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153. Contributors

Author

Abbruzzese, James L., primary, Abdel-Wahab, Omar, additional, Abou-Alfa, Ghassan K., additional, Abrahm, Janet L., additional, Abrams, Jeffrey S., additional, Abramson, Jeremy S., additional, Aisner, Dara L., additional, Alonso-Basanta, Michelle, additional, Anampa, Jesus, additional, Anderson, Megan E., additional, Antonarakis, Emmanuel S., additional, Aplenc, Richard, additional, Appelbaum, Frederick R., additional, Araujo, Luiz H., additional, Asban, Ammar, additional, Ashwood, Edward, additional, Awan, Farrukh T., additional, Aylward, Juliet L., additional, Balar, Arjun V., additional, Balentine, Courtney J., additional, Barta, Stefan K., additional, Bartlett, Nancy, additional, Basen-Engquist, Karen, additional, Beaupin, Lynda Kwon, additional, Berkowitz, Ross S., additional, Berry, Donald A., additional, Bevers, Therese, additional, Boggess, John F., additional, Brahmer, Julie R., additional, Brown, Janet, additional, Brown, Karen, additional, Brown, Powel, additional, Browner, Ilene, additional, Bunn, Paul A., additional, Burns, William R., additional, Byrd, John C., additional, Cadoo, Karen, additional, Carbone, David P., additional, Carter, H. Ballentine, additional, Castillo, Jorge J., additional, Chang, Alfred E., additional, Chang, Eric, additional, Chanock, Stephen J., additional, Chapuy, Claudia I., additional, Chauhan, Vikash P., additional, Chen, Herbert, additional, Chen, Ronald C., additional, Cheung, Nai-Kong V., additional, Choe, Jennifer H., additional, Christian, Michaele C., additional, Cinciripini, Paul M., additional, Clarke, Michael F., additional, Coleman, Robert E., additional, Coleman, Robert L., additional, Coletta, Adriana M., additional, Collins, Jerry M., additional, Connors, Jean M., additional, Cools, Michael, additional, Coombes, Kevin R., additional, Cortes, Jorge, additional, Costa, Mauro W., additional, Covey, Anne, additional, Cowan, Kenneth H., additional, Crane, Christopher H., additional, Crawford, Jeffrey, additional, Crooks, Kristy, additional, Culkin, Daniel J., additional, Czito, Brian G., additional, Dalerba, Piero, additional, Dalmau, Josep, additional, Dang, Mai, additional, D'Angelica, Michael, additional, Davies, Kurtis D., additional, Davis, Myrtle, additional, Dea, Nicolas, additional, De Jesus-Acosta, Ana, additional, DeMarzo, Angelo M., additional, DeWeese, Theodore L., additional, Diehn, Maximilian, additional, Digumarthy, Subba R., additional, Dispenzieri, Angela, additional, Do, Khanh T., additional, Dobrenkov, Konstantin, additional, Dome, Jeffrey S., additional, Doroshow, James H., additional, Dorsey, Jay F., additional, Dubard-Gault, Marianne, additional, DuBois, Steven G., additional, Duda, Dan G., additional, Dunlop, Malcolm, additional, Duska, Linda R., additional, Duvic, Madeleine, additional, El Dika, Imane, additional, El-Serag, Hashem, additional, Engelmann, Jeffrey M., additional, Ettinger, David S., additional, Fashoyin-Aje, Lola A., additional, Fearon, Eric R., additional, Ford, James M., additional, Franklin, Wilbur A., additional, Freer, Phoebe E., additional, Freidlin, Boris, additional, Freifeld, Alison G., additional, Friedlander, Terence W., additional, Friedman, Debra L., additional, Fuller, Arian F., additional, Galluzzi, Lorenzo, additional, Gebhardt, Mark C., additional, George, Daniel J., additional, Geyer, Mark