506 results on '"Castro Henriques"'
Search Results
152. Constructive-geometry:the integration of generation and construction systems in a case-study
- Author
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Regadas Reis Vianna, Maria Elisa, additional, Castro Henriques, Gonçalo, additional, and Martin Passaro, Andrés, additional
- Published
- 2018
- Full Text
- View/download PDF
153. Impact ofde novodonor-specific anti-HLA antibodies on grafts outcomes in simultaneous pancreas-kidney transplantation
- Author
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Sandra Tafulo, António Castro-Henriques, Idalina Beirão, António Cabrita, La Salete Martins, Leonídio Dias, Isabel Fonseca, and Jorge Malheiro
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,030232 urology & nephrology ,Human leukocyte antigen ,030230 surgery ,Pancreas transplantation ,Gastroenterology ,Isoantibodies ,03 medical and health sciences ,0302 clinical medicine ,HLA Antigens ,Internal medicine ,medicine ,Humans ,Kidney transplantation ,Transplantation ,Type 1 diabetes ,Kidney ,biology ,business.industry ,Histocompatibility Testing ,Graft Survival ,HLA-DR Antigens ,medicine.disease ,Kidney Transplantation ,Tissue Donors ,Logistic Models ,medicine.anatomical_structure ,Immunology ,biology.protein ,Female ,Pancreas Transplantation ,Antibody ,business - Abstract
De novo donor-specific antibodies (dDSA) relevance in simultaneous pancreas-kidney (SPK) transplantation has been scarcely investigated. We analyzed dDSA relationship with grafts outcomes in a long-term follow-up SPK-transplanted cohort. In 150 patients that received SPK transplant between 2000 and 2013, post-transplant anti-human leukocyte antigen (HLA) antibodies were screened and identified using Luminex-based assays in sera collected at 3, 6, and 12 months, then yearly. dDSA were detected in 22 (14.7%) patients at a median 3.1 years after transplant. Pretransplant anti-HLA sensitization (OR = 4.64), full HLA-DR mismatch (OR = 4.38), and previous acute cellular rejection (OR = 9.45) were significant risk factors for dDSA. dDSA were significantly associated with kidney (in association with acute rejection) and pancreas graft failure. In dDSA+ patients, those with at least one graft failure presented more frequently dDSA against class II or I + II (P = 0.011) and locusDQ (P = 0.043) and had a higher median dDSA number (P = 0.014) and strength (P = 0.030). Median time between dDSA emergence and pancreas and kidney graft failure was 5 and 12 months, respectively. Emergence of dDSA increased the risk of grafts failure in SPK-transplanted patients. Full HLA-DR mismatch was associated with dDSA emergence. dDSA characteristics might help identify patients at a higher risk of graft failure.
- Published
- 2015
154. Changes in bone mineral density following long-term simultaneous pancreas-kidney transplantation
- Author
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Jorge Malheiro, La Salete Martins, Clara Santos, Ana Rocha, Castro Henriques, and Jorge Dores
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Adult ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Time Factors ,Bone density ,Bone disease ,Prednisolone ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,030232 urology & nephrology ,Urology ,030209 endocrinology & metabolism ,Lumbar vertebrae ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Bone Density ,Risk Factors ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femoral neck ,Bone mineral ,Lumbar Vertebrae ,Femur Neck ,business.industry ,General Medicine ,medicine.disease ,Kidney Transplantation ,Surgery ,Transplantation ,Logistic Models ,medicine.anatomical_structure ,Multivariate Analysis ,Female ,Pancreas Transplantation ,business ,Densitometry ,Biomarkers - Abstract
The symptoms of chronic renal disease-related mineral and bone disease improve significantly in patients after successful simultaneous pancreas-kidney transplantation (SPKT); however, bone pathology is still present even after many post-transplant years. The aim of this study was to analyze the bone densitometry in different periods after SPKT. Three-point densitometry was performed with the dual-energy X-ray absorptiometry (DXA) technique. Serum levels of alkaline phosphatase (ALP), total serum calcium, phosphate and parathyroid hormone were analyzed as markers of mineral metabolism. The study population consisted of 48 patients (28 females, 20 males) with a mean age of 35 ± 6 years and mean 24 ± 6 years of prior diabetes. Mean period of maintenance dialysis was 36 ± 26 months. The median time from SPKT and DXA measurement was 0.53, 26.2 and 41.9 months, respectively. Based on the DXA technique, 35.4 % of patients were categorized as having osteoporosis at the lumbar spine and 39.6 % at the femoral neck. Patients with diagnosed osteoporosis had significantly higher levels of ALP (OR = 1.5; 95 % CI = 1.1–2.2; p < 0.05 at the lumbar spine; OR = 1.4; 95 % CI = 1.0–1.9; p < 0.05 at the femoral neck). In addition, subjects with lumbar osteoporosis were characterized by a significantly lower body mass index (BMI) (OR = 0.5; 95 % CI = 0.3–0.9; p < 0.05). In the long-term follow-up, BMD increased significantly at the lumbar spine (T-score −1.86 ± 1.07 to −1.08 ± 0.89) and femoral neck (T-score −2.12 ± 0.78 to −1.63 ± 0.65). A multivariate linear model identified a BMI increase as a significant factor associated with improvement in BMD. Results of our study led us to conclude that, according to three-point densitometry, BMD among patients with functioning kidney and pancreas grafts improved. Increased serum levels of ALP were significantly associated with a decrease in BMD, suggesting a higher risk of osteoporosis. BMI gain was predictive of BMD improvement.
- Published
- 2015
155. CT-based renal volume and graft function after living-donor kidney transplantation: Is there a volume threshold to avoid?
- Author
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Leonídio Dias, António Castro-Henriques, Luís Xambre, La Salete Martins, Manuela Guedes de Almeida, Jorge Malheiro, Miguel Silva-Ramos, and Jorge Dias
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Adult ,Male ,Nephrology ,medicine.medical_specialty ,Tissue and Organ Procurement ,Urology ,Renal function ,Kidney Volume ,Kidney ,Young Adult ,Internal medicine ,Living Donors ,medicine ,Humans ,Kidney transplantation ,Retrospective Studies ,business.industry ,Graft Survival ,Retrospective cohort study ,Mathematical Concepts ,Organ Size ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Surgery ,Transplantation ,medicine.anatomical_structure ,Female ,Tomography, X-Ray Computed ,business ,Follow-Up Studies ,Glomerular Filtration Rate - Abstract
Donated kidney volume influences post-transplant outcomes and graft survival. We evaluated the relationship between living-donor kidney volume and recipient graft function at 12 months post-transplantation, exploring a volume threshold for a suboptimal graft function, and compared two different formulas of volume estimation. A retrospective analysis of 82 pairs of living-donor kidney transplants was conducted. Donor renal volumes were estimated from computerized tomography scans using the ellipsoid formula and the voxel counting technique. Linear and restricted cubic regression spline was used to analyze the association of volume with graft function. Additionally, we determined the correlation between the two volume estimation formulas and established a correction factor for the ellipsoid formula. Renal volume (adjusted to recipient BSA) had the strongest independent effect (B = 1.65 per 10 ml/m2 increase, p value
- Published
- 2015
156. Following the Natural History Of A Probable Adrenoleukodystrophy Case And Literature Review
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Arielle Kirmse, André Palma Matta, Pedro S. Morales, Ommega Internationals, A.C.A.F. Ferreira, Osvaldo Jm Nascimento, Marco Orsini, Cristina de Almeida Pereira, Jano Alves de Souza, Karina Magalhães de Castro Henriques, Henrique Cal, Marco Antonio Araújo Leite, and Joao Dib
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Natural history ,Pediatrics ,medicine.medical_specialty ,business.industry ,medicine ,Adrenoleukodystrophy ,medicine.disease ,business - Published
- 2015
157. Analysis of preformed donor-specific anti-HLA antibodies characteristics for prediction of antibody-mediated rejection in kidney transplantation
- Author
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Isabel Fonseca, Sandra Tafulo, Idalina Beirão, António Castro-Henriques, António Cabrita, La Salete Martins, Jorge Malheiro, and Leonídio Dias
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Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Globulin ,Basiliximab ,Immunology ,Human leukocyte antigen ,Gastroenterology ,Disease-Free Survival ,HLA Antigens ,Isoantibodies ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Kidney transplantation ,Transplantation ,Kidney ,biology ,business.industry ,Donor specific antibodies ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Survival Rate ,body regions ,medicine.anatomical_structure ,Antibody mediated rejection ,biology.protein ,Female ,Antibody ,business ,medicine.drug - Abstract
Background The relevance of preformed donor specific antibodies (DSA) detected by Luminex assays, with a negative complement-dependent cytotoxicity (CDC) crossmatch, remains unsettled in kidney transplantation (KT). We aimed to analyze the impact of preformed DSA characteristics on kidney graft outcomes. Methods In 462 patients that received a kidney graft in our unit, between 2007 and 2012, pre-transplant sera were analyzed by Luminex screening assay to determine the presence of anti-human leukocyte antigen (HLA) antibodies and single-antigen bead assay [positive if mean fluorescence intensity (MFI) ≥ 1000] to assign anti-HLA specificities. Results Anti-HLA antibodies were present in 95 patients (20.6%), but only 40 (8.7%) had DSA. Antibody-mediated rejection (AMR) at 1-year was higher in patients with DSA (35.0%) than in those without them (0.9%) (P 3000 were significantly associated with AMR occurrence. Receiver operator curves revealed that a MFI of > 4900 in the highest DSA bead had a high sensitivity (85.7%) and that the sum of all DSA beads MFI > 11,000 had a high specificity (92.3%) for AMR prediction. Anti-thymocyte globulin versus basiliximab induction was more frequent in DSA + AMR − (65.4%) versus DSA + AMR + (34.6%) patients (P = 0.072). Five-year censored graft survival was lower in DSA + than in DSA − patients (respectively, 84.8% versus 94.9%, P = 0.006), although survival was only reduced in DSA + AMR + (68.8%) versus DSA + AMR − (96.0%) patients (P = 0.038). Conclusions Preformed DSA is associated with kidney graft loss, in relation with AMR occurrence. DSA strength may be used to improve immunological risk stratification of sensitized patients and their clinical management.
