1,853 results on '"Chen, Luo"'
Search Results
152. Association of growth differentiation factor-15 level with adverse outcomes in patients with stable coronary artery disease: A meta-analysis
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Li, Tingjian, Chen, Youjin, Ye, Tingting, Zheng, Lin, Chen, Luo, Fan, Yuncao, and Lin, Bin
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- 2022
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153. Time-course transcriptome landscape of achene development in lettuce
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Chen Luo, Shenglin Wang, Kang Ning, Zijing Chen, Jingjing Yang, Yixin Wang, Meixia Qi, and Qian Wang
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Lettuce ,Achene development ,Transcriptome ,Fruit ,Seed ,Transcription factor ,Plant culture ,SB1-1110 - Abstract
Lettuce (Lactuca sativa L.), which belongs to the large Asteraceae (Compositae) family, breeds by sexual reproduction and produces seeds. Actually, lettuce seeds are achenes, which are defined as fruits. However, few studies have described the morphological characteristics of the lettuce achenes, and genes essential for achene development are largely unknown in lettuce. To investigate the gene activity during achene development and determine the possible mechanisms that influence achene development in lettuce, we performed a time-course transcriptome analysis of lettuce achenes. A total of 27,390 expressed genes were detected at the five achene development stages. We investigated the gene expression patterns during achene development and identified the enriched biological processes at the corresponding stages. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses revealed a variety of transcriptomic similarities and differences at different achene development stages. Further, transcription factors and phytohormones were found to play important roles during achene development. Finally, we proposed a working model to illustrate the gene expression modules and possible molecular mechanisms underlying achene development. Our time-course transcriptome data also provide a foundation for future functional studies to reveal the genetic control of achene development in lettuce.
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- 2022
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154. A Clinic-Radiomics Model for Predicting the Incidence of Persistent Organ Failure in Patients with Acute Necrotizing Pancreatitis
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Nan Liu, Yidong Wan, Yifan Tong, Jie He, Shufeng Xu, Xi Hu, Chen Luo, Lei Xu, Feng Guo, Bo Shen, and Hong Yu
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background. Persistent organ failure (POF) is the leading cause of death in patients with acute necrotizing pancreatitis (ANP). Although several risk factors have been identified, there remains a lack of efficient instruments to accurately predict the incidence of POF in ANP. Methods. Retrospectively, the clinical and imaging data of 178 patients with ANP were collected from our database, and the patients were divided into training (n=125) and validation (n=53) cohorts. Through computed tomography image acquisition, the volume of interest segmentation, and feature extraction and selection, a pure radiomics model in terms of POF prediction was established. Then, a clinic-radiomics model integrating the pure radiomics model and clinical risk factors was constructed. Both primary and secondary endpoints were compared between the high- and low-risk groups stratified by the clinic-radiomics model. Results. According to the 547 selected radiomics features, four models were derived from features. A clinic-radiomics model in the training and validation sets showed better predictive performance than pure radiomics and clinical models. The clinic-radiomics model was evaluated by the ratios of intervention and mechanical ventilation, intensive care unit (ICU) stays, and hospital stays. The results showed that the high-risk group had significantly higher intervention rates, ICU stays, and hospital stays than the low-risk group, with the confidence interval of 90% (p
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- 2023
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155. LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway
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Chen Luo, Kang Lin, Cegui Hu, Xiaojian Zhu, Jinfeng Zhu, and Zhengming Zhu
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LINC01094 ,pancreatic cancer ,miR-577 ,LIN28B ,PI3K/AKT pathway ,proliferation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The leading cause of death in pancreatic cancer (PC) patients is the progression of cancer metastasis. Recently, long non-coding RNAs (lncRNAs) have been shown to play an important role in regulating cancer cell proliferation and metastasis; however, its molecular basis in PC remains to be explored. In this study, we observed that LINC01094 was markedly overexpressed in PC tissues and was associated with poor patient prognosis. Downregulation of LINC01094 decreased the proliferation and metastasis of PC cells and inhibited tumorigenesis and metastasis in mouse xenografts. Mechanically, LINC01094 acted as an endogenous miR-577 sponge to increase the expression of its target gene, the RNA-binding protein lin-28 homolog B (LIN28B), by decoying the miR-577, thereby activating the PI3K/AKT pathway. Our findings suggest that LINC01094 plays critical roles in proliferation and metastasis of PC, implying that LINC01094 can be regarded as a new biomarker or therapeutic target for the treatment of PC.
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- 2021
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156. Rapid Contrastive Experimental Study on the Adiabatic Spontaneous Combustion Period of Loose Lignite
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Ziwen Dong, Lifeng Sun, Tinggui Jia, Shengli Guo, Weile Geng, Wenhui Yu, Zikun Pi, Guangli Li, and Chen Luo
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Chemistry ,QD1-999 - Published
- 2021
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157. A novel cement-based auxetic foam composite: Experimental study
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Ge Zhi Fan, Xin Ren, Shi Long Wang, Chen Luo, and Yi Min Xie
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Auxetic ,Cement composite ,Foam material ,Auxetic foam ,Mechanical metamaterial ,Negative Poisson's ratio ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Auxetic foam materials contract (expand) laterally under uniaxial compressive (tensile) load. Due to superior characteristics of auxetic foam, e.g., shear resistance and in-plane indentation resistance, studies of auxetic foam composites have been increasing in recent years. In this paper, a novel cement-based auxetic foam composite is designed, fabricated and experimentally investigated. The influence of foam hole density, mass fraction and age on the flexural and compressive strength of the composite is analyzed. The failure modes and crack development of the specimen are examined. It is found that the flexural and compressive strength of composite are improved at the curing age of 7 and 14 days, and reduced at the curing age of 28 days with the incorporation of auxetic foam. And the flexural compression ratio of the composite is greater than that of matrix material. The integrity of the specimen is preserved during the compression failure process of cement-based auxetic foam composites. It is indicated that the incorporation of auxetic foam improves the toughness and deformation behavior of composites.
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- 2022
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158. Silencing the gustatory receptor BtGR11 affects the sensing of sucrose in the whitefly Bemisia tabaci
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Fengqi Li, Zhongjuan Di, Jiahui Tian, Youssef Dewer, Cheng Qu, Shiyong Yang, and Chen Luo
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RNAi ,phloem-sucking pests ,behavioral regulation ,sugar receptor ,sucrose ,Biotechnology ,TP248.13-248.65 - Abstract
RNA interference (RNAi) is powerful biotechnology for studying the in vivo functions of key genes. Based on this property, RNAi can also be used for pest control as an effective alternative to chemical pesticides. The management of phloem-sucking pests is a tricky issue in current agricultural and forestry pest control. RNAi can silence key chemoreceptor genes of phloem-sucking pests; thereby regulating the behavior of these pests can be manipulated. So, it is considered to be a promising new type of ecological pest management strategy. In this study, we identified a candidate taste receptor gene, BtGR11, that controls the taste sensitivity to sucrose in the whitefly Bemisia tabaci, which is a serious invasive phloem-sucking pest worldwide. Functional analyses using the Xenopus oocyte expression system and the two-electrode voltage-clamp system revealed that the oocytes expressing BtGR11 responded to sucrose. Furthermore, we found that silencing BtGR11 by RNAi inhibited the function of sensing sucrose in the whitefly. This study reports a key chemoreceptor gene that can be used for the understanding of the gustatory sensing mechanisms of whitefly to deterrent.
