dysfunction. Memantine has beneficial effects on memory deficits and learning process. Additionally, it is an agent which also has neuroprotective effects, and is used for the treatment of chronic pain syndromes. In this study, we aim to determine its effects on recovery, cognitive functions and pain of memantine after propofol anaesthesia. Materials and Methods: Thirty Wistar rats were divided into 5 groups randomly. 0,9 % NaCl (1ml i.p.) were given to Group C on 31st day after normal nutrition period during 30 days. 0,9 % NaCl (1ml i.p.) was given to Group DC on 31st day after normal nutrition period during 30 days. 0,9 % NaCl (1ml i.p.) was given to Group DM on 31st day after oral memantine treatment (20 mg/kg/day) during 30 days. Propofol (150 mg/kg i.p.) was given to Group DP on 31th day after normal nutrition period during 30 days. Propofol (150 mg/kg i.p.) was given to Group DPM on 31th day after oral memantine treatment (20 mg/kg/day) during 30 days. Recovery, cognitive function and the pain level of the rats are evaluated with “tail pinch”, “Radial Arm Maze” and “hot-plate” respectively. Results: Recovery durations of the rats in Group DMP were shorter than rats in Group DP (p< 0,0001). Hot-plate values were significantly longer than control values in all groups, except for Group C, when compared in-group (p<0,05). Conclusion: In conclusion, this study showed that memantine has beneficial effects on recovery, cognitive functions and pain after propofol anaesthesia in diabetic rats. [ABSTRACT FROM AUTHOR]

Chemotherapy treatment and autologous and allogeneic cell transplantations are often complicated by the onset of metabolic and endocrine disorders. Autoimmune disorders, metabolic diseases, and hormonal dysfunctions are some of the endocrine complications observed during or after treatment with immunotherapy (mostly novel agents) and/or chemotherapy conditioning for transplantation. Although successful treatment of the underlying hematological condition often improves the dysfunction, endocrinopathies can have an impact on prognosis and are associated with poor survival; therefore, it is important to detect and treat them as early as possible. An increased incidence of cardiovascular diseases and metabolic syndrome has been observed after transplantation mostly in longterm survivors. In addition, chemotherapy and radiation along with the prolonged use of corticosteroids can contribute to the onset of thyroid and gonadal dysfunctions. The aim of this article is to describe metabolic dysfunctions occurring in patients who underwent allogeneic cell transplantation. [ABSTRACT FROM AUTHOR]

Copyright of Agri: Journal of the Turkish Society of Algology / Türk Algoloji (Ağrı) Derneği'nin Yayın Organıdır is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: In this study, it was aimed to evaluate the effects of diabetes and anthropometric measurements on disease severity in patients with Obstructive Sleep Apnea syndrome (OSAS). Materials and Methods: Seventy-three volunteers, 20 female and 53 male, who were 30 years old and over, diagnosed with OSAS, who applied to Marmara University Institute of Neurological Sciences Sleep Unit and İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Neurology, Sleep Disorders Center, participated in the study. The demographic characteristics of the patients were determined by the STOP-BANG test, face-to-face questionnaire, and anthropometric measurements were made. Results: In the study, it was observed that the OSAS risk determined by STOP-BANG test in men and women was correlated with the measurements of weight, waist circumference, chest circumference and neck circumference, except body mass index and hip circumference. Diabetes was detected in 17 (23.2%) of OSAS patients, but no significant relationship was found between OSAS severity and anthropometric measurements. Conclusion: In our study, it was determined that there is a significant relationship between anthropometric measurements and OSAS severity, and this is especially evident in male gender. A higher rate of diabetes was found in OSAS patients compared to the general population. However, it was observed that anthropometric measurements did not play a role among the mechanisms underlying the relationship between OSAS and diabetes. [ABSTRACT FROM AUTHOR]

Objective: In cardiac surgery, low serum albumin level is an important risk factor that increases mortality and morbidity in the postoperative period. Diabetes mellitus may affect this clinical condition by causing albumin loss with proetinuria. In this study, the effects of preoperative albumin values and the presence of diabetes mellitus (DM) on postoperative renal failure were investigated. Method: Patients who underwent coronary artery bypass grafting between 01.01.2015-31.12.2019 in our clinic were retrospectively analyzed. Patients who received dialysis treatment in the preoperative period, whose ejection fraction was below 50%, and who underwent emergency surgery were excluded from the study. The patients were divided into 3 groups according to the serum albumin levels before surgery. Patients with serum albumin level ≥3.5 mgr/dL Group 1; those between 2.5-3.5 mg/dL Group 2; patients with ≤ 2.5 were named as Group 3. Later, these 3 groups were divided into 2 subgroups according to the presence of DM. Results: 308 patients who underwent coronary artery bypass surgery were included in the study. The demographic characteristics, peroperative data and operative data of the patients were similar. The need for renal replacement therapy was higher in Group 2 and Group 3 than in Group 1 in the postoperative period. Conclusion: Preoperative low serum albumin is a risk factor for the development of acute renal failure in the postoperative period, and the presence of DM adversely affects this condition. Close follow-up of these patients positively contributes to reducing mortality and morbidity. [ABSTRACT FROM AUTHOR]

