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А para-chlorophenyl substituent was firstly obtained into the structure of pyridyl-substituted 4-nitrosopyrazole by cyclocondensation of hydrazine hydrate with the corresponding isonitroso-β-dicarbonyl compounds. The structure of previously unknown 3(5)-(4-chlorophenyl)-5(3)-pyridine-(3(4))-yl-4-nitroso-1H-pyrazoles and previously obtained 3(5)-alkyl(aryl)-5(3)-pyridine-(3(4))-yl-4-nitroso-1H-pyrazoles is proved and studied in detail by modern methods of analysis: mass spectrometry, 1H- and 13C NMR-spectroscopy

The article studies the influence of the resource status of regions on the formation of the country's budget based on the tools of the panel data model. The article reviews the Russian and foreign literature, systematizes methodological approaches to the concept of "resource-type region", and identifies the most significant factors that affect the socio-economic life of the regions where GRP was selected as a dependent variable. As a result of the work, it was shown how the characteristics of the regions change depending on their affiliation.

Noncoding RNAs play a crucial role in various cellular processes in living organisms, and RNA functions heavily depend on molecule structures composed of stems, loops, and various tertiary motifs. Among those, the most frequent are A-minor interactions, which are often involved in the formation of more complex motifs such as kink-turns and pseudoknots. We present a novel classification of A-minors in terms of RNA secondary structure where each nucleotide of an A-minor is attributed to the stem or loop, and each pair of nucleotides is attributed to their relative position within the secondary structure. By analyzing classes of A-minors in known RNA structures, we found that the largest classes are mostly homogeneous and preferably localize with known A-minor co-motifs, such as tetraloop–tetraloop receptor and coaxial stacking. Detailed analysis of local A-minors within internal loops revealed a novel recurrent RNA tertiary motif, the across-bulged motif. Interestingly, the motif resembles the previously known GAAA/11nt motif but with the local adenines performing the role of the GAAA-tetraloop. By using machine learning, we show that particular classes of local A-minors can be predicted from sequence and secondary structure. The proposed classification is the first step toward automatic annotation of not only A-minors and their co-motifs but various types of RNA tertiary motifs as well.

Text manipulation suggests active speech production activity of students in comprehending, reproducing and producing texts. The authors of the article have proved the need to use health-saving technology in the process of speech production development of students. It is concluded that projecting health promotion speech creative activity of students contributes to didactic solutions. The possibilities of using health-saving technology in the process of speech production development of students have been considered by means of an example of organizing speech creative project and speech creative work en plein air in high school, and an overall conclusion about the effectiveness of using this technology in the process of teaching Russian language and literature has been made.

Objective. To study the sanitary and parasitological state of food products in Astrakhan Region for their contamination with eggs and larvae of helminths, as well as cysts of pathogenic intestinal protozoa. Materials and methods . The work was carried out on the basis of the Laboratory of Bacteriological and Parasitological Research of the Center for Hygiene and Epidemiology in the Astrakhan Region in 2015–2019. A total of 1.430 food samples were examined and 2207 studies were performed during the analyzed period. The number of unsatisfactory samples was 4.6 % ( n = 66) – the following was found: larvae of Strongyloides stercoralis – 84.8 % ( n = 56), eggs and metacercariae of Opisthorchis felineus – 4.5 % ( n = 3), cysts of Entamoeba histolytica , larvae of Strongyloides stercoralis + Ascaris lumbricoides – 3.0 % ( n = 2), eggs of Ascaris lumbricoides and Enterobius vermicularis – 1.5 % ( n = 1) and larvae of Strongyloides stercoralis + Toxocara Canis – 1.5 % ( n = 1). Results. The largest number of selected and investigated food samples was accounted for fruit and vegetable samples – 54.3 % ( n = 777), of which 8.4 % ( n = 65) of the samples were unsatisfactory. In these samples, larvae of Strongyloides stercoralis were found – 86.2 % ( n = 56) of all positive findings of fruit and vegetable products, eggs of Opisthorchis felineus and cysts of Entamoeba histolytica – 3.1 % ( n = 2 each), as well as unfertilized eggs of Ascaris lumbricoides and eggs of Enterobius vermicularis – 1.5 % ( n = 1 each). In addition to isolated findings, there were noted cases of mixed invasion: larvae of Strongyloides stercoralis + unfertilized eggs of Ascaris lumbricoides -3.1 % ( n = 2) and larvae of Strongyloides stercoralis + eggs of Toxocara canis – 1.5 % ( n = 1). Conclusions. The presence of Toxocara eggs and strongylid larvae on the samples of fruit and vegetable products indicates soil contamination with feces of invasive animals. The presence of ascarid eggs on food indicates contamination of the soil with the feces of infested persons. The presence of opisthorchis eggs on the samples of cucumbers and tomatoes, and cysts of dysentery amoeba on the samples of cucumbers and cabbage indicates contamination of water used for watering these products with eggs and cysts of pathogenic intestinal protozoa. The presence of pinworm eggs on cucumbers indicates contact of an infected person with this product. Contamination may have occurred when the product was transported to the laboratory.

