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1,219 results on '"Chen, Hung-Chun"'

159. A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis

Author

Wu, Ping-Hsun, Yi-Ting, Lin, Wu, Pei-Yu, Huang, Jiun-Chi, Chen, Szu-Chia, Chang, Jer-Ming, Chen, Hung-Chun, Wu, Ping-Hsun, Yi-Ting, Lin, Wu, Pei-Yu, Huang, Jiun-Chi, Chen, Szu-Chia, Chang, Jer-Ming, and Chen, Hung-Chun

Abstract

Patients with end-stage renal disease (ESRD) have an increased risk of both impaired cognitive function and peripheral artery disease (PAD) than the general population. The association between PAD and dementia is recognized, but there are limited studies in patients with ESRD. The aim of this study was to evaluate the relationship between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) and cognitive impairment in patients receiving hemodialysis (HD). We enrolled 136 prevalent HD patients (mean age 59.3 +/- 10.5 years, 55.9% male). Cognitive performance was measured using the Montreal Cognitive Assessment (MoCA) and Cognitive Abilities Screening Instrument (CASI) by trained psychiatrists. Associations between the cognitive function and ABI and baPWV were assessed using multiple linear regression analysis. Compared with HD patients with ABI >= 0.9, patients with ABI<0.9 had lower MoCA score (p=0.027) and lower CASI score but did not achieve significant level (p=0.056). In the multivariate stepwise linear regression analysis, ABI (per 0.1) was independently positively associated with the MoCA score (beta coefficient=0.62, p=0.011) and the CASI score (beta coefficient=1.43, p=0.026). There is a negative association between baPWV (per 100cm/s) and CASI (beta coefficient=-0.70, p=0.009). In conclusion, a low ABI or high baPWV was associated with a lower cognitive function in HD patients.

Published
2019
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172. Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients

Author

Huang, Jiun-Chi, primary, Su, Ho-Ming, additional, Wu, Pei-Yu, additional, Lee, Jia-Jung, additional, Lee, Wen-Hsien, additional, Chen, Szu-Chia, additional, Chiu, Yi-Wen, additional, Hsu, Ya-Ling, additional, Chang, Jer-Ming, additional, and Chen, Hung-Chun, additional

Published
2019
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174. Effects of Sustained‐Release Beraprost in Patients With Primary Glomerular Disease or Nephrosclerosis: CASSIOPEIR Study Results

Author

Nakamoto, Hidetomo, primary, Yu, Xue‐Qing, additional, Kim, Suhnggwon, additional, Origasa, Hideki, additional, Zheng, Hongguang, additional, Chen, Jianghua, additional, Joo, Kwon Wook, additional, Sritippayawan, Suchai, additional, Chen, Qinkai, additional, Chen, Hung‐Chun, additional, Tsubakihara, Yoshiharu, additional, Tamai, Hirofumi, additional, Song, Sang Heon, additional, Vaithilingam, Indralingam, additional, Lee, Kang Wook, additional, Shu, Kuo‐Hsiung, additional, Hok‐King Lo, Stanley, additional, Isono, Masanao, additional, Kurumatani, Hajimu, additional, Okada, Kiyonobu, additional, Kanoh, Hiroyuki, additional, Kiriyama, Takashi, additional, Yamada, Shunsuke, additional, and Fujita, Toshiro, additional

Published
2019
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175. Urinary Melamine Levels and Progression of CKD

Author

Tsai, Yi-Chun, primary, Wu, Chia-Fang, additional, Liu, Chia-Chu, additional, Hsieh, Tusty-Jiuan, additional, Lin, Yu-Ting, additional, Chiu, Yi-Wen, additional, Hwang, Shang-Jyn, additional, Chen, Hung-Chun, additional, and Wu, Ming-Tsang, additional

Published
2019
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179. Risk factors for thyroid surgery-related unilateral vocal fold paralysis.

Author

Chen, Hung‐Chun, Pei, Yu‐Cheng, Fang, Tuan‐Jen, Chen, Hung-Chun, Pei, Yu-Cheng, and Fang, Tuan-Jen

Abstract

Objectives/hypothesis: We aimed to identify the risk factors for iatrogenic unilateral vocal fold paralysis (UVFP) caused by thyroid surgery, to allow the identification of patients requiring nerve-protection procedures and monitoring technologies.Study Design: Retrospective case study in a medical center.Methods: Patients who underwent thyroid surgery from April 2011 to February 2016 and who were diagnosed with UVFP by laryngoscopy and laryngeal electromyography were included. Patient demographics, types of surgery, and characteristics of the thyroid lesions were analyzed.Results: Sixty (2.1%) of 2,815 patients who received thyroid surgery developed UVFP. The risk of UVFP was higher in patients over 60 years old (odds ratio, 1.89; 95% confidence interval, 1.01-3.26; P = .01). Involvement of the external branch of superior laryngeal nerve (EBSLN) occurred in 19 (31.7%) of the 60 UVFP patients, and was more likely to occurr in patients with diabetes mellitus (odds ratio, 14.19; 95% confidence interval, 3.80-52.94; P < .001). The incidence of UVFP and involvement of the EBSLN differed among surgery types, and was the highest among patients undergoing total thyroidectomy with neck dissection (TTND) (10/158, 6.3% and 5/158, 3.2%, respectively).Conclusions: The risk of thyroid surgery-related UVFP is higher in older patients. EBSLN involvement is more likely in patients with diabetes mellitus. TTND is associated with higher risks of UVFP and EBSLN injury than other types of surgery, implying the need of intraoperative nerve monitoring in these high-risk characteristics.Level Of Evidence: 4 Laryngoscope, 129:275-283, 2019. [ABSTRACT FROM AUTHOR]

