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What do you know when you know what a sentence means? According to some theories, understanding a sentence is, in part, knowing its truth-conditions. Dorit Bar-On, Claire Horisk, and William Lycan have defended such theories on the grounds of an “epistemic determination argument” (“EDA”). That argument turns on the ideas (a) that understanding a sentence, along with knowledge of the non-linguistic facts, suffices to know its truth-value, and (b) that being able to determine a sentence’s truth-value given knowledge of the non-linguistic facts is knowing its truth-conditions. I argue that the EDA withstands the objections recently raised by Daniel Cohnitz and Jaan Kangilaski, but fails for other reasons. It equivocates between a fine-grained and a coarse grained conception of “facts.”

Coagulation transglutaminase factor XIII (FXIII) exists in circulation as heterotetrameric proenzyme FXIII-A2B2 Effectively all FXIII-A2B2 circulates bound to fibrinogen, and excess FXIII-B2 circulates in plasma. The motifs that mediate interaction of FXIII-A2B2 with fibrinogen have been elusive. We recently detected reduced binding of FXIII-A2B2 to murine fibrinogen that has γ-chain residues 390-396 mutated to alanines (Fibγ390-396A). Here, we evaluated binding features using human components, including recombinant fibrinogen variants, FXIII-A2B2, and isolated FXIII-A2 and -B2 homodimers. FXIII-A2B2 coprecipitated with wild-type (γA/γA), alternatively-spliced (γ'/γ'), and αC-truncated (Aα251) fibrinogens, whereas coprecipitation with human Fibγ390-396A was reduced by 75% (P

The trend amongst many parties toward the inclusion of rank-and-file members in the leadership selection process has often been attributed to opposition status and electoral defeat. However, these explanations are typical events for parties and hardly seem sufficient for party elites to willingly cede their authority over the selection of party leaders. This paper proposes that the electoral regionalization of the party contributes to the decision to expand the leadership selectorate. In the event a party is defeated to an extent in which their support is reduced to its regional base, this situation necessitates the bringing in of new voices to avoid further marginalization. This paper finds that regionalization plays a significant role in the decision of parties to expand leadership selectorates and that the role of opposition status and electoral setbacks have been overstated.

Objective Minority candidates for office must overcome numerous hurdles in order to win elective office, with one such hurdle being the racial resentment of voters. This article tests the impact racial resentment has on white support for a minority candidate in relation to a similar white candidate. Method This article employs a natural experiment provided by the 2014 South Carolina Senate elections. Examining these elections, this article examines what impact a voter's racial resentment has on his or her support for the two candidates. Results The results show that voters who score highly on the racial resentment scale are just as likely to support a minority Republican as they are to support a white Republican. Conclusion These findings indicate that racial resentment scores may not adequately measure a person's true feelings on race, particularly when the minority candidate is a Republican.

Key points Using whole-cell clamp methods, we characterized the temporal coding in each type of OFF bipolar cell. We found that type 2 and 3a cells are transient, type 1 and 4 cells are sustained, and type 3b cells are intermediate. The light-evoked excitatory postsynaptic potentials in some types were rectified, suggesting that they provide inputs to the non-linear ganglion cells. Visual signalling from the photoreceptors was mediated exclusively through the kainate receptors in the transient OFF bipolar cells, whereas both kainate and AMPA receptors contributed in the other cells. This study demonstrates, for the first time, that parallel visual encoding starts at the OFF bipolar cells in a type-specific manner. Abstract The retina is the entrance to the visual system, which receives various kinds of image signals and forms multiple encoding pathways. The second-order retinal neurons, the bipolar cells, are thought to initiate multiple neural streams by encoding various visual signals in different types of cells. However, the functions of each bipolar cell type have not been fully understood. We investigated whether OFF bipolar cells encode visual signals in a type-dependent manner. We recorded the changes in the bipolar cell voltage in response to two input functions: step and sinusoidal light stimuli. Type 1 and 4 OFF bipolar cells were sustained cells and responded to sinusoidal stimuli over a broad range of frequencies. Type 2 and 3a cells were transient and exhibited band-pass filtering. Type 3b cells were in the middle of these two groups. The distinct temporal responses might be attributed to different types of glutamate receptors. We examined the AMPA and kainate glutamate receptor composition in each bipolar cell type. The light responses in the transient OFF bipolar cells were exclusively mediated by kainate receptors. Although the kainate receptors mediated the light responses in the sustained cells, the AMPA receptors also mediated a portion of the responses in sustained cells. Furthermore, we found that some types of cells were rectified more than other types. Taken together, we found that the OFF bipolar cells encode diverse temporal image signals in a type-dependent manner, confirming that each type of OFF bipolar cell initiates diverse temporal visual processing in parallel.

