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153. Interconnect-Free Multibit Arithmetic and Logic Unit in a Single Reconfigurable 3 μm2 Plasmonic Cavity

Author

Erik Dujardin, Raminfar Al Rafrafin, Florian Dell'Ova, Raffaele Mezzenga, Sreenath Bolisetty, Gérard Colas des Francs, Alexandre Bouhelier, Aurélien Cuche, Christian Girard, Upkar Kumar, Sviatlana Viarbitskaya, Groupe NanoSciences (CEMES-GNS), Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS), Department of Health Sciences and Technology [ETH Zürich] (D-HEST), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), This work has been funded by the French Agence Nationale de la Recherche (ANR-13-BS10-0007-PLACORE), the European Research Council (ERC-2007-StG-203872-COMOSYEL), the Region of Burgundy (PARI II Photcom), the EIPHI graduate school (ANR-17-EUR-0002), the Conseil Régional de Bourgogne-Franche-Comté (APEX), and the European Regional Developement Fund (Project Optiflex). The authors acknowledge the support of the massively parallel computing center CALMIP (Toulouse, Fr) through Project No. P1107., ANR-13-BS10-0007,PlaCoRe,Circuits Plasmoniques Colloidaux Reconfigurables(2013), ANR-17-EURE-0002,EIPHI,Ingénierie et Innovation par les sciences physiques, les savoir-faire technologiques et l'interdisciplinarité(2017), European Project, Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), and Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adder, Computer science, Clock rate, General Physics and Astronomy, 02 engineering and technology, Integrated circuit, plasmonics, law.invention, 03 medical and health sciences, law, General Materials Science, Arithmetic, Hardware_ARITHMETICANDLOGICSTRUCTURES, 030304 developmental biology, Electronic circuit, 0303 health sciences, Interconnection, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], reconfigurable device, General Engineering, Control reconfiguration, Interconnect bottleneck, nonlinear photoluminescence, 021001 nanoscience & nanotechnology, cavity modes, Logic gate, logic gates, half-adder, 0210 nano-technology, Hardware_LOGICDESIGN
Abstract

International audience; Processing information with conventional integrated circuits remains beset by the interconnect bottleneck: circuits made of smaller active devices need longer and narrower interconnects, which have become the prime source of power dissipation and clock rate saturation. Optical interchip communication provides a fast and energy-saving option that still misses a generic on-chip optical information processing by interconnect-free and reconfigurable Boolean arithmetic logic units (ALU). Considering metal plasmons as a platform with dual optical and electronic compatibilities, we forge interconnect-free, ultracompact plasmonic Boolean logic gates and reconfigure them, at will, into computing ALU without any redesign nor cascaded circuitry. We tailor the plasmon mode landscape of a single 2.6 μm2 planar gold cavity and demonstrate the operation and facile reconfiguration of all 2-input logic gates. The potential for higher complexity of the same logic unit is shown by a multi-input excitation and a phase control to realize an arithmetic 2-bit adder.

Published
2021
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154. Late-onset and nonlate-onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Author

Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chene, D., Rauzy, A., Reinheimer, L., Renard, M., Rene, M., Rengade, C. E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J. P., Samuelian, J. C., Scemama-Ammar, C., Schurhoff, F., Schuster, J. P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A. S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J. L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M. N., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J. L., Wagermez, C., Walter, M., Zendjidjian, X., Abou Kassm, Sandra, Limosin, Frederic, Naja, Wadih, Vandel, Pierre, Sanchez-Rico, Marina, Alvarado, Jesus M., Gunten, Armin, Hoertel, Nicolas, Ades, J., Alezrah, C., Amado, I, Amar, G., Andrei, O., Arbault, D., Archambault, G., Aurifeuille, G., Barriere, S., Bera-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guerin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A. M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V, Chabannes, J. M., Charlot, V, Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J. P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., da Rin, D., Denis, J. B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, Fabien, Godart, F., Gourevitch, R., Delyle, Grassin A., Gremion, J., Gres, H., Griner, V, Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Haouzir, S., Hanon, C., Hazif-Thomas, C., Heron, A., Hubsch, B., Jalenques, I, Januel, D., Kaladjian, A., Karnycheff, J. F., Kebir, O., Krebs, M. O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V, Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Llorca, P. M., Loeffel, P., Louville, P., Navarro, Lucas S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I, Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Ades, Niro, Nubukpo, P., Omnes, C., Papin, S., Paris, P., Fondation FondaMental [Créteil], Weizenbaum Institut [Berlin], Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Agence nationale de la sécurité des systèmes d'information (ANSSI), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Research Center for Biosciences and Health Technologies [Lisboa] (CBIOS), Universidade Lusófona's, PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX (PHENIX), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Modélisation de la matière condensée et des interfaces (MMCI), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Kantar – Health Division, Partenaires INRAE, Institut National de la Santé et de la Recherche Médicale (INSERM), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de biologie et chimie des protéines [Lyon] (IBCP), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale (EA7479 SPURBO), Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Service de Psychiatrie, Hôpital de la Conception, Piici, UMR 7298, Aix-Marseille Université-CNRS, Marseille, France, Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Département de psychiatrie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), French Society for Biological Psychiatry and Neuropsychopharmacology, CHU Clermont-Ferrand, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Hôpital Foch [Suresnes], Università degli studi di Genova = University of Genoa (UniGe), Unité de recherche Mathématiques et Informatique Appliquées (MIA), Institut National de la Recherche Agronomique (INRA), Fédération Française de Triathlon (FFTRI), AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU ESPRIT, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, Inserm U1266, 178, rue des Renouillers, 92700 Colombes, France, UFR de Médecine Paris Nord, Université de Paris, 16, rue Henri Huchard, 75018 Paris, France., Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Laboratoire de Physique des Lasers (LPL), Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Groupement de recherche en Psychiatrie (GDR Psychiatrie (3557)), Centre National de la Recherche Scientifique (CNRS), Université Paris Cité (UPCité), Synchrotron SOLEIL (SSOLEIL), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Hôpital Paul Brousse, Digitéo, Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), RiverLy - Fonctionnement des hydrosystèmes (RiverLy), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sonatrach Exploration, and Centre Hospitalier Victor Jousselin de Dreux

Subjects
Psychosis, Pediatrics, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], Late onset, Schizoaffective disorder, Comorbidity, Odds ratio, medicine.disease, Psychiatry and Mental health, Cross-Sectional Studies, Psychotic Disorders, Quality of life, Schizophrenia, Quality of Life, medicine, Humans, Geriatrics and Gerontology, business, Aged, Diagnosis of schizophrenia
Abstract

International audience; Objectives Data are scarce regarding the potential clinical differences between non-late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late-onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very-late-onset schizophrenia-like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non-age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross-sectional multicentre study that recruited in- and outpatients older adults (aged >= 55 years) with an ICD-10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy-two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p < 0.05). However, the magnitude of these associations was modest, with significant adjusted odds ratios ranging from 0.71 to 1.24, and there were no significant between-group differences in other characteristics. Conclusion In an age-matched multicenter sample of elderly patients with schizophrenia, older adults with LOS were largely similar to older adults with NLOS in terms of clinical characteristics. The few differences observed may be at least partially related to symptom fluctuation with time. Implications of these findings for pharmacological and nonpharmacological management is yet to be determined.