Objective: A decreased antiatherogenic function of endothelium causes endothelial dysfunction characterized by decreased nitric oxide (NO) levels. NO amounts can be regulated by the inhibition of eNOS enzyme activity via caveolin-1 (Cav-1). We aimed to determine the effect of CAV1 rs3807990 on metabolic and lipid biomarker levels in diabetic and non-diabetic coronary heart disease (CHD) and to determine the possible contribution to diabetic dyslipidemia. Material and Method: CAV1 rs3807990 was assessed by the Polymerase Chain Reaction-Restriction Fragment length Polymorphism in 32 diabetics and 41 non-diabetic CHD patients. Results: T allele is associated with high total-cholesterol levels in non-diabetic CHD patients (p=0.021). T-allele carriers in diabetic CHD patients had high LDL-C (p=0.037) and glucose levels (p=0.076) compared to the CC-genotype. In addition, the T allele in diabetic-CHD patients was associated with an increase in serum triglyceride levels. Conclusion: In diabetic-CHDs, the association of CAV1 rs3807990-T allele with high glucose and triglycerides was consistent with the relationship between glucose and triglyceride metabolism. T-allele was also found associated with hypercholesterolemia in both groups. CAV1 rs3807990-T allele may be one of the genetic risk factors for hypercholesterolemia and may cause an increase in glucose. It may also contribute to triglyceride elevation and, consequentdeğerlendily, contribute to dyslipidemic phenotype, especially in diabetic- CHD patients. [ABSTRACT FROM AUTHOR]

Objective: Recently, machine learning methods have been widely used in disease diognosis. However, due to the large volume, multidimensional and complexity of the information, an unbalanced data problem arises. In this study, it is aimed to eliminate problem of imbalance by using re-sampling methods in an unbalanced data set related to diabetes patients, to classify diagnosis of diabetes with ensemble learning algorithms and to compare correct classification performances of algorithms. Material and Methods: The data were collected from 185 patients older than 18 years of age who were admitted to Izmir Bozkaya Training and Research Hospital, Endocrinology and Metabolism Diseases outpatient clinic between June and September 2013. Under-sampling, over-sampling and synthetic minority over-sampling methods were used to eliminate unbalanced class problem for diagnosis of diabetes. The effects on classification performance were compared by integrating bagging and boosting methods into ensemble learning methods. Accuracy, Kappa statistics, sensitivity and specificity were used to compare correct classification performance of algorithms. All statistical analyzes were made in the R programming language, an open source software. Results: The success rate of diabetes diagnosis with raw data is very low in the unbalanced data set. It is determined that classifications made with over-sampling method have much more successful estimation power than classifications made with original unbalanced data set, under-sampling and synthetic minority over-sampling method. Conclusion: It is recommended to use classification algorithms after balancing the data by subjecting the data sets to resampling methods in the presence of class imbalance. [ABSTRACT FROM AUTHOR]

Objective: In this study, it is aimed to research how plasma miR-103 and miR-107 levels are related to insulin resistance changed when comparing obese children to healthy normal-weight children. Material and Method: The study was made on 40 obese children aged 5-17 and with 40 healthy normalweight children aged 5-17. Plasma miR-103 and miR- 107 expressions were analyzed using the Real Time-PCR method. Results: miR-103 and miR-107 values about an obese group were significantly found higher (p<0.001) than a control group. It was found a statistically significant level of positive correlation in obese children between miR-103 and body mass index (BMI) (p<0.001) and BMI-p (p<0.01), insulin (p<0.01) and HOMA-IR (p<0.01). Also, it was found the statistically significant level of positive correlation in obese children between miR-107 and BMI (p<0.01), and insulin (p<0.05) ve HOMA-IR (p<0.05). Conclusion: In the light of our findings, we can say that obesity increases plasma miR-103 and miR-107 levels in children and these microRNAs showed a positive correlation with parameter HOMA-IR used to evaluate insulin resistance and insulin. miR-103 and miR-107 can shed impressive progress for understanding glucose homeostasis, whether in normal physiology or human disease. [ABSTRACT FROM AUTHOR]

