1,250 results on '"Cookson, Mark R."'
Search Results
152. The biochemistry of Parkinson's disease
153. Parkin’s substrates and the pathways leading to neuronal damage
154. Assays for Pten-Induced Novel Kinase 1 (PINK1) and Leucine-Rich Repeat Kinase 2 (LRRK2), Kinases Associated with Parkinson’s Disease
155. Lysosomal impairment in Parkinsonʼs disease
156. The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinsonʼs disease with a sexual dimorphism
157. Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies
158. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinsonʼs disease
159. Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci
160. Unravelling the role of defective genes
161. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
162. Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system
163. MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies
164. The Role of LRRK2 Kinase Activity in Cellular PD Models
165. Astrocytes in Parkinsonʼs disease and DJ-1
166. Distinct DNA methylation changes highly correlated with chronological age in the human brain
167. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
168. Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
169. LRRK2 mediates tubulation and vesicle sorting from lysosomes
170. Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
171. LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
172. Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
173. THAP1 Modulates Oligodendrocyte Maturation by Regulating ECM Degradation in Lysosomes
174. Preclinical Modeling of Chronic Inhibition of the Parkinson’s Disease Associated Kinase LRRK2 Reveals Altered Function of the Endolysosomal System in Vivo
175. Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
176. Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
177. Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo
178. LRRK2-mediated microglial activation via NFATc2: a novel mechanism of neurotoxic inflammation in synucleinopathies
179. Can Leucine‐Rich Repeat Kinase 2 Inhibition Benefit GBA –Parkinson's Disease?
180. The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
181. Common variation at the LRRK2 locus is associated with survival in the primary tauopathy progressive supranuclear palsy
182. LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes
183. Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at Chr16q11.2 and on the MAPT H1 allele
184. Loss of LrrK2 Function Potentiates Dopamine Signaling in the Striatum to Promote Compulsive Alcohol Use
185. Parkinsonʼs disease: insights from pathways
186. Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α-synuclein, and tau
187. MKK6 binds and regulates expression of Parkinsonʼs disease-related protein LRRK2
188. DJ-1, PINK1, and their effects on mitochondrial pathways
189. Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling
190. Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
191. Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.
192. Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modeling
193. Emerging pathways in genetic Parkinsonʼs disease: Potential role of ceramide metabolism in Lewy body disease
194. The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight
195. Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa
196. Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
197. Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1
198. Hero versus antihero: The multiple roles of α-synuclein in neurodegeneration
199. Variation in tau isoform expression in different brain regions and disease states
200. Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinsonʼs disease
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