17,160 results on '"Cooper, J."'
Search Results
152. Protocol Compliance Guiding Angiotensin II Use in Post Cardiovascular Surgery Vasoplegia
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Caitlin C. ten Lohuis, MSN, ACNP-BC, Sarah C. Burke, MD, Cooper J. Jannuzzo, MS, Nicholas A. Barker, PharmD, Edward P. Chen, MD, and Laurence W. Busse, MD, MBA, FCCM
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
OBJECTIVES:. Catecholamines and vasopressin are commonly used in patients with post cardiovascular surgery vasoplegia (PCSV). Multimodal therapy, including methylene blue (MB), hydroxocobalamin, and angiotensin II (Ang II), may improve outcomes in patients who remain hypotensive despite catecholamine and vasopressin therapy. However, a standardized approach has not been established. We created a protocol at Emory Healthcare (Emory Protocol), which provides guidance on norepinephrine equivalent dose (NED) and the use of noncatecholamines in the setting of PCSV and sought to determine the clinical significance of adherence to the protocol. DESIGN:. Retrospective study. SETTING:. Multisite study at Emory University Hospital. PATIENTS:. Patients receiving Ang II for PCSV in any cardiovascular ICU from 2018 to 2020. INTERVENTIONS:. Patient encounters were scored on Emory Protocol compliance based on NED (1–5), use of vasopressin (1–2), use of MB (1–2), and documentation of high-output shock (1–4). A compliant score was less than 7, moderately compliant 7 to 8, and poorly compliant greater than 8. Demographics, clinical data, and outcomes were abstracted from the medical records. MEASUREMENTS AND MAIN RESULTS:. Of the 78 consecutive patients receiving Ang II for PCSV, overall ICU mortality was 26.9%, with an average compliance score of 6.2. ICU mortality was 21.1% for compliant cases (n = 38), 29.7% for moderately compliant cases (n = 24), and 37.5% for poorly compliant cases (n = 16). In regression analysis, the cumulative compliance score to the Emory Protocol was predictive of ICU mortality (p = 0.027). CONCLUSIONS:. Compliance with the Emory Protocol, emphasizing early initiation of the noncatecholamines vasopressin, MB, hydroxocobalamin, and Ang II at lower catecholamine doses in high-output shock, is associated with improved ICU mortality.
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- 2022
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153. Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-analysis
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Leitao Filho, Fernando Sergio, Mattman, Andre, Schellenberg, Robert, Criner, Gerard J., Woodruff, Prescott, Lazarus, Stephen C., Albert, Richard K., Connett, John, Han, Meilan K., Gay, Steven E., Martinez, Fernando J., Fuhlbrigge, Anne L., Stoller, James K., MacIntyre, Neil R., Casaburi, Richard, Diaz, Philip, Panos, Ralph J., Cooper, J. Allen, Jr., Bailey, William C., LaFon, David C., Sciurba, Frank C., Kanner, Richard E., Yusen, Roger D., Au, David H., Pike, Kenneth C., Fan, Vincent S., Leung, Janice M., Man, Shu-Fan Paul, Aaron, Shawn D., Reed, Robert M., and Sin, Don D.
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- 2020
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154. Use of mobile applications to improve nutrition behaviour: A systematic review
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Paramastri, Rathi, Pratama, Satwika Arya, Ho, Dang Khanh Ngan, Purnamasari, Sintha Dewi, Mohammed, Afrah Zaki, Galvin, Cooper J, Hsu, Yi-Hsin Elsa, Tanweer, Afifa, Humayun, Ayesha, Househ, Mowafa, and Iqbal, Usman
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- 2020
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155. Evaluating the immediate effect of forearm and wrist orthoses on pain and function in individuals with lateral elbow tendinopathy: A systematic review
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Heales, Luke J., McClintock, Stacy R., Maynard, Sabrina, Lems, Cooper J., Rose, Jordan A., Hill, Caitlin, Kean, Crystal O., and Obst, Steven
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- 2020
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156. The instrument suite of the European Spallation Source
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Andersen, K.H., Argyriou, D.N, Jackson, A.J., Houston, J., Henry, P.F., Deen, P.P., Toft-Petersen, R., Beran, P., Strobl, M., Arnold, T., Wacklin-Knecht, H., Tsapatsaris, N., Oksanen, E., Woracek, R., Schweika, W., Mannix, D., Hiess, A., Kennedy, S., Kirstein, O., Petersson Årsköld, S., Taylor, J., Hagen, M.E., Laszlo, G., Kanaki, K., Piscitelli, F., Khaplanov, A., Stefanescu, I., Kittelmann, Th., Pfeiffer, D., Hall-Wilton, R., Lopez, C.I., Aprigliano, G., Whitelegg, L., Moreira, F.Y., Olsson, M., Bordallo, H.N., Martín-Rodríguez, D., Schneider, H., Sharp, M., Hartl, M., Nagy, G., Ansell, S., Pullen, S., Vickery, A., Fedrigo, A., Mezei, F., Arai, M., Heenan, R.K., Halcrow, W., Turner, D., Raspino, D., Orszulik, A., Cooper, J., Webb, N., Galsworthy, P., Nightingale, J., Langridge, S., Elmer, J., Frielinghaus, H., Hanslik, R., Gussen, A., Jaksch, S., Engels, R., Kozielewski, T., Butterweck, S., Feygenson, M., Harbott, P., Poqué, A., Schwaab, A., Lieutenant, K., Violini, N., Voigt, J., Brückel, T., Koenen, M., Kämmerling, H., Babcock, E., Salhi, Z., Wischnewski, A., Heynen, A., Désert, S., Jestin, J., Porcher, F., Fabrèges, X., Fabrèges, G., Annighöfer, B., Klimko, S., Dupont, Th., Robillard, Th., Goukassov, A., Longeville, S., Alba-Simionesco, Ch., Bourges, Ph., Guyon Le Bouffy, J., Lavie, P., Rodrigues, S., Calzada, E., Lerche, M., Schillinger, B., Schmakat, Ph., Schulz, M., Seifert, M., Lohstroh, W., Petry, W., Neuhaus, J., Loaiza, L., Tartaglione, A., Glavic, A., Schütz, S., Stahn, J., Lehmann, E., Morgano, M., Schefer, J., Filges, U., Klauser, Ch., Niedermayer, Ch., Fenske, J., Nowak, G., Rouijaa, M., Siemers, D.J., Kiehn, R., Müller, M., Carlsen, H., Udby, L., Lefmann, K., Birk, J.O., Holm-Dahlin, S., Bertelsen, M., Hansen, U. Bengaard, Olsen, M.A., Christensen, M., Iversen, K., Christensen, N.B., Rønnow, H.M., Freeman, P.G., Hauback, B.C., Kolevatov, R., Llamas-Jansa, I., Orecchini, A., Sacchetti, F., Petrillo, C., Paciaroni, A., Tozzi, P., Zanatta, M., Luna, P., Herranz, I., del Moral, O.G., Huerta, M., Magán, M., Mosconi, M., Abad, E., Aguilar, J., Stepanyan, S., Bakedano, G., Vivanco, R., Bustinduy, I., Sordo, F., Martínez, J.L., Lechner, R.E., Villacorta, F.J., Šaroun, J., Lukáš, P., Markó, M., Zanetti, M., Bellissima, S., del Rosso, L., Masi, F., Bovo, C., Chowdhury, M., De Bonis, A., Di Fresco, L., Scatigno, C., Parker, S.F., Fernandez-Alonso, F., Colognesi, D., Senesi, R., Andreani, C., Gorini, G., Scionti, G., and Schreyer, A.