- Published
- 2015
158. Plenty of land, land of plenty: the agrarian output of Portugal (1311-20)
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António Castro Henriques and Repositório da Universidade de Lisboa
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History ,Internal migration ,Economics, Econometrics and Finance (miscellaneous) ,Subsistence agriculture ,Economic History, Agriculture, Living Standards, Frontier Economy ,Agriculture ,Standard of living ,jel:N53 ,Frontier ,Agrarian society ,Economy ,Agrarian output ,Development economics ,História de Portugal - séc. 14 ,Per capita ,Marginal product ,Economics ,Agrarian system - Abstract
This article presents a benchmark for Portuguese agrarian output for the 1311–20 decade. This benchmark is built from the supply side using the value of church tithes combined with contemporary parish accounts. Two main findings emerge: first, per capita agrarian output was similar in the recently conquered South and the North, hinting that internal migration after the Reconquista led to the equalization of marginal product across the country; second, that Portuguese real per capita agrarian output was above subsistence and higher than that of contemporary England and Wales. This result, which is robust to the assumptions used, confirms that by 1320 Portugal was a “frontier economy” with a high land/labor ratio and a high per capita output. This seems to reinforce the Malthusian theory that the amount of land per person was key in determining living standards. The article discusses the implication of these results for the inequality among nations.
- Published
- 2015
159. HLA class II eplet mismatch load improves prediction of dnDSA development after living donor kidney transplantation.
- Author
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Tafulo, Sandra, Malheiro, Jorge, Santos, Sofia, Dias, Leonídio, Almeida, Manuela, Martins, La Salete, Pedroso, Sofia, Mendes, Cecília, Lobato, Luísa, and Castro‐Henriques, António
- Subjects
KIDNEY transplantation ,MULTIVARIATE analysis ,FORECASTING ,IMMUNOGLOBULINS ,IMMUNE response - Abstract
HLA donor‐specific antibodies developed de novo after transplant remain a major cause of chronic allograft dysfunction. Our study main purpose was to determine whether HLA MM, assessed traditionally and by HLA total and AbVer eplet mismatch load (EptMM and EpvMM) assessed with HLAMatchMaker, had impact on dnDSA development after living donor kidney transplantation (LDKT). We retrospectively analysed a cohort of 96 LDKT between 2008 and 2017 performed in Hospital Santo António. Seven patients developed dnDSA‐II and EpvMM and EptMM were greater in dnDSA‐II group compared to the no dnDSA‐II (18.0 ± 8.7 versus 9.9 ± 7.9, p =.041 and 41.3 ± 18.9 versus 23.1 ± 16.7, p =.018), which is not observed for AgMM (2.29 versus 1.56; p =.09). In a multivariate analysis, we found that preformed DSA (HR = 7.983; p =.023), living unrelated donors (HR = 8.052; p =.024) and retransplantation (HR = 14.393; p =.009) were predictors for dnDSA‐II (AUC = 0.801; 0.622–0.981). HLA‐II EpvMM (HR = 1.105; p =.028; AUC = 0.856) showed to be a superior predictor of dnDSA‐II, when compared to AgMM (HR = 1.740; p =.113; AUC = 0.783), when adjusted for these clinical variables. Graft survival was significantly lower within dnDSA‐II patient group (36% versus 88%, p <.001). HLA molecular mismatch analysis is extremely important to minimize risk for HLA‐II dnDSA development improving outcome and increasing chance of retransplant lowering allosensitization. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
160. Effect of Surface and Heat Treatments on the Biaxial Flexural Strength and Phase Transformation of a Y-TZP Ceramic.
- Author
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Garcia Fonseca, Renata, de Oliveira Abi-Rached, Filipe, Correia Pereira da Silva, Filipe Samuel, Pacheco de Castro Henriques, Bruno Alexandre, and Pereira Pinelli, Ligia Antunes
- Subjects
FLEXURAL strength ,DENTAL ceramics ,PHASE transitions ,DENTAL veneers ,DENTAL materials - Abstract
Purpose: To evaluate the effect of grinding and airborne-particle abrasion on the biaxial flexural strength (BFS) and phase transformation of a Y-TZP ceramic, and examine whether sintering the veneering porcelain renders the previous heat treatment recommended by the manufacturer unnecessary. Materials and Methods: Lava zirconia specimens (N = 108) were obtained with the following dimensions: 14.0 mm diameter x 1.3 mm thickness (n = 36) and 14.0 mm x 1.6 mm (n = 72). The thicker specimens were ground with diamond burs under irrigation and received (heat-treated groups) or not (non-heat-treated groups) a heat treatment (1000ºC for 30 min) prior to the four firing cycles applied to simulate the sintering of the veneering porcelain. All specimens were air abraded as follows (n = 12): 1) 30-μm silica-modified Al
2 O3 particles (Rocatec Soft); 2) 110-μm silica-modified Al2 O3 particles (Rocatec Plus); and 3) 120-μm Al2 O3 particles, followed by Rocatec Plus. Three specimens of each group were analyzed by x-ray diffraction (XRD) to assess the monoclinic phase content (%). The BFS test was performed in a mechanical testing machine (Instron 8874). Data (MPa) were analyzed by two-way ANOVA (grinding x airborne-particle abrasion and heat treatment x airborne-particle abrasion) and Tukey's post-hoc test (α = 0.05). The strength reliability was analyzed using the Weibull distribution. Results: Grinding significantly decreased the BFS of the non-heat-treated groups (p < 0.01). Within the ground groups, the previous heat treatment did not influence the BFS (p > 0.05). Air abrasion only influenced the BFS of the ground/heat-treated groups (p < 0.01). For the non-heat-treated groups, the grinding did not decrease the Weibull modulus (m), but it did decrease the characteristic strength (σ0 ). For Rocatec Soft and 120-μm Al2 O3 particles + Rocatec Plus, the heat-treated groups presented lower m and higher σ0 than the ground/non-heat-treated groups. The independent variables did not seem to influence phase transformation. Air-abraded surfaces presented higher monoclinic zirconia content than the as-sintered and ground surfaces, which exhibited similar content. Conclusion: Even under irrigation, grinding compromised the Y-TZP ceramic strength. The sintering of the veneering porcelain rendered the previous heat treatment recommended by the manufacturer unnecessary. Airborne-particle abrasion influenced the strength of heat-treated zirconia. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
161. Transplantation - clinical II
- Author
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Handan Ozdemir, Himanshu V Patel, Tingli Wang, Izumi Yamamoto, Anna Perri, Eva Svobodova, Alberto Mella, Alexander Kildushevsky, Ole Øyen, Nicolas Congy-Jolivet, Sergio Luis-Lima, Yuangao Zou, Hideki Fuji, Tolga Yildirim, Norihiko Goto, Marian Klinger, Leonídio Dias, Won Seok Yang, Lanlan Wang, Tatjana Cvetkovic, Barbara Assenzio, Filiz Bakar, Samantha Mantovani, Halil Yazici, Vijay Thanaraj, Priyadarshini S Shah, Solbjørg Sagedal, Francesca Sidoti, Anupma Kaul, Giordano Zampi, Dharmendra Bhadauria, Moncef Mokni, Tatjana Jevtovic Stoimenov, Tine Thurison, Alessia Di Nauta, Christos S. Katsouras, Franca Sinesi, Denisa Mendonça, Jude Yagan, Atsushi Miki, Giorgos Spanos, F. Zalamea Jarrin, Maria Cristina Di Vico, Francesca Greco, Marco Ballestri, Veena R Shah, Takashi Yokoo, António Castro Henriques, Pranjal R Modi, Vito Fanelli, Andrey Vatazin, Jiri Fronek, Siren Sezer, Anna Teresa Mazzeo, Takayuki Yamamoto, Karen Stopper, Jerzy Chudek, Antonij Slavcev, Deepak Shankar Ray, Takaaki Kimura, Claudio Musetti, Christina Dörje, Lidija Orlić, Osman Ilhan, Rahmi Yilmaz, Francesca Damiano, Mehmet Gokhan Caglayan, Marcel Naik, Ken Kitamura, Maarten B. Rookmaaker, Arjan D. van Zuilen, Pablo Raffaele, Trond Jenssen, Yosu Luque, Masato Fujisawa, Katerina K. Naka, Giuseppe Paolo Segoloni, Ioannis Gkirdis, Leonardo Caroti, Maarten Naesens, Klemens Budde, Rossana Cavallo, Nanna von der Lippe, Ilaria Mastromauro, A. Azzebi, Rigas Kalaitzidis, Fredrik B. Brekke, António Cabrita, Sławomir Zmonarski, Flavio Vincenti, Alessandro De Vincenzi, Hela Ghezaiel, Vasilis Koutlas, Elena Cremaschi, Dorota Kamińska, Mark A. J. Devonald, Kostas C. Siamopoulos, Mahmut Altindal, Mehtap Ekmen Uyar, Dobrin Svinarov, Abdulrahman Housawi, Sanjin Rački, Wissal Sahtout, Ramazan Cetinkaya, Emre Tutal, Luísa Lobato, Mehmet Sukru Sever, Umberto Maggiore, Momir Mikov, Dorry L. Segev, Inés Beired Val, Stefania