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156. The decreasion of integrin α5β1/FAK associates with increased apoptosis of aortic smooth muscle cells in acute type A aortic dissection

Author

Xue, Mingming, primary, Yang, Yilin, additional, Xing, Lingyu, additional, Liao, Fengqing, additional, Xu, Feixiang, additional, Chen, Yumei, additional, Wang, Sheng, additional, Chen, Bin, additional, Yao, Chenling, additional, Gu, Guorong, additional, Tong, Chaoyang, additional, and Shao, Mian, additional

Published
2023
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157. Table S6 from A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms

Author

Shen, Qiujin, primary, Feng, Yahui, primary, Gong, Xiaowen, primary, Jia, Yujiao, primary, Gao, Qingyan, primary, Jiao, Xiaokang, primary, Qi, Saibing, primary, Liu, Xueou, primary, Wei, Hui, primary, Huang, Bingqing, primary, Zhao, Ningning, primary, Song, Xiaoqiang, primary, Ma, Yueshen, primary, Liang, Shihao, primary, Zhang, Donglei, primary, Qin, Li, primary, Wang, Ying, primary, Qu, Shiqiang, primary, Zou, Yao, primary, Chen, Yumei, primary, Guo, Ye, primary, Yi, Shuhua, primary, An, Gang, primary, Jiao, Zengtao, primary, Zhang, Song, primary, Li, Linfeng, primary, Yan, Jun, primary, Wang, Huijun, primary, Song, Zhen, primary, Mi, Yingchang, primary, Qiu, Lugui, primary, Zhu, Xiaofan, primary, Wang, Jianxiang, primary, Xiao, Zhijian, primary, and Chen, Junren, primary

Published
2023
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158. Data from A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms

Author

Shen, Qiujin, primary, Feng, Yahui, primary, Gong, Xiaowen, primary, Jia, Yujiao, primary, Gao, Qingyan, primary, Jiao, Xiaokang, primary, Qi, Saibing, primary, Liu, Xueou, primary, Wei, Hui, primary, Huang, Bingqing, primary, Zhao, Ningning, primary, Song, Xiaoqiang, primary, Ma, Yueshen, primary, Liang, Shihao, primary, Zhang, Donglei, primary, Qin, Li, primary, Wang, Ying, primary, Qu, Shiqiang, primary, Zou, Yao, primary, Chen, Yumei, primary, Guo, Ye, primary, Yi, Shuhua, primary, An, Gang, primary, Jiao, Zengtao, primary, Zhang, Song, primary, Li, Linfeng, primary, Yan, Jun, primary, Wang, Huijun, primary, Song, Zhen, primary, Mi, Yingchang, primary, Qiu, Lugui, primary, Zhu, Xiaofan, primary, Wang, Jianxiang, primary, Xiao, Zhijian, primary, and Chen, Junren, primary

Published
2023
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159. Figures S1-S6, Tables S8-S10 from A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms

Author

Shen, Qiujin, primary, Feng, Yahui, primary, Gong, Xiaowen, primary, Jia, Yujiao, primary, Gao, Qingyan, primary, Jiao, Xiaokang, primary, Qi, Saibing, primary, Liu, Xueou, primary, Wei, Hui, primary, Huang, Bingqing, primary, Zhao, Ningning, primary, Song, Xiaoqiang, primary, Ma, Yueshen, primary, Liang, Shihao, primary, Zhang, Donglei, primary, Qin, Li, primary, Wang, Ying, primary, Qu, Shiqiang, primary, Zou, Yao, primary, Chen, Yumei, primary, Guo, Ye, primary, Yi, Shuhua, primary, An, Gang, primary, Jiao, Zengtao, primary, Zhang, Song, primary, Li, Linfeng, primary, Yan, Jun, primary, Wang, Huijun, primary, Song, Zhen, primary, Mi, Yingchang, primary, Qiu, Lugui, primary, Zhu, Xiaofan, primary, Wang, Jianxiang, primary, Xiao, Zhijian, primary, and Chen, Junren, primary

Published
2023
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164. 5G-Based Remote Virtual Bronchoscopic Navigation-Guided Transbronchial Lung Biopsy for Diagnosis of Lung Cancer: Description of 2 Cases.

