779 results on '"Da, Zhu"'
Search Results
152. Pure Windfall Gain and Stock Market Participation: Evidence from Administrative Data
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Tzu-Chang Forrest Cheng, Hsuan-Hua Huang, Tse-Chun Lin, Tzu‐Ting Yang, and Jian-Da Zhu
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2021
- Full Text
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153. High energy density supercapacitor electrode materials based on mixed metal MOF and its derived C@bimetal hydroxide embedded onto porous support
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Jin-Da, Zhu, primary, Li-Bing, Liu, additional, and Ze-Qing, Yang, additional
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- 2021
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154. Global dynamical analysis of an electronic spinâ€"orbit coupling system.
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Zou, Ming and Ma, Da-Zhu
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- 2022
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155. Fabrication and characterization of needle-like nano-HA and HA/MWNT composites
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Meng, Y. H., Tang, Chak Yin, Tsui, Chi Pong, and Chen, Da Zhu
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- 2008
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156. Integral Equation Domain Decomposition Method Based on the Out-of-Core Solver
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Xunwang Zhao, Yingyu Liu, Zhongchao Lin, Ming-Da Zhu, Peng Hou, and Chang Zhai
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Robustness (computer science) ,Computer science ,0202 electrical engineering, electronic engineering, information engineering ,Boundary (topology) ,Applied mathematics ,020206 networking & telecommunications ,Domain decomposition methods ,02 engineering and technology ,Krylov subspace ,Solver ,Integral equation ,Matrix decomposition ,Block (data storage) - Abstract
A integral-equation domain decomposition method based on the blocked out-of-core iterative solver is presented for accurately analyzing large-scale electromagnetic scattering objects. The proposed method is based on the matrix partitioning, which decomposes the original large complex matrix into several small sub-matrices constructed from sub-problems. Then, the Krylov subspace method based on the out-of-core strategy is used to solve the matrix equation block by block. The continuity of the electric surface current across the boundary between adjacent sub-domains is enforced by the proposed scheme. Numerical examples demonstrate the accuracy, effectiveness and robustness of the proposed approach.
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- 2020
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157. An Oscillatory Quadrature Method for the Time-Domain Integral Equation using Laguerre Functions
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Zhongchao Lin, Ming-Da Zhu, Yu Zhang, and Xunwang Zhao
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Physics ,Degree (graph theory) ,Scattering ,Mathematical analysis ,0202 electrical engineering, electronic engineering, information engineering ,Laguerre polynomials ,Nyström method ,020206 networking & telecommunications ,Basis function ,02 engineering and technology ,Integral equation ,Instability ,Quadrature (mathematics) - Abstract
The marching-on-in-degree (MOD) scheme which adopts the Laguerre functions as temporal basis functions, is one of the solutions of the time-domain integral equations (TDIE). It has been proved that the oscillatory integrals involving Laguerre functions may cause instability in the MOD method when marching on to a high degree. Therefore, a novel oscillatory quadrature method for Laguerre functions is proposed for stabilizing TDIE-MOD in this paper. The proposed oscillatory quadrature is applicable to the solution of time-domain magnetic field integral equations. Some numerical results of the transient scattering problem are given to show the effectiveness of the proposed oscillatory quadrature for the Laguerre functions in stable solution of TDIE.
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- 2020
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158. Numerical Evaluation of Weakly Near-Singular Integrals in Time-Domain Integral Equations
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Yu Zhang, Ming-Da Zhu, Xunwang Zhao, and Zhongchao Lin
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Electromagnetics ,Mathematical analysis ,MathematicsofComputing_NUMERICALANALYSIS ,020206 networking & telecommunications ,Basis function ,02 engineering and technology ,Singular integral ,Integral equation ,Domain (mathematical analysis) ,Singularity ,Transformation (function) ,Rate of convergence ,ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION ,0202 electrical engineering, electronic engineering, information engineering ,Mathematics - Abstract
A new singularity cancellation transformation is presented for calculating weakly near-singular integrals in time-domain integral equations. On one hand, the singularity cancellation method is a numerical technique for singularity treatments, which is relatively simple and kernel-independent. The integral kernels of time-domain integral equations depend on the temporal basis functions and solution methodologies, which benefit from the generality of cancellation transformations. On the other hand, the singularity cancellation transformations for weakly near-singular integrals are inefficient on the deformed triangular domain, which is referred to as shape-dependence in this paper. The shape-dependence issue is a main problem of singularity cancellation methods. Therefore, the reason of shape-dependence is investigated via the theoretical analysis in this work. Second, a new singularity cancellation transformation is proposed for calculating weakly near-singular integrals in time-domain integral equations, which have fast and consistent convergence rate for both regular and irregular triangles. Some numerical results are given to show the effectiveness of the proposed variable transformation.
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- 2020
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159. The Effect of Neoadjuvant Chemotherapy on Lymph Node Metastasis of FIGO Stage IB1-IIB Cervical Cancer: A Systematic Review and Meta-Analysis
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Da Zhu, Lu Mao, Hui Shen, Liming Wang, Ci Ren, Bingxin Chen, Hui Wang, and Wencheng Ding
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0301 basic medicine ,medicine.medical_specialty ,Cancer Research ,medicine.medical_treatment ,Subgroup analysis ,Gastroenterology ,lcsh:RC254-282 ,law.invention ,surgery ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,uterine cervical neoplasms ,medicine ,lymphatic metastasis ,Stage (cooking) ,Radical surgery ,Cervical cancer ,Chemotherapy ,lymph node metastasis ,business.industry ,Incidence (epidemiology) ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Meta-analysis ,Systematic Review ,business ,neoadjuvant chemotherapy - Abstract
Objectives This study aimed to assess the effect of neoadjuvant chemotherapy (NACT) on the rate of lymph node metastasis (LNM) in FIGO stage IB1-IIB cervical cancer patients and compare the LNM between NACT plus surgery and surgery only. Methods We identified 34 eligible studies in PubMed, Web of Science, Cochrane Library, and EMBASE from inception to July 27, 2019. Data analyses were performed by Stata (version 13) and Revman (version 5.3). Results In these 34 included studies, the pooled incidence of LNM was estimated as 23% (95% CI, 0.20-0.26; I2 = 79.6%, P
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- 2020
160. Valvular Disease and Three-Dimensional Printing
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Yongjian Wu, Fanglin Lu, Xin Pan, Fang Fang, Yang Liu, Xiaoke Shang, Da Zhu, Jian Yang, Yanyan Ma, Haibo Zhang, and Jiayou Tang
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medicine.medical_specialty ,Valvular disease ,business.industry ,Three dimensional printing ,medicine ,Radiology ,business - Published
- 2020
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161. Comparison of the Analytical Formulations and Variable Transformations for Near-Singularity Quadrature Involving the Static Potentials
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Yu Zhang, Tapan K. Sarkar, Xunwang Zhao, Zhongchao Lin, and Ming-Da Zhu
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Singularity ,Subtractive color ,Rate of convergence ,Convergence (routing) ,Applied mathematics ,Stability (probability) ,Variable (mathematics) ,Mathematics ,Numerical stability ,Quadrature (mathematics) - Abstract
In this work, we first investigate the problem of the near-singularity and shape-dependence in the analytical methods. It is found that the analytical methods are not immune to the two problems, due to the subtractive cancellation and round-off error. In order to increase the stability of the analytical formulations, an investigation is performed to find alternative formulations for the extreme cases. On the other hand, we propose a new variable transformation which can achieve machine-precision accuracy for the extreme case with a fast convergence rate. Some numerical results are presented to compare the modified analytical formulations and the singularity cancellation methods.