Published
2021
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155. Interconnect-Free Multibit Arithmetic and Logic Unit in a Single Reconfigurable 3 μm2 Plasmonic Cavity

Author

Kumar, Upkar, primary, Cuche, Aurélien, additional, Girard, Christian, additional, Viarbitskaya, Sviatlana, additional, Dell’Ova, Florian, additional, Al Rafrafin, Raminfar, additional, Colas des Francs, Gérard, additional, Bolisetty, Sreenath, additional, Mezzenga, Raffaele, additional, Bouhelier, Alexandre, additional, and Dujardin, Erik, additional

Published
2021
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156. The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration. Insights from familial polyposis patients

Author

Mastrogiovanni, Marta, primary, Vargas, Pablo, additional, Rose, Thierry, additional, Cuche, Céline, additional, Juzans, Marie, additional, Esposito, Elric, additional, Laude, Hélène, additional, Renaudat, Charlotte, additional, Ungeheuer, Marie-Noëlle, additional, Delon, Jérôme, additional, Alcover, Andrés, additional, and Di Bartolo, Vincenzo, additional

Published
2021
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158. Unveiling the optical emission channels of monolayer semiconductors coupled to silicon nanoantennas

Author

Gonzague Agez, Frank Fournel, Kenji Watanabe, Vincent Larrey, Jean-Marie Poumirol, Vincent Paillard, Ioannis Paradisanos, Shivangi Shree, Aurélien Cuche, Takashi Taniguchi, Xavier Marie, Cedric Robert, Nicolas Mallet, Bernhard Urbaszek, Peter R. Wiecha, Guilhem Larrieu, Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Laboratoire de physique et chimie des nano-objets (LPCNO), Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC), Équipe Matériaux et Procédés pour la Nanoélectronique (LAAS-MPN), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Nano-Optique et Nanomatériaux pour l'optique (CEMES-NeO), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), ANR-17-EURE-0009,NanoX,Science et Ingénierie à l'Echelle Nano(2017), ANR-19-CE24-0020,SPINOXIDE,Injection et détection de spin dans des nanostructures tout oxyde(2019), Université Toulouse 1 Capitole (UT1)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Service Informatique : Développement, Exploitation et Assistance (LAAS-IDEA), Laboratory for Integrated Micro Mechatronics Systems (LIMMS), and The University of Tokyo-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Photoluminescence, excitons, Silicon, Exciton, dielectric nanoantennas, chemistry.chemical_element, FOS: Physical sciences, 02 engineering and technology, Dielectric, 01 natural sciences, Mie-tronics, [PHYS.PHYS.PHYS-COMP-PH]Physics [physics]/Physics [physics]/Computational Physics [physics.comp-ph], 010309 optics, strain, 0103 physical sciences, Monolayer, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Spontaneous emission, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Electrical and Electronic Engineering, [PHYS.COND.CM-MSQHE]Physics [physics]/Condensed Matter [cond-mat]/Mesoscopic Systems and Quantum Hall Effect [cond-mat.mes-hall], ComputingMilieux_MISCELLANEOUS, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Condensed Matter - Mesoscale and Nanoscale Physics, business.industry, transition metal dichalcogenides, 2D materials, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, [PHYS.PHYS.PHYS-GEN-PH]Physics [physics]/Physics [physics]/General Physics [physics.gen-ph], Electronic, Optical and Magnetic Materials, Semiconductor, chemistry, Optoelectronics, Light emission, 0210 nano-technology, business, Biotechnology
Abstract

Monolayers (MLs) of transition metal dichalcogenides (TMDs) such as WSe2 and MoSe2 can be placed by dry stamping directly on broadband dielectric resonators, which have the ability to enhance the spontaneous emission rate and brightness of solid-state emitters at room temperature. We show strongly enhanced emission and directivity modifications in room temperature photoluminescence mapping experiments. By varying TMD material (WSe2 versus MoSe2) transferred on silicon nanoresonators with various designs (planarized versus non-planarized), we experimentally separate the different physical mechanisms that govern the global light emission enhancement. For WSe2 and MoSe2 we address the effects of Mie Resonances and strain in the monolayer. For WSe2 an important additional contribution comes from out-of-plane exciton dipoles. This paves the way for more targeted designs of TMD-Si nanoresonator structures for room temperature applications., Comment: 10 pages, 5 figures

Published
2020
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159. Single plasmon spatial and spectral sorting on a crystalline two-dimensional plasmonic platform

Author

Erik Dujardin, Raffaele Mezzenga, Upkar Kumar, Sreenath Bolisetty, Christian Girard, Aurélien Cuche, Nano-Optique et Nanomatériaux pour l'optique (CEMES-NeO), Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Health Sciences and Technology [ETH Zürich] (D-HEST), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Groupe NanoSciences (CEMES-GNS), ANR-17-EURE-0009,NanoX,Science et Ingénierie à l'Echelle Nano(2017), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
Mesoscopic physics, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Microscope, Materials science, Field (physics), business.industry, Physics::Optics, Near and far field, Context (language use), 02 engineering and technology, 021001 nanoscience & nanotechnology, Distributed Bragg reflector, 01 natural sciences, [PHYS.PHYS.PHYS-GEN-PH]Physics [physics]/Physics [physics]/General Physics [physics.gen-ph], law.invention, law, 0103 physical sciences, Physics::Atomic and Molecular Clusters, Optoelectronics, General Materials Science, 010306 general physics, 0210 nano-technology, business, Nanodiamond, Plasmon
Abstract

International audience; In the context of the emerging field of quantum plasmonics, we demonstrate in this manuscript the wavelength-dependent propagation and sorting of single plasmons launched in a two-dimensional crystalline gold flake by a broadband quantum nanoemitter. The stream of single plasmons in the visible is produced by a nanodiamond hosting a single nitrogen-vacancy color center positioned in the near field of the mesoscopic metallic microplatelet. Spatially and spectrally resolved images of the single plasmon propagation in the pristine hexagonal flake, and then in the same structure after insertion of a Bragg mirror, are obtained by filtered image-plane acquisitions on a leakage-radiation microscope. Our work on two-dimensional crystalline structures paves the way to future fundamental studies and applications in quantum plasmonics.

