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151. Subtyping on Nested Polymorphic Session Types

Author: Das, Ankush, DeYoung, Henry, Mordido, Andreia, and Pfenning, Frank
Subjects: Computer Science - Programming Languages, Computer Science - Logic in Computer Science
Abstract: The importance of subtyping to enable a wider range of well-typed programs is undeniable. However, the interaction between subtyping, recursion, and polymorphism is not completely understood yet. In this work, we explore subtyping in a system of nested, recursive, and polymorphic types with a coinductive interpretation, and we prove that this problem is undecidable. Our results will be broadly applicable, but to keep our study grounded in a concrete setting, we work with an extension of session types with explicit polymorphism, parametric type constructors, and nested types. We prove that subtyping is undecidable even for the fragment with only internal choices and nested unary recursive type constructors. Despite this negative result, we present a subtyping algorithm for our system and prove its soundness. We minimize the impact of the inescapable incompleteness by enabling the programmer to seed the algorithm with subtyping declarations (that are validated by the algorithm). We have implemented the proposed algorithm in Rast and it showed to be efficient in various example programs.
Published: 2021

152. Pathogenesis of obstructive sleep apnea in people living with HIV

Author: Orr, Jeremy E, Edwards, Bradley A, Schmickl, Christopher N, Karris, Maile, DeYoung, Pamela N, Darquenne, Chantal, Theilmann, Rebecca, Jain, Sonia, Malhotra, Atul, Hicks, Charles B, and Owens, Robert L
Subjects: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Sleep Research, Behavioral and Social Science, Prevention, Infectious Diseases, Lung, Body Mass Index, HIV Infections, Humans, Middle Aged, Polysomnography, Sleep, Sleep Apnea, Obstructive, fatigue, HIV, obstructive sleep apnea, Biological Sciences, Medical and Health Sciences, Physiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract: Obstructive sleep apnea (OSA) is highly prevalent in people living with human immunodeficiency virus (HIV) (PLWH), and it might contribute to frequently reported symptoms and comorbidities. Traditional risk factors for OSA are often absent in PLWH, suggesting that HIV or HIV medications might predispose to OSA. Therefore, we measured the anatomical and nonanatomical traits important for OSA pathogenesis in those with and without HIV. We recruited virally suppressed PLWH who had been previously diagnosed with OSA (PLWH + OSA) adherent to positive airway pressure (PAP) therapy, along with age-, sex-, and body mass index (BMI)-matched OSA controls. All participants underwent a baseline polysomnogram to assess OSA severity and a second overnight research sleep study during which the airway pressure was adjusted slowly or rapidly to measure the OSA traits. Seventeen PLWH + OSA and 17 OSA control participants were studied [median age = 58 (IQR = 54-65) yr, BMI = 30.7 (28.4-31.8) kg/m2, apnea-hypopnea index = 46 (24-74)/h]. The groups were similar, although PLWH + OSA demonstrated greater sleepiness (despite PAP) and worse sleep efficiency on baseline polysomnography. On physiological testing during sleep, there were no statistically significant differences in OSA traits (including Veupnea, Varousal, Vpassive, Vactive, and loop gain) between PLWH + OSA and OSA controls, using mixed-effects modeling to account for age, sex, and BMI and incorporating each repeated measurement (range = 72-334 measures/trait). Our data suggest that well-treated HIV does not substantially impact the pathogenesis of OSA. Given similar underlying physiology, existing available therapeutic approaches are likely to be adequate to manage OSA in PLWH, which might improve symptoms and comorbidities.NEW & NOTEWORTHY Clinical data suggest an increased risk of obstructive sleep apnea (OSA) in people living with HIV (PLWH), while OSA might account for chronic health issues in this population. We characterized the anatomical and nonanatomical OSA traits in PLWH + OSA compared with OSA controls, using detailed physiological measurements obtained during sleep. Our data suggest against a major impact of HIV on OSA pathogenesis. Available OSA management strategies should be effective to address this potentially important comorbidity in PLWH.
Published: 2021

153. A Convolutional Neural Network based Cascade Reconstruction for the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mari{ş}, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morik, K., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguy{\~{ê}}n, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Valtonen-Mattila, N., Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: High Energy Physics - Experiment, Computer Science - Machine Learning
Abstract: Continued improvements on existing reconstruction methods are vital to the success of high-energy physics experiments, such as the IceCube Neutrino Observatory. In IceCube, further challenges arise as the detector is situated at the geographic South Pole where computational resources are limited. However, to perform real-time analyses and to issue alerts to telescopes around the world, powerful and fast reconstruction methods are desired. Deep neural networks can be extremely powerful, and their usage is computationally inexpensive once the networks are trained. These characteristics make a deep learning-based approach an excellent candidate for the application in IceCube. A reconstruction method based on convolutional architectures and hexagonally shaped kernels is presented. The presented method is robust towards systematic uncertainties in the simulation and has been tested on experimental data. In comparison to standard reconstruction methods in IceCube, it can improve upon the reconstruction accuracy, while reducing the time necessary to run the reconstruction by two to three orders of magnitude., Comment: 39 pages, 15 figures, submitted to Journal of Instrumentation; added references
Published: 2021
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154. IceCube Data for Neutrino Point-Source Searches Years 2008-2018

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Campana, M. A., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., Zhang, Z., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: IceCube has performed several all-sky searches for point-like neutrino sources using track-like events, including a recent time-integrated analysis using 10 years of IceCube data. This paper accompanies the public data release of these neutrino candidates detected by IceCube between April 6, 2008 and July 8, 2018. The selection includes through-going tracks, primarily due to muon neutrino candidates, that reach the detector from all directions, as well as neutrino track events that start within the instrumented volume. An updated selection and reconstruction for data taken after April 2012 slightly improves the sensitivity of the sample. While more than 80% of the sample overlaps between the old and new versions, differing events can lead to changes relative to the previous 7 year event selection. An a posteriori estimate of the significance of the 2014-2015 TXS flare is reported with an explanation of observed discrepancies with previous results. This public data release, which includes 10 years of data and binned detector response functions for muon neutrino signal events, shows improved sensitivity in generic time-integrated point source analyses and should be preferred over previous releases., Comment: See https://icecube.wisc.edu/science/data/PS-IC40-IC86_VII for the associated data release files. For the associated time-integrated analysis results, see Phys. Rev. Lett. 124, 051103 (2020) (also available at arXiv:1910.08488)
Published: 2021
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155. Search for GeV Neutrino Emission During Intense Gamma-Ray Solar Flares with the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Günther, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Valtonen-Mattila, N., Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract: Solar flares convert magnetic energy into thermal and non-thermal plasma energy, the latter implying particle acceleration of charged particles such as protons. Protons are injected out of the coronal acceleration region and can interact with dense plasma in the lower solar atmosphere, producing mesons that subsequently decay into gamma rays and neutrinos at O(MeV-GeV) energies. We present the results of the first search for GeV neutrinos emitted during solar flares carried out with the IceCube Neutrino Observatory. While the experiment was originally designed to detect neutrinos with energies between 10 GeV and a few PeV, a new approach allowing for a O(GeV) energy threshold will be presented. The resulting limits allow us to constrain some of the theoretical estimates of the expected neutrino flux., Comment: 28 pages, 7 figures, 3 tables
Published: 2021
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156. LeptonInjector and LeptonWeighter: A neutrino event generator and weighter for neutrino observatories

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Valtonen-Mattila, N., Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: Physics - Computational Physics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: We present a high-energy neutrino event generator, called LeptonInjector, alongside an event weighter, called LeptonWeighter. Both are designed for large-volume Cherenkov neutrino telescopes such as IceCube. The neutrino event generator allows for quick and flexible simulation of neutrino events within and around the detector volume, and implements the leading Standard Model neutrino interaction processes relevant for neutrino observatories: neutrino-nucleon deep-inelastic scattering and neutrino-electron annihilation. In this paper, we discuss the event generation algorithm, the weighting algorithm, and the main functions of the publicly available code, with examples., Comment: 28 pages, 10 figures, 3 tables
Published: 2020
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157. Follow-up of astrophysical transients in real time with the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: In multi-messenger astronomy, rapid investigation of interesting transients is imperative. As an observatory with a 4$\pi$ steradian field of view and $\sim$99\% uptime, the IceCube Neutrino Observatory is a unique facility to follow up transients, and to provide valuable insight for other observatories and inform their observing decisions. Since 2016, IceCube has been using low-latency data to rapidly respond to interesting astrophysical events reported by the multi-messenger observational community. Here, we describe the pipeline used to perform these follow up analyses and provide a summary of the 58 analyses performed as of July 2020. We find no significant signal in the first 58 analyses performed. The pipeline has helped inform various electromagnetic observing strategies, and has constrained neutrino emission from potential hadronic cosmic accelerators., Comment: 18 pages, 9 figures
Published: 2020
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158. A search for time-dependent astrophysical neutrino emission with IceCube data from 2012 to 2017

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: High-energy neutrinos are unique messengers of the high-energy universe, tracing the processes of cosmic-ray acceleration. This paper presents analyses focusing on time-dependent neutrino point-source searches. A scan of the whole sky, making no prior assumption about source candidates, is performed, looking for a space and time clustering of high-energy neutrinos in data collected by the IceCube Neutrino Observatory between 2012 and 2017. No statistically significant evidence for a time-dependent neutrino signal is found with this search during this period since all results are consistent with the background expectation. Within this study period, the blazar 3C 279, showed strong variability, inducing a very prominent gamma-ray flare observed in 2015 June. This event motivated a dedicated study of the blazar, which consists of searching for a time-dependent neutrino signal correlated with the gamma-ray emission. No evidence for a time-dependent signal is found. Hence, an upper limit on the neutrino fluence is derived, allowing us to constrain a hadronic emission model.
Published: 2020
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159. Facial emotion recognition and mood symptom course in young adults with childhood-onset bipolar disorder

