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Introdução e objetivo: Toda atividade física requer preparo para um desempenho máximo. Sendo assim, o objetivo deste estudo foi verificar qual o tipo de aquecimento é mais eficiente para o desempenho da força máxima (1 RM). Materiais e métodos: Participaram deste estudo 10 indivíduos do sexo masculino com idade média entre 25 a 35 anos. Foram utilizados quatro tipos diferentes de aquecimento: específico, orgânico, alongamento estático e sem aquecimento. A força máxima foi medida utilizando-se dois exercícios em aparelhos de musculação: supino reto e leg press 45º. Os dados foram analisados através da estatística descritiva (média e desvio padrão). Para a comparação entre os diferentes tipos de aquecimento sobre o teste de 1RM foi utilizado o teste t pareado tendo em vista ser sempre os mesmos indivíduos. Todas as análises foram realizadas no SPSS for Windows 20.0, sendo que o nível de significância adotado foi de 5%. Resultados e discussão: Os resultados demonstraram que, para o supino reto, o aquecimento especifico foi o mais eficaz, enquanto que no leg press 45º o aquecimento orgânico foi o que demonstrou melhor eficácia. Por outro lado, a não realização de aquecimento prévio foi o que apresentou menor eficácia na execução dos dois exercícios propostos. Conclusão: Concluímos então que houve uma influência no desempenho de força de acordo com o aquecimento realizado. Palavras-chave: Exercício de Aquecimento. Treinamento de Resistência. Força Muscular. Desempenho Atlético. 1-Universidade Luterana do Brasil-ULBRA, Canoas-RS, Brasil. 2-Laboratório de Fisiologia e Medicina do Esporte-LAFIMED, Universidade Luterana do Brasil-ULBRA, Canoas-RS, Brasil. ABSTRACT Effects of different warm-up exercise in the strength evaluation. Introduction and Purpose: Every physical activity requires preparation for maximum performance. Thus, the aim of this study was to determine what type of warm-up exercise is more efficient to perform the maximum strength (1RM). Methods: The study included 10 males with an average age between 25-35 years. We used four different types of warm-up exercise: specific, organic, and unheated static stretching. The maximum strength was measured using two exercises on resistance training machines: bench press and leg press 45. Data were analyzed using descriptive statistics (mean and standard deviation). To compare the different types of warm-up exercise on the 1RM test was used paired t test in order to always be the same individuals. All analyzes were performed using SPSS for Windows 20.0, and the significance level was 5%. Results and discussion: The results showed that for the bench press, the specific warm-up exercise was the most effective, while in the leg press 45 organic warm-up exercise was what showed better efficacy. On the other hand, the failure to carry out preheating showed the lower efficiency of the enforcement of the two proposed exercises. Conclusion: We concluded that there was an influence on the strength of performance in accordance with the warm-up exercise performed.

Abstract: BACKGROUND: Permanent alopecia after bone marrow transplantation is rare, but more and more cases have been described, typically involving high doses of chemotherapeutic agents used in the conditioning regimen for the transplant. Busulfan, classically described in cases of irreversible alopecia, remains associated in recent cases. The pathogenesis involved in hair loss is not clear and there are few studies available. In addition to chemotherapeutic agents, another factor that has been implicated as a cause is chronic graft-versus-host disease. However, there are no histopathological criteria for defining this diagnosis yet. OBJECTIVE: the study aims to evaluate clinical and histological aspects in cases of permanent alopecia after bone marrow transplantation, identifying features of permanent alopecia induced by myeloablative chemotherapy and alopecia as a manifestation of chronic graft-versus-host disease. METHODS: data were collected from medical records of 7 patients, with description of the clinical features and review of slides and paraffin blocks of biopsies. RESULTS: Two distinct histological patterns were found: one similar to androgenetic alopecia, non-scarring pattern, and other similar to lichen planopilaris, scarring alopecia. CONCLUSION: The first pattern corroborates the literature cases of permanent alopecia induced by chemotherapeutic agents, and the second is compatible with manifestation of chronic graft-versus-host disease on scalp, that has never been described yet. The results contribute to the elucidation of the factors involved in these cases, including the development of therapeutic methods