Published
2020
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160. Polarizabilities of complex individual dielectric or plasmonic nanostructures

Author

Peter R. Wiecha, Aurélien Cuche, Christian Girard, Arnaud Arbouet, Otto L. Muskens, Clément Majorel, Adelin Patoux, Nano-Optique et Nanomatériaux pour l'optique (CEMES-NeO), Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Materials science, Condensed Matter - Mesoscale and Nanoscale Physics, business.industry, Phase (waves), FOS: Physical sciences, Physics::Optics, 02 engineering and technology, Dielectric, 021001 nanoscience & nanotechnology, 01 natural sciences, Molecular physics, [PHYS.PHYS.PHYS-GEN-PH]Physics [physics]/Physics [physics]/General Physics [physics.gen-ph], Dipole, Polarizability, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 0103 physical sciences, SPHERES, Photonics, 010306 general physics, 0210 nano-technology, business, Magnetic dipole, Plasmon
Abstract

When the sizes of photonic nanoparticles are much smaller than the excitation wavelength, their optical response can be efficiently described with a series of polarizability tensors. Here, we propose a universal method to extract the different components of the response tensors associated with small plasmonic or dielectric particles. We demonstrate that the optical response can be faithfully approximated, as long as the effective dipole is not induced by retardation effects, hence do not depend on the phase of the illumination. We show that the conventional approximation breaks down for a phase-driven dipolar response, such as optical magnetic resonances in dielectric nanostructures. To describe such retardation induced dipole resonances in intermediate-size dielectric nanostructures, we introduce "pseudo-polarizabilities" including first-order phase effects, which we demonstrate at the example of magnetic dipole resonances in dielectric spheres and ellipsoids. Our method paves the way for fast simulations of large and inhomogeneous meta-surfaces., Comment: 13 pages, 11 figures

Published
2020
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161. Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions

Author

Marie Juzans, Pascal Bochet, Marta Mastrogiovanni, Vincenzo Di Bartolo, Thierry Rose, Céline Cuche, Andrés Alcover, Di Bartolo, Vincenzo, Développment d'une infrastructure française distribuée coordonnée - - France-BioImaging2010 - ANR-10-INBS-0004 - INBS - VALID, Institut Pasteur International Docotal Program - PASTEURDOC - - H20202015-10-01 - 2020-10-01 - 665807 - VALID, Biologie Cellulaire des Lymphocytes - Lymphocyte Cell Biology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe labellisée Ligue contre le Cancer, Collège Doctoral, Sorbonne Université (SU), Analyse d'images biologiques - Biological Image Analysis (BIA), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from La Ligue Nationale contre le Cancer, Equipe Labellisée 2018, and institutional grants from the Institut Pasteur and INSERM. M.J. was supported by a Ligue Nationale contre le Cancer Doctoral Fellowship and the Institut Pasteur. M.M. is a scholar of the Pasteur Paris University International Doctoral Program, supported by the Institut Pasteur and the European Union Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement 665807 (COFUND-PASTEURDOC). The Unit of Technology and Service Photonic BioImaging core facility is supported by the French National Research Agency France BioImaging (ANR-10–INSB–04, Investments for the Future)., We thank Drs. F. Sepulveda and D. Scott-Algara for scientific advice, J.Y. Tinevez, A. Salles, J. Fernandes and the Unit of Technology and Service Photonic BioImaging facility, Institut Pasteur for technical support and the ICAReB Biological Resources core facility team, Institut Pasteur for providing primary T cell samples. We are grateful to I. Näthke for Abs., ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), European Project: 665807,H2020,H2020-MSCA-COFUND-2014,PASTEURDOC(2015), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Collège doctoral [Sorbonne universités], and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Immunological Synapses, Adenomatous polyposis coli, Immunology, Adenomatous Polyposis Coli Protein, Mice, Transgenic, Biology, Microtubules, T-Lymphocytes, Regulatory, Immunological synapse, Familial adenomatous polyposis, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Line, Tumor, Cell polarity, medicine, Immunology and Allergy, Cytotoxic T cell, Animals, Humans, Transcription factor, Cytoskeleton, 030304 developmental biology, Epithelial cell differentiation, 0303 health sciences, NFATC Transcription Factors, NFAT, Cell Differentiation, General Medicine, medicine.disease, Actins, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Adenomatous Polyposis Coli, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, Mutation, biology.protein, Female, 030215 immunology, Signal Transduction
Abstract

Adenomatous polyposis coli (Apc) is a cell polarity regulator and a tumor suppressor associated with familial adenomatous polyposis and colorectal cancer. Apc involvement in T lymphocyte functions and antitumor immunity remains poorly understood. Investigating Apc-depleted human CD8 T cells and CD8 T cells from ApcMin/+ mutant mice, we found that Apc regulates actin and microtubule cytoskeleton remodeling at the immunological synapse, controlling synapse morphology and stability and lytic granule dynamics, including targeting and fusion at the synapse. Ultimately, Apc tunes cytotoxic T cell activity, leading to tumor cell killing. Furthermore, Apc modulates early TCR signaling and nuclear translocation of the NFAT transcription factor with mild consequences on the expression of some differentiation markers. In contrast, no differences in the production of effector cytokines were observed. These results, together with our previous findings on Apc function in regulatory T cells, indicate that Apc mutations may cause a dual damage, first unbalancing epithelial cell differentiation and growth driving epithelial neoplasms and, second, impairing T cell–mediated antitumor immunity at several levels.