Author: MacPherson, Heather A, Kudinova, Anastacia Y, Jenkins, Gracie A, Kim, Kerri L, Radoeva, Petya D, Gilbert, Anna C, Barthelemy, Christine, DeYoung, Lena, Yen, Shirley, Hower, Heather, Hunt, Jeffrey, Keller, Martin B, and Dickstein, Daniel P
Subjects: Biological Psychology, Clinical and Health Psychology, Psychology, Serious Mental Illness, Depression, Brain Disorders, Bipolar Disorder, Mind and Body, Clinical Research, Pediatric, Behavioral and Social Science, Mental Health, Mental health, Adolescent, Adult, Emotions, Facial Recognition, Female, Humans, Male, Young Adult, Bipolar disorder, Face processing, Emotion recognition, Prediction, Child, Young adult, Clinical Sciences, Neurosciences, Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology
Abstract: Facial emotion recognition deficits are common in bipolar disorder (BD) and associated with impairment. However, the relationship between facial emotion recognition and mood course is not well understood. This study examined facial emotion recognition and subsequent mood symptoms in young adults with childhood-onset BD versus typically developing controls (TDCs). The sample included 116 young adults (ages 18-30, 58% male, 78% White) with prospectively verified childhood-onset BD (n = 52) and TDCs (n = 64). At baseline, participants completed a facial emotion recognition task (Diagnostic Analysis of Non-Verbal Accuracy-2) and clinical measures. Then, participants with BD completed mood symptom assessments every 6 months (M = 8.7 ± 5.2 months) over two years. Analyses included independent-samples t tests and mixed-effects regression models. Participants with BD made significantly more recognition errors for child expressions than TDCs. There were no significant between-group differences for recognition errors for adult expressions, or errors for specific child or adult emotional expressions. Participants had moderate baseline mood symptoms. Significant time-by-facial emotion recognition interactions revealed more recognition errors for child emotional expressions predicted lower baseline mania and stable/consistent trajectory; fewer recognition errors for child expressions predicted higher baseline mania and decreasing trajectory. In addition, more recognition errors for adult sad expressions predicted stable/consistent depression trajectory and decreasing mania; fewer recognition errors for adult sad expressions predicted decreasing depression trajectory and stable/consistent mania. Effects remained when controlling for baseline demographics and clinical variables. Facial emotion recognition may be an important brain/behavior mechanism, prognostic indicator, and intervention target for childhood-onset BD, which endures into young adulthood and is associated with mood trajectory.
Published: 2021

160. Search for Multi-flare Neutrino Emissions in 10 yr of IceCube Data from a Catalog of Sources

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, AA, Amin, NM, An, R, Andeen, K, Anderson, T, Anton, G, Argüelles, C, Ashida, Y, Axani, S, Bai, X, V., A Balagopal, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Boddenberg, M, Bontempo, F, Borowka, J, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Browne, S, Burgman, A, Burley, RT, Busse, RS, Campana, MA, Carnie-Bronca, EG, Chen, C, Chirkin, D, Choi, K, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dappen, C, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dittmer, M, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Erpenbeck, H, Evans, J, Evenson, PA, Fan, KL, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, and Fischer, L
Subjects: Particle and High Energy Physics, Physical Sciences, Astronomical and Space Sciences, Astronomy & Astrophysics, Astronomical sciences, Space sciences
Abstract: A recent time-integrated analysis of a catalog of 110 candidate neutrino sources revealed a cumulative neutrino excess in the data collected by IceCube between 2008 April 6 and 2018 July 10. This excess, inconsistent with the background hypothesis in the Northern Hemisphere at the 3.3σ level, is associated with four sources: NGC 1068, TXS 0506+056, PKS 1424+240, and GB6 J1542+6129. This Letter presents two time-dependent neutrino emission searches on the same data sample and catalog: a point-source search that looks for the most significant time-dependent source of the catalog by combining space, energy, and time information of the events, and a population test based on binomial statistics that looks for a cumulative time-dependent neutrino excess from a subset of sources. Compared to previous time-dependent searches, these analyses enable a feature to possibly find multiple flares from a single direction with an unbinned maximum-likelihood method. M87 is found to be the most significant time-dependent source of this catalog at the level of 1.7σ post-trial, and TXS 0506+056 is the only source for which two flares are reconstructed. The binomial test reports a cumulative time-dependent neutrino excess in the Northern Hemisphere at the level of 3.0σ associated with four sources: M87, TXS 0506+056, GB6 J1542+6129, and NGC 1068.
Published: 2021

161. All-flavor constraints on nonstandard neutrino interactions and generalized matter potential with three years of IceCube DeepCore data

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, AA, Amin, NM, An, R, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Ashida, Y, Axani, S, Bai, X, V., A Balagopal, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Bontempo, F, Borowka, J, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Browne, S, Burgman, A, Busse, RS, Campana, MA, Chen, C, Chirkin, D, Choi, K, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Erpenbeck, H, Evans, J, Evenson, PA, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, and Fürst, P
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Mathematical physics, Astronomical sciences, Particle and high energy physics
Abstract: We report constraints on nonstandard neutrino interactions (NSI) from the observation of atmospheric neutrinos with IceCube, limiting all individual coupling strengths from a single dataset. Furthermore, IceCube is the first experiment to constrain flavor-violating and nonuniversal couplings simultaneously. Hypothetical NSI are generically expected to arise due to the exchange of a new heavy mediator particle. Neutrinos propagating in matter scatter off fermions in the forward direction with negligible momentum transfer. Hence the study of the matter effect on neutrinos propagating in the Earth is sensitive to NSI independently of the energy scale of new physics. We present constraints on NSI obtained with an all-flavor event sample of atmospheric neutrinos based on three years of IceCube DeepCore data. The analysis uses neutrinos arriving from all directions, with reconstructed energies between 5.6 GeV and 100 GeV. We report constraints on the individual NSI coupling strengths considered singly, allowing for complex phases in the case of flavor-violating couplings. This demonstrates that IceCube is sensitive to the full NSI flavor structure at a level competitive with limits from the global analysis of all other experiments. In addition, we investigate a generalized matter potential, whose overall scale and flavor structure are also constrained.
Published: 2021

162. A Pilot Randomized Controlled Trial of Effect of Genioglossus Muscle Strengthening on Obstructive Sleep Apnea Outcomes.

Author: Maghsoudipour, Maryam, Nokes, Brandon, Bosompra, Naa-Oye, Jen, Rachel, Li, Yanru, Moore, Stacie, DeYoung, Pamela N, Fine, Janelle, Edwards, Bradley A, Gilbertson, Dillon, Owens, Robert, Morgan, Todd, and Malhotra, Atul
Subjects: adjunctive treatment, continuous positive airway pressure, genioglossus muscle, mandibular advancement splint, obstructive sleep apnea, Sleep Research, Lung, Clinical Trials and Supportive Activities, Clinical Research, Clinical Sciences
Abstract: The genioglossus is a major upper airway dilator muscle. Our goal was to assess the efficacy of upper airway muscle training on Obstructive Sleep Apnea (OSA) as an adjunct treatment. Sixty-eight participants with OSA (AHI > 10/h) were recruited from our clinic. They fall into the following categories: (a) Treated with Automatic Positive Airway Pressure (APAP), (n = 21), (b) Previously failed APAP therapy (Untreated), (n = 25), (c) Treated with Mandibular Advancement Splint (MAS), (n = 22). All subjects were given a custom-made tongue strengthening device. We conducted a prospective, randomized, controlled study examining the effect of upper airway muscle training. In each subgroup, subjects were randomized to muscle training (volitional protrusion against resistance) or sham group (negligible resistance), with a 1:1 ratio over 3 months of treatment. In the baseline and the final visit, subjects completed home sleep apnea testing, Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), SF-36 (36-Item Short Form Survey), and Psychomotor Vigilance Test (PVT). Intervention (muscle training) did not affect the AHI (Apnea-Hypopnea Index), (p-values > 0.05). Based on PSQI, ESS, SF-36 scores, and PVT parameters, the changes between the intervention and sham groups were not significant, and the changes were not associated with the type of treatment (p-value > 0.05). The effectiveness of upper airway muscle training exercise as an adjunct treatment requires further study.
Published: 2021

163. Statistical uncertainty quantification to augment clinical decision support: a first implementation in sleep medicine.

