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1,016 results on '"Cui, Qinghua"'

154. Additional file 1 of smORFunction: a tool for predicting functions of small open reading frames and microproteins

Author

Xiangwen Ji, Chunmei Cui, and Cui, Qinghua

Abstract

Additional file 1: Figure S1. The function prediction of Mm47 using its similar microprotein. (a) The alignment between Mm47 and smORF at chr7: 135358848–135358913 (+) using BLAST protein (BLASTp). (b) The prediction of gene ontology cellular components of the similar microprotein. Related terms were marked in red. FDRs were calculated using Benjamini–Hochberg procedure.

Published
2020
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157. Harmine alleviates atherogenesis by inhibiting disturbed flow‐mediated endothelial activation via protein tyrosine phosphatase PTPN14 and YAP

Author

Yang, Yujie, primary, Ma, Qiannan, additional, Li, Zhiyu, additional, Wang, Hui, additional, Zhang, Chenghu, additional, Liu, Yajin, additional, Li, Bochuan, additional, Wang, Yingmei, additional, Cui, Qinghua, additional, Xue, Fengxia, additional, Ai, Ding, additional, Zhu, Yi, additional, and He, Jinlong, additional

Published
2021
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165. Sodium rutin extends lifespan and health span in mice including positive impacts on liver health.

Author

Li, Shuoshuo, Li, Jun, Pan, Ruiyuan, Cheng, Jinbo, Cui, Qinghua, Chen, Jianxin, and Yuan, Zengqiang

Abstract

Background and Purpose: Ageing is associated with progressive metabolic dysregulation. Rutin is a metabolic regulator with a poor solubility. Using soluble sodium rutin we investigating the effect and mechanisms of rutin in ageing process. Experimental Approach Wild type male mice were treated with or without sodium rutin (0.2 mg·ml−1 in drinking water from 8‐month‐old until end of life. Kaplan–Meier survival curve was used for lifespan assay, ageing‐related histopathology analysis and metabolic analysis were performed to determine the effects of chronic sodium rutin on the longevity. Serological test, liver tissue metabolomics and transcriptomics were used for liver function assay. SiRNA knockdown Angptl8 and autophagy flux assay in HepG2 cell lines explored the mechanism through which sodium rutin might impact the function of hepatocyte. Key Results: Sodium rutin treatment extends the lifespan of mice by 10%. Sodium rutin supplementation alleviates ageing‐related pathological changes and promotes behaviour performance in ageing mice. Sodium rutin supplementation altered the whole‐body metabolism in mice, which exhibited increased energy expenditure and lower respiratory quotient. Transcriptomics analysis showed that Sodium rutin affected the expression of metabolic genes. Metabolomics analysis showed that Sodium rutin reduced liver steatosis through increased lipid β‐oxidation. Sodium rutin treatment increased the autophagy level both in vivo and in vitro. The inhibition of autophagy partially abolished the sodium rutin‐mediated effect on lipolysis in HepG2 cells. Conclusion and Implications: Sodium rutin treatment extends the lifespan and health span of mice with beneficial effects on metabolism, which were achieved by enhancing the autophagy activity in hepatocytes. LINKED ARTICLES: This article is part of a themed issue on Inflammation, Repair and Ageing. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.9/issuetoc [ABSTRACT FROM AUTHOR]

Published
2022
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171. CD4 + T-Cell Endogenous Cystathionine γ Lyase–Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation

Author

Cui, Changting, primary, Fan, Jinghui, additional, Zeng, Qiang, additional, Cai, Junyan, additional, Chen, Yongzeng, additional, Chen, Zhenzhen, additional, Wang, Wenjie, additional, Li, Shuang yue, additional, Cui, Qinghua, additional, Yang, Jichun, additional, Tang, Chaoshu, additional, Xu, Guoheng, additional, Cai, Jun, additional, and Geng, Bin, additional

Published
2020
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174. Punicalagin is a neuraminidase inhibitor of influenza viruses

Author

Li, Ping, primary, Du, Ruikun, additional, Chen, Zinuo, additional, Wang, Yanyan, additional, Zhan, Peng, additional, Liu, Xinyong, additional, Kang, Dongwei, additional, Chen, Zhaoyu, additional, Zhao, Xiujuan, additional, Wang, Lin, additional, Rong, Lijun, additional, and Cui, Qinghua, additional

Published
2020
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175. Cold-inducible Klf9 regulates thermogenesis of brown and beige fat

Author

Admin, Ada, primary, Fan, Heng, primary, Zhang, Yujie, primary, Zhang, Jun, primary, Yao, Qiyuan, primary, Song, Yongfeng, primary, Shen, Qiwei, primary, Lin, Jun, primary, Gao, Yuanxu, primary, Wang, Xiuyun, primary, Zhang, Lei, primary, Zhang, Yinliang, primary, Liu, Pingsheng, primary, Zhao, Jiajun, primary, Cui, Qinghua, primary, Li, John Zhong, primary, and Chang, Yongsheng, primary

Published
2020
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176. Cold-Inducible Klf9 Regulates Thermogenesis of Brown and Beige Fat

Author

Fan, Heng, primary, Zhang, Yujie, additional, Zhang, Jun, additional, Yao, Qiyuan, additional, Song, Yongfeng, additional, Shen, Qiwei, additional, Lin, Jun, additional, Gao, Yuanxu, additional, Wang, Xiuyun, additional, Zhang, Lei, additional, Zhang, Yinliang, additional, Liu, Pingsheng, additional, Zhao, Jiajun, additional, Cui, Qinghua, additional, Li, John Zhong, additional, and Chang, Yongsheng, additional

Published
2020
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