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- 2020
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162. The Shape-Dependence and Near-Singularity of Singularity Cancellation Transformations for the Integral Equation Methods
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Xunwang Zhao, Zhongchao Lin, Ming-Da Zhu, Yu Zhang, and Tapan K. Sarkar
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Singularity ,Transformation (function) ,Rate of convergence ,Convergence (routing) ,0202 electrical engineering, electronic engineering, information engineering ,Applied mathematics ,020206 networking & telecommunications ,02 engineering and technology ,Numerical verification ,Integral equation ,Mathematics - Abstract
The near-singularity and shape-dependence are two main topics in the singularity cancellation methods which are well-known for the treatments of weakly singular and near-singular integrals. The cancellation transformations for near-singular integrals are inefficient for the deformed triangles, and this phenomenon is referred to as shape-dependence in this paper. We first investigate the reason of these problems via the theoretical analysis with the numerical verification. Second, a new singularity cancellation method for weakly near-singular integral is proposed, which have fast and consistent convergence rate for both regular and irregular triangles. Some numerical results are presented to show the effectiveness of the theoretical framework and the proposed transformation.
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- 2020
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163. [Study on quality standard of Bufonis Venenum and its processed slice, toad venom powder]
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Yun-Ge, Fang, Peng-Fei, Wang, Hou-da, Zhu, Liang-Mian, Chen, Zhi-Min, Wang, Hui-Min, Gao, Xin-Tong, Fu, and Jing, Nie
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Bufanolides ,Quality Control ,Amphibian Venoms ,Animals ,Powders ,Bufonidae ,Chromatography, High Pressure Liquid - Abstract
Bufonis Venenum(toad venom) is prepared from the dried secretion of Bufo bufo gargarizans or B. melanostictus. Toad venom powder is one of the processed slices of crude material toad venom. In the present study, the global quality control method and standard of toad venom and its processed slice, toad venom powder were established, including TLC identification, characteristic chromatogram and QAMS by HPLC. The relative correction factor(RCF) was re-calculated and validated. The average RCFs of cinobufagin to gamabufotalin, bufotalin, bufalin and resibufogenin were considered for the determination of five bufadienolides in the samples. The total amount in the different batches of the dried samples varied from 4.06% to 17.0%. Referring to the revised methods for crude materials, the quality standard of toad venom powder was drafted including appearance description, TLC examination, characteristic chromatogram, water content and the total amount of five bufadienolides. The present investigation provided scientific evidences for the quality standard improvement of toad venom to be described in the next edition of Chinese pharmacopoeia(2020 edition).
- Published
- 2020
164. [Study on revision of quality standard of Sophorae Flavescentis Radix and its processed slices]
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Yun-Ge, Fang, Hou-da, Zhu, Xiao-Qian, Liu, Liang-Mian, Chen, Chen-Xiao-Ning, Meng, Dong, Zhang, Hui-Min, Gao, and Zhi-Min, Wang
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Flavonoids ,Sophora ,Quinolizines ,Drugs, Chinese Herbal - Abstract
Sophorae Flavescentis Radix is prepared from the root of Sophora flavescens. The comprehensive knowledge of the effective components in S. flavescens makes its quality standard improvement more possible. TLC identification method for main flavonoids and alkaloids in one test was established using GF_(254) thin layer plate and the lower solution of chloroform-methanol-water-formic acid(4∶2∶1∶0.6) as developing solvent. The quantitative method of marker alkaloids was revised including the simplified sample preparation procedure and the chromatographic conditions. The determination of four alkaloids in the samples indicated that 32 batches of tested samples were qualified ones. The total oxymatrine and matrine, total oxysophocarpine and sophocarpine, as well as total amount of four tested components in the different samples were 1.08%-2.55%, 0.369%-0.860%, 1.67%-3.40%, respectively. There was a significantly positive correlation between oxymatrine and oxysophocarpine. Total oxymatrine and matrine had same correlation with total oxysophocarpine and sophocarpine. The moisture content and extractive in 32 batches of samples fulfilled the require of not more than 11.0% and not less than 20.0%, respectively. Thirteen tested pesticides were not detected in 12 batches of samples. The present study provided the evidence for the revision of quality standard of Sophora Flavescentis Radix.
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- 2020
165. [Determination of five steroidal saponins in Paridis Rhizoma and its adulterants as well as consideration on its quantitative method described in Chinese Pharmacopoeia (2015 edition)]
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Bo-Ya, Ju, Hou-da, Zhu, Yan-Min, Li, Rui, Wang, Liang-Mian, Chen, Hui-Min, Gao, and Zhi-Min, Wang
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China ,Liliaceae ,Saponins ,Melanthiaceae ,Rhizome - Abstract
Paridis Rhizoma is prepared from the dried rhizoma of Paris polyphylla var. yunnanensis or P. polyphylla var. chinensis. For the improvement of the quality standard of Paridis Rhizoma described in Chinese Pharmacopoeia(2015 edition), it is proposed that the quality marker no longer contains polyphyllin Ⅵ, and instead, polyphyllin H is an alternative for the quantitative analysis. To determine polyphyllin Ⅰ, Ⅱ, H and Ⅶ in the Paridis Rhizoma samples collected from the different growing area in China, HPLC method was established using the same chromatographic conditions as those for simultaneous determination of polyphyllin Ⅰ, Ⅱ, Ⅵ and Ⅶ described in Chinese Pharmacopoeia(2015 edition). The methodology validation indicated that there was a good linearity among the ranges of 0.006 48-0.828, 0.006 52-0.834, 0.006 17-0.790, 0.006 31-0.808 g·L~(-1) for polyphyllin Ⅰ, Ⅱ, H and Ⅶ, respectively. The average recoveries of four components were 100.2%-101.4%, with RSD less than 3.5%. The total amount of polyphyllin Ⅰ, Ⅱ, H and Ⅶ in the analyzed samples of P. polyphylla var. chinensis and P. polyphylla var. yunnanensis ranged from 0.050 9% to 3.99% and from 0.115% to 3.23%, respectively. In the tested samples collected from other Paris plants, there are high content of steroidal saponins in the samples of P. fargesii and P. forrestii, low content in the samples of P. polyphylla var. stenophylla, P. delavayi and P. thibetica, and almost not occurrence in the sample of P. mairei. As a representative adulterant of Paridis Rhizoma processed slices, 7 batches of Trillium samples contained high amount of polyphyllin Ⅵ and did not have polyphyllin H. Based on the present investigation, it is recommended that polyphyllin H together with polyphyllin Ⅰ, Ⅱ and Ⅶ are suitable for the improvement of quality standard of Paridis Rhizoma and the total amount of four components are not less than 0.80%.
- Published
- 2020
166. [Analysis and structural identification of relevant substances in Breviscapine for Injection]
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Hou-da, Zhu, Pan, Tian, Liang-Jun, Guan, Liang-Mian, Chen, Xiao-Qian, Liu, Hui-Min, Gao, and Zhi-Min, Wang
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Flavonoids ,Quality Control ,Glucuronides ,Magnetic Resonance Spectroscopy ,Apigenin ,Chromatography, High Pressure Liquid ,Mass Spectrometry ,Drugs, Chinese Herbal ,Injections - Abstract
To define the composition of relevant substances in Breviscapine for Injection, in order to improve the quality control of impurity, and ensure the clinical safety. The analysis and structural identification of relevant substances in different specifications and batches of Breviscapine for Injection powders were carried out by HPLC and UPLC-QTOF-MS. Three primary relevant substances, namely 5,6,7,3',4'-pentahydroxyflavone-7-O-glucuronide(3), 3,5,6,7,4'-pentahydroxyflavone-3-O-glucuronide(4) and scutellarein(10), as well as three minor impurities, namely 6-hydroxyapigenin-6-O-glucosyl-7-O-glucuronide(1), methoxylscutellarin(6) and apigenin-7-O-glucuronide(7) were structurally identified by matching retention time, UV spectra, and mass spectra with authentic compounds and MS fragmentation rules. The main relevant substances(3) and(4) were separated and purified by semi-preparative HPLC, and their structures were further confirmed by NMR data. The study defined relevant substances of Breviscapine for Injection, and provided reference for improving the quality control level of single impurity in breviscapine preparation.
