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398 results on '"Choi, Jung-Min"'

154. A High-Affinity Protein Binder that Blocks the IL-6/STAT3 Signaling Pathway Effectively Suppresses Non–Small Cell Lung Cancer

Author

Lee, Joong-jae, primary, Kim, Hyun Jung, additional, Yang, Chul-Su, additional, Kyeong, Hyun-Ho, additional, Choi, Jung-Min, additional, Hwang, Da-Eun, additional, Yuk, Jae-Min, additional, Park, Keunwan, additional, Kim, Yu Jung, additional, Lee, Seung-Goo, additional, Kim, Dongsup, additional, Jo, Eun-Kyeong, additional, Cheong, Hae-Kap, additional, and Kim, Hak-Sung, additional

Published
2014
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159. Fast Kalman/LMS algorithms on the strong multipath channel

Author

Jong-Wha Chong, Choi Jung Min, Jae Hong Park, and Jung-Su Kim

Subjects
Least mean squares filter, Sequence, Control theory, Computer science, Payload (computing), Kalman filter, Algorithm, Computer Science::Information Theory, Numerical stability
Abstract

We present a decision feedback equalizer (DFE) based on the proposed hybrid structure, which consists of the fast Kalman and LMS algorithm, to guarantee the fast convergence speed, computational complexity and numerical stability on the strong multipath channels. The LMS algorithm recommended by ATSC for HDTV does not guarantee TOV (threshold of visibility) on the strong multipath channels during the training period. Since the fast Kalman algorithm is not only numerically unstable but it also has high computational complexity, we proposed a hybrid structure to solve both of these problems. The fast Kalman algorithm is applied during the training sequence for the fast convergence, and then LMS algorithm is used to reduce the computational complexity and avoid the instability problem for the payload data part. The simulation results demonstrate that our hybrid structure is numerically stable with fast convergence speed and it overcomes the strong multipath channel.

Published
2003
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160. Functional characterization of Mucin-Associated Surface Protein (MASP) in the human parasite Trypanosoma cruzi

Author

Choi, Jung Min and Choi, Jung Min

Abstract

MASPs are members of a multigenic family recently identified during the sequencing of the T. cruzi CL Brener genome. This family contains around 1,400 members, consisting of approximately 6% of the whole coding genes. Highly conserved N- and C-terminal domains, which encode a signal peptide and GPI-anchor addition site respectively, and a hypervariable central region, characterize MASPs. Members of this family are predominantly expressed in the infective trypomastigote form. We hypothesized that members of the T. cruzi MASP protein family play a major role in the interaction of the parasite with the host cell. In order to investigate a putative role for T. cruzi MASP at the host-pathogen interface, we have used MASP as a bait protein against the human proteome using a high-throughput platform that we have recently established for identifying protein-protein interactions between pathogens and theirs hosts. Yeast two-hybrid screens identified human SNAPIN as one of two major MASP interacting proteins. SNAPIN is a member of the SNARE protein complex, which may have a role in a calcium-dependent exocytosis. The MASP-SNAPIN interaction was further validated using in vivo co-Affinity Purification and in vitro pull-down assays. Immunofluorescence assays showed human SNAPIN is recruited to the parasite surface during invasion. Co-localization experiments indicated that SNAPIN is associated with the late endosomes and lysosomes. Supporting our initial hypothesis, SNAPIN depletion using siRNA oligomers in HeLa cells and snapin-/- in Mouse Embryonic Fibroblast (MEF) cells significantly inhibited T. cruzi invasion, suggesting a role for SNAPIN in this process. Lysosomes in snapin-/- MEF cells displayed aberrant morphology and distribution and the parasites did not recruit host lysosomes efficiently when compared to wild-type cells. This was likely due to an impaired calcium-dependent lysosome exocytosis in snapin-/- MEF cells. SNAPIN was translocated to the plasma membrane upon

Published
2012

167. Key theoretical distinctions in community-based health interventions.

Author

Murphy, John W., Franz, Berkeley A., and Choi, Jung Min

Subjects
COMMUNITY-based participatory research, HEALTH programs, SOCIAL theory, COMMUNITY-based programs
Abstract

The move to community-based practice is often accompanied by doubts about the veracity of the research or clinical data that might be generated. Critics contend that the introduction of subjectivity that accompanies this maneuver obscures the empirical side of social existence, and thus compromises the discovery of facts. But this erroneous conclusion rests on confusion about several key philosophical distinctions that are discussed in this paper. The clarification that results from addressing these issues enhances the utility of community-based health strategies. [ABSTRACT FROM AUTHOR]

Published
2016
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168. Euduboscquella costata n. sp. (Dinoflagellata, Syndinea), an Intracellular Parasite of the Ciliate Schmidingerella arcuata: Morphology, Molecular Phylogeny, Life Cycle, Prevalence, and Infection Intensity.

Author

Jung, Jae‐Ho, Choi, Jung Min, Coats, D. Wayne, and Kim, Young‐Ok

Subjects
*DINOFLAGELLATES, *MOLECULAR phylogeny, *INTRACELLULAR pathogens, *CILIATA, *TINTINNIDA, *RIBOSOMAL RNA
Abstract

The syndinean dinoflagellate Euduboscquella costata n. sp., an intracellular parasite of the tintinnid ciliate Schmidingerella arcuata, was discovered from Korean coastal water in November of 2013. Euduboscquella costata parasitized in about 62% of the host population, with infection intensity (= number of trophonts in a single host cell) ranging from 1 to 8. Based on morphology and nuclear 18S ribosomal RNA gene sequences, the parasite is new to science. Euduboscquella costata n. sp. had an infection cycle typical of the genus, but had morphological and developmental features that distinguished it from congeneric species. These features include: (1) episome of the trophont with 25-40 grooves converging toward the center of the shield; (2) a narrow, funnel-shaped lamina pharyngea extending from the margin of the episomal shield to the nucleus; (3) persistence of grooves during extracellular development (sporogenesis); (4) a single food vacuole during sporogenesis; (5) separation of sporocytes early in sporogenesis, regardless of type of spore formed; and (6) dinospore size (ca. 14 μm in length) and shape (bulbous episome with narrower, tapering hyposome). After sporogenesis, E. costata produced four different types of spore that showed completely identical 18S rRNA gene sequences. The gene sequence was completely identical with a previously reported population, Euduboscquella sp. ex S. arcuata, from Assawoman Bay, USA, indicating that the two populations are likely conspecific. Favella ehrenbergii, a widely recorded tintinnid known to host Euduboscquella spp., co-occurred with S. arcuata, but was not infected by E. costata in field samples or during short-term, cross-infection experiments. [ABSTRACT FROM AUTHOR]

Published
2016
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