Introduction Sleep dysfunction in patients with rotator cuff tears has been previously evaluated only using subjective measures. Objective parameters of sleep quality amongst rotator cuff tear patients are scarce in the literature. The aim of this study is to compare objective sleep data to historical controls and to subjective patient reported sleep quality in patients with rotator cuff tears. Hypothesis We hypothesized that patients with rotator cuff tears would demonstrate objectively poor sleep quality based on actigraphy when compared to a historical control group. Secondarily, we hypothesize that objective sleep quality measures will correlate poorly with traditionally used questionnaires and other subjective assessments. Materials and methods Twenty patients with full-thickness rotator cuff tears wore a highly validated activity monitor for 2 consecutive weeks for objective assessment and completed a sleep diary during the same period. Patients completed multiple questionnaires pertaining to their shoulder function and subjective assessment of sleep quality. Objective sleep assessments were compared to patients’ sleep diary data and to subjective sleep data from a historical cohort of 969 healthy adults aged 57–97 years. Results Mean total sleep time, sleep onset latency, wake after sleep onset (WASO), and sleep efficiency were all significantly worse in the study cohort compared to the historical cohort (p = 0.0338, p = 0.0040, p Discussion This study of objective sleep measures demonstrated poor sleep quality in patients with rotator cuff tears with shorter sleep duration, frequent awakenings, and decreased efficiency. Subjective assessments of sleep did not correlate with objective findings. Level of evidence Level II, prospective cohort study.

Background and aims Apios priceana is a rare flowering plant that can only be found in parts of the Southeastern United States. Little is known about the reproductive biology of this plant and only a

The North American monarch butterfly (Danaus plexippus) population has declined significantly over the past two decades. Among the many other factors, loss of breeding habitat has been implicated as a potential leading driver. In response, wildlife agencies and conservation practitioners have made a strong push to restore and conserve milkweeds on both wild and managed landscapes including agricultural lands as well as transportation and utility rights-of-way. Roadsides in particular have been emphasized as a targeted landscape for monarch habitat restoration. While much attention has been focused on habitat in California, along the I-35 corridor from Texas to Minnesota, and more broadly across the agricultural Midwest, research on the occurrence of roadside breeding habitat and the development of best vegetative management practices conducted in the Deep South has been limited. We sampled roadside verges in north-central Florida for the presence of two early season milkweed species, that are particularly important for early season monarch recolonization, Asclepias tuberosa and Asclepias humistrata. Our findings suggest that roadsides harbor extensive populations of the target milkweeds with the vast majority of plants occurring on the back slope of the verge. Alterations to current roadside mowing frequency and scope are needed to effectively conserve these populations and ensure that they are available for use by the monarch.

Peptide-polymer hybrids combine the hierarchy of biological species with synthetic concepts to achieve control over molecular design and material properties. By further incorporating covalent cross-links, the enhancement of molecular complexity is achieved, allowing for both a physical and covalent network. In this work, the structure and function of poly(ethylene glycol) (PEG)-network hybrids are tuned by varying peptide block length and overall peptide content. Here the impact of poly(ε-carbobenzyloxy-l-lysine) (PZLY) units on block interactions and mechanics is explored by probing secondary structure, PEG crystallinity, and hierarchical organization. The incorporation of PZLY reveals a mixture of α-helices and β-sheets at smaller repeat lengths ( n = 5) and selective α-helix formation at a higher peptide molecular weight ( n = 20). Secondary structure variations tailored the solid-state film hierarchy, whereby nanoscale fibers and microscale spherulites varied in size depending on the amount of α-helices and β-sheets. This long-range ordering influenced mechanical properties, resulting in a decrease in elongation-at-break (from 400 to 20%) with increasing spherulite diameter. Furthermore, the reduction in soft segment crystallinity with the addition of PZLY resulted in a decrease in moduli. It was determined that, by controlling PZLY content, a balance of physical associations and self-assembly is obtained, leading to tunable PEG crystallinity, spherulite formation, and mechanics.

