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1,239 results on '"Dalle, Jean‐Hugues"'

151. Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)

Author

Grain, Audrey, primary, Rialland-Battisti, Fanny, additional, Chevallier, Patrice, additional, Blin, Nicolas, additional, Dalle, Jean-Hugues, additional, Michel, Gérard, additional, Dhédin, Nathalie, additional, Peffault de Latour, Regis, additional, Pochon, Cécile, additional, Yakoub-Agha, Ibrahim, additional, Bertrand, Yves, additional, Sirvent, Anne, additional, Jubert, Charlotte, additional, Forcade, Edouard, additional, Berceanu, Ana, additional, Gandemer, Virginie, additional, Schneider, Pascale, additional, Bay, Jacques-Olivier, additional, Rohrlich, Pierre-Simon, additional, Brissot, Eolia, additional, Paillard, Catherine, additional, Plantaz, Dominique, additional, Nguyen Quoc, Stéphanie, additional, Gonzales, Fanny, additional, Maillard, Natacha, additional, Planche, Lucie, additional, and Baruchel, André, additional

Published
2022
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153. Two Distinct Fetal-Type Signatures Caracterise Juvenile Myelomonocytic Leukemia

Author

Strullu, Marion, primary, Arfeuille, Chloé, additional, CAYE-EUDE, Aurélie, additional, Maillard, Loïc, additional, Lainey, Elodie, additional, Piques, Florian, additional, Fenneteau, Odile, additional, Bruno, Cassinat, additional, Fabien, Guimiot, additional, Dalle, Jean-Hugues, additional, Baruchel, André, additional, Chomienne, Christine, additional, Bonnet, Dominique, additional, Souyri, Michele, additional, and Cave, Helene, additional

Published
2022
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154. Final Long-Term Results from the Defifrance Registry Study: Efficacy and Safety of Defibrotide (DF) for the Treatment of Severe/Very Severe Veno-Occlusive Disease/ Sinusoidal Obstruction Syndrome (VOD/SOS) after Hematopoietic Cell Transplantation (HCT)

Author

Mohty, Mohamad, primary, Blaise, Didier, additional, de Latour, Régis Peffault, additional, Labopin, Myriam, additional, Detrait, Marie, additional, Huynh, Anne, additional, Labussière-Wallet, Hélène, additional, Lamy, Thierry, additional, Lebon, Delphine, additional, Maury, Sébastien, additional, Renard, Cecile, additional, Asubonteng, Kobby, additional, Delaval, Floriane, additional, Yakoub-Agha, Ibrahim, additional, and Dalle, Jean-Hugues, additional

Published
2022
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155. Prospective Trial of Ibrutinib for the Treatment of Pediatric Chronic Graft-Versus-Host Disease

Author

Carpenter, Paul A., primary, Kang, Hyoung Jin, additional, Yoo, Keon Hee, additional, Zecca, Marco, additional, Cho, Bin, additional, Lucchini, Giovanna, additional, Nemecek, Eneida R., additional, Schultz, Kirk R., additional, Stepensky, Polina, additional, Chaudhury, Sonali, additional, Oshrine, Benjamin, additional, Khaw, Seong Lin, additional, Harris, Andrew C., additional, Verna, Marta, additional, Zubarovskaya, Ludmila, additional, Lee, Yihua, additional, Wahlstrom, Justin, additional, Styles, Lori, additional, Shaw, Peter J., additional, and Dalle, Jean-Hugues, additional

Published
2022
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156. Defibrotide (DF) Treatment in Pediatric (ped) and Adult Patients (pts) with Severe or Very Severe Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) after Hematopoietic Cell Transplantation (HCT): Final Results from the Defifrance Study

Author

Mohty, Mohamad, primary, Blaise, Didier, additional, de Latour, Régis Peffault, additional, Labopin, Myriam, additional, Detrait, Marie, additional, Huynh, Anne, additional, Labussière-Wallet, Hélène, additional, Lamy, Thierry, additional, Lebon, Delphine, additional, Maury, Sébastien, additional, Renard, Cecile, additional, Asubonteng, Kobby, additional, Delaval, Floriane, additional, Yakoub-Agha, Ibrahim, additional, and Dalle, Jean-Hugues, additional

Published
2022
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157. Comparison of Outcomes in Patients with Cerebral Adrenoleukodystrophy (CALD) Receiving Elivaldogene Autotemcel (eli-cel; Lenti-D) Gene Therapy in Clinical Trials Versus Those Receiving Allogeneic Hematopoietic Stem Cell Transplant in a Contemporaneous Comparator Study

Author

Duncan, Christine N., primary, Kühl, Jörn-Sven, additional, Chiesa, Robert, additional, Boelens, Jaap-Jan, additional, Eichler, Florian, additional, Sevin, Caroline, additional, Dalle, Jean-Hugues, additional, De Oliveira, Satiro N., additional, Amartino, Hernan M., additional, Kapoor, Neena, additional, Prasad, Vinod K., additional, Jones, Simon, additional, Algeri, Mattia, additional, Bunin, Nancy J., additional, Diaz-de-Heredia, Cristina, additional, Thrasher, Adrian J., additional, Fernandes, Juliana Folloni, additional, Smith, Nicholas, additional, Shah, Ami J, additional, Locatelli, Franco, additional, Engelen, Marc, additional, Lindemans, Caroline A., additional, Dietz, Andrew C., additional, Pan, Lin, additional, Sieker, Jakob, additional, Williams, David A., additional, and Orchard, Paul J., additional

Published
2022
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158. Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants.

