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1,173 results on '"Chen, Xiaochun"'

152. The level of antimicrobial peptides in gingival crevicular fluid and its correlation with periodontal clinical indexes in elderly patients with type 2 diabetic periodontitis

Author

ZHANG Yameng, ZHANG Huiyuan, RUAN Shihong, CHEN Xiaochun, GAN Xueqi, and YU Haiyang

Subjects
antimicrobial peptides, gingival crevicular fluid, probing depth, probing bleeding, type 2 diabetes mellitus, Medicine, ll-37, middle-aged and elderly, periodontitis, attachment level, human beta defensins-2
Abstract

Objective To investigate the changes and significance of human beta-defensin-2 (HBD-2) and LL-37 in the gingival crevicular fluid of patients with periodontitis and type 2 diabetes mellitus (T2DM). Methods This study was conducted among 45- to 85-year-old patients in the Department of Stomatology and Internal Medicine of Shenzhen Center for Chronic Disease Control, including a healthy control group of 22 people, a systemically healthy control group of 19 people with periodontitis, a T2DM periodontal health group of 15 people, and a T2DM group of 21 people with periodontitis. The Florida periodontal probe was used for periodontal examination, and the clinical indexes, including probing depth (PD), clinical attachment level (CAL) and probing on bleeding (BOP), were recorded. The concentrations of HBD-2 and Ll-37 in gingival crevicular fluid were determined by ELISA. The differences in HBD-2, LL-37 and periodontal clinical indexes between the groups were compared, and correlation analysis was conducted.Results The PD values in T2DM with the periodontitis group were higher than those of the systemically healthy controls with periodontitis group (P < 0.05); the levels of HBD-2 and LL-37 in gingival crevicular fluid in systemically healthy controls with periodontitis group were significantly higher than those in the healthy control group (P < 0.05), the level of HBD-2 in gingival crevicular fluid in systemically healthy controls with periodontitis group was significantly higher than that in T2DM with periodontitis group (P < 0.05); and the antimicrobial peptides HBD-2 and LL-37 in gingival crevicular fluid were significantly positively correlated with the PD and CAL in systemically healthy controls with periodontitis group (P < 0.05), and there was no significant correlation between the antimicrobial peptides HBD-2, LL-37 in gingival crevicular fluid and PD, CAL in T2DM with periodontitis group (P > 0.05). Conclusion The levels of antimicrobial peptides HBD-2 and LL-37 in gingival crevicular fluid of middle-aged and elderly patients with T2DM periodontitis were lower, and there was no significant correlation with PD and CAL in periodontal clinical indicators.

Published
2021

153. The role of a key transcription factor PU.1 in autoimmune diseases

Author

Fang, Yilong, primary, Chen, Weile, additional, Li, Zhe, additional, Chen, Yu, additional, Wu, Xuming, additional, Zhu, Xiangling, additional, Wang, Huihui, additional, Chen, Xiaochun, additional, Liang, Qiuni, additional, Huang, Jinghua, additional, Han, Xintong, additional, Hong, Wenming, additional, Wang, Xinming, additional, Wei, Wei, additional, Yu, Zhiying, additional, and Tu, Jiajie, additional

Published
2022
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154. Hepatic Arterial Infusion Chemotherapy with Oxaliplatin Plus Raltitrexed as an Alternative Option in Advanced Hepatocellular Carcinoma Patients with Failure of, or Unsuitability for, Transarterial Chemoembolization

Author

Wu, Yanfang, primary, Zheng, Susu, additional, Zhang, Zhenzhen, additional, Chen, Guobin, additional, Chen, Xiaochun, additional, Zheng, Tanghui, additional, Guo, Xinkun, additional, Chen, Hong, additional, Wang, Meixia, additional, Xie, Xiaoying, additional, and Zhang, Boheng, additional

Published
2022
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164. Recurrence Outcome in Hepatocellular Carcinoma within Milan Criteria Undergoing Microwave Ablation with or without Transarterial Chemoembolization

Author

Chen, Guobin, primary, Chen, Hong, additional, Huang, Xing, additional, Cheng, Sisi, additional, Zheng, Susu, additional, Wu, Yanfang, additional, Zheng, Tanghui, additional, Chen, Xiaochun, additional, Guo, Xinkun, additional, Zhang, Zhenzhen, additional, Xie, Xiaoying, additional, and Zhang, Boheng, additional

Published
2022
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165. Immunoglobin G Sero-Dynamics Aided Host Specific Linear Epitope Identification and Differentiation of Infected from Vaccinated Hosts

Author

Chen, Xiaochun, primary, Li, Jingzhi, additional, Yang, Lan, additional, Zhou, Yuxi, additional, Li, Mengyu, additional, Xu, Wenwen, additional, Qin, Yixian, additional, Su, Jia, additional, Zhao, Wei, additional, Gu, Chaoyi, additional, Sheng, Shuixing, additional, Pan, Yongfei, additional, Xue, Qinghong, additional, and Ma, Hongwei, additional

Published
2022
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170. Vertical Seismic-Profile Data Local Full-Waveform Inversion Based on Marchenko Redatuming.