Published
2020
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162. Magnetic and electric Purcell factor control through geometry optimization of high index dielectric nanostructures

Author

Yoann Brûlé, Peter Wiecha, Aurélien Cuche, Vincent Paillard, Gérard Colas des Francs, Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Équipe Matériaux et Procédés pour la Nanoélectronique (LAAS-MPN), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Nano-Optique et Nanomatériaux pour l'optique (CEMES-NeO), Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), ANR-21-ESRE-0040,SMARTLIGHT,SMARTLIGHT(2021), and ANR-19-CE24-0026,HiLight,Nanostructures diélectriques à haut indice pour le contrôle de l'émission et de la propagation de la lumière(2019)

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], FOS: Physical sciences, Computational Physics (physics.comp-ph), Physics - Computational Physics, [PHYS.PHYS.PHYS-GEN-PH]Physics [physics]/Physics [physics]/General Physics [physics.gen-ph], Atomic and Molecular Physics, and Optics, Physics - Optics, Optics (physics.optics)
Abstract

We design planar silicon antennas for controlling the emission rate of magnetic or electric dipolar emitters. Evolutionary algorithms coupled to the Green Dyadic Method lead to different optimized geometries which depend on the nature and orientation of the dipoles. We discuss the physical origin of the obtained configurations thanks to modal analysis but also emphasize the role of nanoscale design of the LDOS. We complete our study using finite element method and demonstrate an enhancement up to 2000 of the magnetic Purcell factor in europium ions. Our work brings together random optimizations to explore geometric parameters without constraint, a first order deterministic approach to understand the optimized designs and a modal analysis which clarifies the physical origin of the exaltation of the magnetic Purcell effect., Comment: 18 pages, 11 figures, research article

Published
2022
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163. Submicrometer optical tomography by multiple-wavelength digital holographic microscopy

Author

Montfort, Frederic, Colomb, Tristan, Charriere, Florian, Kuhn, Jonas, Marquet, Pierre, Cuche, Etienne, Herminjard, Sylvain, and Depeursinge, Christian

Subjects
Microscope and microscopy -- Usage, Optical tomography -- Methods, Numerical analysis, Astronomy, Physics
Abstract

We present a method for submicrometer tomographic imaging using multiple wavelengths in digital holographic microscopy. This method is based on the recording, at different wavelengths equally separated in the k domain, in off-axis geometry, of the interference between a reference wave and an object wave reflected by a microscopic specimen and magnified by a microscope objective. A CCD camera records the holograms consecutively, which are then numerically reconstructed following the convolution formulation to obtain each corresponding complex object wavefront. Their relative phases are adjusted to be equal in a given plane of interest and the resulting complex wavefronts are summed. The result of this operation is a constructive addition of complex waves in the selected plane and destructive addition in the others. Tomography is thus obtained by the attenuation of the amplitude out of the plane of interest. Numerical variation of the plane of interest enables one to scan the object in depth. For the presented simulations and experiments, 20 wavelengths are used in the 480-700 nm range. The result is a sectioning of the object in slices 725 nm thick. OCIS codes: 090.1760, 100.3010, 110.0180, 110.6960, 110.6880.

Published
2006

164. Shot-noise influence on the reconstructed phase image signal-to-noise ratio in digital holographic microscopy

Author

Charriere, Florian, Colomb, Tristan, Montfort, Frederic, Cuche, Etienne, Marquet, Pierre, and Depeursinge, Christian

Subjects
Holography -- Analysis, Microscope and microscopy, Astronomy, Physics
Abstract

In digital holographic microscopy, shot noise is an intrinsic part of the recording process with the digital camera. We present a study based on simulations and real measurements describing the shot-noise influence in the quality of the reconstructed phase images. Different configurations of the reference wave and the object wave intensities will be discussed, illustrating the detection limit and the coherent amplification of the object wave. The signal-to-noise ratio (SNR) calculation of the reconstructed phase images based on the decision statistical theory is derived from a model for image quality estimation proposed by Wagner and Brown [Phys. Med. Biol. 30, 489 (1985)]. It will be shown that a phase image with a SNR above 10 can be obtained with a mean intensity lower than 10 photons per pixel and per hologram coming from the observed object. Experimental measurements on a glass-chrome probe will be presented to illustrate the main results of the simulations. OCIS codes: 090.0090, 030.4280, 030.5290, 110.3000.

Published
2006

165. Automatic procedure for aberration compensation in digital holographic microscopy and applications to specimen shape compensation

Author

Colomb, Tristan, Cuche, Etienne, Charriere, Florian, Kuhn, Jonas, Aspert, Nicolas, Montfort, Frederic, Marquet, Pierre, and Depeursinge, Christian

Subjects
Aberration -- Usage, Metals -- Surfaces, Metals -- Structure, Metals -- Research, Astronomy, Physics
Abstract

We present a procedure that compensates for phase aberrations in digital holographic microscopy by computing a polynomial phase mask directly from the hologram. The phase-mask parameters are computed automatically without knowledge of physical values such as wave vectors, focal lengths, or distances. This method enables one to reconstruct correct and accurate phase distributions, even in the presence of strong and high-order aberrations. Examples of applications are shown for microlens imaging and for compensating for the deformations associated with a tilted thick plate. Finally we show that this method allows compensation for the curvature of the specimen, revealing its surface defects and roughness. Examples of applications are shown for microlenses and metallic sphere imaging. OCIS codes: 090.1760, 090.1000, 180.0180, 120.5050, 120.3620.

Published
2006

166. Characterization of microlenses by digital holographic microscopy

Author

Charriere, Florian, Kuhn, Jonas, Colomb, Tristan, Montfort, Frederic, Cuche, Etienne, Emery, Yves, Weible, Kenneth, Marquet, Pierre, and Depeursinge, Christian

Subjects
Holographic testing -- Analysis, Interferometers -- Usage, Lenses -- Usage, Astronomy, Physics
Abstract

We demonstrate the use of digital holographic microscopy (DHM) as a metrological tool in micro-optics testing. Measurement principles are compared with those performed with Twyman-Green, Mach-Zehnder, and white-light interferometers. Measurements performed on refractive microlenses with reflection DHM are compared with measurements performed with standard interferometers. Key features of DHM such as digital focusing, measurement of shape differences with respect to a perfect model, surface roughness measurements, and optical performance evaluation are discussed. The capability of imaging nonspherical lenses without any modification of the optomechanical setup is a key advantage of DHM compared with conventional measurement tools and is demonstrated on a cylindrical microlens and a square lens array. OCIS codes: 090.0090, 090.1760, 120.3620.

Published
2006

167. L’accompagnement, source de création de savoirs

Author

Catherine Canivet, Catherine Cuche, and Jean Donnay

Subjects
educational research, knowledge and didactics, educational cooperation and collaboration, Education
Abstract

Cet article tente de rencontrer un double enjeu. Même s’ils ne fonctionnent pas de la même manière, il s’agit de réaliser une lecture transversale de plusieurs types d’accompagnement d’élèves et d’étudiants en difficulté - qu’ils soient ou non à haut(s) potentiel(s) - de praticiens de l’enseignement - novices ou d’expérience - de conseillers pédagogiques et même d’accompagnement individuel ou en groupes d’équipes éducatives ainsi que d’établissements scolaires dans leur ensemble. Par ailleurs, nous proposons que le travail d’accompagnateur, voire de compagnonnage réflexif, confine à celui de chercheur et peut créer (co-créer) des savoirs de natures différentes dont certains peuvent être reconnus par une certaine communauté scientifique. Pour la clarté du texte, nous avons considéré plus spécialement l’accompagnement de praticien de l’enseignement, en nous concentrant sur les savoirs de l’accompagnateur-chercheur.