Author

Faust, Cindy, Auquier, Pascal, Hamidou, Zeinab, Bertrand, Yves, Tabone, Marie‐Dominique, Ansoborlo, Sophie, Baruchel, André, Gandemer, Virginie, Dalle, Jean‐Hugues, Chastagner, Pascal, Kanold, Justyna, Poirée, Maryline, Sirvent, Nicolas, Plat, Geneviève, Pellier, Isabelle, Michel, Gérard, and Berbis, Julie

Subjects
ACUTE leukemia, QUALITY of life, SISTERS, SIBLINGS, FRENCH people
Abstract

Background: Childhood cancer confront the whole family with a traumatic event. Because brothers and sisters may encounter emotional problems that can remain for a long time and that only few studies have assessed their long‐term outcome, our present objectives were to describe the long‐term quality of life (QoL) of childhood leukemia survivors' siblings and to explore its determinant. Methods: Brothers and sisters (from 8‐year‐old) of survivors included in the French LEA Cohort completed a QoL questionnaire (according to their age). Scores were compared with those reported by age‐ and gender‐matched French general population and by survivors. Using a clustering method, siblings were categorized into 3 groups depending on their level of QoL's scores and factors likely to be linked with these clusters were explored with multivariate analyses. Results: We included 689 brothers and sisters (313 minors, 376 adults) and the mean time from diagnosis was 13.2 ± 6.6 years. Minor siblings reported higher QoL scores than general population (p < 0.001), but a lower score for relationship with family than survivors (p < 0.001). In adult siblings, Mental Component Summary score was lower than general population (p < 0.001). Level of siblings' QoL was linked with female gender, but no association was found with cancer‐related factors. Conclusion: Brothers and sisters expressed a divergent perception of their long‐term QoL depending on their age. To minimize the impact from childhood to adulthood, long‐term attention should also be paid to siblings, often referred as "forgotten children". [ABSTRACT FROM AUTHOR]

Published
2023
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163. Human MAIT cells are devoid of alloreactive potential: prompting their use as universal cells for adoptive immune therapy

Author

Tourret, Marie, Talvard-Balland, Nana, Lambert, Marion, Ben Youssef, Ghada, Chevalier, Mathieu F, Bohineust, Armelle, Yvorra, Thomas, Morin, Florence, Azarnoush, Saba, Lantz, Olivier, Dalle, Jean-Hugues, and Caillat-Zucman, Sophie

Subjects
Adult, Male, Immune Cell Therapies and Immune Cell Engineering, Adolescent, Infant, Newborn, Infant, Adaptive Immunity, Middle Aged, adoptive, Mucosal-Associated Invariant T Cells, Young Adult, Child, Preschool, Humans, Female, Immunotherapy, transplantation immunology, Child, Aged
Abstract

Background Mucosal-associated invariant T (MAIT) cells are semi-invariant T cells that recognize microbial antigens presented by the highly conserved MR1 molecule. MAIT cells are predominantly localized in the liver and barrier tissues and are potent effectors of antimicrobial defense. MAIT cells are very few at birth and accumulate gradually over a period of about 6 years during the infancy. The cytotoxic potential of MAIT cells, as well as their newly described regulatory and tissue repair functions, open the possibility of exploiting their properties in adoptive therapy. A prerequisite for their use as ‘universal’ cells would be a lack of alloreactive potential, which remains to be demonstrated. Methods We used ex vivo, in vitro and in vivo models to determine if human MAIT cells contribute to allogeneic responses. Results We show that recovery of MAIT cells after allogeneic hematopoietic stem cell transplantation recapitulates their slow physiological expansion in early childhood, independent of recovery of non-MAIT T cells. In vitro, signals provided by allogeneic cells and cytokines do not induce sustained MAIT cell proliferation. In vivo, human MAIT cells do not expand nor accumulate in tissues in a model of T-cell-mediated xenogeneic graft-versus-host disease in immunodeficient mice. Conclusions Altogether, these results provide evidence that MAIT cells are devoid of alloreactive potential and pave the way for harnessing their translational potential in universal adoptive therapy overcoming barriers of HLA disparity. Trial registration number ClinicalTrials.gov number NCT02403089.

Published
2021

164. Allogeneic hematopoietic stem cell transplantation in children and adolescents with recurrent and refractory Hodgkin lymphoma: an analysis of the European Group for Blood and Marrow Transplantation

Author

Claviez, Alexander, Canals, Carme, Dierickx, Daan, Stein, Jerry, Badell, Isabel, Pession, Andrea, Mackinnon, Stephen, Slavin, Shimon, Dalle, Jean-Hugues, Chacón, Manuel Jurado, Sarhan, Mahmoud, Wynn, Robert Francis, Suttorp, Meinolf, Dini, Giorgio, Sureda, Anna, and Schmitz, Norbert

Published
2009
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165. Minimal residual disease quantification in ovarian tissue collected from patients in complete remission of acute leukemia

Author

Chevillon, Florian, Clappier, Emmanuelle, Arfeuille, Chloé, Cayuela, Jean-Michel, Dalle, Jean Hugues, Kim, Rathana, Caye-Eude, Aurélie, Chalas, Céline, Abdo, Chrystelle, Drouineaud, Véronique, Peffault de Latour, Régis, Alcantara, Marion, Uzunov, Madalina, Degaud, Michael, Meignin, Véronique, Dombret, Hervé, Boissel, Nicolas, Poirot, Catherine, and Dhédin, Nathalie

