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•In MUD allo-HCT, the use of 2 mg/kg ATG combined with PTCy and CsA [ATG(2)/PTCy] effectively prevents GVHD and results in comparable relapse risk and OS to the use of ATG(4.5)/PTCy and ATG-based prophylaxis, but with lower NRM.•In patients who received ATG(2)/PTCy, the incidences of grade II-IV and grade III-IV aGVHD at day +100 and moderate/severe cGVHD at 1 year were 23.3%, 8.0%, and 14.1%, respectively.

•Blinatumomab is associated with improved post-transplant survival in B-ALL patients.•Blinatumomab is not associated with increased relapse post-transplant.•Blinatumomab is safe in the setting of post-transplant cyclophosphamide.

Adenosine triphosphate (ATP)-binding cassette (ABC) transporter systems are divided into importers and exporters that facilitate the movement of diverse substrate molecules across the lipid bilayer, against the concentration gradient. These transporters comprise two highly conserved nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). Unlike ABC exporters, prokaryotic ABC importers require an additional substrate-binding protein (SBP) as a recognition site for specific substrate translocation. The discovery of a large number of ABC systems in bacterial pathogens revealed that these transporters are crucial for the establishment of bacterial infections. The existing literature has highlighted the roles of ABC transporters in bacterial growth, pathogenesis, and virulence. These roles include importing essential nutrients required for a variety of cellular processes and exporting outer membrane-associated virulence factors and antimicrobial substances. This review outlines the general structures and classification of ABC systems to provide a comprehensive view of the activities and roles of ABC transporters associated with bacterial virulence and pathogenesis during infection.

The study aimed to assess dry matter dynamics of forests along treeline ecotone concerning environmental variability, and four representative forests, birch, kharsu oak, Himalayan fir and mixed forest along treeline ecotone (3250–3400 m asl) were selected in Kedarnath Wildlife Sanctuary, Western Himalaya. Temperature, precipitation and humidity data were recorded for complete 3 years (2008–2010). Field inventory for assessment of forest structure and dry matter was carried out in a 200 m transect in each forest along treeline using quadrats of different sizes for tree, shrub and herb layers. The biomass and net primary productivity (NPP) of woody vegetation was estimated using region-specific allometric equations and of the herb layer, by harvesting. Litter quantity and decomposition rates were assessed using litter traps and litter bags, respectively. The dry matter budget of treeline ecotone was represented using a compartment model. The mean annual temperature at treeline was recorded 6.6 ± 0.68 °C with warmest month average temperature of 12.6 ± 1.2 °C. The average forest biomass at ecotone was 33.27 ± 16.97 Mg/0.1 ha, ranged between 8.87 Mg/0.1 ha in open and early successional birch forest to 44.98 Mg/0.1 ha in dense canopy mixed forest. NPP ranged from 1.49 to 2.11 Mg/0.1 ha year−1. The birch forest exhibited the highest efficiency in annual dry matter accumulation in the canopy layer among all forests. The leaf litter decomposition rates (% weight loss) was highest for kharsu oak (74%) after 3 years. The study revealed that Western Himalayan treeline exhibit warmer summer and higher amounts of dry matter storage, production and decomposition rates. These treeline forests showed a higher dry matter assimilation rate and so the potential for carbon sequestration under a warming climate.

Achieving enhanced and stable electrical quality of scalable graphene is crucial for practical graphene device applications. Accordingly, encapsulation has emerged as an approach for improving electrical transport in graphene. In this study, we demonstrate high-current treatment of graphene passivated by AlOxnanofilms as a new means to enhance the electrical quality of graphene for its scalable utilization. Our experiments and electrical measurements on large-scale chemical vapor-deposited (CVD) graphene devices reveal that high-current treatment causes persistent and irreversible de-trapping density in both bare graphene and graphene covered by AlOx. Strikingly, despite possible interfacial defects in graphene covered with AlOx, the high-current treatment enhances its carrier mobility by up to 200% in contrast to bare graphene samples, where mobility decreases. Spatially resolved Raman spectroscopy mapping confirms that surface passivation by AlOx, followed by the current treatment, reduces the number of sp3defects in graphene. These results suggest that for current treated-passivated graphene (CTPG), the high-current treatment considerably reduces charged impurity and trapped charge densities, thereby reducing Coulomb scattering while mitigating any electromigration of carbon atoms. Our study unveils CTPG as an innovative system for practical utilization in graphene nanoelectronic and spintronic integrated circuits.