Objective: Education is the cornerstone of diabetes management, and numerous educational studies used Diabetes Knowledge Level Tests to determine the effectiveness of education. Our study was planned to adopt the revised Diabetes Knowledge Test (DKT2) of the Michigan Diabetes Research and Training Center for the Turkish population. Material and Methods: A total of 296 diabetic subjects using insulin were included in the study. After the determination of the validity of the language and content of the test, it was applied to the patients. The reliability of the study was assessed using Cronbach's alpha coefficient. The results of the DKT2 demographic values, and laboratory tests of the patients were noted. Results: Cronbach's alpha values were 0.60, 0.59, and 0.70 for the first part, second part, and complete test, respectively. The test-retest reliability values were 0.76 and 0.87 (p<0.001), respectively. The correct response rate to the first part was 32.68±2.47% in patients with Type 1 diabetes and 32.16±2.66% in patients with Type 2 diabetes using insulin. The correct response rate to the second part was 19.68±2.05% and 19.55±2.96%, respectively. Discussion: The Turkish adapted version of DKT2 is a reliable tool to measure patients' level of diabetes knowledge. However, in order to increase the level of knowledge of the patients, education of diabetes should be improved. [ABSTRACT FROM AUTHOR]

Copyright of Firat Universitesi Saglik Bilimleri Veteriner Dergisi is the property of Firat Universitesiu, Saglik Bilimleri Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Public Health is the property of Turkish Journal of Public Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Hamidiye Medical Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Giriş: Diyabetik ayak enfeksiyonu diyabetin önemli bir komplikasyonudur. Bu komplikasyonun gelişmesinde nöropati önemli rol oynar. Diyabeti olan hastaların yaklaşık %50'sinde hastalığın başlangıcından sonraki 25 yıl içinde semptomatik periferik nöropati gelişmektedir. Diyabetik nöropati, alt ekstremitelerin distalinden başlayan, ağrı ve ciddi morbidite ile karakterize olan duyusal fonksiyon kaybıdır. Periferik nöropatinin önlenmesi ve tedavisinde büyük ölçüde glisemik kontrol önemlidir. Ağrı yönetimi, kilo kaybı, yaşam tarzı değişiklikleri diyabetik nöropatinin tedavisinde önemli rol oynamaktadır. Tip 1 diyabetlilerde tanıdan 5 yıl sonra, tip 2 diyabetlilerde ise tanıdan itibaren başlamak suretiyle, her yıl nöropati taraması yapılması önerilmektedir. Diyabetik nöropatinin erken tanısı alt ekstremite ampütasyonları, kardiyak aritmiler dahil pek çok komplikasyonları önleyebilir. Çalışmamızda; Enfeksiyon hastalıkları ve klinik mikrobiyoloji kliniğinde diyabetik ayak enfeksiyonu nedeniyle yatırılarak tedavi alan nöroloji konsültasyonu planlanan hastaların elektromiyografi sonuçlarıyla nöropati açısından değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Kasım 2021 ve Mart 2024 tarihleri arasında kliniğimizde diyabetik ayak enfeksiyonu nedeniyle takip edilen 278 hasta dahil edildi. Hastaların nöroloji konsültasyonları ve elektromiyografi (EMG) raporları hastane bilgi sistemi üzerinden retrospektif olarak değerlendirildi. Çalışmanın etik kurul onayı alınmıştır. Bulgular: Çalışmamızda kliniğimizde diyabetik ayak nedeniyle takip edilen 278 hasta dahil edildi. Hastaların 197'si (%70,8) erkek, 81'i (%29,1) kadındı. Yaş ortalaması 62,2±11,5 idi. Hastaların 194'ünün (%69,7) diyabetik nöropati açısından nörolojiye konsülte edildiği görüldü. Yüz on hastaya (%39,6) EMG planlandı. EMG planlanan hastaların 105'inde (%95,4) sensorimotor nöropati saptandı. Sonuç: Diabetes mellitus dünya çapında 500 milyon insanı etkileyen önemli bir sağlık sorunudur. Diyabetik nöropati hem tip 1 hem de tip 2 diyabetin önemli mikrovasküler komplikasyonlarından biridir. Diyabetik nöropatisi olan hastalarda ayak deformitesi gelişmekte ve bu durum iskemiye yol açarak diyabetik ayak enfeksiyonlarının gelişmesine zemin hazırlamaktadır. Hastaların nöropati gelişimi açısından elektromiyografi ile değerlendirilmesi ve erken tanı ve tedavi için nörolojik muayenenin belirli aralıklarla yapılması gereklidir. [ABSTRACT FROM AUTHOR]