Published
2021
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166. Follow-up of post-transplant minimal residual disease and chimerism in childhood lymphoblastic leukaemia: 90 d to react

Author

Pochon, Cécile, Oger, Emmanuel, Michel, Gérard, Dalle, Jean-Hugues, Salmon, Alexandra, Nelken, Brigitte, Bertrand, Yves, Cavé, Hélène, Cayuela, Jean-Michel, Grardel, Nathalie, Macintyre, Elizabeth, Margueritte, Geneviève, Méchinaud, Françoise, Rohrlich, Pierre, Paillard, Catherine, Demeocq, François, Schneider, Pascale, Plantaz, Dominique, Poirée, Marilyne, Eliaou, Jean-François, Semana, Gilbert, Drunat, Séverine, Jonveaux, Philippe, Bordigoni, Pierre, and Gandemer, Virginie

Published
2015
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167. Hydroxyurea does not affect the spermatogonial pool in prepubertal patients with sickle cell disease

Author

Gille, Anne-Sophie, Pondarré, Corinne, Dalle, Jean-Hugues, Bernaudin, Françoise, Chalas, Céline, Fahd, Mony, Jean, Camille, Lezeau, Harry, Riou, Lydia, Drouineaud, Véronique, Paye-Jaouen, Annabel, Kamdem, Annie, Neven, Bénédicte, Arnaud, Cécile, Azarnoush, Saba, Yakouben, Karima, Sarnacki, Sabine, de Montalembert, Mariane, Comperat, Eva Maria, Lenaour, Gilles, Sibony, Mathilde, Dhédin, Nathalie, Vaiman, Daniel, Wolf, Jean-Philippe, Patrat, Catherine, Fouchet, Pierre, Poirot, Catherine, and Barraud-Lange, Virginie

Published
2021
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168. Upfront unrelated donor hematopoietic stem cell transplantation in patients with idiopathic aplastic anemia: A retrospective study of the Severe Aplastic Anemia Working Party of European Bone Marrow Transplantation

Author

Petit, Audrey Françoise, primary, Kulasekararaj, Austin G., additional, Eikema, Dirk‐Jan, additional, Maschan, Alexey, additional, Adjaoud, Dalila, additional, Kulagin, Alexander, additional, Grassi, Anna, additional, Fagioli, Franca, additional, Griskevicius, Laimonas, additional, Snowden, John A., additional, Johansson, Jan‐Erik J., additional, Dalle, Jean‐Hugues, additional, Byrne, Jenny, additional, Risitano, Antonio M., additional, Peffault de Latour, Régis, additional, and Dufour, Carlo, additional

Published
2021
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169. Post-Transplantation Cyclophosphamide for Gvhd Prophylaxis in Related and Unrelated Allogeneic Hematopoietic Cell Transplantation: Study from the SFGM-TC Registry

Author

Michallet, Mauricette, primary, Coman, Tereza, additional, Morisset, Stephane, additional, Sobh, Mohamad, additional, Devillier, Raynier, additional, Yakoub-Agha, Ibrahim, additional, Forcade, Edouard, additional, Maertens, Johan A., additional, Bourhis, Jean-Henri, additional, Poiré, Xavier, additional, Labussière, Hélène, additional, Chevallier, Patrice, additional, Chalandon, Yves, additional, Fegueux, Nathalie, additional, Huynh, Anne, additional, Dulery, Remy, additional, Nguyen Quoc, Stéphanie, additional, Dalle, Jean-Hugues, additional, Bulabois, Claude-Eric, additional, Mear, Jean-Baptiste, additional, Rubio, Marie-Thérèse, additional, Raus, Nicole, additional, and Robin, Marie, additional

Published
2021
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170. HLA-Matched Related Hematopoietic Stem Cell Transplantation in Adolescents and Adults with Sickle Cell Disease: Comparison of Myeloablative Versus Non Myeloablative Approaches. Report from the Société Francophone De Greffe De Moelle Et De Thérapie Cellulaire

Author

Dhedin, Nathalie, primary, Chevillon, Florian, additional, Castelle, Martin, additional, Lavoipierre, Virginie, additional, Dalle, Jean-Hugues, additional, Vasseur, Loïc, additional, Joseph, Laure, additional, Beckerich, Florence, additional, Buchbinder, Nimrod, additional, Coman, Tereza, additional, Garban, Frederic, additional, Ferster, Alina, additional, Boissel, Nicolas, additional, Nguyen Quoc, Stephanie, additional, Arlet, Jean-Benoit, additional, and Pondarré, Corinne, additional

Published
2021
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171. Outcome of Allogeneic HSCT after Chemo-Based Conditioning in Infants with Acute Myeloid Leukemia in First Complete Remission: A Multicenter EBMT-PDWP Study