Author

Huang, Junfeng, Lin, Jinsheng, Chen, Chongxiang, Liang, Weiquan, Chen, Yumei, Li, Hongjia, Zhong, Changhao, and Li, Shiyue

Subjects
BIOPSY, WIRELESS communications, ULTRASONIC imaging, LUNGS, LUNG tumors, BRONCHOSCOPY, TELEMEDICINE
Abstract

Introduction: Bronchoscopic navigation combined with endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) is an important approach for the diagnosis of peripheral pulmonary lesions (PPL). The fifth-generation (5G) network, characterized by low latency and high stability, has shown promising possibilities in telemedicine for remote areas. Methods: We present two cases of PPL in primary hospitals without navigation equipment. The EBUS-TBLB was performed with the guidance of remote augmented reality virtual bronchoscopic navigation (VBN) based on a 5G network. In practice, the 5G network could enable the matching of actual/virtual bronchoscopic images and navigation paths in real time, as well as high-speed transmission at long distances (>20 km), without any visual delay (<500 ms). Conclusion: Both patients were successfully diagnosed with lung cancer after accurate positioning and obtaining biopsies of target lesions. This 5G-based remote VBN-guided EBUS-TBLB appears to be safe with reliable connections in both cases and shows potential for cost-effectiveness. It would be an optimal resource for undeveloped regions and/or regions lacking endoscopists with extensive experience in navigation-related procedures. [ABSTRACT FROM AUTHOR]

Published
2023
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165. Improved accuracy of the biodistribution and internal radiation dosimetry of 13N‐ammonia using a total‐body PET/CT scanner.

Author

Yu, Xiaofeng, Sun, Hongyan, Xu, Lian, Han, Yuan, Wang, Cheng, Li, Lianghua, Ng, Yee Ling, Shi, Fuxiao, Qiu, Ju, Huang, Gang, Zhou, Yun, Chen, Yumei, and Liu, Jianjun

Subjects
RADIATION dosimetry, ORGANS (Anatomy), ABSORBED dose, BLADDER, SCANNING systems, RADIATION doses
Abstract

Background: Conventional short‐axis PET typically utilizes multi‐bed multi‐pass acquisition to produce quantitative whole‐body dynamic images and cannot record all the uptake information simultaneously, resulting in errors when fitting the time‐activity curves (TACs) and calculating radiation doses. Purpose: The aim of this study is to evaluate the 13N‐ammonia biodistribution and the internal radiation doses using a 194 cm long total‐body PET/CT scanner (uEXPLORER), and make a comparison with the previous short‐axis PET results. Methods: Ten subjects (age 40–74 years) received 13N‐NH3 injection (418.1‐670.81 MBq) and were under a dynamic scan for about 60 min with using a 3‐dimensional whole‐body protocol. ROIs were drawn visually on 11 major organs (brain, thyroid, gallbladder, heart wall, kidneys, liver, pancreas, spleen, lungs, bone marrow, and urinary bladder content) for each subject. TACs were generated using Pmod and the absorbed radiation doses were calculated using Olinda 2.2. To compare with the conventional PET/CT, five points were sampled on uEXPLORER's TACs to mimic the result of a short‐axis PET/CT (15 cm axial FOV, consisted of 9 or 10 bed positions). Then the TACs were obtained using the multi‐exponential fitting method, and the residence time and radiation dose were also calculated and compared with uEXPLORER. Results: The highest absorbed organ doses were the pancreas, thyroid, spleen, heart wall, and kidneys for the male. For the female, the first five highest absorbed organ dose coefficients were the pancreas, heart wall, spleen, lungs, and kidneys. The lowest absorbed dose was found in red marrow both for male and female. The simulated short‐axis PET can fit TACs well for the gradually‐changed uptake organs but typically underestimated for the rapid‐uptake organs during the first‐10 min, resulting in errors in the calculated radiation dose. Conclusion: uEXPLORER PET/CT can measure 13N‐ammonia's TACs simultaneously in all organs of the whole body, which can provide more accurate biodistribution and radiation dose estimation compared with the conventional short‐axis scanners. [ABSTRACT FROM AUTHOR]

Published
2023
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166. Relationship between the expression of PD-L1 and 18F-FDG uptake in pancreatic ductal adenocarcinoma.