Giriş: Diabetes mellitus dünya çapında 170 milyon insanı etkileyen, tam/rölatif insülin eksikliği ve periferde insülinin etkisine karşı gelişen insülin direnci nedeniyle ortaya çıkan metabolik tablodur. Diyabetin komplikasyonları temel olarak mikrovasküler ve makrovasküler olmak üzere ikiye ayrılmaktadır. Büyük damarların tutulumu sonucu kalp, beyin ve ekstremitelerin etkilenmesi makrovasküler komplikasyonları oluşturmaktadır. Mikrovasküler komplikasyonları arasında ise retinopati, nöropati ve nefropati bulunmaktadır. Enfekte ya da iskemik diyabetik ayak ülseri, diyabetik hastalarda hastaneye yatışların %25'ini oluşturmaktadır. Risk faktörleri arasında nöropatiye bağlı gelişen duyu kaybı, daha önce geçirilmiş ülser/ampütasyon öyküsü, ayak deformitesi ve periferik damar hastalığı varlığı yer almaktadır. Diyabetik ayak nedeniyle takip edilen hastaların çoğunda periferik damar hastalığı mevcuttur. Kronik hiperglisemi vasküler komplikasyonlara neden olmakta ve doku perfüzyonunu bozmaktadır. Periferik vasküler sistem değerlendirmesinde fizik muayene ve görüntüleme yöntemleri önemli rol oynamaktadır. Diyabeti olan bireylerde periferik damar hastalığı gelişme riski daha yüksektir. İskemiye bağlı komplikasyonları önlemek için erken tanı ve multidisipliner tedavi yaklaşımı önemlidir. Gereç ve Yöntem: Çalışmaya Kasım 2021 ve Mart 2024 tarihleri arasında kliniğimizde diyabetik ayak enfeksiyonu nedeniyle yatırılarak takip edilen 278 hasta dahil edildi. Hastaların kalp damar cerrahisi konsültasyonları, alt ekstremite Doppler ultrasonu/bilgisayarlı tomografi anjiografi sonuçları hastane bilgi sistemi üzerinden retrospektif olarak değerlendirildi. Çalışmanın etik kurul onayı alınmıştır. Bulgular: Çalışmamızda kliniğimizde diyabetik ayak nedeniyle takip edilen 278 hasta değerlendirildi. Hastaların 197'si (%70,8) erkek, 81'i (%29,1) kadındı. Yaş ortalaması 62,2±11,5 idi. Hastaların 108'ine (%38,8) alt ekstremite Doppler ultrasonu veya alt ekstremite bilgisayarlı tomografi anjiyografi çekilmişti, 170'inin (%61,2) herhangi bir görüntülemesinin olmadığı görüldü. Doksan (%83) hastada vaskülopati olduğu saptandı. Çalışmaya dahil edilen 278 kişiden 88 kişi kalp damar cerrahisine konsülte edilirken 82 (%93,1) hastanın tedavisinin kalp damar cerrahisi tarafından revize edildiği görüldü. Hastalara sıklıkla klopidogrel, asetil salisilik asit ve silastazol tedavileri verilmişti. Sonuç: Periferik damar hastalığı diyabet hastalarında daha sık görülmekte ve iskemiye bağlı diyabetik ayak yarasına neden olmaktadır. Bir ekstremitede hayatı tehdit eden iskemi geliştiğinde beş yıl içinde hastaların yarısında kontralateral iskemi gelişmektedir. Multi disipliner bir yaklaşım ile tedavi edilmesi gereken bu hastaların kalp damar cerrahisi tarafından da yakından takibi komplikasyonları azaltmakta etkili olacaktır. [ABSTRACT FROM AUTHOR]