Author

Willasch, Andre Manfred, primary, Peters, Christina, additional, Balduzzi, Adriana, additional, Dalle, Jean-Hugues, additional, Zecca, Marco, additional, Al-Seraihy, Amal, additional, Locatelli, Franco, additional, Bertrand, Yves, additional, Robinson, Stephen, additional, OBrien, Tracey, additional, Toren, Amos, additional, Vujic, Dragana S., additional, Bay, Jacques-Olivier, additional, Jubert, Charlotte, additional, Faraci, Maura, additional, Rialland, Fanny, additional, Kitra-Roussou, Vassiliki, additional, Michel, Gerard, additional, Menconi, Mariacristina, additional, Fagioli, Franca, additional, Ziino, Ottavio, additional, Sundin, Mikael, additional, Pochon, Cecile, additional, Veys, Paul, additional, Moraleda, Jose Maria, additional, Biffi, Alessandra, additional, Dalissier, Arnaud, additional, Corbacioglu, Selim, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, and Bader, Peter, additional

Published
2021
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172. Final Long-Term Results from the Defifrance Registry Study: Efficacy and Safety of Defibrotide for the Treatment of Severe/Very Severe Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation

Author

Mohty, Mohamad, primary, Blaise, Didier, additional, Peffault De Latour, Regis, additional, Labopin, Myriam, additional, Detrait, Marie, additional, Girault, Stephane, additional, Huynh, Anne, additional, Labussière-Wallet, Hélène, additional, Lamy, Thierry, additional, Lebon, Delphine, additional, Maury, Sébastien, additional, Renard, Cecile, additional, Asubonteng, Kobby, additional, Delaval, Floriane, additional, Yakoub-Agha, Ibrahim, additional, and Dalle, Jean-Hugues, additional

Published
2021
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173. Clonal Hematopoiesis Driven By MDM4 Amplification Defines a Canonical Route Towards Secondary MDS/AML in Fanconi Anemia Patients

Author

Sebert, Marie, primary, Gachet, Stéphanie, additional, Leblanc, Thierry, additional, Rousseau, Alix, additional, Bluteau, Olivier, additional, KIM, Rathana, additional, Benabelali, Raouf, additional, Sicre de Fontbrune, Flore, additional, Maillard, Loïc, additional, Fedronie, Carèle, additional, Vasquez, Nadia, additional, Bertrand, Yves, additional, Dalle, Jean-Hugues, additional, Sigaux, Francois, additional, Chevret, Sylvie, additional, Socie, Gerard, additional, de Thé, Hugues, additional, Antoniewski, Christophe, additional, Bluteau, Dominique, additional, Peffault De Latour, Regis, additional, and Soulier, Jean, additional

Published
2021
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174. Hematopoietic Stem Cell Transplantation for Acute Lymphoblastic Leukemia: Why Do Adolescents and Young Adults Outcomes Differ from Those of Children? a Study on Behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)

Author

Grain, Audrey, primary, Rialland, Fanny, additional, Chevallier, Patrice, additional, Blin, Nicolas, additional, Dalle, Jean-Hugues, additional, Michel, Gerard, additional, Dhedin, Nathalie, additional, Peffault De Latour, Regis, additional, Pochon, Cecile, additional, yakoub Agha, Ibrahim, additional, Bertrand, Yves, additional, Sirvent, Anne, additional, Jubert, Charlotte, additional, Forcade, Edouard, additional, Berceanu, Anna, additional, Gandemer, Virginie, additional, Schneider, Pascale, additional, Bay, Jacques-Olivier, additional, Rohrlich, Pierre Simon, additional, Brissot, Eolia, additional, Paillard, Catherine, additional, Plantaz, Dominique, additional, Nguyen Quoc, Stephanie, additional, Gonzales, Fanny, additional, Maillard, Natacha, additional, Planche, Lucie, additional, and Baruchel, Andre, additional

Published
2021
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175. Impact of COVID-19 pandemic on the use and release of cord blood units facilitated by the French Cord Blood Banks Network: on behalf of the Agency of Biomedicine, Eurocord and the French Society of Bone Marrow Transplant and Cell Therapy (SFGM-TC)

Author

Rafii, Hanadi, primary, Ionescu, Irina, additional, Ruggeri, Annalisa, additional, Garnier, Federico, additional, Ballot, Caroline, additional, Bensoussan, Danièle, additional, Chabannon, Christian, additional, Dazey, Bernard, additional, De Vos, John, additional, Gautier, Eric, additional, Giraud, Christine, additional, Larghero, Jérome, additional, Cras, Audrey, additional, Mialou, Valérie, additional, Persoons, Virginie, additional, Pouthier, Fabienne, additional, Thibert, Jean-Baptiste, additional, Dalle, Jean-Hugues, additional, Michel, Gerard, additional, Sinayoko, Mahamadou, additional, Kenzey, Chantal, additional, Volt, Fernanda, additional, Rocha, Vanderson, additional, Bay, Jacques-Olivier, additional, Rubio, Marie-Thérèse, additional, Robin, Marie, additional, Faucher, Catherine, additional, Marry, Evelyne, additional, and Gluckman, Eliane, additional

Published
2021
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176. Evaluation of two prognostic scoring systems for respiratory syncytial virus infection in a French multicentre cohort of allogeneic hematopoietic stem cell transplant recipients

Author

Houist, Anne-Laure, primary, Bondeelle, Louise, additional, Cassonnet, Stephane, additional, Salmona, Maud, additional, Le Goff, Jérôme, additional, Peffault De Latour, Regis, additional, Rivière, Frederic, additional, Soler, Charles, additional, Houdouin, Véronique, additional, Dalle, Jean-Hugues, additional, Robin, Christine, additional, Fourati, Slim, additional, Griscelli, Franck, additional, Coman, Tereza, additional, Chevret, Sylvie, additional, and Bergeron, Anne, additional

