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152. AutoNet-Generated Deep Layer-Wise Convex Networks for ECG Classification

Author

Shen, Yanting, Lu, Lei, Zhu, Tingting, Wang, Xinshao, Clifton, Lei, Chen, Zhengming, Clarke, Robert, and Clifton, David A.

Abstract

The design of neural networks typically involves trial-and-error, a time-consuming process for obtaining an optimal architecture, even for experienced researchers. Additionally, it is widely accepted that loss functions of deep neural networks are generally non-convex with respect to the parameters to be optimised. We propose the Layer-wise Convex Theorem to ensure that the loss is convex with respect to the parameters of a given layer, achieved by constraining each layer to be an overdetermined system of non-linear equations. Based on this theorem, we developed an end-to-end algorithm (the AutoNet) to automatically generate layer-wise convex networks (LCNs) for any given training set. We then demonstrate the performance of the AutoNet-generated LCNs (AutoNet-LCNs) compared to state-of-the-art models on three electrocardiogram (ECG) classification benchmark datasets, with further validation on two non-ECG benchmark datasets for more general tasks. The AutoNet-LCN was able to find networks customised for each dataset without manual fine-tuning under 2 GPU-hours, and the resulting networks outperformed the state-of-the-art models with fewer than 5% parameters on all the above five benchmark datasets. The efficiency and robustness of the AutoNet-LCN markedly reduce model discovery costs and enable efficient training of deep learning models in resource-constrained settings.

Published
2024
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157. A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas

Author

Jang, Ja-Young, Hwang, Inah, Pan, Heng, Yao, Jun, Alinari, Lapo, Imada, Eddie, Zanettini, Claudio, Kluk, Michael J., Wang, Yizhe, Lee, Yunkyoung, Lin, Hua V., Huang, Xiangao, Liberto, Maurizio Di, Chen, Zhengming, Ballman, Karla V., Cantley, Lewis C., Marchionni, Luigi, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert A., Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, and Paik, Jihye

Subjects
Lymphomas -- Genetic aspects -- Development and progression -- Care and treatment, Genetic transcription -- Health aspects, Transcription factors -- Health aspects, Health care industry
Abstract

Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of mantle cell lymphoma (MCL), we identified a set of transcription factors (TFs) including FOXO1, EBF1, PAX5, and IRF4 that are essential for MCL propagation. Integrated chromatin immunoprecipitation and sequencing (ChIP-Seq) with transcriptional network reconstruction analysis revealed FOXO1 as a master regulator that acts upstream in the regulatory TF hierarchy. FOXO1 is both necessary and sufficient to drive MCL lineage commitment through supporting the lineage-specific transcription programs. We further show that FOXO1, but not its close paralog FOXO3, can reprogram myeloid leukemia cells and induce B-lineage gene expression. Finally, we demonstrate that cpd10, a small molecule identified from an enriched FOXO1 inhibitor library, induces a robust cytotoxic response in MCL cells in vitro and suppresses MCL progression in vivo. Our findings establish FOXO1 inhibition as a therapeutic strategy targeting lineage-driven transcriptional addiction in MCL., Introduction Mantle cell lymphoma (MCL) is a lethal mature B cell lymphoma manifested by cyclin D1 overexpression due to a t(11;14) (q13;q32) chromosomal translocation and mutations of genes associated with [...]

Published
2022
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160. Prospective evaluation of the relevance of Epstein–Barr virus antibodies for early detection of nasopharyngeal carcinoma in Chinese adults.

Author

Yang, Ling, Kartsonaki, Christiana, Simon, Julia, Yao, Pang, Guo, Yu, Lv, Jun, Walters, Robin G, Chen, Yiping, Fry, Hannah, Avery, Daniel, Yu, Canqing, Jin, Jianrong, Mentzer, Alexander J, Allen, Naomi, Butt, Julia, Hill, Michael, Li, Liming, Millwood, Iona Y, Waterboer, Tim, and Chen, Zhengming

Subjects
VIRAL antibodies, IMMUNOGLOBULIN A, NASOPHARYNX cancer, IMMUNOGLOBULIN G, SEROLOGY
Abstract