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- 2020
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157. A84 COMPETENCY BASED MEDICAL EDUCATION: O-SCORE CHARACTERISTICS OF PROCEDURAL AND COGNITIVE ASSESSMENTS IN GASTROENTEROLOGY RESIDENCY TRAINING
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Cooper, J, primary, Gozdzik, M, additional, Silverman, J, additional, and Kroeker, K, additional
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- 2024
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158. An fMRI dataset of social and nonsocial reward processing in young adults
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Smith, David V., primary, Wyngaarden, James, additional, Sharp, Cooper J., additional, Sazhin, Daniel, additional, Zaff, Ori, additional, Fareri, Dominic, additional, and Jarcho, Johanna, additional
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- 2024
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159. A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation
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Albert, Richard K, Au, David H, Blackford, Amanda L, Casaburi, Richard, Cooper, J Allen, Criner, Gerard J, Diaz, Philip, Fuhlbrigge, Anne L, Gay, Steven E, Kanner, Richard E, MacIntyre, Neil, Martinez, Fernando J, Panos, Ralph J, Piantadosi, Steven, Sciurba, Frank, Shade, David, Stibolt, Thomas, Stoller, James K, Wise, Robert, Yusen, Roger D, Tonascia, James, Sternberg, Alice L, and Bailey, William
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Rehabilitation ,Lung ,Clinical Trials and Supportive Activities ,Chronic Obstructive Pulmonary Disease ,Clinical Research ,6.7 Physical ,Evaluation of treatments and therapeutic interventions ,Respiratory ,Aged ,Exercise ,Exercise Tolerance ,Female ,Follow-Up Studies ,Hospitalization ,Humans ,Kaplan-Meier Estimate ,Male ,Middle Aged ,Oxygen ,Oxygen Inhalation Therapy ,Patient Compliance ,Pulmonary Disease ,Chronic Obstructive ,Quality of Life ,Time Factors ,Treatment Failure ,Long-Term Oxygen Treatment Trial Research Group ,Medical and Health Sciences ,General & Internal Medicine - Abstract
BackgroundLong-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation.MethodsWe originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo2], 89 to 93%). After 7 months and the randomization of 34 patients, the trial was redesigned to also include patients who had stable COPD with moderate exercise-induced desaturation (during the 6-minute walk test, Spo2 ≥80% for ≥5 minutes and
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- 2016
160. First Measurement of Electron Neutrino Appearance in NOvA
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Adamson, P, Ader, C, Andrews, M, Anfimov, N, Anghel, I, Arms, K, Arrieta-Diaz, E, Aurisano, A, Ayres, DS, Backhouse, C, Baird, M, Bambah, BA, Bays, K, Bernstein, R, Betancourt, M, Bhatnagar, V, Bhuyan, B, Bian, J, Biery, K, Blackburn, T, Bocean, V, Bogert, D, Bolshakova, A, Bowden, M, Bower, C, Broemmelsiek, D, Bromberg, C, Brunetti, G, Bu, X, Butkevich, A, Capista, D, Catano-Mur, E, Chase, TR, Childress, S, Choudhary, BC, Chowdhury, B, Coan, TE, Coelho, JAB, Colo, M, Cooper, J, Corwin, L, Cronin-Hennessy, D, Cunningham, A, Davies, GS, Davies, JP, Del Tutto, M, Derwent, PF, Deepthi, KN, Demuth, D, Desai, S, Deuerling, G, Devan, A, Dey, J, Dharmapalan, R, Ding, P, Dixon, S, Djurcic, Z, Dukes, EC, Duyang, H, Ehrlich, R, Feldman, GJ, Felt, N, Fenyves, EJ, Flumerfelt, E, Foulkes, S, Frank, MJ, Freeman, W, Gabrielyan, M, Gallagher, HR, Gebhard, M, Ghosh, T, Gilbert, W, Giri, A, Goadhouse, S, Gomes, RA, Goodenough, L, Goodman, MC, Grichine, V, Grossman, N, Group, R, Grudzinski, J, Guarino, V, Guo, B, Habig, A, Handler, T, Hartnell, J, Hatcher, R, Hatzikoutelis, A, Heller, K, Howcroft, C, Huang, J, Huang, X, Hylen, J, Ishitsuka, M, Jediny, F, Jensen, C, Jensen, D, Johnson, C, Jostlein, H, and Kafka, GK
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NOvA Collaboration ,hep-ex ,physics.ins-det ,Mathematical Sciences ,Physical Sciences ,Engineering ,General Physics - Abstract
We report results from the first search for ν_{μ}→ν_{e} transitions by the NOvA experiment. In an exposure equivalent to 2.74×10^{20} protons on target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of 0.99±0.11(syst) events based on the Near Detector measurement. A secondary analysis observes 11 events with a background of 1.07±0.14(syst). The 3.3σ excess of events observed in the primary analysis disfavors 0.1π
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- 2016
161. First measurement of muon-neutrino disappearance in NOvA
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Adamson, P, Ader, C, Andrews, M, Anfimov, N, Anghel, I, Arms, K, Arrieta-Diaz, E, Aurisano, A, Ayres, DS, Backhouse, C, Baird, M, Bambah, BA, Bays, K, Bernstein, R, Betancourt, M, Bhatnagar, V, Bhuyan, B, Bian, J, Biery, K, Blackburn, T, Bocean, V, Bogert, D, Bolshakova, A, Bowden, M, Bower, C, Broemmelsiek, D, Bromberg, C, Brunetti, G, Bu, X, Butkevich, A, Capista, D, Catano-Mur, E, Chase, TR, Childress, S, Choudhary, BC, Chowdhury, B, Coan, TE, Coelho, JAB, Colo, M, Cooper, J, Corwin, L, Cronin-Hennessy, D, Cunningham, A, Davies, GS, Davies, JP, Del Tutto, M, Derwent, PF, Deepthi, KN, Demuth, D, Desai, S, Deuerling, G, Devan, A, Dey, J, Dharmapalan, R, Ding, P, Dixon, S, Djurcic, Z, Dukes, EC, Duyang, H, Ehrlich, R, Feldman, GJ, Felt, N, Fenyves, EJ, Flumerfelt, E, Foulkes, S, Frank, MJ, Freeman, W, Gabrielyan, M, Gallagher, HR, Gebhard, M, Ghosh, T, Gilbert, W, Giri, A, Goadhouse, S, Gomes, RA, Goodenough, L, Goodman, MC, Grichine, V, Grossman, N, Group, R, Grudzinski, J, Guarino, V, Guo, B, Habig, A, Handler, T, Hartnell, J, Hatcher, R, Hatzikoutelis, A, Heller, K, Howcroft, C, Huang, J, Huang, X, Hylen, J, Ishitsuka, M, Jediny, F, Jensen, C, Jensen, D, Johnson, C, Jostlein, H, and Kafka, GK
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hep-ex ,physics.ins-det - Abstract
This paper reports the first measurement using the NOvA detectors of νμ disappearance in a νμ beam. The analysis uses a 14 kton-equivalent exposure of 2.74×1020 protons-on-target from the Fermilab NuMI beam. Assuming the normal neutrino mass hierarchy, we measure Δm322=(2.52-0.18+0.20)×10-3 eV2 and sin2θ23 in the range 0.38-0.65, both at the 68% confidence level, with two statistically degenerate best-fit points at sin2θ23=0.43 and 0.60. Results for the inverted mass hierarchy are also presented.
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- 2016
162. Thermoelectric power of overdoped Tl2201 crystals: charge density waves and T 1 and T 2 resistivities
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Cooper, J R, primary, Baglo, J C, additional, Putzke, C, additional, and Carrington, A, additional
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- 2023
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163. Controlled suppression of superconductivity by the generation of polarized Cooper pairs in spin valve structures
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Flokstra, M. G., Cunningham, T. C., Kim, J., Satchell, N., Burnell, G., Bending, S. J., Curran, P. J., Langridge, S. J., Kinane, C., Cooper, J. F. K., Pugach, N., Eschrig, M., and Lee, S. L.
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Condensed Matter - Superconductivity - Abstract
Transport measurements are presented on thin-film superconducting spin-valve systems, where the controlled non-collinear arrangement of two ferromagnetic Co layers can be used to influence the superconducting state of Nb. We observe a very clear oscillation of the superconducting transition temperature with the relative orientation of the two ferromagnetic layers. Our measurements allow us to distinguish between the competing influences of domain averaging, stray dipolar fields and the formation of superconducting spin triplets. Domain averaging is shown to lead to a weak enhancement of transition temperature for the anti-parallel configuration of exchange fields, while much larger changes are observed for other configurations, which can be attributed to drainage currents due to spin triplet formation., Comment: 5 pages, 4 figures
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- 2014
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164. The pseudogap in YBa$_2$Cu$_3$O$_{6+\delta}$ is not bounded by a line of phase transitions - thermodynamic evidence
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Cooper, J. R., Loram, J. W., Kokanović, I., Storey, J. G., and Tallon, J. L.
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Condensed Matter - Superconductivity - Abstract
We discuss a recent resonant ultrasound spectroscopy (RUS) study of YBa$_2$Cu$_3$O$_{6+\delta}$, which infers a line of phase transitions bounding the pseudogap phase and argue that this scenario is not supported by thermodynamic evidence. We show that the anomalies in RUS, heat capacity and thermal expansion at the superconducting transition temperatures agree well. But there are large discrepancies between RUS and thermodynamic measurements at $T^*$ where the pseudogap phase transitions are purported to occur. Moreover, the frequency and temperature dependence of the RUS data for the crystal with $\delta = 0.98$, interpreted in terms of critical slowing down near an electronic phase transition, is five orders of magnitude smaller than what is expected. For this crystal the RUS data near $T^*$ are more consistent with non-equilibrium effects such as oxygen relaxation., Comment: Published version
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- 2014
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165. Planning the Future of U.S. Particle Physics (Snowmass 2013): Chapter 8: Instrumentation Frontier
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Demarteau, M., Lipton, R., Nicholson, H., Shipsey, I., Akerib, D., Albayrak-Yetkin, A., Alexander, J., Anderson, J., Artuso, M., Asner, D., Ball, R., Battaglia, M., Bebek, C., Beene, J., Benhammou, Y., Bentefour, E., Bergevin, M., Bernstein, A., Bilki, B., Blucher, E., Bolla, G., Bortoletto, D., Bowden, N., Brooijmans, G., Byrum, K., Cabrera, B., Cancelo, G., Carlstrom, J., Casey, B., Chang, C., Chapman, J., Chen, C. H., Childres, I., Christian, D., Convery, M., Corso, W. Cooper J., Cumalat, J., Cushman, P., Da Via, C., Dazeley, S., Debbins, P., Deptuch, G., Dhawan, S., Di Benedetto, V., DiGiovene, B., Djurcic, Z., Dye, S., Elagin, A., Estrada, J., Evans, H., Etzion, E., Fast, J., Ferretti, C., Fisher, P., Fleming, B., Francis, K., Friedman, P., Frisch, H., Garcia-Sciveres, M., Gatto, C., Geronim, G., Gilchriese, G., Golwala, S., Grant, C., Grillo, A., Grünendahl, E., Gorham, P., Guan, L., Gutierrez, G., Haber, C., Hall, J., Haller, G., Hast, C., Heintz, U., Hemmick, T., Hitlin, D. G., Hogan, C., Hohlmann, M., Hoppe, E., Hsu, L., Huffer, M., Irwin, K., Izraelevitch, F., Jennings, G., Johnson, M., Jung, A., Kagan, H., Kenney, C., Kettell, S., Khanna, R., Khristenko, V., Krennrich, F., Kuehn, K., Kutschke, R., Learned, J., Lee, A. T., Levin, D., Liu, T., Liu, A. T. K., Lissauer, D., Love, J., Lynn, D., MacFarlane, D., Magill, S., Majewski, S., Mans, J., Maricic, J., Marleau, P., Mazzacane, A., McKinsey, D., Mehl, J., Mestvirisvilli, A., Meyer, S., Mokhov, N., Moshe, M., Mukherjee, A., Murat, P., Nahn, S., Narain, M., Nadel-Turonski, P., Newcomer, M., Nishimura, K., Nygren, D., Oberla, E., Onel, Y., Oreglia, M., Orrell, J., Paley, J., Para, A., Parker, S., Polychronakos, V., Pordes, S., Privitera, P., Prosser, A., Pyle, M., Raaf, J., Ramberg, E., Rameika, R., Rebel, B., Repond, J., Reyna, D., Ristori, L., Rivera, R., Ronzhin, A., Rusack, R., Russ, J., Ryd, A., Sadrozinski, H., Sahoo, H., Sanchez, M. C., Sanzeni, C., Schnetzer, S., Seidel, S., Seiden, A., Schmidt, I., Shenai, A., Shutt, T., Silver, Y., Smith, W., Snowden-Ifft, D., Sonnenschein, A., Southwick, D., Spiegel, L., Stanitzki, M., Striganov, S., Su, D., Sumner, R., Svoboda, R., Sweany, M., Talaga, R., Tayloe, R., Tentindo, S., Terentiev, N., Thom-Levy, J., Thorn, C., Tiffenberg, J., Trischuk, W., Tschirhart, R., Turner, M., Underwood, D., Uplegger, L., Urheim, J., Vagins, M., Van Bibber, K., Varner, G., Varner, R., Va'vra, J., Von der Lippe, H., Wagner, R., Wagner, S., Weaverdyck, C., Wenzel, H., Weinstein, A., Wetstein, M., White, A., Wigman, R., Wilson, P., Winn, D., Winter, P., Woody, C., Xia, L., Xie, J. Q., Ye, Z., Yeh, M. F., Yetkin, T., Yoo, J. H., Yu, J., Yu, J. M., Zeller, S., Zhang, J. L., Zhu, J. J., Zhou, B., Zhu, R. Y., and Zitzer, B.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Instrumentation and Detectors - Abstract
These reports present the results of the 2013 Community Summer Study of the APS Division of Particles and Fields ("Snowmass 2013") on the future program of particle physics in the U.S. Chapter 8, on the Instrumentation Frontier, discusses the instrumentation needs of future experiments in the Energy, Intensity, and Cosmic Frontiers, promising new technologies for particle physics research, and issues of gathering resources for long-term research in this area., Comment: 50 pages
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- 2014
166. Unexpected genomic, biosynthetic and species diversity of Streptomyces bacteria from bats in Arizona and New Mexico, USA
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Park, Cooper J., Caimi, Nicole A., Buecher, Debbie C., Valdez, Ernest W., Northup, Diana E., and Andam, Cheryl P.