Author: Kang, Dae Y, DeYoung, Pamela N, Tantiongloc, Justin, Coleman, Todd P, and Owens, Robert L
Subjects: Bioengineering, Sleep Research
Abstract: Machine learning has the potential to change the practice of medicine, particularly in areas that require pattern recognition (e.g. radiology). Although automated classification is unlikely to be perfect, few modern machine learning tools have the ability to assess their own classification confidence to recognize uncertainty that might need human review. Using automated single-channel sleep staging as a first implementation, we demonstrated that uncertainty information (as quantified using Shannon entropy) can be utilized in a "human in the loop" methodology to promote targeted review of uncertain sleep stage classifications on an epoch-by-epoch basis. Across 20 sleep studies, this feedback methodology proved capable of improving scoring agreement with the gold standard over automated scoring alone (average improvement in Cohen's Kappa of 0.28), in a fraction of the scoring time compared to full manual review (60% reduction). In summary, our uncertainty-based clinician-in-the-loop framework promotes the improvement of medical classification accuracy/confidence in a cost-effective and economically resourceful manner.
Published: 2021

164. LeptonInjector and LeptonWeighter: A neutrino event generator and weighter for neutrino observatories

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, AA, Amin, NM, An, R, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Axani, S, Bai, X, Balagopal, A, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Busse, RS, Campana, MA, Chen, C, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evans, J, Evenson, PA, Fahey, S, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, Fürst, P, Gaisser, TK, and Gallagher, J
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Information and Computing Sciences, Applied Computing, Physical Sciences, Neutrino generator, Event generator, Neutrino interaction, Neutrino simulation, Weighting, physics.comp-ph, hep-ex, hep-ph, Mathematical Sciences, Nuclear & Particles Physics, Information and computing sciences, Mathematical sciences, Physical sciences
Abstract: We present a high-energy neutrino event generator, called LeptonInjector, alongside an event weighter, called LeptonWeighter. Both are designed for large-volume Cherenkov neutrino telescopes such as IceCube. The neutrino event generator allows for quick and flexible simulation of neutrino events within and around the detector volume, and implements the leading Standard Model neutrino interaction processes relevant for neutrino observatories: neutrino-nucleon deep-inelastic scattering and neutrino-electron annihilation. In this paper, we discuss the event generation algorithm, the weighting algorithm, and the main functions of the publicly available code, with examples. Program summary: Program Titles: LeptonInjector and LeptonWeighter CPC Library link to program files: https://doi.org/10.17632/662gkpjfd9.1 Developer's repository links: https://github.com/icecube/LeptonInjector and https://github.com/icecube/LeptonWeighter Licensing provisions: GNU Lesser General Public License, version 3. Programming Language: C++11 External Routines: • Boost • HDF5 • nuflux (https://github.com/icecube/nuflux) • nuSQuIDS (https://github.com/arguelles/nuSQuIDS) • Photospline (https://github.com/icecube/photospline) • SuiteSparse (https://github.com/DrTimothyAldenDavis/SuiteSparse) Nature of problem: LeptonInjector: Generate neutrino interaction events of all possible topologies and energies throughout and around a detector volume. LeptonWeighter: Reweight Monte Carlo events, generated by a set of LeptonInjector Generators, to any desired physical neutrino flux or cross section. Solution method: LeptonInjector: Projected ranges of generated leptons and the extent of the detector, in terms of column depth, are used to inject events in and around the detector volume. Event kinematics follow distributions provided in cross section files. LeptonWeighter: Event generation probabilities are calculated for each Generator, which are then combined into a generation weight and used to calculate an overall event weight.
Published: 2021

165. Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology

Author: Tiego, Jeggan, Martin, Elizabeth A., DeYoung, Colin G., Hagan, Kelsey, Cooper, Samuel E., Pasion, Rita, Satchell, Liam, Shackman, Alexander J., Bellgrove, Mark A., and Fornito, Alex
Published: 2023
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166. Within-pair factors might explain the inconsistent effects of animacy on paired-associates recall

Author: Serra, Michael J. and DeYoung, Carlee M.
Published: 2023
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167. Erratum: 'Limits on Neutrino Emission from GRB 221009A from MeV to PeV Using the IceCube Neutrino Observatory' (2023, ApJL, 946, L26)

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, N. Aggarwal, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, C. Dappen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Astrophysics, QB460-466
Published: 2024
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168. First all-flavor search for transient neutrino emission using 3-years of IceCube DeepCore data

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguyên, L. V., Nielsen, M. L., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Since the discovery of a flux of high-energy astrophysical neutrinos, searches for their origins have focused primarily at TeV-PeV energies. Compared to sub-TeV searches, high-energy searches benefit from an increase in the neutrino cross section, improved angular resolution on the neutrino direction, and a reduced background from atmospheric neutrinos and muons. However, the focus on high energy does not preclude the existence of sub-TeV neutrino emission where IceCube retains sensitivity. Here we present the first all-flavor search from IceCube for transient emission of low-energy neutrinos, focusing on the energy region of 5.6-100 GeV using three years of data obtained with the IceCube-DeepCore detector. We find no evidence of transient neutrino emission in the data, thus leading to a constraint on the volumetric rate of astrophysical transient sources in the range of $\sim 705-2301\, \text{Gpc}^{-3}\, \text{yr}^{-1}$ for sources following a subphotospheric energy spectrum with a mean energy of 100 GeV and a bolometric energy of $10^{52}$ erg., Comment: 16 pages, 10 figures. Update from previous arXiv version reflects a change to the title, minor text edits, and additional description of the statistical derivation of the results, which were all part of the JCAP review process
Published: 2020
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169. Detection of astrophysical tau neutrino candidates in IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: High-energy tau neutrinos are rarely produced in atmospheric cosmic-ray showers or at cosmic particle accelerators, but are expected to emerge during neutrino propagation over cosmic distances due to flavor mixing. When high energy tau neutrinos interact inside the IceCube detector, two spatially separated energy depositions may be resolved, the first from the charged current interaction and the second from the tau lepton decay. We report a novel analysis of 7.5 years of IceCube data that identifies two candidate tau neutrinos among the 60 ``High-Energy Starting Events'' (HESE) collected during that period. The HESE sample offers high purity, all-sky sensitivity, and distinct observational signatures for each neutrino flavor, enabling a new measurement of the flavor composition. The measured astrophysical neutrino flavor composition is consistent with expectations, and an astrophysical tau neutrino flux is indicated at 2.8$\sigma$ significance., Comment: This article is supported by a long-form paper that discusses the high-energy starting event selection titled: "The IceCube high-energy starting event sample: Description and flux characterization with 7.5 years of data."
Published: 2020
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170. Measurement of the high-energy all-flavor neutrino-nucleon cross section with IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: The flux of high-energy neutrinos passing through the Earth is attenuated due to their interactions with matter. The interaction rate is modulated by the neutrino interaction cross section and affects the flux arriving at the IceCube Neutrino Observatory, a cubic-kilometer neutrino detector embedded in the Antarctic ice sheet. We present a measurement of the neutrino cross section between 60 TeV and 10 PeV using the high-energy starting events (HESE) sample from IceCube with 7.5 years of data. The result is binned in neutrino energy and obtained using both Bayesian and frequentist statistics. We find it compatible with predictions from the Standard Model. Flavor information is explicitly included through updated morphology classifiers, proxies for the the three neutrino flavors. This is the first such measurement to use the three morphologies as observables and the first to account for neutrinos from tau decay., Comment: 10 pages, 7 figures, 2 tables. This article is supported by a long-form paper that discusses in high-energy starting event selection titled: "The IceCube high-energy starting event sample: Description and flux characterization with 7.5 years of data"
Published: 2020
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171. The IceCube high-energy starting event sample: Description and flux characterization with 7.5 years of data

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves Jr., A. A., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katori, T., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mandalia, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., and Zhang, Z.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: The IceCube Neutrino Observatory has established the existence of a high-energy all-sky neutrino flux of astrophysical origin. This discovery was made using events interacting within a fiducial region of the detector surrounded by an active veto and with reconstructed energy above 60 TeV, commonly known as the high-energy starting event sample, or HESE. We revisit the analysis of the HESE sample with an additional 4.5 years of data, newer glacial ice models, and improved systematics treatment. This paper describes the sample in detail, reports on the latest astrophysical neutrino flux measurements, and presents a source search for astrophysical neutrinos. We give the compatibility of these observations with specific isotropic flux models proposed in the literature as well as generic power-law-like scenarios. Assuming $\nu_e:\nu_\mu:\nu_\tau=1:1:1$, and an equal flux of neutrinos and antineutrinos, we find that the astrophysical neutrino spectrum is compatible with an unbroken power law, with a preferred spectral index of ${2.87}^{+0.20}_{-0.19}$ for the $68.3\%$ confidence interval., Comment: 57 pages, 33 figures, 14 tables, additionally this work is accompanied by papers titled "Measurement of Astrophysical Tau Neutrinos in IceCube's High-Energy Starting Events" and "Measurement of the high-energy all-flavor neutrino-nucleon cross section with IceCube"
Published: 2020
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172. A novel approach for extracting model-independent nuclear level densities far from stability

Author: Mücher, D., Spyrou, A., Wiedeking, M., Guttormsen, M., Larsen, A. C., Zeiser, F., Harris, C., Richard, A. L., Smith, M. K., Görgen, A., Liddick, S. N., Siem, S., Berg, H., Clark, J. A., DeYoung, P. A., Dombos, A. C., Greaves, B., Hicks, L., Kelmar, R., Lyons, S., Owens-Fryar, J., Palmisano, A., Santiago-Gonzalez, D., Savard, G., and von Seeger, W. W.
Subjects: Nuclear Experiment
Abstract: The level density of quantum states in statistical mesoscopic systems is a critical input for various fields of physics, including nuclear physics, nuclear astrophysics, atomic physics and their applications. In atomic nuclei, the level density is a fundamental measure of their complex structure at relatively high energies. Here we present the first model-independent measurement of the absolute partial nuclear level density for a short-lived unstable nucleus. For this purpose, we introduce the ``Shape method'' to extract the shape of the $\gamma$-ray strength function. Combining the Shape method with the existing $\beta$-Oslo technique allows the extraction of the nuclear level density without the need for theoretical input. We benchmark the Shape method using results for the stable $^{76}$Ge nucleus, finding an excellent agreement to previous experimental results. We apply the Shape method to new experimental data on the short-lived $^{88}$Kr nucleus. Our method opens the door for measurements of the nuclear level density and $\gamma$-ray strength function far away from stability, a pivotal input required to understand the role of exotic nuclei in forming the cosmos.
Published: 2020