Background Epstein–Barr virus (EBV) is a major cause of nasopharyngeal carcinoma (NPC) and measurement of different EBV antibodies in blood may improve early detection of NPC. Prospective studies can help assess the roles of different EBV antibodies in predicting NPC risk over time. Methods A case-cohort study within the prospective China Kadoorie Biobank of 512 715 adults from 10 (including two NPC endemic) areas included 295 incident NPC cases and 745 subcohort participants. A multiplex serology assay was used to quantify IgA and IgG antibodies against 16 EBV antigens in stored baseline plasma samples. Cox regression was used to estimate adjusted hazard ratios (HRs) for NPC and C-statistics to assess the discriminatory ability of EBV-markers, including two previously identified EBV-marker combinations, for predicting NPC. Results Sero-positivity for 15 out of 16 EBV-markers was significantly associated with higher NPC risk. Both IgA and IgG antibodies against the same three EBV-markers showed the most extreme HRs, i.e. BGLF2 (IgA: 124.2 (95% CI: 63.3–243.9); IgG: 8.6 (5.5–13.5); LF2: [67.8 (30.0–153.1), 10.9 (7.2–16.4)]); and BFRF1: 26.1 (10.1–67.5), 6.1 (2.7–13.6). Use of a two-marker (i.e. LF2/BGLF2 IgG) and a four-marker (i.e. LF2/BGLF2 IgG and LF2/EA-D IgA) combinations yielded C-statistics of 0.85 and 0.84, respectively, which persisted for at least 5 years after sample collection in both endemic and non-endemic areas. Conclusions In Chinese adults, plasma EBV markers strongly predict NPC occurrence many years before clinical diagnosis. LF2 and BGLF2 IgG could identify NPC high-risk individuals to improve NPC early detection in community and clinical settings. [ABSTRACT FROM AUTHOR]

Published
2024
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161. Dietary factors and patterns in relation to risk of later‐onset ulcerative colitis in Chinese: A prospective study of 0.5 million people.

Author

Song, Shuyao, Wu, Zhiyu, Lv, Jun, Yu, Canqing, Sun, Dianjianyi, Pei, Pei, Pan, Lang, Yang, Ling, Chen, Yiping, Du, Huaidong, Chen, Lingli, Schmidt, Dan, Avery, Daniel, Duan, Liping, Chen, Junshi, Chen, Zhengming, Li, Liming, and Pang, Yuanjie

Subjects
DIETARY patterns, ULCERATIVE colitis, PRINCIPAL components analysis, FOOD habits, LONGITUDINAL method, FOOD of animal origin
Abstract

Summary: Background: There is limited evidence on the associations of dietary factors and patterns with risk of later‐onset ulcerative colitis (UC) in Chinese adults. Aims: To investigate the associations of dietary factors and patterns with risk of later‐onset UC in Chinese. Methods: The prospective China Kadoorie Biobank cohort study recruited 512,726 participants aged 30–79. Dietary habits were assessed using food frequency questionnaires. Dietary patterns were derived by factor analysis with a principal component method. Cox regression analysis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During a median follow‐up of 12.1 years, 312 cases of newly diagnosed UC were documented (median age of diagnosis 60.1 years). Egg consumption was associated with higher risk of UC (HR for daily vs. never or rarely: 2.29 [95% CI: 1.26–4.16]), while spicy food consumption was inversely associated with risk of UC (HR: 0.63 [0.45–0.88]). The traditional northern dietary pattern, characterised by high intake of wheat and low intake of rice, was associated with higher risk of UC (HR for highest vs. lowest quartile of score: 2.79 [1.93–4.05]). The modern dietary pattern, characterised by high intake of animal‐origin foods and fruits, was associated with higher risk of UC (HR: 2.48 [1.63–3.78]). Population attributable fraction was 13.04% (7.71%–19.11%) for daily/almost daily consumption of eggs and 9.87% (1.94%–18.22%) for never/rarely consumption of spicy food. Conclusions: The findings highlight the importance of evaluating dietary factors and patterns in the primary prevention of later‐onset UC in Chinese adults. [ABSTRACT FROM AUTHOR]

Published
2024
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163. Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie

Published
2022
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165. Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study

Author

Wang, Chen, He, Jiang, Xu, Jianying, Yang, Lan, Xu, Yongjian, Zhang, Xiangyan, Bai, Chenxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Yao, Wanzhen, Shan, Guangliang, Yang, Ting, Lin, Yingxiang, Wu, Sinan, Zhu, Jianguo, Wang, Ruiying, Shi, Zhihong, Zhao, Jianping, Ye, Xianwei, Song, Yuanlin, Yang, Dong, Wang, Qiuyue, Hou, Gang, Zhou, Yumin, Li, Wen, Ding, Liren, Wan, Chun, Wang, Hao, Chen, Yahong, Guo, Yanfei, Xiao, Fei, Lu, Yong, Peng, Xiaoxia, Zhang, Biao, Xiao, Dan, Wang, Zuomin, Bu, Xiaoning, Zhang, Hong, Zhang, Xiaolei, An, Li, Zhang, Shu, Cao, Zhixin, Zhan, Qingyuan, Yang, Yuanhua, Cao, Bin, Dai, Huaping, Liang, Lirong, Wang, Chaolong, Tong, Xunliang, Wu, Tangchun, Kan, Haidong, Chen, Renjie, Cai, Hua, Xiong, Weining, Zhang, Pengjun, Li, Yong, Niu, Wenquan, Chen, Chung-Shiuan, Xu, Guodong, Zhang, Xinran, Gu, Xiaoying, Dong, Fen, Liu, Zhao, Cheng, Anqi, Pei, Zhengcun, Niu, Hongtao, Huang, Ke, Chen, Simiao, Chung, Kian Fan, Chen, Zhengming, Bai, Chunxue, and Sun, Tieying