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- 2022
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159. Systematics of the fleshy-fruited Sonerileae (Melastomataceae)
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Quakenbush, J. Peter, primary, Chen, Luo, additional, Penneys, Darin S., additional, Barkman, Todd J., additional, Liu, Ying, additional, Yakandawala, Deepthi, additional, Libalah, Marie Claire Veranso Epse, additional, and Kadereit, Gudrun, additional
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- 2024
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160. A Time-Identified R-Tree: A Workload-Controllable Dynamic Spatio-Temporal Index Scheme for Streaming Processing
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Peng, Weichen, primary, Chen, Luo, additional, Ouyang, Xue, additional, and Xiong, Wei, additional
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- 2024
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161. An efficient parallel machine learning-based blockchain framework
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Chun-Wei Tsai, Yi-Ping Chen, Tzu-Chieh Tang, and Yu-Chen Luo
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Machine learning ,Blockchain ,Deep learning ,Information technology ,T58.5-58.64 - Abstract
The unlimited possibilities of machine learning have been shown in several successful reports and applications. However, how to make sure that the searched results of a machine learning system are not tampered by anyone and how to prevent the other users in the same network environment from easily getting our private data are two critical research issues when we immerse into powerful machine learning-based systems or applications. This situation is just like other modern information systems that confront security and privacy issues. The development of blockchain provides us an alternative way to address these two issues. That is why some recent studies have attempted to develop machine learning systems with blockchain technologies or to apply machine learning methods to blockchain systems. To show what the combination of blockchain and machine learning is capable of doing, in this paper, we proposed a parallel framework to find out suitable hyperparameters of deep learning in a blockchain environment by using a metaheuristic algorithm. The proposed framework also takes into account the issue of communication cost, by limiting the number of information exchanges between miners and blockchain.
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- 2021
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162. Prosthetic complications of fixed dental prostheses supported by locking-taper implants: a retrospective study with a mean follow-up of 5 years
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Wen mo Gao, Wei Geng, and Chen chen Luo
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Prosthetic complications ,Implant restorations ,Implantology ,Locking-taper implants ,Dentistry ,RK1-715 - Abstract
Abstract Background Restoration with locking-taper implants is a widely used methodology. However, conical connection systems such as locking-taper implant systems have rarely been examined. This study provides a retrospective investigation of locking-taper fixed restorations, mainly focusing on prosthetic complications. Methods Patients undergo treatment with conical connected implants from 2008 to 2010 were examined. Preparation of the implant sites was performed according to the standard procedures for the Bicon system. Bone healing took over 6 months, and the prosthetic procedure was initiated thereafter. Integrated abutment crowns or gold porcelain crowns were used, and the prosthesis type was a single crown or a fixed dental prosthesis. Once the crown was in place, its occlusion was thoroughly checked and adjusted, and then the crown was glazed or finely polished. The Kaplan–Meier method was used to calculate the cumulative complication-free rates for 5 and 10 years. Additionally, a Cox regression model was used to identify the factors that independently influenced the results. Implant survival and marginal bone loss were also investigated. Results A total of 392 patients who underwent 541 implants and 434 locking taper implant-based restorations from 2008 to 2010 were examined. The overall 5-year cumulative complication-free rate was 83.34%. The most common prosthetic complication was veneer chipping, with a frequency of 67.53%. According to the Cox regression model, the complication-free rate of integrated abutment crowns was significantly higher than that of gold porcelain crowns, that of molar regions was significantly higher than that of premolar regions, and that of females was significantly higher than that of males. Only three implant failures happened, and the mean marginal bone loss values at 1- year, 5-years and 10- years were 0.25 mm (95% CI ± 0.12), 0.40 mm (95% CI ± 0.03) and 0.51 mm (95% CI ± 0.05), respectively. Conclusion Veneer chipping was the most common complication with locking-taper implant-supported fixed restorations. The incidence of complications for IACs is significantly higher than that for GPCs. Age, location, and prosthesis type are not determinants of prosthetic complications. Besides, the long-term clinical effect of locking-taper implant can meet the clinical needs. The bone tissue level around the implant can maintain long-term stability.
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- 2021
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163. Identification and tissue distribution of odorant binding protein genes in Harmonia axyridis (Coleoptera: Coccinellidae)
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Cheng QU, Ran WANG, Wu-nan CHE, Feng-qi LI, Hai-peng ZHAO, Yi-yun WEI, Chen LUO, and Ming XUE
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odorant-binding proteins ,Harmonia axyridis ,expression profile ,phylogenetic tree ,Agriculture (General) ,S1-972 - Abstract
The olfactory system of insects is crucial in modulating behaviors such as host seeking, mating, and oviposition. Odorant-binding proteins (OBPs) are involved in semiochemical recognition. OBPs recognize and bind odorants and transport them to odorant receptors located in olfactory neurons. Harmonia axyridis (Coleoptera: Coccinellidae) is a widely used predacious biological control agent for many agricultural and forestry pests. This study identified 19 OBPs in H. axyridis based on the antennal and whole-body transcriptomes of adults and obtained all the full-length open reading frames, including 11 ‘Classic’ OBPs, 7 ‘Minus-C’ OBPs and 1 ‘Plus-C’ OBP. They encoded 125 to 241 amino acid proteins with molecular weights ranging from 13.75 to 27.75 kDa and isoelectric points ranging from 4.15 to 8.80. Phylogenetic analyses were used to study the relationships between H. axyridis OBPs and OBPs from other species of Coleoptera. Quantitative real-time PCR (qPCR) analysis showed that HaxyOBP2, 3, 5, 8, 10, 12, 13, 14, and 15 were highly expressed in antennae of both adult females and males. Moreover, HaxyOBP2, 3, 5, 12, and 15 were more abundantly expressed in antennae than other body parts, while HaxyOBP13 and HaxyOBP14 were expressed predominantly, and at similar levels, in the head and antennae. The other OBP genes were highly expressed in non-olfactory tissues including the thorax, abdomen, legs, and wings. These results provide valuable information for further study of H. axyridis olfaction, which may ultimately enhance its use as a biocontrol agent.
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- 2021
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164. Element-specific contributions to improved magnetic heating of theranostic CoFe2O4 nanoparticles decorated with Pd
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S. Fatemeh Shams, Detlef Schmitz, Alevtina Smekhova, Mohammad Reza Ghazanfari, Margret Giesen, Eugen Weschke, Kai Chen, Chen Luo, Florin Radu, and Carolin Schmitz-Antoniak
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Medicine ,Science - Abstract
Abstract Decoration with Pd clusters increases the magnetic heating ability of cobalt ferrite (CFO) nanoparticles by a factor of two. The origin of this previous finding is unraveled by element-specific X-ray absorption spectroscopy (XAS) and magnetic circular dichroism (XMCD) combined with atomic multiplet simulations and density functional theory (DFT) calculations. While the comparison of XAS spectra with atomic multiplet simulations show that the inversion degree is not affected by Pd decoration and, thus, can be excluded as a reason for the improved heating performance, XMCD reveals two interrelated responsible sources: significantly larger Fe and Co magnetic moments verify an increased total magnetization which enhances the magnetic heating ability. This is accompanied by a remarkable change in the field-dependent magnetization particularly for Co ions which exhibit an increased low-field susceptibility and a reduced spin canting behavior in higher magnetic fields. Using DFT calculations, these findings are explained by reduced superexchange between ions on octahedral lattice sites via oxygen in close vicinity of Pd, which reinforces the dominating antiparallel superexchange interaction between ions on octahedral and tetrahedral lattice sites and thus reduces spin canting. The influence of the delocalized nature of Pd 4d electrons on the neighboring ions is discussed and the conclusions are illustrated with spin density isosurfaces of the involved ions. The presented results pave the way to design nanohybrids with tailored electronic structure and magnetic properties.