173. Nested Session Types

Author: Das, Ankush, DeYoung, Henry, Mordido, Andreia, and Pfenning, Frank
Subjects: Computer Science - Programming Languages, Computer Science - Logic in Computer Science
Abstract: Session types statically describe communication protocols between concurrent message-passing processes. Unfortunately, parametric polymorphism even in its restricted prenex form is not fully understood in the context of session types. In this paper, we present the metatheory of session types extended with prenex polymorphism and, as a result, nested recursive datatypes. Remarkably, we prove that type equality is decidable by exhibiting a reduction to trace equivalence of deterministic first-order grammars. Recognizing the high theoretical complexity of the latter, we also propose a novel type equality algorithm and prove its soundness. We observe that the algorithm is surprisingly efficient and, despite its incompleteness, sufficient for all our examples. We have implemented our ideas by extending the Rast programming language with nested session types. We conclude with several examples illustrating the expressivity of our enhanced type system., Comment: Technical Report
Published: 2020

174. Understanding Clinical Trial Reports: Extracting Medical Entities and Their Relations

Author: Nye, Benjamin E., DeYoung, Jay, Lehman, Eric, Nenkova, Ani, Marshall, Iain J., and Wallace, Byron C.
Subjects: Computer Science - Computation and Language
Abstract: The best evidence concerning comparative treatment effectiveness comes from clinical trials, the results of which are reported in unstructured articles. Medical experts must manually extract information from articles to inform decision-making, which is time-consuming and expensive. Here we consider the end-to-end task of both (a) extracting treatments and outcomes from full-text articles describing clinical trials (entity identification) and, (b) inferring the reported results for the former with respect to the latter (relation extraction). We introduce new data for this task, and evaluate models that have recently achieved state-of-the-art results on similar tasks in Natural Language Processing. We then propose a new method motivated by how trial results are typically presented that outperforms these purely data-driven baselines. Finally, we run a fielded evaluation of the model with a non-profit seeking to identify existing drugs that might be re-purposed for cancer, showing the potential utility of end-to-end evidence extraction systems.
Published: 2020

175. Multimessenger Gamma-Ray and Neutrino Coincidence Alerts using HAWC and IceCube sub-threshold Data

Author: Solares, H. A. Ayala, Coutu, S., DeLaunay, J. J., Fox, D. B., Grégoire, T., Keivani, A., Krauß, F., Mostafá, M., Murase, K., Turley, C. F., Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Belmont-Moreno, E., Brisbois, C., Caballero-Mora, K. S., Carramiñana, A., Casanova, S., Cotti, U., De la Fuente, E., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Durocher, M., Díaz-Vélez, J. C., Espinoza, C., Fan, K. L., Fleischhack, H., Fraija, N., Galván-Gámez, A., Garcia, D., García-González, J. A., Garfias, F., González, M. M., Goodman, J. A., Harding, J. P., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Huntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Moreno, E., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Peisker, A., Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Salazar, H., Greus, F. Salesa, Sandoval, A., Smith, A. J., Springer, R. W., Tollefson, K., Torres, I., Torres-Escobedo, R., Ureña-Mena, F., Villaseñor, L., Weisgarber, T., Willox, E., Zepeda, A., Zhou, H., de León, C., Aartsen, M. G., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Dujmovic, H., Dunkman, M., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Fienberg, A., Filimonov, K., Finley, C., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wills, L., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., Zhang, Z., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The High Altitude Water Cherenkov (HAWC) and IceCube observatories, through the Astrophysical Multimessenger Observatory Network (AMON) framework, have developed a multimessenger joint search for extragalactic astrophysical sources. This analysis looks for sources that emit both cosmic neutrinos and gamma rays that are produced in photo-hadronic or hadronic interactions. The AMON system is running continuously, receiving sub-threshold data (i.e. data that is not suited on its own to do astrophysical searches) from HAWC and IceCube, and combining them in real-time. We present here the analysis algorithm, as well as results from archival data collected between June 2015 and August 2018, with a total live-time of 3.0 years. During this period we found two coincident events that have a false alarm rate (FAR) of $<1$ coincidence per year, consistent with the background expectations. The real-time implementation of the analysis in the AMON system began on November 20th, 2019, and issues alerts to the community through the Gamma-ray Coordinates Network with a FAR threshold of $<4$ coincidences per year., Comment: 14 pages, 5 figures, 3 tables
Published: 2020
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176. IceCube-Gen2: The Window to the Extreme Universe

Author: Collaboration, The IceCube-Gen2, Aartsen, M. G., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Allison, P., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Arlen, T. C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Bartos, I., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Bohmer, M., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Burley, R. T., Buscher, J., Busse, R. S., Bustamante, M., Campana, M. A., Carnie-Bronca, E. G., Carver, T., Chen, C., Chen, P., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., Deaconu, C., De Clercq, C., DeLaunay, J. J., De Kockere, S., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J. J., Evenson, P. A., Fahey, S., Farrag, K., Fazely, A. R., Felde, J., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia-Fernandez, D., Garrappa, S., Gartner, A., Gerhardt, L., Gernhaeuser, R., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, J. C., Hanson, K., Hardin, J., Haugen, J., Haungs, A., Hauser, S., Hebecker, D., Heinen, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, B., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Holzapfel, K., Hoshina, K., Huang, F., Huber, M., Huber, T., Huege, T., Hughes, K., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kalekin, O., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katori, T., Katz, U., Kauer, M., Keivani, A., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Kittler, T., Kleifges, M., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krauss, C. B., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Gualda, C. Lagunas, Lahmann, R., Lanfranchi, J. L., Larson, M. J., Latif, U., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., LoSecco, J., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mandalia, S., Mariş, I. C., Marka, S., Marka, Z., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Meyers, Z. S., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Naab, R., Nagai, R., Nam, J., Naumann, U., Necker, J., Neer, G., Nelles, A., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Oberla, E., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pan, Y., Pandya, H., Pankova, D. V., Papp, L., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Petersen, T. C., Philippen, S., Pieloth, D., Pieper, S., Pinfold, J. L., Pizzuto, A., Plaisier, I., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Riegel, M., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Sandstrom, P., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shaevitz, M. H., Sharma, A., Shefali, S., Silva, M., Smith, D., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Söldner-Rembold, S., Song, M., Southall, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Taketa, A., Tanaka, H. K. M., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Torres, J., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Veberic, D., Verpoest, S., Vieregg, A., Vraeghe, M., Walck, C., Watson, T. B., Weaver, C., Weindl, A., Weinstock, L., Weiss, M. J., Weldert, J., Welling, C., Wendt, C., Werthebach, J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissel, S. A., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wren, S., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., Zhang, Z., Zierke, S., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The observation of electromagnetic radiation from radio to $\gamma$-ray wavelengths has provided a wealth of information about the universe. However, at PeV (10$^{15}$ eV) energies and above, most of the universe is impenetrable to photons. New messengers, namely cosmic neutrinos, are needed to explore the most extreme environments of the universe where black holes, neutron stars, and stellar explosions transform gravitational energy into non-thermal cosmic rays. The discovery of cosmic neutrinos with IceCube has opened this new window on the universe. In this white paper, we present an overview of a next-generation instrument, IceCube-Gen2, which will sharpen our understanding of the processes and environments that govern the universe at the highest energies. IceCube-Gen2 is designed to: 1) Resolve the high-energy neutrino sky from TeV to EeV energies; 2) Investigate cosmic particle acceleration through multi-messenger observations; 3) Reveal the sources and propagation of the highest energy particles in the universe; 4) Probe fundamental physics with high-energy neutrinos. IceCube-Gen2 will increase the annual rate of observed cosmic neutrinos by a factor of ten compared to IceCube, and will be able to detect sources five times fainter than its predecessor. Furthermore, through the addition of a radio array, IceCube-Gen2 will extend the energy range by several orders of magnitude compared to IceCube. Construction will take 8 years and cost about \$350M. The goal is to have IceCube-Gen2 fully operational by 2033. IceCube-Gen2 will play an essential role in shaping the new era of multi-messenger astronomy, fundamentally advancing our knowledge of the high-energy universe. This challenging mission can be fully addressed only in concert with the new survey instruments across the electromagnetic spectrum and gravitational wave detectors which will be available in the coming years., Comment: 56 pages, 29 figures
Published: 2020
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177. Measurements of the Time-Dependent Cosmic-Ray Sun Shadow with Seven Years of IceCube Data -- Comparison with the Solar Cycle and Magnetic Field Models

Author: Aartsen, M. G., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Fichtner, H., Fienberg, A. T., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Kittler, T., Kleimann, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wills, L., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., Zhang, Z., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract: Observations of the time-dependent cosmic-ray Sun shadow have been proven as a valuable diagnostic for the assessment of solar magnetic field models. In this paper, seven years of IceCube data are compared to solar activity and solar magnetic field models. A quantitative comparison of solar magnetic field models with IceCube data on the event rate level is performed for the first time. Additionally, a first energy-dependent analysis is presented and compared to recent predictions. We use seven years of IceCube data for the Moon and the Sun and compare them to simulations on data rate level. The simulations are performed for the geometrical shadow hypothesis for the Moon and the Sun and for a cosmic-ray propagation model governed by the solar magnetic field for the case of the Sun. We find that a linearly decreasing relationship between Sun shadow strength and solar activity is preferred over a constant relationship at the 6.4sigma level. We test two commonly used models of the coronal magnetic field, both combined with a Parker spiral, by modeling cosmic-ray propagation in the solar magnetic field. Both models predict a weakening of the shadow in times of high solar activity as it is also visible in the data. We find tensions with the data on the order of $3\sigma$ for both models, assuming only statistical uncertainties. The magnetic field model CSSS fits the data slightly better than the PFSS model. This is generally consistent with what is found previously by the Tibet AS-gamma Experiment, a deviation of the data from the two models is, however, not significant at this point. Regarding the energy dependence of the Sun shadow, we find indications that the shadowing effect increases with energy during times of high solar activity, in agreement with theoretical predictions., Comment: 38 pages, 13 figures. Submitted
Published: 2020
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178. Searching for eV-scale sterile neutrinos with eight years of atmospheric neutrinos at the IceCube neutrino telescope