Author

Li, Jiajin, Chen, Ruohua, Chen, Yumei, Xia, Qing, Zhou, Xiang, Xia, Qian, wang, Cheng, Wan, Liangrong, Bao, Haiqin, Huang, Gang, and Liu, Jianjun

Abstract

Background: PD-L1 promotes glycolysis in tumour cells. We observed a correlation between high PD-L1 expression and high 18F-FDG uptake in patients with pancreatic ductal adenocarcinoma (PDAC) in a previous study. This study aims to determine the usefulness of 18F-FDG PET/CT for evaluating the PD-L1 status in PDAC and to elucidate its rationality by integrated analyses. Methods: For bioinformatics analysis, WGCNA, GSEA and TIMER were applied to analyse the pathways and hub genes associated with PD-L1 and glucose uptake. 18F-FDG uptake assay was used to determine the glucose uptake rate of PDAC cells in vitro. Related genes expression were verified by RT-PCR and western blot. A retrospective analysis was performed on 47 patients with PDAC who had undergone 18F-FDG PET/CT. Maximum standardised uptake values (SUVmax) were determined. The usefulness of SUVmax for evaluating PD-L1 status was determined by receiver operating characteristic (ROC) curve analysis. Results: Bioinformatics analysis showed that several signalling pathways are associated with both PD-L1 expression and tumour glucose uptake, among which JAK-STAT may be an important one. By in vitro experiments, the regulatory role of PD-L1 on glucose uptake was demonstrated, and its dependency on the JAK-STAT pathway was also verified by the rescue study. The SUVmax of PD-L1-positive patients was significantly higher than PD-L1-negative in tumour cells (TCs) (6.1 ± 2.3 vs. 11.1 ± 4.2; P < 0.001), and in tumour-infiltrating immune cells (TIICs) (6.4 ± 3.2 vs. 8.4 ± 3.5; P < 0.001). In a multivariate analysis, SUVmax was significantly associated with PD-L1 expression in TCs and TIICs (P < 0.001 and P = 0.018, respectively). Using SUVmax cut-off values of 8.15 and 7.75, PD-L1 status in TCs and TIICs could be predicted with accuracies of 91.5% and 74.5%, respectively. Conclusion: Higher 18F-FDG uptake by PDAC is associated with elevated PD-L1 expression. JAK-STAT is an important pathway that mediates PD-L1 to promote glucose uptake in PDAC. [ABSTRACT FROM AUTHOR]

Published
2023
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167. First Total-Body Kinetic Modeling and Parametric Imaging of Dynamic68Ga-FAPI-04 PET in Pancreatic and Gastric Cancer

Author

Chen, Ruohua, primary, Yang, Xinlan, additional, Ng, Yee Ling, additional, Yu, Xiaofeng, additional, Huo, Yanmiao, additional, Xiao, Xiuying, additional, Zhang, Chenpeng, additional, Chen, Yumei, additional, Zheng, Chaojie, additional, Li, Lianghua, additional, Huang, Gang, additional, Zhou, Yun, additional, and Liu, Jianjun, additional

Published
2023
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169. Phenotypic and genotypic correlation evaluation of 148 pediatric patients with Fanconi anemia in a Chinese rare disease cohort

Author

Chang, Lixian, primary, Zhang, Li, additional, An, Wenbin, additional, Wan, Yang, additional, Cai, Yuli, additional, Lan, Yang, additional, Zhang, Aoli, additional, Liu, Lipeng, additional, Ruan, Min, additional, Liu, Xiaoming, additional, Guo, Ye, additional, Yang, Wenyu, additional, Chen, Xiaojuan, additional, Chen, Yumei, additional, Wang, Shuchun, additional, Zou, Yao, additional, Yuan, Weiping, additional, and Zhu, Xiaofan, additional

Published
2023
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172. A deep learning model for the differential diagnosis of benign and malignant salivary gland tumors based on ultrasound imaging and clinical data

Author

Zhang, Gang, primary, Zhu, Li, additional, Huang, Rong, additional, Xu, Yushan, additional, Lu, Xiaokai, additional, Chen, Yumei, additional, Li, Chen, additional, Lei, Yujie, additional, Luo, Xiaomao, additional, Li, Zhiyao, additional, Yi, Sanli, additional, He, Jianfeng, additional, and Zheng, Chenhong, additional

Published
2023
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174. Electrochemical immunosensor for ultrasensitive detection of human papillomaviruse type 16 L1 protein based on Ag@AuNPs-GO/SPA

Author

Wang, Aiping, primary, Zhou, Yiting, additional, Chen, Yumei, additional, Zhou, Jingming, additional, You, Xiaojuan, additional, Liu, Hongliang, additional, Liu, Yankai, additional, Ding, Peiyang, additional, Qi, Yanhua, additional, Liang, Chao, additional, Zhu, Xifang, additional, Zhang, Ying, additional, Liu, Enping, additional, and Zhang, Gaiping, additional

Published
2023
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175. The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