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- 2021
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165. Observation of Ten-photon Entanglement Using Thin BiB$_{3}$O$_{6}$ Crystals
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Chen, Luo-Kan, Li, Zheng-Da, Yao, Xing-Can, Huang, Miao, Li, Wei, Lu, He, Yuan, Xiao, Zhang, Yan-Bao, Jiang, Xiao, Peng, Cheng-Zhi, Li, Li, Liu, Nai-Le, Ma, Xiongfeng, Lu, Chao-Yang, Chen, Yu-Ao, and Pan, Jian-Wei
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Quantum Physics - Abstract
We report on the experimental realization of a ten-photon Greenberger-Horne-Zeilinger state using thin BiB$_{3}$O$_{6}$ crystals. The observed fidelity is $0.606\pm0.029$, demonstrating a genuine entanglement with a standard deviation of 3.6 $\sigma$. This result is further verified using $p$-value calculation, obtaining an upper bound of $3.7\times10^{-3}$ under an assumed hypothesis test. Our experiment paves a new way to efficiently engineer BiB$_{3}$O$_{6}$ crystal-based multi-photon entanglement systems, which provides a promising platform for investigating advanced optical quantum information processing tasks such as boson sampling, quantum error correction and quantum-enhanced measurement., Comment: Revised for readability and clarity
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- 2016
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166. Experimental ten-photon entanglement
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Wang, Xi-Lin, Chen, Luo-Kan, Li, Wei, Huang, He-Liang, Liu, Chang, Chen, Chao, Luo, Yi-Han, Su, Zu-En, Wu, Dian, Li, Zheng-Da, Lu, He, Hu, Yi, Jiang, Xiao, Peng, Cheng-Zhi, Li, Li, Liu, Nai-Le, Chen, Yu-Ao, Lu, Chao-Yang, and Pan, Jian-Wei
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Quantum Physics - Abstract
Quantum entanglement among multiple spatially separated particles is of fundamental interest, and can serve as central resources for studies in quantum nonlocality, quantum-to-classical transition, quantum error correction, and quantum simulation. The ability of generating an increasing number of entangled particles is an important benchmark for quantum information processing. The largest entangled states were previously created with fourteen trapped ions, eight photons, and five superconducting qubits. Here, based on spontaneous parametric down-converted two-photon entanglement source with simultaneously a high brightness of ~12 MHz/W, a collection efficiency of ~70% and an indistinguishability of ~91% between independent photons, we demonstrate, for the first time, genuine and distillable entanglement of ten single photons under different pump power. Our work creates a state-of-the-art platform for multi-photon experiments, and provide enabling technologies for challenging optical quantum information tasks such as high-efficiency scattershot boson sampling with many photons., Comment: 65 pages, supplementary information included, with all raw data. to appear in Physical Review Letters
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- 2016
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167. Secret sharing of a quantum state
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Lu, He, Zhang, Zhen, Chen, Luo-Kan, Li, Zheng-Da, Liu, Chang, Li, Li, Liu, Nai-Le, Ma, Xiongfeng, Chen, Yu-Ao, and Pan, Jian-Wei
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Quantum Physics - Abstract
Secret sharing of a quantum state, or quantum secret sharing, in which a dealer wants to share certain amount of quantum information with a few players, has wide applications in quantum information. The critical criterion in a threshold secret sharing scheme is confidentiality, with less than the designated number of players, no information can be recovered. Furthermore, in a quantum scenario, one additional critical criterion exists, the capability of sharing entangled and unknown quantum information. Here by employing a six-photon entangled state, we demonstrate a quantum threshold scheme, where the shared quantum secrecy can be efficiently reconstructed with a state fidelity as high as 93%. By observing that any one or two parties cannot recover the secrecy, we show that our scheme meets the confidentiality criterion. Meanwhile, we also demonstrate that entangled quantum information can be shared and recovered via our setting, which demonstrates that our implemented scheme is fully quantum. Moreover, our experimental setup can be treated as a decoding circuit of the 5-qubit quantum error-correcting code with two erasure errors., Comment: 13 pages, 9 figures
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- 2016
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168. The transcriptional characteristics of NADC34-like PRRSV in porcine alveolar macrophages
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Peixin Wang, Xin Ma, Riteng Zhang, Yongxin Zhao, Ruochen Hu, Chen Luo, Basit Zeshan, Zengqi Yang, Li Qiu, Juan Wang, Haijin Liu, Yefei Zhou, and Xinglong Wang
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PRRSV ,NADC34-like ,comparative transcriptome ,time-course transcriptome ,WGCNA ,Microbiology ,QR1-502 - Abstract
The widespread and endemic circulation of porcine reproductive and respiratory syndrome virus (PRRSV) cause persistent financial losses to the swine industry worldwide. In 2017, NADC34-like PRRSV-2 emerged in northeastern China and spread rapidly. The dynamics analysis of immune perturbations associated with novel PRRSV lineage is still incomplete. This study performed a time-course transcriptome sequencing of NADC34-like PRRSV strain YC-2020-infected porcine alveolar macrophages (PAMs) and compared them with JXA1-infected PAMs. The results illustrated dramatic changes in the host’s differentially expressed genes (DEGs) presented at different timepoints after PRRSV infection, and the expression profile of YC-2020 group is distinct from that of JXA1 group. Functional enrichment analysis showed that the expression of many inflammatory cytokines was up-regulated following YC-2020 infection but at a significantly lower magnitude than JXA1 group, in line with the trends for most interferon-stimulated genes (ISGs) and their regulators. Meanwhile, numerous components of histocompatibility complex (MHC) class II and phagosome presented a stronger transcription suppression after the YC-2020 infection. All results imply that YC-2020 may induce milder inflammatory responses, weaker antiviral processes, and more severe disturbance of antigen processing and presentation compared with HP-PRRSV. Additionally, LAPTM4A, GLMP, and LITAF, which were selected from weighted gene co-expression network analysis (WGCNA), could significantly inhibit PRRSV proliferation. This study provides fundamental data for understanding the biological characteristics of NADC34-like PRRSV and new insights into PRRSV evolution and prevention.
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- 2022
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169. Excavating the social representations and perceived barriers of organ donation in China over the past decade: A hybrid text analysis approach
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Zizhong Zhang, Jing Jin, Chen Luo, and Anfan Chen
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organ donation ,social representation ,China ,semantic network analysis ,conventional content analysis ,cultural factors ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundOrgan donation has been claimed as a prosocial behavior to prolong the recipient's life and deliver great love. However, the supply-demand ratio of organs in China is highly unbalanced. Being entangled with multiple factors derived from individual and supra-individual levels, organ donation in China is important but sensitive. Previous scholars usually depended on obtrusive approaches to explore the facilitators and hindrances of organ donation, which is hard to discover genuine perceptions toward organ donation. Besides, relatively limited scholarly attention has been paid to what hampers organ donation in China.ObjectiveWe intended to excavate the diversified social representations and perceived barriers to organ donation in China over the past decade.MethodTwo kinds of text analysis methods—semantic network analysis and conventional content analysis, were applied to 120,172 posts from ordinary users on the Sina Weibo platform to address the research questions.ResultsRegarding social representations, the “hope, understanding, and acceptance” of organ donation was the most pronounced one (34% of the whole semantic network), followed by “family story” (26%), “the procedure of organ donation in NGOs” (15%), “the practical value of organ donation” (14%), and “organ donation in the medical context” (11%). Regarding perceived barriers, a four-layer framework was constructed, including (1) the individual level, mainly about the fear of death and postmortem autopsy; (2) the familial level, which refers to the opposition from family members; (3) the societal level, which alludes to distrust toward medical institutions and the general society; (4) the cultural level, which covers religious-cultural concerns about fatalism.ConclusionIn concordance with prior works on social representations regarding organ donation, the current study also uncovered the coexistence of antithetical representations about organ donation—the longing for survival and the fear of death. This representation pair serves as the foundation of Chinese people's ambivalence. Besides, family-related narratives were dispersed over various representations, demonstrating the critical position of family support in organ donation. Moreover, the four-layer framework concerning donation barriers affords a reference for future empirical studies. The practical implications of this work are further discussed.
