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151. Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study

Author: Navarrete-Muñoz, Eva-Maria, primary, Vioque, Jesus, additional, Toledo, Estefanía, additional, Oncina-Canovas, Alejando, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, López-Miranda, José, additional, Bueno-Cavanillas, Aurora, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Sánchez, Vicente Martín, additional, Vidal, Josep, additional, de Cos Blanco, Ana Isabel, additional, Ros, Emili, additional, Diez-Espino, Javier, additional, Babio, Nancy, additional, Fernandez-Carrion, Rebeca, additional, Castañer, Olga, additional, Colom, Antoni, additional, Compañ-Gabucio, Laura, additional, Lete, Itziar Salaverria, additional, Crespo-Oliva, Edelys, additional, Abete, Itziar, additional, Tomaino, Laura, additional, Casas, Rosa, additional, Fernandez-Garcia, José Carlos, additional, Santos-Lozano, José Manuel, additional, Sarasa, Iziar, additional, Gámez, José M., additional, Garcia-Rios, José M. Antonio, additional, Martín-Pelaez, Sandra, additional, Ruiz-Canela, Miguel, additional, Díaz-López, Andrés, additional, Martinez-Lacruz, Raul, additional, Zomeño, Maria Dolors, additional, Rayó, Elena, additional, Sellés, Cristina Gisbert, additional, Canudas, Silvia, additional, Goday, Albert, additional, and García-de-la-Hera, Manoli, additional
Published: 2020
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152. Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients

Author: Martinez-Urbistondo, Maria, primary, Mora-Vargas, Alberto, additional, Expósito-Palomo, Esther, additional, Castejón, Raquel, additional, Citores, M. Jesús, additional, Rosado, Silvia, additional, de Mendoza, Carmen, additional, Baños, Isolina, additional, Fernández-Cruz, Ana, additional, Daimiel, Lidia, additional, San-Cristóbal, Rodrigo, additional, Vargas, Juan Antonio, additional, and Martinez, J. Alfredo, additional
Published: 2020
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153. Antioxidant Lifestyle, Co-Morbidities and Quality of Life Empowerment Concerning Liver Fibrosis

Author: Martinez-Urbistondo, Diego, primary, Suarez del Villar, Rafael, additional, Argemí, Josepmaria, additional, Daimiel, Lidia, additional, Ramos-López, Omar, additional, San-Cristobal, Rodrigo, additional, Villares, Paula, additional, and Martinez, Jose Alfredo, additional
Published: 2020
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154. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Author: Díaz-López, Andrés, primary, Becerra-Tomás, Nerea, additional, Ruiz, Verónica, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Corella, Dolores, additional, Fíto, Montse, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Martínez, J.Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, López-Miranda, José, additional, Ibañez, Naomi Cano, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Paz, Jose Antonio de la, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ruiz-Canela, Miguel, additional, Bulló, Mònica, additional, Sorlí, José V, additional, Goday, Albert, additional, Fiol, Miquel, additional, García-de-la-Hera, Manoli, additional, Sierra, Lucas Tojal, additional, Pérez-Farinós, Napoleón, additional, Zulet, Maria Angeles, additional, Sánchez-Villegas, Almudena, additional, Sacanella, Emilio, additional, Fernández-García, José Carlos, additional, Santos-Lozano, José Manuel, additional, Gimenez-Gracia, Miquel, additional, Bibiloni, Maria del Mar, additional, Diez-Espino, Javier, additional, Ortega-Azorin, Carolina, additional, Castañer, Olga, additional, Morey, Marga, additional, Torres-Collado, Laura, additional, Sanchez, Carolina Sorto, additional, Muñoz, Miguel Ángel, additional, Ros, Emilio, additional, Martínez-González, Miguel A, additional, and Salas-Salvadó, Jordi, additional
Published: 2020
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155. Dietary Quality Changes According to the Preceding Maximum Weight: A Longitudinal Analysis in the PREDIMED-Plus Randomized Trial

Author: Bouzas, Cristina, primary, Bibiloni, Maria del Mar, additional, Garcia, Silvia, additional, Mateos, David, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Lopez-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Micó-Pérez, Rafael M., additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Ortíz-Ramos, María, additional, Altés-Boronat, Andreu, additional, Luca, Bogdana L., additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Sayon-Orea, Carmen, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Castañer, Olga, additional, Abete, Itziar, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Bernabé-Casanova, Andrea, additional, Martin-Padillo, Marian, additional, Garcia-Rios, Antonio, additional, Castro-Barquero, Sara, additional, Fernández-García, José Carlos, additional, Santos-Lozano, José Manuel, additional, Fernandez-Lazaro, Cesar I., additional, Hernández-Alonso, Pablo, additional, Saiz, Carmen, additional, Zomeño, Maria Dolors, additional, Zulet, Maria Angeles, additional, Belló-Mora, Maria C., additional, Basterra-Gortari, F. Javier, additional, Canudas, Silvia, additional, Goday, Albert, additional, and Tur, Josep A., additional
Published: 2020
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156. Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome

Author: Bullón-Vela, Vanessa, primary, Abete, Itziar, additional, Zulet, Maria Angeles, additional, Xu, Yifan, additional, Martínez-González, Miguel A., additional, Sayón-Orea, Carmen, additional, Ruiz-Canela, Miguel, additional, Toledo, Estefanía, additional, Sánchez, Vicente Martín, additional, Estruch, Ramon, additional, Lamuela-Raventós, Rosa María, additional, Almanza-Aguilera, Enrique, additional, Fitó, Montserrat, additional, Salas-Salvadó, Jordi, additional, Díaz-López, Andrés, additional, Tinahones, Francisco J., additional, Tur, Josep A., additional, Romaguera, Dora, additional, Konieczna, Jadwiga, additional, Pintó, Xavier, additional, Daimiel, Lidia, additional, Rodriguez-Mateos, Ana, additional, and Alfredo Martínez, José, additional
Published: 2020
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157. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study

Author: Navarrete-Muñoz, Eva-Maria, primary, Vioque, Jesus, additional, Toledo, Estefanía, additional, Oncina-Canovas, Alejando, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, López-Miranda, José, additional, Bueno-Cavanillas, Aurora, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Sánchez, Vicente Martín, additional, Vidal, Josep, additional, de Cos Blanco, Ana Isabel, additional, Ros, Emili, additional, Diez-Espino, Javier, additional, Babio, Nancy, additional, Fernandez-Carrion, Rebeca, additional, Castañer, Olga, additional, Colom, Antoni, additional, Compañ-Gabucio, Laura, additional, Lete, Itziar Salaverria, additional, Crespo-Oliva, Edelys, additional, Abete, Itziar, additional, Tomaino, Laura, additional, Casas, Rosa, additional, Fernandez-Garcia, José Carlos, additional, Santos-Lozano, José Manuel, additional, Sarasa, Iziar, additional, Gámez, José M., additional, Garcia-Rios, José M. Antonio, additional, Martín-Pelaez, Sandra, additional, Ruiz-Canela, Miguel, additional, Díaz-López, Andrés, additional, Martinez-Lacruz, Raul, additional, Zomeño, Maria Dolors, additional, Rayó, Elena, additional, Sellés, Cristina Gisbert, additional, Canudas, Silvia, additional, Goday, Albert, additional, and García-de-la-Hera, Manoli, additional
Published: 2020
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158. Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

Author: Bouzas, Cristina, primary, Bibiloni, Maria del Mar, additional, Julibert, Alicia, additional, Ruiz-Canela, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Maria Dolors, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, García Ríos, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Fernandez-Lázaro, Cesar Ignacio, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Muñoz, Julia, additional, Morey, Marga, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Abete, Itziar, additional, Casañas-Quintana, Tamara, additional, Castro-Barquero, Sara, additional, Bernal-López, M. Rosa, additional, Santos-Lozano, José Manuel, additional, Galera, Ana, additional, Angullo-Martinez, Escarlata, additional, Basterra-Gortari, F. Javier, additional, Basora, Josep, additional, Saiz, Carmen, additional, Castañer, Olga, additional, Martín, Marian, additional, Notario-Barandiarán, Leyre, additional, Belló-Mora, María C., additional, Sayón-Orea, Carmen, additional, García-Gavilán, Jesús, additional, Goday, Albert, additional, and Tur, Josep A., additional
Published: 2020
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159. Impact of Phenol‐Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease

