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151. Study on the absorption of ketoprofen topically administered in man: comparison between tissue and plasma levels.

Author

Ballerini R, Casini A, Chinol M, Mannucci C, Giaccai L, and Salvi M

Subjects
Administration, Topical, Adult, Female, Humans, Ketoprofen administration & dosage, Ketoprofen blood, Male, Skin Absorption, Synovial Fluid metabolism, Time Factors, Ketoprofen metabolism, Phenylpropionates metabolism
Abstract

In this study the transcutaneous passage of ketoprofen (gel) topically administered and its distribution in the inner part of the knee-joint were evaluated in six patients. The ketoprofen concentrations detected were: 4.70 mcg/g +/- 3.87 in the intra-articular adipose tissue; 2.35 mcg/g +/- 2.41 in the capsular sample and 1.31 mcg/g +/- 0.89 in the synovial fluid. Plasma concentrations of the drug were also examined. In the samples studied, the ketoprofen levels amounted to about one hundred times higher than the plasma concentrations.

Published
1986

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