Giriş: Deri yumuşak doku enfeksiyonları, diyabeti olan hastalarda görülme sıklığı artmakla birlikte komplike seyir gösterebilmektedir. Karbonküller, birden fazla püy drenajının görüldüğü, ateş ve halsizlik gibi sistemik semptomların eşlik ettiği büyük ve ağrılı şişliklerdir. Yumuşak dokunun daha derin katmanlarını etkilerler ve yara izine neden olabilirler. Etken mikroorganizmalar genellikle Staphylococcus aureus, koagülaz negatif stafilokoklar, Streptococcus pyogenes ve diğer streptokoklardır. Bu olguda kontrolsüz diyabeti olan hastada hızla karbonküle ilerleyen, antibiyoterapi ve cerrahi drenaj ile iyileşen olguyu sunmayı amaçladık. Olgu: Elli dört yaşında kadın hasta, acil servise bir aydır sırtta şişlik, ağrı ve ateş şikayeti ile başvurdu. Öncesinde sağlık kuruluşuna başvuru öyküsü ve antibiyoterapi kullanma öyküsü yoktu. Torakolomber bölgede ekimotik, ödemli, sert, multipl odaklardan minimal drenajı olan, yaklaşık 15x15 cm boyutlarında sert ağrılı şişliği vardı. Acil serviste ateş: 38,3 °C, tansiyon: 130/80 mmHg, nabız 100/dk olduğu görüldü. Kan glukozu 365 mg/dl çıkan hastanın takipsiz diyabet hastası olduğu öğrenildi. Mevcut lezyon dışında sistem sorgusunda ve fizik muayenede ek özellik saptanmadı. Tetkiklerinde C-reaktif protein 16,27 mg/dl, sedimentasyon 94 mm/saat, beyaz küre 16490 mm3 olarak sonuçlandı. Acil cerrahi girişim düşünülmeyen, acil servis yüzeyel ultrasonografi (USG) ve bilgisayarlı tomografi görüntülemelerinde sıvama tarzı mayi görülen ve apse izlenmeyen hastaya karbonkül ve komplike yumuşak doku enfeksiyonu ön tanıları ile yatış verildi. Piperasilin-tazobaktam, teikoplanin, klindamisin tedavilerine başlandı. Takiplerinin üçüncü gününde antibiyoterapi altında kontrol yüzeyel USG görüntülemesinde deri planları arasında mayii artışı izlendi. Drenaj amaçlı üç cm vertikal insizyon yapıldı. Yaklaşık 500 cc'ye yakın pürülan mayii boşaltıldı. Drenaj materyalinden gönderilen kültürde metisilin duyarlı S. aureus üremesi oldu. Kan kültürlerinde üreme olmadı. Mevcut tedavileri kesilerek ampisilin-sulbaktam tedavisine geçildi. Mevcut insizyon hattından spontan drenaja bırakıldı ve günlük pansumanları yapıldı. S. aureus'a bağlı metastatik odak saptanmadı. C-reaktif protein 0,32 mg/dl'ye, sedimentasyon 76 mm/saat'e geriledi. Yirmi bir gün iv antibiyoterapi ve günlük yara bakımı ile takip edilen hastanın lezyonu belirgin geriledi. Taburculuğu planlandı. Bir hafta oral antibiyoterapi ile tedavisi tamamlandı. Sonuç: Karbonkül tedavisinde, etkin cerrahi müdahale, etkene yönelik uygun antibiyoterapi ve kan şekeri regülasyonu sağlanmalıdır. Lezyonun erken sıkılmasından kaçınılmalı, fluktuasyon aşamasındayken insizyon ve drenaj yapılmalıdır. İğne aspirasyonu yumuşak doku apselerinde daha başarılı olup karbonküllerde lineer insizyon önerilmektedir. [ABSTRACT FROM AUTHOR]

Amaç: Epidemiyolojik araştırmalar periferik kandaki lökosit sayısı ile Tip 2 Diyabetes Mellitus (T2DM) arasında ilişki bulunduğunu göstermesine rağmen bu ilişki sistematik olarak incelenmemiştir. Bu çalışmada, T2DM tanısı olan hastaların (T2DM(+)) lökosit sayımı ve biyokimya tetkik sonuçlarının diyabeti olmayan hastaların (T2DM(-)) sonuçlarıyla karşılaştırılması amaçlanmıştır.Materyal ve Metot: Çalışmaya; 02.02.2015-30.09.2015 tarihleri arasında Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Aile Hekimliği Poliklinikleri’ne başvuran hastalar alınmıştır. Hastaların antropometrik ölçümleri, tam kan sayımı ve biyokimyasal testlerinin sonuçları kaydedilmiştir ve bu değerler T2DM(+) ile T2DM(-) grupları arasında karşılaştırılmıştır.Bulgular: Çalışmaya dâhil edilen 286 hastanın yaş ortalaması 58,7±10,5 yıl olarak saptandı. T2DM(+) (n=108) ve T2DM(-) (n=178) gruplarının yaş ve cinsiyet dağılımları arasında fark yoktu. T2DM(+) grubun ortalama lökosit sayısının T2DM(-) grubundan yüksek olduğu saptandı (7,73 × 103/ml; 7,17 × 103/ml; p=0,001). T2DM(+) grubun bel çevresi, vücut kitle indeksi (VKİ), açlık kan şekeri (AKŞ), alanin aminotransferaz (ALT) ve trigliserid değerleri T2DM(-) grubuna göre anlamlı olarak yüksek olduğu, düşük yoğunluklu kolesterol (LDL) ve yüksek yoğunluklu kolesterol (HDL) değerlerinin ise anlamlı olarak daha düşük olduğu bulundu. Sonuç: Lökosit sayısı normal sınırlar içerisinde dahi T2DM hastalarında diyabeti olmayan bireylerden daha yüksektir. Bizim sonuçlarımız kronik inflamasyonun Tip 2 diyabetteki rolünü desteklemektedir. İnflamasyonun diyabetteki rolünü açıklayacak daha kapsamlı çalışmalara ihtiyaç vardır.