Author

Li, Kai, Huang, Xuri, Hu, Yezheng, Chen, Xiaochun, Chen, Kai, and Tang, Jing

Subjects
VERTICAL seismic profiling, GREEN'S functions, SEISMIC response
Abstract

Local full-waveform inversion (FWI) methods use redatumed seismic responses of virtual receivers within the subsurface to build the local objective function based on the convolution-type representation theorem. The Marchenko method is widely used to obtain the redatumed data. The method only requires a smoothed velocity model with correct kinematic characteristics of seismic responses for redatuming of the single-sided reflection data. However, the standard Marchenko method is insensitive to lateral propagation of the wavefield. By injecting the standard Marchenko redatumed wavefield along the boundary of the target, the local wavefield propagation modeling produces errors, which affects the accuracy of the local FWI. In this paper, a method to obtain more accurate Green's functions is proposed by incorporating vertical seismic profile data (VSP) into the calculation process of the Marchenko source-receiver redatuming. This method allows one to obtain the accurate laterally propagating waveform, resulting in a significant improvement of lateral resolution. The proposed method is applied to a benchmark model dataset and compared with the local FWI based on standard Marchenko redatuming. [ABSTRACT FROM AUTHOR]

Published
2023
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189. Effect of Genotype on the Pharmacokinetics and Bleeding Events of Direct Oral Anticoagulants: A Systematic Review and Meta‐analysis.

Author

Shi, Jinying, Wu, Tingting, Wu, Shuyi, Chen, Xiaochun, Ye, Qin, and Zhang, Jinhua

Subjects
ONLINE information services, MEDICAL databases, META-analysis, MEDICAL information storage & retrieval systems, SYSTEMATIC reviews, ANTICOAGULANTS, GENOTYPES, MEDLINE, HEMORRHAGE
Abstract

This meta‐analysis aimed to investigate the effect of the genotype on the pharmacokinetics and bleeding events of direct oral anticoagulants (DOACs) and comprehensively searched electronic databases. Weighted mean difference (WMD) was used to assess the kinetic indicators, odds ratio, and 95% confidence interval (CI) were used to calculate the clinical outcomes. Thirteen articles with 1543 participants were finally included in this study. The peak concentration (Cmax) and area under the plasma concentration–time curve from time 0 to infinity of individuals with the ABCB1 rs 1045642 CT + TT were higher than that of the CC (WMD = −31.9, 95% CI [−49.94, −12.24], P =.02; WMD = −79.97, 95%CI [−152.38 to −7.56], P =.03, I2 = 0). The Cmax of individuals with mutated genes in ABCB1 2677–3435 is higher than that the wild type (WMD = −19.20, 95%CI [36.62 to −1.79], P =.03, I2 = 0). Carriers of the CYP3A5 rs776746 GG genotype had a higher Cmax than the GA gene (WMD = −51.22, 95%CI [−92.26 to −10.19], P =.01, I2 = 0). Bleeding events were more common in the CES1 rs 2244613 AA + AC than in the CC (odds ratio, 2.62, 95%CI [1.06, 6.47], P =.04; I2 = 0). The Cmax of DOACs was affected by individuals with ABCB1 rs 1045642, ABCB1 2677‐343, and cytochrome P450 3A5 rs 776746. Carriers of the ABCB1 rs 1045642 affected the change of area under the plasma concentration–time curve from time 0 to infinity of DOACs. Bleeding events were affected by CES1 rs 2244613. [ABSTRACT FROM AUTHOR]

Published
2023
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190. Identifying critical success factors for the agri‐food cold chain's sustainable development: When the strategy system comes into play.

Author

Su, Miao, Woo, Su‐Han, Chen, Xiaochun, and Park, Keun‐sik

Subjects
CRITICAL success factor, BUSINESS planning, BUSINESS enterprises, ENVIRONMENTAL policy, STAKEHOLDER theory
Abstract

With serious environmental, cost, and social concerns arising from emerging countries' rapid growth in agricultural food cold chain (AFCC), AFCC firms urgently require a set of comprehensive sustainable strategic solutions. Therefore, this research identified and modeled the critical success factors (CSFs) that support the sustainable development of AFCCs. The study integrated institutional theory, stakeholder theory, and the triple bottom line model; it also surveyed cold chain experts from 16 different organizations in China and applied the adversarial interpretation structure model (AISM). This comprehensive analysis indicates that managing stakeholder pressure is the most motivating CSF of all strategies. This strategy eventually contributes to the sustainability of AFCC in China by driving other CSFs. Additionally, the study determined the degree of interdependence and dominance of different strategies. Thus, this study establishes a theoretical foundation for the sustainable improvement of AFCC organizations' business strategies and environmental policies. [ABSTRACT FROM AUTHOR]

Published
2023
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