Aim of the study was to analyze the event-related synchronization/desynchronization of brain electrical activity during visual selection task in patients underwent on-pump coronary artery bypass grafting (CABG) with and without postoperative cognitive dysfunction (POCD). Material and methods. The study included 32 men who underwent on-pump CABG, mean age 57.2 ± 6.08 years. All patients carried out extended neuropsychological testing, a multi-channel computer electroencephalography (EEG) 3-5 days before CABG and on the 7-10th day after the surgery. The POCD was determined according to the criterion: 20 % decrease in the cognitive indicator compared to that at baseline on 20 % of the tests included in the neuropsychological battery. Monopolar EEGs were recorded in 62 sites of 10-20 system with NEUVO encephalograph (Compumedics, USA) during cognitive task performing in patients wi h and without POCD. Statistical processing was performed using the STATISTICA 10.0. Results. It was found that the POCD patients had less pronounced theta desynchronization in the left frontal-central regions during the stage of 200-400 ms at the 7-10 days after CABG in comparison to patients without cognitive decline. Moreover, in the left parietal leads POCD patients had decreased theta desynchronization during the stage of 200-400 ms even before the surgery. At the 7-10 days after CABG, only the patients without POCD had a decrease of event-related theta activity in the left parietal leads compared with baseline. During the stage of 600-800 ms, the POCD patients had a lower degree of theta-desynchronization of both frontal-central and parietal regions of right hemisphere compared to patients without cognitive decline. Conclusion. The cognitive decline in patients after CABG determined according to neuropsychological testing is accompanied by pathological changes in the event-related theta activity. An analysis of event-related synchronization/desynchronization can be used both as predictor of postoperative cognitive impairment and as objective marker of POCD.

Hypothesis/Aims of study. Obesity and severe chronic somatic pathology in a woman leads to a rapid depletion of compensatory and adaptive reserves of the placenta and to the progression of circulatory and dystrophic changes, which causes intrauterine growth retardation and reduces the likelihood of a favorable course of pregnancy and childbirth. The aim of this study was to assess the morphological features of the vascular component of placental villi in obese women. Study design, materials and methods. Histological and immunohistochemical studies were conducted on 41 placentas from obese patients with and without gestational diabetes mellitus and from healthy patients, endothelial marker CD34+ expression being assessed in chorionic villi. Results. In obese patients, chronic placental insufficiency is presented in most cases as a dissociated form with persistence of not only mature but also immature villi, which indicates early structural pathology of the placenta. Conclusion. Obesity in women contributes to more frequent chronic placental insufficiency with severe circulatory disorders and varying degrees of severity of compensatory and adaptive changes.

Polycystic ovary syndrome is one of the most common pathologies in the practice of an obstetrician-gynecologist. Overcoming infertility characteristic of this syndrome is an important problem of endocrinology, gynecology, and reproductive medicine. Innovative therapeutic and surgical methods of treatment can correct hormonal and metabolic disorders, induce ovulation and achieve a long-awaited pregnancy. Early gestation periods in patients with polycystic ovary syndrome often occur with miscarriage, and the risks of developing gestational diabetes mellitus, cervical insufficiency, gestational arterial hypertension, preeclampsia, and placental insufficiency increase. We have analyzed modern ideas about the effect of various pathogenetic links of polycystic ovary syndrome on the course of pregnancy.