Retinal first-order neurons, photoreceptors, receive visual inputs and convert them to neural signals. The second-order neurons, bipolar cells then sort out the visual signals and encode them through multiple neural streams. Approximately 15 morphological types of bipolar cells have been identified, which are thought to encode different aspects of visual signals such as motion and color (Ichinose et al. J Neurosci 34(26):8761-8771, 2014; Euler et al. Nat Rev Neurosci 15(8):507-519, 2014). To investigate functional aspects of OFF bipolar cells, single cell recordings are preferred; however, bipolar cells in the mouse retina are small and hard to distinguish from other types of cells. Here, we describe our methodology and tips for immunohistochemistry and patch clamp recordings for analyzing light-evoked responses in each type of OFF bipolar cell.

The canonical mGluR6‐Trpm1 pathway that generates the sign‐inverting signal between photoreceptors and ON bipolar cells has been well described. However, one type of ON bipolar cell, the rod bipolar cell (RBC), additionally is thought to express the group I mGluRs whose function is unknown. We examined the role of group I mGluRs in mouse RBCs and here provide evidence that it controls synaptic gain between rods and RBCs. In dark‐adapted conditions, the mGluR1 antagonists LY367385 and (RS)‐1‐Aminoindan‐1,5‐dicarboxylic acid, but not the mGluR5 antagonist 2‐Methyl‐6‐(phenylethynyl)pyridine hydrochloride reduced the light‐evoked responses in RBCs indicating that mGluR1, but not mGluR5, serves to potentiate RBC responses. Perturbing the downstream phospholipase C (PLC)‐protein kinase C (PKC) pathway by inhibiting PLC, tightly buffering intracellular Ca2+, or preventing its release from intracellular stores reduced the synaptic potentiation by mGluR1. The effect of mGluR1 activation was dependent upon adaptation state, strongly increasing the synaptic gain in dark‐, but not in light‐adapted retinas, or in the presence of a moderate background light, consistent with the idea that mGluR1 activation requires light‐dependent glutamate release from rods. Moreover, immunostaining revealed that protein kinase Cα (PKC α) is more strongly expressed in RBC dendrites in dark‐adapted conditions, revealing an additional mechanism behind the loss of mGluR1 potentiation. In light‐adapted conditions, exogenous activation of mGluR1 with the agonist 3,5‐Dihydroxyphenylglycine increased the mGluR6 currents in some RBCs and decreased it in others, suggesting an additional action of mGluR1 that is unmasked in the light‐adapted state. Elevating intracellular free Ca2+, consistently resulted in a decrease in synaptic gain. Our results provide evidence that mGluR1 controls the synaptic gain in RBCs.

Chase B Ansok, Stephanie J Muh Department of Orthopaedic Surgery, Henry Ford Hospital, Detroit, MI, USA Abstract: Glenohumeral osteoarthritis (OA) is defined as progressive loss of articular cartilage, resulting in bony erosion, pain, and decreased function. This article provides a gross overview of this disease, along with peer-reviewed research by experts in the field. The pathology, diagnosis, and classification of this condition have been well described. Treatment begins with non-operative measures, including oral and topical anti-inflammatory agents, physical therapy, and intra-­articular injections of either a corticosteroid or a viscosupplementation agent. Operative treatment is based on the age and function of the affected patient, and treatment of young individuals with glenohumeral OA remains controversial. Various methods of surgical treatment, ranging from arthroscopy to resurfacing, are being evaluated. The roles of hemiarthroplasty, total shoulder arthroplasty, and reverse shoulder arthroplasty are similarly reviewed with supporting data. Keywords: glenohumeral, osteoarthritis, hyaluronic acid, hemiarthroplasty, total shoulder arthroplasty