Published
2010
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169. Polarization microscopy by use of digital holography: application to optical-fiber birefringence measurements

Author

Colomb, Tristan, Durr, Florian, Cuche, Etienne, Marquet, Pierre, Limberger, Hans G., Salathe, Rene-Paul, and Depeursinge, Christian

Subjects
Photography -- Comparative analysis, Fiber optics -- Equipment and supplies, Fiber optics -- Comparative analysis, Astronomy, Physics
Abstract

We present a digital holographic microscope that permits one to image polarization state. This technique results from the coupling of digital holographic microscopy and polarization digital holography. The interference between two orthogonally polarized reference waves and the wave transmitted by a microscopic sample, magnified by a microscope objective, is recorded on a CCD camera. The off-axis geometry permits one to reconstruct separately from this single hologram two wavefronts that are used to image the object-wave Jones vector. We applied this technique to image the birefringence of a bent fiber. To evaluate the precision of the phase-difference measurement, the birefringence induced by internal stress in an optical fiber is measured and compared to the birefringence profile captured by a standard method, which had been developed to obtain high-resolution birefringence profiles of optical fibers.

Published
2005

170. Time-domain optical coherence tomography with digital holographic microscopy

Author

Massatsch, Pia, Charriere, Florian, Cuche, Etienne, Marquet, Pierre, and Depeursinge, Christian D.

Subjects
Optics -- Research, Ophthalmology -- Research, Optical tomography -- Research, Astronomy, Physics
Abstract

We show that digital holography can be combined easily with optical coherence tomography approach. Varying the reference path length is the means used to acquire a series of holograms at different depths, providing after reconstruction images of slices at different depths in the specimen thanks to the short-coherence length of light source. A metallic object, covered by a 150-[micro]m-thick onion cell, is imaged with high resolution. Applications in ophthalmology are shown: structures of the anterior eye, the cornea, and the iris, are studied on enucleated porcine eyes. Tomographic images of the iris border close to the pupil were obtained 165 [micro]m underneath the eye surface. OCIS codes: 090.0090, 090.1760, 110.4500, 170.7050.

Published
2005

178. Polarization imaging by use of digital holography

Author

Colomb, Tristan, Dahlgren, Pia, Beghuin, Didier, Cuche, Etienne, Marquet, Pierre, and Depeursinge, Christian

Subjects
Digital electronic instruments -- Research, Holography -- Methods, Imaging systems -- Evaluation, Electromagnetic waves -- Polarization, Astronomy, Physics
Abstract

We present what we believe to be a new digital holographic imaging method that is able to determine simultaneously the distributions of intensity, phase, and polarization state at the surface of a specimen on the basis of a single image acquisition. Two reference waves with orthogonal polarization states interfere with the object wave to create a hologram that is recorded on a CCD camera. Two wave fronts, one for each perpendicular polarization state, are numerically reconstructed in intensity and phase. Combining the intensity and the phase distributions of these two wave fronts permits the determination of all the components of the Jones vector of the object-wave front. We show that this method can be used to image and measure the distribution of the polarization state at the surface of a specimen, and the obtained results indicate that precise quantitative measurements of the polarization state can be achieved. An application of the method to image the birefringence of a stressed polymethyl methacrylate sample is presented. OCIS codes: 090.0090, 090.1760, 120.0120, 120.5410, 070.2580, 260.1440, 260.5430, 040.1520

Published
2002

180. Valeur pronostique de la lymphopénie T CD4 + dans le cancer du poumon non à petites cellules

Author

Eberst, G., primary, Vernerey, D., additional, Laheurte, C., additional, Kaulek, V., additional, Meurisse, A., additional, Cuche, L., additional, Jacoulet, P., additional, Lahourcade, J., additional, Almotlak, H., additional, Orillard, E., additional, Guion-Dusserre, M., additional, Gainet-Brun, M., additional, Fabre, E., additional, Le Pimpec-Barthes, F., additional, Adotevi, O., additional, and Westeel, V., additional

Published
2021
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181. Unveiling the Optical Emission Channels of Monolayer Semiconductors Coupled to Silicon Nanoantennas

Author

Poumirol, Jean-Marie, primary, Paradisanos, Ioannis, additional, Shree, Shivangi, additional, Agez, Gonzague, additional, Marie, Xavier, additional, Robert, Cédric, additional, Mallet, Nicolas, additional, Wiecha, Peter R., additional, Larrieu, Guilhem, additional, Larrey, Vincent, additional, Fournel, Frank, additional, Watanabe, Kenji, additional, Taniguchi, Takashi, additional, Cuche, Aurélien, additional, Paillard, Vincent, additional, and Urbaszek, Bernhard, additional

Published
2020
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184. (Invited) High Index Dielectric Nanoantennas for Light Management, Controlled Photoluminescence of Quantum Emitters, and Semiconductor-Based Plasmonics

Author

Paillard, Vincent, primary, Majorel, Clement, additional, Arbouet, Arnaud, additional, Bonafos, Caroline, additional, Chery, Nicolas, additional, Cuche, Aurélien, additional, Girard, Christian, additional, Gourbilleau, Fabrice, additional, Poumirol, Jean-Marie, additional, Wiecha, Peter R., additional, Boisron, Olivier, additional, Masenelli, Bruno, additional, Mallet, Nicolas, additional, Monflier, Richard, additional, Cristiano, Fuccio, additional, Larrieu, Guilhem, additional, Rinnert, Hervé, additional, Acosta-Alba, Pablo, additional, Larrey, Vincent, additional, Fournel, Frank, additional, Royet, Anne-Sophie, additional, and Kerdilès, Sébastien, additional

Published
2020
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189. HAMAP as SPARQL rules—A portable annotation pipeline for genomes and proteomes

Author

Edouard de Castro, Chantal Hulo, Delphine Baratin, Béatrice A. Cuche, Sebastien Gehant, Elisabeth Coudert, Catherine Rivoire, Ivo Pedruzzi, Nicole Redaschi, Alan Bridge, Patrick Masson, Ioannis Xenarios, Jerven Bolleman, and Andrea H. Auchincloss