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- 2022
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170. Signature construction and molecular subtype identification based on cuproptosis-related genes to predict the prognosis and immune activity of patients with hepatocellular carcinoma
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Xingyu Peng, Jinfeng Zhu, Sicheng Liu, Chen Luo, Xun Wu, Zitao Liu, Yanzhen Li, and Rongfa Yuan
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cuproptosis ,hepatocellular carcinoma ,immune infiltration ,prognostic signature ,immune microenvironment ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundHepatocellular carcinoma (HCC) is one of the most common malignancies in the world, with high incidence, high malignancy, and low survival rate. Cuproptosis is a novel form of cell death mediated by lipoylated TCA cycle proteins-mediated novel cell death pathway and is highly associated with mitochondrial metabolism. However, the relationship between the expression level of cuproptosis-related genes (CRGs) and the prognosis of HCC is still unclear.MethodsCombining the HCC transcriptomic data from The Cancer Genome Atlas(TCGA) and Gene Expression Omnibus (GEO) databases, we identified the differentially expressed cuproptosis-related genes (DECRGs) and obtained the prognosis-related DECRGs through univariate regression analysis.LASSO and multivariate COX regression analyses of these DECRGs yielded four genes that were used to construct the signature. Next, we use ROC curves to evaluate the performance of signatures. The tumor microenvironment, immune infiltration, tumor mutation load, half-maximum suppression concentration, and immunotherapy effects were also compared between the low-risk and high-risk groups. Finally, we analyzed the expression level, prognosis, and immune infiltration correlation on the four genes that constructed the model.ResultsFour DECRGs s were used to construct the signature. The ROC curves indicated that signature can better assess the prognosis of HCC patients. Patients were grouped according to the signature risk score. Patients in the low-risk group had a significantly longer survival time than those in the high-risk group. Furthermore, the tumor mutation burden (TMB) values were associated with the risk score and the higher-risk group had a higher proportion of TP53 mutations than the low-risk group.ESTIMATE analysis showed significant differences in stromal scores between the two groups.N6-methyladenosine (m6A) and multiple immune checkpoints were expressed at higher levels in the high-risk group. Then, we found that signature score correlated with chemotherapeutic drug sensitivity and immunotherapy efficacy in HCC patients. Finally, we further confirmed that the four DECRGs genes were associated with the prognosis of HCC through external validation.ConclusionsWe studied from the cuproptosis perspective and developed a new prognostic feature to predict the prognosis of HCC patients. This signature with good performance will help physicians to evaluate the overall prognosis of patients and may provide new ideas for clinical decision-making and treatment strategies.
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- 2022
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171. Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
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Yudi Xie, Lei Liu, Jue Wang, Yaqiong Zheng, Chen Luo, Wenxu Ni, Zhihang He, Xin Zhao, Yan Liu, Yingyu He, Shangen Zheng, Ling Li, and Zhong Liu
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SARS-CoV-2 ,convalescent ,vaccine ,neutralization ,delta ,omicron ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundCOVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain.MethodsThe pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group.ResultsIn the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p
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- 2022
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172. Acylsugar protection of Nicotiana benthamiana confers mortality and transgenerational fitness costs in Spodoptera litura
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Ran Wang, Bingli Gao, Qinghe Zhang, Ziyi Zhang, Yunyi Li, Qingyi Yang, Mi Zhang, Wenxiang Li, and Chen Luo
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acylsugar ,Nicotiana benthamiana ,chemical defenses ,Spodoptera litura ,toxicity ,fitness cost ,Plant culture ,SB1-1110 - Abstract
Acylsugars are secondary metabolites that are produced in the trichomes of some solanaceous species and can help control several herbivorous insect pests. Previously, knockout mutations (asat2 mutants) were shown to significantly reduce the acylsugar content of Nicotiana benthamiana, and significantly improve the fitness of six generalist insect herbivores. The current study compared the significant mortality and fitness costs in Spodoptera litura conferred by acylsugar protection of N. benthamiana (wild-type plants) compared to S. litura strains reared in acylsugar-deficient plants with depleted acylsugar biosynthesis. Acylsugar protection prolonged the developmental duration and decreased viability in the larval stages. Further, the fecundity of females and the hatching rate of eggs significantly decreased under acylsugar protection. For F1 offspring, acylsugar protection still exerted significant negative effects on larval survival rate and fecundity per female. The net reproductive rate and relative fitness of the S. litura strain were strongly affected by acylsugar. Altogether, these results indicate that acylsugar could contribute to plant protection due to toxicity to pests, diffused availability, and low environmental persistence. This could represent a complementary and alternative strategy to control populations of insect pests.
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- 2022
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173. Genetic mapping and genome-wide association study identify BhYAB4 as the candidate gene regulating seed shape in wax gourd (Benincasa hispida)
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Chen Luo, Jinqiang Yan, Wenrui Liu, Yuanchao Xu, Piaoyun Sun, Min Wang, Dasen Xie, and Biao Jiang
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wax gourd ,seed shape ,genetic mapping ,genome-wide association study ,YABBY ,BhYAB4 ,Plant culture ,SB1-1110 - Abstract
Wax gourd is an important vegetable crop of the Cucurbitaceae family. According to the shape and structure of the seed coat, the seeds of the wax gourd can be divided into bilateral and unilateral. Bilateral seeds usually germinate quickly and have a high germination rate than unilateral seeds. Thereby, wax gourd varieties with bilateral seeds are more welcomed by seed companies and growers. However, the genetic basis and molecular mechanism regulating seed shape remain unclear in the wax gourd. In this study, the genetic analysis demonstrated that the seed shape of wax gourd was controlled by a single gene, with bilateral dominant to unilateral. Combined with genetic mapping and genome-wide association study, Bhi04G000544 (BhYAB4), encoding a YABBY transcription factor, was identified as the candidate gene for seed shape determination in the wax gourd. A G/A single nucleotide polymorphism variation of BhYAB4 was detected among different germplasm resources, with BhYAB4G specifically enriched in bilateral seeds and BhYAB4A in unilateral seeds. The G to A mutation caused intron retention and premature stop codon of BhYAB4. Expression analysis showed that both BhYAB4G and BhYAB4A were highly expressed in seeds, while the nuclear localization of BhYAB4A protein was disturbed compared with that of BhYAB4G protein. Finally, a derived cleaved amplified polymorphic sequence marker that could efficiently distinguish between bilateral and unilateral seeds was developed, thereby facilitating the molecular marker-assisted breeding of wax gourd cultivars.