Published
2021
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177. Improved outcome in children compared to adolescents and young adults after allogeneic hematopoietic stem cell transplant for acute myeloid leukemia: a retrospective study from the Francophone Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC)

Author

Pochon, Cécile, primary, Detrait, Marie, additional, Dalle, Jean-Hugues, additional, Michel, Gérard, additional, Dhédin, Nathalie, additional, Chalandon, Yves, additional, Brissot, Eolia, additional, Forcade, Edouard, additional, Sirvent, Anne, additional, Izzadifar-Legrand, Faezeh, additional, Michallet, Mauricette, additional, Renard, Cécile, additional, Yakoub-Agha, Ibrahim, additional, Gonzales, Fanny, additional, Bay, Jacques-Olivier, additional, Kanold, Justyna, additional, Cornillon, Jérome, additional, Bulabois, Claude Eric, additional, Angoso, Marie, additional, Nguyen, Stéphanie, additional, Balza, Marie, additional, Chevallier, Patrice, additional, Rialland, Fanny, additional, Bazarbachi, Ali, additional, Beguin, Yves, additional, Huynh, Anne, additional, Ménard, Anne-Lise, additional, Schneider, Pascale, additional, Neven, Bénédicte, additional, Paillard, Catherine, additional, Raus, Nicole, additional, Albuisson, Eliane, additional, Remen, Thomas, additional, and Rubio, Marie-Thérèse, additional

Published
2021
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178. Quantification du pool de spermatogonies dans le tissu testiculaire de patients drépanocytaires prépubères : analyse immunohistologique de l’impact de l’exposition à l’hydroxyurée

Author

Gille, Anne-Sophie, primary, Pondarre, Corinne, additional, Dalle, Jean-Hugues, additional, Bernaudin, Françoise, additional, Chalas, Céline, additional, Fahd, Mony, additional, Jean, Camille, additional, Lezeau, Harry, additional, Riou, Lydia, additional, Drouineaud, Véronique, additional, Paye-Jaouen, Annabel, additional, Kamdem, Annie, additional, Neven, Bénédicte, additional, Arnaud, Cécile, additional, Azarnoush, Saba, additional, Yakouben, Karima, additional, Sarnacki, Sabine, additional, De Montalembert, Mariane, additional, Comperat, Eva Maria, additional, Le Naour, Gilles, additional, Sibony, Mathilde, additional, Dhédin, Nathalie, additional, Vaiman, Daniel, additional, Wolf, Jean-Philippe, additional, Patrat, Catherine, additional, Fouchet, Pierre, additional, Poirot, Catherine, additional, and Barraud-Lange, Virginie, additional

Published
2021
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179. Cohort Profile: The French Childhood Cancer Survivor Study For Leukaemia (LEA Cohort)

Author

Berbis, Julie, Michel, Gérard, Baruchel, André, Bertrand, Yves, Chastagner, Pascal, Demeocq, François, Kanold, Justyna, Leverger, Guy, Plantaz, Dominique, Poirée, Marilyne, Stephan, Jean-Louis, Auquier, Pascal, Contet, Audrey, Dalle, Jean-Hugues, Ducassou, Stéphane, Gandemer, Virginie, Lutz, Patrick, Sirvent, Nicolas, Tabone, Marie-Dominique, and Thouvenin-Doulet, Sandrine

Published
2015
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182. Clinical value of pre-transplant minimal residual disease in childhood lymphoblastic leukaemia: the results of the French minimal residual disease-guided protocol

Author

Gandemer, Virginie, Pochon, Cécile, Oger, Emmanuel, Dalle, Jean-Hugues H., Michel, Gérard, Schmitt, Claudine, de Berranger, Eva, Galambrun, Claire, Cavé, Hélène, Cayuela, Jean-Michel, Grardel, Nathalie, Macintyre, Elizabeth, Margueritte, Geneviève, Méchinaud, Françoise, Rorhlich, Pierre, Lutz, Patrick, Demeocq, François, Schneider, Pascale, Plantaz, Dominique, Poirée, Marilyne, and Bordigoni, Pierre

Published
2014
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183. Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia

Author

Tabone, Marie-Dominique, Kolta, Sami, Auquier, Pascal, Vercasson, Camille, Chastagner, Pascal, Kanold, Justyna, Rohrlich, Pierre-Simon, Bertrand, Yves, Baruchel, André, Plantaz, Dominique, Gandemer, Virginie, Ducassou, Stéphane, Petit, Arnaud, Paillard, Catherine, Leverger, Guy, Dalle, Jean-Hugues, Berbis, Julie, Roux, Christian, and Michel, Gérard

Subjects
lcsh:RC633-647.5, lcsh:Diseases of the blood and blood-forming organs, Article
Abstract

This prospective study aimed to analyze determinants that can influence bone mineral density evolution in childhood acute leukemia survivors. Patients included were selected from the long-term follow-up LEA cohort and had dual energy radiograph absorptiometry scan between 10 and 18 years and after the age of 18. All scans were centrally reviewed. Bone mineral density was measured at the lumbar spine, femoral neck, total hip, and whole body, and expressed as z-score. Eighty-nine patients (female 39, lymphoblastic leukemia 68, relapse 25, hematopoietic stem cell transplantation 44, and mean age 15.4 and 20.1 years at the first and second scans, respectively) were studied. The first and second scan z-scores were significantly correlated (P < 10−3). Mean femoral neck and total hip z-scores improved significantly between the first and second scans, whereas no significant evolution occurred at the lumbar spine and whole-body level. On the second evaluation, 14.6% of patients had z-score