Published
2020
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166. Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance)

Author

Bueno, Raphael, Richards, William G., Harpole, David H., Ballman, Karla V., Tsao, Ming-Sound, Chen, Zhengming, Wang, Xiaofei, Chen, Guoan, Chirieac, Lucian R., Chui, M. Herman, Franklin, Wilbur A., Giordano, Thomas J., Govindan, Ramaswamy, Joshi, Mary-Beth, Merrick, Daniel T., Rivard, Christopher J., Sporn, Thomas, van Bokhoven, Adrie, Yu, Hui, Shepherd, Frances A., Watson, Mark A., Beer, David G., and Hirsch, Fred R.

Published
2020
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167. Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study

Author

Jin, Guangfu, Lv, Jun, Yang, Ming, Wang, Mengyun, Zhu, Meng, Wang, Tianpei, Yan, Caiwang, Yu, Canqing, Ding, Yanbing, Li, Gang, Ren, Chuanli, Ni, Jing, Zhang, Ruoxin, Guo, Yu, Bian, Zheng, Zheng, Yan, Zhang, Nasha, Jiang, Yue, Chen, Jiaping, Wang, Yanong, Xu, Dazhi, Zheng, Hong, Yang, Ling, Chen, Yiping, Walters, Robin, Millwood, Iona Y, Dai, Juncheng, Ma, Hongxia, Chen, Kexin, Chen, Zhengming, Hu, Zhibin, Wei, Qingyi, Shen, Hongbing, and Li, Liming

Published
2020
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171. Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults

Author

Chen, Yiping, Wright, Neil, Guo, Yu, Turnbull, Iain, Kartsonaki, Christiana, Yang, Ling, Bian, Zheng, Pei, Pei, Pan, Dongxia, Zhang, Yidan, Qin, Haiqiang, Wang, Yilong, Lv, Jun, Liu, Ming, Hao, Zilong, Wang, Yongjun, Yu, Canqing, Peto, Richard, Collins, Rory, Li, Liming, Clarke, Robert, Chen, Zhengming, Chen, Junshi, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Kerosi, Rene, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sohoni, Rajani, Wang, Jenny, Wang, Lin, Yang, Xiaoming, Han, Xiao, Hou, Can, Jing, Biao, Liu, Chao, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, and Qiu, Zhe

Published
2020
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173. Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Yu, Kuai, Qiu, Gaokun, Wang, Chaolong, Pan, An, Liang, Liming, Hu, Frank B, and Wu, Tangchun

Published
2020
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177. Impact of Graft Source on Transplant Outcomes in Myelofibrosis

Author

Ghalehsari, Nima, primary, Chen, Zhengming, additional, Mayer, Sebastian, additional, Abu-Zeinah, Ghaith, additional, Shore, Tsiporah B., additional, Ritchie, Ellen K., additional, Silver, Richard, additional, Schafer, Andrew I, additional, Scandura, Joseph M, additional, Roboz, Gail J., additional, van Besien, Koen, additional, and Gomez, Alexandra, additional

Published
2024
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178. A Prospective Study of Tocilizumab for the Prevention of Graft Failure and Graft-Versus-Host Disease in Haplo-Cord Transplantation, As a Potential Alternative to Anti-Thymocyte Globulin

Author

Orfali, Nina, primary, Alhomoud, Mohammad, additional, Contreras, Jorge, additional, Chen, Zhengming, additional, Ballman, Karla V, additional, Mayer, Sebastian, additional, Hsu, Jingmei, additional, Cushing, Melissa, additional, Pasciolla, Michelle S, additional, Phillips, Adrienne A, additional, Chaekal, Ok-Kyong, additional, Boelens, Jaap-Jan, additional, Guzman, Monica L, additional, Shore, Tsiporah B., additional, van Besien, Koen, additional, and Gomez-Arteaga, Alexandra, additional