Author

Ding, Ding, primary, Zhao, Haitao, additional, Wei, Dali, additional, Yang, Qinglai, additional, Yang, Cai, additional, Wang, Ruowen, additional, Chen, Yumei, additional, Li, Lianghua, additional, An, Shuxian, additional, Xia, Qian, additional, Huang, Gang, additional, Liu, Jianjun, additional, Xiao, Zeyu, additional, and Tan, Weihong, additional

Published
2023
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177. The Elevation of Red Blood Cell Distribution Width is an Independent Prognostic Factor for Juvenile Myelomonocytic Leukemia

Author

Liang, Weiru, primary, Liu, Chenmeng, additional, Zhang, Jingliao, additional, Yi, Meihui, additional, Cai, Yuli, additional, Zhang, Aoli, additional, Liu, Lipeng, additional, Zhang, Li, additional, Chen, Xiaojuan, additional, Zou, Yao, additional, Chen, Yumei, additional, Guo, Ye, additional, Zhang, Yingchi, additional, Zhu, Xiaofan, additional, and Yang, Wenyu, additional

Published
2022
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179. Serological survey of SARS-CoV-2 in companion animals in China

Author

Wang, Aiping, primary, Zhu, Xifang, additional, Chen, Yumei, additional, Sun, Yaning, additional, Liu, Hongliang, additional, Ding, Peiyang, additional, Zhou, Jingming, additional, Liu, Yankai, additional, Liang, Chao, additional, Yin, Jiajia, additional, and Zhang, Gaiping, additional

Published
2022
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180. Electrochemical immunosensor nanoarchitectonics with the Ag-rGO nanocomposites for the detection of receptor-binding domain of SARS-CoV-2 spike protein

Author

Wang, Aiping, primary, Li, Yuya, additional, You, Xiaojuan, additional, Zhang, Shoutao, additional, Zhou, Jingming, additional, Liu, Hongliang, additional, Ding, Peiyang, additional, Chen, Yumei, additional, Qi, Yanhua, additional, Liu, Yankai, additional, Liang, Chao, additional, Zhu, Xifang, additional, Zhang, Ying, additional, Liu, Enping, additional, and Zhang, Gaiping, additional

Published
2022
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184. Short-Term Follow-up of Blinatumomab in Children with B-Cell Precursor Acute Lymphoblastic Leukemia：Study of a Single Center from China

Author

Yang, Wenyu, primary, Li, Xiaolan, additional, Liu, Li-Peng, additional, Wan, Yang, additional, Liu, Tianfeng, additional, Zhao, Bei-bei, additional, Ruan, Min, additional, Qi, Benquan, additional, Chen, Xia, additional, Liu, Fang, additional, Ren, Yuanyuan, additional, Zhang, Li, additional, Zou, Yao, additional, Chen, Yumei, additional, Chen, Xiaojuan, additional, Guo, Ye, additional, and Zhu, Xiaofan, additional

Published
2022
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185. Clinical Feature and Effect of Demethylation Therapy in Pediatric Patients with Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Author

Wan, Yang, primary, Zhang, Ranran, additional, Ruan, Min, additional, Li, Jun, additional, Li, Xiaolan, additional, Zhang, Xiaoyan, additional, Chen, Xiaojuan, additional, Zhang, Li, additional, Zou, Yao, additional, Chen, Yumei, additional, Guo, Ye, additional, Yang, Wenyu, additional, and Zhu, Xiaofan, additional

Published
2022
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186. Synthesis, crystal structure and DFT study of tert-butyl 4-(5-bromopyridin-2-yloxy)piperidine-1-carboxylate

Author

Hou, Yuanyuan, Wu, Qingmei, Chen, Yumei, Ye, Wenjun, Wang, Sisi, Zhao, Chunshen, and Zhou, Zhixu

Abstract

In this study, tert-butyl 4-(5-bromopyridin-2-yloxy)piperidine-1-carboxylate was synthesized. The title compound was characterized using 1H NMR, 13C NMR, MS, and FT-IR techniques, and its single crystal was evaluated using X-ray diffraction (XRD). The molecular structure was optimized using the density functional theory (DFT) at the B3LYP/6-311 + G(2d, p) level. The optimized structure was also compared with the crystal structure determined using single-crystal (XRD), and the results were consistent. Molecular electrostatic potential (MEP) and frontier molecular orbital (FMOs) analyses of the title compound were preformed using computational methods. Infrared vibrational analysis of the target compound was also conducted.