B., additional, Giaccia, Amato J., additional, Gilbert, Mark R., additional, Goldner, Whitney, additional, Goldstein, Donald P., additional, Goodman, Annekathryn, additional, Goodman, Karyn A., additional, Gordon, Kathleen, additional, Graeff-Armas, Laura, additional, Greenstein, Alexander J., additional, Grossman, Stuart A., additional, Grupp, Stephan, additional, Gupta, Arjun, additional, Haider, Irfanullah, additional, Haigentz, Missak, additional, Hainsworth, John D., additional, Haithcock, Benjamin E., additional, Hallemeier, Christopher L., additional, Hanash, Samir, additional, Hanrahan, Aphrothiti J., additional, Harding, James, additional, Harrison, Michael R., additional, Hasham, Muneer G., additional, Hawk, Ernest, additional, Hayman, Jonathan, additional, Heinlen, Jonathan E., additional, Henry, N. Lynn, additional, Herman, Joseph, additional, Hobbs, Brian P., additional, Holen, Ingunn, additional, Horn, Leora, additional, Horowitz, Neil S., additional, Horwitz, Steven M., additional, Houghton, Odette, additional, Howard, Scott C., additional, Hudis, Clifford A., additional, Hunger, Stephen P., additional, Hurria, Arti, additional, Ilson, David H., additional, Im, Annie, additional, Iyer, Gopa, additional, Jaffee, Elizabeth M., additional, Jagsi, Reshma, additional, Jain, Rakesh K., additional, Jarnagin, William, additional, Jatoi, Aminah, additional, Jhingran, Anuja, additional, Johnson, David H., additional, Johnston, Brian, additional, Johnston, Patrick G., additional, Judy, Kevin D., additional, Kachnic, Lisa A., additional, Kaidar-Person, Orit, additional, Kalva, Sanjeeva, additional, Kamin, Deborah Y., additional, Kantarjian, Hagop, additional, Karakousis, Giorgos, additional, Karam-Hage, Maher, additional, Kaskas, Nadine M., additional, Kastan, Michael B., additional, Katabi, Nora, additional, Kaul, Daniel R., additional, Kelley, Scott R., additional, Kemeny, Nancy, additional, Kent, Erin E., additional, Kepp, Oliver, additional, Khagi, Simon, additional, Kilgore, Joshua E., additional, Kim, D. Nathan, additional, Kleinschmidt-DeMasters, Bette K., additional, Korn, Edward L., additional, Kroemer, Guido, additional, Ku, Geoffrey Y., additional, Kummar, Shivaani, additional, Ky, Bonnie, additional, Laheru, Daniel A., additional, Lambert, Paul F., additional, Lawler, Mark, additional, Le-Rademacher, Jennifer G., additional, Lee, John Y.K., additional, Lee, Nancy Y., additional, Lee, Susanna L., additional, Leeman, Jonathan E., additional, Linkermann, Andreas, additional, Liu, Jinsong, additional, Lo, Simon, additional, Locasale, Jason W., additional, Loprinzi, Charles L., additional, Lowery, Maeve, additional, Ludwig, Emmy, additional, Lunning, Matthew A., additional, Lustig, Robert A., additional, Machtay, Mitchell, additional, Mackall, Crystal, additional, Mahvi, David A., additional, Mahvi, David M., additional, Maity, Amit, additional, Majithia, Neil, additional, Malumbres, Marcos, additional, Maresso, Karen Colbert, additional, Martin, John D., additional, Matsuo, Koji, additional, Matthews, Natalie H., additional, Mauro, Lauren, additional, Mayer, R. Samuel, additional, McCaskill-Stevens, Worta, additional, McNamara, Megan A., additional, Mehta-Shah, Neha, additional, Merritt, Robert E., additional, Milowsky, Matthew I., additional, Minasian, Lori M., additional, Mitchell, Tara