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2,464 results on '"Chen, H-C"'

152. Proteome analysis of Sinorhizobium meliloti .

Author

Djordjevic, M. A., primary, Natera, S. H., additional, Chen, H. C., additional, Weiller, G., additional, Menzel, C., additional, Noorden, G. van, additional, Weinman, J., additional, Taylor, S., additional, Guo, K., additional, and Rolfe, B. G., additional

Published
2002
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161. Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

Author

Lucic, B. (Bojana), Chen, H.-C. (Heng-Chang), Kuzman, M. (Maja), Zorita, E. (Eduard), Wegner, J. (Julia), Minneker, V. (Vera), Wang, W. (Wei), Fronza, R. (Raffaele), Laufs, S. (Stefanie), Schmidt, M. (Manfred), Stadhouders, R. (Ralph), Roukos, V. (Vassilis), Vlahovicek, K. (Kristian), Filion, G.J. (Guillaume J.), Lusic, M. (Marina), Lucic, B. (Bojana), Chen, H.-C. (Heng-Chang), Kuzman, M. (Maja), Zorita, E. (Eduard), Wegner, J. (Julia), Minneker, V. (Vera), Wang, W. (Wei), Fronza, R. (Raffaele), Laufs, S. (Stefanie), Schmidt, M. (Manfred), Stadhouders, R. (Ralph), Roukos, V. (Vassilis), Vlahovicek, K. (Kristian), Filion, G.J. (Guillaume J.), and Lusic, M. (Marina)

Abstract

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for HIV-1 integration have so far remained unclear. Here we show that recurrently targeted genes are proximal to super-enhancer genomic elements and that they cluster in specific spatial compartments of the T cell nucleus. We further show that these gene clusters acquire their location during the activation of T cells. The clustering of these genes along with their transcriptional activity are the major determinants of HIV-1 integration in T cells. Our results provide evidence of the relevance of the spatial compartmentalization of the genome for HIV-1 integration, thus further strengthening the role of nuclear architecture in viral infection.

Published
2019
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175. Ion irradiation induced element-enriched and depleted nanostructures in Zr-Al-Cu-Ni metallic glass.

Author

Chen, H. C., Cao, G. Q., Liu, R. D., Wang, G., Yan, L., and Zhou, X. T.

Subjects
*IRRADIATION, *PHOTODESORPTION, *ZIRCONIUM, *ZIRCONIUM compounds, *NANOSTRUCTURES
Abstract

The microstructural evolution of a Zr-Al-Cu-Ni metallic glass induced by irradiation with Ar ions was investigated. Under ion irradiation, the Cu- and Ni-enriched nanostructures (diameter of 30-50 nm) consisted of crystalline and amorphous structures were formed. Further, Cu- and Ni-depleted nanostructures with diameters of 5-20 nm were also observed. The formation of these nanostructures can be ascribed to the migration of Cu and Ni atoms in the irradiated metallic glass. [ABSTRACT FROM AUTHOR]

Published
2015
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197. Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines – Multi-country assessment