Published
2021
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184. ABO incompatibile graft management in pediatric transplantation

Author

Balduzzi, Adriana, Bönig, Halvard, Jarisch, Andrea, Nava, Tiago, Ansari Djaberi, Marc Georges, Cattoni, Alessandro, Prunotto, Giulia, Lucchini, Giovanna, Krivan, Gergely, Matic, Toni, Kalwak, Krzyzstof, Yesilipek, Akif, Ifversen, Marianne, Svec, Peter, Buechner, Jochen, Vettenranta, Kim, Meisel, Roland, Lawitschka, Anita, Peters, Christina, Gibson, Brenda, Dalissier, Arnaud, Corbacioglu, Selim, Willasch, André, Dalle, Jean-Hugues, Bader, Peter, EBMT Pediatric Diseases Working Party, Balduzzi, A, Bönig, H, Järisch, A, Nava, T, Ansari, M, Cattoni, A, Prunotto, G, Lucchini, G, Krivan, G, Matic, T, Kalwak, K, Yesilipek, A, Ifversen, M, Svec, P, Büchner, J, Vettenranta, K, Meisel, R, Lawitschka, A, Peters, C, Gibson, B, Dalissier, A, Corbacioglu, S, Willasch, A, Dalle, J, Bader, P, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital, and Helsinki University Hospital Area

Subjects
medicine.medical_specialty, Erythrocytes, BONE-MARROW, medicine.medical_treatment, Pure red cell aplasia, Hematopoietic stem cell transplantation, Hemolysis, Isohemagglutinin, ABO Blood-Group System, ABO incompatibility, 03 medical and health sciences, 0302 clinical medicine, TRANSFUSION, 3123 Gynaecology and paediatrics, ABO blood group system, medicine, Humans, Child, Bone Marrow Transplantation, Transplantation, ddc:618, PLASMA, business.industry, Hematology, medicine.disease, 3. Good health, Surgery, REDUCTION, medicine.anatomical_structure, pediatric, Tolerability, Blood Group Incompatibility, 030220 oncology & carcinogenesis, hematopoietic stem cell transplantation, Erythropoiesis, PROGENITOR-CELL TRANSPLANTATION, Bone marrow, DEPLETION, business, 030215 immunology
Abstract

Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor's RBCs have antigens missing on the recipient's cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.

Published
2021

185. Discontinuation of Imatinib in Children with Chronic Myeloid Leukemia: A Study from the International Registry of Childhood CML

Author

Millot, Frédéric, primary, Suttorp, Meinolf, additional, Ragot, Stéphanie, additional, Leverger, Guy, additional, Dalle, Jean-Hugues, additional, Thomas, Caroline, additional, Cheikh, Nathalie, additional, Nelken, Brigitte, additional, Poirée, Marilyne, additional, Plat, Geneviève, additional, Versluys, Birgitta, additional, Lausen, Birgitte, additional, and Borisevich, Marina, additional

Published
2021
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186. Supportive Care During Pediatric Hematopoietic Stem Cell Transplantation: Prevention of Infections. A Report From Workshops on Supportive Care of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Ifversen, Marianne, primary, Meisel, Roland, additional, Sedlacek, Petr, additional, Kalwak, Krzysztof, additional, Sisinni, Luisa, additional, Hutt, Daphna, additional, Lehrnbecher, Thomas, additional, Balduzzi, Adriana, additional, Diesch, Tamara, additional, Jarisch, Andrea, additional, Güngör, Tayfun, additional, Stein, Jerry, additional, Yaniv, Isaac, additional, Bonig, Halvard, additional, Kuhlen, Michaela, additional, Ansari, Marc, additional, Nava, Tiago, additional, Dalle, Jean-Hugues, additional, Diaz-de-Heredia, Cristina, additional, Trigoso, Eugenia, additional, Falkenberg, Ulrike, additional, Hartmann, Mihaela, additional, Deiana, Marco, additional, Canesi, Marta, additional, Broggi, Chiara, additional, Bertaina, Alice, additional, Gibson, Brenda, additional, Krivan, Gergely, additional, Vettenranta, Kim, additional, Matic, Toni, additional, Buechner, Jochen, additional, Lawitschka, Anita, additional, Peters, Christina, additional, Yesilipek, Akif, additional, Yalçin, Koray, additional, Lucchini, Giovanna, additional, Bakhtiar, Shahrzad, additional, Turkiewicz, Dominik, additional, Niinimäki, Riitta, additional, Wachowiak, Jacek, additional, Cesaro, Simone, additional, Dalissier, Arnaud, additional, Corbacioglu, Selim, additional, Willasch, Andre Manfred, additional, and Bader, Peter, additional

Published
2021
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187. Improved Outcome in Young Children Compared to Adolescents and Adults After Allogeneic Hematopoietic Stem Cell Transplant for Acute Myeloid Leukemia: a Retrospective Study From Francophone Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC) (SFGM-TC)