Author: Daimiel, Lidia, primary, Micó, Víctor, additional, Valls, Rosa M, additional, Pedret, Anna, additional, Motilva, María José, additional, Rubió, Laura, additional, Fitó, Montse, additional, Farrás, Marta, additional, Covas, María Isabel, additional, Solá, Rosa, additional, and Ordovás, José M., additional
Published: 2020
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160. The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Author: Marcos-Delgado, Alba, primary, Fernández-Villa, Tania, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Castañer, Olga, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J, additional, Lapetra, José, additional, Serra-Majem, J. LLuís, additional, García-Molina, Laura, additional, Tur, Josep A., additional, de Paz, José Antonio, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Babio, Nancy, additional, Gimenez-Alba, Ignacio M, additional, Toledo, Estefanía, additional, Zomeño, María Dolores, additional, Zulet, M. A., additional, Vaquero-Luna, Jessica, additional, Pérez-López, Jessica, additional, Pastor-Morel, Ana, additional, Galmes-Panades, Aina M, additional, García-Rios, Antonio, additional, Casas, Rosa, additional, Bernal-López, María Rosa, additional, Santos-Lozano, José Manuel, additional, Becerra-Tomás, Nerea, additional, Ortega-Azorin, Carolina, additional, Vázquez-Ruiz, Zenaida, additional, Pérez-Vega, Karla Alejandra, additional, Abete, Itziar, additional, Sorto-Sánchez, Carolina, additional, Palau-Galindo, Antoni, additional, Galilea-Zabalza, Iñigo, additional, Muñoz-Martínez, Júlia, additional, and Martín, Vicente, additional
Published: 2020
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161. Relationship between visceral adipose tissue and triglyceride glucose index with liver status in men and women with metabolic syndrome features: sex differences

Author: Bullón-Vela, Vanessa, primary, Abete, Itziar, additional, Tur, Josep A., additional, Konieczna, Jadwiga, additional, Romaguera, Dora, additional, Pintó, Xavier, additional, Corbella, Emili, additional, Martínez-González, Miguel A., additional, Sayón-Orea, Carmen, additional, Toledo, Estefanía, additional, Corella, Dolores, additional, Macias-Gonzalez, Manuel, additional, Tinahones, Francisco J., additional, Fitó, Montserrat, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Salas-Salvadó, Jordi, additional, Daimiel, Lidia, additional, Mascaró, Catalina M., additional, Zulet, M. Angeles, additional, and Martínez, J. Alfredo, additional
Published: 2020
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162. Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study

Author: Gallardo-Alfaro, Laura, primary, Bibiloni, Maria del Mar, additional, Mascaró, Catalina M., additional, Montemayor, Sofía, additional, Ruiz-Canela, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Fernández-García, José Carlos, additional, Lapetra, José, additional, Pintó, Xavier, additional, García Ríos, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Micó-Pérez, Rafael M., additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Fernandez-Lázaro, Cesar Ignacio, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Zomeño, María Dolors, additional, Konieczna, Jadwiga, additional, Compañ-Gabucio, Laura, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Zulet, M. Ángeles, additional, Casañas-Quintana, Tamara, additional, Castro-Barquero, Sara, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Galera, Ana, additional, Basterra-Gortari, F. Javier, additional, Basora, Josep, additional, Saiz, Carmen, additional, Pérez-Vega, Karla Alejandra, additional, Galmés-Panadés, Aina M., additional, Tercero-Maciá, Cristina, additional, Sorto-Sánchez, Carolina, additional, Sayón-Orea, Carmen, additional, García-Gavilán, Jesús, additional, Muñoz-Martínez, Júlia, additional, and Tur, Josep A., additional
Published: 2020
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163. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Author: Castro-Barquero, Sara, primary, Tresserra-Rimbau, Anna, additional, Vitelli-Storelli, Facundo, additional, Doménech, Mónica, additional, Salas-Salvadó, Jordi, additional, Martín-Sánchez, Vicente, additional, Rubín-García, María, additional, Buil-Cosiales, Pilar, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, José, additional, Serra-Majem, Luís, additional, Tinahones, Francisco, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, García-Molina, Laura, additional, Delgado-Rodriguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Cofán, Montserrat, additional, Romanos-Nanclares, Andrea, additional, Becerra-Tomas, Nerea, additional, Barragan, Rocio, additional, Castañer, Olga, additional, Konieczna, Jadwiga, additional, González-Palacios, Sandra, additional, Sorto-Sánchez, Carolina, additional, Pérez-López, Jessica, additional, Zulet, María, additional, Bautista-Castaño, Inmaculada, additional, Casas, Rosa, additional, Gómez-Perez, Ana, additional, Santos-Lozano, José, additional, Rodríguez-Sanchez, María, additional, Julibert, Alicia, additional, Martín-Calvo, Nerea, additional, Hernández-Alonso, Pablo, additional, Sorlí, José, additional, Sanllorente, Albert, additional, Galmés-Panadés, Aina, additional, Cases-Pérez, Eugenio, additional, Goicolea-Güemez, Leire, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Hernáez, Álvaro, additional, Lamuela-Raventós, Rosa, additional, and Estruch, Ramon, additional
Published: 2020
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164. Relationship of visceral adipose tissue with surrogate insulin resistance and liver markers in individuals with metabolic syndrome chronic complications

Author: Bullón-Vela, Vanessa, primary, Abete, Itziar, additional, Tur, Josep A., additional, Konieczna, Jadwiga, additional, Romaguera, Dora, additional, Pintó, Xavier, additional, Corbella, Emili, additional, Martínez-González, Miguel A., additional, Sayón-Orea, Carmen, additional, Toledo, Estefanía, additional, Corella, Dolores, additional, Macías-Gonzalez, Manuel, additional, Tinahones, Francisco J., additional, Fitó, Montserrat, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Salas-Salvadó, Jordi, additional, Daimiel, Lidia, additional, Mascaró, Catalina M., additional, Zulet, Maria Angeles, additional, and Martínez, José Alfredo, additional
Published: 2020
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165. MOESM1 of Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study

Author: Galmes-Panades, Aina, Varela-Mato, Veronica, Konieczna, Jadwiga, Wärnberg, Julia, Martínez-González, Miguel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Vioque, Jesús, Alonso-Gómez, Ángel, J. Martínez, Serra-Majem, Luís, Estruch, Ramon, Tinahones, Francisco, Lapetra, José, Pintó, Xavier, Tur, Josep, Garcia-Rios, Antonio, Riquelme-Gallego, Blanca, Gaforio, José, Matía-Martín, Pilar, Daimiel, Lidia, Pérez, Rafael Manuel Micó, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Garcia-Arellano, Ana, Díaz-López, Andrés, Asensio, Eva, Castañer, Olga, Fiol, Francisca, Mira-Castejón, Luis, Anai Moreno Rodríguez, Marín, Juan Benavente, Abete, Itziar, Tomaino, Laura, Casas, Rosa, F. Barón López, Fernández-García, José, Santos-Lozano, José, Galera, Ana, Mascaró, Catalina, Razquin, Cristina, Papandreou, Christopher, Portoles, Olga, Pérez-Vega, Karla, Fiol, Miguel, Compañ-Gabucio, Laura, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Becerra-Tomás, Nerea, Fitó, Montserrat, and Romaguera, Dora
Abstract: Additional file 1: Table S1. Associations of total inactive time with adiposity indicators and cardio-metabolic risk factors (with further adjustment for light physical activity, instead of moderate-to-vigorous physical activity). Table S2. Associations of total inactive time with adiposity indicators and cardio-metabolic risk factors (with further adjustment for light physical activity, instead of moderate-to-vigorous physical activity and waist circumference as an indicator of adiposity). Table S3. Prevalence ratio of metabolic syndrome parameters according to tertiles of sedentary time (with further adjustment for light physical activity, instead of moderate-to-vigorous physical activity). Table S4. Isotemporal substitution of inactive time (30 min/day) with sleep time and physical activity on cardio-metabolic risk.
Published: 2019
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166. Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome

Author: Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-González, Miguel A., Bulló, Mónica, Corella, Dolores, Fitó, Montse, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluís, Estruch, Ramon, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomas, Nerea, Martinez-Lacruz, Raul, Schröder, Helmut, Konieczna, Jadwiga, Garcia-de-la-Hera, Manoli, Moreno-Rodriguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, José M., Trias, Ferran, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragan, Rocio, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefanía, Castañer, Olga, Salas-Salvadó, Jordi, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-González, Miguel A., Bulló, Mónica, Corella, Dolores, Fitó, Montse, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluís, Estruch, Ramon, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomas, Nerea, Martinez-Lacruz, Raul, Schröder, Helmut, Konieczna, Jadwiga, Garcia-de-la-Hera, Manoli, Moreno-Rodriguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, José M., Trias, Ferran, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragan, Rocio, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefanía, Castañer, Olga, and Salas-Salvadó, Jordi
Abstract: Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk., Unión Europea. FP7, Instituto de Salud Carlos III (ISCIII) / FEDER, Instituto de Salud Carlos III (ISCIII) / FEDER, Instituto de Salud Carlos III (ISCIII) / FEDER, Junta de Andalucía, Generalitat Valenciana, Depto. de Medicina, Fac. de Medicina, TRUE, pub
Published: 2019