Published
2023
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187. Additional file 1 of Egfr signaling promotes juvenile hormone biosynthesis in the German cockroach

Author

Li, Zhaoxin, Zhou, Caisheng, Chen, Yumei, Ma, Wentao, Cheng, Yunlong, Chen, Jinxin, Bai, Yu, Luo, Wei, Li, Na, Du, Erxia, and Li, Sheng

Abstract

Additional file 1: Figure S1. Effect of RNAi each Egf ligand gene on Jhamt and Cyp15A1 expression. Figure S2. Effect of RNAi pairwise combinations of the three Egf ligand genes Jhamt and Cyp15A1 expression. Figure S3. Expression patterns of Egfr, spi, vn, Jhamt and Cyp15A1 of adult females, during the first vitellogenic cycle. Figure S4. Compare Egfr RNAi with InR RNAi. Figure S5. RNAi Egfr at the nymph stage. Figure S6. Egf ligands and Pnt RNAi at the nymph stage. Figure S7. Specificity verification of anti-JHAMT. Table S1. Primers used for qPCR, RNAi and 5′-RACE.

Published
2023
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193. A comprehensive investigation discovered the novel methyltransferase METTL24 as one presumably prognostic gene for kidney renal clear cell carcinoma potentially modulating tumor immune microenvironment

Author

Jiang, Zhongji, primary, Zhang, Wei, additional, Zeng, Zhipeng, additional, Tang, Donge, additional, Li, Chujiao, additional, Cai, Wanxia, additional, Chen, Yumei, additional, Li, Ya, additional, Jin, Qiu, additional, Zhang, Xinzhou, additional, Yin, Lianghong, additional, Liu, Xueyan, additional, Xu, Yong, additional, and Dai, Yong, additional

Published
2022
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194. Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus

Author

He, Jingquan, primary, Ma, Chiyu, additional, Tang, Donge, additional, Zhong, Shaoyun, additional, Yuan, Xiaofang, additional, Zheng, Fengping, additional, Zeng, Zhipeng, additional, Chen, Yumei, additional, Liu, Dongzhou, additional, Hong, Xiaoping, additional, Dai, Weier, additional, Yin, Lianghong, additional, and Dai, Yong, additional

Published
2022
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195. Pediatric non–Down’s syndrome acute megakaryoblastic leukemia patients in China: A single center's real-world analysis

Author

Zhang, Aoli, primary, Liu, Lipeng, additional, Zong, Suyu, additional, Chen, Xiaoyan, additional, Liu, Chao, additional, Chang, Lixian, additional, Chen, Xiaojuan, additional, Yang, Wenyu, additional, Guo, Ye, additional, Zhang, Li, additional, Zou, Yao, additional, Chen, Yumei, additional, Zhang, Yingchi, additional, Ruan, Min, additional, and Zhu, Xiaofan, additional

Published
2022
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196. Integrated computer analysis and a self-built Chinese cohort study identified GSTM2 as one survival-relevant gene in human colon cancer potentially regulating immune microenvironment

Author

Zhang, Wei, primary, Shi, Yutong, additional, Niu, Shumeng, additional, Li, Lintai, additional, Lin, Liewen, additional, Gao, Xucan, additional, Cai, Wanxia, additional, Chen, Yumei, additional, Zhong, Yafang, additional, Tang, Donge, additional, Tang, Min, additional, and Dai, Yong, additional

Published
2022
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197. Short-term efficacy of decitabine-based therapy in JMML: a retrospective study from a single center in China

Author

Cai, Yuli, primary, Zhang, Jingliao, additional, Yi, Meihui, additional, Zhang, Wenfeng, additional, Liu, Xiaoming, additional, Zhang, Xiaoyan, additional, Wan, Yang, additional, Chang, Lixian, additional, Zhang, Li, additional, Chen, Xiaojuan, additional, Guo, Ye, additional, Zou, Yao, additional, Chen, Yumei, additional, Li, Jun, additional, Zhang, Yingchi, additional, Yang, Wenyu, additional, and Zhu, Xiaofan, additional

Published
2022
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200. Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy

Author

Yu, Tingdong, primary, He, Yanan, additional, Chen, Haitao, additional, Lu, Xiaokai, additional, Ni, Huijing, additional, Ma, Yimin, additional, Chen, Yumei, additional, Li, Chen, additional, Cao, Run, additional, Ma, Liju, additional, Li, zhiyao, additional, Lei, Yujie, additional, Luo, Xiaomao, additional, and Zheng, Chenhong, additional

Published
2022
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