Author

Weibel, D.M. (Daniel), Sturkenboom, M.C.J.M. (Miriam), Black, S. (Steve), Ridder, M.A.J. (Maria) de, Dodd, C.N. (Caitlin), Bonhoeffer, J. (Jan), Vanrolleghem, A.M. (Ann M.), Maas, N.A.T. (Nicoline) van der, Lammers, G.J. (Gert Jan), Overeem, S. (Sebastiaan), Gentile, A. (Angela), Giglio, N. (Norberto), Castellano, V. (Vanesa), Kwong, J.C. (Jeffrey C.), Murray, B.J. (Brian J.), Cauch-Dudek, K. (Karen), Juhasz, D. (Diana), Campitelli, M. (Michael), Datta, A.N. (Alexandre N.), Kallweit, U. (Ulf), Huang, W.-T. (Wan-Ting), Huang, Y.-S. (Yu-Shu), Hsu, C.-Y. (Chung-Yao), Chen, H.-C. (Hsi-Chung), Giner-Soriano, M. (Maria), Morros, R. (Rosa), Gaig, C., Tió, E. (Ester), Pérez-Vilar, S. (Silvia), Díez-Domingo, J. (Javier), Puertas, F.J. (Francisco Javier), Svenson, L.W. (Lawrence W.), Mahmud, S.M. (Salaheddin M.), Carleton, B. (Bruce), Naus, M. (Monika), Arnheim-Dahlström, L. (Lisen), Pedersen, L. (Lars), DeStefano, F. (Frank), Shimabukuro, T. (Tom), Weibel, D.M. (Daniel), Sturkenboom, M.C.J.M. (Miriam), Black, S. (Steve), Ridder, M.A.J. (Maria) de, Dodd, C.N. (Caitlin), Bonhoeffer, J. (Jan), Vanrolleghem, A.M. (Ann M.), Maas, N.A.T. (Nicoline) van der, Lammers, G.J. (Gert Jan), Overeem, S. (Sebastiaan), Gentile, A. (Angela), Giglio, N. (Norberto), Castellano, V. (Vanesa), Kwong, J.C. (Jeffrey C.), Murray, B.J. (Brian J.), Cauch-Dudek, K. (Karen), Juhasz, D. (Diana), Campitelli, M. (Michael), Datta, A.N. (Alexandre N.), Kallweit, U. (Ulf), Huang, W.-T. (Wan-Ting), Huang, Y.-S. (Yu-Shu), Hsu, C.-Y. (Chung-Yao), Chen, H.-C. (Hsi-Chung), Giner-Soriano, M. (Maria), Morros, R. (Rosa), Gaig, C., Tió, E. (Ester), Pérez-Vilar, S. (Silvia), Díez-Domingo, J. (Javier), Puertas, F.J. (Francisco Javier), Svenson, L.W. (Lawrence W.), Mahmud, S.M. (Salaheddin M.), Carleton, B. (Bruce), Naus, M. (Monika), Arnheim-Dahlström, L. (Lisen), Pedersen, L. (Lars), DeStefano, F. (Frank), and Shimabukuro, T. (Tom)

Abstract

Background: In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent pandemic H1N1 influenza (pH1N1) vaccine. To further assess a possible association and inform policy on future use of adjuvants, we conducted a multi-country study of narcolepsy and adjuvanted pH1N1 vaccines. Methods: We used electronic health databases to conduct a dynamic retrospective cohort study to assess narcolepsy incidence rates (IR) before and during pH1N1 virus circulation, and after pH1N1 vaccination campaigns in Canada, Denmark, Spain, Sweden, Taiwan, the Netherlands, and the United Kingdom. Using a case-control study design, we evaluated the risk of narcolepsy following AS03- and MF59-adjuvanted pH1N1 vaccines in Argentina, Canada, Spain, Switzerland, Taiwan, and the Netherlands. In the Netherlands, we also conducted a case-coverage study in children born between 2004 and 2009. Results: No changes in narcolepsy IRs were observed in any periods in single study sites except Sweden and Taiwan; in Taiwan incidence increased after wild-type pH1N1 virus circulation and in Sweden (a previously identified signaling country), incidence increased after the start of pH1N1 vaccination. No association was observed for Arepanrix-AS03 or Focetria-MF59 adjuvanted pH1N1 vaccines and narcolepsy in children or adults in the case-control study nor for children born between 2004 and 2009 in the Netherlands case-coverage study for Pandemrix-AS03. Conclusions: Other than elevated narcolepsy IRs in the period after vaccination campaigns in Sweden, we did not find an association between AS03- or MF59-adjuvanted pH1N1 vaccines and narcolepsy in children or adults in the sites studied, although power to evaluate the AS03-adjuvanted Pandemrix brand vaccine was limited in our study.