Bussolino, Fernando Gil Catalinas, Steffen Thiel, Anna Kotsia, Olesja Rissling, Halil Ermis, Borelli K. Zlatkov, Adam Varga, Efrat Harel, Eva Pokorna, P. Chudoba, Saliha Uyanık, Kostas Pappas, Maria Vittoria Mauro, Viktorija Dragojevic-Simic, Alexey Zulkarnaev, Vural Taner Yilmaz, Mikiko Yoshikawa, Luciana Mascia, Aureliusz Kolonko, Yasunaru Sakuma, Manoj R Gumber, Jens Bollerslev, Maria Boratyńska, Kathy Denesyk, Lionel Rostaing, Fabrizio Fop, Carlo Massimetti, Tak Mao Chan, Jamal Rizvi, Predrag Vlahovic, Anna Maria Degli Antoni, Yasuo Takeuchi, Bård Waldum, Pieter Evenepoel, Dai Kohguchi, Aurelio Rodríguez-Hernández, Marcin Protasiewicz, Yudo Tannno, Samira Ben Amor, Sofia Pedroso, Rusudana Kantaria, Nikola Stefanović, Renzo Bonofilgio, Kristin Godang, Hans-H. Neumayer, Aydin Turkmen, Bosiljka Devcic, Oktawia Mazanowska, Tomasz Dawiskiba, Zeynep Bal, Donatella Vizza, J. Portoles Perez, Maggie Ming Yee Mok, Veronika Fedulkina, Josefina Santos, Byung Ha Chung, Altagracia Bello Ovalle, Lampros Lakkas, Jean-Luc Taupin, Anis Belarbia, Anil Chandraker, Andrea Ranghino, Sharmas Vali, Yaeni Kim, Yong-Soo Kim, Dorota Bartoszek, Sakuma Yasunaru, Mirosław Banasik, Malgorzata Kaminska, Cheol Whee Park, Jonathan Visentin, Fulvia Giaretta, Nobuo Tsuboi, Nathan T. James, Tiziana Cena, Tri Q. Nquyen, Giovanni Piotti, Huseyin Kocak, Armando Torres, Milagros Sierra Carpio, Gabriela Pimentel Guzmán, O. Lafuente Covarrubias, B. Sanchez Sobrino, Yuliya V Smedbraaten, Morten W. Fagerland, Pankaj R Shah, Amin Amro, Maria Granito, Davide Diena, Hargovind L Trivedi, Kenan Keven, Hyuk Y Kwon, Bei Cai, Alena Parikova, Ercan Turkmen, Jean J. Filipov, Marc-Olivier Timsit, Alastair Ferraro, Nicoline M.H. Veldhuijzen, Ibrahim Aliosmanoglu, Koji Nanmoku, R K Sharma, Neven Vavic, Anders Hartmann, Nilgun Aysuna, Geir Mjøen, Barbara Sandor, Gianni Cappelli, Louise Moist, José-Carlos Oliveira, Salima Kejji, Alena Verflova, Haralampos Harisis, Babak J. Orandi, Cristina Izzo, Andras Toth, Ana González-Rinne, Ivana Mikolašević, Mehmet Haberal, Petra Reinke, Akimitsu Kobayashi, Marion Rabant, Agnieszka Sas, Giulia Ligabue, Soumava Gupta, Dmytro Khadzhynov, Soon Bae Kim, Fatih Yılmaz, Gunilla Høyer-Hansen, Fotios Zarzoulas, Semra Bozfakioglu, O. Guliyev, Mehtap Erkmen Uyar, Yasuyuki Nakada, Zeynep Kendi Celebi, Alejandro Jiménez-Sosa, Christophe Legendre, Haralampos Pappas, José Davide, Sandro Feriozzi, Keitaro Yokoyama, Mustafa Arici, Esteban Porrini, Niraj M. Desai, Dany Anglicheau, Enrico Eugenio Minetti, Shunji Narumi, Federica Civiletti, Bahar Gurlek Demirci, Pierre Merville, Pablo Klin, Natalia Negrín-Mena, Roberta Fenoglio, Pratik Das, Marco Quaglia, Abdelatif Achour, Martina Pavletic Persic, Turan Colak, Hallvard Holdaas, Hyun Seon Kim, Charlie Martinez, Nemanja Jacimovic, Sung H Son, Carlo Buzio, Francesco Fontana, Giorgos Tzeltzes, Anders Åsberg, Andrea Kantor, Sébastien Lepreux, Ana Aldea-Perona, Laure-Hélène Noël, Takafumi Yamakawa, Daniela Perugini, Magdalena Szotowska, Ichiro Ohkido, Antonio Gil Paraíso, Aruna V Vanikar, Nurhan Ozdemir Acar, Manuela Guedes de Almeida, Bo Ying Choy, Charles S. Craik, Antoine Bello, Andrzej Wiecek, Bang-Gee Hsu, Massimo Rittà, Cristina Giraldi, Björn Meijers, Gwendaline Guidicelli, Henri Kreis, Chul Woo Yang, Augusto Vaglio, Marit Elizabeth Von Düring, Kouji Nannmoku, Riccardo Magistroni, Yunus Erdem, Katrien De Vusser, Marta Artamendi Larrañaga, Hiroyasu Yamamoto, Luigi Biancone, Giorgos Nakas, Rita Marcela Fortunato, Enma Huarte Loza, Nemanja Rancic, Andrea Airoldi, Katarzyna Koscielska-Kasprzak, Francesca Leone, Kazunari Yoshida, R. Llopez Carratala, Miyeon Kim, Andrea Cossarizza, Gabriele Guglielmetti, G. Tognarelli, Burak Sayin, José Manuel González-Posada, Jin Kong, Bulent Altun, Ingrid Os, Anne Theakstone, Shantanu Bhattacharjya, Piotr Kuczera, Gian Domenico D Fabbri, Lionel Couzi, Yosra Guedri, Nurhan Ozdemir, Cristina Costa, Chung Hee Baek, Emil P. Dimitrov, Ester Gallo, Dirk Kuypers, Hermann Hernandez Vargas, Massimo Gai, Rohit Rungta, Jun-Seok Kim, Piero Stratta, Takashi Yagisawa, Cihat Burak Sayin, Antonio Amoroso, Faisal Rehman, Maria Zanazzi, P. Dominguez Apiñaniz, Teresa Papalia, Franco Brescia, Vesna Lukenda, Ruben Poesen, Gea Imperato, P. Carta, Davide Medica, Alessandra Palmisano, S. Karsten Alvarez, Rozenn Clément, Jelena Katic, F Ersoy, Vladimir Hanzal, Safa Nouira, Manisha Sahay, K. Kalmár-Nagy, Michele Battista, Eun J Whang, Kalman Toth, Andrew A. House, Anna Varberg Reisæter, Hyung Jin Cho, Evangelia Dounousi, Irini Tzalavra, Sabri Ferdaws, Gultekin Suleymanlar, Limei Luo, Ayhan Dinckan, Ilaria Deambrosis, Begum Erdemir, Akinori Nukui, Thomas Schachtner, Karsten Midtvedt, Cecilia Dall Anesse, Ewelina Sikora-Grabka, Domingo Marrero, Ming-Che Lee, Vivek B Kute, Lourdes Pérez-Tamajón, Ana Coloma Lopez, Maria Messina, Ozgur Akin Oto, Lorraine Kwan, Robert A. Montgomery, Aris Bechlioulis, Olga Balafa, Isabel Fonseca, Aida Larti, Magdalena Krajewska, Akira Kurosawa, Toshihisa Iwabuchi, Janka Slatinska, Teppei Ohyama, Agnieszka Hałoń, Daisuke Ishii, Dag Olav Dahle, Su-Kil Park, Soumaya Ben Abdelkrim, Won Y Choi, Fatma Nurhan Ozdemir Acar, Sanda Mrabet, Lorenzo Di Maria, Saliha Yildirim, Oliver Staeck, Aleksandra Kovacevic, Elisa Buti, Yasar Caliskan, Lampros K. Michalis, Makoto Tsujita, Paweł Madej, Michalis Mitsis, Eduardo Salido, Ondrej Viklicky, Kiranmai Ismal, Yoshihiko Watarai, Dimitris Evangelou, Hege Pihlstrøm, Dorsaf Zellama, Chul Soo Yoon, Radmila Veličković Radovanović, Thomas Bachelet, Duck Jong Han, Paolo Gigliotti, Shinichi Nishi, Danilo Lofaro, Nassim Kamar, Fabian Halleck, Charlotte Ng, Erik H. Strøm, Aki Mafune, Sara De Biasi, Selami Kocak Toprak, António Castro-Henriques, Fabiola Pagani, Alaattin Yildiz, Marcin Adamczak, Pablo Bridoux, Marina Colic, Anara Amanova, Kyeong Woo Nho, Anna V. Reisæter, Bum Soon Choi, Hugo Sanabria, Enrique Ramalle Gómara, Ayse Serra Artan, Walther H. Boer, Takahisa Hiramitsu, Narayan Prasad, Albane Sartorius, Juan De Francesco, Daniele Cagna, Jorge Malheiro, Himmet Bora Uslu, Alun Williams, Vincenzo Cantaluppi, Yunying Shi, La Salete Martins, Pål-Dag Line, Péter Szakály, and Takaaki Kobayashi
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Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,Medicine ,business ,Surgery - Published
- 2012
162. A Conquista de Tavira aos Mouros: uma reconstituição crítica.
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CASTRO HENRIQUES, ANTONIO
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PORTUGUESE Americans ,CHRISTIANS ,SOCIETIES - Abstract
Copyright of Revista de Historía da Sociedade e da Cultura is the property of Revista de Historia da Sociedade e da Cultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
163. Incorporating information technology in a network condition
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Gabriela Celani, Olfa Kanoun, and Gonçalo Castro Henriques
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Multimedia ,Computer science ,business.industry ,Information technology ,business ,computer.software_genre ,computer - Published
- 2017
164. Franz Rosenzweig e o Deus reconhecido
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Mendo Castro Henriques
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Philosophy - Published
- 2017
165. WebProcessPAIR: recommendation system for software process improvement
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Pedro Castro Henriques, Luis Amaro, Mushtaq Raza, and João Pascoal Faria
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Engineering ,Root (linguistics) ,business.industry ,020207 software engineering ,02 engineering and technology ,Recommender system ,Crowdsourcing ,Data science ,Software development process ,Software ,Work (electrical) ,020204 information systems ,Personal software process ,0202 electrical engineering, electronic engineering, information engineering ,business ,Software engineering ,Performance model - Abstract
ProcessPAIR is a novel tool for helping software developers analyzing their personal performance. Based on a performance model calibrated from the anonymized performance data of many developers and the performance data submitted by an individual developer, it automatically identifies and ranks potential performance problems and their root causes for that developer. In this work we present WebProcessPAIR, which extends ProcessPAIR with the ability to recommend improvement actions to address the root causes identified, based on a crowdsourcing approach. A case study illustrates WebProcessPAIR usage.