Published
2019
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185. Abatacept in B7-1–Positive Proteinuric Kidney Disease

Author

Yu, Chih-Chuan, Fornoni, Alessia, Weins, Astrid, Hakroush, Samy, Maiguel, Dony, Sageshima, Junichiro, Chen, Linda, Ciancio, Gaetano, Faridi, Mohd Hafeez, Behr, Daniel, Campbell, Kirk N, Chang, Jer-Ming, Chen, Hung-Chun, Oh, Jun, Faul, Christian, Arnaout, M Amin, Fiorina, Paolo, Gupta, Vineet, Greka, Anna, Burke, George W, and Mundel, Peter

Subjects
musculoskeletal diseases, Adult, Male, medicine.medical_specialty, Immunoconjugates, Kidney Disease, Adolescent, Renal and urogenital, Urology, urologic and male genital diseases, Medical and Health Sciences, Article, Focal Segmental, Abatacept, Young Adult, Glomerulosclerosis, Rare Diseases, General & Internal Medicine, medicine, Humans, Child, urogenital system, Glomerulosclerosis, Focal Segmental, Podocytes, business.industry, General Medicine, medicine.disease, female genital diseases and pregnancy complications, Proteinuria, B7-1 Antigen, Female, business, Biomarkers, medicine.drug, Kidney disease
Abstract

Abatacept (cytotoxic T-lymphocyte–associated antigen 4–immunoglobulin fusion protein [CTLA-4–Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who had focal segmental glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and one with primary FSGS) and proteinuria with B7-1 immunostaining of podocytes in kidney-biopsy specimens. Abatacept induced partial or complete remissions of proteinuria in these patients, suggesting that B7-1 may be a useful biomarker for the treatment of some glomerulopathies. Our data indicate that abatacept may stabilize β1-integrin activation in podocytes and reduce proteinuria in patients with B7-1–positive glomerular disease.

Published
2014
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189. Effects of Sustained‐Release Beraprost in Patients With Primary Glomerular Disease or Nephrosclerosis: CASSIOPEIR Study Results.

Author

Nakamoto, Hidetomo, Yu, Xue‐Qing, Kim, Suhnggwon, Origasa, Hideki, Zheng, Hongguang, Chen, Jianghua, Joo, Kwon Wook, Sritippayawan, Suchai, Chen, Qinkai, Chen, Hung‐Chun, Tsubakihara, Yoshiharu, Tamai, Hirofumi, Song, Sang Heon, Vaithilingam, Indralingam, Lee, Kang Wook, Shu, Kuo‐Hsiung, Hok‐King Lo, Stanley, Isono, Masanao, Kurumatani, Hajimu, and Okada, Kiyonobu

Subjects
DRUG side effects, CHRONIC kidney failure, CONTROLLED release preparations, KIDNEY glomerulus diseases, CHRONICALLY ill, ADVERSE health care events
Abstract

TRK‐100STP, a sustained‐release preparation of the orally active prostacyclin analogue beraprost sodium, targets renal hypoxia. This study aimed to show the superiority of TRK‐100STP over placebos in patients with chronic kidney disease (with either primary glomerular disease or nephrosclerosis) to determine the recommended dose. CASSIOPEIR (Chronic Renal Failure Asian Study with Oral PGI2 Derivative for Evaluating Improvement of Renal Function) was a randomized, double‐blind, placebo‐controlled study conducted at 160 sites in seven Asia‐Pacific countries and regions. Eligible patients (n = 892) were randomized to TRK‐100STP 120, 240 μg, or placebo for a treatment period of up to 4 years. The primary efficacy endpoint was time to first occurrence of a renal composite: doubling of serum creatinine or occurrence of end‐stage renal disease. No significant differences were observed in composite endpoints between TRK‐100STP and placebo (P = 0.5674). Hazard ratios (95% CI) in the TRK‐100STP 120 and 240 μg vs. placebo groups were 0.98 (0.78, 1.22) and 0.91 (0.72, 1.14), respectively. The overall incidence of adverse events and adverse drug reactions was comparable between treatment arms. [ABSTRACT FROM AUTHOR]

Published
2020
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199. Independent Association of Overhydration with All-Cause and Cardiovascular Mortality Adjusted for Global Left Ventricular Longitudinal Systolic Strain and E/E’ Ratio in Maintenance Hemodialysis Patients

Author

Huang, Jiun-Chi, primary, Tsai, Yi-Chun, additional, Wu, Pei-Yu, additional, Lee, Jia-Jung, additional, Chen, Szu-Chia, additional, Chiu, Yi-Wen, additional, Hsu, Ya-Ling, additional, Chang, Jer-Ming, additional, and Chen, Hung-Chun, additional

Published
2018
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