Published
2018
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198. Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder

Author

Reinbold, CS, Forstner, AJ, Hecker, J, Fullerton, JM, Hoffmann, P, Hou, L, Heilbronner, U, Degenhardt, F, Adli, M, Akiyama, K, Akula, N, Ardau, R, Arias, B, Backlund, L, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Marie-Claire, C, Cervantes, P, Chen, G-B, Chen, H-C, Chillotti, C, Clark, SR, Colom, F, Cousins, DA, Cruceanu, C, Czerski, PM, Dayer, A, Etain, B, Falkai, P, Frisen, L, Gard, S, Garnham, JS, Goes, FS, Grof, P, Gruber, O, Hashimoto, R, Hauser, J, Herms, S, Jamain, S, Jimenez, E, Kahn, J-P, Kassem, L, Kittel-Schneider, S, Kliwicki, S, Koenig, B, Kusumi, I, Lackner, N, Laje, G, Landen, M, Lavebratt, C, Leboyer, M, Leckband, SG, Lopez Jaramillo, CA, MacQueen, G, Manchia, M, Martinsson, L, Mattheisen, M, McCarthy, MJ, McElroy, SL, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Osby, U, Ozaki, N, Perlis, RH, Pfennig, A, Reich-Erkelenz, D, Rouleau, GA, Schofield, PR, Schubert, KO, Schweizer, BW, Seemueller, F, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Smoller, JW, Squassina, A, Stamm, TJ, Stopkova, P, Tighe, SK, Tortorella, A, Turecki, G, Volkert, J, Witt, SH, Wright, AJ, Young, LT, Zandi, PP, Potash, JB, DePaulo, JR, Bauer, M, Reininghaus, E, Novak, T, Aubry, J-M, Maj, M, Baune, BT, Mitchell, PB, Vieta, E, Frye, MA, Rybakowski, JK, Kuo, P-H, Kato, T, Grigoroiu-Serbanescu, M, Reif, A, Del Zompo, M, Bellivier, F, Schalling, M, Wray, NR, Kelsoe, JR, Alda, M, McMahon, FJ, Schulze, TG, Rietschel, M, Nothen, MM, Cichon, S, Reinbold, CS, Forstner, AJ, Hecker, J, Fullerton, JM, Hoffmann, P, Hou, L, Heilbronner, U, Degenhardt, F, Adli, M, Akiyama, K, Akula, N, Ardau, R, Arias, B, Backlund, L, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Marie-Claire, C, Cervantes, P, Chen, G-B, Chen, H-C, Chillotti, C, Clark, SR, Colom, F, Cousins, DA, Cruceanu, C, Czerski, PM, Dayer, A, Etain, B, Falkai, P, Frisen, L, Gard, S, Garnham, JS, Goes, FS, Grof, P, Gruber, O, Hashimoto, R, Hauser, J, Herms, S, Jamain, S, Jimenez, E, Kahn, J-P, Kassem, L, Kittel-Schneider, S, Kliwicki, S, Koenig, B, Kusumi, I, Lackner, N, Laje, G, Landen, M, Lavebratt, C, Leboyer, M, Leckband, SG, Lopez Jaramillo, CA, MacQueen, G, Manchia, M, Martinsson, L, Mattheisen, M, McCarthy, MJ, McElroy, SL, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Osby, U, Ozaki, N, Perlis, RH, Pfennig, A, Reich-Erkelenz, D, Rouleau, GA, Schofield, PR, Schubert, KO, Schweizer, BW, Seemueller, F, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Smoller, JW, Squassina, A, Stamm, TJ, Stopkova, P, Tighe, SK, Tortorella, A, Turecki, G, Volkert, J, Witt, SH, Wright, AJ, Young, LT, Zandi, PP, Potash, JB, DePaulo, JR, Bauer, M, Reininghaus, E, Novak, T, Aubry, J-M, Maj, M, Baune, BT, Mitchell, PB, Vieta, E, Frye, MA, Rybakowski, JK, Kuo, P-H, Kato, T, Grigoroiu-Serbanescu, M, Reif, A, Del Zompo, M, Bellivier, F, Schalling, M, Wray, NR, Kelsoe, JR, Alda, M, McMahon, FJ, Schulze, TG, Rietschel, M, Nothen, MM, and Cichon, S