C., additional, Mitsis, Demytra, additional, Mollica, Michelle, additional, Mooney, Margaret, additional, Moustafa, Farah, additional, Nabati, Lida, additional, Naidoo, Jarushka, additional, Narang, Amol, additional, Nelson, Heidi, additional, Nelson, William G., additional, Nesbit, Suzanne, additional, Niglas, Mark, additional, O'Connor, Tracey, additional, Offit, Kenneth, additional, Onciu, Mihaela, additional, O’Reilly, Eileen M., additional, Ostrander, Elaine A., additional, Pappas-Taffer, Lisa, additional, Pardoll, Drew, additional, Park, Jae H., additional, Patel, Anery, additional, Patel, Anish J., additional, Patierno, Steven R., additional, Pavletic, Steven Z., additional, Phillips, Peter C., additional, Post, Miriam D., additional, Pruitt, Amy A., additional, Querfeld, Christiane, additional, Rabius, Vance A., additional, Rajkumar, S. Vincent, additional, Ramadan, Mohammad O., additional, Rankin, Erinn B., additional, Reddy, Sushanth, additional, Reid, Michael A., additional, Reznik, Scott, additional, Rizack, Tina, additional, Robinson, Jason D., additional, Robinson-Bostom, Leslie, additional, Rodriguez-Galindo, Carlos, additional, Romesser, Paul B., additional, Rosen, Steven T., additional, Rosenfeld, Myrna R., additional, Rosenthal, Nadia, additional, Ross, Meredith, additional, Rowland, Julia H., additional, Russell, Anthony H., additional, Sabel, Michael S., additional, Sahgal, Arjun, additional, Salinas, Ryan D., additional, Salo-Mullen, Erin E., additional, Salto-Tellez, Manuel, additional, Sanderson, Sydney M., additional, Sandlund, John T., additional, Santana, Victor M., additional, Savage, Michelle, additional, Schreiber, Eric C., additional, Schuchter, Lynn, additional, Schultz, Liora, additional, Seiden, Michael V., additional, Sellers, Morgan M., additional, Shah, Payal D., additional, Shia, Jinru, additional, Shilo, Konstantin, additional, Small, Eric, additional, Smith, Angela B., additional, Snow, Stephen N., additional, Solit, David B., additional, Sood, Anil K., additional, Soto-Perez-de-Celis, Enrique, additional, Sparano, Joseph A., additional, Spiegelman, Vladimir S., additional, Spunt, Sheri L., additional, Stadler, Zsofia K., additional, Steensma, David P., additional, Stone, Richard M., additional, Stranne, Steven Kent, additional, Stratton, Kelly, additional, Sugden, Bill, additional, Swanson, Andrew M., additional, Tallman, Martin S., additional, Talmadge, James E., additional, Teachey, David T., additional, Teba, Catalina V., additional, Tefferi, Ayalew, additional, Teh, Bin Tean, additional, Teng, Joyce M.C., additional, Tepper, Joel E., additional, Thaker, Premal H., additional, Thrift, Aaron P., additional, Tran, Arthur-Quan, additional, Triska, Grace, additional, Trump, Donald, additional, Tsai, Kenneth, additional, Tseng, Chia-Lin, additional, Tseng, Diane, additional, Van Schaeybroeck, Sandra, additional, Van Tine, Brian A., additional, Vanness, Erin R., additional, Varadhachary, Gauri, additional, Varella-Garcia, Marileila, additional, Wahl, Richard L., additional, Walsh, Michael F., additional, Wang, Thomas, additional, Weiss, Jared, additional, Weissman, Irving L., additional, Westin, Shannon N., additional, White, Jeffrey D., additional, Wilson, Richard, additional, Wong, Richard J., additional, Wood, Gary S., additional, Xu, Yaohui G., additional, Xu-Welliver, Meng, additional, Yust-Katz, Shlomit, additional, Zagar, Timothy, additional, Zeman, Elaine M., additional, Zhang, Tian, additional, and Zwiebel, James A., additional