167. Dietary Diversity and Nutritional Adequacy among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Pl us Study:A Cross-Sectional Analysis

Author: Medicina, Medikuntza, Cano Ibáñez, Naomi, Gea, Alfredo, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Zomeño Blanquerna, María Dolores, Romaguera, Dora, Vioque, Jesús, Arós Borau, Luis Fernando, Warnberg, Julia, Martínez, J. Alfredo, Serra Majem, Lluís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García Ríos, Antonio, Riquelme Gallego, Blanca, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil Cosiales, Pilar, Díaz López, Andrés, Fernández Carrión, Rebeca, Fitó, Montserrat, Konieczna, Jadwiga, Notario Barandiaran, Leyre, Alonso Gómez, Ángel María, Contreras Fernández, Eugenio, Abete, Itziar, Sánchez Villegas, Almudena, Casas, Rosa, Muñoz Garach, Araceli, Santos Lozano, José Manuel, Gallardo Alfaro, Laura, Basora, Josep, Portoles, Olga, Muñoz, Miguel Ángel, Moñino, Manuel, Miralles Gisbert, Salvador, Moreno Rodríguez, Anai, Ruiz Canela, Miguel, Palau Galindo, Antoni, Pérez Vega, Karla Alejandra, Bueno Cavanillas, Aurora, Medicina, Medikuntza, Cano Ibáñez, Naomi, Gea, Alfredo, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Zomeño Blanquerna, María Dolores, Romaguera, Dora, Vioque, Jesús, Arós Borau, Luis Fernando, Warnberg, Julia, Martínez, J. Alfredo, Serra Majem, Lluís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García Ríos, Antonio, Riquelme Gallego, Blanca, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil Cosiales, Pilar, Díaz López, Andrés, Fernández Carrión, Rebeca, Fitó, Montserrat, Konieczna, Jadwiga, Notario Barandiaran, Leyre, Alonso Gómez, Ángel María, Contreras Fernández, Eugenio, Abete, Itziar, Sánchez Villegas, Almudena, Casas, Rosa, Muñoz Garach, Araceli, Santos Lozano, José Manuel, Gallardo Alfaro, Laura, Basora, Josep, Portoles, Olga, Muñoz, Miguel Ángel, Moñino, Manuel, Miralles Gisbert, Salvador, Moreno Rodríguez, Anai, Ruiz Canela, Miguel, Palau Galindo, Antoni, Pérez Vega, Karla Alejandra, and Bueno Cavanillas, Aurora
Abstract: Dietary guidelines emphasize the importance of a varied diet to provide an adequate nutrient intake. However, an older age is often associated with consumption of monotonous diets that can be nutritionally inadequate, increasing the risk for the development or progression of diet-related chronic diseases, such as metabolic syndrome (MetS). To assess the association between dietary diversity (DD) and nutrient intake adequacy and to identify demographic variables associated with DD, we cross-sectionally analyzed baseline data from the PREDIMED-Plus trial: 6587 Spanish adults aged 55-75 years, with overweight/obesity who also had MetS. An energy-adjusted dietary diversity score (DDS) was calculated using a 143-item validated semi-quantitative food frequency questionnaire (FFQ). Nutrient inadequacy was defined as an intake below 2/3 of the dietary reference intake (DRI) forat least four of 17 nutrients proposed by the Institute of Medicine (IOM). Logistic regression models were used to evaluate the association between DDS and the risk of nutritionally inadequate intakes. In the higher DDS quartile there were more women and less current smokers. Compared with subjects in the highest DDS quartile, those in the lowest DDS quartile had a higher risk of inadequate nutrient intake: odds ratio (OR) = 28.56 (95% confidence interval (CI) 20.80-39.21). When we estimated food varietyfor each of the food groups, participants in the lowest quartile had a higher risk of inadequate nutrient intake for the groups of vegetables, OR = 14.03 (95% CI 10.55-18.65), fruits OR = 11.62 (95% CI 6.81-19.81), dairy products OR = 6.54 (95% CI 4.64-9.22) and protein foods OR = 6.60 (95% CI 1.96-22.24). As DDS decreased, the risk of inadequate nutrients intake rose. Given the impact of nutrient intake adequacy on the prevention of non-communicable diseases, health policies should focus on the promotion of a healthy varied diet, specifically promoting the intake of vegetables and fruit among populati
Published: 2019

168. Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex

Author: Medicina, Medikuntza, Tresserra Rimbau, Anna, Castro Barquero, Sara, Vitelli Storelli, Facundo, Becerra Tomás, Nerea, Vázquez Ruiz, Zenaida, Díaz López, Andrés, Corella, Dolores, Castañer, Olga, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel María, Warnberg, Julia, Martínez, José Alfredo, Serra Majem, Lluís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, García Molina, Laura, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Rubín García, María, Vidal, Josep, Galdón, Alba, Ros, Emilio, Basterra Gortari, Francisco Javier, Babio, Nancy, Sorli, José Vicente, Hernáez, Álvaro, Konieczna, Jadwiga, Notario Barandiaran, Leyre, Tojal Sierra, Lucas, Pérez López, Jessica, Abete, Itziar, Álvarez Pérez, Jacqueline, Fernández García, José Carlos, Santos Lozano, José Manuel, Galera Cusí, Ana, Julibert, Alicia, Ruiz Canela, Miguel, Martinez Lacruz, Raúl, Pérez Vega, Karla Alejandra, Galmes Panades, Aina María, Pastor Polo, Concepción, Moreno Rodríguez, Anai, Gea, Alfredo, Fitó, Montserrat, Lamuela Raventos, Rosa María, Salas Salvadó, Jordi, Medicina, Medikuntza, Tresserra Rimbau, Anna, Castro Barquero, Sara, Vitelli Storelli, Facundo, Becerra Tomás, Nerea, Vázquez Ruiz, Zenaida, Díaz López, Andrés, Corella, Dolores, Castañer, Olga, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel María, Warnberg, Julia, Martínez, José Alfredo, Serra Majem, Lluís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, García Molina, Laura, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Rubín García, María, Vidal, Josep, Galdón, Alba, Ros, Emilio, Basterra Gortari, Francisco Javier, Babio, Nancy, Sorli, José Vicente, Hernáez, Álvaro, Konieczna, Jadwiga, Notario Barandiaran, Leyre, Tojal Sierra, Lucas, Pérez López, Jessica, Abete, Itziar, Álvarez Pérez, Jacqueline, Fernández García, José Carlos, Santos Lozano, José Manuel, Galera Cusí, Ana, Julibert, Alicia, Ruiz Canela, Miguel, Martinez Lacruz, Raúl, Pérez Vega, Karla Alejandra, Galmes Panades, Aina María, Pastor Polo, Concepción, Moreno Rodríguez, Anai, Gea, Alfredo, Fitó, Montserrat, Lamuela Raventos, Rosa María, and Salas Salvadó, Jordi
Abstract: This article belongs to the Special Issue Antioxidants in the Prevention and Treatment of Chronic Diseases, Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
Published: 2019