- Published
- 2017
166. A economia circular na indústria portuguesa de pasta, papel e cartão
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Fraga, Manuel António Castro Henriques de Castro, Remígio, Helena, and Duarte, Susana
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Engenharia e Tecnologia::Engenharia Mecânica [Domínio/Área Científica] - Abstract
O elevado desenvolvimento industrial, os novos hábitos de consumo e o crescimento populacional tem levado a uma discussão nos vários setores da sociedade acerca da escassez de recursos, das emissões poluentes, e da produção de resíduos. Desta forma, e em contraposição com o modelo económico linear, no qual os produtos após produzidos e consumidos são eliminados, emerge um novo modelo de negócio: “A Economia Circular”. Este é um modelo baseado na reutilização, recuperação, reciclagem e reparação durante o ciclo de conceção e utilização de um produto. Este trabalho pretende fazer um estudo da economia circular na indústria de pasta, papel e cartão. Este foi o setor escolhido porque para além de representar cerca de 8% da produção industrial nacional, tem feito esforços significativos para promover o desenvolvimento ambientalmente sustentável. Assim a dissertação pretende dar a conhecer o ponto de situação do setor pasta, papel e cartão no âmbito da economia circular, fazendo uma comparação ibérica nos anos compreendidos entre 2011 e 2015 através do desenvolvimento de um índice comparativo baseado nos resultados de alguns indicadores ambientais. Também é feito um levantamento das atuais barreiras existentes, bem como a sua respetiva relevância na implementação plena da economia circular através da utilização do método Delphi. Segundo o estudo realizado o setor pasta, papel e cartão em Portugal apresenta um valor de cerca de 26% superior na implementação da economia circular face ao registado no setor em Espanha em 2015, com a peculiaridade que esta diferença tem vindo a diminuir nos últimos cinco anos. Quanto aos resultados do estudo relativo às atuais barreiras na implementação da economia circular no setor pasta, papel e cartão em Portugal, o estudo aponta que, entre outras, as três mais relevantes são a falta de regulamentação de flexibilização e promoção do intercâmbio de subprodutos, a demora no processo de classificação de substâncias como subprodutos e a perceção de que o produto final proveniente da utilização de subprodutos é de qualidade inferior quando comparado com um produto que use matéria prima virgem.
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- 2017
167. Role of de novo donor-specific anti-HLA antibodies in kidney graft failure: A case-control study
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Leonídeo Dias, Idalina Beirão, Ana Castro, Sandra Tafulo, Isabel Fonseca, António Castro-Henriques, António Cabrita, Jorge Malheiro, and La Salete Martins
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Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Biopsy ,Immunology ,030230 surgery ,Kidney ,Gastroenterology ,Antibodies ,03 medical and health sciences ,0302 clinical medicine ,HLA Antigens ,Risk Factors ,Internal medicine ,Genetics ,medicine ,Immunology and Allergy ,Humans ,Kidney transplantation ,Dialysis ,Proteinuria ,medicine.diagnostic_test ,business.industry ,Proportional hazards model ,Hazard ratio ,Graft Survival ,Case-control study ,Odds ratio ,medicine.disease ,Kidney Transplantation ,Tissue Donors ,surgical procedures, operative ,Logistic Models ,Treatment Outcome ,Case-Control Studies ,Multivariate Analysis ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,business - Abstract
The role of de novo donor-specific anti-human leukocyte antigen (anti-HLA) antibodies (dnDSA) within the pathways leading to graft failure remains not fully understood. We investigated 56 patients who were transplanted between 2002 and 2014 with kidney graft failure (cases), for a possible association of development of dnDSA with graft failure. The 56 patients with failed transplants were matched with 56 patients with a functioning graft at present for the variables deceased or living donor, transplant number, transplant year, recipient age and gender, donor age and gender, dialysis vintage time, transplant induction therapy. All patients had at least one serum collected 1 year before failure (in cases) or end of follow-up (in controls). Cases and controls were very well-matched in several baseline characteristics. Post-transplant anti-HLA antibodies were found in 84% of cases and only 36% of controls (P < .001), with 54% of cases and 16% of controls (P < .001) having dnDSA at time of detection. Chronic active antibody-mediated rejection was significantly more common (P < .001) in patients with dnDSA (61% vs 12%), in 53 (47%) patients that had at least one graft biopsy performed during follow-up. dnDSA was a significant risk factor (odds ratio [OR] = 6.06; P = .003) for graft failure in a multivariable conditional logistic regression model. dnDSA as a time-dependent variable, was also an independent predictor [hazard ratio (HR) = 2.46; P = .002] of graft failure in a multivariable Cox regression analysis. In both statistical approaches, only dnDSA-II (OR = 11.90; P = .006) (HR = 2.30; P = .014) was significantly associated with graft failure. Post-transplant dnDSA was clearly associated with graft loss, particularly if against HLA class II antigens. dnDSA detection should be a tool for post-transplant monitoring of kidney graft recipients, allowing for the identification of those with a higher risk of graft failure.
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- 2017
168. Impact on mid-term kidney graft outcomes of pretransplant anti-HLA antibodies detected by solid-phase assays: Do donor-specific antibodies tell the whole story?
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António Cabrita, La Salete Martins, Idalina Beirão, Leonídio Dias, Isabel Fonseca, António Castro-Henriques, Jorge Malheiro, and Sandra Tafulo
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Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Immunology ,030232 urology & nephrology ,Human leukocyte antigen ,030230 surgery ,Gastroenterology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,HLA Antigens ,Isoantibodies ,Internal medicine ,Immunology and Allergy ,Medicine ,Humans ,Transplantation, Homologous ,Hla antibodies ,Kidney transplantation ,Immunosorbent Techniques ,Retrospective Studies ,Kidney ,biology ,business.industry ,Incidence (epidemiology) ,Donor specific antibodies ,Histocompatibility Testing ,Graft Survival ,General Medicine ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Microspheres ,body regions ,medicine.anatomical_structure ,Treatment Outcome ,Immunoglobulin G ,Cohort ,biology.protein ,Female ,Antibody ,business - Abstract
The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant sera by solid-phase assays. NDSA or DSA were detected in 100 (13.8%) and 47 (6.5%) recipients respectively, while 577 (79.7%) were non-allosensitized (NaS). Incidence of antibody-mediated rejection at 1-year was 0.7%, 4.0% and 25.5% in NaS, NDSA and DSA patients, respectively (NaS vs. NDSA P=0.004; NaS vs. DSA P0.001; NDSA vs. DSA P0.001). Graft survival was lowest in DSA (78.7%), followed by NDSA (88.0%) and NaS (93.8%) recipients (NaS vs. NDSA P=0.015; NaS vs. DSA P0.001; NDSA vs. DSA P=0.378). Multivariable competing risk analysis confirmed both NDSA (sHR=2.19; P=0.025) and DSA (sHR=2.87; P=0.012) as significant predictors of graft failure. The negative effect of NDSA and DSA on graft survival was significant in patients receiving no induction (P=0.019) or an anti-IL-2 receptor antibody (P0.001), but not in those receiving anti-thymocyte globulin (P=0.852). The recognition of the immunological risk associated with preformed DSA but also NDSA have important implications in patients' risk stratification, and may impact clinical decisions at transplant.
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- 2017
169. Scaling Up Nutrition in Guinea-Bissau
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Jakub Kakietek, Edson Araujo, Fanceni Henriques Balde, Jonathan Kweku Akuoku, Julia Dayton Eberwein, António Castro Henriques, Meera Shekar, Linda Brooke Schultz, Michelle Ashwin Mehta, and Ivone Menezes Moreira
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Marginal cost ,Economic growth ,education.field_of_study ,Cost–benefit analysis ,Public economics ,Behavior change ,Population ,Psychological intervention ,Internal rate of return ,Context (language use) ,Economics ,education ,health care economics and organizations ,Disease burden - Abstract
This paper builds on global experience and Guinea-Bissau's specific context to identify an effective nutrition approach along with costs and benefits of key nutrition interventions. It is intended to help guide the selection of the most cost-effective interventions as well as strategies for scaling these up. We estimate that the costs and benefits of implementing 10 nutrition-specific interventions in all regions of Guinea-Bissau would require a public investment of USD 17 million over five years (with about USD 3 million needed to maintain the current coverage of the interventions and USD 14 million needed to expand the coverage to reach 90 percent of the population). The two key conclusions of this paper are, first, that investing in nutrition in Guinea-Bissau is cost-effective based on international standards and, second, that investments in nutrition can generate very substantial health and economic benefits, with one dollar spent on nutrition interventions resulting in about 10 dollars of returns over the productive lives of children covered by high-impact nutrition interventions. Economic productivity could potentially increase by USD 120 million (discounted at 3 percent) over the productive lives of the beneficiaries, with an impressive internal rate of return of 9 percent annually. Theses findings point to a powerful set of nutrition-specific interventions that represent a high cost-effective approach to reducing child malnutrition and stunting in Guinea-Bissau.
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- 2017
170. Scaling Up Nutrition in Guinea-Bissau : What Will it Cost?
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Kakietek, Jakub, Castro Henriques, Antonio, Schultz, Linda, Mehta, Michelle, Dayton Eberwein, Julia, Akuoku, Jonathan Kweku, Menezes Moreira, Ivone, Balde, Fanceni Henriques, Araujo, Edson C., and Shekar, Meera
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NUTRITION ,NUTRITION FINANCING ,COST-BENEFIT ANALYSIS ,health care economics and organizations - Abstract
This paper builds on global experience and Guinea-Bissau's specific context to identify an effective nutrition approach along with costs and benefits of key nutrition interventions. It is intended to help guide the selection of the most cost-effective interventions as well as strategies for scaling these up. We estimate that the costs and benefits of implementing 10 nutrition-specific interventions in all regions of Guinea-Bissau would require a public investment of USD 17 million over five years (with about USD 3 million needed to maintain the current coverage of the interventions and USD 14 million needed to expand the coverage to reach 90 percent of the population). The two key conclusions of this paper are, first, that investing in nutrition in Guinea-Bissau is cost-effective based on international standards and, second, that investments in nutrition can generate very substantial health and economic benefits, with one dollar spent on nutrition interventions resulting in about 10 dollars of returns over the productive lives of children covered by high-impact nutrition interventions. Economic productivity could potentially increase by USD 120 million (discounted at 3 percent) over the productive lives of the beneficiaries, with an impressive internal rate of return of 9 percent annually. Theses findings point to a powerful set of nutrition-specific interventions that represent a high cost-effective approach to reducing child malnutrition and stunting in Guinea-Bissau.