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- 2021
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167. Rinosseros
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Cooper, J A
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- 2022
168. Protocol Compliance Guiding Angiotensin II Use in Post Cardiovascular Surgery Vasoplegia
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ten Lohuis, Caitlin C., Burke, Sarah C., Jannuzzo, Cooper J., Barker, Nicholas A., Chen, Edward P., and Busse, Laurence W.
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- 2022
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169. A Unified Curriculum
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Cooper, J. M., primary
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- 2021
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170. A compact multi-planet system around a bright nearby star from the Dispersed Matter Planet Project
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Staab, D., Haswell, C. A., Barnes, J. R., Anglada-Escudé, G., Fossati, L., Doherty, J. P. J., Cooper, J., Jenkins, J. S., Díaz, M. R., and Soto, M. G.
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- 2020
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171. Prognostic Models for Global Functional Outcome and Post-Concussion Symptoms Following Mild Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study
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Mikolic, A, Steyerberg, E, Polinder, S, Wilson, L, Zeldovich, M, von Steinbueche, N, Newcombe, V, Menon, D, van der Naalt, J, Lingsma, H, Maas, A, van Klaveren, D, Akerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Carbayo Lozano, G, Carbonara, M, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Fizelier, C, Dark, P, Dawes, H, De Keyser, V, Degos, V, Della Corte, F, den Boogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Kornaropoulos, E, Koskinen, L, Kovacs, N, Kowark, A, Lagares, A, Lanyon, L, Laureys, S, Lecky, F, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Castano Leon, A, Maegele, M, Majdan, M, Manara, A, Manley, G, Martino, C, Marechal, H, Mattern, J, Mcmahon, C, Melegh, B, Menovsky, T, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Nieboer, D, Nyiradi, J, Olubukola, O, Oresic, M, Ortolano, F, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Pisica, D, Ples, H, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Retel Helmrich, I, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez Porras, R, Sandor, J, Schafer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Stevens, R, Stewart, W, Stocchetti, N, Sundstrom, N, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Te Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Vallance, S, Valeinis, E, Vamos, Z, van Der Jagt, M, Van Der Steen, G, van Der Naalt, J, van Dijck, J, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, van Veen, E, Vande Vyvere, T, van Wijk, R, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Winzeck, S, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Zelinkova, V, Ziverte, A, Zoerle, T, Mikolic A., Steyerberg E. W., Polinder S., Wilson L., Zeldovich M., von Steinbueche N., Newcombe V. F. J., Menon D. K., van der Naalt J., Lingsma H. F., Maas A. I. R., van Klaveren D., Akerlund C., Amrein K., Andelic N., Andreassen L., Anke A., Antoni A., Audibert G., Azouvi P., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B. -M., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Carbayo Lozano G., Carbonara M., Cavallo S., Chevallard G., Chieregato A., Citerio G., Clusmann H., Coburn M., Coles J., Cooper J. D., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Fizelier C. D., Dark P., Dawes H., De Keyser V., Degos V., Della Corte F., den Boogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G. L., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P. A., Gratz J., Gravesteijn B., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Helbok R., Helseth E., Horton L., Huijben J., Hutchinson P. J., Jacobs B., Jankowski S., Jarrett M., Jiang J., Johnson F., Jones K., Karan M., Kolias A. G., Kompanje E., Kondziella D., Kornaropoulos E., Koskinen L. O., Kovacs N., Kowark A., Lagares A., Lanyon L., Laureys S., Lecky F., Ledoux D., Lefering R., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Castano Leon A. M., Maegele M., Majdan M., Manara A., Manley G., Martino C., Marechal H., Mattern J., McMahon C., Melegh B., Menon D., Menovsky T., Misset B., Muraleedharan V., Murray L., Negru A., Nelson D., Newcombe V., Nieboer D., Nyiradi J., Olubukola O., Oresic M., Ortolano F., Palotie A., Parizel P. M., Payen J. F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Pisica D., Ples H., Pomposo I., Posti J. P., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Retel Helmrich I., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roe C., Roise O., Rosand J., Rosenfeld J. V., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez Porras R., Sandor J., Schafer N., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stevens R., Stewart W., Stocchetti N., Sundstrom N., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Te Ao B., Tenovuo O., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Unterberg A., Vajkoczy P., Vallance S., Valeinis E., Vamos Z., van Der Jagt M., Van Der Steen G., van Der Naalt J., van Dijck J. T. J. M., van Essen T. A., Van Hecke W., van Heugten C., Van Praag D., van Veen E., Vande Vyvere T., van Wijk R. P. J., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K. W., Wiegers E., Williams G., Winzeck S., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F. A., Zelinkova V., Ziverte A., Zoerle T., Mikolic, A, Steyerberg, E, Polinder, S, Wilson, L, Zeldovich, M, von Steinbueche, N, Newcombe, V, Menon, D, van der Naalt, J, Lingsma, H, Maas, A, van Klaveren, D, Akerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Carbayo Lozano, G, Carbonara, M, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Fizelier, C, Dark, P, Dawes, H, De Keyser, V, Degos, V, Della Corte, F, den Boogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Kornaropoulos, E, Koskinen, L, Kovacs, N, Kowark, A, Lagares, A, Lanyon, L, Laureys, S, Lecky, F, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Castano Leon, A, Maegele, M, Majdan, M, Manara, A, Manley, G, Martino, C, Marechal, H, Mattern, J, Mcmahon, C, Melegh, B, Menovsky, T, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Nieboer, D, Nyiradi, J, Olubukola, O, Oresic, M, Ortolano, F, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Pisica, D, Ples, H, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Retel Helmrich, I, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez Porras, R, Sandor, J, Schafer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Stevens, R, Stewart, W, Stocchetti, N, Sundstrom, N, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Te Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Vallance, S, Valeinis, E, Vamos, Z, van Der Jagt, M, Van Der Steen, G, van Der Naalt, J, van Dijck, J, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, van Veen, E, Vande Vyvere, T, van Wijk, R, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Winzeck, S, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Zelinkova, V, Ziverte, A, Zoerle, T, Mikolic A., Steyerberg E. W., Polinder S., Wilson L., Zeldovich M., von Steinbueche N., Newcombe V. F. J., Menon D. K., van der Naalt J., Lingsma H. F., Maas A. I. R., van Klaveren D., Akerlund C., Amrein K., Andelic N., Andreassen L., Anke A., Antoni A., Audibert G., Azouvi P., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B. -M., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Carbayo Lozano G., Carbonara M., Cavallo S., Chevallard G., Chieregato A., Citerio G., Clusmann H., Coburn M., Coles J., Cooper J. D., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Fizelier C. D., Dark P., Dawes H., De Keyser V., Degos V., Della Corte F., den Boogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G. L., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P. A., Gratz J., Gravesteijn B., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Helbok R., Helseth E., Horton L., Huijben J., Hutchinson P. J., Jacobs B., Jankowski S., Jarrett M., Jiang J., Johnson F., Jones K., Karan M., Kolias A. G., Kompanje E., Kondziella D., Kornaropoulos E., Koskinen L. O., Kovacs N., Kowark A., Lagares A., Lanyon L., Laureys S., Lecky F., Ledoux D., Lefering R., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Castano Leon A. M., Maegele M., Majdan M., Manara A., Manley G., Martino C., Marechal H., Mattern J., McMahon C., Melegh B., Menon D., Menovsky T., Misset B., Muraleedharan V., Murray L., Negru A., Nelson D., Newcombe V., Nieboer D., Nyiradi J., Olubukola O., Oresic M., Ortolano F., Palotie A., Parizel P. M., Payen J. F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Pisica D., Ples H., Pomposo I., Posti J. P., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Retel Helmrich I., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roe C., Roise O., Rosand J., Rosenfeld J. V., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez Porras R., Sandor J., Schafer N., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stevens R., Stewart W., Stocchetti N., Sundstrom N., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Te Ao B., Tenovuo O., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Unterberg A., Vajkoczy P., Vallance S., Valeinis E., Vamos Z., van Der Jagt M., Van Der Steen G., van Der Naalt J., van Dijck J. T. J. M., van Essen T. A., Van Hecke W., van Heugten C., Van Praag D., van Veen E., Vande Vyvere T., van Wijk R. P. J., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K. W., Wiegers E., Williams G., Winzeck S., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F. A., Zelinkova V., Ziverte A., and Zoerle T.