169. Nut Consumptions as a Marker of Higher Diet Quality in a Mediterranean Population at High Cardiovascular Risk

Author: Medicina, Medikuntza, Bibiloni, Maria del Mar, Julibert, Alicia, Bouzas, Cristina, Martínez González, Miguel Ángel, Corella, Dolores, Salas Salvadó, Jordi, Zomeño Blanquerna, María Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Tinahones, Francisco J., Serra Majem, Lluís, Martín, Vicente, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Ros, Emilio, Fernández Carrión, Rebeca, García Ríos, Antonio, Zulet, M. Ángeles, Orozco Beltrán, Domingo, Schröder, Helmut, Fitó, Montserrat, Bulló, Mónica, Basora, Josep, Cenoz, Juan Carlos, Díez Espino, Javier, Toledo, Estefanía, Tur, Josep A., Medicina, Medikuntza, Bibiloni, Maria del Mar, Julibert, Alicia, Bouzas, Cristina, Martínez González, Miguel Ángel, Corella, Dolores, Salas Salvadó, Jordi, Zomeño Blanquerna, María Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Tinahones, Francisco J., Serra Majem, Lluís, Martín, Vicente, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Ros, Emilio, Fernández Carrión, Rebeca, García Ríos, Antonio, Zulet, M. Ángeles, Orozco Beltrán, Domingo, Schröder, Helmut, Fitó, Montserrat, Bulló, Mónica, Basora, Josep, Cenoz, Juan Carlos, Díez Espino, Javier, Toledo, Estefanía, and Tur, Josep A.
Abstract: BACKGROUND: Nut consumption has been associated with improved nutrient adequacy and diet quality in healthy adult populations but this association has never been explored in individuals at high cardiovascular risk. OBJECTIVE: to assess the associations between consumption of nuts and nutrient adequacy and diet quality in a Mediterranean population at high cardiovascular risk. DESIGN: baseline assessment of nutritional adequacy in participants (n = 6060, men and women, with ages 55⁻75 years old, with overweight/obesity and metabolic syndrome) in the PREDIMED-PLUS primary cardiovascular prevention randomized trial. METHODS: nut intake was assessed using a validated food frequency questionnaire. Participants who reported consuming zero quantity of nuts were classified as 'non-nut consumers'. 'Nut consumers' were participants who reported consuming any quantity of nuts. Nineteen micronutrients were examined (vitamins B1, B2, B3, B6, B12, A, C, D, E and folic acid; Ca, K, P, Mg, Fe, Se, Cr, Zn, and iodine). The proportion of micronutrient inadequacy was estimated using the estimated average requirements (EAR) or adequate intake (AI) cut-points. Diet quality was also assessed using a 17-item Mediterranean dietary questionnaire (Mediterranean diet score, MDS), a carbohydrate quality index (CQI) and a fat quality index (FQI). RESULTS: eighty-two percent of participants were nut consumers (median of nut consumption 12.6 g/day; interquartile range: 6.0⁻25.2). Nut consumers were less likely to be below the EAR for vitamins A, B1, B2, B6, C, D, E, folic acid, and Ca, Mg, Se and Zn than non-nut consumers. Nut consumers were also more likely to be above the AI for K and Cr than non-nut consumers. Nut consumers had lower prevalence of inadequate micronutrient intakes, but also higher CQI, higher FQI, and better scores of adherence to the Mediterranean diet (Mediterranean diet score, MDS). CONCLUSIONS: nut consumers had better nutrient adequacy, diet quality, and adherence to the M
Published: 2019

170. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic SyndromeInterim Analysis of the PREDIMED-Plus Randomized Clinical Trial

Author: European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, Martínez-González, Miguel Ángel, European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, and Martínez-González, Miguel Ángel
Abstract: [Importance] High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on dietary changes., [Objective] To assess the effect of a nutritional and physical activity education program on dietary quality., [Design, Setting, and Participants] Preliminary exploratory interim analysis of an ongoing randomized trial. In 23 research centers in Spain, 6874 men and women aged 55 to 75 years with metabolic syndrome and no cardiovascular disease were enrolled in the trial between September 2013 and December 2016, with final data collection in March 2019., [Interventions] Participants were randomized to an intervention group that encouraged an energy-reduced Mediterranean diet, promoted physical activity, and provided behavioral support (n = 3406) or to a control group that encouraged an energy-unrestricted Mediterranean diet (n = 3468). All participants received allotments of extra-virgin olive oil (1 L/mo) and nuts (125 g/mo) for free., [Main Outcomes and Measures] The primary outcome was 12-month change in adherence based on the energy-reduced Mediterranean diet (er-MedDiet) score (range, 0-17; higher scores indicate greater adherence; minimal clinically important difference, 1 point)., [Results] Among 6874 randomized participants (mean [SD] age, 65.0 [4.9] years; 3406 [52%] men), 6583 (96%) completed the 12-month follow-up and were included in the main analysis. The mean (SD) er-MedDiet score was 8.5 (2.6) at baseline and 13.2 (2.7) at 12 months in the intervention group (increase, 4.7 [95% CI, 4.6-4.8]) and 8.6 (2.7) at baseline and 11.1 (2.8) at 12 months in the control group (increase, 2.5 [95% CI, 2.3-2.6]) (between-group difference, 2.2 [95% CI, 2.1-2.4]; P < .001)., [Conclusions and Relevance] In this preliminary analysis of an ongoing trial, an intervention that encouraged an energy-reduced Mediterranean diet and physical activity, compared with advice to follow an energy-unrestricted Mediterranean diet, resulted in a significantly greater increase in diet adherence after 12 months. Further evaluation of long-term cardiovascular effects is needed., [Trial Registration] isrctn.com Identifier: ISRCTN89898870.
Published: 2019

171. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Author: Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, and Salas-Salvadó, Jordi
Abstract: [Purpose]: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome. [Methods]:A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively., [Results]: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82–0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84–0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence., [Conclusions]: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.
Published: 2019

172. Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome

Author: Instituto de Salud Carlos III, European Commission, European Research Council, Fundación la Caixa, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundació Institut d'Investigació Sanitària Illes Balears, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-García, Miguel Ángel, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomás, Nerea, Martínez-Lacruz, Raúl, Schröder, Helmut, Konieczna, Jadwiga, García-de-la-Hera, Manoli, Moreno-Rodríguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, J. M., Trias, Ferrán, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragán, Rocío, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefania, Castañer, Olga, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Fundación la Caixa, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundació Institut d'Investigació Sanitària Illes Balears, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-García, Miguel Ángel, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomás, Nerea, Martínez-Lacruz, Raúl, Schröder, Helmut, Konieczna, Jadwiga, García-de-la-Hera, Manoli, Moreno-Rodríguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, J. M., Trias, Ferrán, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragán, Rocío, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefania, Castañer, Olga, and Salas-Salvadó, Jordi
Abstract: Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. Significant positive associations with BMI and WC were found in those participants napping ≥30 min as compared to those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk.
Published: 2019

173. Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex

Author: Tresserra-Rimbau, Anna, primary, Castro-Barquero, Sara, additional, Vitelli-Storelli, Facundo, additional, Becerra-Tomas, Nerea, additional, Vázquez-Ruiz, Zenaida, additional, Díaz-López, Andrés, additional, Corella, Dolores, additional, Castañer, Olga, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel María, additional, Wärnberg, Julia, additional, Martínez, José Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Tinahones, Francisco José, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep Antoni, additional, López-Miranda, José, additional, García-Molina, Laura, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Rubín-García, María, additional, Vidal, Josep, additional, Galdon, Alba, additional, Ros, Emilio, additional, Basterra-Gortari, Francisco Javier, additional, Babio, Nancy, additional, Sorlí, José Vicente, additional, Hernáez, Álvaro, additional, Konieczna, Jadwiga, additional, Notario-Barandiaran, Leyre, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jessica, additional, Abete, Itziar, additional, Álvarez-Pérez, Jacqueline, additional, Fernández-García, José Carlos, additional, Santos-Lozano, José Manuel, additional, Galera-Cusí, Ana, additional, Julibert, Alicia, additional, Ruiz-Canela, Miguel, additional, Martinez-Lacruz, Raul, additional, Pérez-Vega, Karla-Alejandra, additional, Galmes-Panades, Aina María, additional, Pastor-Polo, Concepción, additional, Moreno-Rodriguez, Anai, additional, Gea, Alfredo, additional, Fitó, Montserrat, additional, Lamuela-Raventós, Rosa María, additional, and Salas-Salvadó, Jordi, additional
Published: 2019
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174. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic Syndrome

Author: Sayón-Orea, Carmen, primary, Razquin, Cristina, additional, Bulló, Mónica, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, López-Miranda, José, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Sánchez, Vicente Martín, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Sorlí, José V., additional, Castañer, Olga, additional, Fiol, Miquel, additional, Navarrete-Muñoz, Eva M., additional, Arós, Fernando, additional, Gómez-Gracia, Enrique, additional, Zulet, M. Angeles, additional, Sánchez-Villegas, Almudena, additional, Casas, Rosa, additional, Bernal-López, Rosa, additional, Santos-Lozano, José M., additional, Corbella, Emili, additional, Bouzas, Cristina, additional, García-Arellano, Ana, additional, Basora, Josep, additional, Asensio, Eva M., additional, Schröder, Helmut, additional, Moñino, Manuel, additional, García de la Hera, Manoli, additional, Tojal-Sierra, Lucas, additional, Toledo, Estefanía, additional, Díaz-López, Andrés, additional, Goday, Albert, additional, Salas-Salvadó, Jordi, additional, and Martínez-González, Miguel A., additional
Published: 2019
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175. Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome