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- 2022
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174. Strain tuning of Néel temperature in YCrO3 epitaxial thin films
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Jin Hong Lee, Lourdes Marcano, Raphaël Aeschlimann, Mohamad-Assaad Mawass, Chen Luo, Alexandre Gloter, Julien Varignon, Florin Radu, Sergio Valencia, and Manuel Bibes
- Subjects
Biotechnology ,TP248.13-248.65 ,Physics ,QC1-999 - Abstract
Epitaxial strain is a useful handle to engineer the physical properties of perovskite oxide materials. Here, we apply it to orthorhombic chromites that are a family of antiferromagnets showing fruitful functionalities as well as strong spin–lattice coupling via antisymmetric exchange interaction along Cr–O–Cr bonds. Using pulsed laser deposition, we grow YCrO3 thin films on various substrates imposing strain levels in the range from −1.8% to +0.3%. The films are stoichiometric with a 3+ valence for Cr both within the films and at their surface. They display an antiferromagnetic spin order below their Néel temperature, which we show can be strongly tuned by epitaxial strain with a slope of −8.54 K/%. A dimensionless figure of merit (defined as the slope normalized by the Néel temperature of bulk) is determined to be 6.1, which is larger than that of other perovskites, such as manganites (5.5), ferrites (2.3), or nickelates (4.6). Density functional theory simulations bring insight into the role of Cr–O bond lengths and oxygen octahedral rotations on the observed behavior. Our results shed light on orthorhombic chromites that may offer an energy-efficient piezo-spintronic operation.
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- 2022
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175. A method for sperm activity analysis based on feature point detection network in deep learning
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Zhong Chen, Jinkun Yang, Chen Luo, and Changheng Zhang
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sperm activity analysis ,deep learning ,convolutional neural network ,feature point detection ,tracking ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Sperm motility is an important index to evaluate semen quality. Computer-assisted sperm analysis (CASA) is based on the sperm image, through the image-processing algorithm to detect the position of the sperm target and track tracking, so as to judge the sperm activity. Because of the small and dense sperm targets in sperm images, traditional image-processing algorithms take a long time to detect sperm targets, while target-detection algorithms based on the deep learning have a lot of missed detection problems in the process of sperm target detection. In order to accurately and efficiently analyze sperm activity in the sperm image sequence, this article proposes a sperm activity analysis method based on the deep learning. First, the sperm position is detected through the deep learning feature point detection network based on the improved SuperPoint, then the multi-sperm target tracking is carried out through SORT and the sperm motion trajectory is drawn, and at last the sperm survival is judged through the sperm trajectory to realize the analysis of sperm activity. The experimental results show that this method can effectively analyze the sperm activity in the sperm image sequence. At the same time, the average detection speed of the sperm target detection method in the detection process is 65fps, and the detection accuracy is 92%.
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- 2022
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176. TAGCN: Station-level demand prediction for bike-sharing system via a temporal attention graph convolution network
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Zi, Wenjie, Xiong, Wei, Chen, Hao, and Chen, Luo
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- 2021
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177. Placental chorionic plate-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating macrophage polarization via secreting TSG-6
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Qilin Huang, Xiumei Cheng, Chen Luo, Shuxu Yang, Shuai Li, Bing Wang, Xiaohui Yuan, Yi Yang, Yi Wen, Ruohong Liu, Lijun Tang, and Hongyu Sun
- Subjects
Mesenchymal stem cells ,Placenta ,Severe acute pancreatitis ,Macrophage polarization ,TSG-6 ,Medicine (General) ,R5-920 ,Biochemistry ,QD415-436 - Abstract
Abstract Background Mesenchymal stem cells (MSCs) hold promising potential to treat systemic inflammatory diseases including severe acute pancreatitis (SAP). In our previous study, placental chorionic plate-derived MSCs (CP-MSCs) were found to possess superior immunoregulatory capability. However, the therapeutic efficacy of CP-MSCs on SAP and their underlying mechanism remain unclear. Methods The survival and colonization of exogenous CP-MSCs were observed by bioluminescence imaging and CM-Dil labeling in rodent animal models of SAP. The therapeutic efficacy of CP-MSCs on SAP rats was evaluated by pathology scores, the levels of pancreatitis biomarkers as well as the levels of inflammatory factors in the pancreas and serum. The potential protective mechanism of CP-MSCs in SAP rats was explored by selectively depleting M1 or M2 phenotype macrophages and knocking down the expression of TSG-6. Results Exogenous CP-MSCs could survive and colonize in the injured tissue of SAP such as the lung, pancreas, intestine, and liver. Meanwhile, we found that CP-MSCs alleviated pancreatic injury and systemic inflammation by inducing macrophages to polarize from M1 to M2 in SAP rats. Furthermore, our data suggested that CP-MSCs induced M2 polarization of macrophages by secreting TSG-6, and TSG-6 played a vital role in alleviating pancreatic injury and systemic inflammation in SAP rats. Notably, we found that a high inflammation environment could stimulate CP-MSCs to secrete TSG-6. Conclusion Exogenous CP-MSCs tended to colonize in the injured tissue and reduced pancreatic injury and systemic inflammation in SAP rats through inducing M2 polarization of macrophages by secreting TSG-6. Our study provides a new treatment strategy for SAP and initially explains the potential protective mechanism of CP-MSCs on SAP rats.
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- 2021
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178. Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury
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Pengju Wei, Ke Wang, Chen Luo, Yichen Huang, Dilidaer Misilimu, Huimei Wen, Peng Jin, Chuhua Li, Ye Gong, and Yanqin Gao
- Subjects
White matter injury ,Neutrophil ,Microglia/macrophage ,Blood-brain barrier ,Traumatic brain injury ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background The secondary injury caused by traumatic brain injury (TBI), especially white matter injury (WMI), is highly sensitive to neuroinflammation, which further leads to unfavored long-term outcomes. Although the cross-talk between the three active events, immune cell infiltration, BBB breakdown, and proinflammatory microglial/macrophage polarization, plays a role in the vicious cycle, its mechanisms are not fully understood. It has been reported that cordycepin, an extract from Cordyceps militaris, can inhibit TBI-induced neuroinflammation although the long-term effects of cordycepin remain unknown. Here, we report our investigation of cordycepin’s long-term neuroprotective function and its underlying immunological mechanism. Methods TBI mice model was established with a controlled cortical impact (CCI) method. Cordycepin was intraperitoneally administered twice daily for a week. Neurological outcomes were assessed by behavioral tests, including grid walking test, cylinder test, wire hang test, and rotarod test. Immunofluorescence staining, transmission electron microscopy, and electrophysiology recording were employed to assess histological and functional lesions. Quantitative-PCR and flow cytometry were used to detect neuroinflammation. The tracers of Sulfo-NHS-biotin and Evans blue were assessed for the blood-brain barrier (BBB) leakage. Western blot and gelatin zymography were used to analyze protein activity or expression. Neutrophil depletion in vivo was performed via using Ly6G antibody intraperitoneal injection. Results Cordycepin administration ameliorated long-term neurological deficits and reduced neuronal tissue loss in TBI mice. Meanwhile, the long-term integrity of white matter was also preserved, which was revealed in multiple dimensions, such as morphology, histology, ultrastructure, and electrical conductivity. Cordycepin administration inhibited microglia/macrophage pro-inflammatory polarization and promoted anti-inflammatory polarization after TBI. BBB breach was attenuated by cordycepin administration at 3 days after TBI. Cordycepin suppressed the activities of MMP-2 and MMP-9 and the neutrophil infiltration at 3 days after TBI. Moreover, neutrophil depletion provided a cordycepin-like effect, and cordycepin administration united with neutrophil depletion did not show a benefit of superposition. Conclusions The long-term neuroprotective function of cordycepin via suppressing neutrophil infiltration after TBI, thereby preserving BBB integrity and changing microglia/macrophage polarization. These findings provide significant clinical potentials to improve the quality of life for TBI patients.