- Abstract
After mild traumatic brain injury (mTBI), a substantial proportion of individuals do not fully recover on the Glasgow Outcome Scale Extended (GOSE) or experience persistent post-concussion symptoms (PPCS). We aimed to develop prognostic models for the GOSE and PPCS at 6 months after mTBI and to assess the prognostic value of different categories of predictors (clinical variables; questionnaires; computed tomography [CT]; blood biomarkers). From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, we included participants aged 16 or older with Glasgow Coma Score (GCS) 13-15. We used ordinal logistic regression to model the relationship between predictors and the GOSE, and linear regression to model the relationship between predictors and the Rivermead Post-concussion Symptoms Questionnaire (RPQ) total score. First, we studied a pre-specified Core model. Next, we extended the Core model with other clinical and sociodemographic variables available at presentation (Clinical model). The Clinical model was then extended with variables assessed before discharge from hospital: early post-concussion symptoms, CT variables, biomarkers, or all three categories (extended models). In a subset of patients mostly discharged home from the emergency department, the Clinical model was extended with 2-3–week post-concussion and mental health symptoms. Predictors were selected based on Akaike’s Information Criterion. Performance of ordinal models was expressed as a concordance index (C) and performance of linear models as proportion of variance explained (R2). Bootstrap validation was used to correct for optimism. We included 2376 mTBI patients with 6-month GOSE and 1605 patients with 6-month RPQ. The Core and Clinical models for GOSE showed moderate discrimination (C = 0.68 95% confidence interval 0.68 to 0.70 and C = 0.70[0.69 to 0.71], respectively) and injury severity was the strongest predictor. The extended models had better
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- 2023
172. The electronic specific heat of Ba1-xKxFe2As2 (x=0 to 1.0) from 2K to 380K
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Storey, J. G., Loram, J. W., Cooper, J. R., Bukowski, Z., and Karpinski, J.
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Condensed Matter - Superconductivity - Abstract
Using a high-resolution differential technique we have determined the electronic specific heat coefficient gamma(T) of Ba1-xKxFe2As2 with x=0 to 1.0, at temperatures (T) from 2K to 380K and in magnetic fields H=0 to 13T. In the normal state gamma_n(x,T) increases strongly with x at low temperature, compatible with a mass renormalisation ~12 at x=1, and decreases weakly with x at high temperature. A superconducting transition is seen in all samples from x=0.2 to 1, with transition temperatures and condensation energies peaking sharply at x=0.4. Superconducting coherence lengths xi_{ab}~20{\AA} and xi_c~3{\AA} are estimated from an analysis of Gaussian fluctuations. For many dopings we see features in the H and T-dependences of gamma_s(T,H) in the superconducting state that suggest superconducting gaps in three distinct bands. A broad "knee" and a sharp mean-field-like peak are typical of two coupled gaps. However, several samples show a shoulder above the sharp peak with an abrupt onset at T_{c,s} and a T-dependence gamma_s(T)\propto\sqrt{1-T/T_{c,s}}. We provide strong evidence that the shoulder is not due to doping inhomogeneity and suggest it is a distinct gap with an unconventional T-dependence Delta_s(T)\propto(1-T/T_{c,s})^{0.75} near T_{c,s}. We estimate band fractions and T=0 gaps from 3-band alpha-model fits to our data and compare the x-dependences of the band fractions with spectroscopic studies of the Fermi surface., Comment: 20 pages, 23 figures, published in Physical Review B
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- 2013
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173. Diamagnetism of YBa$_{2}$Cu$_{3}$O$_{6+x}$ crystals above $T_c$~: evidence for Gaussian fluctuations
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Kokanović, I., Hills, D. J., Sutherland, M. L., Liang, R., and Cooper, J. R.
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Condensed Matter - Superconductivity - Abstract
The magnetization of three high-quality single crystals of YBa$_{2}$Cu$_{3}$O$_{6+x}$, from slightly overdoped to heavily underdoped,has been measured using torque magnetometry. Striking effects in the angular dependence of the torque for the two underdoped crystals, a few degrees above the superconducting transition temperature ($T_c$) are described well by the theory of Gaussian superconducting fluctuations using a single adjustable parameter. The data at higher temperatures ($T$) are consistent with a strong cut-off in the fluctuations for $T\gtrsim1.1T_c$. Numerical estimates suggest that inelastic scattering could be responsible for this cut-off., Comment: 4 pages 3 Figures
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- 2013
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174. Carrying Capacity in Coastal Areas
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MacLeod, M., Cooper, J. Andrew G., Finkl, Charles W., Series Editor, Fairbridge, Rhodes W., Founding Editor, and Makowski, Christopher, editor
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- 2019
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175. Oral health status of children in rural schools in Kithoka, Kenya.
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Fujawa, D, Tyus, J, Cooper, J, Dzingle, J, Kapila, S, Eber, R, Gonzalez-Cabezas, C, Ndege, PK, Peck, M, Peck, S, and Kapila, Y
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Oral Health ,Dental Caries ,Periodontal Disease ,Fluorosis ,Pain ,Kenyan Children - Abstract
Background: Oral health studies to address dental needs of children have been conducted in Nairobi, Kenya. However, limited data is available for the rural areas of Kenya. The aim of this study was to gather baseline oral health data on primary school children in the rural Kithoka community of Meru, Kenya. Methods: A cross sectional dental examination and oral health survey of 583 children, aged 3-18 years, were performed. Decayed, missing, and filled primary/permanent teeth (dmft/DMFT) values were recorded. Gingival recession ranking, a gingival inflammation index, and a fluorosis index were also employed. Children were surveyed regarding dental visits, toothbrush ownership, and oral pain. Results: The average dmft/DMFT score was 1.2, fluorosis prevalence was 29%, gingival disease prevalence was 75.1%, oral pain prevalence was 29%, and 72% of children had never been to a dentist. Conclusions: DMFT scores for Kenyan children were almost exclusively comprised of decayed teeth. This finding probably reflects the low dentist-to-population ratio and the scarcity of dentists practicing in Kenyan rural areas. Gingival disease and pain prevalence in these children were high, exceeding those reported in developed countries. The findings reflect the oral health preventive and treatment needs for children in this Kenyan region.
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- 2014
176. Jovian plasma torus interaction with Europa. Plasma wake structure and effect of inductive magnetic field: 3D Hybrid kinetic simulation
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Lipatov, A. S., Cooper, J. F., Paterson, W. R., Sittler Jr., E. C., Hartle, R. E., and Simpson, D. G.
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Plasma Physics ,Physics - Space Physics - Abstract
The hybrid kinetic model supports comprehensive simulation of the interaction between different spatial and energetic elements of the Europa moon-magnetosphere system with respect a to variable upstream magnetic field and flux or density distributions of plasma and energetic ions, electrons, and neutral atoms. This capability is critical for improving the interpretation of the existing Europa flyby measurements from the Galileo Orbiter mission, and for planning flyby and orbital measurements (including the surface and atmospheric compositions) for future missions. The simulations are based on recent models of the atmosphere of Europa (Cassidy et al., 2007; Shematovich et al., 2005). In contrast to previous approaches with MHD simulations, the hybrid model allows us to fully take into account the finite gyroradius effect and electron pressure, and to correctly estimate the ion velocity distribution and the fluxes along the magnetic field (assuming an initial Maxwellian velocity distribution for upstream background ions). In this paper we discuss two tasks: (1) the plasma wake structure dependence on the parameters of the upstream plasma and Europa's atmosphere (model I, cases (a) and (b) with a homogeneous Jovian magnetosphere field, an inductive magnetic dipole and high oceanic shell conductivity); and (2) estimation of the possible effect of an induced magnetic field arising from oceanic shell conductivity. This effect was estimated based on the difference between the observed and modeled magnetic fields (model II, case (c) with an inhomogeneous Jovian magnetosphere field, an inductive magnetic dipole and low oceanic shell conductivity)., Comment: 36 pages, 13 figures, paper was submitted to Planetary and Space Science in Nov. 2011, special volume "Outer Planets" but still under review