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- 2017
171. Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody
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Santos, S., Castro, A., Campos, A., Pedroso, S., Dias, L., and Castro-Henriques, A.
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Donor-specific antibodies (DSA) ,Antibody-mediated rejection (AMR) ,Anti-HLA-Cw antibodies - Abstract
We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies. info:eu-repo/semantics/publishedVersion
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- 2017
172. Predictive Factors of Graft-Censored Failure in Pediatric Kidney Transplantation
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António Castro Henriques, T. Tavares, Jorge Malheiro, Leonídeo Dias, Ana Rocha, Maria do Sameiro Faria, Liliana Rocha, Pedro Vieira de Azevedo, and Conceição Mota
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Graft Rejection ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Human leukocyte antigen ,Serology ,Young Adult ,Internal medicine ,medicine ,Humans ,Registries ,Child ,Kidney transplantation ,Dialysis ,Acute tubular necrosis ,Transplantation ,Univariate analysis ,business.industry ,Age Factors ,Odds ratio ,medicine.disease ,Kidney Transplantation ,Tissue Donors ,Surgery ,surgical procedures, operative ,Child, Preschool ,Multivariate Analysis ,Female ,business - Abstract
Kidney transplantation in children has shown steady improvement in graft survival outcome over the last decades. Using data obtained from the transplantation registry of our center between 1984 and 2012, we assessed the independent determinants of graft failure using the Cox proportional hazards regression. Altogether, 128 recipients younger than 18 years of age at the time of kidney transplantation and who had >3 months graft survival were studied. During 9.95 years of medium follow-up, 27 censored graft failures occurred. Censored graft survival rates at 5, 10, 15, and 20 years post-transplantation were 93%, 82%, 70%, and 63%, respectively. Studied factors included recipient and donor age, recipient gender, dialysis vintage, donor/recipient cytomegalovirus (CMV) serology, panel-reactive antibody percentage, human leukocyte antigen mismatching, previous transplantation number, donor type (deceased vs living donation), cold ischemia time, induction therapy with antithymocyte globulin, occurrence of acute tubular necrosis, and development of acute rejection. Using univariate analysis, the significant predictors for graft-censored failure were adult donor (P < .001), recipient age (P = .035), human leukocyte antigen mismatching (P = .025), antithymocyte globulin induction (P = .03), and development of acute rejection (P < .001). Two factors independently predicted graft-censored failure in multivariate analysis. The odds ratios for graft failure in patients with acute rejection and in children who received an organ of an adult were 3.744 and 4.962, respectively. Pediatric recipients should receive the first priority for allografts from pediatric donors and acute rejection should be meticulously prevented.
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- 2014
173. Kidney Transplantation Across a Positive Crossmatch: A Single-Center Experience
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Sandra Tafulo, S. Pedroso, R. Costa, Jorge Malheiro, António Cabrita, Cledir Santos, Leonídeo Dias, Manuela Guedes de Almeida, La Salete Martins, and António Castro Henriques
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Adult ,Graft Rejection ,Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Urology ,Single Center ,Antibodies ,Antibodies, Monoclonal, Murine-Derived ,chemistry.chemical_compound ,HLA Antigens ,medicine ,Humans ,Immunologic Factors ,Kidney transplantation ,Retrospective Studies ,Transplantation ,Kidney ,Creatinine ,business.industry ,Histocompatibility Testing ,Panel reactive antibody ,Immunoglobulins, Intravenous ,Plasmapheresis ,Flow Cytometry ,medicine.disease ,Kidney Transplantation ,Surgery ,medicine.anatomical_structure ,chemistry ,Desensitization, Immunologic ,Female ,Rituximab ,business ,medicine.drug - Abstract
Background Kidney transplantation is the treatment of choice for end-stage renal disease, with improved mortality and quality of life compared with dialysis. Desensitization protocols have allowed kidney transplantation of highly sensitized patients, who have a lower probability to receive a matching kidney from a deceased or living donor. The aim of this work was to analyze the post-transplantation period of highly HLA-sensitized patients with positive flow cytometry crossmatch against donor cells. Methods Following an observational, retrospective design, we investigated 16 highly sensitized patients who underwent kidney or kidney-pancreas transplantation, assessing the impact of desensitization protocols and investigating treatment-related complications, graft function, antibody-mediated rejection (AMR) rate, and graft and patient survivals. Results We studied 16 patients with positive flow cytometry crossmatch, who were divided into 2 groups based on whether they were submitted to a desensitization protocol or not. Patients who were desensitized underwent transplantation in later years, had higher immunologic risk (panel reactive antibody peak 62% vs 33%; P = .038), higher percentage of 2nd kidney transplant (75% vs 25%; P = .066), and higher percentage of donor-specific anti-HLA antibodies identified (P = .028). A majority of patients were desensitized with high-dose intravenous immunoglobulin and plasmapheresis, and 5 patients received rituximab. Acute AMR rate was of 38%, and rituximab was associated with fewer episodes of AMR. Only 1 patient had graft failure, due to chronic humoral rejection, and the remaining maintained good graft function (mean serum creatinine value of 1.33 mg/dL). No patient died and few complications related to immunossupression were observed. Conclusions Desensitization protocols were safe and allowed kidney transplantation in highly sensitized patients that probably would never undergo transplantation and gave the opportunity of living-donor transplant to patients with anti-HLA antibodies against the donor.
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- 2014
174. TRANSPLANTATION CLINICAL 1
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T. Schachtner, P. Reinke, C. Dorje, G. Mjoen, K. Midtvedt, E. H. Strom, O. Oyen, T. Jenssen, A. V. Reisaeter, Y. V. Smedbraaten, S. Sagedal, M. W. Fagerland, A. Hartmann, S. Thiel, A. Zulkarnaev, A. Vatazin, F. Vincenti, E. Harel, A. Kantor, T. Thurison, G. Hoyer-Hansen, C. Craik, V. B. Kute, P. S. Shah, A. V. Vanikar, P. R. Modi, P. R. Shah, M. R. Gumber, H. V. Patel, D. P. Engineer, V. R. Shah, J. Rizvi, H. L. Trivedi, J. Malheiro, L. Dias, L. S. Martins, I. Fonseca, S. Pedroso, M. Almeida, A. Castro-Henriques, A. Cabrita, C. Costa, M. Ritta, F. Sinesi, F. Sidoti, S. Mantovani, A. Di Nauta, M. Messina, R. Cavallo, A. Verflova, E. Svobodova, J. Slatinska, A. Slavcev, E. Pokorna, O. Viklicky, J. Yagan, A. Chandraker, D. Diena, G. Tognarelli, A. Ranghino, S. Bussolino, F. Fop, G. P. Segoloni, L. Biancone, F. Leone, M. V. Mauro, P. Gigliotti, D. Lofaro, F. Greco, D. Perugini, T. Papalia, A. Perri, D. Vizza, C. Giraldi, R. Bonofilgio, S. Luis-Lima, D. Marrero, A. Gonzalez-Rinne, A. Torres, E. Salido, A. Jimenez-Sosa, A. Aldea-Perona, J. M. Gonzalez-Posada, L. Perez-Tamajon, A. Rodriguez-Hernandez, N. Negrin-Mena, E. Porrini, H. Pihlstrom, D. O. Dahle, H. Holdaas, N. Von Der Lippe, B. Waldum, F. Brekke, A. Amro, I. Os, P. Klin, H. Sanabria, P. Bridoux, J. De Francesco, R. M. Fortunato, P. Raffaele, J. Kong, S. H. Son, H. Y. Kwon, E. J. Whang, W. Y. Choi, C. S. Yoon, V. Thanaraj, A. Theakstone, K. Stopper, A. Ferraro, S. Bhattacharjya, M. Devonald, A. Williams, A. Mella, E. Gallo, M. C. Di Vico, F. Pagani, M. Gai, H. J. Cho, K. W. Nho, S.-K. Park, S. B. Kim, K. Yoshida, D. Ishii, T. Ohyama, D. Kohguchi, Y. Takeuchi, A. Varga, B. Sandor, K. Kalmar-Nagy, A. Toth, K. Toth, P. Szakaly, A. Kildushevsky, V. Fedulkina, R. Kantaria, O. Staeck, F. Halleck, O. Rissling, M. Naik, H.-H. Neumayer, K. Budde, D. Khadzhynov, D. Bhadauria, A. Kaul, N. Prasad, R. K. Sharma, S. Sezer, Z. Bal, M. Erkmen Uyar, O. Guliyev, B. Erdemir, T. Colak, N. Ozdemir, M. Haberal, Y. Caliskan, H. Yazici, A. S. Artan, O. A. Oto, N. Aysuna, S. Bozfakioglu, A. Turkmen, A. Yildiz, M. S. Sever, T. Yagisawa, A. Nukui, T. Kimura, K. Nannmoku, A. Kurosawa, Y. Sakuma, A. Miki, F. Damiano, G. Ligabue, S. De Biasi, M. Granito, A. Cossarizza, G. Cappelli, A. C. Henriques, J. Davide, M. E. Von During, T. G. Jenssen, J. Bollerslev, K. Godang, A. Asberg, T. Bachelet, C. Martinez, A. Bello, S. Kejji, L. Couzi, G. Guidicelli, S. Lepreux, J. Visentin, N. Congy-Jolivet, L. Rostaing, J.