Published
2024
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179. Safety and Efficacy of Bridging Radiation Therapy in the Context of CD19 CART Therapy for Non-Hodgkin Lymphoma: Systematic Review and Meta-Analysis

Author

Alhomoud, Mohammad, primary, Ibrahim, Rahma, additional, Chen, Zhengming, additional, Martinet, Jeremie, additional, Foley, Michelle, additional, Gomez-Arteaga, Alexandra, additional, Guzman, Monica L, additional, Pagnini, Paul, additional, van Besien, Koen, additional, Shore, Tsiporah B., additional, and Yamshon, Samuel, additional

Published
2024
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180. Methods and participant characteristics in the Cancer Risk in Vegetarians Consortium: A cross-sectional analysis across 11 prospective studies

Author

Dunneram, Yashvee, primary, Lee, Jia Yi, additional, Watling, Cody Z., additional, Fraser, Gary E, additional, Miles, Fayth, additional, Prabhakaran, Dorairaj, additional, Shridhar, Krithiga, additional, Kondal, Dimple, additional, Mohan, Viswanathan, additional, Ali, Mohammed K., additional, Venkat Narayan, Kabayam M., additional, Tandon, Nikhil, additional, Tong, Tammy Y. N., additional, Chiu, Tina H.T., additional, Lin, Ming-Nan, additional, Lin, Chin-Lon, additional, Yang, Hsin-Chou, additional, Liang, Yu-Jen, additional, Greenwood, Darren C., additional, Du, Huaidong, additional, Chen, Zhengming, additional, Yu, Canqing, additional, Kakkoura, Maria G., additional, Reeves, Gillian K., additional, Papier, Keren, additional, Floud, Sarah, additional, Sinha, Rashmi, additional, Liao, Linda M., additional, Loftfield, Erikka, additional, Cade, Janet E., additional, Key, Timothy J., additional, and Perez-Cornago, Aurora, additional

Published
2024
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182. Data from XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells

Author

Marullo, Rossella, primary, Rutherford, Sarah C., primary, Revuelta, Maria V., primary, Zamponi, Nahuel, primary, Culjkovic-Kraljacic, Biljana, primary, Kotlov, Nikita, primary, Di Siervi, Nicolás, primary, Lara-Garcia, Juan, primary, Allan, John N., primary, Ruan, Jia, primary, Furman, Richard R., primary, Chen, Zhengming, primary, Shore, Tsiporah B., primary, Phillips, Adrienne A., primary, Mayer, Sebastian, primary, Hsu, Jingmei, primary, van Besien, Koen, primary, Leonard, John P., primary, Borden, Katherine L.B., primary, Inghirami, Giorgio, primary, Martin, Peter, primary, and Cerchietti, Leandro, primary

Published
2024
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183. Supplementary Data from XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells

Author

Marullo, Rossella, primary, Rutherford, Sarah C., primary, Revuelta, Maria V., primary, Zamponi, Nahuel, primary, Culjkovic-Kraljacic, Biljana, primary, Kotlov, Nikita, primary, Di Siervi, Nicolás, primary, Lara-Garcia, Juan, primary, Allan, John N., primary, Ruan, Jia, primary, Furman, Richard R., primary, Chen, Zhengming, primary, Shore, Tsiporah B., primary, Phillips, Adrienne A., primary, Mayer, Sebastian, primary, Hsu, Jingmei, primary, van Besien, Koen, primary, Leonard, John P., primary, Borden, Katherine L.B., primary, Inghirami, Giorgio, primary, Martin, Peter, primary, and Cerchietti, Leandro, primary

Published
2024
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184. Supplementary Table 1 from XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells

Author

Marullo, Rossella, primary, Rutherford, Sarah C., primary, Revuelta, Maria V., primary, Zamponi, Nahuel, primary, Culjkovic-Kraljacic, Biljana, primary, Kotlov, Nikita, primary, Di Siervi, Nicolás, primary, Lara-Garcia, Juan, primary, Allan, John N., primary, Ruan, Jia, primary, Furman, Richard R., primary, Chen, Zhengming, primary, Shore, Tsiporah B., primary, Phillips, Adrienne A., primary, Mayer, Sebastian, primary, Hsu, Jingmei, primary, van Besien, Koen, primary, Leonard, John P., primary, Borden, Katherine L.B., primary, Inghirami, Giorgio, primary, Martin, Peter, primary, and Cerchietti, Leandro, primary

Published
2024
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187. Diabetes and chronic kidney disease in Chinese adults: a population-based cohort study