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- 2012
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177. Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial
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Akın, S, Aladağ, N, Arif, A A, Aronne, L J, Aronoff, S, Ataoglu, E, Baik, S H, Bays, H, Beckett, P L, Berker, D, Bilz, S, Bode, B, Braun, E W, Buse, J B, Canani, L H S, Cho, Y M, Chung, C H, Colin, I, Condit, J, Cooper, J, Delgado, B, Eagerton, D C, El Ebrashy, I N, El Hefnawy, M H M F, Eliaschewitz, F G, Finneran, M P, Fischli, S, Fließer-Görzer, E, Geohas, J, Godbole, N A, Golay, A, Gorban de Lapertosa, S, Gross, J L, Gulseth, H L, Helland, F, Høivik, H O, Issa, C, Kang, E S, Keller, C, Khalil, S H A, Kim, N H, Kim, I J, Klaff, L J, Laimer, M, LaRocque, J C, Lederman, S N, Lee, K-W, Litchfield, W R, Manning, M B, Mertens, A, Morawski, E J, Murray, A V, Nicol, P R, O'Connor, T M, Oğuz, A, Ong, S, Özdemir, A, Palace, E M, Palchick, B A, Pereles-Ortiz, J, Pieber, T, Prager, R, Preumont, V, Riffer, E, Rista, L, Rudofsky, G, Sarı, R, Scheen, A, Schultes, B, Seo, J A, Shelbaya, S A, Sivalingam, K, Sorli, C H, Stäuble, S, Streja, D A, T'Sjoen, G, Tetiker, T, Van Gaal, L, Vercammen, C, Warren, M L, Weinstein, D L, Weiss, D, White, A, Winnie, M, Wium, C, Yavuz, D, Pieber, Thomas R, Bode, Bruce, Mertens, Ann, Cho, Young Min, Christiansen, Erik, Hertz, Christin L, Wallenstein, Signe O R, and Buse, John B
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- 2019
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178. Fundamental Physics at the Intensity Frontier
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Hewett, J. L., Weerts, H., Brock, R., Butler, J. N., Casey, B. C. K., Collar, J., de Gouvea, A., Essig, R., Grossman, Y., Haxton, W., Jaros, J. A., Jung, C. K., Lu, Z. T., Pitts, K., Ligeti, Z., Patterson, J. R., Ramsey-Musolf, M., Ritchie, J. L., Roodman, A., Scholberg, K., Wagner, C. E. M., Zeller, G. P., Aefsky, S., Afanasev, A., Agashe, K., Albright, C., Alonso, J., Ankenbrandt, C., Aoki, M., Arguelles, C. A., Arkani-Hamed, N., Armendariz, J. R., Armendariz-Picon, C., Diaz, E. Arrieta, Asaadi, J., Asner, D. M., Babu, K. S., Bailey, K., Baker, O., Balantekin, B., Baller, B., Bass, M., Batell, B., Beacham, J., Behr, J., Berger, N., Bergevin, M., Berman, E., Bernstein, R., Bevan, A. J., Bishai, M., Blanke, M., Blessing, S., Blondel, A., Blum, T., Bock, G., Bodek, A., Bonvicini, G., Bossi, F., Boyce, J., Breedon, R., Breidenbach, M., Brice, S. J., Briere, R. A., Brodsky, S., Bromberg, C., Bross, A., Browder, T. E., Bryman, D. A., Buckley, M., Burnstein, R., Caden, E., Campana, P., Carlini, R., Carosi, G., Castromonte, C., Cenci, R., Chakaberia, I., Chen, M. C., Cheng, C. H., Choudhary, B., Christ, N. H., Christensen, E., Christy, M. E., Chupp, T. E., Church, E., Cline, D. B., Coan, T. E., Coloma, P., Comfort, J., Coney, L., Cooper, J., Cooper, R. J., Cowan, R., Cowen, D. F., Cronin-Hennessy, D., Datta, A., Davies, G. S., Demarteau, M., DeMille, D. P., Denig, A., Dermisek, R., Deshpande, A., Dewey, M. S., Dharmapalan, R., Dhooghe, J., Dietrich, M. R., Diwan, M., Djurcic, Z., Dobbs, S., Duraisamy, M., Dutta, B., Duyang, H., Dwyer, D. A., Eads, M., Echenard, B., Elliott, S. R., Escobar, C., Fajans, J., Farooq, S., Faroughy, C., Fast, J. E., Feinberg, B., Felde, J., Feldman, G., Fierlinger, P., Perez, P. Fileviez, Filippone, B., Fisher, P., Flemming, B. T., Flood, K. T., Forty, R., Frank, M. J., Freyberger, A., Friedland, A., Gandhi, R., Ganezer, K. S., Garcia, A., Garcia, F. G., Gardner, S., Garrison, L., Gasparian, A., Geer, S., Gehman, V. M., Gershon, T., Gilchriese, M., Ginsberg, C., Gogoladze, I., Gonderinger, M., Goodman, M., Gould, H., Graham, M., Graham, P. W., Gran, R., Grange, J., Gratta, G., Green, J. P., Greenlee, H., Group, R. C., Guardincerri, E., Gudkov, V., Guenette, R., Haas, A., Hahn, A., Han, T., Handler, T., Hardy, J. C., Harnik, R., Harris, D. A., Harris, F. A., Harris, P. G., Hartnett, J., He, B., Heckel, B. R., Heeger, K. M., Henderson, S., Hertzog, D., Hill, R., Hinds, E. A, Hitlin, D. G., Holt, R. J., Holtkamp, N., Horton-Smith, G., Huber, P., Huelsnitz, W., Imber, J., Irastorza, I., Jaeckel, J., Jaegle, I., James, C., Jawahery, A., Jensen, D., Jessop, C. P., Jones, B., Jostlein, H., Junk, T., Kagan, A. L., Kalita, M., Kamyshkov, Y., Kaplan, D. M., Karagiorgi, G., Karle, A., Katori, T., Kayser, B., Kephart, R., Kettell, S., Kim, Y. K., Kirby, M., Kirch, K., Klein, J., Kneller, J., Kobach, A., Kohl, M., Kopp, J., Kordosky, M., Korsch, W., Kourbanis, I., Krisch, A. D., Krizan, P., Kronfeld, A. S., Kulkarni, S., Kumar, K. S., Kuno, Y., Kutter, T., Lachenmaier, T., Lamm, M., Lancaster, J., Lancaster, M., Lane, C., Lang, K., Langacker, P., Lazarevic, S., Le, T., Lee, K., Lesko, K. T., Li, Y., Lindgren, M., Lindner, A., Link, J., Lissauer, D., Littenberg, L. S., Littlejohn, B., Liu, C. Y., Loinaz, W., Lorenzon, W., Louis, W. C., Lozier, J., Ludovici, L., Lueking, L., Lunardini, C., MacFarlane, D. B., Machado, P. A. N., Mackenzie, P. B., Maloney, J., Marciano, W. J., Marsh, W., Marshak, M., Martin, J. W., Mauger, C., McFarland, K. S., McGrew, C., McLaughlin, G., McKeen, D., McKeown, R., Meadows, B. T., Mehdiyev, R., Melconian, D., Merkel, H., Messier, M., Miller, J. P., Mills, G., Minamisono, U. K., Mishra, S. R., Mocioiu, I., Sher, S. Moed, Mohapatra, R. N., Monreal, B., Moore, C. D., Morfin, J. G., Mousseau, J., Moustakas, L. A., Mueller, G., Mueller, P., Muether, M., Mumm, H. P., Munger, C., Murayama, H., Nath, P., Naviliat-Cuncin, O., Nelson, J. K., Neuffer, D., Nico, J. S., Norman, A., Nygren, D., Obayashi, Y., O'Connor, T. P., Okada, Y., Olsen, J., Orozco, L., Orrell, J. L., Osta, J., Pahlka, B., Paley, J., Papadimitriou, V., Papucci, M., Parke, S., Parker, R. H., Parsa, Z., Partyka, K., Patch, A., Pati, J. C., Patterson, R. B., Pavlovic, Z., Paz, G., Perdue, G. N., Perevalov, D., Perez, G., Petti, R., Pettus, W., Piepke, A., Pivovaroff, M., Plunkett, R., Polly, C. C., Pospelov, M., Povey, R., Prakesh, A., Purohit, M. V., Raby, S., Raaf, J. L., Rajendran, R., Rajendran, S., Rameika, G., Ramsey, R., Rashed, A., Ratcliff, B. N., Rebel, B., Redondo, J., Reimer, P., Reitzner, D., Ringer, F., Ringwald, A., Riordan, S., Roberts, B. L., Roberts, D. A., Robertson, R., Robicheaux, F., Rominsky, M., Roser, R., Rosner, J. L., Rott, C., Rubin, P., Saito, N., Sanchez, M., Sarkar, S., Schellman, H., Schmidt, B., Schmitt, M., Schmitz, D. W., Schneps, J., Schopper, A., Schuster, P., Schwartz, A. J., Schwarz, M., Seeman, J., Semertzidis, Y. K., Seth, K. K., Shafi, Q., Shanahan, P., Sharma, R., Sharpe, S. R., Shiozawa, M., Shiltsev, V., Sigurdson, K., Sikivie, P., Singh, J., Sivers, D., Skwarnicki, T., Smith, N., Sobczyk, J., Sobel, H., Soderberg, M., Song, Y. H., Soni, A., Souder, P., Sousa, A., Spitz, J., Stancari, M., Stavenga, G. C., Steffen, J. H., Stepanyan, S., Stoeckinger, D., Stone, S., Strait, J., Strassler, M., Sulai, I. A., Sundrum, R., Svoboda, R., Szczerbinska, B., Szelc, A., Takeuchi, T., Tanedo, P., Taneja, S., Tang, J., Tanner, D. B., Tayloe, R., Taylor, I., Thomas, J., Thorn, C., Tian, X., Tice, B. G., Tobar, M., Tolich, N., Toro, N., Towner, I. S., Tsai, Y., Tschirhart, R., Tunnell, C. D., Tzanov, M., Upadhye, A., Urheim, J., Vahsen, S., Vainshtein, A., Valencia, E., Van de Water, R. G., Van de Water, R. S., Velasco, M., Vogel, J., Vogel, P., Vogelsang, W., Wah, Y. W., Walker, D., Weiner, N., Weltman, A., Wendell, R., Wester, W., Wetstein, M., White, C., Whitehead, L., Whitmore, J., Widmann, E., Wiedemann, G., Wilkerson, J., Wilkinson, G., Wilson, P., Wilson, R. J., Winter, W., Wise, M. B., Wodin, J., Wojcicki, S., Wojtsekhowski, B., Wongjirad, T., Worcester, E., Wurtele, J., Xin, T., Xu, J., Yamanaka, T., Yamazaki, Y., Yavin, I., Yeck, J., Yeh, M., Yokoyama, M., Yoo, J., Young, A., Zimmerman, E., Zioutas, K., Zisman, M., Zupan, J., and Zwaska, R.