Abstract

Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs. However, it is unknown whether these miRNAs are also associated with lithium response in BD. In the present study, we therefore tested whether common variants at these nine candidate miRNAs contribute to the variance in lithium response in BD. Furthermore, we systematically analyzed whether any other miRNA in the genome is implicated in the response to lithium. For this purpose, we performed gene-based tests for all known miRNA coding genes in the ConLiGen GWAS dataset (n = 2,563 patients) using a set-based testing approach adapted from the versatile gene-based test for GWAS (VEGAS2). In the candidate approach, miR-499a showed a nominally significant association with lithium response, providing some evidence for involvement in both development and treatment of BD. In the genome-wide miRNA analysis, 71 miRNAs showed nominally significant associations with the dichotomous phenotype and 106 with the continuous trait for treatment response. A total of 15 miRNAs revealed nominal significance in both phenotypes with miR-633 showing the strongest association with the continuous trait (p = 9.80E-04) and miR-607 with the dichotomous phenotype (p = 5.79E-04). No association between miRNAs and treatment response to lithium in BD in either of the tested conditions withstood multiple testing correction. Given the limited power of our study, the investigation of miRNAs

Published
2018

199. PERI-OPERATIVE ANALGESIC EFFICACY OF TRAMADOL IN DOGS AND CATS.

Author

CHEN, H. C., ONG, B. H. E., and KAKA, U.

Subjects
TRAMADOL, HYSTERO-oophorectomy, ANALGESICS, DOGS
Abstract

Tramadol, classified as an 'atypical opioid', is a centrally acting analgesic that is easily available in injectable and oral preparations in Malaysia. Queries on its use and efficacy to manage pain in small animal practice prompted this review. Following tramadol administration in dogs, there is lack of sedation and opioid effects when compared to cats. This may likely due to species difference in the production, metabolism and elimination of O-desmethyltramadol (M1). Good efficacy of tramadol was reported in both dogs and cats undergoing ovariohysterectomy and castration. Preemptive doses were administered via parenteral routes between 2 -- 4 mg/kg, usually during premedication or after induction. Adequate pain control was reported with tramadol 2 mg/kg, SC every 8 hours following maxillectomy or mandibulectomy in dogs. Thus, adequate analgesia can be promoted with increase doses or repeated parenteral dosing following orthopaedic procedures. Repeated oral doses of tramadol as the sole analgesic were found to be less effective in dogs undergoing tibia plateau levelling osteotomy. Combinations of tramadol and a non-steroidal anti-inflammatory drug were found to provide better post-operative analgesia in both dogs and cats. [ABSTRACT FROM AUTHOR]

Published
2020

200. Aging increases cell-to-cell transcriptional variability upon immune stimulation

Author

Martinez-Jimenez, CP, Eling, N, Chen, H-C, Vallejos, CA, Kolodziejczyk, AA, Connor, F, Stojic, L, Rayner, TF, Stubbington, MJT, Teichmann, SA, de la Roche, M, Marioni, JC, Odom, DT, Chen, Hung-Chang [0000-0002-2849-6752], Connor, Frances [0000-0003-2858-9411], Teichmann, Sarah [0000-0002-6294-6366], de la Roche, Maike [0000-0002-0558-4119], Marioni, John [0000-0001-9092-0852], Odom, Duncan [0000-0001-6201-5599], and Apollo - University of Cambridge Repository

Subjects
CD4-Positive T-Lymphocytes, Male, Aging, Sequence Analysis, RNA, Receptors, Antigen, T-Cell, Genetic Variation, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Animals, Single-Cell Analysis, Transcriptome, Immunologic Memory, Cellular Senescence
Abstract

Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA sequencing of unstimulated and stimulated naïve and effector memory CD4(+) T cells from young and old mice from two divergent species. In young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up-regulation of a core activation program, coupled with a decrease in cell-to-cell variability. Aging perturbed the activation of this core program and increased expression heterogeneity across populations of cells in both species. These discoveries suggest that increased cell-to-cell transcriptional variability will be a hallmark feature of aging across most, if not all, mammalian tissues.

Published
2017

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