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- 2020
167. Quasi-solid synthesis of nano-Pb/C composites for enhanced performance of lead-acid battery
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Kai-da Zhu, Xin-ru Wang, Jing Zhong, Jian Gu, and Sen-lin Wang
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Battery (electricity) ,Materials science ,Renewable Energy, Sustainability and the Environment ,Composite number ,Nano ,Energy Engineering and Power Technology ,Electrolyte ,Electrical and Electronic Engineering ,Composite material ,Lead–acid battery ,Electrochemistry ,Quasi-solid ,Dissolution - Abstract
Adding lead-carbon composite materials to the negative plate of lead-acid batteries can effectively improve the electrochemical performance of the battery. In this paper, a novel quasi-solid method is used to in-situ synthesize the nano-Pb/C composite as additives in the negative active material of lead-acid cells, which can greatly increase the utilization rate of negative active material and the initial discharge capacity of the lead-acid cell. Compared with the N C material, the nano-Pb/C composite effectively inhibits the hydrogen evolution reaction. In addition, since the nano-Pb/C composite and the negative active material in the negative plate form a porous framework, the diffusion of the electrolyte and the dissolution of PbSO4 are accelerated. The cell containing 1 wt.% nano-Pb/C composite has the best cycle performance (18,154 cycles) under high-rate partial-state-of-charge condition. All in all, the nano-Pb/C composite prepared via a new quasi-solid method has the advantages of improving the initial capacity and lifespan of lead-acid batteries, and it is a promising candidate material for lead-acid battery additives.
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- 2022
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168. Exome sequencing identifies somatic point mutations associated with acquired endocrine resistance in breast cancer cell lines
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Ehlers Natasja S, Da Zhu, Elias Daniel, Lin Xue, Li Jian, Bjerre Christina, Brunner Nils, Bolund Lars, Jun Wang, Gupta Ramneek, and Ditzel Henrik J
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Medicine ,Science - Published
- 2012
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169. A Typical Bilateral Atrial Myxoma: A Case Report
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Zhenghua Xiao, Wei Meng, Da Zhu, and Eryong Zhang
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Myxoma is a rare type of tumor which have an incidence of 0.0017% among the general population. Cardiac myxomas which arise from two different heart chambers is even extremely rare; we herein report a unique case of male patient with bilateral myxoma.
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- 2012
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170. Subnetwork identification and chemical modulation for neural regeneration: A study combining network guided forest and heat diffusion model
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Li-Da Zhu, Hui Wang, Hong-Yu Zhang, Bo Diao, Gang Wang, and Xuan Xu
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Neurite ,medicine.drug_class ,Applied Mathematics ,Histone deacetylase inhibitor ,Central nervous system ,Biology ,Sciatic nerve injury ,medicine.disease ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Computer Science Applications ,Trichostatin A ,medicine.anatomical_structure ,Dorsal root ganglion ,Ubiquinone biosynthetic process ,Modeling and Simulation ,Peripheral nervous system ,medicine ,Neuroscience ,medicine.drug - Abstract
The induction of neural regeneration is vital to the repair of spinal cord injury (SCI). While compared with peripheral nervous system (PNS), the regenerative capacity of the central nervous system (CNS) is extremely limited. This indicates that modulating the molecular pathways underlying PNS repair may lead to the discovery of potential treatment for CNS injury. Based on the gene expression profiles of dorsal root ganglion (DRG) after a sciatic nerve injury, we utilized network guided forest (NGF) to rank genes in terms of their capacity of distinguishing injured DRG from sham-operated controls. Gene importance scores deriving from NGF were used as initial heat in a heat diffusion model (HotNet2) to infer the subnetworks underlying neural regeneration in the DRG. After potential regulators of the subnetworks were found through Connectivity Map (cMap), candidate compounds were experimentally evaluated for their capacity to regenerate the damaged neurons. Gene ontology analysis of the subnetworks revealed ubiquinone biosynthetic process is crucial for neural regeneration. Moreover, almost half of the genes in these subnetworks are found to be related to neural regeneration via text mining. After screening compounds that are likely to modulate gene expressions of the subnetworks, three compounds were selected for the experiment. Of them, trichostatin A, a histone deacetylase inhibitor, was validated to enhance neurite outgrowth in vivo via an optic nerve crush mouse model. Our study identified subnetworks underlying neural regeneration, and validated a compound can promote neurite outgrowth by modulating these subnetworks. This work also suggests an alternative approach for drug repositioning that can be easily extended to other disease phenotypes.
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- 2018
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171. Physics-Based Modeling of Experimental Data Encountered in Cellular Wireless Communication
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Tapan K. Sarkar, Magdalena Salazar-Palma, Heng Chen, and Ming-Da Zhu
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0301 basic medicine ,business.industry ,Computer science ,Acoustics ,020206 networking & telecommunications ,Field strength ,Near and far field ,02 engineering and technology ,Interference (wave propagation) ,03 medical and health sciences ,030104 developmental biology ,Surface wave ,0202 electrical engineering, electronic engineering, information engineering ,Wireless ,Path loss ,Fading ,Electrical and Electronic Engineering ,Reflection coefficient ,Antenna (radio) ,business ,Radio wave - Abstract
This paper presents a physics-based macro model that can predict with a high degree of accuracy various experimental data available for the propagation path loss of radio waves in a cellular wireless environment. A theoretical macro model based on the classical Sommerfeld formulation can duplicate various experimental data including that of Okumura et al. carried out in 1968. It is important to point out that there are also many statistical models but they do not conform to the results of the available experimental data. Specifically, there are separate path loss propagation models available in the literature for waves traveling in urban, suburban, rural environments, and the like. However, no such distinction is made in the results obtained from the theoretical analysis and measured experimental data. Based on the analysis using the macro model developed after Sommerfeld’s classic century-old analytical formulation, one can also explain the origin of slow fading which is due to the interference between the direct wave from the base station antenna and the ground wave emanating from the reflections of the direct wave and occurs only in the near field of the transmitting antenna. The so-called height gain occurs in the far field of a base station antenna deployment which falls generally outside the cell of interest, while in the near field, within the cell, there is a height loss of the field strength for observation points near the ground. A physical realization of the propagation mechanism is illustrated through Vander Pol’s exact transformation of the Sommerfeld integrals for the potential to a spatial semiinfinite volume integral and thus illustrates why buildings, trees, and the like have little effects on the propagation mechanism.