- Subjects
High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The Proceedings of the 2011 workshop on Fundamental Physics at the Intensity Frontier. Science opportunities at the intensity frontier are identified and described in the areas of heavy quarks, charged leptons, neutrinos, proton decay, new light weakly-coupled particles, and nucleons, nuclei, and atoms., Comment: 229 pages
- Published
- 2012
179. Comparative Effectiveness of a Second Tumor Necrosis Factor Inhibitor Versus a Non–Tumor Necrosis Factor Biologic in the Treatment of Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis
- Author
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Mannion, Melissa L., Amin, Shahla, Balevic, Stephen, Chang, Min‐Lee, Correll, Colleen K., Kearsley‐Fleet, Lianne, Hyrich, Kimme L., Beukelman, Timothy, Aamir, R., Abulaban, K., Adams, A., Aguiar Lapsia, C., Akinsete, A., Akoghlanian, S., Al Manaa, M., AlBijadi, A., Allenspach, E., Almutairi, A., Alperin, R., Amarilyo, G., Ambler, W., Amoruso, M., Angeles‐Han, S., Ardoin, S., Armendariz, S., Asfaw, L., Aviran Dagan, N., Bacha, C., Balboni, I., Balevic, S., Ballinger, S., Baluta, S., Barillas‐Arias, L., Basiaga, M., Baszis, K., Baxter, S., Becker, M., Begezda, A., Behrens, E., Beil, E., Benseler, S., Bermudez‐Santiago, L., Bernal, W., Bigley, T., Bingham, C., Binstadt, B., Black, C., Blackmon, B., Blakley, M., Bohnsack, J., Boneparth, A., Bradfield, H., Bridges, J., Brooks, E., Brothers, M., Brunner, H., Buckley, L., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Canna, S., Cannon, L., Canny, S., Cartwright, V., Cassidy, E., Castro, D., Chalom, E., Chang, J., Chang, M., Chang, J., Chang‐Hoftman, A., Chen, A., Chiraseveenuprapund, P., Ciaglia, K., Co, D., Cohen, E., Collinge, J., Conlon, H., Connor, R., Cook, K., Cooper, A., Cooper, J., Corbin, K., Correll, C., Cron, R., Curry, M., Dalrymple, A., Datyner, E., Davis, T., De Ranieri, D., Dean, J., DeCoste, C., Dedeoglu, F., DeGuzman, M., Delnay, N., DeSantis, E., Devine, R., Dhalla, M., Dhanrajani, A., Dissanayake, D., Dizon, B., Drapeau, N., Drew, J., Driest, K., Du, Q., Duncan, E., Dunnock, K., Durkee, D., Dvergsten, J., Eberhard, A., Ede, K., Edelheit, B., Edens, C., El Tal, T., Elder, M., Elzaki, Y., Fadrhonc, S., Failing, C., Fair, D., Favier, L., Feldman, B., Fennell, J., Ferguson, P., Ferguson, I., Figueroa, C., Flanagan, E., Fogel, L., Fox, E., Fox, M., Franklin, L., Fuhlbrigge, R., Fuller, J., Furey, M., Futch‐West, T., Gagne, S., Gennaro, V., Gerstbacher, D., Gilbert, M., Gironella, A., Glaser, D., Goh, I., Goldsmith, D., Gorry, S., Goswami, N., Gottlieb, B., Graham, T., Grevich, S., Griffin, T., Grim, A., Grom, A., Guevara, M., Hahn, T., Halyabar, O., Hamda Natur, M., Hammelev, E., Hammond, T., Harel, L., Harris, J., Harry, O., Hausmann, J., Hay, A., Hays, K., Hayward, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horton, D., Horwitz, M., Hsu, J., Huber, A., Huberts, A., Huggins, J., Huie, L., Hui‐Yuen, J., Ibarra, M., Imlay, A., Imundo, L., Inman, C., Jackson, A., James, K., Janow, G., Jared, S., Jiang, Y., Johnson, L., Johnson, N., Jones, J., Kafisheh, D., Kahn, P., Kaidar, K., Kasinathan, S., Kaur, R., Kessler, E., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Knight, A., Kovalick, L., Kramer, S., Kremer, C., Kudas, O., LaFlam, T., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Lawler, C., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lee, A., Leisinger, E., Lentini, L., Lerman, M., Levinsky, Y., Levy, D., Li, S., Lieberman, S., Lim, L., Limenis, E., Lin, C., Ling, N., Lionetti, G., Livny, R., Lloyd, M., Lo, M., Long, A., Lopez‐Peña, M., Lovell, D., Luca, N., Lvovich, S., Lytch, A., Ma, M., Machado, A., MacMahon, J., Madison, J., Mannion, M., Manos, C., Mansfield, L., Marston, B., Mason, T., Matchett, D., McAllister, L., McBrearty, K., McColl, J., McCurdy, D., McDaniels, K., McDonald, J., Meidan, E., Mellins, E., Mian, Z., Miettunen, P., Miller, M., Milojevic, D., Mitacek, R., Modica, R., Mohan, S., Moore, T., Moore, K., Moorthy, L., Moreno, J., Morgan, E., Moyer, A., Murante, B., Murphy, A., Muscal, E., Mwizerwa, O., Najafi, A., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Nearanz, K., Neely, J., Newhall, L., Nguyen, A., Nigrovic, P., Nocton, J., Nolan, B., Nowicki, K., Oakes, R., Oberle, E., Ogbonnaya‐Whittesley, S., Ogbu, E., Oliver, M., Olveda, R., Onel, K., Orandi, A., Padam, J., Paller, A., Pan, N., Pandya, J., Panupattanapong, S., Toledano, A. Pappo, Parsons, A., Patel, J., Patel, P., Patrick, A., Patrizi, S., Paul, S., Perfetto, J., Perron, M., Peskin, M., Ponder, L., Pooni, R., Prahalad, S., Puplava, B., Quinlan‐Waters, M., Rabinovich, C., Rafko, J., Rahimi, H., Rampone, K., Ramsey, S., Randell, R., Ray, L., Reed, A., Reed, A., Reid, H., Reiff, D., Richins, S., Riebschleger, M., Rife, E., Riordan, M., Riskalla, M., Robinson, A., Robinson, L., Rodgers, L., Rodriquez, M., Rogers, D., Ronis, T., Rosado, A., Rosenkranz, M., Rosenwasser, N., Rothermel, H., Rothman, D., Rothschild, E., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Rupp, J., Ruth, N., Sabbagh, S., Sadun, R., Santiago, L., Saper, V., Sarkissian, A., Scalzi, L., Schahn, J., Schikler, K., Schlefman, A., Schmeling, H., Schmitt, E., Schneider, R., Schulert, G., Schultz, K., Schutt, C., Seper, C., Sheets, R., Shehab, A., Shenoi, S., Sherman, M., Shirley, J., Shishov, M., Siegel, D., Singer, N., Sivaraman, V., Sloan, E., Smith, C., Smith, J., Smitherman, E., Soep, J., Son, Mary B., Sosna, D., Spencer, C., Spiegel, L., Spitznagle, J., Srinivasalu, H., Stapp, H., Steigerwald, K., Stephens, A., Sterba Rakovchik, Y., Stern, S., Stevens, B., Stevenson, R., Stewart, K., Stewart, W., Stingl, C., Stoll, M., Stringer, E., Sule, S., Sullivan, J., Sundel, R., Sutter, M., Swaffar, C., Swayne, N., Syed, R., Symington, T., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Tesher, M., Thakurdeen, T., Theisen, A., Thomas, B., Thomas, L., Thomas, N., Ting, T., Todd, C., Toib, D., Toib, D., Torok, K., Tory, H., Toth, M., Tse, S., Tsin, C., Twachtman‐Bassett, J., Twilt, M., Valcarcel, T., Valdovinos, R., Vallee, A., Van Mater, H., Vandenbergen, S., Vannoy, L., Varghese, C., Vasquez, N., Vega‐Fernandez, P., Velez, J., Verbsky, J., Verstegen, R., Scheven, E., Vora, S., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, B., Walters, H., Waterfield, M., Waters, A., Weiser, P., Weiss, P., Weiss, J., Wershba, E., Westheuser, V., White, A., Widrick, K., Williams, C., Wong, S., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yasin, S., Yeung, R., Yomogida, K., Zeft, A., Zhang, Y., Zhao, Y., and Zhu, A.
- Abstract
The objective of this study was to compare the effectiveness of a second tumor necrosis factor inhibitor (TNFi) versus a non‐TNFi biologic following discontinuation of a TNFi for patients with polyarticular‐course juvenile idiopathic arthritis (pJIA). Using the Childhood Arthritis and Rheumatology Research Alliance Registry, patients with pJIA who started receiving a second biologic following a first TNFi were identified. Patients were required to have no active uveitis on the index date and a visit six months after the index date. Outcome measures included Clinical Juvenile Arthritis Disease Activity Score with a maximum of 10 active joints (cJADAS10), cJADAS10 inactive disease (ID; ≤2.5) and cJADAS10 minimal disease activity (MiDA; ≤5). Multiple imputation was used to account for missing data. Adjusted odds ratios (aORs) were calculated using propensity score quintiles to compare outcomes at six months following second biologic initiation. There were 216 patients included, 84% initially received etanercept, and most patients stopped receiving it because of its ineffectiveness (74%). A total of 183 (85%) started receiving a second TNFi, and 33 (15%) started receiving a non‐TNFi. Adalimumab was the most common second biologic received (71% overall, 84% of second TNFi), and tocilizumab was the most common non‐TNFi second biologic received (9% overall, 58% of non‐TNFi). There was no difference between receiving TNFi versus non‐TNFi in cJADAS10 ID (29% vs 25%; aOR 1.23, 95% confidence interval [CI] 0.47–3.20) or at least MiDA (43% vs 39%; aOR 1.11, 95% CI 0.47–2.62) at six months. Most patients with pJIA started receiving TNFi rather than non‐TNFi as their second biologic, and there were no differences in disease activity at six months.
- Published
- 2024
- Full Text
- View/download PDF
180. SUMMER TOP 100.
- Author
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Cooper, J. J., Yamada, Austin, Eddy, Matt, and Norris, Josh
- Published
- 2024
181. CHARLIE MUSCLE.
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COOPER, J. J. and Eddy, Matt
- Published
- 2024
182. WHAT A DIFFERENCE A YEAR MAKES.
- Author
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Cooper, J. J.