Author: Aartsen, M. G., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Fedynitch, A., Felde, J., Fienberg, A. T., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wills, L., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Zhang, Z., and Zöcklein, M.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: We report in detail on searches for eV-scale sterile neutrinos, in the context of a 3+1 model, using eight years of data from the IceCube neutrino telescope. By analyzing the reconstructed energies and zenith angles of 305,735 atmospheric $\nu_\mu$ and $\bar{\nu}_\mu$ events we construct confidence intervals in two analysis spaces: $\sin^2 (2\theta_{24})$ vs. $\Delta m^2_{41}$ under the conservative assumption $\theta_{34}=0$; and $\sin^2(2\theta_{24})$ vs. $\sin^2 (2\theta_{34})$ given sufficiently large $\Delta m^2_{41}$ that fast oscillation features are unresolvable. Detailed discussions of the event selection, systematic uncertainties, and fitting procedures are presented. No strong evidence for sterile neutrinos is found, and the best-fit likelihood is consistent with the no sterile neutrino hypothesis with a p-value of 8\% in the first analysis space and 19\% in the second., Comment: This long-form paper is a companion to the letter "An eV-scale sterile neutrino search using eight years of atmospheric muon neutrino data from the IceCube Neutrino Observatory". v2: update other experiments contours on results plot
Published: 2020
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179. An eV-scale sterile neutrino search using eight years of atmospheric muon neutrino data from the IceCube Neutrino Observatory

Author: Aartsen, M. G., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Fedynitch, A., Felde, J., Fienberg, A. T., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wills, L., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Zhang, Z., and Zöcklein, M.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: The results of a 3+1 sterile neutrino search using eight years of data from the IceCube Neutrino Observatory are presented. A total of 305,735 muon neutrino events are analyzed in reconstructed energy-zenith space to test for signatures of a matter-enhanced oscillation that would occur given a sterile neutrino state with a mass-squared differences between 0.01\,eV$^2$ and 100\,eV$^2$. The best-fit point is found to be at $\sin^2(2\theta_{24})=0.10$ and $\Delta m_{41}^2 = 4.5{\rm eV}^2$, which is consistent with the no sterile neutrino hypothesis with a p-value of 8.0\%., Comment: 11 pages, 5 figures. This letter is supported by the long-form paper "Searching for eV-scale sterile neutrinos with eight years of atmospheric neutrinos at the IceCube neutrino telescope," also appearing on arXiv. Digital data release available at: https://github.com/icecube/HE-Sterile-8year-data-release
Published: 2020
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180. Evidence Inference 2.0: More Data, Better Models

Author: DeYoung, Jay, Lehman, Eric, Nye, Ben, Marshall, Iain J., and Wallace, Byron C.
Subjects: Computer Science - Computation and Language
Abstract: How do we most effectively treat a disease or condition? Ideally, we could consult a database of evidence gleaned from clinical trials to answer such questions. Unfortunately, no such database exists; clinical trial results are instead disseminated primarily via lengthy natural language articles. Perusing all such articles would be prohibitively time-consuming for healthcare practitioners; they instead tend to depend on manually compiled systematic reviews of medical literature to inform care. NLP may speed this process up, and eventually facilitate immediate consult of published evidence. The Evidence Inference dataset was recently released to facilitate research toward this end. This task entails inferring the comparative performance of two treatments, with respect to a given outcome, from a particular article (describing a clinical trial) and identifying supporting evidence. For instance: Does this article report that chemotherapy performed better than surgery for five-year survival rates of operable cancers? In this paper, we collect additional annotations to expand the Evidence Inference dataset by 25\%, provide stronger baseline models, systematically inspect the errors that these make, and probe dataset quality. We also release an abstract only (as opposed to full-texts) version of the task for rapid model prototyping. The updated corpus, documentation, and code for new baselines and evaluations are available at http://evidence-inference.ebm-nlp.com/., Comment: Accepted as workshop paper into BioNLP Updated results from SciBERT to Biomed RoBERTa
Published: 2020

181. IceCube Search for Neutrinos Coincident with Compact Binary Mergers from LIGO-Virgo's First Gravitational-Wave Transient Catalog

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Bartos, I., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Corley, K. R., Correa, P., Countryman, S., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hauser, S., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Keivani, A., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczynska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Marka, S., Marka, Z., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Merz, J., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stössl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Veske, D., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Using the IceCube Neutrino Observatory, we search for high-energy neutrino emission coincident with compact binary mergers observed by the LIGO and Virgo gravitational wave (GW) detectors during their first and second observing runs. We present results from two searches targeting emission coincident with the sky localization of each gravitational wave event within a 1000 second time window centered around the reported merger time. One search uses a model-independent unbinned maximum likelihood analysis, which uses neutrino data from IceCube to search for point-like neutrino sources consistent with the sky localization of GW events. The other uses the Low-Latency Algorithm for Multi-messenger Astrophysics, which incorporates astrophysical priors through a Bayesian framework and includes LIGO-Virgo detector characteristics to determine the association between the GW source and the neutrinos. No significant neutrino coincidence is seen by either search during the first two observing runs of the LIGO-Virgo detectors. We set upper limits on the time-integrated neutrino emission within the 1000 second window for each of the 11 GW events. These limits range from 0.02-0.7 $\mathrm{GeV~cm^{-2}}$. We also set limits on the total isotropic equivalent energy, $E_{\mathrm{iso}}$, emitted in high-energy neutrinos by each GW event. These limits range from 1.7 $\times$ 10$^{51}$ - 1.8 $\times$ 10$^{55}$ erg. We conclude with an outlook for LIGO-Virgo observing run O3, during which both analyses are running in real time.
Published: 2020
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182. IceCube Search for High-Energy Neutrino Emission from TeV Pulsar Wind Nebulae

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Pulsar wind nebulae (PWNe) are the main gamma-ray emitters in the Galactic plane. They are diffuse nebulae that emit nonthermal radiation. Pulsar winds, relativistic magnetized outflows from the central star, shocked in the ambient medium produce a multiwavelength emission from the radio through gamma rays. Although the leptonic scenario is able to explain most PWNe emission, a hadronic contribution cannot be excluded. A possible hadronic contribution to the high-energy gamma-ray emission inevitably leads to the production of neutrinos. Using 9.5 yr of all-sky IceCube data, we report results from a stacking analysis to search for neutrino emission from 35 PWNe that are high-energy gamma-ray emitters. In the absence of any significant correlation, we set upper limits on the total neutrino emission from those PWNe and constraints on hadronic spectral components., Comment: 11 pages, 2 figures; matches the published version in ApJ
Published: 2020
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183. Combined search for neutrinos from dark matter self-annihilation in the Galactic Centre with ANTARES and IceCube

Author: ANTARES Collaboration, Albert, A., André, M., Anghinolfi, M., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Coyle, P., Creusot, A., Díaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Khayati, N. El, Enzenhöfer, A., Ettahiri, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Ruiz, R. Gracia, Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nuñez-Castiñeyra, A., O'Fearraigh, B., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poirè, C., Popa, V., Pradier, T., Randazzo, N., Reck, S., Riccobene, G., Sánchez-Losa, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Collaboration, IceCube, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stö\s{s}l, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the results of the first combined dark matter search targeting the Galactic Centre using the ANTARES and IceCube neutrino telescopes. For dark matter particles with masses from 50 to 1000 GeV, the sensitivities on the self-annihilation cross section set by ANTARES and IceCube are comparable, making this mass range particularly interesting for a joint analysis. Dark matter self-annihilation through the $\tau^+\tau^-$, $\mu^+\mu^-$, $b\bar{b}$ and $W^+W^-$ channels is considered for both the Navarro-Frenk-White and Burkert halo profiles. In the combination of 2,101.6 days of ANTARES data and 1,007 days of IceCube data, no excess over the expected background is observed. Limits on the thermally-averaged dark matter annihilation cross section $\langle\sigma_A\upsilon\rangle$ are set. These limits present an improvement of up to a factor of two in the studied dark matter mass range with respect to the individual limits published by both collaborations. When considering dark matter particles with a mass of 200 GeV annihilating through the $\tau^+\tau^-$ channel, the value obtained for the limit is $7.44 \times 10^{-24} \text{cm}^{3}\text{s}^{-1}$ for the Navarro-Frenk-White halo profile. For the purpose of this joint analysis, the model parameters and the likelihood are unified, providing a benchmark for forthcoming dark matter searches performed by neutrino telescopes.
Published: 2020
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184. Characteristics of the diffuse astrophysical electron and tau neutrino flux with six years of IceCube high energy cascade data