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- 2018
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172. Probing the Interaction Mechanism between Oil-in-Water Emulsions and Electroless Nickel–Phosphorus Coating with Implications for Antifouling in Oil Production
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Jun Huang, Xiaoyong Qiu, Reza Sabbagh, Vahidoddin Fattahpour, Li Xiang, Wenjihao Hu, Mahdi Mahmoudi, Hongbo Zeng, Da Zhu, Lu Gong, Jing-Li Luo, and Ling Zhang
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Materials science ,Fouling ,General Chemical Engineering ,Surface force ,Energy Engineering and Power Technology ,02 engineering and technology ,engineering.material ,021001 nanoscience & nanotechnology ,Biofouling ,Electroless nickel ,Fuel Technology ,020401 chemical engineering ,Chemical engineering ,Coating ,13. Climate action ,Emulsion ,Lubrication ,engineering ,0204 chemical engineering ,0210 nano-technology ,Asphaltene - Abstract
Fouling issues are highly undesirable in oil industries, and stable water–oil emulsion is one of the major causes of fouling on pipelines, upgrading equipment, and other surfaces in oil production. Studying the interfacial interactions between emulsion drops and various metal substrates is of significant importance in the fundamental understanding of fouling mechanisms. In this work, surface force measurements using a drop probe atomic force microscope technique and fouling tests were applied to investigate the fouling and antifouling mechanisms of electron-beam-deposited iron substrates with and without electroless nickel–phosphorus (EN) coatings. The effects of oil or aqueous solution conditions have been systematically investigated, including the asphaltene concentration, salinity, pH, and presence of divalent ions. A theoretical model based on the Reynolds lubrication equation and augmented Young–Laplace equation has been applied to analyze the measured force profiles. Our results indicate that the at...
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- 2018
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173. Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy
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Ci Ren, Peng Wu, Chun Gao, Liming Wang, Xun Tian, Junbo Hu, Wencheng Ding, Jing Cheng, Rong Liu, Zhiping Zhang, Hui Wang, Hui Shen, Lan Yu, Zheng Hu, Ding Ma, Da Zhu, Ming Deng, Ling Xi, and Songwei Tan
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0301 basic medicine ,Polymers ,Papillomavirus E7 Proteins ,Mice, Nude ,Uterine Cervical Neoplasms ,Apoptosis ,HPV vaccines ,medicine.disease_cause ,Malignancy ,Small hairpin RNA ,03 medical and health sciences ,0302 clinical medicine ,Drug Discovery ,Genetics ,medicine ,Animals ,Humans ,CRISPR ,Clustered Regularly Interspaced Short Palindromic Repeats ,RNA, Small Interfering ,Molecular Biology ,Cell Proliferation ,Pharmacology ,Cervical cancer ,Human papillomavirus 16 ,Oncogene ,business.industry ,HPV infection ,virus diseases ,medicine.disease ,female genital diseases and pregnancy complications ,Disease Models, Animal ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Nanoparticles ,Molecular Medicine ,Female ,Original Article ,Carcinogenesis ,business - Abstract
Persistent high-risk HPV infection is the main cause of cervical cancer. The HPV oncogene E7 plays an important role in HPV carcinogenesis. Currently, HPV vaccines do not offer an effective treatment for women who already present with cervical disease, and recommended periodical cervical screenings are difficult to perform in countries and areas lacking medical resources. Our aim was to develop nanoparticles (NPs) based on poly (β-amino ester) (PBAE) and HPV16 E7-targeting CRISPR/short hairpin RNA (shRNA) to reduce the levels of HPV16 E7 as a preliminary form of a drug to treat HPV infection and its related cervical malignancy. Our NPs showed low toxicity in cells and mouse organs. By reducing the expression of HPV16 E7, our NPs could inhibit the growth of cervical cancer cells and xenograft tumors in nude mice, and they could reverse the malignant cervical epithelium phenotype in HPV16 transgenic mice. The performance of NPs containing shRNA is better than that of NPs containing CRISPR. HPV-targeting NPs consisting of PBAE and CRISPR/shRNA could potentially be developed as drugs to treat HPV infection and HPV-related cervical malignancy.
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- 2018
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174. Surface Coating of Poly-D-L-Lactide/Nano-Hydroxyapatite Composite Scaffolds for Dexamethasone-Releasing Function and Wettability Enhancement
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Chen, Ling, primary, Tang, Chak Tin, additional, Ku, Harry Siu-Lung, additional, Chen, Da Zhu, additional, and Tsui, Chi Pong, additional
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- 2013
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175. A Novel Treatment for a Han Patient with High Risk of Coronary Obstruction Underwent TAVI Procedure using a Novel Second-Generation Device
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Wang Sheng, Xianjie Chen, Ge Zhenwei, Zhaoyun Cheng, Da Zhu, Duraid Hamied Naji, and Yingqiang Guo
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General Engineering - Published
- 2019
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176. Effects of Ginkgo leaf extract on function of dendritic cells and Th1/Th2 cytokines in patients with unstable angina pectoris
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Li Da-zhu, Sharma Ranjit, and Zeng Qiu-tang
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- 2005
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177. Inhibition of NOS2 ameliorates cardiac remodeling, improves heart function after myocardial infarction in rats
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Zheng, Bin, Cao, Lin-sheng, Zeng, Qiu-tang, Wang, Xiang, Li, Da-zhu, and Liao, Yu-hua
- Published
- 2004
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178. The evolution investigation of photoluminescence from a-Si:H/SiO2 to nc-Si/SiO2 multilayers
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Zhongyuan Ma, Kunji Chen, Xinfan Huang, Wei Li, Jun Xu, Yanping Sui, Da Zhu, Jiaxin Mei, and Duan Feng
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Microstructure -- Research ,Photoluminescence -- Research ,Hydrogen -- Structure ,Hydrogen -- Optical properties ,Silicon compounds -- Structure ,Silicon compounds -- Optical properties ,Oxygen -- Structure ,Oxygen -- Optical properties ,Physics - Abstract
The relation between the evolution of photoluminescence (PL) and microstructure of samples is discussed in detail in this paper. The evolution of PL at room temperature from a-Si:H/SiO2 to nc-Si/SiO2 multilayers was observed through step-by-step post treatment.
- Published
- 2004
179. Nitrogen-doped redox graphene as a negative electrode additive for lead-acid batteries
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Kai-da Zhu, Xin-ru Wang, Jing Zhong, and Sen-lin Wang
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Materials science ,Renewable Energy, Sustainability and the Environment ,Scanning electron microscope ,Graphene ,Oxide ,Energy Engineering and Power Technology ,Ethylenediamine ,Electrochemistry ,Redox ,law.invention ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,law ,Electrode ,Electrical and Electronic Engineering ,Lead–acid battery - Abstract
To suppress the sulfation of the negative electrode of lead-acid batteries, a graphene derivative (GO-EDA) was prepared by ethylenediamine (EDA) functionalized graphene oxide (GO), which was used as an effective additive for the negative electrode of lead-acid batteries. The effect of GO-EDA on the performance of lead-acid batteries was studied by electrochemical methods, simulated cell performance test, X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results show that when the negative active material (NAM) contains 0.5 wt.% GO-EDA additive (the N-0.5 cell), the initial discharge capacity of the cell at a rate of 0.05 C is 171.47 mAh g−1. Meanwhile, the high-rate partial state of charge (HRPSoC) cycle life of the N-0.5 cell under 1 C rate is 17,970 cycles, which is 280% higher than that of the blank control cell. In a word, GO-EDA has the potential to be applied to enhance the specific capacity and HRPSoC cycle-life of lead-acid batteries.