-L. Taupin, N. Kamar, P. Merville, H. Ozdemir, S. Yildirim, E. Tutal, B. Sayin, N. Ozdemir Acar, M. Banasik, M. Boratynska, K. Koscielska-Kasprzak, D. Kaminska, D. Bartoszek, O. Mazanowska, M. Krajewska, S. Zmonarski, P. Chudoba, T. Dawiskiba, M. Protasiewicz, A. Halon, A. Sas, M. Kaminska, M. Klinger, N. Stefanovic, T. Cvetkovic, R. Velickovic - Radovanovic, T. Jevtovic - Stoimenov, P. Vlahovic, R. Rungta, P. Das, D. S. Ray, S. Gupta, A. Kolonko, M. Szotowska, P. Kuczera, J. Chudek, A. Wiecek, E. Sikora-Grabka, M. Adamczak, P. Madej, A. Amanova, Z. Kendi Celebi, F. Bakar, M. G. Caglayan, K. Keven, C. Massimetti, G. Imperato, G. Zampi, A. De Vincenzi, G. D. D. Fabbri, F. Brescia, S. Feriozzi, J. J. Filipov, B. K. Zlatkov, E. P. Dimitrov, D. A. Svinarov, R. Poesen, K. De Vusser, P. Evenepoel, D. Kuypers, M. Naesens, B. Meijers, H. Kocak, V. T. Yilmaz, F. Yilmaz, H. B. Uslu, I. Aliosmanoglu, H. Ermis, A. Dinckan, R. Cetinkaya, F. F. Ersoy, G. Suleymanlar, J.-C. Oliveira, J. Santos, L. Lobato, D. Mendonca, Y. Watarai, T. Yamamoto, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, T. Kobayashi, P.-D. Line, A. Housawi, A. House, C. Ng, K. Denesyk, F. Rehman, L. Moist, C. Musetti, M. Battista, C. Izzo, G. Guglielmetti, A. Airoldi, P. Stratta, T. Cena, M. Quaglia, R. Fenoglio, D. Cagna, A. Amoroso, A. Palmisano, A. M. Degli Antoni, A. Vaglio, G. Piotti, E. Cremaschi, C. Buzio, U. Maggiore, M.-C. Lee, B.-G. Hsu, F. Zalamea Jarrin, B. Sanchez Sobrino, O. Lafuente Covarrubias, S. Karsten Alvarez, P. Dominguez Apinaniz, R. Llopez Carratala, J. Portoles Perez, T. Yildirim, R. Yilmaz, E. Turkmen, M. Altindal, M. Arici, B. Altun, Y. Erdem, E. Dounousi, M. Mitsis, K. Naka, H. Pappas, L. Lakkas, H. Harisis, K. Pappas, V. Koutlas, I. Tzalavra, G. Spanos, L. Michalis, K. Siamopoulos, T. Iwabuchi, K. Nanmoku, S. Yasunaru, M. Yoshikawa, K. Kitamura, H. Fuji, M. Fujisawa, S. Nishi, P. Carta, M. Zanazzi, E. Buti, A. Larti, L. Caroti, L. Di Maria, E. E. Minetti, Y. Shi, L. Luo, B. Cai, T. Wang, Y. Zou, L. Wang, Y. Kim, H. S. Kim, B. S. Choi, C. W. Park, C. W. Yang, Y.-S. Kim, B. H. Chung, C. H. Baek, M. Kim, J.-S. Kim, W. S. Yang, D. J. Han, I. Mikolasevic, S. Racki, V. Lukenda, M. P. Persic, M. Colic, B. Devcic, L. Orlic, B. Gurlek Demirci, C. B. Say N, F. N. Ozdemir Acar, S. Vali, K. Ismal, M. Sahay, F. Civiletti, V. Cantaluppi, D. Medica, A. T. Mazzeo, B. Assenzio, I. Mastromauro, I. Deambrosis, F. Giaretta, V. Fanelli, L. Mascia, I. Gkirdis, A. Bechlioulis, D. Evangelou, F. Zarzoulas, A. Kotsia, O. Balafa, G. Tzeltzes, G. Nakas, R. Kalaitzidis, C. Katsouras, S. Uyanik, S. K. Toprak, O. Ilhan, M. Ekmen Uyar, H. Hernandez Vargas, M. Artamendi Larranaga, E. Ramalle Gomara, F. Gil Catalinas, A. Bello Ovalle, G. Pimentel Guzman, A. Coloma Lopez, M. Sierra Carpio, A. Gil Paraiso, C. Dall Anesse, I. Beired Val, E. Huarte Loza, B. Y. Choy, L. Kwan, M. Mok, T. M. Chan, T. Yamakawa, A. Kobayashi, I. Yamamoto, A. Mafune, Y. Nakada, Y. Tannno, N. Tsuboi, H. Yamamoto, K. Yokoyama, I. Ohkido, T. Yokoo, Y. Luque, D. Anglicheau, M. Rabant, R. Clement, H. Kreis, A. Sartorius, L.-H. Noel, M.-O. Timsit, C. Legendre, N. Rancic, N. Vavic, V. Dragojevic-Simic, J. Katic, N. Jacimovic, A. Kovacevic, M. Mikov, N. M. H. Veldhuijzen, M. B. Rookmaaker, A. D. Van Zuilen, T. Q. Nquyen, W. H. Boer, W. Sahtout, H. Ghezaiel, A. Azzebi, S. Ben Abdelkrim, Y. Guedri, S. Mrabet, S. Nouira, S. Ferdaws, S. Amor, A. Belarbia, D. Zellama, M. Mokni, A. Achour, A. Parikova, V. Hanzal, J. Fronek, B. J. Orandi, N. T. James, R. A. Montgomery, N. M. Desai, D. L. Segev, F. Fontana, M. Ballestri, and R. Magistroni
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Transplantation ,Nephrology - Published
- 2014
175. Infections Following Kidney Transplant in Children: A Single-Center Study
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Alexandre Fernandes, Maria do Sameiro Faria, Liliana Rocha, António Castro Henriques, Laura Marques, Conceição Mota, Teresa Costa, and Paula Mena Matos
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medicine.medical_specialty ,business.industry ,Urinary system ,medicine.medical_treatment ,Congenital cytomegalovirus infection ,Immunosuppression ,medicine.disease ,Single Center ,Surgery ,Nephropathy ,Internal medicine ,Etiology ,Medicine ,business ,Meningitis ,Kidney transplantation - Abstract
Introduction: Infections are a major cause of morbidity and mortality in pediatric patients undergoing kidney transplantation (KT). Aim and Methods: To determine the patterns of infectious complications during the first 6 months post transplantation, we report our single center experience with data from pediatric kidney recipients transplanted between 2006 and 2011. Results: Thirty-two children (20 males) were submitted to KT. The most common cause of end-stage renal disease (ESRD) was congenital anomalies of the kidney and urinary tract (CAKUT) accounting for 62%. Over the first 6 months post-transplant period, twenty-eight (87.5%) children developed a total of 77 infections, mainly urinary tract infections (UTI) (64.9%). CAKUT etiology of ESRD and UTI before KT increased the risk to develop more than one episode of UTI [71.4% vs. 14.3% and 81.8% vs. 18.2%, respectively; p < 0.05]. Twenty-three (29.9%) viral infections occurred. Cytomegalovirus (CMV) was the most common opportunistic pathogen, occurred in 11 patients and was more frequently in those with a donor (D)+/recipient (R)- CMV sero-status [74.5% vs. 25.5% (p < 0.05)]. A polyomaviruses (BKV) disease with nephropathy and meningitis was registered. The majority of infectious episodes had mild or moderate severity. No deaths occurred. Conclusion: A significant number of patients presented infectious complications during the first 6 months post transplantation. UTI are the most common type of infection, followed by viral infections, particularly CMV. Recognition, prevention and early treatment of infections are of major importance.
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- 2014
176. The Ola, Consciencia Project
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Mendo Castro Henriques and Nazaret Barros
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Philosophy - Published
- 2014
177. Desafiando a Gravidade: da estática à dinâmica, de objetos a sistemas
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Gonçalo Castro Henriques and Andrés Martín Passaro
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Spacetime ,Computer science ,0211 other engineering and technologies ,02 engineering and technology ,Observer (special relativity) ,Space (commercial competition) ,Object (philosophy) ,law.invention ,Development (topology) ,Human–computer interaction ,law ,021105 building & construction ,Applied research ,Cartesian coordinate system ,Design methods ,021106 design practice & management - Abstract
In the cold space of information objects drift in the void. All is abandoned in junk space or fiercely organized. The difference between an object as a form and formations - or interacting populations of elements in an environment - is still disregarded. In Cartesian space objects are preconceived by an external observer, in static and timeless space. In parametric space Euclidian geometries persist as preconfigured objects. The flux of information between physical and digital realities is still archaic: is done with effort, demanding physical strength and time. There is low interaction between physical and digital realities. Seems like a dystopian reality in a past?future. The theory of relativity asserts that space and time are interdependent, being modified and modifying us. In organic and synthetic biology, form results from the dynamic interaction of elements. This Research argues that form and environment are interdependent in physical and digital dimensions. A two-part applied research method is proposed: preliminary research and further development via workshop. Preliminary research identified the knowledge areas involved, defined problem search space and tested methods and techniques to solve it. The successfully developed design methodology - combining the preliminary research and workshop - can be used to solve future design problems.