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Lesiak-Bzdak, M., Leszczyńska, A., Leuermann, M., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mari{ş}, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We report on the first measurement of the astrophysical neutrino flux using particle showers (cascades) in IceCube data from 2010 -- 2015. Assuming standard oscillations, the astrophysical neutrinos in this dedicated cascade sample are dominated ($\sim 90 \%$) by electron and tau flavors. The flux, observed in the sensitive energy range from $16\,\mathrm{TeV}$ to $2.6\,\mathrm{PeV}$, is consistent with a single power-law model as expected from Fermi-type acceleration of high energy particles at astrophysical sources. We find the flux spectral index to be $\gamma=2.53\pm0.07$ and a flux normalization for each neutrino flavor of $\phi_{astro} = 1.66^{+0.25}_{-0.27}$ at $E_{0} = 100\, \mathrm{TeV}$, in agreement with IceCube's complementary muon neutrino results and with all-neutrino flavor fit results. In the measured energy range we reject spectral indices $\gamma\leq2.28$ at $\ge3\sigma$ significance level. Due to high neutrino energy resolution and low atmospheric neutrino backgrounds, this analysis provides the most detailed characterization of the neutrino flux at energies below $\sim100\,{\rm{TeV}}$ compared to previous IceCube results. Results from fits assuming more complex neutrino flux models suggest a flux softening at high energies and a flux hardening at low energies (p-value $\ge 0.06$). The sizable and smooth flux measured below $\sim 100\,{\rm{TeV}}$ remains a puzzle. In order to not violate the isotropic diffuse gamma-ray background as measured by the Fermi-LAT, it suggests the existence of astrophysical neutrino sources characterized by dense environments which are opaque to gamma-rays., Comment: 4 figures, 4 tables, includes supplementary material
Published: 2020
Full Text: View/download PDF

185. ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky

Author: ANTARES Collaboration, Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Chau, T. N., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Díaz, A. F., de Wasseige, G., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Ruiz, R. Gracia, Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maggi, G., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moser, M., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Nielsen, C., Nuñez-Castiñeyra, A., O'Fearraigh, B., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Poirè, C., Popa, V., Pradier, T., Quinn, L., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Strandberg, B., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zegarelli, A., Zornoza, J. D., Zúñiga, J., Collaboration, IceCube, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Leuermann, M., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: A search for point-like and extended sources of cosmic neutrinos using data collected by the ANTARES and IceCube neutrino telescopes is presented. The data set consists of all the track-like and shower-like events pointing in the direction of the Southern Sky included in the nine-year ANTARES point-source analysis, combined with the through-going track-like events used in the seven-year IceCube point-source search. The advantageous field of view of ANTARES and the large size of IceCube are exploited to improve the sensitivity in the Southern Sky by a factor $\sim$2 compared to both individual analyses. In this work, the Southern Sky is scanned for possible excesses of spatial clustering, and the positions of preselected candidate sources are investigated. In addition, special focus is given to the region around the Galactic Centre, whereby a dedicated search at the location of SgrA* is performed, and to the location of the supernova remnant RXJ 1713.7-3946. No significant evidence for cosmic neutrino sources is found and upper limits on the flux from the various searches are presented.
Published: 2020
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186. A search for IceCube events in the direction of ANITA neutrino candidates

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Leuermann, M., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: During the first three flights of the Antarctic Impulsive Transient Antenna (ANITA) experiment, the collaboration detected several neutrino candidates. Two of these candidate events were consistent with an ultra-high-energy up-going air shower and compatible with a tau neutrino interpretation. A third neutrino candidate event was detected in a search for Askaryan radiation in the Antarctic ice, although it is also consistent with the background expectation. The inferred emergence angle of the first two events is in tension with IceCube and ANITA limits on isotropic cosmogenic neutrino fluxes. Here, we test the hypothesis that these events are astrophysical in origin, possibly caused by a point source in the reconstructed direction. Given that any ultra-high-energy tau neutrino flux traversing the Earth should be accompanied by a secondary flux in the TeV-PeV range, we search for these secondary counterparts in seven years of IceCube data using three complementary approaches. In the absence of any significant detection, we set upper limits on the neutrino flux from potential point sources. We compare these limits to ANITA's sensitivity in the same direction and show that an astrophysical explanation of these anomalous events under standard model assumptions is severely constrained regardless of source spectrum.
Published: 2020
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187. Physical activity and stress among college students at a large US university during the COVID‐19 pandemic

Author: Wendy DeYoung, Becca Schulte, and Kaigang Li
Subjects: college students, COVID‐19 pandemic, perceived stress, physical activity, sitting time, trends, Public aspects of medicine, RA1-1270
Abstract: Abstract Background As the onset of the COVID‐19 pandemic and subsequent lockdown in March 2020, reports indicate reduced physical activity (PA), increased sitting time (ST), and higher stress in various groups. It remains uncertain if these patterns persist in college students. This study aimed to discover trends in vigorous PA (VPA), moderate PA (MPA), light PA (LPA), ST, and stress among college students from 2020 to early 2022, spanning 2 years. Methods Using a repeated cross‐sectional design, this study involved three online surveys in Summer and Fall 2020, and Winter 2021, respectively. Participants recalled pre‐COVID‐19 information in the first two periods and reported current information during COVID in all three periods, outlining four time points: Before‐COVID and During‐COVID times 1, 2, and 3. Results This study included 2163 students from a large Western university. All types of PA decreased from the start of the pandemic to late 2021; however, increases toward pre‐pandemic levels in MPA and LPA were found in early 2022. Also, activity shifted from VPA to MPA and LPA. Although ST and perceived stress (PS) surged in the pandemic's first year, they began decreasing toward pre‐COVID levels in early 2022. Conclusion The study indicates a decline in PA during the peak of the pandemic, followed by a recent return to almost pre‐COVID levels. Additionally, elevated ST and PS in early pandemic have reduced by the third year. As society begins to live with a new COVID‐normal, there must be adaptations to maintain PA and promote mental well‐being.
Published: 2023
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188. Brain Tumors: Development, Drug Resistance, and Sensitization – An Epigenetic Approach

Author: Sibaji Sarkar, Tara Deyoung, Hope Ressler, and Whitney Chandler
Subjects: pediatric and adult brain tumours, development of tumours, epigenetic switch, histone modification, dna methylation, combination therapy, drug resistance, sensitization, Genetics, QH426-470
Abstract: In this article, we describe contrasting developmental aspects of paediatric and adult brain tumours. We hypothesize that the formation of cancer progenitor cells, for both paediatric and adult, could be due to epigenetic events. However, the progression of adult brain tumours selectively involves more mutations compared to paediatric tumours. We further discuss epigenetic switches, comprising both histone modifications and DNA methylation, and how they can differentially regulate transcription and expression of oncogenes and tumour suppressor genes. Next, we summarize the currently available therapies for both types of brain tumours, explaining the merits and failures leading to drug resistance. We analyse different mechanisms of drug resistance and the role of epigenetics in this process. We then provide a rationale for combination therapy, which includes epigenetic drugs. In the end, we postulate a concept which describes how a combination therapy could be initiated. The timing, doses, and order of individual drug regimens will depend on the individual case. This type of combination therapy will be part of a personalized medicine which will differ from patient to patient.
Published: 2023
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189. Measurement of the high-energy all-flavor neutrino-nucleon cross section with IceCube

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, AA, Amin, NM, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Axani, S, Bai, X, V., A Balagopal, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Busse, RS, Campana, MA, Chen, C, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evans, J, Evenson, PA, Fahey, S, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, Fürst, P, Gaisser, TK, Gallagher, J, and Ganster, E
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Mathematical physics, Astronomical sciences, Particle and high energy physics
Abstract: The flux of high-energy neutrinos passing through the Earth is attenuated due to their interactions with matter. The interaction rate is determined by the neutrino interaction cross section and affects the flux arriving at the IceCube Neutrino Observatory, a cubic-kilometer neutrino detector embedded in the Antarctic ice sheet. We present a measurement of the neutrino cross section between 60 TeV and 10 PeV using the high-energy starting event (HESE) sample from IceCube with 7.5 years of data. The result is binned in neutrino energy and obtained using both Bayesian and frequentist statistics. We find it compatible with predictions from the Standard Model. While the cross section is expected to be flavor independent above 1 TeV, additional constraints on the measurement are included through updated experimental particle identification (PID) classifiers, proxies for the three neutrino flavors. This is the first such measurement to use a ternary PID observable and the first to account for neutrinos from tau decay.
Published: 2021

190. IceCube high-energy starting event sample: Description and flux characterization with 7.5 years of data

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, AA, Amin, NM, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Axani, S, Bai, X, V., A Balagopal, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Busse, RS, Campana, MA, Chen, C, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evans, J, Evenson, PA, Fahey, S, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, Fürst, P, Gaisser, TK, Gallagher, J, and Ganster, E
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Mathematical physics, Astronomical sciences, Particle and high energy physics
Abstract: The IceCube Neutrino Observatory has established the existence of a high-energy all-sky neutrino flux of astrophysical origin. This discovery was made using events interacting within a fiducial region of the detector surrounded by an active veto and with reconstructed energy above 60 TeV, commonly known as the high-energy starting event sample (HESE). We revisit the analysis of the HESE sample with an additional 4.5 years of data, newer glacial ice models, and improved systematics treatment. This paper describes the sample in detail, reports on the latest astrophysical neutrino flux measurements, and presents a source search for astrophysical neutrinos. We give the compatibility of these observations with specific isotropic flux models proposed in the literature as well as generic power-law-like scenarios. Assuming νe:νμ:ντ=1:1:1, and an equal flux of neutrinos and antineutrinos, we find that the astrophysical neutrino spectrum is compatible with an unbroken power law, with a preferred spectral index of 2.87-0.19+0.20 for the 68% confidence interval.
Published: 2021