Author: Papandreou, Christopher, primary, Díaz-López, Andrés, additional, Babio, Nancy, additional, Martínez-González, Miguel A., additional, Bulló, Mónica, additional, Corella, Dolores, additional, Fitó, Montse, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, Alfredo J., additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Fernández-García, José C., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, Garcia-Rios, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Becerra-Tomas, Nerea, additional, Martinez-Lacruz, Raul, additional, Schröder, Helmut, additional, Konieczna, Jadwiga, additional, Garcia-de-la-Hera, Manoli, additional, Moreno-Rodriguez, Anai, additional, Barón-López, Javier, additional, Pérez-Farinós, Napoleón, additional, Abete, Itziar, additional, Bautista-Castaño, Inmaculada, additional, Casas, Rosa, additional, Muñoz-Garach, Araceli, additional, Santos-Lozano, José M., additional, Trias, Ferran, additional, Gallardo-Alfaro, Laura, additional, Ruiz-Canela, Miguel, additional, Barragan, Rocio, additional, Goday, Alberto, additional, Galmés-Panadés, Aina M., additional, González-Botella, Andrés, additional, Vaquero-Luna, Jessica, additional, Toledo, Estefanía, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional
Published: 2019
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176. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

Author: Julibert, Alicia, primary, Bibiloni, Maria, additional, Bouzas, Cristina, additional, Martínez-González, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Maria, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, J., additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco, additional, Lapetra, José, additional, Pintó, Xavier, additional, Lopez-Miranda, José, additional, García-Molina, Laura, additional, Gaforio, José, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Becerra-Tomás, Nerea, additional, Pórtoles, Olga, additional, Pérez-Vega, Karla, additional, Fiol, Miquel, additional, Torres-Collado, Laura, additional, Tojal-Sierra, Lucas, additional, Carabaño-Moral, Rosa, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Bernal-López, María, additional, Santos-Lozano, José, additional, Galera, Ana, additional, Ugarriza, Lucía, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Coltell, Oscar, additional, Schröder, Helmut, additional, Konieczna, Jadwiga, additional, Orozco-Beltrán, Domingo, additional, Sorto-Sánchez, Carolina, additional, Eguaras, Sonia, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Tur, Josep, additional, and Investigators, PREDIMED-PLUS, additional
Published: 2019
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177. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study

Author: Paz-Graniel, Indira, primary, Babio, Nancy, additional, Serra-Majem, Luís, additional, Vioque, Jesús, additional, Zomeño, Maria Dolores, additional, Corella, Dolores, additional, Díaz-López, Andrés, additional, Pintó, Xavier, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Daimiel, Lidia, additional, Martínez, J. Alfredo, additional, Becerra-Tomás, Nerea, additional, Navarrete-Muñoz, Eva Mª, additional, Schröder, Helmut, additional, Fernández-Carrión, Rebeca, additional, Ortiz-Andrellucchi, Adriana, additional, Corbella, Emili, additional, Riquelme-Gallego, Blanca, additional, Gallardo-Alfaro, Laura, additional, Micó, Víctor, additional, Zulet, Marian, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Ruiz-Canela, Miguel, additional, and Salas-Salvadó, Jordi, additional
Published: 2019
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178. Adherence to a priori dietary indexes and baseline prevalence of cardiovascular risk factors in the PREDIMED-Plus randomised trial

Author: Alvarez-Alvarez, Ismael, primary, Toledo, Estefanía, additional, Lecea, Oscar, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Buil-Cosiales, Pilar, additional, Zomeño, María Dolores, additional, Vioque, Jesús, additional, Martinez, J. Alfredo, additional, Konieczna, Jadwiga, additional, Barón-López, Francisco J., additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bueno-Cavanillas, Aurora, additional, Alonso-Gómez, Ángel M., additional, Tur, Josep A., additional, Tinahones, Francisco J., additional, Serra-Majem, Lluís, additional, Martín, Vicente, additional, Ortega-Calvo, Manuel, additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, González, José I., additional, Díaz-López, Andrés, additional, Paz-Graniel, Indira, additional, Muñoz, Miguel A., additional, Fito, Montse, additional, Pertusa-Martinez, Salvador, additional, Abete, Itziar, additional, García-Ríos, Antonio, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, and Martínez-González, Miguel Á., additional
Published: 2019
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179. Dietary Diversity and Nutritional Adequacy among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Author: Cano-Ibáñez, Naomi, primary, Gea, Alfredo, additional, Martínez-González, Miguel A., additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, M. Dolors, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Aros, Fernando, additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Lluis, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, García-Ríos, Antonio, additional, Riquelme-Gallego, Blanca, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Daimiel, Lidia, additional, Martín, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Díaz-López, Andrés, additional, Fernández-Carrión, Rebeca, additional, Fitó, Montserrat, additional, Konieczna, Jadwiga, additional, Notario-Barandiaran, Leyre, additional, Alonso-Gómez, Ángel M., additional, Contreras-Fernández, Eugenio, additional, Abete, Itziar, additional, Sánchez-Villegas, Almudena, additional, Casas, Rosa, additional, Muñoz-Garach, Araceli, additional, Santos-Lozano, José Manuel, additional, Gallardo-Alfaro, Laura, additional, Basora, Josep, additional, Portoles, Olga, additional, Muñoz, Miguel Ángel, additional, Moñino, Manuel, additional, Miralles Gisbert, Salvador Miralles, additional, Rodríguez, Anai Moreno, additional, Ruiz-Canela, Miguel, additional, Palau Galindo, Antoni Palau, additional, Pérez-Vega, Karla Alejandra, additional, and Bueno-Cavanillas, Aurora, additional
Published: 2019
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180. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Author: Papandreou, Christopher, primary, Babio, Nancy, additional, Díaz-López, Andrés, additional, Martínez-González, Miguel, additional, Becerra-Tomas, Nerea, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Muñoz-Garach, Araceli, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Bulló, Mónica, additional, Sorli, Jose, additional, Quifer, Mireia, additional, Colom, Antoni, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Barón-López, Javier, additional, Pérez-Farinós, Napoleón, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Fernández-Garcia, José, additional, Santos-Lozano, José, additional, Corbella, Emili, additional, del M. Bibiloni, Maria, additional, Diez-Espino, Javier, additional, Asensio, Eva, additional, Torras, Laura, additional, Morey, Marga, additional, Compañ-Gabucio, Laura, additional, Salaverria-Lete, Itziar, additional, Cenoz-Osinaga, Juan, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional
Published: 2019
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181. Nut Consumptions as a Marker of Higher Diet Quality in a Mediterranean Population at High Cardiovascular Risk

Author: Bibiloni, Maria, primary, Julibert, Alicia, additional, Bouzas, Cristina, additional, Martínez-González, Miguel, additional, Corella, Dolores, additional, Salas-Salvadó, Jordi, additional, Zomeño, M., additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Martínez, J., additional, Wärnberg, Julia, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Bueno-Cavanillas, Aurora, additional, Arós, Fernando, additional, Tinahones, Francisco, additional, Serra-Majem, Lluis, additional, Martín, Vicente, additional, Lapetra, José, additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Ros, Emilio, additional, Fernández-Carrión, Rebeca, additional, Garcia-Rios, Antonio, additional, Zulet, M., additional, Orozco-Beltrán, Domingo, additional, Schröder, Helmut, additional, Fitó, Montserrat, additional, Bulló, Mónica, additional, Basora, Josep, additional, Cenoz, Juan, additional, Diez-Espino, Javier, additional, Toledo, Estefanía, additional, and Tur, Josep, additional
Published: 2019
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182. Risk factors differentially associated with non-alcoholic fatty liver disease in males and females with metabolic syndrome

Author: Bullón Vela, María Vanessa, primary, Abete, Itziar, additional, Zulet, María de los Ángeles, additional, Tur, Josep A., additional, Pintó, Xavier, additional, Corbella, Emili, additional, Martínez González, Miguel Ángel, additional, Corella, Dolores, additional, Macías, Manuel, additional, Tinahones, Francisco, additional, Fitó, Montserrat, additional, Estruch, Ramón, additional, Ros, Emilio, additional, Salas Salvadó, Jordi, additional, Daimiel, Lidia, additional, and Martínez, J. Alfredo, additional
Published: 2019
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183. Dietary Intake in Population with Metabolic Syndrome: Is the Prevalence of Inadequate Intake Influenced by Geographical Area? Cross-Sectional Analysis from PREDIMED-Plus Study