Author

Wang, Xue, primary, Chen, Lu, additional, Shi, Kexiang, additional, Lv, Jun, additional, Sun, Dianjianyi, additional, Pei, Pei, additional, Yang, Ling, additional, Chen, Yiping, additional, Du, Huaidong, additional, Liu, Jiaqiu, additional, Yang, Xiaoming, additional, Barnard, Maxim, additional, Chen, Junshi, additional, Chen, Zhengming, additional, Li, Liming, additional, and Yu, Canqing, additional

Published
2024
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188. Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation

Author

Rivas, Martín A., Meydan, Cem, Chin, Christopher R., Challman, Matt F., Kim, Daleum, Bhinder, Bhavneet, Kloetgen, Andreas, Viny, Aaron D., Teater, Matt R., McNally, Dylan R., Doane, Ashley S., Béguelin, Wendy, Fernández, María Teresa Calvo, Shen, Hao, Wang, Xiang, Levine, Ross L., Chen, Zhengming, Tsirigos, Aristotelis, Elemento, Olivier, Mason, Christopher E., and Melnick, Ari M.

Published
2021
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189. Associations of diabetes, circulating protein biomarkers, and risk of pancreatic cancer

Author

Pang, Yuanjie, primary, Lv, Jun, additional, Wu, Ting, additional, Yu, Canqing, additional, Guo, Yu, additional, Chen, Yiping, additional, Yang, Ling, additional, Millwood, Iona Y., additional, Walters, Robin G., additional, Yang, Xiaoming, additional, Stevens, Rebecca, additional, Clarke, Robert, additional, Chen, Junshi, additional, Li, Liming, additional, Chen, Zhengming, additional, and Kartsonaki, Christiana, additional

Published
2023
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190. Infectious pathogens and risk of esophageal, gastric and duodenal cancers and ulcers in China: A case‐cohort study

Author

Kartsonaki, Christiana, primary, Yao, Pang, additional, Butt, Julia, additional, Jeske, Rima, additional, de Martel, Catherine, additional, Plummer, Martyn, additional, Sun, Dianjianyi, additional, Clark, Sarah, additional, Walters, Robin G., additional, Chen, Yiping, additional, Lv, Jun, additional, Yu, Canqing, additional, Hill, Michael, additional, Peto, Richard, additional, Li, Liming, additional, Waterboer, Tim, additional, Chen, Zhengming, additional, Millwood, Iona Y., additional, and Yang, Ling, additional

Published
2023
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191. A background parenchymal enhancement quantification framework of breast magnetic resonance imaging

Author

Zhang, Boya, primary, Zhu, Jingjin, additional, Zhang, Peifang, additional, Wei, Yufan, additional, Li, Yan, additional, Xu, Aoxi, additional, Zhang, Yiheng, additional, Zheng, Hongye, additional, Dong, Xiaohan, additional, Yang, Kaizhou, additional, Dong, Chuang, additional, Chen, Zhengming, additional, Li, Xiru, additional, and Cheng, Liuquan, additional

Published
2023
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193. Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

Author

Lu, Tianyuan, Forgetta, Vincenzo, Keller-Baruch, Julyan, Nethander, Maria, Bennett, Derrick, Forest, Marie, Bhatnagar, Sahir, Walters, Robin G., Lin, Kuang, Chen, Zhengming, Li, Liming, Karlsson, Magnus, Mellström, Dan, Orwoll, Eric, McCloskey, Eugene V., Kanis, John A., Leslie, William D., Clarke, Robert J., Ohlsson, Claes, Greenwood, Celia M. T., and Richards, J. Brent

Published
2021
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199. Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations

Author

Dai, Juncheng, Lv, Jun, Zhu, Meng, Wang, Yuzhuo, Qin, Na, Ma, Hongxia, He, Yong-Qiao, Zhang, Ruoxin, Tan, Wen, Fan, Jingyi, Wang, Tianpei, Zheng, Hong, Sun, Qi, Wang, Lijuan, Huang, Mingtao, Ge, Zijun, Yu, Canqing, Guo, Yu, Wang, Tong-Min, Wang, Jie, Xu, Lin, Wu, Weibing, Chen, Liang, Bian, Zheng, Walters, Robin, Millwood, Iona Y, Li, Xi-Zhao, Wang, Xin, Hung, Rayjean J, Christiani, David C, Chen, Haiquan, Wang, Mengyun, Wang, Cheng, Jiang, Yue, Chen, Kexin, Chen, Zhengming, Jin, Guangfu, Wu, Tangchun, Lin, Dongxin, Hu, Zhibin, Amos, Christopher I, Wu, Chen, Wei, Qingyi, Jia, Wei-Hua, Li, Liming, and Shen, Hongbing

Published
2019
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