In the integrated approach, in which complementary practices are combined with modern medicine, the aim is to create a healing environment, to raise awareness of the individual and to reveal the self-healing potential. Scientific work on the therapeutic effect of Reiki administration on glucosone control in reducing anxiety and stress, increasing quality of life in diabetic patients is extremely scarce. This study was compiled to be both informative and helpful to subsequent studies due to the lack of studies about the effects of Reiki in the treatment of diabetic patients.

Objective: In this study, we aimed to evaluate the association of lower urinary tract symptoms (LUTS), overactive bladder (OAB) and urinary incontinence (UI) with age, diabetic complications and glycaemic control in diabetic women. Materials and Methods: A total of 81 women diagnosed with Diabetes Mellitus were included in the study. Demographic characteristics including age, height and weight of patients, full medical history, urine culture, serum creatinine levels and glycaemic control parameters including serum fasting blood glucose levels, serum satiety blood glucose levels and serum HbA1c levels. Turkish version of the OAB-V8, urinary distress inventory-6 (UDI-6), incontinence impact questionnaire (IIQ-7) and the International Prostate Symptom Score (IPSS) were applied. Results: The mean age was 58.6±11.8 years. Thirty-five (43.2%) of the patients had diabetes-related complications. There was no statistically significant relationship between OAB-V8, UDI-6, IPSS, IIQ-7 questionnaire scores and glycaemic control parameters, age, and presence of diabetic complications. Conclusion: To better understand the etiopathogenesis of diabetic bladder dysfunction and related complications including LUTS, OAB and UI, we need randomized controlled studies with a greater number of patients. [ABSTRACT FROM AUTHOR]

Rumex crispus is a natural, wild plant that grows spontaneously on riverside and wet meadows, and has been used for centuries in alternative medicine. In the present study, the effects of R. crispus on body weights, fasting blood glucose levels, plasma lipid profile, liver enzyme activities and antioxidant system were investigated in streptozotocin (STZ) induced diabetic rats. The animals were divided into 4 groups. Group I: control; group II: 3 mg kg-1 R. crispus; group III: 50 mg kg-1 Streptozotocin (STZ)-induced diabetes; group IV: 50 mg kg-1 STZ-induced diabetes + 3 mg kg-1 R.crispus. It was found that R. crispus extract reduced diabetesrelated weight loss and blood glucose levels 10 days after the formation of diabetes. At the end of 14-day treatment period, HDL cholesterol (HDL-C) levels significantly decreased (P<0.01) while triglyceride, LDL cholesterol (LDL-C) and VLDL cholesterol (VLDL-C) levels increased in R. crispus supplemented diabetic rats (P<0.001). The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly increased in response to R. crispus (P <0.001). Total antioxidant status (TAS) significantly decreased and total oxidant status (TOS) increased in diabetic group; however, in response to R. crispus treatment, TAS significantly increased and TOS decreased relative to control group (P<0.001, for both). Supplementation of R. crispus extract shows antidiabetic properties in rats and might have a clinical potential for diabetic individuals. [ABSTRACT FROM AUTHOR]