Published
2020
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157. Clinical features, management and outcomes of intermittent exotropia in the United Kingdom

Author

Clarke, Michael Patrick

Subjects
618.920977
Abstract

Intermittent Exotropia [X(T)], is a common form of childhood strabismus. Clinical decision making for this condition is hampered by lack of evidence from well designed prospective studies. This thesis consists of five papers authored by myself and my collaborators, and a linking statement placing these papers in a scientific context. The first two papers describe the development and clinical utility of a novel scoring system for the control of X(T), which can be used to assess the progress of the condition and the effect of treatment on this parameter. This scoring system, the Newcastle Control Score for Intermittent Exotropia, consists of a parent/carer reported 'Home' component and an objective, 'Clinic', assessment of the ease of realignment of the exotropia in response to disruption of fusion by a cover test. The second two papers describe the establishment of relevant age related normal ranges of a new test of distance stereoacuity, the Frisby Davis Distance Stereotest (FDiffi ), and the application of this test to a cohort of children with X(T). In contrast to previous studies, we found an 'all or none' pattern of distance stereoacuity in X(T), rather than a gradual decline in distance stereoacuity. The final paper describes the initial results of a prospective study of a cohort of 460 children with X(T), recruited in 26 centres, which examined their clinical phenotype and management in the first year following recruitment. The striking finding of this study was that over half the children in the cohort received no treatment in the first year after diagnosis, suggesting that decision making by professionals in this condition was hampered by a lack of evidence about natural history and treatment outcomes. The linking statement concludes with a brief description of related and ongoing research by our group and others.

Published
2013

161. Effects of a Conversation-Based Intervention on the Linguistic Skills of Children with Motor Speech Disorders Who Use Augmentative and Alternative Communication

Author

Soto, Gloria and Clarke, Michael T.

Abstract

Purpose: This study was conducted to evaluate the effects of a conversation-based intervention on the expressive vocabulary and grammatical skills of children with severe motor speech disorders and expressive language delay who use augmentative and alternative communication. Method: Eight children aged from 8 to 13 years participated in the study. After a baseline period, a conversation-based intervention was provided for each participant, in which they were supported to learn and use linguistic structures essential for the formation of clauses and the grammaticalization of their utterances, such as pronouns, verbs, and bound morphemes, in the context of personally meaningful and scaffolded conversations with trained clinicians. The conversations were videotaped, transcribed, and analyzed using the Systematic Analysis of Language Transcripts (SALT; Miller & Chapman, 1991). Results: Results indicate that participants showed improvements in their use of spontaneous clauses, and a greater use of pronouns, verbs, and bound morphemes. These improvements were sustained and generalized to conversations with familiar partners. Conclusion: The results demonstrate the positive effects of the conversation-based intervention for improving the expressive vocabulary and grammatical skills of children with severe motor speech disorders and expressive language delay who use augmentative and alternative communication. Clinical and theoretical implications of conversation-based interventions are discussed and future research needs are identified.

Published
2017
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162. Usp16 contributes to somatic stem-cell defects in Down’s syndrome

Author

Adorno, Maddalena, Sikandar, Shaheen, Mitra, Siddhartha S, Kuo, Angera, Nicolis di Robilant, Benedetta, Haro-Acosta, Veronica, Ouadah, Youcef, Quarta, Marco, Rodriguez, Jacqueline, Qian, Dalong, Reddy, Vadiyala M, Cheshier, Samuel, Garner, Craig C, and Clarke, Michael F

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Genetics, Stem Cell Research, Intellectual and Developmental Disabilities (IDD), Down Syndrome, Stem Cell Research - Nonembryonic - Non-Human, Brain Disorders, 1.1 Normal biological development and functioning, Aetiology, Underpinning research, 2.1 Biological and endogenous factors, Adult Stem Cells, Animals, Cell Proliferation, Cellular Senescence, Chromosomes, Human, Pair 21, Cyclin-Dependent Kinase Inhibitor p16, Disease Models, Animal, Epithelium, Female, Fibroblasts, Gene Dosage, Gene Expression Regulation, Hematopoietic Stem Cells, Humans, Mammary Glands, Animal, Mice, Molecular Targeted Therapy, Neural Stem Cells, Trisomy, Ubiquitin Thiolesterase, Ubiquitination, General Science & Technology
Abstract

