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516 results on '"Choi, K-C"'

154. Large Sample Properties of Mixture Models with Covariates for Competing Risks

Author

Choi, K. C. and Zhou, X.

Subjects
*COMPETING risks, *ANALYSIS of covariance, *ASYMPTOTES
Abstract

We study the large-sample properties of a class of parametric mixture models with covariates for competing risks. The models allow general distributions for the survival times and incorporate the idea of long-term survivors. Asymptotic results are obtained under a commonly assumed independent censoring mechanism and some modest regularity conditions on the survival distributions. The existence, consistency, and asymptotic normality of maximum likelihood estimators for the parameters of the model are rigorously derived under general sufficient conditions. Specific conditions for particular models can be derived from the general conditions for ready check. In addition, a likelihood-ratio statistic is proposed to test various hypotheses of practical interest, and its asymptotic distribution is provided. [Copyright &y& Elsevier]

Published
2002
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155. Immunohistochemical differentiation of basal cell epithelioma from cutaneous appendages using monoclonal anti-glycoprotein antibody TNKH1. Its application in Mohs' micrographic surgery.

Author

Setoyama, Mitsuru, Hashimoto, Ken, Dinehart, Scott M., Choi, Kyu C., Ishihara, Masahiko, Predeteanu, George S., Tronnier, Michael, Pietruk, Teresa, Nakanishi, Takafumi, Setoyama, M, Hashimoto, K, Dinehart, S M, Choi, K C, Ishihara, M, Predeteanu, G S, Tronnier, M, Pietruk, T, and Nakanishi, T

Published
1990
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157. International Congress on Hormonal Steroids and Hormones and Cancer: Potential role of gonadotrophin-releasing hormone (GnRH)-I and GnRH-II in the ovary and ovarian cancer

Author

Kang, S K, Choi, K-C, Yang, H-S, and Leung, P C K

Abstract

Gonadotrophin-releasing hormone (GnRH) functions as a key neuroendocrine regulator of the hypothalamic-pituitary-gonadal axis. In addition to the hypothalamus and pituitary gland, GnRH and its receptor have been detected in other reproductive tissues including the gonads, placenta and tumours arising from these tissues. Recently, a second form of GnRH (GnRH-II) and type II GnRH receptor have been found in normal ovarian surface epithelium and neoplastic counterparts. The two types of GnRH may play an important role as an autocrine/paracrine regulator of reproductive functions and ovarian tumour growth. In this review, the distribution and potential roles of GnRH-I/-II and their GnRH receptors in the ovarian cells and ovarian cancer will be discussed.

Published
2003

160. Effects of L-arginine on cyclosporin-induced alterations of vascular NO/cGMP generation.

Author

Lee, J, Kim, S W, Kook, H, Kang, D G, Kim, N H, and Choi, K C

Abstract

Cyclosporin (CsA)-induced vascular dysfunction has been attributed to a diminished role of the nitric oxide (NO)/cGMP-mediated vasodilator mechanism. The present study was aimed at investigating whether L-arginine, the substrate of NO synthesis, ameliorates CsA-induced vascular dysfunction.

Published
1999
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162. Comparison of 5-hydroxytryptamine1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells.

Author

Beck, S G, Choi, K C, and List, T J

Abstract

5-hydroxytryptamine (5-HT) hyperpolarizes hippocampal pyramidal cells in both areas CA1 and CA3 through an increase in potassium conductance. The receptor mediating the hyperpolarization in CA1 has been characterized as the 5-HT1A receptor, but has not been identified in area CA3. Intracellular recording techniques were used to record from CA1 and CA3 pyramidal cells in a hippocampal slice preparation. 5-HT agonists and antagonists were applied in known concentrations by bath perfusion. Antagonists were tested alone and for their ability to block the hyperpolarization elicited by 5-HT. The 5-HT1 agonist 5-carboxyamidotryptamine and 5-HT were full agonists and the 5-HT1A-selective ligand 8-hydroxydipropyl-aminotetralin hydrobromide was a partial agonist in both CA3 and CA1. The rank order potency was 5-carboxyamidotryptamine > 8-hydroxydipropyl-aminotetralin hydrobromide > 5-HT for both regions. The agonists were a half-log unit less potent and the maximum response elicited by 5-carboxyamidotryptamine and 5-HT was greater in area CA3 than in area CA1. The selective 5-HT1A antagonist BMY 7378 and the 5-HT1A/2 antagonist spiperone were competitive in area CA1, but insurmountable in area CA3. Other 5-HT antagonists that were not effective in blocking the 5-HT-mediated hyperpolarization included ketanserin, odansetron and BRL 24924. Based on these results, we conclude that the hyperpolarization elicited by 5-HT in areas CA1 and CA3 is mediated by the 5-HT1A receptor. However, there are significant differences in the nature of the 5-HT1A receptor-mediated hyperpolarization that may be attributed to differences in receptor-effector number, receptor-effector coupling and/or the structure of the recognition site.

Published
1992

163. A Merchant Ship Size Optimization Model.

Author

NAVAL POSTGRADUATE SCHOOL MONTEREY CA, Choi,K C, NAVAL POSTGRADUATE SCHOOL MONTEREY CA, and Choi,K C

Abstract

This paper analyzes how a shipowner or charterer may determine the specification of optimal ship size for a given route with respect to certain market requirements. The theory of optimal ship size, a methodology for estimating scale economics, and the various factors affecting ship size are examined using a typical conventional cargo ship and bulk cargo carriers based on shipowners' cost data. (Author)

Published
1983

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