The epidemic, caused by SARS-CoV-2 at the beginning of 2020, led us to a serious change in our lifestyle that for about three months has confined us to our homes, far from our laboratory routine. In this period, the belief that the work of a researcher should never stop has been the driving force in writing the present paper. It aims at reviewing the recent scientific knowledge about in vitro experimental data that focused on the antiviral role of phenols and polyphenols against different species of coronaviruses (CoVs), pointing up the viral targets potentially involved. In the current literature scenario, the papain-like and the 3-chymotrypsin-like proteases seem to be the most deeply investigated and a number of isolated natural (poly)phenols has been screened for their efficacy.

After a long period defined by prohibition of hemp production, this crop has been recently re-evaluated in various industrial sectors. Until now, inflorescences have been considered a processing by-product, not useful for the food industry, and their disposal also represents an economic problem for farmers. The objects of the present work are coffee blends enriched with shredded inflorescences of different cultivars of industrial hemp that underwent solid/liquid extraction into the Italian “moka” coffee maker. The obtained coffee drinks were analyzed by Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS) tools for their quali-quantitative phytocannabinoid profiles. The results showed that they are minor constituents compared to chlorogenic acids and caffeine in all samples. In particular, cannabidiolic acid was the most abundant among phytocannabinoids, followed by tetrahydrocannabinolic acid. Neither Δ9-tetrahydrocannabinol (THC) nor cannabinol, its main oxidation product, were detected. The percentage of total THC never exceeded 0.04%, corresponding to 0.4 mg/kg, far below the current maximum limits imposed by the Italian Ministry of Health. This study opens up a new concrete possibility to exploit hemp processing by-products in order to obtain drinks with high added value and paves the way for further in vitro and in vivo investigations aimed at promoting their benefits for human health.

Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp (Cannabis sativa L.) plants, but its potential health-related capabilities have been masked for years by a greater scientific interest towards its neutral derivative cannabidiol (CBD). This review aims to collect from the literature and critically discuss all the information about this molecule, starting from its biosynthesis, and focusing on its bioactivity, as an anti-inflammatory, anti-emetic, anti-convulsant, and anti-cancerogenic drug. Furthermore, in the awareness that, despite its multiple bioactive effects, currently poor efforts have been made to achieve its reliable purification, herein, we propose a relatively simple, fast, and inexpensive procedure for its recovery from pollen of industrial hemp cultivars. Spectroscopic and spectrometric techniques allowed us to unequivocally identify pure isolated CBDA and to distinguish it from the constitutional isomer tetrahydrocannabinolic acid (THCA-A).

Marketed green teas (GTs) can highly vary in their chemical composition, due to different origins, processing methods, and a lack of standardization of GT-based products. Consequently, biological activities become difficult to correlate to the presence/content of certain constituents. Herein, ultra-high-performance liquid chromatography (UHPLC) combined with high-resolution tandem mass spectrometry (HR MS/MS) was successfully applied to six commercial GT products, extracted by ethanol sonication, to disclose their polyphenol profile beyond the well-known catechins. The relative abundance of each class of metabolites was correlated to antiradical and antilipoperoxidant data through hierarchical clustering analysis, since it reasonably affects the beneficial properties of the product that reaches the consumer. The thiobarbituric acid reactive substances (TBARS) assay demonstrated that GT extracts effectively counteracted the UV-induced lipoperoxidation of hemp oil, which is highly rich in Polyunsaturated Fatty Acids (PUFAs), and therefore highly unstable. The Relative Antioxidant Capacity Index (RACI) comprehensively emphasized that gunpower and blend in filter GTs appeared to be the less active matrices, and except for a GT-based supplement, the Sencha GT, which was particularly rich in flavonol glycosides, was the most active, followed by Bancha GT.