- Published
- 2024
183. Down Syndrome–Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes
- Author
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Jones, Jordan T., Smith, Chelsey, Becker, Mara L., Lovell, Daniel, Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Akoghlanian, S., Al Ahmed, O., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Anastasopoulos, D., Anderson, E., Andrew, M., Ardalan, K., Ardoin, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Birmingham, J., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Brooks, E., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullington, A., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carpenter, S., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chiu, Y., Chundru, K., Clairman, H., Co, D., Collins, K., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Cospito, T., Costanzo, D., Cron, R., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Dionizovik‐Dimanovski, M., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Drummond, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edens, C., Edens, C., Edgerly, Y., Elder, M., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Feldman, B., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleck, D., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gergely, T., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Goh, I., Goldberg, T., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Guevara, M., Guittar, P., Gurion, R., Guzman, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hansman, E., Hanson, A., Harel, L., Haro, S., Harris, J., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hughes, R., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Iqbal, S., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Kahn, P., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khaleel, M., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lang, B., Lapidus, S., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Luca, N., Lvovich, S., Ma, M., Mackey, C., Madison, C., Madison, J., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCallum, B., McCarthy, K., McConnell, K., McCurdy, D., McCurdy Stokes, P., McGuire, S., McHale, I., McHugh, A., McKibben, K., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Morgan Dewitt, E., Morris, S., Moss, C., Moussa, T., Mruk, V., Mulvhihill, E., Muscal, E., Nahal, B., Nanda, K., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nguyen, E., Nicholas, J., Nigrovic, P., Nocton, J., Oberle, E., Obispo, B., O’Brien, B., O’Brien, T., O’Connor, M., Oliver, M., Olson, J., O’Neil, K., Onel, K., Orlando, M., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Punaro, M., Puplava, B., Quach, J., Quinlan‐Waters, M., Quintero, A., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramsay, E., Ramsey, S., Reed, A., Reed, A., Reed, A., Reid, H., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Roberson, S., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosenwasser Raines, N., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster–Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabatino, M., Sabbagh, S., Sadun, R., Sandborg, C., Sanni, A., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shen, B., Shenoi, S., Shergill, K., Shiff, N., Shirley, J., Shishov, M., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Snider, C., Soep, J., Son, M., Soybilgic, A., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Stasek, J., Steigerwald, K., Sterba Rakovchik, Y., Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stoops, S., Strelow, J., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sura, A., Sutter, M., Syed, R., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Treemarcki, E., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vega‐Fernandes, P., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Wampler Muskardin, T., Wang, C., Waqar, L., Waterfield, M., Watson, M., Watts, A., Waugaman, B., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zemel, L., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
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- 2021
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184. Thermodynamical identities---a systematic approach
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Cooper, J. B.
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Mathematical Physics - Abstract
We present a systematic approach to thermodynamical identities and illustrate the power of these methods by displaying Mathematica notebooks to deal with a large variety of such identities. In concrete examples these can involve rather tedious, not to way impossible, computations when done by hand., Comment: arXiv admin note: substantial text overlap with arXiv:1102.1540
- Published
- 2011
185. Evidence for Dirac Nodes from Quantum Oscillations in SrFe$_2$As$_2$
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Sutherland, Mike, Hills, D. J., Tan, B. S., Altarawneh, M. M., Harrison, N., Gillett, J., O'Farrell, E. C. T., Benseman, T. M., Kokanovic, I., Syers, P., Cooper, J. R., and Sebastian, Suchitra E.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We present a detailed study of quantum oscillations in the antiferromagnetically ordered pnictide compound SrFe$_2$As$_2$ as the angle between the applied magnetic field and crystalline axes is varied. Our measurements were performed on high quality single crystals in a superconducting magnet, and in pulsed magnetic fields up to 60 T, allowing us to observe orbits from several small Fermi surface pockets. We extract the cyclotron effective mass $m^{\star}$ and frequency $F$ for these orbits and track their values as the field is rotated away from the c-axis. While a constant ratio of $m^{\star}/F$ is observed for one orbit as expected for a parabolic band, a clear deviation is observed for another. We conclude that this deviation points to an orbit derived from a band with Dirac dispersion near the Fermi level., Comment: 5 pages, 4 figures
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- 2011
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186. Thickness-dependent magnetic properties of oxygen-deficient EuO
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Barbagallo, M., Stollenwerk, T., Kroha, J., Steinke, N. -J., Hine, N. D. M., Cooper, J. F. K., Barnes, C. H. W., Ionescu, A., Monteiro, P. M. D. S., Kim, J. -Y., Ziebeck, K. R. A., Kinane, C. J., Dalgliesh, R. M., Charlton, T. R., and Langridge, S.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We have studied how the magnetic properties of oxygen-deficient EuO sputtered thin films vary as a function of thickness. The magnetic moment, measured by polarized neutron reflectometry, and the Curie temperature are found to decrease with reducing thickness. Our results indicate that the reduced number of nearest neighbors, band bending and the partial depopulation of the electronic states that carry the spins associated with the 4f orbitals of Eu are all contributing factors in the surface-induced change of the magnetic properties of EuO$_{1-x}$., Comment: 4 pages, 3 figures, 1 table
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- 2011
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187. On the Mathematics of Thermodynamics
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Cooper, J. B. and Russell, T.
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Mathematical Physics - Abstract
We show that the mathematical structure of Gibbsian thermodynamics flows from the following simple elements: the state space of a thermodynamical substance is a measure space together with two orderings (corresponding to "warmer than" and "adiabatically accessible from") which satisfy certain plausible physical axioms and an area condition which was introduced by Paul Samuelson. We show how the basic identities of thermodynamics, in particular the Maxwell relations, follow and so the existence of energy, free energy, enthalpy and the Gibbs potential function. We also discuss some questions which we have not found dealt with in the literature, such as the amount of information required to reconstruct the equations of state of a substance and a systematic approach to thermodynamical identities.
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- 2011
188. Quantum metrology with rotating matter waves in different geometries
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Dunningham, J. A., Cooper, J. J., and Hallwood, D. W.
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Quantum Physics - Abstract
A promising practical application of entanglement is metrology, where quantum states can be used to make measurements beyond the shot noise limit. Here we consider how metrology schemes could be realised using atomic Bose-Einstein condensates (BECs) trapped in different potentials. In particular, we show that if a trapped BEC is rotated at just the right frequency, it can undergo a quantum phase transition characterised by large-scale entanglement spreading across the system. This simple process of stirring can generate interesting quantum states such as macroscopic superpositions of all the atoms flowing in opposite directions around a ring-shaped potential. We consider different trapping potentials and show how this leads to different entangled states. In particular, we find that by reducing the dimensionality of the system to one or two dimensions, it is possible to generate entangled states that are remarkably robust to the loss of atoms and so are ideally suited to precision measurement schemes., Comment: 12 pages, 5 figures
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- 2011
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189. Robust quantum enhanced phase estimation in a multimode interferometer
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Cooper, J. J., Hallwood, D. W., Dunningham, J. A., and Brand, J.
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Quantum Physics ,Condensed Matter - Quantum Gases - Abstract
By exploiting the correlation properties of ultracold atoms in a multi-mode interferometer, we show how quantum enhanced measurement precision can be achieved with strong robustness to particle loss. While the potential for enhanced measurement precision is limited for even moderate loss in two-mode schemes, multi-mode schemes can be more robust. A ring interferometer for sensing rotational motion with non-interacting fermionic atoms can realize an uncertainty scaling of $1/(N\sqrt{\eta})$ for $N$ particles with a fraction $\eta$ remaining after loss, which undercuts the shot noise limit of two mode interferometers. A second scheme with strongly-interacting bosons achieves a comparable measurement precision and improved readout., Comment: 5 pages, 2 figures, replaced by final version
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- 2011
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190. Open quantum systems approach to atomtronics
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Pepino, R. A., Cooper, J., Meiser, D., Anderson, D. Z., and Holland, M. J.
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Quantum Physics ,Physics - Atomic Physics - Abstract
We derive a quantum master equation to treat quantum systems interacting with multiple reservoirs. The formalism is used to investigate atomic transport across a variety of lattice configurations. We demonstrate how the behavior of an electronic diode, a field-effect transistor, and a bipolar junction transistor can be realized with neutral, ultracold atoms trapped in optical lattices. An analysis of the current fluctuations is provided for the case of the atomtronic diode. Finally, we show that it is possible to demonstrate AND logic gate behavior in an optical lattice., Comment: 10 pages, 10 figures, 1 table
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- 2010
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191. Fermiology and electronic homogeneity of the superconducting overdoped cuprate Tl-2201 revealed by quantum oscillations
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Bangura, A. F., Rourke, P. M. C., Benseman, T. M., Matusiak, M., Cooper, J. R., Hussey, N. E., and Carrington, A.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We report an angular quantum oscillation study of Tl_2Ba_2CuO_{6+delta} for two different doping levels (Tc = 10K and 26 K) and determine the Fermi surface size and topology in considerable detail. Our results show that Fermi liquid behavior is not confined to the edge of the superconducting dome and is robust up to at least T_c^{max}/3.5. Superconductivity is found to survive up to a larger doping p_c = 0.31 than in La_{2-x}Sr_xCuO_4. Our data imply that electronic inhomogeneity does not play a significant role in the loss of superconductivity and superfluid density in overdoped cuprates, and point towards a purely magnetic or electronic pairing mechanism, Comment: 4 pages
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- 2010
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192. Entanglement enhanced atomic gyroscope
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Cooper, J. J., Hallwood, D. W., and Dunningham, J. A.
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Quantum Physics - Abstract
The advent of increasingly precise gyroscopes has played a key role in the technological development of navigation systems. Ring-laser and fibre-optic gyroscopes, for example, are widely used in modern inertial guidance systems and rely on the interference of unentangled photons to measure mechanical rotation. The sensitivity of these devices scales with the number of particles used as $1/ \sqrt{N}$. Here we demonstrate how, by using sources of entangled particles, it is possible to do better and even achieve the ultimate limit allowed by quantum mechanics where the precision scales as 1/N. We propose a gyroscope scheme that uses ultra-cold atoms trapped in an optical ring potential., Comment: 19 pages, 2 figures
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- 2010
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193. Equivalence of the generalized and complex Kohn variational methods
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Cooper, J. N., Plummer, M., and Armour, E. A. G.