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- 2021
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179. A nomogram for individualized prediction of overall survival in patients with newly diagnosed glioblastoma: a real-world retrospective cohort study
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Nijiati Kudulaiti, Zhirui Zhou, Chen Luo, Jie Zhang, Fengping Zhu, and Jinsong Wu
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Glioblastoma ,Nomogram ,Lasso-Cox regression ,Prognosis ,Surgery ,RD1-811 - Abstract
Abstract Background This study aimed to identify the most valuable predictors of prognosis in glioblastoma (GBM) patients and develop and validate a nomogram to estimate individualized survival probability. Methods We conducted a real-world retrospective cohort study of 987 GBM patients diagnosed between September 2010 and December 2018. Computer generated random numbers were used to assign patients into a training cohort (694 patients) and internal validation cohort (293 patients). A least absolute shrinkage and selection operator (LASSO)-Cox model was used to select candidate variables for the prediction model. Cox proportional hazards regression was used to estimate overall survival. Models were internally validated using the bootstrap method and generated individualized predicted survival probabilities at 6, 12, and 24 months, which were compared with actual survival. Results The final nomogram was developed using the Cox proportional hazards model, which was the model with best fit and calibration. Gender, age at surgery, extent of tumor resection, radiotherapy, chemotherapy, and IDH1 mutation status were used as variables. The concordance indices for 6-, 12-, 18-, and 24-month survival probabilities were 0.776, 0.677, 0.643, and 0.629 in the training set, and 0.725, 0.695, 0.652, and 0.634 in the validation set, respectively. Conclusions Our nomogram that assesses individualized survival probabilities (6-, 12-, and 24-month) in newly diagnosed GBM patients can assist healthcare providers in optimizing treatment and counseling patients. Trial registration: retrospectively registered.
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- 2021
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180. HiVision: Rapid visualization of large-scale spatial vector data
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Ma, Mengyu, Wu, Ye, Ouyang, Xue, Chen, Luo, Li, Jun, and Jing, Ning
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- 2021
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181. The Functionalized N-Rich Covalent Organic Framework for Palladium Removal from Nuclear Wastewater
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Junli, Wang, chen, Luo, Wentao, Wang, Hui, Wang, Jiaxuan, Shi, Taihong, Yan, and Jianwei, Li
- Abstract
Efficiently adsorbing Pd(II) from acidic radioactive waste liquid is crucial for ensuring the safety of the radioactive waste vitrification process and significantly alleviating the scarcity of precious metals. However, the stability and selectivity of most current adsorbents are limited, hindering their practical application under acidic conditions. To address these limitations, a covalent organic framework (DHTP-TPB COF) was prepared with a high nitrogen content, leveraging the high affinity of its soft ligand Nwith palladium to achieve high selectivity. This work demonstrated that DHTP-TPB COF exhibits rapid adsorption kinetics, with equilibrium achieved within 10 min. The framework also boasts a high adsorption capacity of 142.8 mg/g and impressive reusability in 1.0 M nitric acid. Moreover, the DHTP-TPB COF displays excellent selectivity for Pd(II), even in the presence of 13 interfering ions. By combining FT-IR, XPS spectroscopy, and DFT theoretical calculations, the dense Nsites in the framework have a strong affinity for Pd(II), resulting in exceptional adsorption performance that was confirmed. The findings of this study highlight the potential of COFs with robust linkers and customized functional groups to effectively and selectively capture Pd(II) under harsh environmental conditions of high-level liquid waste.
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- 2024
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182. Joint Client Selection and Model Compression for Efficient FL in UAV-Assisted Wireless Networks
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Chen, Luo, Wang, Ruyan, Cui, Yaping, He, Peng, and Duan, Ang
- Abstract
Deploying federated learning (FL) applications in unmanned aerial vehicle (UAV)-assisted wireless networks can enable ground terminals (GTs) to perform complex machine learning tasks with their own data. However, the FL is inefficient in practice due to the massive model parameters and device heterogeneity. In this paper, we propose a joint client selection and model compression scheme for FL (csmcFL) to improve training efficiency. Specifically, the average throughput of users is first improved by optimizing the UAV deployment location based on user communication fairness. Then, a low-rank decomposition of the fully connected layer in the CNN is performed to compress the model parameters, and partial devices are screened to implement model compression through the client selection strategy to alleviate the excessive aggregation time due to device heterogeneity. We perform extensive simulation experiments in different data distribution scenarios, and the experimental results show that the proposed scheme significantly reduces the data volume of the transmitted model while achieving higher model accuracy compared to the baseline scheme.
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- 2024
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183. A spatiotemporal hierarchical attention mechanism-based model for multi-step station-level crowd flow prediction
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Zhou, Yirong, Li, Jun, Chen, Hao, Wu, Ye, Wu, Jiangjiang, and Chen, Luo
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- 2021
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184. Consciousness can overflow report: Novel evidence from attribute amnesia of a single stimulus
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Wang, Rui, Fu, Yingtao, Chen, Luo, Chen, Yutong, Zhou, Jifan, and Chen, Hui
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- 2021
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185. Information Entropy Based on Propagation Feature of Node for Identifying the Influential Nodes.
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Linfeng Zhong, Yu Bai, Yan Tian, Chen Luo, Jin Huang, and Weijun Pan
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- 2021
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186. PSpec-SQL: Enabling Fine-Grained Control for Distributed Data Analytics.
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Chen Luo 0002, Fei He 0001, Fei Peng, Dong Yan, Dan Zhang, and Xin Zhou
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- 2021
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187. Multi-Material Decomposition for Single Energy CT Using Material Sparsity Constraint.
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Yi Xue, Wenjian Qin, Chen Luo, Pengfei Yang, Yangkang Jiang, Tiffany Tsui, Hongjian He, Li Wang 0033, Jiale Qin, Yaoqin Xie, and Tianye Niu
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- 2021
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188. A Fast Bi-Directional A* Algorithm Based on Quad-Tree Decomposition and Hierarchical Map.
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Yijun Zhou, Jiadong Xi, and Chen Luo
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- 2021
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189. Early Stage Variation Simulation and Visualization of Compliant Part Based on Parametric Space Envelope.
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Chen Luo, Pasquale Franciosa, Darek Ceglarek, Zhonghua Ni, and Zhijie Mo
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- 2021
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190. A novel method for reconstructing general 3D curves from stereo images.