Subjects
File Transfer Protocol, Computer science, Health Informatics, SPARQL, 03 medical and health sciences, Annotation, Sequence Analysis, Protein, Animals, Humans, RDF, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 030304 developmental biology, computer.programming_language, function, 0303 health sciences, Information retrieval, Syntax (programming languages), Research, 030302 biochemistry & molecular biology, InformationSystems_DATABASEMANAGEMENT, Molecular Sequence Annotation, prediction, Genomics, Sequence Analysis, DNA, computer.file_format, Pipeline (software), Computer Science Applications, UniProt, protein, computer, Software, RDF query language
Abstract

BackgroundGenome and proteome annotation pipelines are generally custom built and not easily reusable by other groups. This leads to duplication of effort, increased costs, and suboptimal annotation quality. One way to address these issues is to encourage the adoption of annotation standards and technological solutions that enable the sharing of biological knowledge and tools for genome and proteome annotation.ResultsHere we demonstrate one approach to generate portable genome and proteome annotation pipelines that users can run without recourse to custom software. This proof of concept uses our own rule-based annotation pipeline HAMAP, which provides functional annotation for protein sequences to the same depth and quality as UniProtKB/Swiss-Prot, and the World Wide Web Consortium (W3C) standards Resource Description Framework (RDF) and SPARQL (a recursive acronym for the SPARQL Protocol and RDF Query Language). We translate complex HAMAP rules into the W3C standard SPARQL 1.1 syntax, and then apply them to protein sequences in RDF format using freely available SPARQL engines. This approach supports the generation of annotation that is identical to that generated by our own in-house pipeline, using standard, off-the-shelf solutions, and is applicable to any genome or proteome annotation pipeline.ConclusionsHAMAP SPARQL rules are freely available for download from the HAMAP FTP site, ftp://ftp.expasy.org/databases/hamap/sparql/, under the CC-BY-ND 4.0 license. The annotations generated by the rules are under the CC-BY 4.0 license. A tutorial and supplementary code to use HAMAP as SPARQL are available on GitHub at https://github.com/sib-swiss/HAMAP-SPARQL, and general documentation about HAMAP can be found on the HAMAP website at https://hamap.expasy.org.

Published
2020
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190. Calreticulin Expression Analysis in Small Saphenous Vein

Author

Sanzana-Cuche, R, Fernández, E, Leiva, A. P, and Rosas, C. C

Subjects
genetic structures, Vena safena parva, cardiovascular system, cardiovascular diseases, Matriz extracelular, Extracellular matrix, Small saphenous vein, Calreticulin, Calreticulina
Abstract

RESUMEN: La proteína chaperona Calreticulina (CRT), ha sido identificada en retículo endoplásmico (RE) y últimamente en la matriz extracelular (MEC) de predentina y arterias, atribuyéndole diferentes funciones extracelulares entre las que destacan la adhesión celular, regulación de la MEC y prevención en la formación de trombos. El objetivo del estudio fue identificar la presencia de CRT en MEC de vena safena parva. Se extrajo una muestra de vena safena parva de un espécimen masculino y luego fue procesada por medios histológicos e inmunohistoquímicos para identificar su presencia. Mediante técnicas de inmunohistoquímica se pudo evidenciar la presencia de CRT en la MEC de la adventicia de vena safena parva. La presencia de CRT en MEC de safena parva orienta a que CRT tienen funciones de tipo extracelular en esta localización, pero es necesario realizar estudios más precisos para dilucidar sus principales funciones en la zona. SUMMARY: Calreticulin (CRT) protein, has been identified in the endoplasmic reticulum (ER) and lately in the extracellular matrix (ECM) of predentine and arteries. It is responsible for different extracellular functions, such as cell adhesion, ECM regulation, and the prevention of thrombosis. The aim was to identify the presence of CRT in ECM of small saphenous vein. A sample of small saphenous vein from a male specimen was extracted and then processed by histological and immunohistochemical assays to identify its presence. The presence of CRT in the ECM of the small saphenous vein was observed by immunohistochemical techniques. The presence of CRT in the small saphenous vein ECM, indicates that CRT have extracellular functions in this area, however, more precise studies are necessary to determine its main functions.

Published
2020

192. ESO897466 Supplemental Figure - Supplemental material for Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group

Author

Cadilhac, Dominique A, Joosup Kim, Wilson, Alastair, Berge, Eivind, Patel, Anita, Myzoon Ali, Saver, Jeffrey, Christensen, Hanne, Cuche, Matthieu, Crews, Sean, Wu, Olivia, Provoyeur, Marine, McMeekin, Peter, Durand-Zaleski, Isabelle, Ford, Gary A, Muhlemann, Natalia, Bath, Philip M, Azmil H Abdul-Rahim, Sunnerhagen, Katharina, Meretoja, Atte, Thijs, Vincent, Weimar, Christian, Ayrton Massaro, Annemarei Ranta, and Lees, Kennedy R

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, ESO897466 Supplemental Figure for Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group by Dominique A Cadilhac, Joosup Kim, Alastair Wilson, Eivind Berge, Anita Patel, Myzoon Ali, Jeffrey Saver, Hanne Christensen, Matthieu Cuche, Sean Crews, Olivia Wu, Marine Provoyeur, Peter McMeekin, Isabelle Durand-Zaleski, Gary A Ford, Natalia Muhlemann, Philip M Bath, Azmil H Abdul-Rahim, Katharina Sunnerhagen, Atte Meretoja, Vincent Thijs, Christian Weimar, Ayrton Massaro, Annemarei Ranta and Kennedy R Lees; on behalf of the ESO Health Economics Working group in European Stroke Journal

Published
2020
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194. UniProt: the universal protein knowledgebase in 2021