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- 2021
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180. Development of land desertification in Bashang area in the past 20 years
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Zhi-qing, Chen and Zhen-da, Zhu
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- 2001
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181. Study on seismic behavior of simple-connected steel frame with buckling restrained braces
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Fei-Fei, Sun, primary, Guo-Qiang, Li, additional, Su-Wen, Chen, additional, and Da-Zhu, Hu, additional
- Published
- 2009
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182. Thermal effect on the pseudocapacitive behavior of high-performance flexible supercapacitors based on polypyrrole-decorated carbon cloth electrodes
- Author
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Liu, Jia-hua, primary, Xu, Xiao-ying, additional, Liu, Chen, additional, and Chen, Da-Zhu, additional
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- 2021
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183. A new correction method for quasi-Keplerian orbits
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Chen, Yue, primary, Ma, Da-Zhu, additional, and Xia, Fang, additional
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- 2020
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184. Modern Characterization of Electromagnetic Systems and Its Associated Metrology
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Tapan K. Sarkar, Magdalena Salazar-Palma, Ming Da Zhu, Heng Chen, Tapan K. Sarkar, Magdalena Salazar-Palma, Ming Da Zhu, and Heng Chen
- Subjects
- Electromagnetism--Mathematics, Electromagnetic waves--Measurement
- Abstract
New method for the characterization of electromagnetic wave dynamics Modern Characterization of Electromagnetic Systems introduces a new method of characterizing electromagnetic wave dynamics and measurements based on modern computational and digital signal processing techniques. The techniques are described in terms of both principle and practice, so readers understand what they can achieve by utilizing them. Additionally, modern signal processing algorithms are introduced in order to enhance the resolution and extract information from electromagnetic systems, including where it is not currently possible. For example, the author addresses the generation of non-minimum phase or transient response when given amplitude-only data. Presents modern computational concepts in electromagnetic system characterization Describes a solution to the generation of non-minimum phase from amplitude-only data Covers model-based parameter estimation and planar near-field to far-field transformation as well as spherical near-field to far-field transformation Modern Characterization of Electromagnetic Systems is ideal for graduate students, researchers, and professionals working in the area of antenna measurement and design. It introduces and explains a new process related to their work efforts and studies.
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- 2021
185. Use of Computational Electromagnetics to Enhance the Accuracy and Efficiency of Antenna Pattern Measurements
- Author
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Heng Chen, Magdalena Salazar-Palma, Tapan K. Sarkar, and Ming-Da Zhu
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symbols.namesake ,Transformation (function) ,Fourier transform ,Plane (geometry) ,Computer science ,Conjugate gradient method ,Fast Fourier transform ,symbols ,Computational electromagnetics ,Antenna (radio) ,Algorithm ,Radiation pattern - Abstract
The objective of this paper is to illustrate that computational electromagnetics can be used very effectively to improve the accuracy and efficiency of antenna pattern measurements. This is accomplished by moving a single probe over the measurement plane to generate the enhanced accuracy in planar near-field (NF) to far-field (FF) transformation than over the classical Fourier-based modal expansion methods. It is also illustrated that this method provides reliable results for cases when the conventional method fails, particularly, for the case, when the actual source plane and the measurement plane are approximately equal in size. Also, in this approach, there is no need to incorporate probe correction unlike in the existing approaches. In addition, a methodology can be designed where one can use an array of probes instead of moving a single probe over the measurement plane, thus improving the accuracy and efficiency of the measurements. In the use of the probe array, there is also no need to perform the probe correction. This proposed novel methodology is accomplished by solving for the equivalent magnetic current over a plane near the original source antenna under test, and then, employing the method-of-moments (MoM) approach to solve for the equivalent magnetic currents on this fictitious surface. For this proposed methodology, even though, there is no need to satisfy the Nyquist sampling criteria in the measurement plane, a super resolution can be achieved in the solution of the equivalent magnetic current so that one can predict the status of the operation of each antenna elements in an array. Also, the presence of evanescent fields in the measurements does not make this methodology unstable unlike in the conventional Fourier-based techniques. The two components of the equivalent magnetic currents can be solved independently from the two measured components of the electric fields by solving the resultant MoM matrix equation very efficiently and accurately by using the iterative conjugate gradient method enhanced through the incorporation of the fast Fourier transform techniques. Sample numerical results are presented to illustrate the potential of a novel planar NF to FF transformation applied to the planar NF measurement technique.
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- 2018
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186. Damage Analysis of Particulate Polymer Composites Based Structure by Using Micro-Meso-Macro Finite Element Approach
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Tang, Chak Yin, primary, Tsui, Chi Pong, additional, Chen, Da Zhu, additional, Uskoković, P. S., additional, Fan, Jian Ping, additional, Xie, Xiao Lin, additional, and Lee, Eric Wai Ming, additional
- Published
- 2006
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187. Analytical modeling of grinding-induced subsurface damage in monocrystalline silicon
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Hao Nan Li, Li Da Zhu, Wan Shan Wang, and Tian Biao Yu
- Subjects
Grinding process ,0209 industrial biotechnology ,Engineering drawing ,Materials science ,Silicon ,business.industry ,Mechanical Engineering ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Grinding ,Monocrystalline silicon ,020901 industrial engineering & automation ,Semiconductor ,chemistry ,Mechanics of Materials ,Surface roughness ,lcsh:TA401-492 ,Degradation (geology) ,General Materials Science ,lcsh:Materials of engineering and construction. Mechanics of materials ,Profilometer ,Composite material ,0210 nano-technology ,business - Abstract
Monocrystalline silicon is a predominant type of semiconductors. However, subsurface damage (SSD) of silicon has been widely reported during the mechanical grinding process. Although relevant efforts have been reported, most theoretical studies only qualitatively explained the SSD formation mechanism rather than quantitatively evaluate SSD values, while most experimental measurement techniques unavoidably damaged (even destroyed) the ground surfaces and therefore could only be ultilised ex-situ. To fill this gap, this paper suggests an analytical model of grinding-induced SSD in silicon, where the explicit relationship between SSD and the ground surface roughness Rz is analytically established considering the (i) ductile-regime effect, (ii) crystallographic orientation effect, and (iii) material property degradation due to high grinding temperature. Based on the model, grinding-induced SSD could be nondestructively, quickly and conveniently evaluated, in-situ or ex-situ, by measuring Rz values based on a handheld profilometer. Grinding trials indicated the model could accurately evaluate SSD depths along both the 〈100〉 and 〈110〉 crystallographic orientations in both dry and wet silicon grinding processes. Further discussion on how the model could guide and monitor the industrial silicon grinding is also presented. The proposed model therefore is anticipated to be meaningful to facilitate design, manufacture, and applications of monocrystalline silicon. Keywords: Monocrystalline silicon, Grinding, Subsurface damage
- Published
- 2017
188. Detailed modeling of cutting forces in grinding process considering variable stages of grain-workpiece micro interactions
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Tian Biao Yu, Zixuan Wang, Wan Shan Wang, Li Da Zhu, and Hao Nan Li
- Subjects
Grinding process ,0209 industrial biotechnology ,Engineering drawing ,Materials science ,Mechanical Engineering ,Abrasive ,Mechanical engineering ,02 engineering and technology ,Grinding wheel ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Rubbing ,Grinding ,Variable (computer science) ,020901 industrial engineering & automation ,Mechanics of Materials ,Cutting force ,Miniaturization ,General Materials Science ,0210 nano-technology ,Civil and Structural Engineering - Abstract
Grinding forces are a key parameter in the grinding process, most previous studies on grinding forces, however, (i) were regardless of grain-workpiece micro interaction statuses and (ii) could only predict average/maximal grinding forces based on average/maximal cutting depths or chip thicknesses. In this study, a novel detailed modeling methodology of grinding forces has been analytically established, experimentally validated and utilised to study a specific issue that previous methods can not address. Based on the proposed method, grinding forces with detailed information (e.g. three components including rubbing, plowing and cutting forces) could be accurately predicted. Except for grinding forces, the proposed methodology also enable the availability of other grinding process details at the grain scale (e.g. the ratios of grains that are experiencing rubbing, plowing and cutting stages to the total engaging grain number). Validation experiment results have proved that, the proposed method could, to a large extent, describe the realistic grinding forces. Based on the proposed method, the effects of grinding conditions (including depths of cut, wheel speeds, workpiece feed speeds and grinding wheel abrasive sizes) on each component of grinding forces (rubbing, plowing, and cutting forces) have been analyzed. Some new findings, which could enhance the existing understandings of grinding forces and guide industrial manufacture, have been gained. The proposed method therefore is anticipated to be not only meaningful to provide a new way to model grinding forces in detail, but also promising to study other grinding issues (e.g. grinding heat, machined surface topography, grinding chatter), especially under the trend of miniaturization and microfabrication where grinding details at the grain scale are highly needed to optimise the micro grinding tool efficiency and micro-grinding accuracy.