Author

POCHON, Cécile, primary, Detrait, Marie, additional, Dalle, Jean-Hugues, additional, Michel, Gérard, additional, Dhédin, Nathalie, additional, Chalandon, Yves, additional, Brissot, Eolia, additional, Forcade, Edouard, additional, Sirvent, Anne, additional, Izzadifar-Legrand, Faezeh, additional, Michallet, Mauricette, additional, Renard, Cécile, additional, Yakoub-Agha, Ibrahim, additional, Gonzales, Fanny, additional, Bay, Jacques- Olivier, additional, Kanold, Justyna, additional, Cornillon, Jérome, additional, Bulabois, Claude Eric, additional, Angoso, Marie, additional, Nguyen, Stéphanie, additional, Labussière-Wallet, Hélène, additional, Chevallier, Patrice, additional, Rialland, Fanny, additional, Bazarbachi, Ali, additional, Beguin, Yves, additional, Huynh, Anne, additional, Ménard, Anne-Lise, additional, Schneider, Pascale, additional, Neven, Bénédicte, additional, Paillard, Catherine, additional, Raus, Nicole, additional, Albuisson, Eliane, additional, Remen, Thomas, additional, and Rubio, Marie-Thérèse, additional

Published
2021
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188. Leukaemic transformation in a 10‐year‐old girl with SRP54 congenital neutropenia.

Author

Calvo, Charlotte, Lainey, Elodie, Caye, Aurélie, Cuccuini, Wendy, Fenneteau, Odile, Yakouben, Karima, Bellanné‐Chantelot, Christine, Baruchel, André, Dalle, Jean‐Hugues, and Leblanc, Thierry

Subjects
EXOCRINE pancreatic insufficiency, NEUTROPENIA, CORD blood transplantation, HEMATOPOIETIC stem cell transplantation, SOMATIC mutation
Abstract

Screening for G-CSF receptor mutations in patients with secondary myeloid or lymphoid transformation of severe congenital neutropenia. In 2018, Bellanné-Chantelot et al. first reported patients with I SRP54 i mutations presenting with severe congenital neutropenia (SCN) and extra-haematopoietic organ dysfunctions close to Shwachman-Diamond syndrome (SDS) phenotypes.1,2 I SRP54 i mutations have been shown as the second most common cause of SCN in the French neutropenia registry.2 Our female patient was diagnosed with SCN at the age of five weeks: full blood cell counts showed profound neutropenia at 100 cells/ l with relative monocytosis at 1400 cells/ l. Systematic screening for immune deficiency and anti-neutrophil autoantibodies was negative. Granulocyte colony-stimulating factor receptor mutations in a patient with acute lymphoblastic leukemia secondary to severe congenital neutropenia. [Extracted from the article]

Published
2022
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189. Allogeneic Hematopoietic Stem Cell Transplantation for BCR/ABL1-Negative Myeloproliferative Neoplasms in Children - Retrospective Report on Behalf of I-BFM SCT Committee and EBMT Pediatric Diseases WP

Author

Patrick, Katharine, Gruhn, Bernd, Corbacioglu, Selim, Kupesiz, Alphan, Balduzzi, Adriana, Al-Seraihy, Amal, Wynn, Robert, Veys, Paul, Stepensky, Polina, Robinson, Stephen, Locatelli, Franco, Dalissier, Arnaud, Galimard, Jacques-Emmanuel, Wachowiak, Jacek, Tbakhi, Abdelghani, Diaz, Miguel Angel, Socie, Gerard, Sedlacek, Petr, Abboud, Miguel, Beelen, Dietrich, Krivan, Gergely, ÜNAL, ALİ, Bodova, Ivana, Freycon, Claire, Dalle, Jean-Hugues, Jubert, Charlotte, Ferster, Alina, Ifversen, Marianne, and Hamladji, Rose-Marie

Published
2020

190. Adoptive immunotherapy of refractory viral infections after allogeneic HSCT: An academic network framing the use of ATMP under hospital exemption

Author

Wang, Yingying, De Carvalho-Bittencourt, Marcelo, Pierre, Typhaine, Gauthier, Melanie, Decot, Veronique, Clement, Laurence, Pochon, Cecile, Bilger, Karine, Larghero, Jerome, Rouard, Hélene, Legendre, Anne, Petitpain, Nadine, Dalle, Jean Hugues, Bensoussan, Danièle, unité de thérapie cellulaire et Tissus (UTCT), and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

192. Moderate Incidence but Striking Correlation with TBI of Secondary Malignancies after HSCT in Children with ALL: Long-Term Follow-up from the Prospective International BFM- and Forum-Trials

Author

Lawitschka, Anita, Dalle, Jean-Hugues, Pötschger, Ulrike, Arnardottir, Helga, Sedlacek, Petr, Büchner, Jochen, Ifversen, Marianne, Svec, Peter, Stein, Jerry, Güngör, Tayfun, Toporski, Jacek, Díaz De Heredia, Cristina, Bierings, Marc, Meisel, Roland, Ansari, Marc, Balduzzi, Adriana, Locatelli, Franco, Peters, Christina, and Bader, Peter

Published
2023
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193. Low Disease Burden Pre-CAR-T Cell Therapy for Children and AYA with B-ALL Is Associated with an Impaired Outcome When Obtained through Intensification of the Bridging Therapy

Author

Lecornec, Nicolas, Dourthe, Marie-Emilie, Rabian, Florence, Yakouben, Karima, Chevillon, Florian, Chaillou, Delphine, Caillat-Zucman, Sophie, Cuffel, Alexis, Lesprit, Emmanuelle, Arnould, Anne, Naudin, Jérome, Roupret-Serzec, Julie, Parquet, Nathalie, Brignier, Anne, Guerin-El Khourouj, Valerie, Lainey, Elodie, Caye-Eude, Aurélie, Arfeuille, Chloe, Clappier, Emmanuelle, Mathis, Stéphanie, Chaix, Marie-Laure, Azoulay, Elie, Dalle, Jean-Hugues, Madelaine, Isabelle, Larghero, Jerome, Boissel, Nicolas, and Baruchel, André

