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Your search keyword '"Codecasa, Luigi"' showing total 153 results
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153 results on '"Codecasa, Luigi"'

151. Use of T-SPOT.TB in latent tuberculosis infection diagnosis in general and immunosuppressed populations.

Author

Piana F, Ruffo Codecasa L, Baldan R, Miotto P, Ferrarese M, and Cirillo DM

Subjects
Bacterial Proteins immunology, Bacterial Proteins metabolism, Hematologic Diseases immunology, Humans, Interferon-gamma biosynthesis, Interferon-gamma immunology, Logistic Models, Mycobacterium tuberculosis metabolism, Peptides immunology, Sensitivity and Specificity, Species Specificity, T-Lymphocytes immunology, Bacteriological Techniques, Carrier State diagnosis, Immunocompetence, Immunocompromised Host, Reagent Kits, Diagnostic, Tuberculosis diagnosis
Abstract

Immunosuppressed patients have a nine-fold greater risk of developing active tuberculosis (TB) disease given the latent TB infection than the general population. Few data are available on the predictivity of T-SPOT.TB in immunosuppressed patients. We had a T-SPOT.TB determination and a TST from 197 immunosuppressed haematological patients and 324 community contacts of infectious TB cases. In the general population, TST was positive in 275 (84.9%), T-SPOT.TB in 167 (51.5%) (p < 0.0001). In immunosuppressed patients, TST was positive in 34 (17.3%), T-SPOT.TB in 70 (35.5%). T-SPOT.TB is not influenced by immunosuppression and even an indeterminate result may yield useful information on patient's anergy.

Published
2007

152. Comparison of a commercial and an in-house T cell-based assay for the diagnosis of Mycobacterium tuberculosis infection.

Author

Mantegani P, Piana F, Galli L, Scarpellini P, Codecasa L, Lazzarin A, Cirillo D, and Fortis C

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Proteins immunology, Child, Child, Preschool, Female, Humans, Infant, Interferon-gamma biosynthesis, Male, Middle Aged, Peptides chemical synthesis, Peptides immunology, Sensitivity and Specificity, T-Lymphocytes immunology, Tuberculosis blood, Immunoenzyme Techniques methods, Mycobacterium tuberculosis metabolism, Reagent Kits, Diagnostic, Tuberculosis diagnosis
Abstract

Identification of individuals with a tuberculosis infection is a very important element for the control of tuberculosis. The currently used tuberculin skin test has poor sensitivity and specificity. Recently, an important advance in tuberculosis diagnosis occurred with the development of in vitro T cell-based IFN-gamma release assays. The aim of this study was to compare a RD1-based in-house ELISPOT-IFN-gamma assay with a commercial (T-SPOT.TB) assay for the diagnosis of tuberculosis infection. The results showed an almost complete concordance between the two assays, confirming that our restricted but highly selected pool of peptides is sufficient to detect tuberculosis infection.

Published
2007

153. [BCG vaccination against tuberculosis in the health system].

Author

Bugiani M, Besozzi G, Codecasa L, Migliori GB, and Fiorentini F

Subjects
Cross Infection prevention & control, Guidelines as Topic, Humans, Infectious Disease Transmission, Patient-to-Professional prevention & control, Infectious Disease Transmission, Professional-to-Patient prevention & control, Italy, Occupational Diseases prevention & control, Risk, Tuberculosis transmission, Tuberculosis, Multidrug-Resistant prevention & control, BCG Vaccine, Health Personnel, Tuberculosis prevention & control, Vaccination legislation & jurisprudence
Published
2005

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