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- 2017
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189. The orbital configuration of the two interacting Jupiters in HD 155358 system
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Yanning Fu, Da-Zhu Ma, and Xiao-Li Wang
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Physics ,010308 nuclear & particles physics ,Apsidal precession ,media_common.quotation_subject ,Astronomy and Astrophysics ,Astrophysics ,Planetary system ,Orbital decay ,01 natural sciences ,Resonance (particle physics) ,Mean motion ,Space and Planetary Science ,Planet ,0103 physical sciences ,Astrophysics::Earth and Planetary Astrophysics ,Eccentricity (behavior) ,Adiabatic process ,010303 astronomy & astrophysics ,media_common - Abstract
Recent observation reveals two interacting Jupiters possibly trapped in a 2: 1 mean motion resonance (MMR) around the star HD 155358. For the 2:1 MMR, Beauge et al. found that as long as the orbital decay was sufficiently slow, the trapped planets should also be in apsidal co-rotation. So it is very interesting to explore whether HD 155358 did undergo such an evolution and presents an apsidal co-rotation. Based on the existing results of spectroscopic orbital determination, the global dynamics of the system shows that the two planets are in an apsidal co-rotation if the eccentricity of the outer planet (ec) takes values very close to the lower limit of its 1 sigma confidence interval. This makes us conjecture that the globally minimizing solution could be missed in the previous orbital determination. Using an efficient global optimization method, we do find a better solution, reducing chi(2) from 1.4 to 1.2. This new solution is significantly different from the previous one, and in particular, with smaller ec. However, the increased possibility for the system to be trapped in a 2: 1 MMR with apsidal co-rotation is still not high. A set of simulations of the adiabatic convergent migration process are then performed. The results consistently indicate that the 2: 1 MMR forms before apsidal co-rotation. Finally, the long-term stability of the formed system and of its resonant structure is extensively explored, and the resulting statistics are given. A conclusion is that the 2: 1 MMR with apsidal co-rotation is a very stable structure.
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- 2017
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190. C-Reactive Protein Levels and Survival Following Cytoreductive Nephrectomy in 118 Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib: A Retrospective Study
- Author
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Da Zhu Huo, Wenhao Xu, Hai Liang Zhang, Dingwei Ye, Guo Hai Shi, Guo Cai Yin, Da Long Cao, Yuan-Yuan Qu, and Jun Wang
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,Indoles ,medicine.medical_treatment ,Antineoplastic Agents ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Gastroenterology ,Nephrectomy ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Clinical Research ,Internal medicine ,medicine ,Carcinoma ,Sunitinib ,Humans ,Pyrroles ,Progression-free survival ,Carcinoma, Renal Cell ,Aged ,Proportional Hazards Models ,Retrospective Studies ,biology ,Proportional hazards model ,business.industry ,C-reactive protein ,Retrospective cohort study ,General Medicine ,Cytoreduction Surgical Procedures ,Middle Aged ,medicine.disease ,Prognosis ,Kidney Neoplasms ,Progression-Free Survival ,C-Reactive Protein ,Treatment Outcome ,030220 oncology & carcinogenesis ,biology.protein ,Female ,business ,medicine.drug - Abstract
BACKGROUND This study aimed to evaluate the factors associated with a survival benefit for patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib, with and without cytoreductive nephrectomy (CN). MATERIAL AND METHODS This retrospective clinical study included 118 patients with mRCC who were treated with CN and sunitinib (CN-sunitinib) (N=70) and with sunitinib-alone (N=48). Categorical clinicopathological variables were compared with hypothesis tests using contingency tables and a chi-squared test. Independent indicators for progression-free survival (PFS) and overall survival (OS) were analyzed with univariate and multivariate Cox regression models. The Kaplan-Meier method and log-rank test were used to evaluate patient survival. RESULTS The median PFS and OS for the 118 patients were 8.38 and 15.48 months, respectively. There were no significant differences between the CN-sunitinib group and the sunitinib-alone group for either PFS (7.2 months vs. 11.6 months; P=0.525) or OS (16.7 months vs. 15.2 months; P=0.839). Stratification of patients based on clinicopathological characteristics showed that CN was significantly associated with reduced PFS and OS for patients with lymph node metastasis (PFS, P
- Published
- 2019
191. Effective Reservoir Management with Flow Control Devices for SAGD Producer Wells in Mackay River
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Dermot O'Hagan, Giuseppe Rosi, and Da Zhu
- Subjects
Flow control (fluid) ,Petroleum engineering ,020209 energy ,0202 electrical engineering, electronic engineering, information engineering ,Reservoir management ,Production optimization ,Environmental science ,02 engineering and technology - Abstract
Inflow Control Devices (ICDs) have been adopted for commercial steam-assisted gravity drainage (SAGD) production for nearly ten years and yet the function they serve is not well understood, and field data evaluating their performance remains scant. Thus, the purpose of the current study is twofold: Firstly, the study derives a simplified analytical model demonstrating how increasing the dP across ICDs acts to improve conformance along a producing lateral. The resulting equation of the analysis acts as a simple rule of thumb for determining an appropriate pressure drop across ICDs to achieve conformance. Secondly, the study evaluates the performance of ICDs that had been installed in four wells, two of which had ICDs installed prior to circulation and two that adopted ICDs later in their lifecycle. The field data shows that ICDs increase production rates and improve conformance along the lateral. These improvements are achieved by an increased drawdown facilitated by the ICDs. This part of the study highlights how early-life results may differ between ICD bearing wells compared to their conventionally completed (slotted liner) offsets: ICD bearing wells exhibit improved conformance and an ability to develop more challenging reservoir resulting in different oil production profiles and composite SORs.
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- 2019
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192. Advancing the CFD Simulation of Flashing in Inflow Control Devices
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Lei Li, Tarek H. Nigim, Carlos F. Lange, and Da Zhu
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Cfd simulation ,Materials science ,business.industry ,020209 energy ,02 engineering and technology ,Inflow ,Computational fluid dynamics ,Flashing ,01 natural sciences ,010305 fluids & plasmas ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,business ,Marine engineering - Abstract
Flashing flow is a common phenomenon in many industrial applications and, in steam-assisted gravity drainage (SAGD), it is considered a significant process. Flashing may occur if there is a sudden pressure drop in the production well in SAGD, which is a typical in-situ way to extract heavy oil from tar sands. This may change the expected pressure drop across inflow control devices (ICDs), which are the controllers installed within the production well. Flashing is defined as self-boiling of a liquid due to a reduction of pressure, and it is a complex, multiphase flow phenomenon. The main objectives of the present work are to develop and to validate a multiphase computational model that has the ability to predict the thermo-fluid behaviour of the flow during the flashing process inside ICD nozzles, and to assess its effect on the pressure distribution through ICDs in a predictive way. Our computational model is applied to time-averaged, two-phase, adiabatic, turbulent flows. The new computational model can predict the phase changes between liquid and vapour phases based on mechanical effects (pressure). This is achieved by comparing the local pressure in each computational cell with the local vapour pressure. Considering the thermo-fluid complexity together in one model gives such a simulation the potential to be invaluable for a better understanding of roles of the combined mass transfer and the flashing dynamics during the flashing flow process, and to be applied as an industrial inflow control device to choke back steam for SAGD production system. It may assist in obtaining insight and information where measurements would be difficult. Furthermore, the CFD results can be used to generate compact predictive functions of pressure drop within ICDs, and to investigate the effects of both non-condensable gases and solvents in ICDs performance.