Down's syndrome results from full or partial trisomy of chromosome 21. However, the consequences of the underlying gene-dosage imbalance on adult tissues remain poorly understood. Here we show that in Ts65Dn mice, which are trisomic for 132 genes homologous to genes on human chromosome 21, triplication of Usp16 reduces the self-renewal of haematopoietic stem cells and the expansion of mammary epithelial cells, neural progenitors and fibroblasts. In addition, Usp16 is associated with decreased ubiquitination of Cdkn2a and accelerated senescence in Ts65Dn fibroblasts. Usp16 can remove ubiquitin from histone H2A on lysine 119, a critical mark for the maintenance of multiple somatic tissues. Downregulation of Usp16, either by mutation of a single normal Usp16 allele or by short interfering RNAs, largely rescues all of these defects. Furthermore, in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and postnatal neural progenitors, whereas downregulation of USP16 partially rescues the proliferation defects of Down's syndrome fibroblasts. Taken together, these results suggest that USP16 has an important role in antagonizing the self-renewal and/or senescence pathways in Down's syndrome and could serve as an attractive target to ameliorate some of the associated pathologies.

Published
2013

166. Special education needs co-ordinators perceptions of local education support services with particular reference to pupils with social, emotional and behavioural difficulties : A case study of Luton local authority

Author

Clarke, Michael J.

Subjects
371.9
Abstract

This Thesis is a case study of Luton Local Authority (LA) and its approach to delivering special educational needs (SEN) support services to Luton schools. The study concentrates on the delivery of behaviour support to schools and pupils and explores how pupils with social emotional and behavioural difficulties may be included or excluded from school as a result of this support. The case study incorporates a multi-method research strategy, which sought to gain an LA perspective of service delivery by involving all Luton's special educational needs co-ordinators (SENCOs) in a questionnaire about behaviour support service delivery to their schools. The case study approach also involved using semi-structured interviews with thirteen Luton SENCOs. In Luton the delivery mechanism for SEN support services is through termly meetings with schools. These school consultation meetings (SCMs) are the strategy used by the LA to deliver support services. The study involved observing eight SCMs so that first hand knowledge of the delivery process could be investigated. The data collected is presented in three layers. Layer one Presents the questionnaire data, layer two presents the inter-view data and layer three presents the observation data. All three data sets are presented under the key research questions. The three key research questions are: 1) How do schools use School Consultation Meetings to access Behaviour Support? 2) Who from the LA carries out the Behaviour Support work with the Schools? 3) Why have SEN support services, which focus on pupil deficits instead of pupil strengths? The case study found that the concept of SEN is a contentious and complex issue, which is subject to redefinition over time. The English education system is viewed as being segregationist and the concept of inclusion is found to apply to different pupils along class, ethnic and gender dimensions.