Backgraund. Spleen surgery is mainly aimed to achieve effective hemostasis. The increasing popularity of topical hemostatic drugs is limited by their common side effect associated with the development of adhesions.The aim of study was to develop a new hemostatic drug with anti-adhesion activity. To achieve this, the authors have investigated 6% sodium carboxymethylcellulose gel with the addition of 5% aminocaproic acid. Materials and methods. The efficacy of the sample was studied experimentally in laboratory animals (rats, n = 87). The time of bleeding arrest, the amount of blood loss, the severity of the adhesion process, morphological and histological changes in tissues in the area of material implantation were assessed.Results. The study results evidenced that the new hemostatic drug reduced bleeding time by 68% (222.27 sec) and blood loss by 69% (285.6 mg) (p 0.01) after partial splenectomy, and prevented the development of adhesive process compared to the results obtained in the animals of the control group. On the 3rd day of the experiment application of the sample demonstrated that adhesions were completely absent, the coefficient of the severity of the adhesive process was 0 points; on the 7th and 14th days it was minimal - 0.481 and 0.486 points, respectively (p 0.05). A morphological study showed that the use of the new composite reduced the white pulp immunological reactivity associated with postoperative inflammatory processes, which is manifested by smaller lymphoid follicles and lower CD4 + T-lymphocytes expression.Conclusions. Thus, 6% sodium carboxymethylcellulose gel with the addition of 5% aminocaproic acid is an effective combined hemostatic and anti-adhesion agent that can be effectively applied in spleen surgery.

The article presents an experience in reconstructing the history of the Federation of Associations of Soviet writers (FASW) based on archived primary sourceson from the Department of manuscripts of the IWL RAS, which are being for the first time introduced into scientific circulation. The history of the FASW (FOSP) is the history of the struggle of proletarian organizations for the leadership of the entire Federation. The main method of manipulation was the Communist faction of the FASW headed by A.A. Fadeev, which was controlled by the press Department of the Central Committee of the CPSU(b). The Federation duplicated trade Union functions provided its members with housing, the opportunity to relax, travel abroad, and helped reduce taxes on the income of writers. The Federation was funded by the Narkompros. The history of the FASW shows that after the end of the NEP, the existence оf the institute of literature became directly dependent on the nature of the relationship with the only counterparty — the state with which the writers concluded employment contracts. At the end of the first five-year plan, the Federation was an extra link in the business communication between the writer and the state, which required a significant budget and refracted the voice of power with the interpretations of self-appointed ideologues.

The article deals with the problem of searching and selecting information. Currently, this kind of problem is solved by using search information systems. The main stage of creating a search information system is the development of the project, which is carried out using the unified modeling language UML and the CASE tool Power Designer. When developing a system project using the UML modeling language, all available information about the designed system is represented as a set of graphical elements, in other words, graphical structures. Such constructions are called diagrams. They reflect the essence of the system and consider it from different sides and represent the processes that take place in it in different ways.

Obesity is a significant health and social problem that is the scale of the growing worldwide epidemic. Over the past 10 years, the number of obese pregnant women has doubled. There are multiple risk factors associated with obesity, which includes poor nutrition, foods that are high in easily digestible carbohydrates and fats, frequent snacks, and widespread fast food consumption. Metabolic changes, especially in women with the genetic predisposition, are manifested by insulin resistance, hyperinsulinemia, arterial hypertension, and hypercoagulation syndrome. The course of pregnancy and childbirth in obese women is associated with a series of successive pathological conditions, such as miscarriage, the occurrence of gestational diabetes mellitus, preeclampsia and eclampsia, infectious complications, prolonged pregnancy, the occurrence of bleeding and much more. We have analyzed modern ideas about womens reproductive health and the course of pregnancy and childbirth in obesity.

Excited-state relaxation of a prototypical ruthenium nitrosyl complex (pentachloronitrosylruthenate) in water is studied by means of ultrafast dispersed, broadband transient absorption spectroscopy. Excitation pulses (duration, 40-70 fs) utilized at seven different wavelengths in the range from 675 to 335 nm populated excited electronic states of different orbital nature. The second excited singlet state of π

