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902 results on '"Chen, Luyao"'

161. Differentiation of cognate bacterial communities in thermokarst landscapes: implications for ecological consequences of permafrost degradation.

Author

Ren, Ze, Ye, Shudan, Li, Hongxuan, Huang, Xilei, and Chen, Luyao

Subjects
BACTERIAL communities, THERMOKARST, PERMAFROST, PERMAFROST ecosystems, LAKE sediments, LANDSCAPES
Abstract

Thermokarst processes likely result in new habitats harboring novel bacterial communities in degraded permafrost soil (PB), thermokarst lake sediments (SB), and lake water (WB). Our study aimed to investigate the paired PB, SB, and WB across the Qinghai–Tibet Plateau (QTP) by assessing the spatial pattern of diversity as well as assembly mechanisms of these bacterial communities. Each habitat had distinct bacterial assemblages, with lower α diversity and higher β diversity in WB than in SB and PB. However, up to 41 % of the operational taxonomic units (OTUs) were shared by PB, SB, and WB, suggesting that many taxa originate from the same sources via dispersal. SB and WB had reciprocal dispersal effects, and both were correlated with PB. Dispersal limitation was the most dominant assembly process shaping PB and SB, while homogeneous selection was the most dominant for WB. Bacterial communities of the three habitats correlated differently with environmental variables, but latitude, mean annual precipitation, and pH were the common factors associated with their β diversity, while total phosphorus was the common factor associated with their assembly processes. Our results imply that thermokarst processes result in diverse habitats that have distinct bacterial communities that differ in diversity, assembly mechanisms, and environmental drivers. [ABSTRACT FROM AUTHOR]

Published
2023
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167. MicrobeTCM: A Comprehensive Platform for the Interactions of Microbiota and Herbs

Author

Chen, Yufeng, primary, Zhang, Jiani, additional, Deng, Qiqi, additional, Min, Zhuochao, additional, Shi, Yu, additional, Liang, Chengbang, additional, Yu, Rui, additional, Chang, Kexin, additional, Chen, Luyao, additional, Yan, Ke, additional, Wang, Chunxiang, additional, Tan, Yan, additional, Wang, Xu, additional, Chen, JianXin, additional, and Hua, Qian, additional

Published
2023
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183. Pathological diagnostic nomograms for predicting malignant histology and unfavorable pathology in patients with endophytic renal tumor

Author

Deng, Xinxi, Liu, Xiaoqiang, Hu, Bing, Jiang, Ming, Zhu, Ke, Nie, Jianqiang, Liu, Taobin, Chen, Luyao, Deng, Wen, Fu, Bin, and Xiong, Situ

Subjects
Cancer Research, Oncology
Abstract

PurposeTo develop and validate nomograms for pre-treatment prediction of malignant histology (MH) and unfavorable pathology (UP) in patients with endophytic renal tumors (ERTs).MethodsWe retrospectively reviewed the clinical information of 3245 patients with ERTs accepted surgical treatment in our center. Eventually, 333 eligible patients were included and randomly enrolled into training and testing sets in a ratio of 7:3. We performed univariable and multivariable logistic regression analyses to determine the independent risk factors of MH and UP in the training set and developed the pathological diagnostic models of MH and UP. The optimal model was used to construct a nomogram for MH and UP. The area under the receiver operating characteristics (ROC) curves (AUC), calibration curves and decision curve analyses (DCA) were used to evaluate the predictive performance of models.ResultsOverall, 172 patients with MH and 50 patients with UP were enrolled in the training set; and 74 patients with MH and 21 patients with UP were enrolled in the validation set. Sex, neutrophil-to-lymphocyte ratio (NLR), R score, N score and R.E.N.A.L. score were the independent predictors of MH; and BMI, NLR, tumor size and R score were the independent predictors of UP. Single-variable and multiple-variable models were constructed based on these independent predictors. Among these predictive models, the malignant histology-risk nomogram consisted of sex, NLR, R score and N score and the unfavorable pathology-risk nomogram consisted of BMI, NLR and R score performed an optimal predictive performance, which reflected in the highest AUC (0.842 and 0.808, respectively), the favorable calibration curves and the best clinical net benefit. In addition, if demographic characteristics and laboratory tests were excluded from the nomograms, only the components of the R.E.N.A.L. Nephrometry Score system were included to predict MH and UP, the AUC decreased to 0.781 and 0.660, respectively (P=0.001 and 0.013, respectively).ConclusionIn our study, the pathological diagnostic models for predicting malignant and aggressive histological features for patients with ERTs showed outstanding predictive performance and convenience. The use of the models can greatly assist urologists in individualizing the management of their patients.

Published
2022

193. Partial Nephrectomy Versus Radical Nephrectomy for Endophytic Renal Tumors: Comparison of Operative, Functional, and Oncological Outcomes by Propensity Score Matching Analysis

Author

Xiong, Situ, Jiang, Ming, Jiang, Yi, Hu, Bing, Chen, Ru, Yao, Zhijun, Deng, Wen, Wan, Xianwen, Liu, Xiaoqiang, Chen, Luyao, and Fu, Bin

Subjects
Cancer Research, Oncology
Abstract

PurposeThe study aimed to compare operative, functional, and oncological outcomes between partial nephrectomy (PN) and radical nephrectomy (RN) for entophytic renal tumors (ERTs) by propensity score matching (PSM) analysis.MethodsA total of 228 patients with ERTs who underwent PN or RN between August 2014 and December 2021 were assessed. A PSM in a 1:1 ratio was conducted to balance the differences between groups. Perioperative characteristics, renal functional, and oncological outcomes were compared between groups. Univariate and multivariate logistic and Cox proportional hazard regression analyses were used to determine the predictors of functional and survival outcomes.ResultsAfter PSM, 136 cases were matched to the PN group (n = 68) and the RN group (n = 68). Patients who underwent RN had shorter OT, less EBL, and lower high-grade complications (all p p = 0.002), 1-year postoperative 90% eGFR preservation (45.6% vs. 22.1%, p = 0.004), and new-onset CKD Stage ≥III at last follow-up (2.9% vs. 29.4%, p p = 0.005) and long-term renal function decline (OR, 10.242; 95% CI, 2.175–48.240; p = 0.003). Furthermore, PN resulted in a better OS and similar PFS and CSS as compared to RN (p = 0.042, 0.15, and 0.21, respectively). RN (OR, 7.361; 95% CI, 1.143–47.423; p = 0.036) and pT3 stage (OR, 4.241; 95% CI, 1.079–16.664; p = 0.039) were independent predictors of overall mortality.ConclusionAmong patients with ERTs, although the PN group showed a higher incidence of high-grade complications than RN, when technically feasible and with experienced surgeons, PN is recommended for better preservation of renal function, longer OS, and similar oncological outcomes.

Published
2022

194. Accepted manuscript of 'Bridgmanite is nearly dry at the top of the lower mantle' by Liu et al. [Earth Planet. Sci. Lett. 570, 117088, 2021]

Author

Liu, Zhaodong, Fei, Hongzhan, Chen, Luyao, McCammon, Catherine, Wang, Lin, Liu, Ran, Wang, Fei, Liu, Bingbing, and Katsura, Tomoo

Subjects
water solubility, lower mantle, dry, single crystal
Abstract

Accepted manuscript of Liu, Z., Fei, H., Chen, L., McCammon, C., Wang, L., Liu, R., Wang, F., Liu, B., Katsura, T., Bridgmanite is nearly dry at the top of the lower mantle,Earth Planet. Sci. Lett.,570, 117088, 2021. https://doi.org/10.1016/j.epsl.2021.117088 &nbsp

Published
2022
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