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Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamació; Mediadors d'inflamació Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamación; Mediadores de la inflamación Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflammation; Inflammation mediators Background Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by cancer progression and COVID-19. We investigated systemic inflammation as a driver of severity and mortality from COVID-19, evaluating the prognostic role of commonly used inflammatory indices in SARS-CoV-2-infected patients with cancer accrued to the OnCovid study. Methods In a multicenter cohort of SARS-CoV-2-infected patients with cancer in Europe, we evaluated dynamic changes in neutrophil:lymphocyte ratio (NLR); platelet:lymphocyte ratio (PLR); Prognostic Nutritional Index (PNI), renamed the OnCovid Inflammatory Score (OIS); modified Glasgow Prognostic Score (mGPS); and Prognostic Index (PI) in relation to oncological and COVID-19 infection features, testing their prognostic potential in independent training (n=529) and validation (n=542) sets. Results We evaluated 1071 eligible patients, of which 625 (58.3%) were men, and 420 were patients with malignancy in advanced stage (39.2%), most commonly genitourinary (n=216, 20.2%). 844 (78.8%) had ≥1 comorbidity and 754 (70.4%) had ≥1 COVID-19 complication. NLR, OIS, and mGPS worsened at COVID-19 diagnosis compared with pre-COVID-19 measurement (p

The trend of digitizing analogue artefacts from cultural heritage collections to create cultural digital items remains ongoing. The user experience of Cultural Heritage Practitioners (CHP) should be understood in order to support academic efforts in producing practical contributions that benefit those working with cultural digital items. In this publication we follow a series of semi-structured interviews with 10 CHPs and supporting technical professionals who work with cultural digital items on a daily basis. We then code their responses for theme, analysing their thoughts and concerns regarding key topics connected to cultural digital items such as interactivity and the challenges of digitization within the culture heritage sector., Eurographics Workshop on Graphics and Cultural Heritage, Engaging with Cultural Heritage, 1, 9, Christopher Ferraris, Christos Gatzidis, Tom Davis, and Charlie Hargood, CCS Concepts: Human-centered computing --> Human computer interaction (HCI); Social and professional topics --> Cultural characteristics

BACKGROUND: Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients with cancer in the UK. METHODS: We compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project (UKCCMP) cohort between March 18 and May 8, 2020, with a parallel non-COVID-19 UK cancer control population from the UK Office for National Statistics (2017 data). The primary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence and the case-fatality rate during hospital admission. We analysed the effect of tumour subtype and patient demographics (age and sex) on prevalence and mortality from COVID-19 using univariable and multivariable models. FINDINGS: 319 (30·6%) of 1044 patients in the UKCCMP cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case-fatality rate in patients with cancer after SARS-CoV-2 infection was significantly associated with increasing age, rising from 0·10 in patients aged 40-49 years to 0·48 in those aged 80 years and older. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours (odds ratio [OR] 1·57, 95% CI 1·15-2·15; p

Whilst there is a large body of NIME papers that concentrate on the presentation of new technologies there are fewer papers that have focused on a longitudinal understanding of NIMEs in practice. This paper embodies the more recent acknowledgement of the importance of practice-based methods of evaluation [1,2,3,4] concerning the use of NIMEs within performance and the recognition that it is only within the situation of practice that the context is available to actually interpret and evaluate the instrument [2]. Within this context this paper revisits the Feral Cello performance system that was first presented at NIME 2017 [5]. This paper explores what has been learned through the artistic practice of performing and workshopping in this context by drawing heavily on the experiences of the performer/composer who has become an integral part of this project and co-author of this paper. The original philosophical context is also revisited and reflections are made on the tensions between this position and the need to ‘get something to work’. The authors feel the presentation of the semi-structured interview within the paper is the best method of staying truthful to Hayes understanding of musical improvisation as an enactive framework ‘in its ability to demonstrate the importance of participatory, relational, emergent, and embodied musical activities and processes’ [4].

Este artículo contiene 14 páginas, 7 figuras., Reef Life Survey (RLS) provides a new model for ecological monitoring through training experienced recreational divers in underwater visual census methods to the level of skilled scientists. Detail produced is similar to that of programs with professional scientific teams, at low cost to allow global coverage. RLS differs from most other citizen science initiatives in its emphasis on rigorous training and data quality rather than open participation, selectively involving the most skilled and committed members. Volunteers participate primarily because they appreciate the close relationship with scientists, other divers, and managers, and see their efforts directly contributing to improved environmental outcomes. RLS works closely with Australian management agencies, scheduling annual events at core monitoring sites associated with 10 inshore marine protected areas Australiawide. Surveys of 12 offshore Australian Marine Parks (AMPs) are realized through 2–4 week voyages in a sailing catamaran crewed by volunteers. Across the AMP network, RLS surveys have quantified densities of fishes, mobile invertebrates, macroalgae and corals at 350 shallow coral reef sites (180 sites surveyed on two or more occasions), providing an understanding of (i) population changes amongst threatened species including sea snakes, (ii) responses of fish and invertebrate populations following fisheries closures, (iii) ecosystem-wide impacts of marine heat-waves, and (iv) the extent that AMPs spanning the network comprehensively encompass national coral reef biodiversity. This scientist/volunteer/manager collaboration could be greatly expanded globally (presently 3537 sites in 53 countries)., Reef Life Survey Foundation has been sustained through grants from the Ian Potter Foundation and Minderoo Foundation, reporting contracts from Parks Australia, and administrative and analytical support from the University of Tasmania. The RLS program was established through a grant to GJE through the former Commonwealth Environment Research Facilities Program. Analyses were supported by the Australian Research Council and the Marine Biodiversity Hub, a collaborative partnership supported through the Australian Government’s National Environmental Science Program. Additional advice and assistance have been provided by the Department for Environment and Water (South Australia), Department of Primary Industries, Parks, Water and Environment (Tasmania), Department of Primary Industries (New South Wales), Department of Biodiversity, Conservation and Attractions (Western Australia), and Parks Victoria. Data management and distribution is supported through the Integrated Marine Observing System.