Purpose This paper aims to study the mathematical modeling of passive cooling systems for electronic devices. Improving heat transfer is facilitated by the correct choice of the working fluid and the geometric configuration of the engineering cavity; therefore, this work is devoted to the analysis of the influence of the position of the heat-generating element and the tilted angle of the electronic cabinet on the thermal convection of a non-Newtonian fluid. Design/methodology/approach The area of interest is a square cavity with two cold vertical walls, while the horizontal boundaries are adiabatic. An element of constant volumetric heat generation is placed on the lower wall of the chamber. The problem is described by Navier–Stokes partial differential equations using dimensionless stream function and vorticity. The numerical solution is based on the developed computational code using the finite difference technique and a uniform rectangular grid. Findings The key conclusions of this work are the results of a detailed analysis of streamlines and isotherms, the average Nusselt number and profiles of the average heater temperature. It was found that more intensive cooling of the heat-generating element occurs when the cavity is filled with a pseudoplastic fluid (n 5 and the thermal conductivity ratio of k = 100 are characterized by the most positive effect. Originality/value The originality of the research lies in both the study of thermal convection in a square chamber filled with power-law fluid under the influence of a volumetric heat production element and the analysis of the influence of geometric and thermophysical parameters characterizing the considered process.

The capabilities of fully functional geographic information systems used in various fields make it possible to simulate the characteristics of the gravitational field, presenting measuring information in the form of continuous surfaces, thereby expanding the area of use of data on the Earth's gravitational field. An important stage of visualization is the choice of a method of interpolating data that provides the highest possible accuracy in creating a digital model of the studied characteristic of the gravitational field. The authors developed a technology for choosing the optimal method for interpolating the characteristics of the Earth's gravitational field in a GIS to create models with an assessment of their accuracy according to the initial data, presented in the form of a technological scheme. The possibilities of the Golden Software Surfer software product for creating a model of quasi-geoid heights from the unevenly presented satellite and geometric leveling data in the study area are considered. A method for interpolating the heights of a quasi-geoid in Golden Software Surfer is proposed, a model of a quasi-geoid in a local area is created. An assessment of the accuracy of the created model according to the initial data is performed.

The population and structural dynamics of IrCl62− is studied in acetonitrile and aqueous solutions in comparison to isoelectronic IrBr62− using ultrafast broadband, dispersed transient absorption, with both octahedra excited with 85 fs pulses at four different wavelengths, encompassing the first seven t2g-based electronic states. Ligand-to-metal charge transfer (LMCT) 420 or 490 nm excitation of IrCl62− into Uu′(2T2u) + Eu′′(2T2u) states, superimposed due to Ham effect, or Uu′(2T1u), respectively, leads to symmetry lowering due to Jahn–Teller effect in these excited states with the subsequent 100 fs decay into Ug′(2T1g). This first LMCT state is formed vibrationally coherent in the 104 cm−1 t2g (scissor) or 243 cm−1 eg (out-of-phase-stretch) Jahn–Teller modes for the respective excitation wavelength. Direct excitation into Ug′(2T1g) at 600 nm and the intraconfigurational lowest excited Ug′(2T2g) state at 1900 nm helped to establish that Ug′(2T1g) decays via back electron transfer into Ug′(2T2g) (time constants, 3.55 ps in acetonitrile and 0.9 ps in water), and the decay of Ug′(2T2g) into the ground state is the rate-limiting relaxation step. The relaxation cascade of IrBr62− is similar with short-lived (≤100 fs) higher LMCT states, but the vibrational coherence is only observed in the Jahn–Teller t2g mode. Faster back electron transfer for IrBr62− is explained by the energy gap law. The intraconfigurational Ug′(2T2g) states, which are ∼5100 cm−1 above the ground state for both complexes, have a sub-nanosecond lifetime largely independent of the ligand nature (∼350 ps, acetonitrile).

This study is dedicated to identifying residential areas of the Metropolis of Lyon, which combines territorial and ethnic exclusion. In the framework of this study, territorial exclusion is understood as the territorial isolation of residential areas from the main residential area of the agglomeration due to the presence of various kinds of territorial barriers: water bodies, industrial and commercial areas, parklands, large highways. Ethnic exclusion in this study is understood as a partial exclusion from society (social exclusion) of population groups that are ethnically different from the main part of the population. The share of immigrants in the population of the communes and the share of social housing in the total housing stock of the communes of the Metropolis of Lyon were used as markers of ethnic exclusion. A comparison of territorially isolated residential quarters and data on the share of immigrants and the share of social housing revealed social housing quarters that combine signs of ethnic and territorial exclusion of the population: Mas-du-Taureau in the commune Vaulx-en-Velin in the north-east of the Metropolis of Lyon, Parilly and Terraillon in Bron in the east, Minguettes in Vénissieux in the south of the metropolitan area. During the interview, these social housing complexes were called by experts as the most disadvantaged and criminalized in the Metropolis of Lyon, which confirms the author’s hypothesis about the importance of territorial exclusion in the emergence and development of ethnic exclusion.

