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681 results on '"Diekmann, F."'

182. Pharmacodynamic monitoring of lymphocyte proliferation and TGF-β1 expression at cyclosporine a (CyA) trough levels (C0) and 2 hours after intake (C2) of CyA in human renal allograft recipients

Author

Böhler, T., primary, Budde, K., additional, Schneider, M., additional, Eliazyfer, S., additional, Dell, K., additional, Einecke, G., additional, Diekmann, F., additional, Fritsche, L., additional, Mai, I., additional, Neumayer, H.H., additional, and Waiser, J., additional

Published
2001
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194. Near-infrared laser computed tomography of the breast first clinical experience.

Author

Poellinger A, Martin JC, Ponder SL, Freund T, Hamm B, Bick U, Diekmann F, Poellinger, Alexander, Martin, Jan C, Ponder, Steven L, Freund, Torsten, Hamm, Bernd, Bick, Ulrich, and Diekmann, Felix

Abstract

Rationale and Objectives: The purpose of the present study was to evaluate a near-infrared (NIR) laser breast imaging system (Computed Tomography Laser Mammography [CTLM]) as an adjunct to mammography by means of receiver-operating characteristic (ROC) analysis. The NIR technique used in this study is based on the absorption of NIR light by hemoglobin. Malignant tumors can be detected by imaging their neovascularization. Materials and Methods: Eighty-two patients were examined by both CTLM and mammography. Seventy-nine of the 82 patients underwent biopsies, and three patients had 2-year follow up. Three-dimensional scans were acquired with an NIR laser computed tomographic scanner (the CTLM system) at a slice thickness of 4 mm. Mammograms were analyzed alone and together with CTLM images. Results: Histology revealed 37 benign and 42 malignant lesions. For the combination of mammography and CTLM, the area under the ROC curve was significantly larger than for mammography alone. In addition, it was shown that the difference in area under the ROC curve between the combination of both methods and mammography alone was considerably larger for dense breasts than for radiolucent breasts, although these differences were not statistically significant. Conclusion: CTLM, used as an adjunct, may serve as a feasible tool to improve the diagnostic capabilities of mammography. [ABSTRACT FROM AUTHOR]

Published
2008
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195. Observer variability in screen-film mammography versus full-field digital mammography with soft-copy reading.

Author

Skaane P, Diekmann F, Balleyguier C, Diekmann S, Piguet JC, Young K, Abdelnoor M, Niklason L, Skaane, Per, Diekmann, Felix, Balleyguier, Corinne, Diekmann, Susanne, Piguet, Jean-Charles, Young, Kari, Abdelnoor, Michael, and Niklason, Loren

Abstract

Full-field digital mammography (FFDM) with soft-copy reading is more complex than screen-film mammography (SFM) with hard-copy reading. The aim of this study was to compare inter- and intraobserver variability in SFM versus FFDM of paired mammograms from a breast cancer screening program. Six radiologists interpreted mammograms of 232 cases obtained with both techniques, including 46 cancers, 88 benign lesions, and 98 normals. Image interpretation included BI-RADS categories. A case consisted of standard two-view mammograms of one breast. Images were scored in two sessions separated by 5 weeks. Observer variability was substantial for SFM as well as for FFDM, but overall there was no significant difference between the observer variability at SFM and FFDM. Mean kappa values were lower, indicating less agreement, for microcalcifications compared with masses. The lower observer agreement for microcalcifications, and especially the low intraobserver concordance between the two imaging techniques for three readers, was noticeable. The level of observer agreement might be an indicator of radiologist performance and could confound studies designed to separate diagnostic differences between the two imaging techniques. The results of our study confirm the need for proper training for radiologists starting FFDM with soft-copy reading in breast cancer screening. [ABSTRACT FROM AUTHOR]

Published
2008
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196. In patients with DCIS: is it sufficient to histologically examine only those tissue specimens that contain microcalcifications?

Author

Poellinger A, Diekmann S, Dietz E, Bick U, Diekmann F, Poellinger, Alexander, Diekmann, Susanne, Dietz, Ekkehart, Bick, Ulrich, and Diekmann, Felix

Abstract

The purpose was to investigate in patients with histologically proven DCIS to what extent there is agreement between radiographically proven microcalcifications of specimens obtained by vacuum-assisted biopsy and the histologic diagnosis of microcalcifications and DCIS, and second, to assess the accuracy of biopsy in relation to the number of specimens obtained in patients with high-grade and low-grade DCIS. Four hundred twenty specimens from 35 patients who were diagnosed with DCIS were examined radiographically and histologically for the presence of microcalcifications. The results were analyzed using the McNemar-test. In addition, the average numbers of biopsy specimens necessary for diagnosing low-grade DCIS and high-grade DCIS were compared using the t-test. Specimen radiography had a PPV of 0.50 and a NPV of 0.85 for the demonstration of DCIS. Differences in localization between radiographically proven microcalcifications and DCIS were statistically significant (p<0.01). The difference between the mean numbers of specimens required per patient for correctly diagnosing high-grade or low-grade DCIS was statistically significant (p<0.01). Specimen radiography is very limited in identifying those specimens that are crucial for diagnosing DCIS. The rate of underestimation is expected to be higher for low-grade than for high-grade DCIS. The findings suggest that all samples obtained by vacuum-assisted breast biopsy should be histologically examined. [ABSTRACT FROM AUTHOR]

Published
2008
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199. On the sampling of airborne reflectance measurements above broken cloud fields.

Author

Diekmann, F. and Raschke, E.

Abstract

Copyright of Theoretical & Applied Climatology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1986
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