Author

Fábio Madeira, Emmanuel Boutet, Ursula Hinz, Teresa Batista Neto, Parit Bansal, Manuela Pruess, Kristian B. Axelsen, Arnaud Kerhornou, Cecilia N. Arighi, Lai-Su L. Yeh, Shadab Ahmad, John S. Garavelli, Cathy H. Wu, Florence Jungo, Alan Bridge, Leonardo Gonzales, Sandra Orchard, Patrick Masson, Douglas Teodoro, Maria Jesus Martin, Anne Estreicher, Kamal Chikh Echioukh, Hongzhan Huang, Patrick Ruch, Christian J. A. Sigrist, C. R. Vinayaka, Yvonne Lussi, Anne Morgat, Yongxing Chen, Austra Cukura, Emanuele Alpi, Ramona Britto, Alexandr Ignatchenko, Sylvain Poux, Rizwan Ishtiaq, Lionel Breuza, Jun Fan, Edouard de Castro, Petteri Jokinen, Nicole Redaschi, Darren A. Natale, Daniel Rice, Giuseppe Insana, George Georghiou, Nevila Hyka-Nouspikel, Karen E. Ross, Katie Moulang, Vicente Lara, Arnaud Gos, Michael Tognolli, Alok Mishra, Ivo Pedruzzi, Nidhi Tyagi, Leyla Jael Garcia Castro, Edward Turner, Cristina Casals-Casas, Tunca Doğan, Nadine Gruaz-Gumowski, Chantal Hulo, Maria Livia Famiglietti, Andrew Nightingale, Paul Denny, Lucila Aimo, Rossana Zaru, Vishal Joshi, Alistair MacDougall, Andre Stutz, Penelope Garmiri, Carla Susana Oliveira, Hermann Zellner, Marie-Claude Blatter, Emily H Bowler-Barnett, Philippe Le Mercier, Abdulrahman Hussein, Catherine Rivoire, Tony Sawford, Milagros Rodriguez Lopez, Salvo Paesano, Vladimir Volynkin, Manuela Menchi, Hema Bye-A-Jee, Monica Pozzato, Kati Laiho, Delphine Baratin, Qinghua Wang, Leslie Arminski, Preethi Vasudev, Sangya Pundir, Jian Zhang, Emma Hatton-Ellis, Kate Warner, Lucille Pourcel, Elisabeth Gasteiger, Marc Feuermann, Thierry Lombardot, Jerven Bolleman, Mahdi Mahmoudy, Shyamala Sundaram, Alex Bateman, Xavier Watkins, Rahat Agivetova, Guoying Qi, Peter B. McGarvey, Xavier D. Martin, Chuming Chen, Jie Luo, Ray Coetzee, K Sonesson, Alan Wilter Sousa da Silva, ThankGod Ebenezer, Elena Speretta, Rodrigo Lopez, Elisabeth Coudert, Aurelien Luciani, Vivienne Baillie Gerritsen, Yuqi Wang, M Doche, Michele Magrane, Antonia Lock, Dolnide Dornevil, Sandrine Pilbout, Borisas Bursteinas, Andrea H. Auchincloss, Béatrice A. Cuche, Dushyanth Jyothi, Rabie Saidi, Joseph Sampson, Laure Verbregue, Sebastien Gehant, Guillaume Keller, Shriya Raj, Damien Lieberherr, Ghislaine Argoud-Puy, and Teodoro, Douglas

Subjects
Proteomics, COVID-19 / virology, Computational Biology / methods, Molecular Sequence Annotation / methods, Proteome, AcademicSubjects/SCI00010, Knowledge Bases, Computational biology, Proteomics / methods, Biology, ddc:616.0757, SARS-CoV-2 / physiology, COVID-19 / epidemiology, User-Computer Interface, Viral Proteins, 03 medical and health sciences, 0302 clinical medicine, SARS-CoV-2 / genetics, Data Curation / methods, Genetics, Redundancy (engineering), Viral Proteins / genetics, Humans, Database Issue, SARS-CoV-2 / metabolism, Databases, Protein, Pandemics, Data Curation, Proteome / metabolism, 030304 developmental biology, Proteome / genetics, Internet, 0303 health sciences, SARS-CoV-2, COVID-19 / prevention & control, COVID-19, Computational Biology, Molecular Sequence Annotation, Viral Proteins / metabolism, UniProt Knowledgebase, UniProt, 030217 neurology & neurosurgery
Abstract

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.

Published
2020

197. The 20 years of PROSITE

Author

Hulo, Nicolas, Bairoch, Amos, Bulliard, Virginie, Cerutti, Lorenzo, Cuche, Béatrice A., de Castro, Edouard, Lachaize, Corinne, Langendijk-Genevaux, Petra S., and Sigrist, Christian J. A.

Published
2008

198. All 2-Input Logic Gates and a Half-Adder in a Single Reconfigurable Plasmonic Cavity

Author

Kumar, Upkar, Cuche, Aurelien, Girard, Christian, Viarbitskaya, Sviatlana, Colas Des Francs, Gérard, Bolisetty, Sreenath, Mezzenga, Raffaele, Bouhelier, Alexandre, Dujardin, Erik, Groupe NanoSciences (CEMES-GNS), Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS), Department of Health Sciences and Technology [ETH Zürich] (D-HEST), and Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics]
Published
2019

199. Chez les patients porteurs de colostomie, quel est l'impact des différentes stratégies d'éducation thérapeutique sur les complications ?

Author

Cuche, Guillaume, Prêtre, Adrien, Roulet, Nicolas, and Voirol, Christian

Abstract

La colostomie fait partie de la famille des stomies. La stomie est l’ouverture chirurgicale d’un orifice sur la peau au niveau de l’abdomen. Cette stomie peut être provisoire ou définitive. Cette intervention est due entre autres à un cancer, une maladie inflammatoire, maladie diverticulaire, neurologique, traumatique, etc. La stomie peut induire de multiples complications qui influencent directement l’autonomie de la personne et sa qualité de vie. Les infirmiers ont un rôle à jouer dans la prise en charge des patients de développer leurs compétences sur la gestion de leur stomie (empowerment) et ainsi de les accompagner dans un processus favorisant l’autonomie. L’éducation thérapeutique est un outil adéquat et adaptable afin d’aider le patient à acquérir de nouvelles compétences et faciliter le changement de comportement en plus du changement physique. De plus, la maladie chronique est souvent la cause de réhospitalisation, ce qui influence les coûts de la santé. Diverses interventions semblent être des solutions efficaces pour assurer un suivi en partenariat avec le patient afin d’atteindre les objectifs d’autonomisation et d’acceptation nécessaires au processus d’empowerment.