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Yijun Zhou, Jianan Zhao 0008, and Chen Luo
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- 2021
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191. Role of CNSs Conserved Distal Cis-Regulatory Elements in CD4 + T Cell Development and Differentiation
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Xunyi Long, Chen Luo, and Zhengming Zhu
- Subjects
human ,CNSs ,T-cells ,gene regulation ,cell differentiation ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Naïve CD4+ T cells differentiate into diverse subsets of effector cells and perform various homeostatic and immune functions. The differentiation and maintenance of these different subsets are controlled through the upregulation and silencing of master genes. Mechanistic studies of the regulation of these master genes identified conserved and distal intronic regulatory elements, which are accessible subsets of conserved non-coding sequences (CNSs), acting as cis-regulatory elements in a lineage-specific manner that controls the function of CD4+ T cells. Abnormal CNS activity is associated with incorrect expression of master genes and development of autoimmune diseases or immune suppression. Here, we describe the function of several conserved, distal cis-regulatory elements at the Foxp3, Rorc, Il-4, Il-10 and Il-17 gene locus were shown to play important roles in CD4+ T cells differentiation. Together, this review briefly outlines currently known CNSs, with a focus on their regulations and functions in complexes modulating the differentiation and maintenance of various CD4+ T cells subsets, in health and disease contexts, as well as during the conversion of T regulatory cells to T helper 17 cells. This article will provide a comprehensive view of CNSs conserved distal cis-regulatory elements at a few loci that control aspects of CD4+ T cells function.
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- 2022
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192. Identification and Detection of CYP4G68 Overexpression Associated With Cyantraniliprole Resistance in Bemisia tabaci From China
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Ran Wang, Wunan Che, Cheng Qu, Jinda Wang, and Chen Luo
- Subjects
Bemisia tabaci ,cyantraniliprole ,resistance management ,field-evolved resistance ,P450s ,overexpression ,Environmental sciences ,GE1-350 - Abstract
Bemisiatabaci, the tobacco whitefly, is one of the most notorious agricultural sucking insect pests that severely damage a series of crops worldwide. Throughout China, B. tabaci threatens agricultural production with increasing cases of resistance to commonly used insecticides, prompting the widespread use of cyantraniliprole as an alternative to control hemipteran pests. Here, we found overexpression of the CYP4G68 gene conferring cyantraniliprole resistance using quantitative real-time PCR (qPCR) and RNA interference (RNAi) in one lab-selected resistant strain CYAN-R (to about 80-fold higher than control). Furthermore, we measured levels of resistance to cyantraniliprole in whiteflies with 18 field-sampled populations across China and then confirmed that, among them, 14 field-sampled populations showed low-to-high resistance to cyantraniliprole compared with the susceptible strain. We measured CYP4G68 expression in the 14 field populations, and the results of qPCR and RNAi indicated that in two of these populations, Haikou and Wuhan, significant overexpression of CYP4G68 contributed to the development of field-evolved resistance to cyantraniliprole. These results indicate the need to facilitate strategies of management to delay the evolution of resistance to cyantraniliprole and control of whiteflies more sustainably, and to prevent overuse of insecticides in the environment through rational application practices.
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- 2022
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193. Selection and Evaluation of Reference Genes for miRNA Expression Analysis in Bemisia tabaci Under Insecticide Tolerance
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Qinghe Zhang, Bingli Gao, Cheng Qu, Chen Luo, Jinda Wang, and Ran Wang
- Subjects
Bemisia tabaci ,miRNA ,reference gene ,normalization ,expression profiles ,insecticide tolerance ,Genetics ,QH426-470 - Abstract
A growing number of studies have focused on the microRNA (miRNA) expression in Bemisia tabaci, one devastating agricultural insect pest of the tropical and subtropical areas for which the primary means of control are insecticides. In studying the genetic underpinnings of insecticide resistance, the choice of stable reference genes for normalizing data plays a key role to acquire unbiased expression profile results from quantitative real-time PCR (qPCR) analysis. Expression profiles of 11 selected reference genes were determined systematically in B. tabaci exposure to 11 insecticides. Furthermore, we assessed the stability of all the selected candidates in relation to other variables including sex, tissue type, and developmental stage. Candidate reference gene validation was conducted by analyzing the let-7-5p expression under various experimental treatments. Five programs BestKeeper, NormFinder, geNorm, △Ct, and RefFinder were applied to verify the accuracy of the selected candidates. Our results displayed that the best choices of the selected candidates for pymetrozine, sulfoxaflor, flonicamid, cyantraniliprole, afidopyropen, and deltamethrin treatment were miR-1-3p and miR-100-5p, U6 and miR-100-5p were best for chlorpyrifos and imidacloprid treatments, and U6 and miR-1-3p were best for flupyradifurone and β-cypermethrin treatments. The reference genes miR-624, miR-252, and miR-275 worked best in adult tissues, miR-100-5p and miR-1-3p worked best in either sex, and miR-624 and miR-11 were best to use across developmental stages. Not even one reference gene was found to be suitable for all experimental conditions. Our results contributed to the growing body of the literature on qPCR reference gene selection under various experimental conditions and facilitate further investigation on gene expression changes in B. tabaci, resulting from pesticide exposure.
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- 2022
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194. Experimental quantum channel simulation
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Lu, He, Liu, Chang, Wang, Dong-Sheng, Chen, Luo-Kan, Li, Zheng-Da, Yao, Xing-Can, Li, Li, Liu, Nai-Le, Peng, Cheng-Zhi, Sanders, Barry C., Chen, Yu-Ao, and Pan, Jian-Wei
- Subjects
Quantum Physics - Abstract
Quantum simulation is of great importance in quantum information science. Here, we report an experimental quantum channel simulator imbued with an algorithm for imitating the behavior of a general class of quantum systems. The reported quantum channel simulator consists of four single-qubit gates and one controlled-NOT gate. All types of quantum channels can be decomposed by the algorithm and implemented on this device. We deploy our system to simulate various quantum channels, such as quantum-noise channels and weak quantum measurement. Our results advance experimental quantum channel simulation, which is integral to the goal of quantum information processing., Comment: This version is very closed to the published version
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- 2015
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195. Arsenic in the Pearl River Delta and its related waterbody, South China: occurrence and sources, a review
- Author
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Chen Luo, Joyanto Routh, Dinggui Luo, Lezhang Wei, and Yu Liu
- Subjects
Arsenic sources ,Geogenic ,Anthropogenic ,Water ,Soil ,Rice ,Science ,Geology ,QE1-996.5 - Abstract
Abstract The Pearl River Delta (PRD) is a densely populated special economic zone in South China where rapid development since the late 1990s coincided with an increase of many environmental problems in recent years. One of these concerns is the high concentration of arsenic (As; up to 300 μg/L in groundwater) that has been documented in the PRD. Likewise, in surface water and soils, As levels are comparatively higher than in other places in China. Arsenic is discharged from various geogenic sources and anthropogenic activities along the river courses before it drains into the Pearl River Estuary. In general, relatively low As concentrations in the river are due to the limited input from weathering of parent rocks. In contrast, where mining is an important industry, As levels in the surroundings are higher, exceeding the national and international standards for drinking water and soil. The presence of sulfide ores and mining operations, such as extraction of heavy metals and disposal of mine tailings, are most likely responsible for the sharp increase of As above background levels in several tributaries draining into the Pearl River. Besides, in the middle and lower reaches of the tributaries, other anthropogenic sources, e.g., industrial effluents and domestic sewage discharge play an important role in increasing As levels. Finally, rice cultivated in the contaminated areas accumulates As and poses a health risk to the local people in the watershed.