Published
2023
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194. Outcomes and Late Complications after Umbilical Cord Blood Transplantation for Fanconi Anemia: A Study on Behalf of Eurocord and Severe Aplastic Anemia Working Party - EBMT

Author

Rafii, Hanadi, Peffault De Latour, Regis, Bierings, Marc, Dalle, Jean-Hugues, Ayas, Mouhab F., Rihani, Rawad, Lanino, Edoardo, Kenzey, Chantal, Volt, Fernanda, Rivera Franco, Monica M. M, Cappelli, Barbara, Scigliuolo, Graziana, Rocha, Vanderson, Ruggeri, Annalisa, Risitano, Antonio M, and Gluckman, Éliane

Published
2023
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195. Changes in the Immunogenetic Landscape with the Age of Disease Onset in Acquired Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria: An Analysis of a Cohort of Adult and Pediatric Patients from the French National Reference Center for Aplastic Anemia

Author

Allain, Vincent, Villemonteix, Juliette, Leblanc, Thierry, Chevillon, Florian, Fortier, Catherine, Fahd, Mony, Dalle, Jean-Hugues, Socié, Gerard, Peffault De Latour, Regis, Caillat-Zucman, Sophie, and Sicre De Fontbrune, Flore

Published
2023
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196. Outcome of Children with B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) with Hypodiploidy or BCR-ABL1 Fusion Given Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): Results from the Prospective Forum Study

Author

Buechner, Jochen, Poetschger, Ulrike, Kurzmann, Paulina, Bader, Peter, Dalle, Jean-Hugues, Yesilipek, Akif, Pichler, Herbert, Palma, Julia, Staciuk, Raquel, Sedlacek, Petr, Krivan, Gergely, Ifversen, Marianne, Güngör, Tayfun, Kitra Rousou, Vassiliki, Kalwak, Krzysztof, Toporski, Jacek, Shaw, Peter J., Renard, Marleen, Díaz De Heredia, Cristina, Matic, Toni, Bierings, Marc, Svec, Peter, Meisel, Roland, Balduzzi, Adriana, Locatelli, Franco, Peters, Christina, and Stein, Jerry

Published
2023
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197. Outcomes for Children with High Risk Acute Myeloid Leukemia on the Myechild 01 International Phase III Clinical Trial

Author

Moore, Andrew, Maycock, Shanna, Leverger, Guy, Smith, Owen, Baruchel, Andre, Bertrand, Yves, Ancliff, Phil, Heaney, Nicholas, Shenton, Geoff, Petit, Arnaud, Bourquin, Jean-Pierre, Jackson, Aimee, Lawson, Anna, Amrolia, Persis, Michel, Gerard, Dalle, Jean-Hugues, Ansari, Marc, Lapillonne, Hélène, Dillon, Richard, Jovanovic, Jelena, Roumier, Christophe, Duployez, Nicolas, Harrison, Christine, Schwab, Claire, Cuccuini, Wendy, Lafage-Pochitaloff, Marina, Vyas, Paresh, Hirsch, Pierre, Veal, Gareth, Kearns, Pam, and Gibson, Brenda

Published
2023
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198. Chronic Graft-Versus-Host Disease in Long-Term Survivors of Childhood Leukemia

Author

Saultier, Paul, Michel, Gerard, Sirvent, Anne, Halfon-Domenech, Carine, Tabone, Marie-Dominique, Leverger, Guy, Baruchel, Andre, Pochon, Cecile, Paillard, Catherine, Ducassou, Stephane, Poiree, Marilyne, Plantaz, Dominique, Kanold, Justyna, Gandemer, Virginie, Sirvent, Nicolas, Raus, Nicole, Thouvenin, Sandrine, Berbis, Julie, Auquier, Pascal, and Dalle, Jean-Hugues

Published
2023
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199. Similar Overall Survival and Event-Free Survival for Patients Under or over the Age of 14 Years, but More Chronic Graft Versus Host Disease and Non-Relapse Mortality in the “Older” Patients

Author

Peters, Dr., Bader, Peter, Pötschger, Ulrike, Yesilipek, M. Akif, Pichler, Herbert, Locatelli, Franco, Staciuk, Raquel, Balduzzi, Adriana, Krivan, Gergely, Ifversen, Marianne, Díaz De Heredia, Cristina, Bierings, Marc, Wachowiak, Jacek, and Dalle, Jean-Hugues

Published
2023
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200. Comparable Outcome after Busulfan- or Treosulfan-Based Conditioning Regimen in Children Above 4 Years of Age with ALL Undergoing Allogeneic HSCT. Results from the Prospective International Forum-Trial

Author

Kalwak, Krzysztof, Bader, Peter, Dalle, Jean-Hugues, Sedlacek, Petr, Buechner, Jochen, Ifversen, Marianne, Svec, Peter, Stein, Jerry, Güngör, Tayfun, Toporski, Jacek, Diaz De Heredia, Cristina, Bierings, Marc, Meisel, Roland, Ansari, Marc, Balduzzi, Adriana, Poetschger, Ulrike, Peters, Dr., and Locatelli, Franco

Published
2023
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