- Published
- 2016
178. Impact of Donor-Specific Anti-HLA Antibodies on Chronic-Active Antibody-Mediated Rejection Histological Phenotype and Outcome is Modulated by Non-Adherent behavior of Kidney Graft Recipients
- Author
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Sofia Santos, Jorge Malheiro, La Salete Martins, Leonídio Dias, Sandra Tafulo, and António Castro-Henriques
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Transplantation ,Kidney ,medicine.anatomical_structure ,business.industry ,Chronic Active ,Antibody mediated rejection ,Immunology ,Medicine ,Hla antibodies ,business ,Phenotype - Published
- 2018
179. FP722COMPLEMENT-BINDING DONOR-SPECIFIC ANTIBODIES DETECTED AT DIAGNOSIS OF ANTIBODY-MEDIATED REJECTION ARE ASSOCIATED WITH HIGHER HISTOPATHOLOGICAL HUMORAL ACTIVITY AND WORSE KIDNEY GRAFT SURVIVAL
- Author
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La Salete Martins, Sofia Santos, Sofia Pedroso, Sandra Tafulo, Jorge Malheiro, António Castro-Henriques, Leonídio Dias, and Manuela Guedes de Almeida
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Transplantation ,Kidney ,medicine.anatomical_structure ,Nephrology ,business.industry ,Donor specific antibodies ,Antibody mediated rejection ,Immunology ,medicine ,Graft survival ,business - Published
- 2018
180. Bernard Lonergan e a Probabilidade Emergente.
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CASTRO HENRIQUES, MENDO
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HUMAN behavior ,PROBABILITY theory ,HEURISTIC ,FREE will & determinism ,CONTINUITY ,INDETERMINISM (Philosophy) - Abstract
In Insight, an essay on human understanding, (1957, 1st edition) Lonergan presents a heuristic model of emerging probability in order to define, explain and extract norms from the dynamism common to all nature, including human nature, a dynamism that mirrors the reality of intellection. Continuity between different levels of nature discloses a directed, upward, but indeterminate dynamism of the emerging generalized probability. In addition to the ethical consequences that he elaborates, Lonergan remains in an open hermeneutic framework, beyond being proportionate to discursive reason; he opens the way for a surprising final manifestation of this universal dynamism through what he calls transcendent conjugated forms of generalized probability emerging -- faith, hope and charity -- that are proposed to human freedom. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
181. Theses in Medieval History, 2010-2018: An Overview.
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Castro Henriques, António
- Subjects
MIDDLE Ages ,HISTORIOGRAPHY ,UNIVERSITIES & colleges ,ACADEMIC dissertations - Abstract
Copyright of E-Journal of Portuguese History is the property of Brill Academic Publishers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
182. Pulmonary Embolism: central vs. peripheral - different presentations and different outcomes?
- Author
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De Castro Henriques De Lima, Filipa, primary, China Pereira, Nuno, additional, Ribeiro, Carla, additional, Silva, Eloísa, additional, Vanzeller, Manuela, additional, and Shiang, Teresa, additional
- Published
- 2018
- Full Text
- View/download PDF
183. FP722COMPLEMENT-BINDING DONOR-SPECIFIC ANTIBODIES DETECTED AT DIAGNOSIS OF ANTIBODY-MEDIATED REJECTION ARE ASSOCIATED WITH HIGHER HISTOPATHOLOGICAL HUMORAL ACTIVITY AND WORSE KIDNEY GRAFT SURVIVAL
- Author
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Malheiro, Jorge, primary, Santos, Sofia, additional, Tafulo, Sandra, additional, Dias, Leonídio, additional, Martins, La Salete, additional, Almeida, Manuela, additional, Pedroso, Sofia, additional, and Castro-Henriques, António, additional
- Published
- 2018
- Full Text
- View/download PDF
184. Pregnancy After Kidney Transplantation: Graft, Mother, and Newborn Complications
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J. Braga, Isabel Fonseca, Jorge Malheiro, La Salete Martins, António Castro Henriques, Ana Rocha, and A. Cardoso
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Adult ,medicine.medical_specialty ,Birth weight ,medicine.medical_treatment ,Preeclampsia ,Young Adult ,Pregnancy ,Interquartile range ,medicine ,Humans ,Caesarean section ,Kidney transplantation ,Retrospective Studies ,Gynecology ,Transplantation ,business.industry ,Graft Survival ,Infant, Newborn ,Gestational age ,medicine.disease ,Kidney Transplantation ,Pregnancy Complications ,Gestational diabetes ,Female ,Surgery ,business - Abstract
An important benefit associated with kidney transplantation (KT) in women of childbearing age is increased fertility. We retrospectively evaluated the complications associated with 24 pregnancies among our KT over 28 years. In particular, we examined the evolution of serum creatinine as well as maternal and fetal complications. To assess the impact on graft survival, our control group included women without pregnancy who were matched for age at KT, year of KT, and follow-up time. Most women (79.2%) were primiparous. All were prescribed a calcineurin inhibitor, which in 75% of the cases was cyclosporine. Overall, 45.8% had prior hypertension, only one of whom remained on the previous antihypertensive regimen. The drugs most often used were nifedipine and methyldopa. The median age at time of KT was 24.16 (interquartile range [IQR] 21.33 to 29.72) years and at delivery, 28.39 (IQR 25.59 to 33.88) years. The average interval between KT and delivery was 4.5 ± 2.7 years (range, 1 to 10 years). Maternal complications were anemia (n = 16), graft pyelonephritis (n = 6), preeclampsia (n = 6), de novo proteinuria > 1 g/d (n = 3), or gestational diabetes mellitus (n = 2). There was no acute rejection episode or opportunistic infection. The fetal complications included delayed intrauterine growth (n = 8), preterm deliveries (n = 13), or congenital enzymatic deficit (n = 1). One case was a twin pregnancy. The average gestational age was 35.2 ± 3 weeks, and the mean birth weight 2318.2 ± 597.1 grams. In 16 pregnancies, deliveries were performed by caesarean section. The median serum creatinine at 1 month before conception was 1.20 (IQR 0.97 to 1.37) mg/dL and at 1 year after delivery it had tended to increase to 1 to 20 (IQR 1.03 to 1.50) mg/dL. Death-censored graft survival did not differ from the control group. In conclusion, pregnancy after KT may be associated with serious maternal and fetal complications. We did not observe an increased risk of graft loss.
- Published
- 2013
185. Strategies to control daylight in a responsive skylight system
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José Pinto Duarte, Gonçalo Castro Henriques, and Vítor Leal
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Engineering ,business.industry ,Process (computing) ,Control engineering ,Context (language use) ,Building and Construction ,Skylight ,Control and Systems Engineering ,Daylight ,Software analysis pattern ,Engineering design process ,business ,Heuristics ,Simulation ,Civil and Structural Engineering ,Parametric statistics - Abstract
This research aims to develop a skylight system that responds to both external, environmental conditions and adjustable internal functional demands. The system adapts to different geometries, uses, locations, times and sky conditions. In the design process, the disposition and size of skylights are customized to the context. After construction, the apertures of the skylights control interior conditions. This paper focuses on the dynamic process to control daylight using a case study. The goal is to assure adequate illuminance and low visual contrast. Parametric and environmental software analysis is used to generate and assess solutions. Heuristics strategies are developed to find adequate configurations, given that optimization methods are time and resource consuming. The performance of such configurations is evaluated in specific conditions. An interpolation method is proposed to find configurations adequate to other conditions. A friendly-interface allows selecting the best configuration in real-time using multi-criteria.
- Published
- 2012
186. Determining donor-specific antibody C1q-binding ability improves the prediction of antibody-mediated rejection in human leucocyte antigen-incompatible kidney transplantation
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Leonídio Dias, Isabel Fonseca, La Salete Martins, Idalina Beirão, Jorge Malheiro, António Castro-Henriques, Sandra Tafulo, and António Cabrita
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Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Human leucocyte antigen ,Biopsy ,030232 urology & nephrology ,chemical and pharmacologic phenomena ,030230 surgery ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,HLA Antigens ,Isoantibodies ,Risk Factors ,Internal medicine ,medicine ,Odds Ratio ,Humans ,Risk factor ,Kidney transplantation ,Retrospective Studies ,Transplantation ,Kidney ,biology ,business.industry ,Donor specific antibodies ,Complement C1q ,Graft Survival ,Histocompatibility Antigens Class I ,Histocompatibility Antigens Class II ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Tissue Donors ,body regions ,medicine.anatomical_structure ,Immunoglobulin G ,Antibody mediated rejection ,Immunology ,Multivariate Analysis ,Diagnostic odds ratio ,biology.protein ,Female ,Antibody ,business ,Algorithms - Abstract
Detrimental impact of preformed donor-specific antibodies (DSAs) against human leucocyte antigens on outcomes after kidney transplantation are well documented, however, the value of their capacity to bind complement for predicting antibody-mediated rejection (AMR) and graft survival still needs to be confirmed. We aimed to study DSA characteristics (strength and C1q binding) that might distinguish harmful DSA from clinically irrelevant ones. We retrospectively studied 60 kidney-transplanted patients with preformed DSA detected by single antigen bead (SAB) assays (IgG and C1q kits), from a cohort of 517 kidney graft recipients (124 with detectable anti-HLA antibodies). Patients were divided into DSA strength (MFI < vs. ≥ 15 000) and C1q-binding ability. AMR frequency was high (30%) and it increased with DSA strength (P = 0.002) and C1q+ DSA (P < 0.001). The performance of DSA C1q-binding ability as a predictor of AMR was better than DSA strength (diagnostic odds ratio 16.3 vs. 6.4, respectively). Furthermore, a multivariable logistic regression showed that C1q+ DSA was a risk factor for AMR (OR = 16.80, P = 0.001), while high MFI DSAs were not. Graft survival was lower in high MFI C1q+ DSA in comparison with patients with C1q- high or low MFI DSA (at 6 years, 38%, 83% and 80%, respectively; P = 0.001). Both DSA strength and C1q-binding ability assessment seem valuable for improving pretransplant risk assessment. Since DSA C1q-binding ability was a better predictor of AMR and correlated with graft survival, C1q-SAB may be a particularly useful tool.
- Published
- 2016
187. MP29-20 COMPARISON OF CT-MEASURED SPLIT RENAL VOLUME AND SPLIT RENAL FUNCTION BY DTPA CINTIGRAPHY FOR THE PREDICTION OF 12 MONTHS KIDNEY GRAFT FUNCTION
- Author
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Leonídio Dias, Diogo Carneiro, Manuela Guedes de Almeida, António Castro-Henriques, José Soares, Jorge Malheiro, Jorge Amil Dias, Avelino Fraga, Miguel Ramos, Daniel Oliveira-Reis, and Diogo Gil-Sousa
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Kidney ,medicine.anatomical_structure ,business.industry ,Urology ,Medicine ,Renal function ,business ,Nuclear medicine ,Graft function ,Volume (compression) - Published
- 2016
188. Sensitive Shelters: Poetics of Interaction
- Author
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Andrés Martin Passaro, Goncalo Castro Henriques, and Rodrigo Paraizo
- Published
- 2016
189. Responsive Systems: Foundations and Application - The importance of defining meta-systems and their methods
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Goncalo Castro Henriques
- Published
- 2016
190. Defying Gravity: from statics to dynamics, from objects to systems
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Goncalo Castro Henriques and Passaro, Andres
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- 2016
- Full Text
- View/download PDF
191. Arquitetura algorítmica: Técnicas, processos e fundamentos
- Author
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Goncalo Castro Henriques
- Published
- 2016
- Full Text
- View/download PDF
192. BK virus nephropathy in kidney transplantation - A literature review following a clinical case
- Author
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Barreto, P., Almeida, M., Dias, L., Vieira, P., Pedroso, S., Martins, L., Castro-Henriques, A., and Cabrita, A.