191. IceCube-Gen2: the window to the extreme Universe

Author: Aartsen, MG, Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Allison, P, Amin, NM, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Arlen, TC, Auffenberg, J, Axani, S, Bagherpour, H, Bai, X, Balagopal, A, Barbano, A, Bartos, I, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Bohm, C, Bohmer, M, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Burley, RT, Buscher, J, Busse, RS, Bustamante, M, Campana, MA, Carnie-Bronca, EG, Carver, T, Chen, C, Chen, P, Cheung, E, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Connolly, A, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, Deaconu, C, De Clercq, C, DeLaunay, JJ, De Kockere, S, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evans, JJ, and Evenson, PA
Subjects: neutrino astronomy, high-energy astrophysics, neutrino telescopes, astro-ph.HE, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics
Abstract: The observation of electromagnetic radiation from radio to γ-ray wavelengths has provided a wealth of information about the Universe. However, at PeV (1015 eV) energies and above, most of the Universe is impenetrable to photons. New messengers, namely cosmic neutrinos, are needed to explore the most extreme environments of the Universe where black holes, neutron stars, and stellar explosions transform gravitational energy into non-thermal cosmic rays. These energetic particles havemillions of times higher energies than those produced in the most powerful particle accelerators on Earth. As neutrinos can escape from regions otherwise opaque to radiation, they allow an unique view deep into exploding stars and the vicinity of the event horizons of black holes. The discovery of cosmic neutrinos with IceCube has opened this new window on the Universe. IceCube has been successful in finding first evidence for cosmic particle acceleration in the jet of an active galactic nucleus. Yet, ultimately, its sensitivity is too limited to detect even the brightest neutrino sources with high significance, or to detect populations of less luminous sources. In thiswhite paper, we present an overview of a next-generation instrument, IceCube-Gen2, which will sharpen our understanding of the processes and environments that govern the Universe at the highest energies. IceCube-Gen2 is designed to: (a) Resolve the high-energy neutrino sky from TeV to EeV energies (b) Investigate cosmic particle acceleration through multi-messenger observations (c) Reveal the sources and propagation of the highest energy particles in the Universe (d) Probe fundamental physics with high-energy neutrinos IceCube-Gen2 will enhance the existing IceCube detector at the South Pole. It will increase the annual rate of observed cosmic neutrinos by a factor of ten compared to IceCube, and will be able to detect sources five times fainter than its predecessor. Furthermore, through the addition of a radio array, IceCube- Gen2 will extend the energy range by several orders of magnitude compared to IceCube. Construction will take 8 years and cost about $350M. The goal is to have IceCube-Gen2 fully operational by 2033. IceCube-Gen2 will play an essential role in shaping the new era of multimessenger astronomy, fundamentally advancing our knowledge of the highenergy Universe. This challenging mission can be fully addressed only through the combination of the information from the neutrino, electromagnetic, and gravitational wave emission of high-energy sources, in concert with the new survey instruments across the electromagnetic spectrum and gravitational wave detectors which will be available in the coming years.
Published: 2021

192. Searches for neutrinos from cosmic-ray interactions in the Sun using seven years of IceCube data

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Haungs, A., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Leuermann, M., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merino, G., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Porcelli, A., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Zöcklein, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Cosmic-ray interactions with the solar atmosphere are expected to produce particle showers which in turn produce neutrinos from weak decays of mesons. These solar atmospheric neutrinos (SA$\nu$s) have never been observed experimentally. A detection would be an important step in understanding cosmic-ray propagation in the inner solar system and the dynamics of solar magnetic fields. SA$\nu$s also represent an irreducible background to solar dark matter searches and a detection would allow precise characterization of this background. Here, we present the first experimental search based on seven years of data collected from May 2010 to May 2017 in the austral winter with the IceCube Neutrino Observatory. An unbinned likelihood analysis is performed for events reconstructed within 5 degrees of the center of the Sun. No evidence for a SA$\nu$ flux is observed. After inclusion of systematic uncertainties, we set a 90\% upper limit of $1.02^{+0.20}_{-0.18}\cdot10^{-13}$~$\mathrm{GeV^{-1}cm^{-2}s^{-1}}$ at 1 TeV., Comment: 25 pages, 8 figures
Published: 2019
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193. Search for GeV neutrino emission during intense gamma-ray solar flares with the IceCube Neutrino Observatory

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, AA, Amin, NM, An, R, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Axani, S, Bai, X, V., A Balagopal, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Busse, RS, Campana, MA, Chen, C, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Vélez, JC Díaz, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evans, J, Evenson, PA, Fahey, S, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, Fürst, P, Gaisser, TK, and Gallagher, J
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Astronomical Sciences, Physical Sciences, astro-ph.HE, astro-ph.SR, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Mathematical physics, Astronomical sciences, Particle and high energy physics
Abstract: Solar flares convert magnetic energy into thermal and nonthermal plasma energy, the latter implying particle acceleration of charged particles such as protons. Protons are injected out of the coronal acceleration region and can interact with dense plasma in the lower solar atmosphere, producing mesons that subsequently decay into gamma rays and neutrinos at O(MeV-GeV) energies. We present the results of the first search for GeV neutrinos emitted during solar flares carried out with the IceCube Neutrino Observatory. While the experiment was originally designed to detect neutrinos with energies between 10 GeV and a few PeV, a new approach allowing for a O(GeV) energy threshold will be presented. The resulting limits allow us to constrain some of the theoretical estimates of the expected neutrino flux.
Published: 2021

194. Improvements in sleep-disordered breathing during acclimatization to 3800 m and the impact on cognitive function.

Author: Frost, Shyleen, E Orr, Jeremy, Oeung, Britney, Puvvula, Nikhil, Pham, Kathy, Brena, Rebbecca, DeYoung, Pamela, Jain, Sonia, Sun, Shelly, Malhotra, Atul, and Heinrich, Erica C
Subjects: cognition, high altitude, sleep, sleep-disordered breathing, Physiology, Clinical Sciences, Medical Physiology
Abstract: Sojourners to high altitude often experience poor sleep quality due to sleep-disordered breathing. Additionally, multiple aspects of cognitive function are impaired at high altitude. However, the impact of acclimatization on sleep-disordered breathing and whether poor sleep is a major contributor to cognitive impairments at high altitude remains uncertain. We conducted nocturnal actigraphy and polygraphy, as well as daytime cognitive function tests, in 15 participants (33% women) at sea level and over 3 days of partial acclimatization to high altitude (3800 m). Our goal was to determine if sleep-disordered breathing improved over time and if sleep-disordered breathing was associated with cognitive function. The apnea-hypopnea index and oxygen desaturation index increased on night 1 (adj. p = 0.026 and adj. p = 0.026, respectively), but both improved over the subsequent 2 nights. These measures were matched by poorer self-reported sleep quality on the Stanford Sleepiness Scale and PROMIS questionnaires following 1 night at high altitude (adj. p = 0.027 and adj. p = 0.022, respectively). The reaction time on the psychomotor vigilance task was slower at high altitude and did not improve (SL: 199 ± 27, ALT1: 224 ± 33, ALT2: 216 ± 41, ALT3: 212 ± 27 ms). The reaction times on the balloon analog risk task decreased at high altitude (SL: 474 ± 235, ALT1: 375 ± 159, ALT2: 291 ± 102, ALT3: 267 ± 90 ms), perhaps indicating increased risk-taking behavior. Finally, multiple cognitive function measures were associated with sleep-disordered breathing and measures of subjective sleep quality, rather than low daytime arterial oxygen saturation. These data indicate that sleep-disordered breathing at moderately high altitude improves with partial acclimatization and that some aspects of cognitive performance in unacclimatized sojourners may be impacted by poor sleep rather than hypoxemia alone.
Published: 2021

195. A search for time-dependent astrophysical neutrino emission with icecube data from 2012 to 2017

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, JA, Amin, NM, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Axani, S, Bai, X, Balagopal V, A, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, KH, Becker Tjus, J, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Busse, RS, Campana, MA, Chen, C, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evans, J, Evenson, PA, Fahey, S, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, Fürst, P, Gaisser, TK, Gallagher, J, and Ganster, E
Subjects: Particle astrophysics, High-energy astrophysics, Cosmic ray sources, astro-ph.HE, Astronomy & Astrophysics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural)
Abstract: High-energy neutrinos are unique messengers of the high-energy universe, tracing the processes of cosmic ray acceleration. This paper presents analyses focusing on time-dependent neutrino point-source searches. A scan of the whole sky, making no prior assumption about source candidates, is performed, looking for a space and time clustering of high-energy neutrinos in data collected by the IceCube Neutrino Observatory between 2012 and 2017. No statistically significant evidence for a time-dependent neutrino signal is found with this search during this period, as all results are consistent with the background expectation. Within this study period, the blazar 3C 279, showed strong variability, inducing a very prominent gamma-ray flare observed in 2015 June. This event motivated a dedicated study of the blazar, which consists of searching for a time-dependent neutrino signal correlated with the gamma-ray emission. No evidence for a time-dependent signal is found. Hence, an upper limit on the neutrino fluence is derived, allowing us to constrain a hadronic emission model.
Published: 2021

196. Follow-up of Astrophysical Transients in Real Time with the IceCube Neutrino Observatory

Author: Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Alves, AA, Amin, NM, An, R, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Argüelles, C, Axani, S, Bai, X, Balagopal V., A, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, KH, Tjus, JB, Bellenghi, C, Benzvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Böser, S, Botner, O, Böttcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Busse, RS, Campana, MA, Chen, C, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, Delaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, De Vries, KD, De Wasseige, G, De With, M, Deyoung, T, Dharani, S, Diaz, A, Díaz-Vélez, JC, Dujmovic, H, Dunkman, M, Duvernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evans, J, Evenson, PA, Fahey, S, Fazely, AR, Fiedlschuster, S, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, Franckowiak, A, Friedman, E, Fritz, A, Fürst, P, Gaisser, TK, and Gallagher, J
Subjects: Neutrino astronomy, High energy astrophysics, astro-ph.HE, astro-ph.IM, Astronomy & Astrophysics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural)
Abstract: In multi-messenger astronomy, rapid investigation of interesting transients is imperative. As an observatory with a 4π steradian field of view, and ∼99% uptime, the IceCube Neutrino Observatory is a unique facility to follow up transients, as well as to provide valuable insights for other observatories and inform their observational decisions. Since 2016, IceCube has been using low-latency data to rapidly respond to interesting astrophysical events reported by the multi-messenger observational community. Here, we describe the pipeline used to perform these followup analyses, and provide a summary of the 58 analyses performed as of July 2020. We find no significant signal in the first 58 analyses performed. The pipeline has helped inform various electromagnetic observation strategies, and has constrained neutrino emission from potential hadronic cosmic accelerators.
Published: 2021