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- 2021
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196. Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer
- Author
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Kang Lin, Xiaojian Zhu, Chen Luo, Fanqin Bu, Jinfeng Zhu, and Zhengming Zhu
- Subjects
bioinformatics analysis ,biomarkers ,CEP55 ,colorectal cancer ,p53/p21 axis ,prognosis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Introduction Colorectal cancer (CRC) is a common tumor with high morbidity and mortality. Current specific diagnosis regarding CRC remains complicated and costly, and specific diagnostic biomarkers are lacking. Methods To find potential diagnostic and prognostic biomarkers for CRC, we screened and analyzed many CRC sequencing data by The Cancer Genome Atlas Program and Gene Expression Omnibus, and validated that CEP55 may be a potential diagnostic biomarker for CRC by molecular cytological experiments and immunohistochemistry, among others. Results We found that CEP55 is upregulated in CRC tissues and tumor cells and can promote CRC proliferation and metastasis by activating the p53/p21 axis and that CEP55 mutations in tumor patients result in worse overall survival and disease‐free survival time. Besides, we also found that genes, such as CDK1, CCNB1, NEK2, KIF14, CDCA5, and RFC3 were upregulated in tumors, and their mutations would affect the prognosis of CRC patients, but these results await for more experimental evidence. Conclusion Our study validates CEP55 as a potential diagnostic and prognostic biomarker for CRC, and we also provide multiple genes and potential molecular mechanisms that may serve as diagnostic and prognostic markers for CRC.
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- 2021
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197. Effect of adenosine monophosphate‐activated protein kinase–p53–Krüppel‐like factor 2a pathway in hyperglycemia‐induced cardiac remodeling in adult zebrafish
- Author
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Qiuyun Wang, Chen Luo, Guoping Lu, and Zhenyue Chen
- Subjects
Adenosine monophosphate‐activated protein kinases ,Diabetic cardiomyopathies ,Zebrafish ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Aims/Introduction Diabetic cardiomyopathy is a type of myocardial disease. It causes left ventricular hypertrophy, followed by diastolic and systolic dysfunction, eventually leading to congestive heart failure. However, the underlying mechanism still requires further elucidation. Materials and Methods A high‐glucose zebrafish model was constructed by administering streptozocin intraperitoneally to enhance the development of cardiomyopathy and then treated with adenosine monophosphate‐activated protein kinase (AMPK) activator. Cardiac structure and function, and protein and gene expression were then analyzed. Cardiomyocytes (CMs) culture in vitro using lentivirus were used for detection of AMPK, p53 and Krüppel‐like factor 2a (klf2a) gene expression. Results In the hyperglycemia group, electrocardiogram findings showed arrhythmia, echocardiography results showed heart enlargement and dysfunction, and many differences, such as increased apoptosis and myocardial fiber loss, were observed. The phospho‐AMPK and klf2a expression were downregulated, and p53 expression was upregulated. Activation of phospho‐AMPK reduced p53 and increased klf2a expression, alleviated apoptosis in CMs and improved cardiac function in the hyperglycemic zebrafish. In vitro knockdown system of AMPK, p53 and klf2a using lentivirus illustrated an increased p53 expression and decreased klf2a expression in CMs by inhibiting AMPK. Repression of p53 and upregulation of klf2a expression were observed, but no changes in the expression of AMPK and its phosphorylated type. Conclusions In the model of streptozocin‐induced hyperglycemia zebrafish, the reduction of phosphorylated AMPK increased p53, which led to KLF2a decrease to facilitate apoptosis of CMs, inducing the cardiac remodeling and cardiac dysfunction. These results can be reversed by AMPK activator, which means the AMPK–p53–klf2a pathway might be a potential target for diabetic cardiomyopathy intervention.
- Published
- 2021
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198. Facile fabrication of paper-based flexible thermoelectric generator
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Zuoyuan Dong, Hua Liu, Xin Yang, Jichen Fan, Hengchang Bi, Chaolun Wang, Yonghua Zhang, Chen Luo, Xinqian Chen, and Xing Wu
- Subjects
Electronics ,TK7800-8360 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract Paper, as a foldable, pollution-free, and low-cost material, has become a suitable support substrate for producing flexible thermoelectric (TE) generators to realize waste heat recycling and the application of human-powered electronic devices. We propose a facile fabrication method to modify cellulose paper with inorganic TE powders via vacuum filtration, making a modified paper that possesses good thermoelectric properties. By connecting the modified paper to copper foils, flexible paper-based TE generators (PTGs) are fabricated. The obtained PTG with three units of P–N modules can generate an output voltage of ∼41.2 mV at a temperature difference of 50 K. Based on this modified paper, a thermal sensor that responds to heat sources, such as fingers, is proposed with a rapid response time of 0.25 s. This work offers a promising strategy for the simple fabrication of PTGs, paving the way for achieving the commercial application of self-powered wearable electronics.
- Published
- 2021
- Full Text
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199. Insecticide Resistance and Its Management in Two Invasive Cryptic Species of Bemisia tabaci in China
- Author
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Qian Wang, Chen Luo, and Ran Wang
- Subjects
Bemisia tabaci ,invasive whiteflies ,insecticide resistance ,pest control ,resistance management ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The sweet potato whitefly Bemisia tabaci is a major agricultural pest with a wide host range throughout the world. The species designation for B. tabaci includes numerous distinct cryptic species or biotypes. Two invasive B. tabaci biotypes, MEAM1 (B) and MED (Q), were found in China at the end of the 20th century and at the beginning of the 21st century. MEAM1 (B) and MED (Q) show higher pesticide resistance levels than native strains, and the levels of resistance vary with changes in insecticide selection pressure. Recent studies have revealed metabolic resistance mechanisms and target site mutations in invasive B. tabaci strains that render them resistant to a range of insecticides and have uncovered the frequency of these resistance-related mutations in B. tabaci populations in China. Novel pest control agents, such as RNA-based pesticides and nano-pesticides, have achieved effective control effects in the laboratory and are expected to be applied for field control of B. tabaci in the future. In this review, we discuss the mechanisms of resistance developed by these invasive B. tabaci populations since their invasion into China. We also provide suggestions for ecologically sound and efficient B. tabaci control.
- Published
- 2023
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200. Baseline Susceptibility, Cross-Resistance, and Sublethal Effects of Broflanilide, a Novel Meta-Diamide Pesticide, in Spodoptera litura
- Author
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Yunyi Li, Cheng Qu, Qinghe Zhang, Liping Zhang, Chen Luo, and Ran Wang
- Subjects
Spodoptera litura ,insecticide sensitivity ,field-evolved resistance ,cross-resistance ,sublethal effects ,detoxifying enzymes ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Spodoptera litura is a damaging and notorious insect pest of agricultural crops that has developed resistance to various insecticides. Broflanilide is a novel pesticide with a unique mode of action that displays high efficiency against lepidopterous larvae. We here determined the baseline susceptibility of a laboratory strain of S. litura to broflanilide and 10 other popular insecticides. Furthermore, we measured susceptibility and cross-resistance using three common insecticides in 11 field-collected S. litura populations. Broflanilide caused the highest toxicity among all tested insecticides, with the laboratory strain and all field-collected populations showing high susceptibility. Moreover, no cross-resistance was detected between broflanilide and the other tested insecticides. We subsequently evaluated the sublethal effects of broflanilide and found that treatment with the 25% lethal concentration (LC25) prolonged the development duration in the larvae, reduced the pupation rate and pupae weight, and decreased egg hatchability. Finally, the activities of three detoxifying enzymes were measured in S. litura after treatment with the LC25 dose. The results suggested that enhanced cytochrome P450 monooxygenase (P450) activity could be involved in broflanilide detoxification. Overall, these findings demonstrate the strong toxicity and significant sublethal effects of broflanilide in S. litura and suggest that increased P450 activity may be associated with broflanilide detoxification.
- Published
- 2023
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