To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes.The single-center, non-randomized prospective study included 190 patients with community-acquired pneumonia caused by coronavirus 2 between the beginning of March and the end of May 2020. Of these, 89 patients received tocilizumab and 101 patients received sarilumab. The study inclusion criterion for the patient was indications for initiating therapy with one of the inhibitors of IL-6 receptors (anti-IL-6R) according to the Interim guidelines (versions 4 and 5). The exclusion criterion was the need to re-prescribe genetically engineered biological therapy (GEBT). The severity of the patient's condition was assessed according to the early warning score (NEWS2), the volume of lung tissue lesions was assessed according to computed tomography (CT). Laboratory monitoring included counting the absolute (abs) number of lymphocytes, serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), D-dimer, lactate dehydrogenase, fibrinogen. Statistical data processing was conducted by nonparametric methods using the IBM SPSS Statistics V-22 software.The phenotype of a patient with a negative outcome prognosis was described: a male patient over 50 years of age with aggravated premorbid background (with cardiovascular diseases, obesity and/or chronic renal disease), lung lesion CT 34, saturation less than 93% upon inhalation of atmospheric air, persisting for 2448 hours after GEBT. According to the blood test, lymphopenia was below 1000 U/L and CRP levels were above 50 mg/L. The laboratory parameters and clinical picture of the patient progressively worsened after 911 days of illness, regardless of the use of Anti-IL-6R. The features of patients monitoring when administering IL-6 receptor blockers have been determined.IL-6 receptor blockers should be administered to patients hospitalized with severe COVID-19 before the development of hyperinflammatory reactions. The optimal "therapeutic window" is 78 days of illness.Цель. Определить критерии оптимального применения блокаторов рецепторов интерлейкина (ИЛ)-6 у пациентов с внебольничной пневмонией COVID-19 на основе предикторов неблагоприятных исходов. Материалы и методы. В одноцентровое нерандомизированное проспективное исследование включены 190 пациентов с внебольничной пневмонией, вызванной коронавирусом-2, в период с начала марта до конца мая 2020 г. Из них 89 человек получили тоцилизумаб, а 101 пациент сарилумаб. Критерий включения в исследование показания для инициации терапии одним из ингибиторов рецепторов ИЛ-6 (анти-ИЛ-6Р) согласно Временным методическим рекомендациям (версии 4 и 5). Критерий исключения необходимость повторного назначения генно-инженерной биологической терапии. Тяжесть состояния пациента оценивалась по шкале раннего реагирования (NEWS2), объему поражения легочной ткани по данным компьютерной томографии. Лабораторный мониторинг включал: подсчет абсолютного количества лимфоцитов, уровни в сыворотке крови С-реактивного белка, ИЛ-6, D-димера, лактатдегидрогеназы, фибриногена. Статистическая обработка данных проводилась непараметрическими методами в программе IBM SPSS Statistics V-22. Результаты. Описан фенотип пациента с негативным прогнозом исхода: пациент мужского пола старше 50 лет с отягощенным преморбидным фоном (с сердечно-сосудистыми заболеваниями, ожирением и/или с хронической почечной патологией), объемом поражения легких по компьютерной томографии 34, сатурацией менее 93% при вдыхании атмосферного воздуха, сохраняющейся в течение 2448 ч после генно-инженерной биологической терапии. В анализе крови лимфопения ниже 1000 Ед/л и уровень C-реактивного белка выше 50 мг/л. Лабораторные показатели и клиническая картина пациента прогрессивно ухудшались после 911-го дня болезни, независимо от применения анти-ИЛ-6Р. Определены особенности мониторинга пациентов при назначении блокаторов рецепторов ИЛ-6Р. Заключение. Назначение блокаторов ИЛ-6Р пациентам, госпитализированным с тяжелой формой COVID-19, должно опережать развитие гипервоспалительных реакций. Оптимальным терапевтическим окном является 78-й день болезни.