Published
2019

200. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

A. Brochard, F. Slama, B. Beaufils, O. Guillin, P. Reynaud, M Masson, E. Duprat, M. Miron, Christine Passerieux, A. Rollet, Isabelle Amado, R. Tourtauchaux, H. Hadaoui, A. Leydier, Vincent Camus, Pierre Lavaud, C.E. Rengade, V. Vanhoucke, Nicolas Hoertel, S. Lucas Navarro, Thomas Charpeaud, C. Rodrigues, L. Yon, J. Adès, E. Venet, M.N. Vacheron, V. Griner, Ghassen Saba, T. Bichet, M. Bareil-Guérin, F. Limosin, C. Hanon, Olivier Blanc, H. Gres, L. Mekaoui, J. Mauvieux, Emmanuel Haffen, A. Radtchenko, Frédéric Limosin, D. Arbault, C. Fernandez, B. Rousselot, I. Maurs-Ferrer, A. Mihoubi, A. Heron, E. Tran, R. Gourevitch, O. Maillet, P. Legrand, S. Rubingher, J. Gremion, Xavier Zendjidjian, F. Getten, A.S. Seigneurie, P. Fonfrede, C. Clad-Mor, N. Freitas, A.M. Bouysse, Dominique Januel, Marion Leboyer, P. Vandel, L. Reinheimer, F. Petitjean, A. Rauzy, V. Niro Adès, V. Lemaire, Fabien Gierski, D. Levy-Chavagnat, C. Guggiari, J.F. Karnycheff, M. Cabot, C. Omnes, M. Mahi, A. Grassin Delyle, Hélène Verdoux, D. Robin, Cédric Lemogne, E. Diers, P. Gasnier, J.L. Vurpas, D. Da Rin, Christine Cuervo-Lombard, F. Blanadet, C. Hazif-Thomas, D. Duthoit, Céline Béra-Potelle, J.M. Chabannes, B. Segalas, Hugo Peyre, Hélène Denizot, J.B. Denis, A. Viala, Didier Boussiron, A. Semmak, P. Martin, C. Lajugie, Sarah Barrière, G. Mora, C. Barrouillet, M. Meniai, Michel Walter, J. Ben Ayed, J.P. Salvarelli, K. Benyacoub, T. Seguret, D. Thefenne, M. Benoit, Isabelle Jalenques, B. Bucheron, S. Papin, B. Cordier, D. Pringuey, E. Baup, M. Renard, A. Deperthuis, S. Haouzir, Pierre-Michel Llorca, Y. Blumenstock, A. Dammak, Bérengère Hübsch, D. Donneau, D. Sechter, E. Mechin, Jean-Pierre Schuster, Yvonne Blumenstock, N. Mages, J.C. Samuelian, J.L. Terra, Carlos Blanco, C. Wagermez, H. Bardou, Christophe Guerin-Langlois, A. Petit, A. Kaladjian, J. Gauillard, M. Taleb, M. Creixell, C. Scemama-Ammar, P. Nubukpo, S. Mazmanian, M. Lejoyeux, J. Perlbarg, F. Schürhoff, O. Kebir, G. Amar, O. Brochart, Christophe Portefaix, Christine-Vanessa Cuervo-Lombard, F. Costi, Rachel Pascal de Raykeer, H. Rahiou, C. Alezrah, J.P. Courcelles, N. Bazin, Delphine Raucher-Chéné, J. Pellerin, H. Cuche, V. Charlot, P. Paris, E. Leroy, M. Comisu, M. René, C. Martelli, Arthur Kaladjian, G. Vidon, C. Combes, O. Andréi, A. Manetti, A. Metton, J. Blanc-Comiti, Caroline Dubertret, S. Taisne, S. Perron, M.O. Krebs, M. Vitre, G. Archambault, P. Barrau, S. Dirami, F. Rondepierre, F. Godart, P. Dreano, N. Hoertel, G. Aurifeuille, P. Loeffel, P. Louville, C. Liling, Université Paris Descartes - Paris 5 (UPD5), Centre d’Etudes et de Recherches en Psychopathologie et Psychologie de la Santé (CERPPS), Université Toulouse - Jean Jaurès (UT2J), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Interactions cellulaires et moléculaires (ICM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Service psychiatrique de l'enfant et de l'adolescent [CHU Hôpital Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), French Society for Biological Psychiatry and Neuropsychopharmacology, Partenaires INRAE, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Dipartimento di Scienze della Terra, Universita degli studi di Genova, Unité de recherche Biométrie (UB), Institut National de la Recherche Agronomique (INRA), Fondation FondaMental [Créteil], Fédération Française de Triathlon (FFTRI), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centres d'addictologies - Région Centre, CHU Clermont-Ferrand, Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Service de Psychiatrie pour Adultes [CHU Reims], Centre Hospitalier Universitaire de Reims (CHU Reims), Université Montpellier 1 (UM1), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-CHU Clermont-Ferrand, Sonatrach Exploration, Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Agriculture et forêt méditerranéenne (UR AFAX), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Kantar – Health Division, Institut National de Recherche en Génie Rural Eaux et Forêts (INRGREF), Ecole Nationale du Génie Rural, des Eaux et des Forêts (ENGREF)-Institution de la Recherche et de l'Enseignement Supérieur Agricoles [Tunis] (IRESA), Département de psychiatrie [CHU de Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Pôle Universitaire de Psychiatrie Adulte, Différenciation et communication neuronale et neuroendocrine (DC2N), and PHRC 2008-N11-01, Ministère des Affaires Sociales et de la Santé

Subjects
Male, Quality of life, Schizoaffective disorder, [SDV]Life Sciences [q-bio], [SHS.PSY]Humanities and Social Sciences/Psychology, Structural equation modeling, [SHS]Humanities and Social Sciences, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Cognition, Elderly, medicine, Humans, Cognitive Dysfunction, Depression (differential diagnoses), ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, business.industry, Depression, Middle Aged, medicine.disease, 3. Good health, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Schizophrenia, Older adults, Cohort, Female, Schizophrenic Psychology, business, 030217 neurology & neurosurgery, Clinical psychology, Schizophrenia spectrum
Abstract

Little is known about the respective effects of depression and cognitive impairment on quality of life among older adults with schizophrenia spectrum disorder.We used data from the Cohort of individuals with Schizophrenia Aged 55-years or more (CSA) study, a large multicenter sample of older adults with schizophrenia or schizoaffective disorder (N = 353). Quality of life (QoL), depression and cognitive impairment were assessed using the Quality of Life Scale (QLS), the Center of Epidemiologic Studies Depression scale and the Mini-Mental State Examination, respectively. We used structural equation modeling to examine the shared and specific effects of depression and cognitive impairment on QoL, while adjusting for sociodemographic characteristics, general medical conditions, psychotropic medications and the duration of the disorder.Depression and cognitive impairment were positively associated (r = 0.24, p 0.01) and both independently and negatively impacted on QoL (standardized β = -0.41 and β = -0.32, both p 0.01) and on each QLS quality-of-life domains, except for depression on instrumental role and cognitive impairment on interpersonal relations in the sensitivity analyses excluding respondents with any missing data. Effects of depression and cognitive impairment on QoL were not due to specific depressive symptoms or specific cognitive domains, but rather mediated through two broad dimensions representing the shared effects across all depressive symptoms and all cognitive deficits, respectively.Because of the cross-sectional design of this study, measures of association do not imply causal associations.Mechanisms underlying these two broad dimensions should be considered as important potential targets to improve quality of life of this vulnerable population.

Published
2019
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