Published
2008

177. Conversational interaction between children using communication aids and their peers

Author

Clarke, Michael Timothy

Subjects
418.0083
Abstract

This thesis uses the principles and practices of Conversation Analysis in an examination of conversational interaction between non-speaking children with Cerebral Palsy using voice output communication aids (VOCAs) and their speaking peers. In order to capture the unique and subtle ways in which these interactions are organised this thesis presents a detailed examination of three dyads. Many children with Cerebral Palsy experience profound difficulty producing intelligible speech. Such children may be provided with communication aids, including VOCAs, as an alternative communication modality. Despite recognition of the value of children's peer relationships, few studies have focused on interaction between children using communication aids and their peers. The central aim of this thesis is to examine how such interactions are organised. In particular, this work is concerned with examining the role of the speaking partners in conversational organisation, how VOCAs contribute to interaction and how conversations are organised when non-speaking children participate through unintelligible vocalisations and non-verbal actions. A significant feature of each dyad is the work that speaking partners do in organising particular types of structural integrity for the conversation. This includes speaking partners locating the production of VOCA mediated turns and non-verbal actions within specific sequential contexts. Such practices provide frameworks within which VOCA mediated contributions and non-verbal actions may be understood. VOCA use initiated outside such predefined sequential locations may be realised problematically. Speaking children may also seek to organise the interaction through the treatment of their partners' unintelligible vocalisations and non-verbal actions with rich meaning. In so doing, speaking partners portray children with Cerebral Palsy with particular types of competence. By revealing the ways in which these children organise conversational interaction, this thesis highlights implications for intervention by Speech and Language Therapists who support children using communication aids in schools.

Published
2005

183. Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions

Author

Zarour, Luai R., Anand, Sudarshan, Billingsley, Kevin G., Bisson, William H., Cercek, Andrea, Clarke, Michael F., Coussens, Lisa M., Gast, Charles E., Geltzeiler, Cristina B., Hansen, Lissi, Kelley, Katherine A., Lopez, Charles D., Rana, Shushan R., Ruhl, Rebecca, Tsikitis, V. Liana, Vaccaro, Gina M., Wong, Melissa H., and Mayo, Skye C.

Published
2017
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185. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Author

Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., and Baric, Ralph S.

Published
2020
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188. The Functional Vision for Communication Questionnaire (FVC-Q): Exploring Parental Report of Non-Speaking Children's Fixation Skills Using a Structured History-Taking Approach.

Author

Sargent, Jenefer, Griffiths, Tom, Clarke, Michael T., Bates, Kim, Macleod, Katrina, and Swettenham, John

Subjects
MEDICAL history taking, CHILDREN with disabilities, VISION testing, RESEARCH methodology evaluation, PARENT attitudes, DESCRIPTIVE statistics, CEREBRAL palsy, RETROSPECTIVE studies, NONVERBAL communication, RESEARCH methodology, PARENTS of children with disabilities, COMPARATIVE studies, VISUAL acuity, EYE movements, PSYCHOSOCIAL factors, CHILDREN
Abstract

This paper explores whether a structured history-taking tool yields useful descriptions of children's looking skills. Parents of 32 children referred to a specialist communication clinic reported their child's looking skills using the Functional Vision for Communication Questionnaire (FVC-Q), providing descriptions of single object fixation, fixation shifts between objects and fixation shifts from object to person. Descriptions were compared with clinical assessment. 24/32 children were reported to have some limitation in fixation. Limitation was subsequently seen in 30/32 children. Parental report and assessment agreed fully in 23/32 (72%). The largest area of discrepancy was object-person fixation shifts, with five children not observed to show this behavior despite its being reported. Findings indicate a structured questionnaire yields description of fixations, which correspond well with clinical assessment. Descriptions supported discussion between parents and clinicians. It is proposed that the FVC-Q is a valuable tool in supporting clinicians in eliciting information about fixation skills. [ABSTRACT FROM AUTHOR]

Published
2024
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194. List of Contributors

Author

Bloch, Steven, primary, Chantry, Jane, additional, Clarke, Michael, additional, Cowan, Donna, additional, Crombie, Sarah, additional, da Silva Ramos, Sara, additional, Dewsbury, Guy, additional, Fairhurst, Charlie, additional, Griffiths, Tom, additional, Harbach, Geoff, additional, Jamieson, Matthew, additional, Judge, Simon, additional, Kanumuru, Lakshmi Krisha, additional, Larsen, Layla Bashir, additional, Linskell, Jeremy, additional, Long, Dave, additional, McConnell, Joanne, additional, Najafi, Ladan, additional, Newman, Jemma, additional, Nisbet, Paul, additional, Oprea, Paul, additional, Price, Katie, additional, Sirlantzis, Konstantinos, additional, and Woodcock, Alan, additional

Published
2019
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