Author: Medicina, Medikuntza, Cano Ibáñez, Naomi, Bueno Cavanillas, Aurora, Martínez González, Miguel Ángel, Corella, Dolores, Salas Salvadó, Jordi, Zomeño Blanquerna, María Dolores, García de la Hera, Manoli, Romaguera, Dora, Martínez, J. Alfredo, Barón López, F. Javier, García Ríos, Antonio, Estruch, Ramón, García Molina, Laura, Alonso Gómez, Ángel María, Tur, Josep A., Tinahones, Francisco J., Serra Majem, Lluís, Cubelos Fernández, Naiara, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía Martín, Pilar, Ros, Emilio, Díez Espino, Javier, Fernández Carrión, Rebeca, Basora, Josep, Fitó, Montserrat, Zazo, Juan Manuel, Colom, Antoni, Toledo, Estefanía, Díaz López, Andrés, Muñoz, Miguel Ángel, Ruiz Canela, Miguel, Gea, Alfredo, Medicina, Medikuntza, Cano Ibáñez, Naomi, Bueno Cavanillas, Aurora, Martínez González, Miguel Ángel, Corella, Dolores, Salas Salvadó, Jordi, Zomeño Blanquerna, María Dolores, García de la Hera, Manoli, Romaguera, Dora, Martínez, J. Alfredo, Barón López, F. Javier, García Ríos, Antonio, Estruch, Ramón, García Molina, Laura, Alonso Gómez, Ángel María, Tur, Josep A., Tinahones, Francisco J., Serra Majem, Lluís, Cubelos Fernández, Naiara, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía Martín, Pilar, Ros, Emilio, Díez Espino, Javier, Fernández Carrión, Rebeca, Basora, Josep, Fitó, Montserrat, Zazo, Juan Manuel, Colom, Antoni, Toledo, Estefanía, Díaz López, Andrés, Muñoz, Miguel Ángel, Ruiz Canela, Miguel, and Gea, Alfredo
Abstract: Inadequate diet influences chronic diseases such as cardiovascular disease (CVD), the leading cause of death in Spain. CVD figures vary from one geographical region to another; this could be associated with different food choices. Our aim was to analyse the influence of geographical area on nutrient intakes among the Spanish adult population with Metabolic Syndrome (MetS). We analysed cross-sectional baseline data from the PREDIMED-Plus study: 6646 Spanish adults, aged 55⁻75 years, with overweight/obesity and MetS in four geographical areas. A validated 143-item Food Frequency Questionnaire (FFQ) was used to assess energy and nutrient intakes. The prevalence of inadequate nutrient intake was estimated according to Dietary Reference Intakes (DRIs). Multivariable-adjusted logistic regression was used to assess the relationship between geographical area (North, Central, East and South areas) and inadequate nutrient intake. People in the North area consumed significantly lower amounts of vegetables and fish but more sugar and alcohol (p < 0.001) than other areas. Dietary fibre, vitamin A, E, calcium and magnesium intakes were all lower among men of North area than in the other areas (p < 0.001). Sex (women), non-smoker and physical activity were also associated to adequate nutrient intake. Geographical area influences nutrient intakes. Its effect on dietary quality should be taken into account when planning food policies.
Published: 2018

184. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Author: Medicina, Medikuntza, Sánchez Villegas, Almudena, Álvarez Pérez, Jacqueline, Toledo, Estefanía, Salas Salvadó, Jordi, Ortega Azorín, Carolina, Zomeño Blanquerna, María Dolores, Vioque, Jesús, Martínez, José Alfredo, Romaguera, Dora, Pérez López, Jessica, López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Tur, Josep A., Tinahones, Francisco J., Lecea, Oscar, Martín, Vicente, Ortega Calvo, M., Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Corella, Dolores, Díaz López, Andrés, Babio, Nancy, Muñoz, Miguel Ángel, Fitó, Montserrat, García de la Hera, Manoli, Abete, Itziar, García Ríos, Antonio, Ros, Emilio, Ruíz Canela, Miguel, Martínez González, Miguel Ángel, Izquierdo, Marisol, Serra Majem, Lluís, Medicina, Medikuntza, Sánchez Villegas, Almudena, Álvarez Pérez, Jacqueline, Toledo, Estefanía, Salas Salvadó, Jordi, Ortega Azorín, Carolina, Zomeño Blanquerna, María Dolores, Vioque, Jesús, Martínez, José Alfredo, Romaguera, Dora, Pérez López, Jessica, López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Tur, Josep A., Tinahones, Francisco J., Lecea, Oscar, Martín, Vicente, Ortega Calvo, M., Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Corella, Dolores, Díaz López, Andrés, Babio, Nancy, Muñoz, Miguel Ángel, Fitó, Montserrat, García de la Hera, Manoli, Abete, Itziar, García Ríos, Antonio, Ros, Emilio, Ruíz Canela, Miguel, Martínez González, Miguel Ángel, Izquierdo, Marisol, and Serra Majem, Lluís
Abstract: BACKGROUND: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (omega-3 PUFA) intake, and depression prevalence. METHODS: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and omega-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and omega-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) omega-3 PUFA intake and depressive symptoms. RESULTS: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC omega-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. CONCLUSION: In our study, moderate fish and LC omega-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
Published: 2018

185. Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

Author: Medicina, Medikuntza, Schröder, Helmut, Cárdenas Fuentes, Gabriela, Martínez González, Miguel Ángel, Corella, Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Tinahones, Francisco J., López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Marcos, Ascensión, Tur, Josep A., Warnberg, Julia, Serra Majem, Lluís, Martín, Vicente, Vázquez, Clotilde, Lapetra, José, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía Martín, Pilar, Ros, Emilio, Castañer, Olga, Lassale, Camille, Ruiz Canela, Miguel, Asensio, Eva M., Basora, Josep, Torres Collado, Laura, García Ríos, Antonio, Abete, Itziar, Toledo, Estefanía, Buil Cosiales, Pilar, Bullo, Mònica, Goday, Albert, Fitó, Montserrat, Salas Salvadó, Jordi, PREDIMED-Plus investigator, Medicina, Medikuntza, Schröder, Helmut, Cárdenas Fuentes, Gabriela, Martínez González, Miguel Ángel, Corella, Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Tinahones, Francisco J., López Miranda, José, Estruch, Ramón, Bueno Cavanillas, Aurora, Arós Borau, Luis Fernando, Marcos, Ascensión, Tur, Josep A., Warnberg, Julia, Serra Majem, Lluís, Martín, Vicente, Vázquez, Clotilde, Lapetra, José, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía Martín, Pilar, Ros, Emilio, Castañer, Olga, Lassale, Camille, Ruiz Canela, Miguel, Asensio, Eva M., Basora, Josep, Torres Collado, Laura, García Ríos, Antonio, Abete, Itziar, Toledo, Estefanía, Buil Cosiales, Pilar, Bullo, Mònica, Goday, Albert, Fitó, Montserrat, Salas Salvadó, Jordi, and PREDIMED-Plus investigator
Abstract: BackgroundThe development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvencion con DIeta MEDiterranea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component.MethodsPREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n=6059; mean age 654.9years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups.ResultsAfter 12months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109.7-136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p<0.01) in both groups. A significant (p<0.001) time*intervention group interaction was found for Total-PA and MVPA, meaning the PA trajectory over time differed between the intervention and control groups. Age, sex, education level, and BMI did not moderate the effectiveness of th
Published: 2018

186. The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress

Author: Instituto de Salud Carlos III, Fundación Ramón Areces, European Commission, Fundación Renal Íñigo Álvarez de Toledo, Ministerio de Economía, Industria y Competitividad (España), Miguela, Verónica, Cui, Julia Y., Daimiel, Lidia, Espinosa-Díez, Cristina, Fernández-Hernando, Carlos, Kavanagh, Terrance J., Lamas Peláez, Santiago, Instituto de Salud Carlos III, Fundación Ramón Areces, European Commission, Fundación Renal Íñigo Álvarez de Toledo, Ministerio de Economía, Industria y Competitividad (España), Miguela, Verónica, Cui, Julia Y., Daimiel, Lidia, Espinosa-Díez, Cristina, Fernández-Hernando, Carlos, Kavanagh, Terrance J., and Lamas Peláez, Santiago
Abstract: Significance: MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors. Critical Issues: The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed. Future Directions: We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles. Antioxid. Redox Signal. 28, 773-796.
Published: 2018

187. Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

Author: Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, European Commission, Schröder, Helmut, Cárdenas-Fuentes, Gabriela, Martínez-González, Miguel Ángel, Corella, Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Tinahones, Francisco J., Miranda, José L., Estruch, Ramón, Bueno-Cavanillas, Aurora, Arós, Fernando, Marcos, Ascensión, Tur, Josep A., Wärnberg, Julia, Serra-Majem, Lluis, Martín, Vicente, Vázquez, Clotilde, Lapetra, José, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía-Martín, Pilar, Ros, Emilio, Castañer, Olga, Lassale, Camille, Ruiz-Canela, Miguel, Asensio, Eva M., Basora, Josep, Torres-Collado, Laura, Garcia-Rios, Antonio, Abete, Itziar, Toledo, Estefania, Buil-Cosiales, Pilar, Bulló, Mònica, Goday, Albert, Fitó, Montserrat, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, European Commission, Schröder, Helmut, Cárdenas-Fuentes, Gabriela, Martínez-González, Miguel Ángel, Corella, Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Tinahones, Francisco J., Miranda, José L., Estruch, Ramón, Bueno-Cavanillas, Aurora, Arós, Fernando, Marcos, Ascensión, Tur, Josep A., Wärnberg, Julia, Serra-Majem, Lluis, Martín, Vicente, Vázquez, Clotilde, Lapetra, José, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía-Martín, Pilar, Ros, Emilio, Castañer, Olga, Lassale, Camille, Ruiz-Canela, Miguel, Asensio, Eva M., Basora, Josep, Torres-Collado, Laura, Garcia-Rios, Antonio, Abete, Itziar, Toledo, Estefania, Buil-Cosiales, Pilar, Bulló, Mònica, Goday, Albert, Fitó, Montserrat, and Salas-Salvadó, Jordi
Abstract: [Background] The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component., [Methods] PREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n = 6059; mean age 65 ± 4.9 years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups., [Results] After 12 months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109.7–136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p < 0.01) in both groups. A significant (p < 0.001) time*intervention group interaction was found for Total-PA and MVPA, meaning the PA trajectory over time differed between the intervention and control groups. Age, sex, education level, and BMI did not moderate the effectiveness of the PA intervention. BMI and WC decreased significantly with increasing MVPA, compared with participants who reported no changes in MVPA., [Conclusion] After one year of follow-up, the PREDIMED-Plus PA intervention has been effective in increasing daily PA in older adults., [Trial registration] Retrospectively registered at the International Standard Randomized Controlled Trial (http://www.isrctn.com/ISRCTN89898870), registration date: 24 July 2014.
Published: 2018

188. Asociación entre índice tobillo-brazo y rendimiento cognitivo en participantes del estudio PREDIMED-Plus: estudio transversal

Author: López, Meritxell, Ríos, Angel, Romaguera, Dora, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Vioque, Jesús, Alonso-Gómez, Ángel M., Crespo-Oliva, Edelys, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García-Ríos, Antonio, Bueno-Cavanillas, Aurora, Gaforio, José J., Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Sanz-Martínez, Enrique, Ros, Emilio, Toledo, Estefanía, Barrubés, Laura, Barragán, Rocío, de la Torre, Rafael, Fiol, Miquel, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Martín-Ruiz, María Victoria, Zulet, María Ángeles, Díaz-Collado, Fátima, Casas, Rosa, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Mallorqui-Bagué, Nuria, Argelich, Emma, Lecea, Óscar, Paz-Graniel, Indira, Sorlí, José V., Cuenca, Aida, Munuera, Susana, Hernándis-Marsán, María Vicenta, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Camacho-Barcia, Lucía, Jiménez-Murcia, Susana, Castañer, Olga, and Yáñez, Aina M.
Abstract: El índice tobillo-brazo (ITB) es un indicador de enfermedad arterial periférica (EAP). El objetivo de este estudio es evaluar la asociación entre la EAP medida con el ITB y el rendimiento cognitivo de individuos con sobrepeso u obesidad y síndrome metabólico.
Published: 2021
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189. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study.

Author: Paz-Graniel, Indira, Babio, Nancy, Serra-Majem, Luís, Vioque, Jesús, Zomeño, Maria Dolores, Corella, Dolores, Díaz-López, Andrés, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Daimiel, Lidia, Martínez, J. Alfredo, Becerra-Tomás, Nerea, Navarrete-Muñoz, Eva Mª, Schröder, Helmut, Fernández-Carrión, Rebeca, Ortiz-Andrellucchi, Adriana, Corbella, Emili, Riquelme-Gallego, Blanca, and Gallardo-Alfaro, Laura
Subjects: ALCOHOLIC beverages, BEVERAGES, CARDIOVASCULAR diseases risk factors, CONFIDENCE intervals, DRINKING (Physiology), MEDICAL protocols, MULTIVARIATE analysis, QUESTIONNAIRES, RISK assessment, SEX distribution, WATER, MULTIPLE regression analysis, SOCIOECONOMIC factors, LIFESTYLES, CROSS-sectional method, PHYSICAL activity, ODDS ratio
Abstract: Purpose: We aimed to evaluate associations between compliance with recommendations for total water intake (TWI) and total water intake from fluids (TWIF), and some socio-demographic and lifestyle factors of a senior Mediterranean population at high cardiovascular risk. Methods: Cross-sectional analysis with data of 1902 participants from the PREDIMED-Plus study. A validated 32-item Spanish fluid-intake questionnaire was used to assess beverage consumption and water intake. Multivariable logistic regression models were used to assess the odds ratio (OR) and the 95% confidence interval (CI) for complying with European Food Safety Agency recommendations for TWI and TWIF according to various socio-demographic and lifestyle factors, and for the joint associations of Mediterranean diet (MedDiet) adherence and moderate–vigorous physical activity (MVPA). Results: The mean total volume of fluid intake in the population studied was 1934 ± 617 mL/day. Water was the most frequently consumed beverage. Significant differences between sex were only observed in alcoholic and hot beverage consumption. Compliance with TWIF was associated with being women (OR 3.02; 2.40, 3.80), high adherence to MedDiet (OR 1.07; 1.02, 1.12), and participants who were more engaged in physical activity (PA) (OR 1.07; 1.02, 1.13). Age was inversely associated (OR 0.96; 0.94, 0.98). Similar results for TWI recommendations compliance were observed in relation to being women (OR 5.34; 3.85, 7.42), adherence to MedDiet (OR 1.16; 1.02, 1.31) and PA (OR 1.07; 1.00, 1.15). The joint association of PA and MedDiet, showed that participants with higher adherence to MedDiet and meeting WHO recommendations for MVPA complied better with the TWI recommendations (OR 1.66; 1.19, 2.32). Conclusions: High compliance with recommendations for TWI was associated with being a woman, and a healthy lifestyle characterized by high adherence to the MedDiet and PA. [ABSTRACT FROM AUTHOR]
Published: 2020
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190. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Author: Sánchez-Villegas, Almudena, primary, Álvarez-Pérez, Jacqueline, additional, Toledo, Estefanía, additional, Salas-Salvadó, Jordi, additional, Ortega-Azorín, Carolina, additional, Zomeño, Maria, additional, Vioque, Jesús, additional, Martínez, Jose, additional, Romaguera, Dora, additional, Pérez-López, Jessica, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Bueno-Cavanillas, Aurora, additional, Arós, Fernando, additional, Tur, Josep, additional, Tinahones, Francisco, additional, Lecea, Oscar, additional, Martín, Vicente, additional, Ortega-Calvo, M., additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Corella, Dolores, additional, Díaz-López, Andrés, additional, Babio, Nancy, additional, Muñoz, Miguel, additional, Fitó, Montserrat, additional, García de la Hera, Manoli, additional, Abete, Itziar, additional, García-Rios, Antonio, additional, Ros, Emilio, additional, Ruíz-Canela, Miguel, additional, Martínez-González, Miguel, additional, Izquierdo, Marisol, additional, and Serra-Majem, Lluis, additional
Published: 2018
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191. Dietary Intake in Population with Metabolic Syndrome: Is the Prevalence of Inadequate Intake Influenced by Geographical Area? Cross-Sectional Analysis from PREDIMED-Plus Study

Author: Cano-Ibáñez, Naomi, primary, Bueno-Cavanillas, Aurora, additional, Martínez-González, Miguel, additional, Corella, Dolores, additional, Salas-Salvadó, Jordi, additional, Zomeño, M., additional, García-de-la-Hera, Manoli, additional, Romaguera, Dora, additional, Martínez, J., additional, Barón-López, F., additional, García-Ríos, Antonio, additional, Estruch, Ramón, additional, García-Molina, Laura, additional, Alonso Gómez, Ángel, additional, Tur, Josep, additional, Tinahones, Francisco, additional, Serra-Majem, Lluis, additional, Cubelos-Fernández, Naiara, additional, Lapetra, José, additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Gaforio, José, additional, Matía, Pilar, additional, Ros, Emilio, additional, Diez-Espino, Javier, additional, Fernández-Carrión, Rebeca, additional, Basora, Josep, additional, Fitó, Montse, additional, Zazo, Juan, additional, Colom, Antoni, additional, Toledo, Estefanía, additional, Díaz-López, Andrés, additional, Muñoz, Miguel, additional, Ruiz-Canela, Miguel, additional, and Gea, Alfredo, additional
Published: 2018
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192. Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study