Objectives: The present study aimed to investigate the inhibitory activities of enzymes related to diabetes mellitus and Alzheimer's disease of the methanol and water extracts of Ficus carica leaf extracts. The bioactive compounds and anticancer, antioxidant, and antimicrobial effects of the extracts were also investigated. Materials and Methods: The bioactive compounds in the extracts were determined by gas chromatography-mass spectrometry. The antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6 sulphonic acid) (ABTS) radical scavenging, total phenol and flavonoid content, ferric reducing power, and iron chelating method. The anticancer, anticholinesterase, and antimicrobial effects were investigated using the XTT assay, Ellman method, and microdilution, respectively. Results: Our results showed that between the water and methanol extracts there was a difference in terms of chemical composition. The antioxidant results suggested that both extracts have strong antioxidant activity. Similarly, both extracts showed strong α-glucosidase and α-amylase inhibition activity, while the water extract had higher inhibition activity than the methanol extract against acetylcholinesterase and butyrylcholinesterase. The methanol extract of F. carica exhibited significant anticancer activity on MDA-MB-231 cells and showed moderate antimicrobial activities against Escherichia coli and Staphylococcus aureus. Conclusion: Our results suggest that F. carica leaves could be a valuable source for developing a promising therapeutic agent in cancer, diabetes, and Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Obstetrics & Gynecology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: In this work, peptide based antiglycation agents from various sources against the advanced glycation endproducts (AGE) formation was investigated. Materials and methods: As a source of peptides with deglycating activity, Glycine max, Hordeum vulgare, Triticum aestivum, Avena sativa, Prunus dulcis ve Juglans regia were used. The metal chelating activity and antioxidant activity were determined by Cu(II) chelating activity and CUPRAC (Cupric Reducing Antioxidant Capacity) methods. Antidiabetic activity was evaluated through BSA-glucose model. Results: Most of the extracts obtained have inhibitory activity against AGE formation. Among all plant peptide isolates soybean was found to be most efficient by means of antiglycating (IC50 1.33 µg/mL), antioxidant (28.2 ± 1.4 µmol AAE/mg) and metal chelation activity (55%). Conclusion: As a result, this study can provide preliminary data to literature to support researches those focused on peptide based glycation inhibitors and discovery of potent AGE inhibitory peptides. [ABSTRACT FROM AUTHOR]

Background: Diabetes is a complex and progressive disease and its treatment requires self-management strategies specific for each patient. The aim of the study was to determine perceived barriers to diabetes management at home in type II diabetes patients. Materials and methods: Inclusion criteria of this phenomenological study included living in İzmir and a diagnosis for the last 1 year; 15 patients with diabetes participated the study. A semi-structured interview form based on Health Belief Model created by researchers with experts opinion, was used at in-depth face-to-face interviews. Data were analyzed with content analysis. Ethical and hospital approval was obtained. Participation of individuals is based on volunteerism; written informed consent from patients who accepted the study. Results: Perceived barriers to fulfilling home care needs and sustaining behavior of diabetes management included six themes, i.e. insufficient knowledge of diabetes, inability to accept diabetes, non-adherence to diabetes and exercise, problems with health care services, fear and effects of the family and the society and relevant subthemes. Conclusion: These findings about the barriers of the patients should provide guidance for patient specific nursing interventions. [ABSTRACT FROM AUTHOR]

Objective: In diabetes mellitus, HbA1c is used as an indicator for metabolic control and shows the average of blood glucose levels over the past three months. Long-term benefits of diabetes education on metabolic control, emotional state and self-care have been shown. In this study, we have compared HbA1c levels measured before and after diabetes congress and summer school and aimed to investigate the effect of the training program on metabolic control. Methods: Diabetes education was provided for diabetic children, their families and adults that attended diabetes congress and summer school. HbA1c levels of the participants were measured before and after diabetes education. For patients followed from another clinics, declared HbA1c values were accepted. Results: Fifty-seven individuals among 91 diabetic patients who attended the Diabetes Congress were included in the study Fifty-eight diabetic patents participated in summer school. Average HbA1c levels of the participants before, and after the congress were found to be 8.88%, and 8.76%, respectively. Average HbA1c levesl were found to be 9.94%, and 9.6% before, and after the summer school trainings, respectively. There was no statistical significant differences between the HbA1c values before and after the education programmes. Conclusion: In diabetic individuals good HbA1c values were targeted to reduce complications. In order to achieve this goal, it is necessary to increase the motivation of the individuals, to repeat, and sustain the diabetes education programs of the patients and their families. [ABSTRACT FROM AUTHOR]

Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica, belonging to this genus, is widely distributed in Eastern Anatolia as well as in Caucasia, northern and northeastern Iran, and northern Iraq. Materials and Methods: Methanolic-water extracts of the aerial parts and roots of A. persica were evaluated for their hypoglycemic activities in mice with alloxan-induced diabetes in order to verify its usage in folk medicine. Results: None of the tested extracts exhibited a significant lowering effect on blood glucose levels. However, the aerial parts notably increased blood glucose levels at doses of 100 mg/kg and 200 mg/kg. Conclusion: A. persica usage as an antidiabetic is not confirmed in the present study. [ABSTRACT FROM AUTHOR]