In 2016, Hillary Clinton was the first woman to gain the presidential nomination from a major political party in the United States, yet she was unsuccessful. The current study explores barriers to being elected as president for women generally and Hillary Clinton specifically. Using the propositions and tools of affect control theory, we demonstrate how women’s political representation shapes cultural sentiments about women and the president. In a nationwide sample of Americans surveyed shortly before the election, we find women’s representation on the state level influences voter preferences through these cultural sentiments: More women in politics makes a woman president feel less deflecting, which is associated with a greater likelihood of voting for Clinton. We also demonstrate how sentiments about Clinton—as an individual, not merely a woman running for president—conflict with Democratic voters’ expectations for presidential qualities and behaviors, which may have further prevented victory in 2016. OASF

The problem of mixed inferences is a bugbear for alethic pluralism and logical pluralism alike. Michael Lynch’s alethic functionalism is meant to solve the problem for alethic pluralists. But, as Lynch observes, it is tempting to combine alethic and logical pluralism, and doing so threatens to reintroduce the problem. Lynch proposes a way out of the problem for alethic cum logical pluralists. I argue that Lynch’s way out is a dead end, and the combination of logical and alethic pluralism is unattractive.

BACKGROUND CONTEXT Improving value in surgical care requires a detailed understanding of the true costs of surgical and operating room resources. PURPOSE In this study, we sought to identify predictors of health care costs and operating room resource use for patients undergoing initial single-level discectomies using a unique institutional cost dataset from the value driven outcomes (VDO) program developed by the University of Utah. STUDY DESIGN/SETTING A retrospective cost analysis of primary single-level lumbar discectomies. PATIENT SAMPLE A total of 622 patients undergoing initial single-level lumbar discectomy between January 2014 to April 2016 at the University of Utah Orthopaedic Center. OUTCOME MEASURES Health care costs, clinical length of stay, and operating room time. METHODS Univariate and multivariate generalized linear models (GLM) performed to identify predictors of health care costs, clinical length of stay (LOS, days) and operating room time (OR, minutes) using a unique costing tool. Modified park test procedure was implemented to determine GLM error distribution specifications and standard errors were clustered by provider. Cost outcomes were normalized using mean costs for a patient with normal body mass index (BMI) and a healthy American Society of Anesthesiologists (ASA) classification system. Average marginal effects in multivariate analysis were reported as percentage of normalized costs. RESULTS Advanced age, male gender, Hispanic, Black, unemployment, and being retired were significant positive predictors of costs in univariate analysis. Asian, Native American, outpatient procedures, and being a student were significant negative predictors of costs. Univariate analysis also showed that obesity, higher ASA class and insurance status were also positive and significant predictors of costs. In multivariate analysis, we found that obesity led to higher average marginal total direct (9%), total facility (15%), and facility OR costs (22%), as well as an average marginal effect of 24 more OR minutes per surgery. Conversely, being underweight was associated with lower average marginal total direct (-23%), total non-facility (-54%), total facility (-8%), facility OR costs (-15%), as well as lower clinical LOS (-.42 days), and 18 less OR minutes. While being overweight was not significantly associated with greater total direct costs, it was associated with higher total facility (8%), and facility OR costs (12%), with an average marginal effect of 11 more OR minutes per surgery. Age was associated with a longer LOS but not with OR costs in multivariate analysis. As expected, outpatient surgical costs, LOS and OR time were significantly lower than inpatient procedures. Patients with incapacitating disease ASA Class had the highest predicted OR time in GLM estimates with an average marginal effect of 28 minutes, while severe systematic disease was associated with greater total and nonfacility costs. In addition, Medicare patients had higher facility costs (14%) compared to privately insured patients. CONCLUSIONS Although many of our observed variables were significant predictors of costs in univariate analysis, multivariate GLM estimates showed that the main variables determining cost and operating room time and resource use were obesity (BMI), general health (ASA class), Medicare status and advanced age, and whether the surgery was an outpatient or inpatient procedure. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.