Author: Mallorquí-Bagué, Núria, primary, Lozano-Madrid, María, additional, Toledo, Estefanía, additional, Corella, Dolores, additional, Salas-Salvadó, Jordi, additional, Cuenca-Royo, Aida, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Martínez, J. Alfredo, additional, Wärnberg, Julia, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Bueno-Cavanillas, Aurora, additional, Alonso-Gómez, Ángel, additional, Tur, Josep A., additional, Tinahones, Francisco J., additional, Serra-Majem, Lluís, additional, Martín, Vicente, additional, Lapetra, José, additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Gaforio, José J., additional, Matía, Pilar, additional, Ros, Emilio, additional, Granero, Roser, additional, Buil-Cosiales, Pilar, additional, Barragán, Rocío, additional, Bulló, Mònica, additional, Castañer, Olga, additional, García-de-la-Hera, Manoli, additional, Yáñez, Aina M., additional, Abete, Itziar, additional, García-Ríos, Antonio, additional, Ruiz-Canela, Miguel, additional, Díaz-López, Andrés, additional, Jiménez-Murcia, Susana, additional, Martínez-González, Miguel A., additional, De la Torre, Rafael, additional, and Fernández-Aranda, Fernando, additional
Published: 2018
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193. The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress

Author: Miguel, Verónica, primary, Cui, Julia Yue, additional, Daimiel, Lidia, additional, Espinosa-Díez, Cristina, additional, Fernández-Hernando, Carlos, additional, Kavanagh, Terrance J., additional, and Lamas, Santiago, additional
Published: 2018
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194. Leisure-time physical activity, sedentary behaviors, sleep, and cardiometabolic risk factors at baseline in the PREDIMED-PLUS intervention trial: A cross-sectional analysis

Author: Universitat Rovira i Virgili, Rosique-Esteban, Nuria; Diaz-Lopez, Andres; Martinez-Gonzalez, Miguel A.; Corella, Dolores; Goday, Albert; Alfredo Martinez, J.; Romaguera, Dora; Vioque, Jesus; Aros, Fernando; Garcia-Rios, Antonio; Tinahones, Francisco; Estruch, Ramon; Carlos Fernandez-Garcia, Jose; Lapetra, Jose; Serra-Majem, Luis; Pinto, Xavier; Tur, Josep A.; Bueno-Cavanillas, Aurora; Vidal, Josep; Delgado-Rodriguez, Miguel; Daimiel, Lidia; Vazquez, Clotilde; Angel Rubio, Miguel; Ros, Emilio; Salas-Salvado, Jordi;PREDIMED-PLUS Investigators, Universitat Rovira i Virgili, and Rosique-Esteban, Nuria; Diaz-Lopez, Andres; Martinez-Gonzalez, Miguel A.; Corella, Dolores; Goday, Albert; Alfredo Martinez, J.; Romaguera, Dora; Vioque, Jesus; Aros, Fernando; Garcia-Rios, Antonio; Tinahones, Francisco; Estruch, Ramon; Carlos Fernandez-Garcia, Jose; Lapetra, Jose; Serra-Majem, Luis; Pinto, Xavier; Tur, Josep A.; Bueno-Cavanillas, Aurora; Vidal, Josep; Delgado-Rodriguez, Miguel; Daimiel, Lidia; Vazquez, Clotilde; Angel Rubio, Miguel; Ros, Emilio; Salas-Salvado, Jordi;PREDIMED-PLUS Investigators
Abstract: Limited data exists on the interrelationships between physical activity (PA), sedentary behaviors and sleep concerning cardiometabolic risk factors in aged adults at high cardiovascular disease risk. Our aim was to examine independent and joint associations between time spent in leisure-time PA, sedentary behaviors and sleep on the prevalence of obesity, type 2 diabetes (T2D) and components of the metabolic syndrome (MetS) in Mediterranean individuals at high cardiovascular risk. Cross-sectional analyses were performed on baseline data from 5776 Spanish adults (aged 55-75y in men; 60-75y in women) with overweight/obesity and MetS, from October 2013 to October 2016, in the PREDIMED-PLUS trial. Employing multivariable-adjusted Cox regression with robust variance and constant time (given the cross-sectional design), higher prevalence of obesity, T2D and abdominal obesity as component of the MetS were associated with greater time in TV-viewing (Relative Risk, RR: 1.02, 95%CI: 1.01, 1.03; RR:1.04, 95%CI: 1.02, 1.06 and RR: 1.01 95%CI: 1.00, 1.02; respectively, all P < .01). Conversely, greater time in moderate-vigorous PA (MVPA) was associated with lower prevalence of obesity, T2D, abdominal obesity and low HDL-cholesterol (RR: 0.95, 95%CI: 0.93, 0.97; RR: 0.94, 95%CI: 0.89, 0.99; RR: 0.97, 95%CI: 0.96, 0.98; and RR: 0.95, 95%CI: 0.91, 0.99, respectively, all P < .05). For these outcomes, theoretically substituting 1-h/day of MVPA for 1-h/day TV-viewing was also significantly associated with lower prevalence (RR 0.91 to 0.97, all P < .05). Similar lower RR in these outcomes was observed when substituting 1-h/day of MVPA for 1-h/day of sleeping. Longer time watching TV and not meeting MVPA recommendations were jointly associated with higher RR of the prevalence of obesity and
Published: 2017

195. Epigenetic Biomarkers of Biological Age

Author: Daimiel, Lidia and Micó, Victor
Published: 2015
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196. Macrophage deficiency of miR‐21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis

Author: Canfrán‐Duque, Alberto, primary, Rotllan, Noemi, additional, Zhang, Xinbo, additional, Fernández‐Fuertes, Marta, additional, Ramírez‐Hidalgo, Cristina, additional, Araldi, Elisa, additional, Daimiel, Lidia, additional, Busto, Rebeca, additional, Fernández‐Hernando, Carlos, additional, and Suárez, Yajaira, additional
Published: 2017
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197. NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging

Author: Micó, Víctor, primary, Berninches, Laura, additional, Tapia, Javier, additional, and Daimiel, Lidia, additional
Published: 2017
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198. Nutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health

Author: Micó, Víctor, primary, Díez-Ricote, Laura, additional, and Daimiel, Lidia, additional
Published: 2016
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199. Unsuccessful Detection of Plant MicroRNAs in Beer, Extra Virgin Olive Oil and Human Plasma After an Acute Ingestion of Extra Virgin Olive Oil

Author: Micó, Victor, primary, Martín, Roberto, additional, Lasunción, Miguel A., additional, Ordovás, Jose M., additional, and Daimiel, Lidia, additional
Published: 2016
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200. Dieta mediterránea hipocalórica y factores de riesgo cardiovascular: análisis transversal de PREDIMED-Plus

Author: Álvarez-Álvarez, Ismael, Martínez-González, Miguel Á., Sánchez-Tainta, Ana, Corella, Dolores, Díaz-López, Andrés, Fitó, Montserrat, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, López-Miranda, José, Estruch, Ramón, Bueno-Cavanillas, Aurora, Arós, Fernando, Tur, Josep A., Tinahones, Francisco J., Serra-Majem, Lluís, Martín, Vicente, Lapetra, José, Más Fontao, Sebastián, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía, Pilar, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Becerra-Tomás, Nerea, Castañer, Olga, Schröder, Helmut, Navarrete-Muñoz, Eva M., Zulet, M. Ángeles, García-Ríos, Antonio, Salas-Salvadó, Jordi, Díez-Espino, Javier, and Toledo, Estefanía
Abstract: Los beneficios cardiovasculares de la dieta mediterránea se han evaluado bajo supuestos de ingesta total de energía ad libitum(sin restricción de energía). En el presente trabajo se estudia basalmente la cohorte de un gran ensayo en marcha denominado PREDIMED-Plus y la asociación entre la adherencia a la dieta mediterránea hipocalórica según la escala de 17 puntos (MedDiet) de este ensayo con la prevalencia inicial de factores de riesgo cardiovascular (FRCV).
Published: 2019
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