- Subjects
kidney transplant ,BK virus ,Nephritis ,Therapeutic interventions ,Atypical presentation ,Early diagnosis - Abstract
Over the last 15 years, better immunosuppressive drugs have decreased acute rejection rates in kidney transplantation but have also led to an increase in the incidence and impact of BK virus nephropathy. The authors report the case of a 62 -year -old man submitted to a renal transplant of a deceased donor with an immunosuppression regimen free of rabbit anti -thymocyte globulin and tacrolimus, in whom BK nephropathy was diagnosed at seven weeks post -transplant. Intravenous human immunoglobulin (IVIG) was administered after immunosuppression reduction. Instituted treatment was successful. This clinical case highlights the importance of a high index of suspicion for an atypical presentation of BK nephropathy in renal transplant recipients and strengthens the need for other therapeutic interventions beyond the reduction of immunosuppression. It was the starting point for a review of BK virus nephropathy in kidney transplantation with a focus on risk factors, diagnosis and treatment. info:eu-repo/semantics/publishedVersion
- Published
- 2016
193. Pancreas-kidney transplantation: clinical, metabolic and immunological outcomes
- Author
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Martins, L. and Castro-Henriques, A.
- Abstract
Submitted by José Pereira (jro.pereira@gmail.com) on 2016-04-26T14:03:02Z No. of bitstreams: 1 Pancreas.pdf: 245460 bytes, checksum: 1783845f7503318a0ab0218efcd62614 (MD5) Made available in DSpace on 2016-04-26T14:03:02Z (GMT). No. of bitstreams: 1 Pancreas.pdf: 245460 bytes, checksum: 1783845f7503318a0ab0218efcd62614 (MD5) Previous issue date: 2016
- Published
- 2016
194. Transplante reno-pancreático: resultados clínicos, metabólicos e imunológicos
- Author
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Martins, L. and Castro-Henriques, A.
- Published
- 2016
195. Implications for patients waiting for a kidney transplant of using the calculated panel reactive antibody (cPRA)
- Author
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Magriço, R., Malheiro, J., Tafulo, S., Pedroso, S., Almeida, M., Martins, L., Dias, L., Castro-Henriques, A., and Cabrita, A.
- Subjects
Allocation algorithm ,Calculated PRA ,Cytotoxic PRA ,Highly sensitized patients ,Waiting time ,Kidney transplant - Abstract
Introduction: Kidney transplant improves survival even in highly‑sensitized (HS) patients. To overcome their disadvantage in accessing transplantation, those with high Complement Dependent Cytotoxic PRA (CDC‑PRA) receive additional points during allocation. Whether this strategy reaches all HS patients and how long they wait for a transplant is largely undetermined. Methods: Patients on our unit’s active wait‑list for kidney transplantation in the year 2014 were analyzed. CDC‑PRA and calculated PRA (cPRA) were recorded. To obtain cPRA, antibodies in the last serum available specific for HLA‑A, ‑B or –DR with an intensity > 1000 MFI were considered. Results: The cPRA values in the population (N=551) were 0% (N=312), 1‑79% (N=118) and ≥ 80% (22%; N=121). Among these groups, the proportion of women (29.5, 55.9 and 61.2%, P 50%. Moreover, only 30% of HS by cPRA patients received the extra points designed to improve their transplantability. We consider that both CDC‑PRA and cPRA should be taken into account when defining HS status. info:eu-repo/semantics/publishedVersion
- Published
- 2016
196. Demographic and Health Changes in Portugal (1900-2013)
- Author
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Maria João Moreira and Filipa de Castro Henriques
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Health (social science) ,media_common.quotation_subject ,Population ,Demographic transition ,Public policy ,Modernization theory ,History and Philosophy of Science ,Political science ,Development economics ,Mortality ,education ,Ageing Year ,media_common ,education.field_of_study ,Health Policy ,lcsh:Public aspects of medicine ,Public Health, Environmental and Occupational Health ,Epidemological Transition ,lcsh:RA1-1270 ,language.human_language ,Epidemiological transition ,Ageing ,Demographic change ,language ,Demographic economics ,Demographic transitions ,Portuguese ,Welfare ,Epidemological transition - Abstract
s in other parts of Europe, Portugal experienced great advances during the twentieth century. It started with more than 100 years of monarchy, then a Republic (1910), and a dictatorial regime that lasted more than forty years (until 1974). The dictatorship ended by a peaceful “Revolution of the Carnations”1, the most decisive event at the end of the century. Alongside these political events, other factors contributed to (re)configure Portuguese society, harmonizing its modernization process with that of other European countries. In fact, improvements in population’s welfare sometimes took place unnoticed while occurring, only intelligible in the long term. It reflected the interdependence between demography, economy, wellbeing and public policy, in particular those implemented in healthcare areas. At the beginning of the twenty first century, long and stable life cycle emerged, replacing the previous short and instable life cycle. This new life cycle is accompanied by a stagnation in natural growth, more recently in Portugal. Since 2009, a new trend in Portuguese demography break-out, it has been continuously negative. The continuous drop in fertility, the decrease of mortality levels, not only of infant mortality but also in older age groups, contributed to an ageing society. Ageing has, in fact, become a dominant feature not only in Portugal but worldwide with consequences on support services for the elderly, adaptation of healthcare to new population groups and reformation of the public pension system. Our aim with this paper is to give an overview of the Portuguese health and demographic change through the twentieth century up until today, with special focus on the 1970’s until 2013, identifying the characteristics and specificities of the demographic and epidemiological transition model as well as the phases of the ageing process in Portugal in order to understand the different impacts on the health system. We base this article on own research; literature in different fields e.g. history
- Published
- 2016
197. TetraScript: A Responsive Pavilion, from Generative Design to Automation
- Author
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Gonçalo Castro Henriques
- Subjects
Engineering drawing ,Engineering ,business.industry ,Process (engineering) ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Pavilion ,Context (language use) ,Building and Construction ,Skylight ,Computer Graphics and Computer-Aided Design ,Automation ,Computer Science Applications ,Systems engineering ,Architecture ,Generative Design ,business ,Engineering design process - Abstract
This research is part of a broader investigation into the use of digital technologies in the Architecture, Engineering and Construction (AEC) sector. The intention is to improve the ability of buildings to respond to context by proposing a skylight system that can adjust to external environmental conditions and internal functional demands. We call this responsive ability customisation. The proposed skylight system can adapt to different geometries, uses, locations, times of day and other contextual conditions. Customisation can be achieved by static and dynamic processes. Static customisation is achieved during the design process by selecting the form and size of the building, as well as the number, arrangement and size of the skylights, among other features. Dynamic customisation is accomplished after construction by changing the skylight aperture in real-time to control interior conditions. This paper focuses on the static process to find an adequate skylight configuration for a case-study pavilion.
- Published
- 2012
198. Primeiro transplante renal ABO-incompatível realizado em Portugal
- Author
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Barreto, P., Vieira, P., Dias, L., Almeida, M., Pedroso, S., Martins, L., Castro-Henriques, A., Bini, M., and Cabrita, A.
- Subjects
ABO-incompatibility ,ABO -incompatibility ,kidney transplantation ,living donor ,Dador vivo ,incompatibilidade ABO ,transplantação renal - Abstract
Kidney transplantation is the optimal treatment of end -stage renal disease (ESRD) improving survival and quality of life for most recipients. In our country, potential living donors have been refused due to the ABO incompatibility barrier. However, ABO -incompatible living donor kidney transplant is presently common practice in several countries with good outcomes. The authors describe a case of a 49 -year -old female patient, with chronic kidney disease due to autosomal dominant polycystic kidney disease, who had started haemodialysis 10 months before and with blood group O. The living donor was a 53-year-old sister with blood group B. The desensitization protocol was based on rituximab and plasmapheresis. The induction protocol used was basiliximab, tacrolimus, mofetil mycophenolate and metilprednisolone. Five days post -transplant she presented a normal graft function that remained during the eight months follow -up. This case reveals the first ABO incompatible living donor kidney transplant performed in Portugal with excellent outcome O transplante renal é a modalidade de tratamento da doença renal crónica estadio 5 associada a melhores sobrevivência e qualidade de vida. No nosso país muitos potenciais dadores vivos têm sido recusados devido à incompatibilidade ABO. Contudo, o transplante renal de dador vivo ABO incompatível é hoje prática comum em diversos países com resultados positivos. Os autores descrevem o caso de doente do sexo feminino, de 49 anos, com doença renal crónica secundária a doença renal poliquística autossómica dominante, que havia iniciado hemodiálise 10 meses antes e com grupo sanguíneo O. O dador vivo foi uma irmã de 53 anos, grupo sanguíneo B. O protocolo de dessensibilização baseou-se em rituximab e plasmaferese. O protocolo de indução foi com basiliximab, tacrolimus, micofenolato de mofetil e metilprednisolona. Evoluiu com função normal do enxerto 5 dias pós -transplante que se manteve durante o follow -up de 8 meses. Este caso clinico ilustra o primeiro transplante renal de dador vivo ABO incompatível efectuado em Portugal com excelente resultado
- Published
- 2015
199. Sistemas responsivos: relevância, estado da arte e desenvolvimentos
- Author
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Gonçalo Castro Henriques
- Subjects
Computer science - Published
- 2015
200. Abrigos Sensíveis, do método ao conceito, superando a instrumentalização
- Author
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Gonçalo Castro Henriques and Andrés Martín Passaro
- Subjects
Computer science - Published
- 2015
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