Purpose: Fasting during Ramadan is a religious obligation for Muslims. Extended fasting can create undesirable acute complications of diabetes such as hypoglycemia or hyperglycemia. In this study, we aimed to evaluate the impact of fasting on glucose regulation in diabetic patients who fast during Ramadan. Materials and Methods: Patients were informed about the possible side effects of fasting for them and those who stated that they will be fasting during Ramadan were called one month after Ramadan. In this retrospective cohort study by telephone interview, the number of fasting days, daily measurements of glucose, the number of acute complications if existed and whether the patients have changed their treatments were asked. Results: Forty six patients were included in this study. Mean age was 54.3±9.5 yr. The average fasting day was 25.24±2.4. They were categorized according to the risk stratifications. The number of hypoglycemic events was not higher than detected six months prior to the Ramadan. Most of the patients had hyperglycemia rather than hypoglycemia. All of the patients who had hypo-or hyperglycemia did not interrupt their fasting and did not change their medications. Conclusion: Patients who fasted during Ramadan have a tendency both hypoglycemia and hyperglycemia. To improve glycemic regulation and keep these patients in a safe and acceptable glucose range, Pre-Ramadan education is necessary. [ABSTRACT FROM AUTHOR]

Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies distinguished by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. Extracts of the V. album leaves was reported to exert a beneficial effect to alleviate the symptoms of diabetes in local medicines. The aim of present investigation is to evaluate the antidiabetic and antioxidant activities of V. album extracts on streptozotocin (STZ) induced diabetic rats. Thirty two female Wistar albino rats, aging 6-7 weeks, were included in the present study. The rats were randomly divided into 4 groups: Group I (Control), Group II (V. album), Group III (Diabeteic), Group IV (Diabetic + V. album). After experimental period, all animals were decapitated, blood was collected and sera were separated. Serum concentrations of total cholesterol, high density lipoprotein, cholesterol, triglyceride, folic acid, vitamin D, vitamin B12 and glucose were determined by using automatic analyzer. Total Antioxidant Capacity (TAC) and Total Oxidative Status (TOS) analyses were measured ELISA. The levels of glucose (p≤0.05), vitamin B12 (p≤0.05), TOS (p≤0.05) were significantly decreased and TAC (p≤0.05) increased in diabetic+V. album group compared to diabetic group. In conclusion extracts of V. album have antidiabetic effects that significantly decreased glucose level when treated with V. album only 20 days of experiment. Viscum album had a stronge antioxidant activity that can help to prevent the formation of diabetic complications. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diabetic patients may experience more severe Staphylococcus aureus-related respiratory tract infections such as necrotizing pneumonia (NP). A 13-year-old girl with uncontrolled diabetes mellitus was admitted to pediatric intensive care unit (PICU) with diabetic ketoacidosis and respiratory distress. Her initial evaluation revealed diffuse pneumonic infiltration that progressed to NP within days. She was intubated and placed on mechanical ventilator (MV) support. Positive inotropes and broad-spectrum antibiotics were initiated. Methicillinresistant S. aureus was isolated from blood and pleural specimen cultures. In spite of aggressive medical treatment, infection could not be controlled and lobectomy was performed. However, the patient was fistulized and right total pneumonectomy was performed on the 16th and 29th days of PICU admission. She gradually got better and was weaned from MV. On the 59th day, she was discharged oxygen-free from the hospital. Early surgical intervention should be considered for the treatment of NP resistant to medical therapy. [ABSTRACT FROM AUTHOR]

Introduction: Diabetes is associated with anxiety and depression. Resveratrol, one of the most potent natural polyphenols with antioxidant properties, has been demonstrated to have benefits against diabetes. In the current study, we investigated the effects of resveratrol on depression and anxiety-like behaviors in diabetic rats. Methods: Adult male Wistar albino rats were assigned for control and diabetic groups, and these groups were divided into four subgroups as follows: Saline-treated, DMSO-treated, resveratrol-treated and imipramine-treated animals (n=10). Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg), and 2 days after the STZ injection the rats having hyperglycemia (>300 mg/ dl) were assigned to be diabetic. Rats in treatment groups were injected intraperitoneally with resveratrol (20 mg/kg) and imipramine (10 mg/ kg) for 4 weeks. After 4-week-treatment period, tail suspension test (TST), forced swimming test (FST), elevated plus maze test (EPM) and locomotor activity test were performed. Blood samples were collected to estimate serum superoxide dismutase (SOD) and NADPH oxidase (Nox) levels. Results: Diabetic rats displayed depressive-like behaviors in the FST and TST, and anxiety-like behaviors in the EPM. Resveratrol and imipramine decreased anxiety-like and depressive-like behaviors without affecting locomotor activity in diabetic rats. A significant reduction in SOD levels and a marked increase in Nox levels were observed in diabetic rats. Resveratrol treatment normalized these levels, while imipramine did not affect neither SOD nor Nox levels. Conclusion: This study indicates that chronic resveratrol treatment may able to treat comorbid anxiety-and depressive-like behaviors in diabetes through inhibition of oxidative stress. [ABSTRACT FROM AUTHOR]