197. Detection of a particle shower at the Glashow resonance with IceCube

Author: Aartsen, MG, Abbasi, R, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Ahrens, M, Alispach, C, Amin, NM, Andeen, K, Anderson, T, Ansseau, I, Anton, G, Arguelles, C, Auffenberg, J, Axani, S, Bagherpour, H, Bai, X, Balagopal, AV, Barbano, A, Barwick, SW, Bastian, B, Basu, V, Baum, V, Baur, S, Bay, R, Beatty, JJ, Becker, K-H, Tjus, J Becker, Bellenghi, C, BenZvi, S, Berley, D, Bernardini, E, Besson, DZ, Binder, G, Bindig, D, Blaufuss, E, Blot, S, Bohm, C, Boeser, S, Botner, O, Boettcher, J, Bourbeau, E, Bourbeau, J, Bradascio, F, Braun, J, Bron, S, Brostean-Kaiser, J, Burgman, A, Buscher, J, Busse, RS, Campana, MA, Carver, T, Chen, C, Cheung, E, Chirkin, D, Choi, S, Clark, BA, Clark, K, Classen, L, Coleman, A, Collin, GH, Conrad, JM, Coppin, P, Correa, P, Cowen, DF, Cross, R, Dave, P, De Clercq, C, DeLaunay, JJ, Dembinski, H, Deoskar, K, De Ridder, S, Desai, A, Desiati, P, de Vries, KD, de Wasseige, G, de With, M, DeYoung, T, Dharani, S, Diaz, A, Diaz-Velez, JC, Dujmovic, H, Dunkman, M, DuVernois, MA, Dvorak, E, Ehrhardt, T, Eller, P, Engel, R, Evenson, PA, Fahey, S, Fazely, AR, Fedynitch, A, Felde, J, Fienberg, AT, Filimonov, K, Finley, C, Fischer, L, Fox, D, and Franckowiak, A
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Affordable and Clean Energy, IceCube Collaboration, General Science & Technology
Abstract: The Glashow resonance describes the resonant formation of a W- boson during the interaction of a high-energy electron antineutrino with an electron1, peaking at an antineutrino energy of 6.3 petaelectronvolts (PeV) in the rest frame of the electron. Whereas this energy scale is out of reach for currently operating and future planned particle accelerators, natural astrophysical phenomena are expected to produce antineutrinos with energies beyond the PeV scale. Here we report the detection by the IceCube neutrino observatory of a cascade of high-energy particles (a particle shower) consistent with being created at the Glashow resonance. A shower with an energy of 6.05 ± 0.72 PeV (determined from Cherenkov radiation in the Antarctic Ice Sheet) was measured. Features consistent with the production of secondary muons in the particle shower indicate the hadronic decay of a resonant W- boson, confirm that the source is astrophysical and provide improved directional localization. The evidence of the Glashow resonance suggests the presence of electron antineutrinos in the astrophysical flux, while also providing further validation of the standard model of particle physics. Its unique signature indicates a method of distinguishing neutrinos from antineutrinos, thus providing a way to identify astronomical accelerators that produce neutrinos via hadronuclear or photohadronic interactions, with or without strong magnetic fields. As such, knowledge of both the flavour (that is, electron, muon or tau neutrinos) and charge (neutrino or antineutrino) will facilitate the advancement of neutrino astronomy.
Published: 2021

198. Seasonality of the Meridional Overturning Circulation in the subpolar North Atlantic

Author: Yao Fu, M. Susan Lozier, Tiago Carrilho Biló, Amy S. Bower, Stuart A. Cunningham, Frédéric Cyr, M. Femke de Jong, Brad deYoung, Lewis Drysdale, Neil Fraser, Nora Fried, Heather H. Furey, Guoqi Han, Patricia Handmann, N. Penny Holliday, James Holte, Mark E. Inall, William E. Johns, Sam Jones, Johannes Karstensen, Feili Li, Astrid Pacini, Robert S. Pickart, Darren Rayner, Fiammetta Straneo, and Igor Yashayaev
Subjects: Geology, QE1-996.5, Environmental sciences, GE1-350
Abstract: Abstract Understanding the variability of the Atlantic Meridional Overturning Circulation is essential for better predictions of our changing climate. Here we present an updated time series (August 2014 to June 2020) from the Overturning in the Subpolar North Atlantic Program. The 6-year time series allows us to observe the seasonality of the subpolar overturning and meridional heat and freshwater transports. The overturning peaks in late spring and reaches a minimum in early winter, with a peak-to-trough range of 9.0 Sv. The overturning seasonal timing can be explained by winter transformation and the export of dense water, modulated by a seasonally varying Ekman transport. Furthermore, over 55% of the total meridional freshwater transport variability can be explained by its seasonality, largely owing to overturning dynamics. Our results provide the first observational analysis of seasonality in the subpolar North Atlantic overturning and highlight its important contribution to the total overturning variability observed to date.
Published: 2023
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199. Burden of chemotherapy‐induced myelosuppression among patients with extensive‐stage small cell lung cancer: A retrospective study from community oncology practices

Author: Lowell Hart, Augustina Ogbonnaya, Kristen Boykin, Kathryn Deyoung, Ray Bailey, Trevor Heritage, Lorena Lopez‐Gonzalez, Huan Huang, and Lucio Gordan
Subjects: chemotherapy, community oncology, extensive‐stage small cell lung cancer, myelosuppression, retrospective, supportive care, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Myelosuppression is a major dose‐limiting complication of chemotherapy for patients with extensive‐stage small cell lung cancer (ES‐SCLC). The objective was to describe the burden of myelosuppression, treatment patterns, and supportive care use among patients with ES‐SCLC treated with chemotherapy in a US community oncology setting. Methods This retrospective cohort study used structured electronic medical record (EMR) data from the Florida Cancer Specialists & Research Institute between January 2013 and December 2020. Adult patients with ES‐SCLC who were treated with chemotherapy between September 2013 and November 2020 were identified. The index date was the date of the first chemotherapy‐containing line of therapy (LOT). Patients were followed for a minimum of 30 days after index (unless patient died) until December 31, 2020, or end of activity in the EMR data, whichever occurred first. Incidence and frequency of myelosuppressive episodes/events, treatment patterns, eligibility for red blood cell (RBC) or platelet transfusions, and supportive care use (granulocyte colony‐stimulating factor [G‐CSF], erythropoiesis‐stimulating agents [ESAs], intravenous [IV] hydration) during the follow‐up period were reported. Results The study population included 1239 patients. Most (94.0%) patients started first‐line chemotherapy at index. During follow‐up and across all chemotherapy‐containing LOTs, 1222 (98.6%) patients had at least 1 myelosuppressive episode; 62.1% of patients had grade ≥ 3 myelosuppressive episodes in at least one lineage, 33.9% had grade ≥ 3 myelosuppressive episodes in at least two lineages, and 15.5% had grade ≥ 3 myelosuppressive episodes in all three lineages. Supportive care use included 89.7% of patients who received G‐CSF, 24.4% who received ESAs, and 52.1% who received IV volume expansion. Almost one‐third (32.6%) of patients were eligible to receive RBC transfusions based on lab values (hemoglobin
Published: 2023
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200. The broad scale impact of climate change on planning aerial wildlife surveys with drone-based thermal cameras

Author: Annalysa M. Camacho, Humberto L. Perotto-Baldivieso, Evan P. Tanner, Amanda L. Montemayor, Walter A. Gless, Jesse Exum, Thomas J. Yamashita, Aaron M. Foley, Randy W. DeYoung, and Shad D. Nelson
Subjects: Medicine, Science
Abstract: Abstract Helicopters used for aerial wildlife surveys are expensive, dangerous and time consuming. Drones and thermal infrared cameras can detect wildlife, though the ability to detect individuals is dependent on weather conditions. While we have a good understanding of local weather conditions, we do not have a broad-scale assessment of ambient temperature to plan drone wildlife surveys. Climate change will affect our ability to conduct thermal surveys in the future. Our objective was to determine optimal annual and daily time periods to conduct surveys. We present a case study in Texas, (United States of America [USA]) where we acquired and compared average monthly temperature data from 1990 to 2019, hourly temperature data from 2010 to 2019 and projected monthly temperature data from 2021 to 2040 to identify areas where surveys would detect a commonly studied ungulate (white-tailed deer [Odocoileus virginianus]) during sunny or cloudy conditions. Mean temperatures increased when comparing the 1990–2019 to 2010–2019 periods. Mean temperatures above the maximum ambient temperature in which white-tailed deer can be detected increased in 72, 10, 10, and 24 of the 254 Texas counties in June, July, August, and September, respectively. Future climate projections indicate that temperatures above the maximum ambient temperature in which white-tailed deer can be detected will increase in 32, 12, 15, and 47 counties in June, July, August, and September, respectively when comparing 2010–2019 with 2021–2040. This analysis can assist planning, and scheduling thermal drone wildlife surveys across the year and combined with daily data can be efficient to plan drone flights.
Published: 2023
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