The weak but noteworthy presence of (poly)phenols in hemp seeds has been long overshadowed by the essential polyunsaturated fatty acids and digestible proteins, considered responsible for their high nutritional benefits. Instead, lignanamides and their biosynthetic precursors, phenylamides, seem to display interesting and diverse biological activities only partially clarified in the last decades. Herein, negative mode HR-MS/MS techniques were applied to the chemical investigation of a (poly)phenol-rich fraction, obtained from hemp seeds after extraction/fractionation steps. This extract contained phenylpropanoid amides and their random oxidative coupling derivatives, lignanamides, which were the most abundant compounds and showed a high chemical diversity, deeply unraveled through high resolution tandem mass spectrometry (HR-MS/MS) tools. The effect of different doses of the lignanamides-rich extract (LnHS) on U-87 glioblastoma cell line and non-tumorigenic human fibroblasts was evaluated. Thus, cell proliferation, genomic DNA damage, colony forming and wound repair capabilities were assessed, as well as LnHS outcome on the expression levels of pro-inflammatory cytokines. LnHS significantly inhibited U-87 cancer cell proliferation, but not that of fibroblasts, and was able to reduce U-87 cell migration, inducing further DNA damage. No modification in cytokines’ expression level was found. Data acquired suggested that LnHS acted in U-87 cells by inducing the apoptosis machinery and suppressing the autophagic cell death.

We consider a quantum battery modelled as a set of N independent two-level quantum systems driven by a time dependent classical source. Different figures of merit, such as stored energy, time of charging and energy quantum fluctuations during the charging process, are characterized in a wide range of parameters, by means of numerical approach and suitable analytical approximation scheme. Particular emphasis is put on the role of different initial conditions, describing the preparation state of the quantum battery, as well as on the sensitivity to the functional form of the external time-dependent drive. It is shown that an optimal charging protocol, characterized by fast charging time and the absence of charging fluctuations, can be achieved starting from the ground state of each two-level system, while other pure preparation states are less efficient. Moreover, we argue that a periodic train of peaked rectangular pulses can lead to fast charging. This study aims at providing a useful theoretical background in view of future experimental solid-state implementations.

Coupling with an external environment inevitably affects the dynamics of a quantum system. Here, we consider how charging performances of a quantum battery, modelled as a two level system, are influenced by the presence of an Ohmic thermal reservoir. The latter is coupled to both longitudinal and transverse spin components of the quantum battery including decoherence and pure dephasing mechanisms. Charging and discharging dynamics of the quantum battery, subjected to a static driving, are obtained exploiting a proper mapping into the so-called spin-boson model. Analytic expressions for the time evolution of the energy stored in the weak coupling regime are presented relying on a systematic weak damping expansion. Here, decoherence and pure dephasing dissipative coupling are discussed in details. We argue that the former results in better charging performances, showing also interesting features reminiscent of the Lamb shift level splitting renormalization induced by the presence of the reservoir. Charging stability is also addressed, by monitoring the energy behaviour after the charging protocol has been switched off. This study presents a general framework to investigate relaxation effects, able to include also non Markovian effects, and it reveals the importance of controlling and, possibly, engineering system-bath coupling in the realization of quantum batteries.

CloudVeneto.it was initially funded and deployed by INFN in 2014 for serving the computational and storage demands of INFN research projects mainly related to HEP and Nuclear Physics. It is an OpenStack-based scientific cloud with resources spread across two different sites connected with a high speed optical link: INFN Padova Unit and the INFN Legnaro National Laboratories. The infrastructure has grown throughout the years with additional funds from ten University of Padova departments, and nowadays supports a broader range of scientific and engineering disciplines. Its hardware resources provide around 2500 computational cores and 360 TB of storage to about 250 users working for more than 70 projects. In the last months we enhanced the cloud platform in two ways: 1) by integrating a number of heterogeneous GPU cards to address the special needs of user communities whose computations involve machine learning training; 2) by enabling the users to simply deploy on-demand Kubernetes clusters for Big Data Analytics applications taking advantage of the operator framework. In particular, the Kubernetes operators for Apache Kafka and Spark platforms were integrated to address real-time data ingestion and streaming processing on the cloud. This article describes the technical details of these two solutions and their integration with the cloud infrastructure.