Background context The neck disability index (NDI) was the first patient-reported outcome (PRO) instrument specific to patients with neck pain, and it remains one of the most widely used PROs for the neck population. The NDI is an appealing measure as it is a short and well-known PRO measure. Currently, there are conflicting data on the performance and applicability of the NDI in patients undergoing either operative or nonoperative treatment for neck-related conditions. Purpose This study investigates the psychometric properties, performance, and applicability of the NDI in the spine patient population. Study design A total of 865 patients visiting a university-based spine clinic with neck complaints, with or without radiating upper extremity pain, numbness, or weakness were enrolled in the study. Visit types included new and follow-up visits to both operative and nonoperative treatments. Questionnaires were administered electronically on a tablet computer, and all patients answered all 10 questions of the NDI. Methods Standard descriptive statistics were performed to describe the demographic characteristics of the patients. Rasch modeling was applied to examine the psychometric properties of the NDI. Results The NDI demonstrated insufficient unidimensionality (ie, unexplained variance after accounting for the first dimension=9.4%). Person reliability was 0.85 and item reliability was 1.00 for the NDI. The overall item fit for the NDI was good with an outfit mean square of 1.03. The NDI had a floor effect of 35.5% and ceiling effect of 4.6%. The raw score to measure correlation of the NDI was 0.019. Conclusions Although the NDI had good person and item reliability, it did not demonstrate strong evidence of unidimensionality. The NDI exhibited a very large floor effect. Because of the poor raw score to measure correlation, the sum score should not be used in interpretation of findings. Despite great investment by physicians and other stakeholders in the NDI, this evaluation and previous research have demonstrated that the NDI needs further investigation and refinement.

We might suppose it is not only instrumentally valuable for beliefs to be true, but that it is intrinsically valuable – truth makes a non-derivative, positive contribution to a belief's overall value. Some intrinsic goods are better than others, though, and this article considers the question of how good truth is, compared to other intrinsic goods. I argue that truth is the worst of all intrinsic goods; every other intrinsic good is better than it. I also suggest the best explanation for truth's inferiority is that it is not really an intrinsic good at all. It is intrinsically neutral.

The establishment of native wildflower plantings in Florida can benefit agricultural producers as well as native pollinators and other beneficial insects (predators and parasitoids). The plantings do this by: providing forage and nesting sites for bees, butterflies, and other pollinators, increasing wild bee numbers possibly across the farm, and increasing natural enemies of insect pests (that also depend on forage and nesting sites). This document discusses choosing the right mix of native plant species to benefit many pollinator species, as well as proper site selection, planting practices, and weed control techniques. Wildflower plots should be practical to manage, maximize benefits to wildlife, and fit into the overall management practices of the property.

Purpose Motion detection is performed by a unique neural network in the mouse retina. Starburst amacrine cells (SACs), which release acetylcholine and gamma-aminobutyric acid (GABA) into the network, are key neurons in the motion detection pathway. Although GABA contributions to the network have been extensively studied, the role of acetylcholine is minimally understood. Acetylcholine receptors are present in a subset of bipolar, amacrine, and ganglion cells. We focused on α7-nicotinic acetylcholine receptor (α7-nAChR) expression in bipolar cells, and investigated which types of bipolar cells possess α7-nAChRs. Methods Retinal slice sections were prepared from C57BL/6J and Gus8.4-GFP mice. Specific expression of α7-nAChRs in bipolar cells was examined using α-bungarotoxin (αBgTx)-conjugated Alexa dyes co-labeled with specific bipolar cell markers. Whole-cell recordings were conducted from bipolar cells in retinal slice sections. A selective α7-nAChR agonist, PNU282987, was applied by a puff and responses were recorded. Results αBgTx fluorescence was observed primarily in bipolar cell somas. We found that α7-nAChRs were expressed by the majority of type 1, 2, 4, and 7 bipolar cells. Whole-cell recordings revealed that type 2 and 7 bipolar cells depolarized by PNU application. In contrast, α7-nAChRs were not detected in most of type 3, 5, 6, and rod bipolar cells. Conclusions We found that α7-nAChRs are present in bipolar cells in a type-specific manner. Because these bipolar cells provide synaptic inputs to SACs and direction selective ganglion cells, α7-nAChRs may play a role in direction selectivity by modulating these bipolar cells' outputs.