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Quantum Physics ,Mathematical Physics - Abstract
For Kohn variational calculations on low energy positron hydrogen molecule elastic scattering, we prove that the phase shift approximation obtained using the complex Kohn method is precisely equal to a value which can be obtained immediately via the real-generalized Kohn method. Our treatment is sufficiently general to be applied directly to arbitrary potential scattering or single open channel scattering problems, with exchange if required. In the course of our analysis, we develop a framework formally to describe the anomalous behaviour of our generalized Kohn calculations in the regions of the well known Schwartz singularities. This framework also explains the mathematical origin of the anomaly-free singularities we reported in a previous article. Moreover, we demonstrate a novelty, that explicit solutions of the Kohn equations are not required in order to calculate optimal phase shift approximations. We relate our rigorous framework to earlier descriptions of the Kohn-type methods., Comment: 33 pages, no figures. This version of the article has been accepted by J. Phys. A.
- Published
- 2010
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194. The electronic specific heat of Ba1-xKxFe2As2 from 2K to 380K
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Storey, J. G., Loram, J. W., Cooper, J. R., Bukowski, Z., and Karpinski, J.
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Condensed Matter - Superconductivity - Abstract
Using a differential technique, we have measured the specific heats of polycrystalline Ba1-xKxFe2As2 samples with x=0, 0.1 and 0.3, between 2K and 380K and in magnetic fields 0 to 13 Tesla. From this data we have determined the electronic specific heat coefficient, gamma, over the entire range for the three samples. The most heavily doped sample (x=0.3) exhibits a large superconducting anomaly Delta gamma(Tc)~48mJ/molK^2 at Tc=35K, and we determine the energy gap, condensation energy, superfluid density and coherence length. In the normal state for the x=0.3 sample, gamma~47 mJ/molK^2 is constant from Tc to 380K. In the parent compound (x=0) there is a large almost first order anomaly at the spin density wave (SDW) transition at To=136K. This anomaly is smaller and broader for x=0.1. At low T, gamma is strongly reduced by the SDW gap for both x=0 and 0.1, but above To, gamma for all three samples are similar., Comment: 5 pages, 5 figures, submitted to Physical Review B
- Published
- 2010
195. Measurement and analysis of the Hall effect of A-Fe$_2$As$_2$ single crystals with A = Ba, Ca or Sr
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Zentile, C. L., Gillett, J., Sebastian, S. E., and Cooper, J. R.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We report measurements of the Hall coefficient $R_H$ for single crystals of AFe$_2$As$_2$ with $A = Ba, Ca$ or $Sr$ which are the anti-ferromagnetic parent compounds of some high temperature pnictide superconductors. We show that $R_H$ of Sr-122 is consistent with high field quantum oscillation data. Our $R_H(T)$ data can also be used to estimate values of the spin density wave gap, giving $\Delta_{SDW}(0) = 710\pm 70$ K for Sr-122 and $435\pm 20$ K for Ba-122., Comment: 5 pages, 4 figures, 1 table
- Published
- 2009
196. Evidence for a charge Kondo effect in Pb(1-x)Tl(x)Te from measurements of thermoelectric power
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Matusiak, M., Tunnicliffe, E. M., Cooper, J. R., Matsushita, Y., and Fisher, I. R.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We report measurements of the thermoelectric power (TEP) for a series of Pb(1-x)Tl(x)Te crystals with x = 0.0 to 1.3%. Although the TEP is very large for x = 0.0, using a single band analysis based on older work for dilute magnetic alloys we do find evidence for a Kondo contribution of 11 - 18 uV/K. This analysis suggests that Tk is ~ 50 - 70 K, a factor 10 higher than previously thought., Comment: 4 pages, 3 figures
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- 2009
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197. Starburst-Driven Galactic Winds: Filament Formation and Emission Processes
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Cooper, J. L., Bicknell, G. V., Sutherland, R. S., and Bland-Hawthorn, J.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We have performed a series of three-dimensional simulations of the interaction of a supersonic wind with a non-spherical radiative cloud. These simulations are motivated by our recent three-dimensional model of a starburst-driven galactic wind interacting with an inhomogeneous disk, which show that an optically emitting filament can be formed by the break-up and acceleration of a cloud into a supersonic wind. In this study we consider the evolution of a cloud with two different geometries (fractal and spherical) and investigate the importance of radiative cooling on the cloud's survival. We have also undertaken a comprehensive resolution study in order to ascertain the effect of the assumed numerical resolution on the results. We find that the ability of the cloud to radiate heat is crucial for its survival. While an adiabatic cloud is destroyed over a short period of time, a radiative cloud is broken up via the Kelvin-Helmholtz instability into numerous small, dense cloudlets, which are drawn into the flow to form a filamentary structure. The degree of fragmentation is highly dependent on the resolution of the simulation, with the number of cloudlets formed increasing as the Kelvin-Helmholtz instability is better resolved. Nevertheless, there is a clear qualitative trend, with the filamentary structure still persistent at high resolution. We confirm the mechanism behind the formation of the H-alpha emitting filaments found in our global simulations of a starburst-driven wind. Based on our resolution study, we conclude that bow shocks around accelerated gas clouds, and their interaction, are the main source of the soft X-ray emission observed in these galactic-scale winds. [ABRIDGED], Comment: Accepted to ApJ, 39 pages, 21 figures, movie file can obtained at http://www.mso.anu.edu.au/~jcooper/movie/halpha.mov
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- 2009
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198. Effect of hole doping on the London penetration depth of Bi:2212 and Bi(Y):2212
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Anukool, W., Barakat, S., Panagopoulos, C., and Cooper, J. R.
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Condensed Matter - Superconductivity - Abstract
We report measurements of AC susceptibility and hence the in-plane London penetration depth on the same samples of Bi:2212 and Bi(Y):2212 for many values of the planar hole concentration/CuO2 unit (p). These support the scenario in which the pseudogap weakens the superconducting response only for p less than approximately 0.19., Comment: 5 journal pages 4 figures
- Published
- 2009
199. Influence of the pseudogap on the Nernst coefficient of Y0.9Ca0.1Ba2Cu3Oy
- Author
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Matusiak, M., Naqib, S. H., Kokanovic', I., and Cooper, J. R.
- Subjects
Condensed Matter - Superconductivity - Abstract
We have studied the Nernst coefficient, v(T), of epitaxial thin films of the superconductor Y1-xCaxBa2Cu3Oy with x =0.05 and x = 0.1. The x = 0.1 sample has been measured at three different values of y, in the over- (OV), optimally- (OP), and under-doped (UD) states. As the doping level is reduced, v(T) starts to fall linearly with T at the temperature (T*) where we expect to see the influence of the pseudogap. The onset temperature of the superconducting fluctuation contribution to v(T) was found to vary slowly with the hole concentration (p) between p = 0.118 and 0.197. For the OP and UD samples, v(T>T*) is unusually large, being comparable with |S tan(Theta)| where S is the Seebeck coefficient and Theta the Hall angle., Comment: 13 pages, 4 figures
- Published
- 2009
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200. Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD
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Criner, Gerard J, Connett, John E, Aaron, Shawn D, Albert, Richard K, Bailey, William C, Casaburi, Richard, Cooper, J Allen D, Curtis, Jeffrey L, Dransfield, Mark T, Han, MeiLan K, Make, Barry, Marchetti, Nathaniel, Martinez, Fernando J, Niewoehner, Dennis E, Scanlon, Paul D, Sciurba, Frank C, Scharf, Steven M, Sin, Don D, Voelker, Helen, Washko, George R, Woodruff, Prescott G, and Lazarus, Stephen C
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Chronic Obstructive Pulmonary Disease ,Prevention ,Clinical Research ,Lung ,Clinical Trials and Supportive Activities ,Cardiovascular ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Respiratory ,Good Health and Well Being ,Adult ,Aged ,Female ,Forced Expiratory Volume ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Lipids ,Male ,Middle Aged ,Prospective Studies ,Pulmonary Disease ,Chronic Obstructive ,Quality of Life ,Severity of Illness Index ,Simvastatin ,Treatment Failure ,Vital Capacity ,COPD Clinical Research Network ,Canadian Institutes of Health Research ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundRetrospective studies have shown that statins decrease the rate and severity of exacerbations, the rate of hospitalization, and mortality in chronic obstructive pulmonary disease (COPD). We prospectively studied the efficacy of simvastatin in preventing exacerbations in a large, multicenter, randomized trial.MethodsWe designed the Prospective Randomized Placebo-Controlled Trial of Simvastatin in the Prevention of COPD Exacerbations (STATCOPE) as a randomized, controlled trial of simvastatin (at a daily dose of 40 mg) versus placebo, with annual exacerbation rates as the primary outcome. Patients were eligible if they were 40 to 80 years of age, had COPD (defined by a forced expiratory volume in 1 second [FEV1] of less than 80% and a ratio of FEV1 to forced vital capacity of less than 70%), and had a smoking history of 10 or more pack-years, were receiving supplemental oxygen or treatment with glucocorticoids or antibiotic agents, or had had an emergency department visit or hospitalization for COPD within the past year. Patients with diabetes or cardiovascular disease and those who were taking statins or who required statins on the basis of Adult Treatment Panel III criteria were excluded. Participants were treated from 12 to 36 months at 45 centers.ResultsA total of 885 participants with COPD were enrolled for approximately 641 days; 44% of the patients were women. The patients had a mean (±SD) age of 62.2±8.4 years, an FEV1 that was 41.6±17.7% of the predicted value, and a smoking history of 50.6±27.4 pack-years. At the time of study closeout, the low-density lipoprotein cholesterol levels were lower in the simvastatin-treated patients than in those who received placebo. The mean number of exacerbations per person-year was similar in the simvastatin and placebo groups: 1.36±1.61 exacerbations and 1.39±1.73 exacerbations, respectively (P=0.54). The median number of days to the first exacerbation was also similar: 223 days (95% confidence interval [CI], 195 to 275) and 231 days (95% CI, 193 to 303), respectively (P=0.34). The number of nonfatal serious adverse events per person-year was similar, as well: 0.63 events with simvastatin and 0.62 events with placebo. There were 30 deaths in the placebo group and 28 in the simvastatin group (P=0.89).ConclusionsSimvastatin at a daily dose of 40 mg did not affect exacerbation rates or the time to a first exacerbation in patients with COPD who were at high risk for exacerbations. (Funded by the National Heart, Lung, and Blood Institute and the Canadian Institutes of Health Research; STATCOPE ClinicalTrials.gov number, NCT01061671.).
- Published
- 2014
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