Las cardiopatías congénitas incluyen anomalias en la estructura cardiaca que ocurren antes del nacimiento. Dichos defectos se dan en el feto mientras se desarrolla durante el embarazo. Este grupo de pacientes son de riesgo para contraer endocarditis infecciosa durante la consulta odontológica. Objetivo: recopilar información actualizada sobre el control odontológico para prevenir la endocarditis infecciosa en niños y adolescentes que presenten cardiopatías congénitas. Materiales y Métodos: se realizó una búsqueda, mediante consulta electrónica en las principales bases de datos científicas Pubmed, Lilacs, Scielo, Medline, EBSCO desde 1990 a 2017 en inglés, español y portugués. Conclusión: De acuerdo a las últimas pautas mundiales cada paciente debe ser tratado de acuerdo al riesgo real de desarrollar o no EI y no debe impartirse la profilaxis antibiótica como se hacía en el pasado.

The title compound, C11H9NO, crystallizes with two molecules, A and B, with similar conformations (r.m.s. overlay fit = 0.030 Å) in the asymmetric unit: the C—C=N...O torsion angles are −177.8 (3) and −179.1 (3)°. In the crystal, molecules are linked by alternating O—H...N (A → B) and O—H...O (B → A) hydrogen bonds to generate [100] chains. A weak C—H...O interaction is also observed.

This study evaluated epidemiological factors for HCV infection associated with sharing perforating and cutting instruments among candidates for blood donation (CBD) in the city of Belém, Pará, Brazilian Amazon. Two definitions of HCV infection cases were used: anti-HCV positivity shown by EIA, and HCV-RNA detection by PCR. Infected and uninfected CBD completed a questionnaire about possible risk factors associated with sharing perforating and cutting instruments. The information was evaluated using simple and multiple logistic regressions. Between May and November 2010, 146 (1.1%) persons with anti-HCV antibodies and 106 (0.8%) with HCV-RNA were detected among 13,772 CBD in Belém. Risk factors associated with HCV infection based on the EIA (model 1) and PCR (model 2) results were: use of needles and syringes sterilized at home; shared use of razors at home, sharing of disposable razors in barbershops, beauty salons etc.; and sharing manicure and pedicure material. The models of HCV infection associated with sharing perforating and cutting instruments should be taken into account by local and regional health authorities and by those of other countries with similar cultural practices, in order to provide useful information to guide political and public strategies to control HCV transmission.

Introduction: Illicit drug users (DUs) are vulnerable to hepatitis C virus (HCV) infection. The shared use of illicit drugs is the main method of HCV transmission. Methods: A cross-sectional study was conducted in Breves, in northern Brazil. We surveyed 187 DUs to determine the prevalence of and factors associated with HCV infection. Results: The prevalence of anti-HCV antibodies was 36.9%, and the prevalence of hepatitis C virus-ribonucleic acid (HCV-RNA) was 31%. Hepatitis C virus infection was associated with tattoos, intravenous drug use, shared use of equipment for drug use, drug use for longer than 3 years, and daily drug use. Conclusions: Strategies for preventing and controlling HCV transmission should be implemented among DUs.

Leaves of Vitis vinifera cv. Greco di Tufo, a precious waste made in the Campania Region (Italy), after vintage harvest, underwent reduction, lyophilization, and ultrasound-assisted maceration in ethanol. The alcoholic extract, as evidenced by a preliminary UHPLC-HR-MS analysis, showed a high metabolic complexity. Thus, the extract was fractionated, obtaining, among others, a fraction enriched in flavonol glycosides and glycuronides. Myricetin, quercetin, kaempferol, and isorhamnetin derivatives were tentatively identified based on their relative retention time and TOF-MS2 data. As the localization of saccharidic moiety in glycuronide compounds proved to be difficult due to the lack of well-established fragmentation pattern and/or the absence of characteristic key fragments, to obtain useful MS information and to eliminate matrix effect redundancies, the isolation of the most abundant extract’s compound was achieved. HR-MS/MS spectra of the compound, quercetin-3-O-glucuronide, allowed us to thoroughly rationalize its fragmentation pattern, and to unravel the main differences between MS/MS behavior of flavonol glycosides and glycuronides. Furthermore, cytotoxicity assessment on the (poly)phenol rich fraction and the pure isolated compound was carried out using central nervous system cell lines. The chemoprotective effect of both the (poly)phenol fraction and quercetin-3-O-glucuronide was evaluated.