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- 2019
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193. Options for the treatment of intrahepatic recurrent hepatocellular carcinoma: Salvage liver transplantation or rehepatectomy?
- Author
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Jiong-Ze Fang, Cai-De Lu, Yangke Hu, Hong-Da Zhu, Li Xiang, and Yong Yang
- Subjects
Salvage Therapy ,Transplantation ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,genetic structures ,business.industry ,medicine.medical_treatment ,Liver Neoplasms ,030230 surgery ,Liver transplantation ,Gastroenterology ,Recurrent Hepatocellular Carcinoma ,Liver Transplantation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Overall survival ,Medicine ,Hepatectomy ,Humans ,030211 gastroenterology & hepatology ,Neoplasm Recurrence, Local ,business ,Retrospective Studies - Abstract
OBJECTIVE To explore prognostic factors by comparing the efficacy of salvage liver transplantation (sLT) and rehepatectomy (RH) for the treatment of recurrent hepatocellular carcinoma after hepatectomy. METHODS Clinical data were collected for 124 patients treated at our center from January 2012 to August 2018. The median follow-up time for the patients was 39 months. By analyzing the clinical data between the sLT group (46 cases) and RH group (78 cases), the factors affecting the prognosis of patients were compared. RESULTS The proportion of alpha-fetoprotein (AFP) ≥ 100 µg/L in the recurrence group was significantly higher than that in the recurrence-free group (70.0% vs 22.2%, P = .014). The postoperative overall survival (OS) and recurrence-free survival (RFS) were better in the sLT group than in the RH group (81.2% vs 36.9%, P
- Published
- 2019
194. A Stabilized Solution of Time-Domain Combined Field Integral Equation using Associated Laguerre Functions
- Author
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Xunwang Zhao, Yu Zhang, and Ming-Da Zhu
- Subjects
Laguerre polynomials ,Applied mathematics ,Initial value problem ,Degree of a polynomial ,Time domain ,Galerkin method ,Integral equation ,Mathematics ,Numerical stability ,Quadrature (mathematics) - Abstract
The time domain integral equation (TDIE) using associated Laguerre functions [1] is one of the promising transient and broadband computational electromagnetic methods. It is a marching-on-in-degree (MOD) method for solving various electromagnetic compatibility and electromagnetic interference (EMC & EMI) problems. Over the past decades, the instability of time-domain integral equation remains one of the main obstacles to improve the quality of the TDIE solutions. The MOD method adopts the associated Laguerre functions as temporal basis functions. As the associated Laguerre polynomials decays exponentially in time, the MOD scheme is immune to the late-time unstable behavior of marching-on-in-time methods (MOT). Although the MOD solver is assumed to be stable, there still exists an instabilty when the TDIE-MOD scheme marches on to very high degree of the Laguerre polynomials [2]. The main reason is that MOD iterates with respect to the polynomial degrees rather than the time steps. The instability related to the MOD solution of time-domain magnetic field integral equation (TD-MFIE-MOD) and time-domain electric integral equation (TD-EFIE-MOD) are eliminated by a Filon-type quadrature for associated Laguerre polynomials, and a novel Filon-type radial integration method for oscillatory quadrature on triangular patches, which are proposed in [2], [3]. On the other hand, the exact temporal Galerkin testing procedure in the MOD solution is affected by an unbounded initial value of the transient current density, which allows numerical errors to accumulate and affect the ultimate stability. Therefore, a sequential constraint term needs to be added without destroying the causality of the MOD method.
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- 2019
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195. Optimal oral anticoagulant therapy in Chinese patients with mechanical heart valves
- Author
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Heng Zhang, Xuelian Ao, Yijun Dong, Li Dong, and Da Zhu
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,medicine.drug_class ,medicine.medical_treatment ,Pharmaceutical Science ,Administration, Oral ,Hemorrhage ,02 engineering and technology ,030226 pharmacology & pharmacy ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Aortic valve replacement ,Thromboembolism ,Clinical endpoint ,Medicine ,Humans ,Adverse effect ,Aged ,Aged, 80 and over ,business.industry ,Incidence (epidemiology) ,Anticoagulant ,Mitral valve replacement ,Anticoagulants ,Middle Aged ,021001 nanoscience & nanotechnology ,medicine.disease ,Surgery ,Regimen ,Heart Valve Prosthesis ,Female ,0210 nano-technology ,business ,Cohort study ,Follow-Up Studies - Abstract
Background: The oral administration of anticoagulants is an effective means of preventing thromboembolic complications in patients implanted with mechanical valves. This treatment strategy, however, entails a dose-dependent in the risk of hemorrhage that is a cause for concern in China. As such, in this study, we sought to better determine what the ideal oral anticoagulant therapy intensity is in a Chinese population of patients implanted with mechanical valves. Methods: In the present observational cohort study, we observed the outcomes of eligible enrolled patients that had been implanted with St. Jude Medical prosthetic valves and who had been treated at our institution from 2013 onwards. All enrolled patients were followed for between 1 and 6 years through outpatient visits or telephone interviews following discharge. Study endpoints included instances of thromboembolism and major hemorrhage. We calculated the international normalized ratio (INR)-specific incidence of such adverse events as a means of determining optimal anticoagulant therapeutic intensity in patients with these bileaflet mechanical valve prostheses. Results: In total this study enrolled 3176 patients, of whom 3017 were followed for 12,746.08 total person-years (4.22 mean years per patient), while the remaining 159 patients (5%) were lost during follow-up. A total of 182 patients suffered from adverse events, with a roughly 1.43% annual incidence rate of such adverse events (95% confidence interval [CI], 1.22–1.64). Of these, 54 patients suffered from episodes of major bleeding (0.42% per patient-year, 95% CI, 0.31–0.53), while 131 suffered from thromboembolism (1.03% per patient-year, 95% CI, 0.85–1.21). Based on these analyses, we determined that the ideal low-intensity anticoagulant treatment regimen for patients with bileaflet mechanical heart valve prostheses was an INR between 1.5 and 2.5. In those patients that had undergone aortic valve replacement (AVR), the optimal INR was between 1.5 and 2.0 regardless of any thromboembolism risk factors in these patients. In contrast, in patients that had undergone mitral valve replacement (MVR) who were not at risk for thromboembolism, the optimal INR was between 1.5 and 2.0, whereas in those at risk of thromboembolism the optimal INR was between 2.0 and 2.5. The ideal anticoagulant intensity in patients undergoing both AVR and MVR (DVR) was the same as in patients undergoing MVR alone. Conclusions: In order to achieve optimal outcomes by maintaining effective anticoagulant dosing while entailing minimal risk in Chinese patients that have undergone a bileaflet mechanical valve replacement, the target INR range should be between 1.5 and 2.5, with the final intensity of this anticoagulant regimen being determined based on a given patient's risk of thromboembolism.
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- 2019
196. Extrapolation of Antenna Near-Field Measurements Using the Iterative Greedy Algorithms
- Author
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Yu Zhang, Tapan K. Sarkar, and Ming-Da Zhu
- Subjects
Transformation (function) ,Computer science ,Antenna measurement ,0202 electrical engineering, electronic engineering, information engineering ,Extrapolation ,020206 networking & telecommunications ,Basis function ,Near and far field ,02 engineering and technology ,Antenna (radio) ,Missing data ,Greedy algorithm ,Algorithm - Abstract
There are often missing gaps in the antenna near-field measurements, due to various physical limitations. However, the missing data are indispensable if we want to accurately evaluate the complete far-field pattern by the near-field to far-field transformations. To address this problem, a fast extrapolation method based on the iterative greedy algorithm is proposed to reconstruct the missing part of antenna near-field measurements in this paper. The near-field data is approximated by sparse signals with the Fourier basis, which is recoverable by the greedy pursuits. As the near-field data in this paper is obtained on the spherical measurement surface, the far field of the antenna is calculated by the spherical near-field to far-field transformation with the extrapolated data. Some numerical results are given to demonstrate the applicability of the proposed scheme in extrapolating antenna near-field measurements.
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- 2019
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197. A Stabilized Marching-on-in-Degree Solution of Time Domain Combined Field Integral Equation
- Author
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Ming-Da Zhu, Yu Zhang, and Tapan K. Sarkar
- Subjects
Field (physics) ,Domain (ring theory) ,0202 electrical engineering, electronic engineering, information engineering ,Laguerre polynomials ,Applied mathematics ,020206 networking & telecommunications ,02 engineering and technology ,Time domain ,Solver ,Integral equation ,Instability ,Quadrature (mathematics) ,Mathematics - Abstract
The instability problem of time domain integral equation (TDIE) remains one of the key obstacles to improve the quality of the TDIE solvers over the past decades. In this paper, the stabilized marching-on-in-degree (MOD) method of time-domain combined field integral equation (TD-CFIE-SMOD) is presented in solution of transient scattering problems. The instability problem of TDIE-MOD is primarily caused by the oscillatory nature of the Laguerre functions. Therefore, the Filon-type quadrature for excitation integrals and the Filon-type radial integration method on triangular domains is adopted in the TD-CFIE-SMOD solver. Some numerical results are presented to show the validity of the proposed solution of TD-CFIE using the current methodology.
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- 2019
- Full Text
- View/download PDF
198. Research on Multi-stage Noise Reduction Method of NMR Logging Signal
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Na Liu, Dai-gang Yang, Yun-feng Bai, Ming-da Zhu, Yao-yi Guo, and Hua Gao
- Subjects
Multi stage ,Wavelet ,Finite impulse response ,Computer science ,Noise reduction ,Echo signal ,Fluid type ,Inversion (meteorology) ,Hardware_ARITHMETICANDLOGICSTRUCTURES ,Algorithm - Abstract
By inversion calculation of T2 spectrum of echo string, the permeability, saturation, fluid type and other important parameters of porous media can be obtained. However, since the inversion algorithm itself is susceptible to noise signal [1], improving the SNR level of echo signal has been one of the key problems in the application of low-field NMR technology. In order to obtain more accurate analysis results, the corresponding noise reduction method needs to be developed. In the past, the research on noise reduction of NMR signal mainly focused on echo string. This paper constructs a complete NMR signal model and discusses the de-noising of echo and echo string. Aiming at noise reduction of echo, FIR filter and Orthogonal Modulation Filter(OMF) are discussed. Aiming at the de-noising of echo string, this paper proposes an improved CEEMD threshold de-noising, and makes a comparative analysis with the heuristic threshold de-noising based on sym4 wavelet and EMD threshold de-noising proposed by predecessors. It is found that the method proposed in this paper can invert the more accurate T2 spectrum while improving the SNR.
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- 2019
- Full Text
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199. Long non-coding RNA CCAT1 promotes cervical cancer cell proliferation and invasion by regulating the miR-181a-5p/MMP14 axis
- Author
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Wencheng Ding, Ci Ren, Ding Ma, Da Zhu, Liming Wang, Chun Gao, Hui Wang, Hui Shen, and Jinfeng Xiong
- Subjects
0301 basic medicine ,Uterine Cervical Neoplasms ,Biology ,Malignancy ,03 medical and health sciences ,0302 clinical medicine ,microRNA ,Cervical carcinoma ,medicine ,Matrix Metalloproteinase 14 ,Humans ,Neoplasm Invasiveness ,Molecular Biology ,Cell Proliferation ,Cervical cancer ,RNA ,Correction ,Cell Biology ,medicine.disease ,In vitro ,Long non-coding RNA ,Up-Regulation ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,MMP14 ,Female ,RNA, Long Noncoding ,Developmental Biology - Abstract
Cervical cancer is a serious threat to women's health and is the third most common malignancy in women worldwide. Recent studies indicate that the long non-coding RNA CCAT1 plays a role in the malignant behavior of many tumors. However, the role of CCAT1 in cervical cancer is still unknown. Our aim is to evaluate the expression and investigate the regulatory role and potential mechanism of CCAT1 in cervical cancer. CCAT1 expression was measured by qRT-PCR. In addition, CCK-8 assays, colony formation assays, qRT-PCR assays, Transwell assays and xenograft experiments were performed to determine the role of CCAT1 in the proliferation and invasion in cervical cancer cells. The expression of CCAT1 in the cervical cancer tissues was higher than in the adjacent normal tissues. Overexpressing CCAT1 promoted cervical cancer cell proliferation, colony formation, and invasion in vitro. Elevated CCAT1 suppressed miR-181a expression, which was accompanied by an increased expression of MMP14 and HB-EGF. In contrast, knocking down CCAT1 resulted in increased expression of miR-181a, along with decreased expression of MMP14 and HB-EGF. Thus, CCAT1 is a key oncogenic lncRNA associated with cervical cancer and plays a role in promoting cervical cancer cell proliferation and invasion by regulating the miR-181a-5p/MMP14 axis.
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- 2019
200. Systems Chemical Genetics-Based Drug Discovery: Prioritizing Agents Targeting Multiple/Reliable Disease-Associated Genes as Drug Candidates
- Author
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Zhi-Hui Luo, Yan-Hua Xu, Li-Da Zhu, Jiang Li, Qiang Zhu, Ye-Mao Liu, Hong-Yu Zhang, Qingyong Yang, Xuan Qin, Yuan Quan, Ze-Jia Cui, and Bo-Min Lv
- Subjects
0301 basic medicine ,Drug ,lcsh:QH426-470 ,media_common.quotation_subject ,Druggability ,Disease ,Computational biology ,Biology ,drug discovery ,03 medical and health sciences ,0302 clinical medicine ,drug targets ,Genetics ,Gene ,Genetics (clinical) ,media_common ,Original Research ,Disease gene ,Drug discovery ,Pathogenic factor ,lcsh:Genetics ,030104 developmental biology ,disease associated genes ,machine learning ,030220 oncology & carcinogenesis ,systems chemical genetics ,Molecular Medicine ,Chemical genetics - Abstract
Genetic disease genes are considered a promising source of drug targets. Most diseases are caused by more than one pathogenic factor; thus, it is reasonable to consider that chemical agents targeting multiple disease genes are more likely to have desired activities. This is supported by a comprehensive analysis on the relationships between agent activity/druggability and target genetic characteristics. The therapeutic potential of agents increases steadily with increasing number of targeted disease genes, and can be further enhanced by strengthened genetic links between targets and diseases. By using the multi-label classification models for genetics-based drug activity prediction, we provide universal tools for prioritizing drug candidates. All of the documented data and the machine-learning prediction service are available at SCG-Drug (http://zhanglab.hzau.edu.cn/scgdrug).
- Published
- 2019
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